CN111278835A - 治疗性金属络合物和配体及其制造和使用方法 - Google Patents

治疗性金属络合物和配体及其制造和使用方法 Download PDF

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Publication number
CN111278835A
CN111278835A CN201880065301.9A CN201880065301A CN111278835A CN 111278835 A CN111278835 A CN 111278835A CN 201880065301 A CN201880065301 A CN 201880065301A CN 111278835 A CN111278835 A CN 111278835A
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CN
China
Prior art keywords
aliphatic
compound
heteroaliphatic
aryl
heteroaryl
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Pending
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CN201880065301.9A
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English (en)
Chinese (zh)
Inventor
C·比尤德里
J·赫斯特
J·贝克曼
J·西罗伊斯
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Oregon State University
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Oregon State University
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Publication date
Application filed by Oregon State University filed Critical Oregon State University
Publication of CN111278835A publication Critical patent/CN111278835A/zh
Pending legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F1/00—Compounds containing elements of Groups 1 or 11 of the Periodic Table
    • C07F1/005—Compounds containing elements of Groups 1 or 11 of the Periodic Table without C-Metal linkages
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/155—Amidines (), e.g. guanidine (H2N—C(=NH)—NH2), isourea (N=C(OH)—NH2), isothiourea (—N=C(SH)—NH2)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/415—1,2-Diazoles
    • A61K31/4152—1,2-Diazoles having oxo groups directly attached to the heterocyclic ring, e.g. antipyrine, phenylbutazone, sulfinpyrazone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/425—Thiazoles
    • A61K31/428—Thiazoles condensed with carbocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A61K31/4545—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring hetero atom, e.g. pipamperone, anabasine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K33/00—Medicinal preparations containing inorganic active ingredients
    • A61K33/24—Heavy metals; Compounds thereof
    • A61K33/34—Copper; Compounds thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F1/00—Compounds containing elements of Groups 1 or 11 of the Periodic Table
    • C07F1/08—Copper compounds

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Organic Chemistry (AREA)
  • Inorganic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicinal Preparation (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
CN201880065301.9A 2017-09-01 2018-08-31 治疗性金属络合物和配体及其制造和使用方法 Pending CN111278835A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201762553714P 2017-09-01 2017-09-01
US62/553,714 2017-09-01
PCT/US2018/049163 WO2019046761A1 (en) 2017-09-01 2018-08-31 THERAPEUTIC METAL COMPLEXES AND LIGANDS, METHODS OF MAKING AND USING SAME

Publications (1)

Publication Number Publication Date
CN111278835A true CN111278835A (zh) 2020-06-12

Family

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Family Applications (1)

Application Number Title Priority Date Filing Date
CN201880065301.9A Pending CN111278835A (zh) 2017-09-01 2018-08-31 治疗性金属络合物和配体及其制造和使用方法

Country Status (8)

Country Link
US (2) US11596651B2 (https=)
EP (1) EP3676271A1 (https=)
JP (3) JP2020532538A (https=)
CN (1) CN111278835A (https=)
AU (1) AU2018325283B2 (https=)
CA (1) CA3074258A1 (https=)
IL (1) IL272895B2 (https=)
WO (1) WO2019046761A1 (https=)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL272895B2 (en) * 2017-09-01 2025-06-01 Univ Oregon State Therapeutic metal complexes and ligands and methods of making and using same
EP4003361A1 (en) * 2019-07-25 2022-06-01 ALS Therapy Development Institute Cuptsm for the treatment of neurodegenerative disorders
US12012422B2 (en) * 2020-08-26 2024-06-18 Als Therapy Development Institute Copper complexes for treatment of neurodegenerative disorders

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2008061306A1 (en) * 2006-11-20 2008-05-29 The University Of Melbourne Metal delivery agents and therapeutic uses of the same

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NL7403524A (en) 1959-09-15 1974-05-27 Pharmaceutical compsn. - contg. alpha-dithiosemicarbazone active against trichomonas vaginalis
US4107210A (en) 1976-09-07 1978-08-15 The Dow Chemical Company Synthesis of alpha-diketones
CA2166676C (en) * 1995-01-09 2007-05-01 Yasuhisa Fujibayashi Diagnostic agent for hypoxia or mitochondrial dysfunction comprising radioactive copper complex of dithiosemicarbazone derivative or diamine diol schiff base derivative
GB0617299D0 (en) * 2006-09-01 2006-10-11 Isis Innovation Compounds for imaging and therapy
JP5711142B2 (ja) * 2008-12-12 2015-04-30 ザ ユニバーシティ オブ メルボルン 非対称性ビス（チオセミカルバゾン）の調製方法
AU2014346476B2 (en) * 2013-11-11 2019-01-24 Collaborative Medicinal Development, Llc Metal complexes and methods of treatment
WO2017070752A1 (en) * 2015-10-29 2017-05-04 The University Of Queensland Imaging agents
WO2017214546A1 (en) * 2016-06-10 2017-12-14 University Of Louisville Research Foundation, Inc. Compounds, related compositions, catalysts, electrochemical cells, fuel cells, their preparation and their uses
WO2018204564A1 (en) * 2017-05-04 2018-11-08 University Of Louisville Research Foundation, Inc. Thiosemicarbazone derivatives as anti-cancer agents
IL272895B2 (en) * 2017-09-01 2025-06-01 Univ Oregon State Therapeutic metal complexes and ligands and methods of making and using same

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2008061306A1 (en) * 2006-11-20 2008-05-29 The University Of Melbourne Metal delivery agents and therapeutic uses of the same

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
EUGENE A. COATS等: ""Comparative Analysis of the Cytotoxicity of Substituted [Phenylglyoxal bis(4-methyl-3-thiosemicarbazone)]copper(II) Chelates. 2.Parabolic Correlations and Their Implications for Selective Toxicity"", 《JOURNAL OF MEDICINAL CHEMISTRY》 *
IRIS H. HALL等: ""The Cytotoxicity of Symmetrical and Unsymmetrical Bis(thiosemicarbazones) and Their Metal Complexes in Murine and Human Tumor Cells"", 《ARCH. PHARM. PHARM. MED. CHEM.》 *
JASON L. J. DEARLING等: ""Redox-active metal complexes for imaging hypoxic tissues: structure–activity relationships in copper(II) bis(thiosemicarbazone) complexes"", 《CHEM. COMMUN.》 *
LIAM ALSOP等: ""Investigations into some aryl substituted bis(thiosemicarbazones) and their copper complexes"", 《INORGANICA CHIMICA ACTA》 *

Also Published As

Publication number Publication date
IL272895A (en) 2020-04-30
WO2019046761A1 (en) 2019-03-07
AU2018325283A1 (en) 2020-03-12
JP2026041735A (ja) 2026-03-10
IL272895B2 (en) 2025-06-01
US20200188430A1 (en) 2020-06-18
EP3676271A1 (en) 2020-07-08
US12403159B2 (en) 2025-09-02
IL272895B1 (en) 2025-02-01
US20230172977A1 (en) 2023-06-08
US11596651B2 (en) 2023-03-07
JP2024001064A (ja) 2024-01-09
JP2020532538A (ja) 2020-11-12
AU2018325283B2 (en) 2023-11-16
CA3074258A1 (en) 2019-03-07

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