CN111267394A - Preparation process of indapamide sustained-release tablet - Google Patents
Preparation process of indapamide sustained-release tablet Download PDFInfo
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- CN111267394A CN111267394A CN202010123017.1A CN202010123017A CN111267394A CN 111267394 A CN111267394 A CN 111267394A CN 202010123017 A CN202010123017 A CN 202010123017A CN 111267394 A CN111267394 A CN 111267394A
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B30—PRESSES
- B30B—PRESSES IN GENERAL
- B30B11/00—Presses specially adapted for forming shaped articles from material in particulate or plastic state, e.g. briquetting presses, tabletting presses
- B30B11/02—Presses specially adapted for forming shaped articles from material in particulate or plastic state, e.g. briquetting presses, tabletting presses using a ram exerting pressure on the material in a moulding space
- B30B11/04—Presses specially adapted for forming shaped articles from material in particulate or plastic state, e.g. briquetting presses, tabletting presses using a ram exerting pressure on the material in a moulding space co-operating with a fixed mould
- B30B11/06—Presses specially adapted for forming shaped articles from material in particulate or plastic state, e.g. briquetting presses, tabletting presses using a ram exerting pressure on the material in a moulding space co-operating with a fixed mould each charge of the material being compressed against the previously formed body
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
- A61J3/00—Devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms
- A61J3/10—Devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms into the form of compressed tablets
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
- B01F33/00—Other mixers; Mixing plants; Combinations of mixers
- B01F33/40—Mixers using gas or liquid agitation, e.g. with air supply tubes
- B01F33/401—Methods
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B30—PRESSES
- B30B—PRESSES IN GENERAL
- B30B15/00—Details of, or accessories for, presses; Auxiliary measures in connection with pressing
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B30—PRESSES
- B30B—PRESSES IN GENERAL
- B30B15/00—Details of, or accessories for, presses; Auxiliary measures in connection with pressing
- B30B15/02—Dies; Inserts therefor; Mounting thereof; Moulds
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B30—PRESSES
- B30B—PRESSES IN GENERAL
- B30B15/00—Details of, or accessories for, presses; Auxiliary measures in connection with pressing
- B30B15/30—Feeding material to presses
- B30B15/302—Feeding material in particulate or plastic state to moulding presses
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- F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
- F26—DRYING
- F26B—DRYING SOLID MATERIALS OR OBJECTS BY REMOVING LIQUID THEREFROM
- F26B21/00—Arrangements or duct systems, e.g. in combination with pallet boxes, for supplying and controlling air or gases for drying solid materials or objects
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Abstract
The invention relates to the technical field of chemical pharmacy, in particular to a preparation process of indapamide sustained-release tablets. The specific technical scheme is as follows: a process for preparing indapamide sustained release tablet comprises sequentially adding sustained release material, filler, lubricant and indapamide into a medicinal powder stirrer, stirring and mixing; blowing air into the powder blender from the bottom, and/or from the top of the powder blender during blending; adding the mixed medicinal powder into a tabletting device for tabletting; finally, the compressed tablets are coated. The invention ensures that the prepared indapamide sustained-release tablet has uniform and stable release degree, improves the bioavailability of the medicine, and has less medicine loss and uniform medicine quality in the tabletting process by using special processes and equipment.
Description
Technical Field
The invention relates to the technical field of chemical pharmacy, in particular to a preparation process of indapamide sustained-release tablets.
Background
Indapamide is a non-thiazide indole derivative with dual effects of reducing blood pressure and promoting urination, and the small-dose blood pressure reducing effect is obvious. Oral administration is rapidly absorbed, binds to plasma proteins, selectively concentrates in vascular smooth muscle, inhibits the inward calcium flux of cells, reduces vasoconstriction, and the reactivity of blood vessels to pressure-boosting substances, thereby causing a decrease in vascular resistance, resulting in hypotensive activity. Indapamide has been widely used in the treatment of hypertension.
Currently used slow-release tablets of indapamide are generally slow-release preparations containing a small dose of 1.5mg of indapamide. 1.5mg of the slow-release indapamide greatly improves the effect/safety ratio of the antihypertensive effect, and meets the medication recommended by international professional guidelines for treatment using a small amount of antihypertensive drug and diuretic as first-line antihypertensive drug.
The prior patent application No. 201210090098.5 discloses a preparation method of a slow-release tablet containing indapamide, which is prepared by wetting HPMC through spraying, granulating and tabletting with other raw and auxiliary materials. The preparation method disclosed by the patent firstly has a complex process and is not beneficial to industrial mass production, and secondly, the HPMC is granulated and then mixed with the indapamide for tabletting, and as the skeleton material does not wrap the medicine, the slow-release effect is difficult to achieve.
The invention patent with the patent application number of 200810240504.5 discloses an indapamide sustained-release tablet and a preparation method thereof, wherein the range of selected framework materials is wide, the sustained-release effect is difficult to achieve in the actual preparation process, and the normal release of the drug in vivo cannot be ensured due to the sudden release or delayed release phenomenon of the drug release.
And when preparing indapamide sustained-release tablet, often adopt the tablet press to make a slice, current patent application number 201822256907.0 discloses a medicine tablet press, and it is including setting up sheeting mechanism and the defeated material mechanism on conveying mechanism, and defeated material mechanism comes the speed of control unloading through its control valve, and the sheeting mechanism realizes the preforming operation to powdered medicine through the cooperation between its briquetting and the model piece, but, this tablet press has following problem: in the process of controlling blanking by the material conveying mechanism, because the particle size of the powdery medicine is very small, part of the medicine generates dust in the falling process; and briquetting on the preforming mechanism is at the in-process that pushes down, because the impact force that the briquetting pushed down, also can make partly powder spout from the gap between briquetting and the model piece inner wall, not only can produce the problem of dust, still leads to the waste of medicine for the weight of the tablet after the tablet is accomplished is less than the weight of defeated material mechanism unloading at every turn. In addition, after the material conveying mechanism is fed, the thicknesses of the powdered medicines in the model block are inconsistent, and the thickness of the tablets pressed in the way is uneven, so that the quality of tabletting is reduced.
Disclosure of Invention
Aiming at the defects of the prior art, the invention provides a preparation process of an indapamide sustained-release tablet, and the special process and equipment thereof ensure that the prepared indapamide sustained-release tablet has uniform and stable release degree, improve the bioavailability of the medicine, and have less medicine loss and uniform medicine quality in the tabletting process.
In order to achieve the purpose, the invention is realized by the following technical scheme:
the invention discloses a preparation process of indapamide sustained-release tablets, which comprises the following steps:
(1) sequentially adding the slow-release material, the filler, the lubricant and the indapamide into a medicinal powder stirrer for stirring and mixing;
(2) blowing air into the powder blender from the bottom, and/or from the top of the powder blender during blending;
(3) adding the mixed medicinal powder into a tabletting device for tabletting;
(4) the compressed tablets are coated.
Preferably, the slow release material is one or more of hydroxypropyl methyl cellulose, hydroxypropyl cellulose, ethyl cellulose and methyl cellulose; the filler is one or more of lactose, microcrystalline cellulose and starch; the lubricant is one or more of magnesium stearate, talcum powder and silicon dioxide.
Preferably, the rotating speed of the powder stirrer is 40-120 r/min; and (2) when blowing air into the powder stirrer, drying and dedusting the air entering the powder stirrer at the air speed of 0.5-2 m/s.
Preferably, the tabletting device comprises a conveying mechanism, and a blanking mechanism and a tabletting mechanism which are arranged above the conveying mechanism; the conveying mechanism comprises a conveying belt and a mold groove formed in the conveying belt, the tabletting mechanism comprises a fixed plate and an air cylinder arranged at the bottom of the fixed plate, a transmission plate is fixed at the output end of the air cylinder, a pressing rod is fixed at the bottom of the transmission plate, and a pressing assembly is fixed at the other end of the pressing rod;
the pressing assembly comprises a pressing head and a plurality of sector grooves which are transversely arranged in the circumferential direction of the pressing head and perpendicular to the axis of the pressing head, sector blocks matched with the sector grooves are arranged in the sector grooves, a first spring is fixed on the arc-shaped side wall of each sector groove, and the other end of the first spring is fixed on the small arc-shaped face of each sector block.
Preferably, on the lateral wall of depression bar, be located the top swing joint of suppression subassembly has seal assembly, seal assembly includes the hollow round platform of bottom open-ended, the top of round platform is equipped with the confession the through-hole that the depression bar passed, the top of round platform, center on the circumference of depression bar is provided with flexible cover, in the flexible cover the top of round platform is fixed with a plurality of second spring, the other end of second spring is fixed top in the flexible cover.
Preferably, an air exhaust mechanism is fixed at the top of the circular truncated cone and comprises a telescopic air bag, a plurality of powder one-way valves are arranged at the top of the telescopic air bag, a plurality of air exhaust pipes are fixedly arranged at the bottom of the telescopic air bag, one end of each air exhaust pipe extends into the telescopic air bag, the other end of each air exhaust pipe penetrates through the telescopic cover and extends into the circular truncated cone, a plurality of fixing rods are uniformly fixed at the inner top of the telescopic air bag, and the other ends of the fixing rods are fixed at the top of the circular truncated cone; the side wall of the circular truncated cone is also provided with a plurality of powder one-way valves.
Preferably, the side wall of the pressure lever is provided with a plurality of first sliding grooves along the length direction of the pressure lever, and the inner wall of the through hole is provided with a plurality of balls; the ball is matched with the first sliding groove, so that the circular truncated cone moves up and down on the pressure rod through the matching of the first sliding groove and the ball; the first chute is completely covered by the telescopic cover.
Preferably, the bottom of the mold groove is provided with a jacking mechanism, the jacking mechanism comprises a mandril, one end of the mandril extends out of the bottom of the mold groove and out of the bottom of the conveying belt, the other end of the mandril extends into the mold groove, the end part of the mandril is fixed with a top head, the bottom of the mold groove is provided with a groove matched with the top head, and the top surface of the top head is flush with the bottom surface of the mold groove; the bottom in mould type groove, with be provided with a plurality of bar groove on the position of the bottom surface laminating of top, the bar groove centers on the ejector pin evenly sets up, bar groove bottom is fixed with the third spring, the other end of third spring is fixed the bottom surface of top.
Preferably, the blanking mechanism comprises a storage box, a blanking pipe is fixed at the bottom of the storage box, and a filler cover is arranged at the other end of the blanking pipe; a separator is arranged in the blanking pipe, so that two symmetrical cylindrical cavities with the same diameter are formed in the blanking pipe, and powder flow meters are respectively arranged in the two cylindrical cavities; and a material distributing assembly is fixed at the bottom of the separator and at the communication position of the blanking pipe and the filling cover.
Preferably, the material distribution assembly comprises a triangular prism with an equilateral triangle bottom surface, and the height of the triangular prism is smaller than the diameter of the blanking pipe, so that the triangular prism is just positioned in the pipe orifice of the blanking pipe; the side edges of the triangular prism are fixed at the bottom of the separator, symmetrical barrier strips are arranged on the side surfaces of the triangular prism, a connecting column is fixed on each barrier strip, and the other end of each connecting column is fixed at the inner top of the packing cover; two side faces of the triangular prism are respectively positioned above the two model grooves.
The invention has the following beneficial effects:
1. according to the invention, in the process of mixing the raw materials for preparing the indapamide sustained-release tablet, the raw materials are fully mixed in a blowing and stirring manner, so that the uniformity of the mixed powder is good, and the prepared tablet has uniform quality and less loss by using the tabletting device disclosed by the invention. Moreover, the indapamide sustained release tablet prepared by the invention has uniform and stable release degree, and improves the bioavailability of the drug.
2. According to the invention, the round table is arranged above the pressing head, the telescopic cover is arranged at the top of the round table and surrounds the ejector rod for a circle, one end of the telescopic cover is fixed on the circumferential side wall of the ejector rod, the plurality of second springs are vertically fixed in the telescopic cover, the round table moves upwards under extrusion to extrude the telescopic cover and the second springs, and in the extrusion process, the telescopic air bag fixed at the top of the telescopic cover is jacked up through the fixing rod, and since no air exists in the telescopic air bag, in the process of opening the telescopic air bag, the medicine powder sprayed out between the round table and the pressing head is sucked into the telescopic air bag through the air suction pipe fixed at the bottom of the telescopic air bag and extending into the cavity of the round table through the telescopic cover, so that the medicine powder dust is prevented from being raised due to the downward impact force of the pressing head in the pressing. Moreover, the tabletting device disclosed by the invention can ensure that the loss of the medicinal powder in the tabletting process is low to the maximum extent, and the quality of tablets is uniform, thereby ensuring that the loss of effective components of each tablet is low.
Drawings
FIG. 1 is a schematic structural view of the present invention;
FIG. 2 is a cross-sectional view of FIG. 1;
FIG. 3 is an enlarged view of a portion A of FIG. 2;
FIG. 4 is an enlarged view of portion B of FIG. 3;
FIG. 5 is an enlarged view of a portion C of FIG. 2;
FIG. 6 is an enlarged view of portion D of FIG. 5;
FIG. 7 is an enlarged view of E in FIG. 2;
FIG. 8 is a view taken along line A-A of FIG. 2;
FIG. 9 is a view taken along line B-B of FIG. 2;
FIG. 10 is a view showing the ram pressed into the mold groove;
FIG. 11 is a schematic structural view of the telescopic hood with an air suction mechanism;
FIG. 12 is an enlarged view of portion F of FIG. 11;
FIG. 13 is an enlarged view of portion G of FIG. 12;
FIG. 14 is an enlarged view of portion H of FIG. 13;
FIG. 15 is a view taken along line C-C of FIG. 11;
FIG. 16 is a state view of the suction mechanism with the ram pressed into the mold groove;
FIG. 17 is an enlarged view of portion I of FIG. 16;
in the figure: the device comprises a conveying belt 1, a model groove 2, a fixing plate 3, an air cylinder 4, a transmission plate 5, a pressure rod 6, a pressure head 7, a sector groove 8, a sector block 9, a first spring 10, a circular table 11, a telescopic cover 12, a second spring 13, a telescopic air bag 14, a powder one-way valve 15, an air suction pipe 16, a fixing rod 17, a first chute 18, balls 19, a push rod 20, a push head 21, a groove 22, a strip-shaped groove 23, a third spring 24, a storage box 25, a blanking pipe 26, a packing cover 27, a separator 28, a cylindrical cavity 29, a triangular prism 30, a barrier 31, a connecting column 32, a support 33, a roller 34, a barrier 35, an inner lining 36, a second chute 37, a sliding block 38, an upright column 39, a cover plate 40, a material collecting box 41, a.
Detailed Description
The technical solutions in the embodiments of the present invention will be clearly and completely described below with reference to the drawings in the embodiments of the present invention, and it is obvious that the described embodiments are only a part of the embodiments of the present invention, and not all of the embodiments. All other embodiments, which can be derived by a person skilled in the art from the embodiments given herein without making any creative effort, shall fall within the protection scope of the present invention.
Unless otherwise indicated, the technical means used in the examples are conventional means well known to those skilled in the art.
The invention discloses a preparation process of indapamide sustained-release tablets, which comprises the following steps:
(1) sequentially adding the slow-release material, the filler, the lubricant and the indapamide into a medicinal powder stirrer for stirring and mixing;
(2) blowing air into the powder blender from the bottom, and/or from the top of the powder blender during blending; it should be noted that: the powder stirrer is the existing equipment, and blows air into the stirrer while stirring the powder, so that the powder in the stirrer forms dust, and is better mixed in the stirring process, so that the powder is more uniformly mixed; and in the process of blowing air, the powder in the stirrer can be blown up from the top or the bottom of the powder stirrer, or the powder can be blown simultaneously from the top and the bottom of the stirrer, in order to avoid blowing the powder by the top and the bottom blowers, the air is blown by the right side at the top of the stirrer, and the air is blown by the left side at the bottom, so that the air blowers at the top and the bottom are staggered, and the aim of uniformly mixing the powder is finally fulfilled.
(3) Adding the mixed medicinal powder into a tabletting device for tabletting;
(4) the compressed tablets are coated.
Wherein the slow release material is one or more of hydroxypropyl methylcellulose, hydroxypropyl cellulose, ethyl cellulose and methylcellulose; the filler is one or more of lactose, microcrystalline cellulose and starch; the lubricant is one or more of magnesium stearate, talcum powder and silicon dioxide. The proportion of the slow-release material, the filler, the lubricant and the active ingredient of the indapamide is conventionally selected according to actual conditions, and the indapamide is finally prepared into a 1.5mg slow-release tablet, and the dosage of the active ingredient of the indapamide can be adjusted according to the dosage of a prescription. For example, the slow release material comprises, by weight, 10-60% of the slow release material, 20-80% of the filler, 0.2-3% of the lubricant, and 0.1-20% of the indapamide.
The rotation speed of the powder stirrer is 40-120 r/min, preferably 80r/min, and the stirring time is 30-120 min, preferably 40 min; in the step (2), when the air is blown into the powder stirring machine, the air entering the powder stirring machine is dried and dedusted, and the air speed is 0.5-2 m/s, preferably 1m/s, so that the raw materials are mixed more uniformly, and the blowing time is the same as the stirring time.
Referring to fig. 1-17, the disclosed tablet pressing device includes a conveying mechanism, and a blanking mechanism and a tablet pressing mechanism arranged above the conveying mechanism in parallel; the conveying mechanism comprises symmetrically arranged brackets 33 and rollers 34 symmetrically arranged on the brackets 33, the conveying belt 1 is sleeved on the two rollers 34, and one of the rollers 34 is driven by a motor to rotate so as to enable the conveying belt 1 to run. Flanges 35 are provided on both sides of the conveyor belt 1. A plurality of model grooves 2 are equidistantly arranged on the conveying belt 1 along the length direction of the conveying belt 1, and the model grooves 2 are sequentially arranged along the length direction of the conveying belt 1 and are positioned on the same straight line. It should be noted that: in order to better fix the blanking mechanism and the tablet pressing mechanism, two symmetrical cross rods 42 are respectively fixed at two ends of the support 33, the other ends of the two cross rods 42 are respectively fixed with two ends of the other support 33, and the fixed plate 3 and the storage box 25 are respectively fixed on the two cross rods 42 through fixed columns 43, so that the blanking mechanism and the tablet pressing mechanism are positioned right above the conveying belt 1. And a material collecting box 41 is provided on one side of the conveyor belt 1 on one side of the sheet pressing mechanism (referring to fig. 2, the material collecting box 41 is located on the right side of the sheet pressing mechanism). In particular, it should be understood that: the one end that two supports 33 lie in the homonymy is fixed through horizontal pole 42, and two horizontal poles 42 symmetry sets up and parallel with ground, and fixed column 43 can be a plurality of, increase the stability of unloading mechanism and preforming mechanism. The fixed columns 43 fixed on the blanking mechanism and the fixed columns 43 fixed on the tabletting mechanism are respectively fixed on the two symmetrical cross rods 42, so that the blanking mechanism and the tabletting mechanism stretch across the conveying belt 1, and the filling cover 27 and the pressure head are positioned at the center of the conveying belt 1, and the mould groove 2 can be correspondingly operated.
The bottom of the mold groove 2 is provided with a jacking mechanism, the jacking mechanism comprises an ejector rod 20, one end of the ejector rod 20 extends out of the bottom of the mold groove 2 and extends out of the bottom of the conveying belt 1, the other end of the ejector rod 20 extends into the mold groove 2, an ejector head 21 is fixed at the end part of the ejector rod, the bottom of the mold groove 2 is provided with a groove 22 matched with the ejector head 21, and when the ejector head 21 is positioned in the groove 22, the top surface of the ejector head 21 is flush with the bottom surface of the mold groove 2, so that the surface of a pressed tablet; the bottom of mould type groove 2, be provided with a plurality of bar groove 23 on the position of the bottom surface laminating with top 21, bar groove 23 evenly sets up around ejector pin 20, and bar groove 23 bottom is fixed with third spring 24, and the bottom surface at top 21 is fixed to third spring 24's the other end. It should be understood that: the ejector pin 20 is disposed at the center of the bottom of the pattern groove 2, and the bar groove 23 is disposed around the axis of the ejector pin 20. The bottom of conveyer belt 1 is stretched out to the one end of ejector pin 20, when conveyer belt 1 moved on gyro wheel 34, because conveyer belt 1 was the laminating with gyro wheel 34 to make gyro wheel 34 extrude the ejector pin 20 of stretching out conveyer belt 1, make top 21 on the ejector pin 20 separate with the bottom in model groove 2, finally make the tablet of being pressed in the model groove 2 and the inner wall separation in model groove 2, thereby avoid the difficult problem that drops from the model groove 2 of the tablet of being pressed.
Further, in order to prevent the pressed tablet from adhering to the top surface of the top 21 and to reduce the contact surface between the top 21 and the tablet or powder, the top 21 is formed in a stepped shape, the size of the top surface of the top 21 is smaller than that of the bottom of the die groove 2, the center of the small-diameter end of the top 21 is fixed to the top rod 20, and the third spring 24 is fixed to the bottom surface of the small-diameter end of the top 21. Since the groove 22 is adapted to the plug 21, the shape of the groove 22 is stepped, and the strip-shaped groove 23 is disposed at the bottom of the groove 22 and is communicated with the groove 22. It should be understood that: if the surface of the tablet is printed with information such as characters, patterns and the like, the corresponding patterns are arranged on the top 21 or the pressure head 7. Moreover, the quantity that the bar groove 23 set up is according to conventional setting, and the bar groove 23 evenly sets up around the axle center of ejector pin to make top 21 bottom surface atress even, make top 21 get back to the recess 22 again in owing to the reaction force of third spring 24 makes top 21, thereby avoid top 21 bottom atress inhomogeneous and lead to top 21 and recess 22 dislocation, make top 21 just can not fall into in the recess 22.
Furthermore, in order to reduce the friction between the ram 7 and the inner wall of the mold groove 2 and to avoid the sticking of the tablet to the inner wall of the mold groove 2 as much as possible, a liner 36 is provided in the mold groove 2 so as to be attached to both the inner wall and the bottom of the mold groove 2. The liner 36 is made of hard plastic and has a smooth surface. At this time, the strip-shaped groove 23 extends out of the inner liner 36 at the bottom of the mold groove 2, and the groove 22 is provided on the inner liner 36. The strip-shaped groove 23 is communicated with the groove 22, and the top 21 is arranged in the groove 22.
The blanking mechanism comprises a storage box 25, a blanking pipe 26 is fixed at the bottom of the storage box 25, and a filler cover 27 is arranged at the other end of the blanking pipe 26; the separator 28 is disposed in the feeding pipe 26, two symmetrical cylindrical cavities 29 with the same diameter are formed in the feeding pipe 26, the powder flow meters are disposed in the two cylindrical cavities 29, and further, in order to prevent the powder from accumulating on the top of the separator 28, the top of the separator 28 may be an inclined surface, specifically, an inclined surface inclined toward the axis of the cylindrical cavity 29. A material distributing assembly is fixed to the bottom of the divider 28 at the connection between the feed pipe 26 and the filling cap 27. The material distributing assembly comprises a triangular prism 30 with an equilateral triangle bottom surface, and the height of the triangular prism 30 is smaller than the diameter of the blanking pipe 26, so that the triangular prism 30 is just positioned in the pipe orifice of the blanking pipe 26; the side edge of the triangular prism 30 is fixed at the bottom of the separator 28, symmetrical barrier strips 31 are arranged on the side surface of the triangular prism 30, connecting columns 32 are fixed on the barrier strips 31, and the other ends of the connecting columns 32 are fixed at the inner top of the packing cover 27; two side surfaces of the triangular prism 30 are respectively positioned above the two mold grooves 2.
It should be understood that: the material distributing component is used for respectively filling the medicinal powder in the two cylindrical cavities 29 into two adjacent mold grooves 2, so that the mold grooves 2 are filled with the medicinal powder in a quantitative mode, and the weight of each tablet is uniform. In order to prevent the medicine powder from leaking from the triangular prism 30 to the conveyer belt 1, the height of the triangular prism 30 is the same as the pipe diameter of the blanking pipe 26, wherein the height of the triangular prism 30 refers to the length of the side quadrangle of the triangular prism 30; and the left and right sides of the two four-sided sides of the triangular prism 30 are respectively provided with a barrier strip 31, and the barrier strips 31 are fixed at the inner top of the packing cover 27 through connecting columns 32, so that the triangular prism 30 is more stable. Further, the common edges of the two quadrangles of the triangular prism 30 are fixed to the bottom of the divider 28 so that the two cylindrical cavities 29 communicate with the two quadrangular side surfaces of the triangular prism 30, respectively, and the powder passes through the cylindrical cavities 29 and the side surfaces of the triangular prism 30 to enter the adjacent model grooves 2, respectively. The bottoms of the two quadrangular side surfaces of the triangular prism 30 are positioned above the model groove 2, so that the medicine powder can enter the model groove 2 accurately. In addition, powder flow meters are fixed to the discharging pipes 26 for controlling the weight of the powder falling through the two cylindrical cavities 29, respectively, so that the weight of the powder finally entering the model groove 2 is constant. It should be noted that: the inclination degree of two sides of the triangular prism 30 and the distance between two adjacent mold grooves 2 are set according to actual conditions.
Further, in order to prevent the powder from generating dust during the falling of the powder from the inclined surface of the triangular prism 30, the bottom of the packing cap 27 is attached to the top surface of the conveyor belt 1. Furthermore, the packing cage 27 completely covers the adjacent two mold grooves 2. It should be understood that: the width of the filler cap 27 is greater than the diameter of the mold groove 2, and the length is set according to practical conditions, for example, greater than the distance between two adjacent mold grooves 2. In order to fill more than two mold grooves 2, a plurality of groups of blanking mechanisms can be arranged for blanking simultaneously.
The tabletting mechanism comprises a fixed plate 3 and an air cylinder 4 arranged at the bottom of the fixed plate 3, a transmission plate 5 is fixed at the output end of the air cylinder 4, a pressing rod 6 is fixed at the bottom of the transmission plate 5, and a pressing component is fixed at the other end of the pressing rod 6; the pressing assembly comprises a pressing head 7 and a plurality of fan-shaped grooves 8 which are transversely arranged on the periphery of the pressing head 7 and are vertical to the axis of the pressing head 7, fan-shaped blocks 9 matched with the fan-shaped grooves 8 are arranged in the fan-shaped grooves 8, first springs 10 are fixed on the arc-shaped side walls of the fan-shaped grooves 8, and the other ends of the first springs 10 are fixed on small arc-shaped surfaces of the fan-shaped blocks 9. The pressure head 7 is matched with the model groove 2, so that the pressure head 7 can just extend into the model groove 2.
It should be understood that: after the sector 9 is compressed towards the sector groove 8, the large arc-shaped surface of the sector 9 forms the outer side wall of the pressure head 7; the pressure head 7 is matched with the model groove 2, so that the pressure head 7 just extends into the model groove 2; the sector grooves 8 do not extend to the axial center of the ram 7. Further, in order to smoothly press the segment 9 into the segment groove 8, the opening of the mold groove 2 is formed in a bell mouth shape so that the segment 9 is gradually compressed into the segment groove 8 along the inclined surface of the side wall of the mold groove 2 during the downward movement of the ram 7.
The compressible fan-shaped block 9 is arranged on the pressure head 7, so that the powder is prevented from being sprayed out from a gap between the pressure head 7 and the inner wall of the model groove 2 by the impact force on the powder in the process that the pressure head 7 is pressed down, medicine dust is caused, and the mass of each tablet is different. The method specifically comprises the following steps: referring to fig. 10, in the process of pressing the ram 7, the sector 9 is compressed into the sector 8, and when the ram 7 is pressed down until the diameter of the model groove 2 is not changed any more (i.e. below the bell mouth on the model groove 2), i.e. after the sector 9 is completely compressed into the sector 8, the first spring 10 applies a reaction force to the sector 9 due to being compressed, so that the edge of the sector 9 is attached to the inner wall of the model groove 2 more tightly, and the powder can be prevented from being sprayed out from the gap between the ram 7 and the model groove 2 to the greatest extent. The number of the fan-shaped blocks 9 is set conventionally according to actual needs, the number of the fan-shaped blocks 9 is preferably 4, and the fan-shaped grooves 8 are uniformly arranged on the side wall of the pressure head 7, namely the 4 fan-shaped blocks 9 are respectively symmetrical pairwise.
In the invention, a plurality of pressing heads 7 can be arranged to press a plurality of tablets simultaneously, and only one pressing head can be arranged. The number of the pressing heads 7 is preferably 3, and the medicinal powder in 3 adjacent model grooves 2 is simultaneously pressed. Therefore, the rotating speed and the time of the motor for driving the conveying belt 1 to walk are determined according to the number of the pressing heads 7 and the distance between the adjacent mold grooves 2, so that the pressing operation can be continuously carried out, and the situation that the medicine powder in the same mold groove 2 is repeatedly pressed or leaks is avoided. When the pressure heads 7 are arranged to be 3, the pressure rods 6 are arranged at the bottom of the transmission plate 5 in an equidistant and uniform mode and are positioned on the same straight line, and the specific distance between the pressure rods 6 is the distance between the model grooves 2, so that the 3 pressure heads 7 can form an up-and-down symmetrical relation with the adjacent 3 model grooves 2, and the 3 pressure heads 7 can be simultaneously inserted into the adjacent 3 model grooves 2. At this moment, the two cylinders 4 arranged on the transmission plate 5 are preferably selected, the two cylinders are symmetrically arranged on the transmission plate 5 and correspond to the pressure rod 6, and then the fixing plate 3 for fixing the cylinder 4 is also the same, so that the stability of the whole tabletting mechanism in the operation process and the uniformity of stress of each tabletting can be ensured. The starting driving plate 5 can be a cylinder 4 or an electric push rod which is pressed downwards, and the conventional setting is carried out according to the actual situation.
Further, because there is the clearance between the segment 9, unable complete avoidance powder can not follow the blowout of gap between pressure head 7 and the model groove 2, can be on the lateral wall of depression bar 6, the top swing joint that is located the pressing assembly has a seal assembly, seal assembly includes bottom open-ended hollow round platform 11, the top of round platform 11 is equipped with the through-hole that supplies depression bar 6 to pass, the top of round platform 11, be provided with telescopic cover 12 around depression bar 6 on the circumference, in the telescopic cover 12, the top of round platform 11 is fixed with a plurality of second spring 13, the other end of second spring 13 is fixed at the top in telescopic cover 12.
It should be understood that: the circular table 11 can move up and down on the press rod 6. The diameter of the bottom of the circular truncated cone 11 is equal to the distance between the two symmetrical fan-shaped blocks 9 and is smaller than the diameter between the bell mouths on the die groove 2, so that the bottom of the circular truncated cone 11 is tightly attached to the side wall of the bell mouth on the die groove 2 after the circular truncated cone 11 runs downwards. Further, in order to reduce the friction force between the circular truncated cone 11 and the compression bar 6, a plurality of first sliding grooves 18 which are parallel to each other are formed in the side wall of the compression bar 6 along the length direction of the compression bar 6, and a plurality of balls 19 are arranged on the inner wall of a through hole in the top of the circular truncated cone 11; the ball 19 is matched with the first chute 18, so that the circular truncated cone 11 moves up and down on the pressure rod 6 through the matching of the first chute 18 and the ball 19; referring to fig. 3, the top side of the telescopic cover 12 is fixed to the side wall of the press rod 6 and completely covers the first slide groove 18.
Referring to fig. 10, during the depression of the ram 7, the movement of the sealing assembly is as follows: when the pressure head 7 is pressed down to enable the bottom of the circular truncated cone 11 to be in contact with the bell mouth of the die groove 2, the pressure head 7 is continuously pressed down at the moment, the circular truncated cone 11 is abutted against the die groove 2 and cannot move downwards any more, therefore, when the pressure head 7 continuously moves downwards, the ball 19 slides upwards in the first sliding groove 18, and meanwhile, the top of the circular truncated cone 11 extrudes the telescopic cover 12 and the second spring 13 until the pressure head 7 finishes tabletting work of medicinal powder. Then, the pressure head 7 moves upwards, and when the pressure head moves to the bell mouth of the die groove 2, the first spring 10 is not extruded any more, so that the reaction force of the first spring 10 after compression pushes the fan-shaped block 9 out of the fan-shaped groove 8; at this time, the circular truncated cone 11 is no longer abutted against the inner wall of the mold groove 2, and the reaction force of the compressed second spring 13 (the reaction force generated by the compressed telescopic cover 12 is used for assisting the circular truncated cone 11 to return) makes the circular truncated cone 11 move downward through the cooperation of the balls 19 and the first slide groove 18, and finally the return is completed.
Furthermore, in order to avoid the sprayed medicine from falling on the side walls of the conveying belt 1 and the circular truncated cone 11, an air exhaust mechanism can be fixed at the top of the circular truncated cone 11, the air exhaust mechanism comprises a telescopic air bag 14, a plurality of powder one-way valves 15 are arranged at the top of the telescopic air bag 14, a plurality of air exhaust pipes 16 are fixedly arranged at the bottom of the telescopic air bag 14, one end of each air exhaust pipe 16 extends into the telescopic air bag 14, the other end of each air exhaust pipe penetrates through the telescopic cover 12 and extends into the circular truncated cone 11, a plurality of fixing rods 17 are uniformly fixed at the inner top of the telescopic air bag 14, and the other ends of the; the side wall of the circular truncated cone 11 is also provided with a plurality of powder check valves 15.
It should be understood that: the bellows 14 is annular. The telescopic air bag 14 is fixed on the top of the circular truncated cone 11 and is arranged around the compression bar 6 in a circle. When not in use, the bellows 14 is in a compressed state, and no air is present inside. The air exhaust pipes 16 are a plurality of and fixed at the bottom of the telescopic air bag 14 and arranged around the axis of the pressure rod 6, the number of the air exhaust pipes 16 is set according to actual needs, one end of each air exhaust pipe 16 extends into the telescopic air bag 14, the other end of each air exhaust pipe passes through the top of the telescopic cover 12, passes through the inside of the telescopic cover 12, penetrates out of the top of the circular truncated cone 11 and enters the inside of the circular truncated cone 11.
It should be noted that: the air exhaust pipe 16 is fixed with the bottom of the telescopic air bag 14 and the top of the telescopic cover 12 fixed with the bottom of the telescopic air bag, the circular truncated cone 11 is not fixed with the air exhaust pipe 16, and the circular truncated cone 11 is in clearance fit with the air exhaust pipe 16, so that the circular truncated cone 11 can move up and down on the air exhaust pipe 16. And one end of a fixed rod 17 arranged in the telescopic air bag 14 is fixed on the top in the telescopic air bag 14, the other end of the fixed rod 17 penetrates through the bottom of the telescopic air bag 14 and the top of the telescopic cover 12 and is fixed on the top of the circular truncated cone 11 through the inside of the telescopic cover 12, and the fixed rod 17 and the bottom of the telescopic air bag 14 and the top of the telescopic cover 12 are in clearance fit, so that the bottom of the telescopic air bag 14 and the top of the telescopic cover 12 can move on the fixed rod 17. Moreover, the number of the fixing rods 17 is set according to actual conditions, and the fixing rods are uniformly fixed on the inner top of the telescopic air bag 14. The fixing rod 17 and the suction tube 16 are not required to be arranged at any positions and can be arranged conventionally.
It should also be noted that: the powder check valve 15 provided on the telescopic bag 14 enables the air in the telescopic bag 14 to be discharged, the medicine powder sucked into the telescopic bag 14 to be discharged, and the air which is not the outside air to enter the telescopic bag 14. The powder one-way valve 15 arranged on the side wall of the circular truncated cone 11 can enable outside air to enter the circular truncated cone 11, and air in the circular truncated cone 11 cannot be discharged. Therefore, the powder check valve 15 on the telescopic airbag 14 and the powder check valve 15 on the circular truncated cone 11 are arranged in different directions, and the purpose is also different.
Furthermore, in order to fix the telescopic airbag 14 on the telescopic cover 12 well, a slide block 38 is arranged on the side wall of the telescopic airbag 14 near the top thereof, a second slide groove 37 matched with the slide block 38 is arranged on the side wall of the press rod 6 corresponding to the slide block 38, the length of the second slide groove 37 is greater than that of the fixed rod 17, and the length of the telescopic airbag 14 after being completely expanded is less than that of the second slide groove 37.
Furthermore, in order to prevent the medicine powder sucked in the telescopic air bag 14 from being discharged to the side wall of the conveyer belt 1 or the pressure head 7 through the air exhaust tube 16 again in the process that the air in the telescopic air bag 14 is discharged through the powder one-way valve 15 when the telescopic air bag 14 is reset, two symmetrical upright posts 39 are fixed on the top end surface of the air exhaust tube 16 positioned in the telescopic air bag 14, a cover plate 40 is connected on the upright posts 39 in a sliding manner, the diameter of the cover plate 40 is larger than that of the air exhaust tube 16, so that the cover plate 40 completely covers the air exhaust tube 16, the cover plate 40 can move up and down on the upright posts 39, and in order to prevent the cover plate 40 from sliding out of the upright posts 39, two symmetrical limit strips (not shown in the figure) can be arranged on the. It should be understood that: during the process of air extraction (medicine powder and air) by the air extraction pipe 16, the cover plate 40 is jacked up by air flow, so that the medicine powder enters the telescopic air bag 14; when the air bag 14 is reset, the cover plate 40 falls down to cover the mouth of the air exhaust tube 16, so as to prevent the medicine powder in the air bag 14 from being discharged again. In addition, in order to avoid the extraction pipe 16 from separating from the top of the circular truncated cone 11, symmetrical limiting strips are arranged on the side wall of the extraction pipe 16 positioned in the circular truncated cone 11 and close to the pipe orifice of the extraction pipe. In addition, at least one outlet may be provided on the outer side wall of the bellows 14 near the bottom thereof for cleaning the bellows 14.
When the blanking mechanism is used, the operation process of the blanking mechanism is as follows: the powder in the storage box 25 enters the blanking pipe 26, the powder flowmeter is started according to the set weight, the powder enters the two cylindrical cavities 29 respectively, when the specified weight is reached, the powder flowmeter is closed, and the powder enters the model groove 2 through the inclined plane of the triangular prism 30. Then, the motor is started, the conveyer belt 1 runs, and the blanking mechanism is enabled to fill the empty mold groove 2. The distance of the conveyor belt 1 travel is set according to the distance between every two mould grooves 2, so that the packing cage 27 can just completely cover the next set of mould grooves 2 and accurate packing can be carried out.
When the model groove 2 filled with the medicinal powder runs below the tablet pressing mechanism, the motor stops starting, the air cylinder 4 is started again, the pressure head 7 is pressed downwards, the fan-shaped block 9 contacts the bell mouth of the model groove 2 to force the fan-shaped block 9 to compress towards the fan-shaped groove 8, when the fan-shaped block 9 is completely pressed into the fan-shaped groove 8, the bottom of the circular truncated cone 11 is abutted against the inner wall of the bell mouth of the model groove 2, and in the process that the pressure head 7 is pressed downwards continuously, the circular truncated cone 11 cannot be pressed downwards any more, so that the circular truncated cone 11 compresses the telescopic cover 12 and the second spring 13 through the matching between the first slide way 18 and the ball 19. Meanwhile, the fixing rod 17 pushes up the telescopic air bag 14, and because the telescopic air bag 14 is empty of air, the air suction pipe 16 sucks the medicine powder overflowing between the circular truncated cone 11 and the pressure head 7 into the telescopic air bag 14 together with air through the air suction pipe 16, and the air in the cavity between the circular truncated cone 11 and the pressure head 7 is supplemented through the powder one-way valve 15, so that the pressure of the circular truncated cone 11 and the outside is balanced. Finally, the pressing head 7 completes the tablet pressing work of the medicinal powder. Finally, the air cylinder 4 is started, the ram 7 is lifted, the sector 9 is ejected from the sector groove 8 by the first spring 10, the round platform 11 is moved downwards by the reaction force of the second spring 13, the fixing rod 17 presses the telescopic air bag 14 downwards, and the air in the telescopic air bag 14 is discharged through the powder one-way valve 15, and finally the telescopic air bag is reset. Then, the motor is started, the conveyer belt 1 runs, and the next group of die-shaped grooves 2 for pressing tablets run to the lower part of the tablet pressing mechanism.
In order to make the starting time of the cylinder 4 and the running time of the conveyer belt 1 well matched, a plurality of displacement sensors can be arranged outside the conveyer belt 1, the distance of each displacement sensor is the distance between the model grooves 2 which need to be pressed simultaneously, a receiver is arranged on the pressing mechanism and used for receiving the position information transmitted by the displacement sensors, the receiver transmits the received position information transmitted by the displacement sensors to the controller, and the controller controls the starting and stopping time of the motor and the cylinder 4 according to the position information.
It should be noted that: if tablets with cambered surfaces up and down are to be pressed, the bottom of the mold groove 2 is only required to be set to be a concave cambered surface, correspondingly, the top 21 is also set to be a cambered surface attached to the mold groove 2, and the pressure head 7 is set to be a concave cambered surface corresponding to the cambered surface at the bottom of the mold groove 2, so that the pressing of tablets with different shapes is completed (the part is not shown in the figure). At this time, the shape of the segment 9 and the segment groove 8 is also the same as that of the ram 7, and the segment 9 is made to be in an arc shape, so that the segment can be extended and contracted normally. And the shape of the top head 21 of the jacking mechanism is the same as that of the bottom of the die groove 2, and of course, the shape of the groove 22 is matched with that of the top head 21.
Using the manufacturing process and tableting apparatus of the present invention, 100 compressed tablets (not coated) were weighed, with a powder flow meter controlling the weight of the powder in each mold groove to be 2.00 g. Then, the theoretical weight of 100 compressed tablets was 200.00g, while the actual weight was 199.98g, with a small error, indicating that the loss per tablet was small using the tabletting device of the present invention.
The indapamide sustained-release tablets prepared by the invention are taken for release degree investigation, 3 tablets are measured in each group, the average value is taken, and 10 groups are tested in total. The test method is as follows:
taking the product, according to a dissolution determination method (XC third method which is an appendix of the second part of the 2010 edition of Chinese pharmacopoeia), taking 100ml of water as a solvent, rotating at 50 revolutions per minute, operating according to the method, respectively taking 1ml of the solution and filtering at 1 st, 4 th, 10 th, 16 th and 24 th hours, discarding an initial filtrate, taking a subsequent filtrate as a test solution, and determining according to a high performance liquid chromatography (VD which is an appendix of the second part of the 2010 edition of Chinese pharmacopoeia). The chromatographic condition is that octadecylsilane chemically bonded silica is used as a filler; methanol-water-glacial acetic acid (45: 55: 0.1) as a mobile phase; the detection wavelength was 240 nm. Injecting 10 μ l of the filtrate into a liquid chromatograph, and measuring the peak area; taking appropriate amount of indapamide reference substance, dissolving with ethanol, diluting with mobile phase to obtain solution containing 15 μ g of indapamide per 1ml, and measuring by the same method. The peak area was measured. The amount of released indapamide was calculated by the external standard method, and the test results are shown in Table 1, and the comparative example is a commercially available indapamide sustained release tablet without coating. The result shows that the release rate of the indapamide sustained-release tablet prepared by the equipment and the method is obviously improved, the release rate is uniform and stable, and the bioavailability is improved.
TABLE 1 Indapamide extended release tablet release rate results at different time periods
In the description of the present invention, it is to be understood that the terms "longitudinal", "lateral", "upper", "lower", "front", "rear", "left", "right", "vertical", "horizontal", "top", "bottom", "inner", "outer", and the like, indicate orientations or positional relationships based on those shown in the drawings, are merely for convenience of description of the present invention, and do not indicate or imply that the referenced devices or elements must have a particular orientation, be constructed and operated in a particular orientation, and thus, are not to be construed as limiting the present invention.
The above-described embodiments are merely illustrative of the preferred embodiments of the present invention, and do not limit the scope of the present invention, and various modifications and improvements of the technical solutions of the present invention can be made by those skilled in the art without departing from the spirit of the present invention, and the technical solutions of the present invention are within the scope of the present invention defined by the claims.
Claims (10)
1. A preparation process of indapamide sustained release tablets is characterized by comprising the following steps: the method comprises the following steps:
(1) sequentially adding the slow-release material, the filler, the lubricant and the indapamide into a medicinal powder stirrer for stirring and mixing;
(2) blowing air into the powder blender from the bottom, and/or from the top of the powder blender during blending;
(3) adding the mixed medicinal powder into a tabletting device for tabletting;
(4) the compressed tablets are coated.
2. The process for preparing an indapamide sustained-release tablet according to claim 1, which comprises the following steps: the slow release material is one or more of hydroxypropyl methyl cellulose, hydroxypropyl cellulose, ethyl cellulose and methyl cellulose; the filler is one or more of lactose, microcrystalline cellulose and starch; the lubricant is one or more of magnesium stearate, talcum powder and silicon dioxide.
3. The process for preparing an indapamide sustained-release tablet according to claim 1, which comprises the following steps: the rotation speed of the powder stirrer is 40-120 r/min, and the stirring time is 30-120 min; and (2) when blowing air into the powder stirrer, drying and dedusting the air entering the powder stirrer at the air speed of 0.5-2 m/s.
4. The process for preparing an indapamide sustained-release tablet according to claim 1, which comprises the following steps: the tabletting device comprises a conveying mechanism, and a blanking mechanism and a tabletting mechanism which are arranged above the conveying mechanism; the conveying mechanism comprises a conveying belt (1) and a mold groove (2) formed in the conveying belt (1), the tabletting mechanism comprises a fixing plate (3) and an air cylinder (4) arranged at the bottom of the fixing plate (3), a transmission plate (5) is fixed at the output end of the air cylinder (4), a pressing rod (6) is fixed at the bottom of the transmission plate (5), and a pressing assembly is fixed at the other end of the pressing rod (6);
the pressing component comprises a pressing head (7) and a plurality of fan-shaped grooves (8) which are transversely formed in the circumferential direction of the pressing head (7) and perpendicular to the axis of the pressing head (7), fan-shaped blocks (9) matched with the fan-shaped grooves (8) are arranged in the fan-shaped grooves (8), first springs (10) are fixed on arc-shaped side walls of the fan-shaped grooves (8), and the other ends of the first springs (10) are fixed on small arc-shaped surfaces of the fan-shaped blocks (9).
5. The process for preparing an indapamide sustained-release tablet according to claim 4, wherein: on the lateral wall of depression bar (6), be located the top swing joint of suppression subassembly has seal assembly, seal assembly includes bottom open-ended hollow round platform (11), the top of round platform (11) is equipped with the confession the through-hole that depression bar (6) passed, the top of round platform (11), center on be provided with flexible cover (12) in the circumference of depression bar (6), flexible cover (12) in the top of round platform (11) is fixed with a plurality of second spring (13), the other end of second spring (13) is fixed top in flexible cover (12).
6. The process for preparing an indapamide sustained-release tablet according to claim 5, wherein: the top of the circular table (11) is fixedly provided with an air extracting mechanism, the air extracting mechanism comprises a telescopic air bag (14), the top of the telescopic air bag (14) is provided with a plurality of powder one-way valves (15), the bottom of the telescopic air bag (14) is fixedly provided with a plurality of air extracting pipes (16), one end of each air extracting pipe (16) extends into the telescopic air bag (14), the other end of each air extracting pipe penetrates through the telescopic cover (12) and extends into the circular table (11), the inner top of the telescopic air bag (14) is uniformly fixed with a plurality of fixing rods (17), and the other end of each fixing rod (17) is fixed to the top of the circular table (11); the side wall of the circular truncated cone (11) is also provided with a plurality of powder one-way valves (15).
7. The process for preparing an indapamide sustained-release tablet according to claim 6, wherein: a plurality of first sliding grooves (18) are formed in the side wall of the pressing rod (6) along the length direction of the pressing rod (6), and a plurality of balls (19) are arranged on the inner wall of the through hole; the ball (19) is matched with the first sliding groove (18), so that the circular truncated cone (11) can move up and down on the pressure rod (6) through the matching of the first sliding groove (18) and the ball (19); the telescopic cover (12) completely covers the first sliding chute (18).
8. The process for preparing an indapamide sustained-release tablet according to claim 4, wherein: the bottom of the mold groove (2) is provided with a jacking mechanism, the jacking mechanism comprises an ejector rod (20) with one end extending out of the bottom of the mold groove (2) and extending out of the bottom of the conveyer belt (1), the other end of the ejector rod (20) extends into the mold groove (2), the end part of the ejector rod is fixed with an ejector head (21), the bottom of the mold groove (2) is provided with a groove (22) matched with the ejector head (21), and the top surface of the ejector head (21) is flush with the bottom surface of the mold groove (2); the bottom of mould type groove (2), with be provided with a plurality of bar groove (23) on the position of the bottom surface laminating of top (21), bar groove (23) center on ejector pin (20) evenly sets up, bar groove (23) bottom is fixed with third spring (24), the other end of third spring (24) is fixed the bottom surface of top (21).
9. The process for preparing an indapamide sustained-release tablet according to claim 4, wherein: the blanking mechanism comprises a storage box (25), a blanking pipe (26) is fixed at the bottom of the storage box (25), and a filler cover (27) is arranged at the other end of the blanking pipe (26); a separator (28) is arranged in the blanking pipe (26), so that two symmetrical cylindrical cavities (29) with the same diameter are formed in the blanking pipe (26), and powder flow meters are respectively arranged in the two cylindrical cavities (29); and a material distributing assembly is fixed at the bottom of the separator (28) at the communication part of the feeding pipe (26) and the filling cover (27).
10. The process for preparing an indapamide sustained-release tablet according to claim 9, wherein: the material distribution assembly comprises a triangular prism (30) with an equilateral triangle bottom surface, and the height of the triangular prism (30) is smaller than the diameter of the blanking pipe (26), so that the triangular prism (30) is just positioned in the pipe orifice of the blanking pipe (26); the side edges of the triangular prism (30) are fixed at the bottom of the separator (28), symmetrical barrier strips (31) are arranged on the side surfaces of the triangular prism (30), connecting columns (32) are fixed on the barrier strips (31), and the other ends of the connecting columns (32) are fixed at the inner top of the packing cover (27); two side surfaces of the triangular prism (30) are respectively positioned above the two die grooves (2).
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| CN113524769B (en) * | 2021-07-21 | 2024-02-27 | 合肥英太制药有限公司 | Medical neurology is with patent medicine film-making equipment |
| CN114570262A (en) * | 2022-03-03 | 2022-06-03 | 浙江益昇环境科技有限公司 | Manufacturing device and manufacturing method for rapidly dispersing bentonite |
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