CN111228412A - A Chinese medicinal plaster for treating acute and chronic pharyngitis, and its preparation method - Google Patents
A Chinese medicinal plaster for treating acute and chronic pharyngitis, and its preparation method Download PDFInfo
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- CN111228412A CN111228412A CN201811439327.3A CN201811439327A CN111228412A CN 111228412 A CN111228412 A CN 111228412A CN 201811439327 A CN201811439327 A CN 201811439327A CN 111228412 A CN111228412 A CN 111228412A
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- treating acute
- chronic pharyngitis
- chinese medicine
- traditional chinese
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- 201000007100 Pharyngitis Diseases 0.000 title claims abstract description 79
- 239000011505 plaster Substances 0.000 title claims abstract description 39
- 230000001154 acute effect Effects 0.000 title claims abstract description 37
- 208000016150 acute pharyngitis Diseases 0.000 title claims abstract description 37
- 238000002360 preparation method Methods 0.000 title claims description 14
- 239000003814 drug Substances 0.000 claims abstract description 38
- 229910052602 gypsum Inorganic materials 0.000 claims abstract description 34
- 239000010440 gypsum Substances 0.000 claims abstract description 34
- 239000004863 Frankincense Substances 0.000 claims abstract description 32
- 239000002994 raw material Substances 0.000 claims abstract description 26
- 235000003717 Boswellia sacra Nutrition 0.000 claims abstract description 25
- 235000012035 Boswellia serrata Nutrition 0.000 claims abstract description 25
- 240000007551 Boswellia serrata Species 0.000 claims abstract description 25
- DTGKSKDOIYIVQL-WEDXCCLWSA-N (+)-borneol Chemical compound C1C[C@@]2(C)[C@@H](O)C[C@@H]1C2(C)C DTGKSKDOIYIVQL-WEDXCCLWSA-N 0.000 claims abstract description 24
- REPVLJRCJUVQFA-UHFFFAOYSA-N (-)-isopinocampheol Natural products C1C(O)C(C)C2C(C)(C)C1C2 REPVLJRCJUVQFA-UHFFFAOYSA-N 0.000 claims abstract description 19
- 241000205585 Aquilegia canadensis Species 0.000 claims abstract description 19
- 235000017166 Bambusa arundinacea Nutrition 0.000 claims abstract description 19
- 235000017491 Bambusa tulda Nutrition 0.000 claims abstract description 19
- 240000007311 Commiphora myrrha Species 0.000 claims abstract description 19
- 235000006965 Commiphora myrrha Nutrition 0.000 claims abstract description 19
- 235000006679 Mentha X verticillata Nutrition 0.000 claims abstract description 19
- 235000002899 Mentha suaveolens Nutrition 0.000 claims abstract description 19
- 235000001636 Mentha x rotundifolia Nutrition 0.000 claims abstract description 19
- 235000007265 Myrrhis odorata Nutrition 0.000 claims abstract description 19
- 235000015334 Phyllostachys viridis Nutrition 0.000 claims abstract description 19
- 239000011425 bamboo Substances 0.000 claims abstract description 19
- 229940116229 borneol Drugs 0.000 claims abstract description 19
- CKDOCTFBFTVPSN-UHFFFAOYSA-N borneol Natural products C1CC2(C)C(C)CC1C2(C)C CKDOCTFBFTVPSN-UHFFFAOYSA-N 0.000 claims abstract description 19
- DTGKSKDOIYIVQL-UHFFFAOYSA-N dl-isoborneol Natural products C1CC2(C)C(O)CC1C2(C)C DTGKSKDOIYIVQL-UHFFFAOYSA-N 0.000 claims abstract description 19
- 229940099259 vaseline Drugs 0.000 claims abstract description 19
- 240000005528 Arctium lappa Species 0.000 claims abstract description 16
- 235000003130 Arctium lappa Nutrition 0.000 claims abstract description 16
- 241000219784 Sophora Species 0.000 claims abstract description 16
- 235000008078 Arctium minus Nutrition 0.000 claims abstract description 8
- 241000605445 Anemarrhena asphodeloides Species 0.000 claims abstract description 5
- 241000576429 Forsythia suspensa Species 0.000 claims abstract description 5
- 241000405414 Rehmannia Species 0.000 claims abstract description 5
- 241000207929 Scutellaria Species 0.000 claims abstract description 5
- 235000002226 Ranunculus ficaria Nutrition 0.000 claims abstract description 3
- 240000004534 Scutellaria baicalensis Species 0.000 claims abstract description 3
- 235000017089 Scutellaria baicalensis Nutrition 0.000 claims abstract description 3
- 244000082204 Phyllostachys viridis Species 0.000 claims abstract 5
- 244000081426 Ranunculus ficaria Species 0.000 claims abstract 2
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 51
- 239000002674 ointment Substances 0.000 claims description 40
- 239000000463 material Substances 0.000 claims description 28
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 27
- 238000002791 soaking Methods 0.000 claims description 26
- 238000002156 mixing Methods 0.000 claims description 25
- 239000000243 solution Substances 0.000 claims description 20
- 238000010438 heat treatment Methods 0.000 claims description 16
- 239000000706 filtrate Substances 0.000 claims description 15
- 238000000227 grinding Methods 0.000 claims description 15
- 239000007788 liquid Substances 0.000 claims description 15
- 238000001914 filtration Methods 0.000 claims description 10
- 238000003756 stirring Methods 0.000 claims description 10
- 239000011550 stock solution Substances 0.000 claims description 10
- AKEJUJNQAAGONA-UHFFFAOYSA-N sulfur trioxide Chemical compound O=S(=O)=O AKEJUJNQAAGONA-UHFFFAOYSA-N 0.000 claims description 10
- 239000006228 supernatant Substances 0.000 claims description 10
- 239000000126 substance Substances 0.000 claims description 9
- XOJVHLIYNSOZOO-SWOBOCGESA-N Arctiin Chemical compound C1=C(OC)C(OC)=CC=C1C[C@@H]1[C@@H](CC=2C=C(OC)C(O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@@H](CO)O3)O)=CC=2)C(=O)OC1 XOJVHLIYNSOZOO-SWOBOCGESA-N 0.000 claims description 8
- 241000717739 Boswellia sacra Species 0.000 claims description 7
- 241000628997 Flos Species 0.000 claims description 5
- 241001057584 Myrrha Species 0.000 claims description 5
- BRPQOXSCLDDYGP-UHFFFAOYSA-N calcium oxide Chemical compound [O-2].[Ca+2] BRPQOXSCLDDYGP-UHFFFAOYSA-N 0.000 claims description 5
- ODINCKMPIJJUCX-UHFFFAOYSA-N calcium oxide Inorganic materials [Ca]=O ODINCKMPIJJUCX-UHFFFAOYSA-N 0.000 claims description 5
- 239000000292 calcium oxide Substances 0.000 claims description 5
- 238000001816 cooling Methods 0.000 claims description 5
- 238000005485 electric heating Methods 0.000 claims description 5
- 239000000203 mixture Substances 0.000 claims description 5
- 239000002245 particle Substances 0.000 claims description 5
- 239000000843 powder Substances 0.000 claims description 5
- 230000001376 precipitating effect Effects 0.000 claims description 5
- 238000001556 precipitation Methods 0.000 claims description 5
- 238000005057 refrigeration Methods 0.000 claims description 5
- 238000007789 sealing Methods 0.000 claims description 5
- 238000005303 weighing Methods 0.000 claims description 5
- 238000000034 method Methods 0.000 claims 2
- 208000002193 Pain Diseases 0.000 abstract description 6
- 206010059866 Drug resistance Diseases 0.000 abstract description 5
- 231100000956 nontoxicity Toxicity 0.000 abstract description 3
- 231100000957 no side effect Toxicity 0.000 abstract description 2
- 206010068319 Oropharyngeal pain Diseases 0.000 abstract 1
- 230000000144 pharmacologic effect Effects 0.000 abstract 1
- 241001330002 Bambuseae Species 0.000 description 14
- 206010052428 Wound Diseases 0.000 description 4
- 208000027418 Wounds and injury Diseases 0.000 description 4
- 241001530126 Scrophularia Species 0.000 description 3
- 230000000694 effects Effects 0.000 description 3
- 208000024891 symptom Diseases 0.000 description 3
- 229920000175 Pistacia lentiscus Polymers 0.000 description 2
- 241000612118 Samolus valerandi Species 0.000 description 2
- 206010011224 Cough Diseases 0.000 description 1
- 206010060891 General symptom Diseases 0.000 description 1
- 206010062717 Increased upper airway secretion Diseases 0.000 description 1
- 206010061218 Inflammation Diseases 0.000 description 1
- 208000023668 Pharyngeal disease Diseases 0.000 description 1
- 206010037660 Pyrexia Diseases 0.000 description 1
- 206010057190 Respiratory tract infections Diseases 0.000 description 1
- 206010046306 Upper respiratory tract infection Diseases 0.000 description 1
- 206010047700 Vomiting Diseases 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 230000001680 brushing effect Effects 0.000 description 1
- 206010061428 decreased appetite Diseases 0.000 description 1
- 208000033420 disorder of pharynx Diseases 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 230000004054 inflammatory process Effects 0.000 description 1
- 210000003563 lymphoid tissue Anatomy 0.000 description 1
- 210000004877 mucosa Anatomy 0.000 description 1
- 208000026435 phlegm Diseases 0.000 description 1
- 208000023504 respiratory system disease Diseases 0.000 description 1
- 230000009747 swallowing Effects 0.000 description 1
- 230000008961 swelling Effects 0.000 description 1
- 210000004876 tela submucosa Anatomy 0.000 description 1
- 230000001988 toxicity Effects 0.000 description 1
- 231100000419 toxicity Toxicity 0.000 description 1
Classifications
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- A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
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- A61K36/18—Magnoliophyta (angiosperms)
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- A61K36/896—Liliaceae (Lily family), e.g. daylily, plantain lily, Hyacinth or narcissus
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- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0014—Skin, i.e. galenical aspects of topical compositions
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61P11/04—Drugs for disorders of the respiratory system for throat disorders
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- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation or decoction
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- A61K2236/50—Methods involving additional extraction steps
- A61K2236/51—Concentration or drying of the extract, e.g. Lyophilisation, freeze-drying or spray-drying
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- A61K2236/50—Methods involving additional extraction steps
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Abstract
The invention discloses a traditional Chinese medicine externally applied plaster for treating acute and chronic pharyngitis, which comprises the following raw materials in parts by weight: 10-20 parts of honeysuckle, 6-10 parts of fructus forsythiae, 6-10 parts of radix rehmanniae, 3-5 parts of radix scrophulariae, 7-9 parts of burdock, 10-12 parts of radix sophorae tonkinensis, 6-10 parts of rhizoma anemarrhenae, 10-20 parts of scutellaria baicalensis, 8-12 parts of frankincense, 8-12 parts of myrrh, 10-14 parts of mint, 7-9 parts of borneol, 1-3 parts of gypsum, 10-20 parts of bamboo leaves and 80-100 parts of vaseline. The plaster is prepared by the formula of honeysuckle flower, weeping forsythia, dried rehmannia root, figwort root, great burdock achene, subprostrate sophora, common anemarrhena rhizome, baical skullcap root, frankincense, myrrh, mint, borneol, gypsum, bamboo leaf and vaseline according to a proportion, has the pharmacological effects of clearing heat and detoxicating, relieving sore throat and dissipating binds, nourishing yin and moistening dryness and the like, is simple and easy to use and is easy to accept by patients; the traditional Chinese medicine externally applied plaster for treating acute and chronic pharyngitis has the advantages of no toxicity, no side effect, no drug resistance, no pain and no wound, is a necessary good medicine for vast pharyngitis patients, and has the cure rate of over 85 percent through the use observation and the feedback result of the patients for 2 to 3 years.
Description
Technical Field
The invention relates to the technical field of acute and chronic pharyngitis, in particular to a traditional Chinese medicine externally-applied plaster for treating the acute and chronic pharyngitis, and simultaneously relates to a preparation method of the traditional Chinese medicine externally-applied plaster for treating the acute and chronic pharyngitis.
Background
Acute and chronic pharyngitis mainly refers to diffuse inflammation of pharyngeal mucosa, submucosa and lymphoid tissue, is often accompanied by other upper respiratory diseases, and is a very common pharyngeal disease in people. The clinical symptoms mainly comprise red swelling and pain of throat, uncomfortable feeling during swallowing, excessive phlegm which is difficult to be completely coughed, speech which is easy to be tired, or nausea and vomiting when people frequently talk in tooth brushing and mouth rinsing, and the symptoms are mostly accompanied with upper respiratory tract infection symptoms such as fever and cough and general symptoms such as inappetence.
Aiming at the treatment of acute and chronic pharyngitis, the traditional external plaster has large side effect, poor patient acceptance and wound, and is easy to have drug resistance after being used for a long time, thereby bringing a lot of pain to patients.
Disclosure of Invention
The invention aims to provide a traditional Chinese medicine externally applied plaster for treating acute and chronic pharyngitis and a preparation method thereof, the application is simple and easy, and the plaster is easy to be accepted by patients; the medicine is a necessary good medicine for the majority of pharyngitis patients without toxicity, side effect, drug resistance, pain and wound, and solves the problems in the background technology.
In order to achieve the purpose, the invention provides the following technical scheme: a traditional Chinese medicine externally applied plaster for treating acute and chronic pharyngitis comprises the following raw materials in parts by weight: 10-20 parts of honeysuckle, 6-10 parts of fructus forsythiae, 6-10 parts of radix rehmanniae, 3-5 parts of radix scrophulariae, 7-9 parts of burdock, 10-12 parts of radix sophorae tonkinensis, 6-10 parts of rhizoma anemarrhenae, 10-20 parts of scutellaria baicalensis, 8-12 parts of frankincense, 8-12 parts of myrrh, 10-14 parts of mint, 7-9 parts of borneol, 1-3 parts of gypsum, 10-20 parts of bamboo leaves and 80-100 parts of vaseline.
Preferably, the water content of the raw materials of the honeysuckle, the weeping forsythia, the dried rehmannia root, the figwort root, the great burdock achene, the subprostrate sophora, the common anemarrhena rhizome, the baical skullcap root, the frankincense, the myrrh, the mint, the borneol, the gypsum and the bamboo leaf is not more than 10%.
Preferably, the mastic gum is an oval, drop-like mass, and the mastic gum has a length in the range of 2-5 cm.
Preferably, the gypsum is white powdery substance, and the content of calcium oxide in the gypsum is 32.6%, the content of sulfur trioxide is 46.5%, and the content of water is 20.9%.
The invention also provides a preparation method of the traditional Chinese medicine externally applied plaster for treating acute and chronic pharyngitis, which comprises the following steps:
s1: taking materials, weighing honeysuckle, fructus forsythiae, radix rehmanniae, radix scrophulariae, burdock, subprostrate sophora, rhizoma anemarrhenae, radix scutellariae, frankincense, myrrh, mint, borneol, gypsum, bamboo leaves and vaseline according to parts by weight for later use;
s2: grinding and mixing flos Lonicerae, fructus forsythiae, radix rehmanniae, radix scrophulariae, fructus Arctii, radix Sophorae Tonkinensis, rhizoma anemarrhenae, Scutellariae radix, Olibanum, Myrrha, herba Menthae, Borneolum Syntheticum and folium Bambusae into powder with a particle size of less than 150 meshes, and collecting the ground mixture;
s3: soaking, namely adding the mixed material ground in the step S2 and the gypsum into a soaking box to soak for 2-3h, wherein the soaking temperature is 15-25 ℃;
s4: decocting, namely decocting the materials soaked in the step S3 for three times, respectively decocting for 15-25min by slow fire once, decocting for 10-15min by strong fire twice and decocting for 15-25min by slow fire twice, and collecting three groups of decocted raw materials and stock solutions for later use;
s5: mixing filtrates, decocting the decoction materials and the stock solution in S4 for 30-40min, and naturally cooling to room temperature;
s6: filtering, namely filtering the raw materials and the liquid cooled in the step S5 under the condition that a filter screen is 100-150 meshes, and collecting the filtered filtrate for later use;
s7: concentrating, namely putting the filtrate obtained in the step S6 into a water bath kettle for heating and concentrating, wherein the heating temperature is 60-90 ℃, and the concentration is carried out to obtain an ointment with the relative density of 1.6-1.7;
s8: mixing, mixing vaseline and the concentrated ointment of S7, and stirring for 20-30 min;
s9: precipitating with ethanol, adding ethanol solution into the ointment mixed in S8 while stirring, wherein the amount of ethanol solution is equal to that of the ointment, and sealing and refrigerating for 24-48 h;
s10: and (3) standing, collecting the ointment, after the alcohol precipitation is finished, standing, sucking supernatant liquid by the ointment, continuing the concentration step in S7, and combining the ointment obtained from the supernatant liquid and the ointment after standing to obtain the traditional Chinese medicine externally applied plaster for treating acute and chronic pharyngitis.
Preferably, the grinding and mixing in the step S2 is performed by a WF series universal grinding mill, and the spindle rotation speed is 3000-4000 r/min.
Preferably, when the material is soaked in the step S3, the material is soaked in clear water, and the soaking depth is based on the condition that water overflows the top of the material by 2-3 cm.
Preferably, when the decoction is performed in the steps S4 and S5, the ratio of water to the raw materials is 4:1, and the decoction is heated by an electric heating tube.
Preferably, the concentration of the ethanol solution in the step S9 is 45-55%, and the temperature for closed refrigeration is 3-6 ℃.
Compared with the prior art, the invention has the beneficial effects that: the invention strictly controls the ratio of each component and the preparation process parameters of the traditional Chinese medicine external plaster for treating acute and chronic pharyngitis, and the plaster is prepared by the formulas of honeysuckle, weeping forsythia, dried rehmannia root, scrophularia, great burdock achene, subprostrate sophora, anemarrhena asphodeloides bunge, baical skullcap root, frankincense, myrrh, mint, borneol, gypsum, bamboo leaf and vaseline according to the proportion. In addition, the medicine is simple and easy to use and is easily accepted by patients; the traditional Chinese medicine externally applied plaster for treating acute and chronic pharyngitis has the advantages of no toxicity, no side effect, no drug resistance, no pain and no wound, is a necessary good medicine for vast pharyngitis patients, and has the cure rate of over 85 percent through the use observation and the feedback result of the patients for 2 to 3 years.
Detailed Description
In order to make the objects, technical solutions and advantages of the present invention more apparent, the present invention is further described in detail with reference to the following embodiments. It should be understood that the specific embodiments described herein are merely illustrative of the invention and are not intended to limit the invention.
The invention provides a traditional Chinese medicine externally applied plaster for treating acute and chronic pharyngitis, which comprises the following components in percentage by weight of the base materials in specific embodiments:
example 1
A traditional Chinese medicine externally applied plaster for treating acute and chronic pharyngitis comprises the following raw materials in parts by weight: 10 parts of honeysuckle, 6 parts of fructus forsythiae, 6 parts of radix rehmanniae, 3 parts of radix scrophulariae, 7 parts of great burdock achene, 10 parts of subprostrate sophora, 6 parts of rhizoma anemarrhenae, 10 parts of radix scutellariae, 8 parts of frankincense, 8 parts of myrrh, 10 parts of mint, 7 parts of borneol, 1 part of gypsum, 10 parts of bamboo leaves and 80 parts of vaseline, wherein the water content of the raw materials of the honeysuckle, the fructus forsythiae, the radix rehmanniae, the radix scrophulariae, the fructus arctii, the subprostrate sophora, the rhizoma anemarrhenae, the radix scutellariae, the frankincense, the myrrh, the mint, the borneol, the gypsum and the bamboo leaves is not more than 10 percent, the frankincense is a long oval drop milky substance, the length of the frankincense is 2cm, the gypsum is a white powdery substance, the content of calcium oxide in the gypsum is 32.6 percent, the content of sulfur trioxide is 46.5 percent, and the content of.
The invention also provides a preparation method of the traditional Chinese medicine externally applied plaster for treating acute and chronic pharyngitis, which comprises the following steps:
s1: taking materials, weighing honeysuckle, fructus forsythiae, radix rehmanniae, radix scrophulariae, burdock, subprostrate sophora, rhizoma anemarrhenae, radix scutellariae, frankincense, myrrh, mint, borneol, gypsum, bamboo leaves and vaseline according to parts by weight for later use;
s2: grinding and mixing flos Lonicerae, fructus forsythiae, radix rehmanniae, radix scrophulariae, fructus Arctii, radix Sophorae Tonkinensis, rhizoma anemarrhenae, Scutellariae radix, Olibanum, Myrrha, herba Menthae, Borneolum Syntheticum and folium Bambusae into powder with a particle size of less than 150 meshes, and collecting the ground mixture;
s3: soaking, namely adding the mixed material ground in the step S2 and the gypsum into a soaking box to soak for 2 hours at the soaking temperature of 15 ℃;
s4: decocting, namely decocting the materials soaked in the step S3 for three times, respectively decocting for 15min by slow fire once, 10min by strong fire and 15min by slow fire twice, and collecting three groups of decocted raw materials and stock solutions for later use;
s5: mixing filtrates, decocting the decoction materials and the stock solution in S4 for 30min, and naturally cooling to room temperature;
s6: filtering, namely filtering the raw materials and the liquid cooled in the step S5 under the condition that a filter screen is 100 meshes, and collecting the filtered filtrate for later use;
s7: concentrating, namely putting the filtrate obtained in the step S6 into a water bath kettle for heating and concentrating, wherein the heating temperature is 60 ℃, and the concentration is carried out to obtain an ointment with the relative density of 1.6;
s8: mixing, mixing vaseline and the concentrated ointment of S7, and stirring for 20 min;
s9: precipitating with ethanol, adding ethanol solution into the ointment mixed in S8 while stirring, wherein the amount of the ethanol solution is equal to that of the ointment, and sealing and refrigerating for 24 hr after the ethanol solution is added;
s10: and (3) standing, collecting the ointment, after the alcohol precipitation is finished, standing, sucking supernatant liquid by the ointment, continuing the concentration step in S7, and combining the ointment obtained from the supernatant liquid and the ointment after standing to obtain the traditional Chinese medicine externally applied plaster for treating acute and chronic pharyngitis.
The grinding and mixing in the step S2 are carried out by adopting a WF series universal grinding mill, the rotating speed of a main shaft is 3000r/min, when the step S3 is carried out, clear water is adopted for soaking, the soaking depth is based on that water overflows the top of the material by 2m, when the steps S4 and S5 are carried out, the ratio of water to raw materials is 4:1, the decocting heating mode adopts an electric heating pipe heating mode, the concentration of the ethanol solution in the step S9 is 45%, and the sealed refrigeration temperature is 3 ℃.
Example 2
A traditional Chinese medicine externally applied plaster for treating acute and chronic pharyngitis comprises the following raw materials in parts by weight: 15 parts of honeysuckle, 8 parts of fructus forsythiae, 8 parts of radix rehmanniae, 4 parts of radix scrophulariae, 8 parts of great burdock achene, 11 parts of subprostrate sophora, 8 parts of rhizoma anemarrhenae, 15 parts of radix scutellariae, 10 parts of frankincense, 10 parts of myrrh, 12 parts of mint, 8 parts of borneol, 2 parts of gypsum, 15 parts of bamboo leaves and 90 parts of vaseline, wherein the water content of the raw materials of the honeysuckle, the fructus forsythiae, the radix rehmanniae, the radix scrophulariae, the fructus arctii, the subprostrate sophora, the rhizoma anemarrhenae, the radix scutellariae, the frankincense, the myrrh, the mint, the borneol, the gypsum and the bamboo leaves is not more than 10 percent, the frankincense is a long oval drop milky substance, the length of the frankincense is 3.5cm, the gypsum is a white powdery substance, the content of calcium oxide in the gypsum is 32.6 percent, the content of sulfur trioxide is 46.5 percent, and the content of.
The invention also provides a preparation method of the traditional Chinese medicine externally applied plaster for treating acute and chronic pharyngitis, which comprises the following steps:
s1: taking materials, weighing honeysuckle, fructus forsythiae, radix rehmanniae, radix scrophulariae, burdock, subprostrate sophora, rhizoma anemarrhenae, radix scutellariae, frankincense, myrrh, mint, borneol, gypsum, bamboo leaves and vaseline according to parts by weight for later use;
s2: grinding and mixing flos Lonicerae, fructus forsythiae, radix rehmanniae, radix scrophulariae, fructus Arctii, radix Sophorae Tonkinensis, rhizoma anemarrhenae, Scutellariae radix, Olibanum, Myrrha, herba Menthae, Borneolum Syntheticum and folium Bambusae into powder with a particle size of less than 150 meshes, and collecting the ground mixture;
s3: soaking, namely adding the mixed material ground in the step S2 and the gypsum into a soaking box to soak for 2.5 hours at the soaking temperature of 20 ℃;
s4: decocting, namely decocting the materials soaked in the step S3 for three times, respectively decocting for 20min by slow fire once, 12.5min by strong fire and 20min by slow fire twice, and collecting three groups of decocted raw materials and stock solutions for later use;
s5: mixing filtrates, decocting the decoction materials and stock solution in S4 for 35min, and naturally cooling to room temperature;
s6: filtering, namely filtering the raw materials and the liquid cooled in the step S5 under the condition that a filter screen is 125 meshes, and collecting the filtered filtrate for later use;
s7: concentrating, namely putting the filtrate obtained in the step S6 into a water bath kettle for heating and concentrating, wherein the heating temperature is 75 ℃, and the concentration is carried out to obtain an ointment with the relative density of 1.65;
s8: mixing, mixing vaseline and the concentrated ointment of S7, and stirring for 25 min;
s9: precipitating with ethanol, adding ethanol solution into the ointment mixed in S8 while stirring, wherein the amount of the ethanol solution is equal to that of the ointment, and sealing and refrigerating for 36h after the ethanol solution is added;
s10: and (3) standing, collecting the ointment, after the alcohol precipitation is finished, standing, sucking supernatant liquid by the ointment, continuing the concentration step in S7, and combining the ointment obtained from the supernatant liquid and the ointment after standing to obtain the traditional Chinese medicine externally applied plaster for treating acute and chronic pharyngitis.
The grinding and mixing in the step S2 are carried out by adopting a WF series universal grinding grinder, the rotating speed of a main shaft is 3500r/min, when the soaking is carried out in the step S3, clear water is adopted for soaking, the soaking depth is based on the condition that water overflows the top of the material by 2.5cm, when the decoction is carried out in the steps S4 and S5, the ratio of the water to the raw material is 4:1, the decoction heating mode adopts an electric heating pipe heating mode, the concentration of the ethanol solution in the step S9 is 50%, and the closed refrigeration temperature is 4.5 ℃.
Example 3
A traditional Chinese medicine externally applied plaster for treating acute and chronic pharyngitis comprises the following raw materials in parts by weight: 20 parts of honeysuckle, 10 parts of fructus forsythiae, 10 parts of radix rehmanniae, 5 parts of radix scrophulariae, 9 parts of great burdock achene, 12 parts of subprostrate sophora, 10 parts of rhizoma anemarrhenae, 20 parts of radix scutellariae, 12 parts of frankincense, 12 parts of myrrh, 14 parts of mint, 9 parts of borneol, 3 parts of gypsum, 20 parts of bamboo leaves and 100 parts of vaseline, wherein the water content of the raw materials of the honeysuckle, the fructus forsythiae, the radix rehmanniae, the radix scrophulariae, the fructus arctii, the subprostrate sophora, the rhizoma anemarrhenae, the radix scutellariae, the frankincense, the myrrh, the mint, the borneol, the gypsum and the bamboo leaves is not more than 10 percent, the frankincense is a long oval drop milky substance, the length of the frankincense is 5cm, the gypsum is a white powdery substance, the content of calcium oxide in the gypsum is 32.6 percent, the content of sulfur trioxide is 46.5 percent, and the content of.
The invention also provides a preparation method of the traditional Chinese medicine externally applied plaster for treating acute and chronic pharyngitis, which comprises the following steps:
s1: taking materials, weighing honeysuckle, fructus forsythiae, radix rehmanniae, radix scrophulariae, burdock, subprostrate sophora, rhizoma anemarrhenae, radix scutellariae, frankincense, myrrh, mint, borneol, gypsum, bamboo leaves and vaseline according to parts by weight for later use;
s2: grinding and mixing flos Lonicerae, fructus forsythiae, radix rehmanniae, radix scrophulariae, fructus Arctii, radix Sophorae Tonkinensis, rhizoma anemarrhenae, Scutellariae radix, Olibanum, Myrrha, herba Menthae, Borneolum Syntheticum and folium Bambusae into powder with a particle size of less than 150 meshes, and collecting the ground mixture;
s3: soaking, namely adding the mixed material ground in the step S2 and the gypsum into a soaking box to soak for 3 hours at the soaking temperature of 25 ℃;
s4: decocting, namely decocting the materials soaked in the step S3 for three times, respectively decocting for 25min by slow fire once, 15min by strong fire and 25min by slow fire twice, and collecting three groups of decocted raw materials and stock solutions for later use;
s5: mixing filtrates, decocting the decoction materials and the stock solution in S4 for 40min, and naturally cooling to room temperature;
s6: filtering, namely filtering the raw material and the liquid cooled in the step S5 under the condition that a filter screen is 150 meshes, and collecting the filtered filtrate for later use;
s7: concentrating, namely putting the filtrate obtained in the step S6 into a water bath kettle for heating and concentrating, wherein the heating temperature is 90 ℃, and the concentration is carried out to obtain an ointment with the relative density of 1.7;
s8: mixing, mixing vaseline and the concentrated ointment of S7, and stirring for 30 min;
s9: precipitating with ethanol, adding ethanol solution into the ointment mixed in S8 while stirring, wherein the amount of the ethanol solution is equal to that of the ointment, and sealing and refrigerating for 48h after the ethanol solution is added;
s10: and (3) standing, collecting the ointment, after the alcohol precipitation is finished, standing, sucking supernatant liquid by the ointment, continuing the concentration step in S7, and combining the ointment obtained from the supernatant liquid and the ointment after standing to obtain the traditional Chinese medicine externally applied plaster for treating acute and chronic pharyngitis.
The grinding and mixing in the step S2 are carried out by adopting a WF series universal grinding mill, the rotating speed of a main shaft is 4000r/min, when the step S3 is carried out, clear water is adopted for soaking, the soaking depth is based on that water overflows the top of the material by 3cm, when the steps S4 and S5 are carried out, the ratio of water to raw materials is 4:1, the decocting heating mode adopts an electric heating pipe heating mode, the concentration of an ethanol solution in the step S9 is 55%, and the sealed refrigeration temperature is 6 ℃.
The decoction time and specific embodiment data of the traditional Chinese medicine externally applied plaster for treating acute and chronic pharyngitis provided by the invention are as follows in the following table 1:
in summary, the following steps: the invention strictly controls the ratio of each component and the preparation process parameters of the traditional Chinese medicine external plaster for treating acute and chronic pharyngitis, and the plaster is prepared by the formulas of honeysuckle, weeping forsythia, dried rehmannia root, scrophularia, great burdock achene, subprostrate sophora, anemarrhena asphodeloides bunge, baical skullcap root, frankincense, myrrh, mint, borneol, gypsum, bamboo leaf and vaseline according to the proportion. In addition, the medicine is simple and easy to use and is easily accepted by patients; has no toxicity, side effect, drug resistance, pain and wound, and is a necessary good medicine for the patients with pharyngitis.
The above description is only for the preferred embodiment of the present invention, but the scope of the present invention is not limited thereto, and any person skilled in the art should be considered to be within the technical scope of the present invention, and the technical solutions and the inventive concepts thereof according to the present invention should be equivalent or changed within the scope of the present invention.
Claims (9)
1. A traditional Chinese medicine externally applied plaster for treating acute and chronic pharyngitis is characterized in that: the raw materials are as follows by weight: 10-20 parts of honeysuckle, 6-10 parts of fructus forsythiae, 6-10 parts of radix rehmanniae, 3-5 parts of radix scrophulariae, 7-9 parts of burdock, 10-12 parts of radix sophorae tonkinensis, 6-10 parts of rhizoma anemarrhenae, 10-20 parts of scutellaria baicalensis, 8-12 parts of frankincense, 8-12 parts of myrrh, 10-14 parts of mint, 7-9 parts of borneol, 1-3 parts of gypsum, 10-20 parts of bamboo leaves and 80-100 parts of vaseline.
2. The traditional Chinese medicine externally applied plaster for treating acute and chronic pharyngitis according to claim 1, which is characterized in that: the water content of the raw materials of the honeysuckle, the weeping forsythia, the dried rehmannia root, the figwort root, the great burdock achene, the subprostrate sophora, the common anemarrhena rhizome, the baical skullcap root, the frankincense, the myrrh, the mint, the borneol, the gypsum and the bamboo leaf is not more than 10 percent.
3. The traditional Chinese medicine externally applied plaster for treating acute and chronic pharyngitis according to claim 1, which is characterized in that: the Olibanum is long oval drop milky substance, and the length of Olibanum is 2-5 cm.
4. The traditional Chinese medicine externally applied plaster for treating acute and chronic pharyngitis according to claim 1, which is characterized in that: the gypsum is white powdery substance, and the content of calcium oxide in the gypsum is 32.6%, the content of sulfur trioxide is 46.5%, and the content of water is 20.9%.
5. A method for preparing the Chinese medicinal external plaster for treating acute and chronic pharyngitis according to claim 1, which is characterized in that: the method comprises the following steps:
s1: taking materials, weighing honeysuckle, fructus forsythiae, radix rehmanniae, radix scrophulariae, burdock, subprostrate sophora, rhizoma anemarrhenae, radix scutellariae, frankincense, myrrh, mint, borneol, gypsum, bamboo leaves and vaseline according to parts by weight for later use;
s2: grinding and mixing flos Lonicerae, fructus forsythiae, radix rehmanniae, radix scrophulariae, fructus Arctii, radix Sophorae Tonkinensis, rhizoma anemarrhenae, Scutellariae radix, Olibanum, Myrrha, herba Menthae, Borneolum Syntheticum and folium Bambusae into powder with a particle size of less than 150 meshes, and collecting the ground mixture;
s3: soaking, namely adding the mixed material ground in the step S2 and the gypsum into a soaking box to soak for 2-3h, wherein the soaking temperature is 15-25 ℃;
s4: decocting, namely decocting the materials soaked in the step S3 for three times, respectively decocting for 15-25min by slow fire once, decocting for 10-15min by strong fire twice and decocting for 15-25min by slow fire twice, and collecting three groups of decocted raw materials and stock solutions for later use;
s5: mixing filtrates, decocting the decoction materials and the stock solution in S4 for 30-40min, and naturally cooling to room temperature;
s6: filtering, namely filtering the raw materials and the liquid cooled in the step S5 under the condition that a filter screen is 100-150 meshes, and collecting the filtered filtrate for later use;
s7: concentrating, namely putting the filtrate obtained in the step S6 into a water bath kettle for heating and concentrating, wherein the heating temperature is 60-90 ℃, and the concentration is carried out to obtain an ointment with the relative density of 1.6-1.7;
s8: mixing, mixing vaseline and the concentrated ointment of S7, and stirring for 20-30 min;
s9: precipitating with ethanol, adding ethanol solution into the ointment mixed in S8 while stirring, wherein the amount of ethanol solution is equal to that of the ointment, and sealing and refrigerating for 24-48 h;
s10: and (3) standing, collecting the ointment, after the alcohol precipitation is finished, standing, sucking supernatant liquid by the ointment, continuing the concentration step in S7, and combining the ointment obtained from the supernatant liquid and the ointment after standing to obtain the traditional Chinese medicine externally applied plaster for treating acute and chronic pharyngitis.
6. The preparation method of the traditional Chinese medicine externally applied plaster for treating acute and chronic pharyngitis according to claim 5 is characterized in that: in the step S2, a WF series universal grinding mill is adopted for grinding and mixing, and the rotating speed of a main shaft is 3000-4000 r/min.
7. The preparation method of the traditional Chinese medicine externally applied plaster for treating acute and chronic pharyngitis according to claim 5 is characterized in that: and in the step S3, when soaking, soaking with clear water, wherein the soaking depth is based on the condition that water overflows the top of the material by 2-3 cm.
8. The preparation method of the traditional Chinese medicine externally applied plaster for treating acute and chronic pharyngitis according to claim 5 is characterized in that: when the decoction is carried out in the steps S4 and S5, the ratio of water to raw materials is 4:1, and the decoction is heated by an electric heating pipe.
9. The preparation method of the traditional Chinese medicine externally applied plaster for treating acute and chronic pharyngitis according to claim 5 is characterized in that: in the step S9, the concentration of the ethanol solution is 45-55%, and the temperature for closed refrigeration is 3-6 ℃.
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Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1349821A (en) * | 2001-11-01 | 2002-05-22 | 赵健忠 | Pharyngitis treating Chinese medicine plaster |
| CN101342328A (en) * | 2008-08-19 | 2009-01-14 | 宫兆荣 | Traditional Chinese medicine composing prescription for treating children's bacterial upper respiratory tract infection |
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2018
- 2018-11-29 CN CN201811439327.3A patent/CN111228412A/en active Pending
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1349821A (en) * | 2001-11-01 | 2002-05-22 | 赵健忠 | Pharyngitis treating Chinese medicine plaster |
| CN101342328A (en) * | 2008-08-19 | 2009-01-14 | 宫兆荣 | Traditional Chinese medicine composing prescription for treating children's bacterial upper respiratory tract infection |
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