CN111213909A - A cigarette containing flos Chrysanthemi extract and capable of reducing oral risk - Google Patents
A cigarette containing flos Chrysanthemi extract and capable of reducing oral risk Download PDFInfo
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- CN111213909A CN111213909A CN202010073782.7A CN202010073782A CN111213909A CN 111213909 A CN111213909 A CN 111213909A CN 202010073782 A CN202010073782 A CN 202010073782A CN 111213909 A CN111213909 A CN 111213909A
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- A—HUMAN NECESSITIES
- A24—TOBACCO; CIGARS; CIGARETTES; SIMULATED SMOKING DEVICES; SMOKERS' REQUISITES
- A24D—CIGARS; CIGARETTES; TOBACCO SMOKE FILTERS; MOUTHPIECES FOR CIGARS OR CIGARETTES; MANUFACTURE OF TOBACCO SMOKE FILTERS OR MOUTHPIECES
- A24D1/00—Cigars; Cigarettes
- A24D1/002—Cigars; Cigarettes with additives, e.g. for flavouring
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Abstract
The invention relates to a heating cigarette added with chrysanthemum extract and capable of reducing oral risks, and belongs to the technical field of tobacco cigarettes. The heated cigarette comprises the following components in parts by weight: 30-70 parts of tobacco raw materials, 10-30 parts of smoke agents, 10-50 parts of non-combustible inorganic fillers, 5-20 parts of adhesives, 1-20 parts of essences and spices and 5-20 parts of chrysanthemum extracts; the preparation method of the chrysanthemum extract comprises the steps of crushing chrysanthemum, extracting for many times by using ultrapure water in a shaking way, combining extracting solutions, centrifuging at 4 ℃, taking supernate, freeze-drying the supernate and storing for later use to obtain the chrysanthemum extract. The invention discovers that when people smoke the heating type cigarettes for a long time, high-concentration smoke can cause cell death, and the chrysanthemum extract added into the cigarettes can improve the cell death caused by the high-concentration smoke, and can obviously reduce the oral risk caused by smoking and heating the cigarettes.
Description
Technical Field
The invention belongs to the technical field of tobacco cigarette cigarettes, and particularly relates to a heating cigarette which is added with a chrysanthemum extract and can reduce oral risks.
Background
In the beginning of the last 21 st century of the 20 th century, with the signing and the taking effect of the tobacco control framework convention (FCTC), the fourth global tobacco banning tide is raised, the form of the tobacco control movement is promoted to be organized and planned unified actions in a global range by the behaviors of individuals, organizations or countries, and the tobacco banning tide is rolling around every corner of the world. By far, the world health organization "tobacco control framework convention" has reached 177 contracting countries, covering 88% of the population worldwide. Meanwhile, with the continuous improvement of living standard of people, people pay more attention to physical and mental health and environmental protection of people, and have new knowledge on tobacco. In order to deal with the former situation, various big tobacco groups abroad invest huge resources, new technologies and new product researches and developments, and the novel tobacco products can be developed rapidly.
A cigarette (new cigarette or low-temperature cigarette) without combustion is a new tobacco product which heats tobacco shreds by using a special heat source (below 500 ℃ or even lower) but does not burn the tobacco shreds. Domestic and foreign researches show that the release amount of harmful components in tobacco smoke is closely related to heating and burning temperatures, and the release amount of the harmful components in the smoke can be obviously reduced by reducing the heating or burning temperatures. The novel cigarette product is filled with tobacco substances and has the appearance of a traditional cigarette, but the traditional cigarette combustion mode is changed, and nicotine and fragrance are transmitted to a human body in a mode of only heating and not combusting to generate visible smoke. Compared with electronic cigarettes and smokeless tobacco products, the cigarette which is not combusted by heating is closest to the traditional cigarette in the aspects of physiological sensation, psychological perception, smoking mode and the like, and has obvious harm reduction characteristics, such as almost no generation of 'second-hand smoke', very little visible main smoke, great reduction of the types and the intake of harmful substances ingested by smokers, and good development potential. The mouth is the organ that the body first contacts food and begins to digest. In the oral epithelium, most parts do not have a cornified layer (compared with the skin) and a mucus layer formed by mucus (compared with the gastrointestinal tract), so that the oral epithelial cells are directly exposed to the external environment, and oral discomfort occurs when a part of substances in cigarette smoke causes death of the epithelial cells. Although the irritation to the oral cavity is greatly reduced compared with the traditional cigarette, the cigarette which is not combusted by heating still has certain irritation.
The chrysanthemum is a short-day plant and can bloom in advance under short day. Preference to sunlight, contraindication to shade, better resistance to early age and fear of waterlogging. It is fond of warm and humid climate, but it is also cold resistant, and the rhizome can overwinter underground in severe winter. Flowers can endure frosting, but higher temperature is needed in the seedling growth and the bud-pregnancy period of the branch. The medicinal part of the chrysanthemum is dried head-shaped flower floc of the plant. The flos Chrysanthemi has effects of treating wind-heat type common cold, headache giddiness, conjunctival congestion, swelling and pain, dim eyesight, sore, carbuncle, and toxic swelling. For example, SANGJUYIN (dialectical for epidemic febrile disease), LINGJIAOramulus Uncariae cum uncis decoction (popular treatise on exogenous febrile disease), QIJUDIHUANG pill (medical grade), and CHAIMUYIN decoction (DIEDOGUDE).
How to prepare a heating cigarette added with chrysanthemum extract and capable of reducing oral risks so as to overcome the defects of the prior art is a problem to be solved urgently in the technical field of tobacco cigarette at present.
Disclosure of Invention
The invention aims to solve the defects of the prior art and provide a heated cigarette added with chrysanthemum extract and capable of reducing oral risks. The invention discovers that when people smoke the heated cigarette for a long time, oral cells are exposed in high-concentration smoke to cause cell death, and the chrysanthemum extract is added into the total particulate matter of the heated non-combustible smoke to improve the cell death caused by the total particulate matter, so that the oral risk caused by smoking the heated cigarette can be obviously reduced. The chrysanthemum extract can be directly added into the cigarette without burning, so that the death of oral cells caused by using the cigarette without burning can be reduced.
In order to achieve the purpose, the technical scheme adopted by the invention is as follows:
a heating cigarette added with chrysanthemum extract and capable of reducing oral risks comprises the following components in parts by weight:
30-70 parts of tobacco raw materials, 10-30 parts of smoke agents, 10-50 parts of non-combustible inorganic fillers, 5-20 parts of adhesives, 1-20 parts of essences and spices and 5-20 parts of chrysanthemum extracts;
the tobacco raw material is reconstituted tobacco or a composition of the reconstituted tobacco and cut tobacco;
the preparation method of the chrysanthemum extract comprises the steps of crushing chrysanthemum, extracting for many times by using ultrapure water in a shaking way, combining extracting solutions, centrifuging at 4 ℃, taking supernate, freeze-drying the supernate and storing for later use to obtain the chrysanthemum extract.
The extraction times of the invention are preferably 3-8 times.
Further, preferably, the reconstituted tobacco is made of one or more of flue-cured tobacco, sun-cured tobacco and burley tobacco; the reconstituted tobacco is made of one or more of tobacco leaves, tobacco shreds and tobacco stems.
Further, preferably, the reconstituted tobacco manufacturing method is a roll-pressing method, a paper-making method or a thick pulp method.
Further, preferably, the smoke agent is one or a mixture of propylene glycol, glycerol, triethylene glycol, sorbitol, xylitol and ethylene glycol.
Further, it is preferred that the non-combustible inorganic filler is a mixture of one or more of calcium carbonate, magnesium oxide, magnesium sulphate, silica, chalk, perlite, diatomaceous earth.
Further, it is preferable that the binder is an organic binder and/or a non-combustible inorganic binder.
Further, it is preferable that the organic binder is methyl cellulose, ethyl cellulose, carboxymethyl cellulose, acetyl cellulose, alginic acid binder, pectin binder or gel; the incombustible inorganic binder is potassium silicate or magnesium oxide.
further, preferably, the essence is one or more of coffee extract, vanillin, megastigmatrienone, solanone, licorice, coffee, β -damascenone and tobacco extract.
Further, preferably, the number of extraction times is 3, each time of ultrapure water oscillation extraction is 20 minutes, and the usage ratio of the chrysanthemum to each time of ultrapure water is as follows: 1000 g: 200 ml: 1000 ml: 500 ml; the centrifugation parameters were 13000g for 30 minutes; the freeze-drying temperature is-30 deg.C, and the freeze-drying time is 22 hr.
The invention also provides application of the chrysanthemum extract in preparing medicines, health-care products and tobacco products for preventing and treating oral epithelial cell death caused by osmotic pressure.
The production process of the reconstituted tobacco can be as follows:
and (3) rolling: the tobacco shred is prepared by crushing tobacco materials such as tobacco powder, stems and the like, mixing the crushed tobacco materials with materials such as an adhesive, a humectant, water and the like according to a certain proportion, uniformly stirring the mixture to form loose granular shapes, rolling the granular shapes by a rolling machine to form sheets, drying the sheets, and finally cutting the sheets into the reconstituted tobacco with a certain specification or directly cutting the sheets into the reconstituted tobacco shreds by a reconstituted tobacco shredder.
A papermaking method: by means of paper making technology and equipment, the tobacco material is first soaked and extracted in warm water, the soluble matter is separated from fiber and insoluble matter, the fiber and insoluble matter are then pulped and formed in paper making machine, the soluble matter is extracted and concentrated, sprayed back to the forming substrate, dried and cut into reconstituted tobacco.
Thick slurry method: the tobacco material is crushed and then mixed into the aqueous solution with the adhesive and the humectant, the mixture is stirred uniformly to form paste, then the thick matter is spread on an annular stainless steel belt to be dried, and the reconstituted tobacco is formed after the thick matter is peeled off.
The special reconstituted tobacco processed by the pretreatment process and heated and non-combustible to form the core material is processed by the gathering process of the paper filter stick, the dry reconstituted tobacco is cut into strips and shreds into a horizontal half-broken and longitudinal continuous state by utilizing a strip and shred cutting process and equipment thereof, and then a base rod with the length of 120mm is prepared by a paper-based filter stick forming machine. Then the special cigarette which can be adapted to the smoking set is obtained through the compounding and forming process and the filter stick compounding and the cutting process.
Compared with the prior art, the invention has the beneficial effects that:
1. the invention discovers that smoke can cause the death of oral epithelial cells when people smoke and heat cigarettes for a long time, and the chrysanthemum extract added into cigarettes can obviously reduce the oral risk caused by smoking and heating cigarettes, namely obviously reduce the death rate of oral cells.
2. The heating cigarette can greatly improve the condition that the oral epithelial cells die due to the generation of a hypertonic environment in the conventional heating cigarette, and can obviously reduce the oral risk caused by heating the cigarette.
Drawings
FIG. 1 is a graph showing the results of cell death inhibition by addition of chrysanthemum extract during culture. **: t-test P < 0.01; the results show that: the addition of the chrysanthemum extract can reduce the death of oral epithelial cells caused by heating and non-combustion of cigarette smoke total particulate matters.
FIG. 2 is a graph showing the results of suppressing cell death by adding chrysanthemum extract directly to tobacco smoke; the results show that: the chrysanthemum extract is directly added in the manufacturing process of the cigarette without heating combustion, and compared with the cigarette without heating combustion without adding the chrysanthemum extract, the proportion of cell death induced by the total particulate matter in the smoke is reduced.
Detailed Description
The present invention will be described in further detail with reference to examples.
It will be appreciated by those skilled in the art that the following examples are illustrative of the invention only and should not be taken as limiting the scope of the invention. The examples do not specify particular techniques or conditions, and are performed according to the techniques or conditions described in the literature in the art or according to the product specifications. The materials or equipment used are not indicated by manufacturers, and all are conventional products available by purchase.
The following examples are not specifically described, and the percentages are by weight and the proportions are by mass.
Example 1
A heating cigarette added with chrysanthemum extract and capable of reducing oral risks comprises the following components in parts by weight:
30 parts of tobacco raw materials, 10 parts of smoke generating agent, 10 parts of non-combustible inorganic filler, 5 parts of adhesive, 1 part of essence and spice and 5 parts of chrysanthemum extract;
the tobacco raw material is reconstituted tobacco;
the preparation method of the chrysanthemum extract comprises the steps of crushing chrysanthemum, extracting for many times by using ultrapure water in a shaking way, combining extracting solutions, centrifuging at 4 ℃, taking supernate, freeze-drying the supernate and storing for later use to obtain the chrysanthemum extract.
Example 2
A heating cigarette added with chrysanthemum extract and capable of reducing oral risks comprises the following components in parts by weight:
30 parts of tobacco raw materials, 10 parts of smoke generating agent, 10 parts of non-combustible inorganic filler, 5 parts of adhesive, 1 part of essence and spice and 5 parts of chrysanthemum extract;
the tobacco raw material is a composition of reconstituted tobacco and cut tobacco (the mass ratio is 19: 1);
the preparation method of the chrysanthemum extract comprises the steps of crushing chrysanthemum, extracting for many times by using ultrapure water in a shaking way, combining extracting solutions, centrifuging at 4 ℃, taking supernate, freeze-drying the supernate and storing for later use to obtain the chrysanthemum extract.
The reconstituted tobacco is prepared from flue-cured tobacco leaves and tobacco stems (the mass ratio is 2: 1).
The manufacturing method of the reconstituted tobacco is a rolling method.
The smoke agent is triethylene glycol.
The non-combustible inorganic filler is magnesium oxide.
The binder is methylcellulose.
The essence is coffee extract.
Example 3
A heating cigarette added with chrysanthemum extract and capable of reducing oral risks comprises the following components in parts by weight:
70 parts of tobacco raw materials, 30 parts of smoke agents, 50 parts of non-combustible inorganic fillers, 20 parts of adhesives, 20 parts of essences and spices and 20 parts of chrysanthemum extracts;
the tobacco raw material is reconstituted tobacco;
the preparation method of the chrysanthemum extract comprises the steps of crushing chrysanthemum, extracting for many times by using ultrapure water in a shaking way, combining extracting solutions, centrifuging at 4 ℃, taking supernate, freeze-drying the supernate and storing for later use to obtain the chrysanthemum extract.
The reconstituted tobacco is made of sun-cured tobacco and burley tobacco.
The manufacturing method of the reconstituted tobacco is a paper-making method.
The smoke agent is sorbitol and xylitol (mass ratio is 1: 1).
The incombustible inorganic filler is magnesium sulfate, silica and chalk (mass ratio is 2: 1: 1).
The binder is magnesium oxide.
The essence and the spice are liquorice extracts.
Example 4
A heating cigarette added with chrysanthemum extract and capable of reducing oral risks comprises the following components in parts by weight:
50 parts of tobacco raw materials, 20 parts of smoke agents, 30 parts of non-combustible inorganic fillers, 10 parts of adhesives, 12 parts of essences and spices and 15 parts of chrysanthemum extracts;
the tobacco raw material is reconstituted tobacco;
the preparation method of the chrysanthemum extract comprises the steps of crushing chrysanthemum, extracting for many times by using ultrapure water in a shaking way, combining extracting solutions, centrifuging at 4 ℃, taking supernate, freeze-drying the supernate and storing for later use to obtain the chrysanthemum extract.
The extraction frequency is 3 times, each time of ultrapure water oscillation extraction is 20 minutes, and the usage ratio of the chrysanthemum to each time of ultrapure water is as follows: 1000 g: 200 ml: 1000 ml: 500 ml; the centrifugation parameters were 13000g for 30 minutes; the freeze-drying temperature is-30 deg.C, and the freeze-drying time is 22 hr.
The reconstituted tobacco is prepared from flue-cured tobacco leaves, cut tobacco of air-cured tobacco and tobacco stems of burley tobacco (mass ratio is 1: 1: 1).
The manufacturing method of the reconstituted tobacco is a thick pulp method.
The smoke agent is glycol.
The non-combustible inorganic filler is diatomite.
The adhesive is acetyl cellulose and potassium silicate (the mass ratio is 3: 1).
the essence and flavor are coffee, β -damascenone and tobacco extract (mass ratio is 2: 1: 1).
Application example 1
1. A cigarette containing flos Chrysanthemi extract and capable of reducing oral risk
a. Tobacco leaves of Yunnan flue-cured tobacco (B2F) (30%), Fujian flue-cured tobacco (C3F) (30%), Yunnan sun-cured yellow tobacco (20%) and Turkey aromatic tobacco (20%) are made into reconstituted tobacco leaves by a paper-making method.
b. Preparation of chrysanthemum extract
(1) Weighing 1000g of chrysanthemum, crushing, and extracting once by shaking with 200ml, 1000ml and 500ml of ultrapure water respectively, wherein the extraction time is 20 hours each time.
(2) The combined extracts were subjected to high-speed refrigerated centrifugation (13000 g, 30 minutes at 4 ℃ C.), and the supernatant was collected and the precipitate was discarded.
(3) Freeze-drying the supernatant and storing for later use to obtain the chrysanthemum extract, wherein the freeze-drying conditions are as follows: 22 hours at-30 ℃.
c. The reconstituted tobacco is made into a heating cigarette after being shredded and rolled, and the heating cigarette comprises the following components in parts by weight: 50 parts of reconstituted tobacco, 10 parts of propylene glycol, 10 parts of glycerol, 10 parts of calcium carbonate, 5 parts of pectin, 2 parts of vanillin, 2 parts of megastigmatrienone, 6 parts of chrysanthemum extract and 5 parts of potassium silicate.
2. Extraction of smoke total particulate matter
The heated cigarettes were smoked and tested according to standard methods of GB16450-2004, GB 19609-2004. And balancing the heated cigarettes in a constant temperature and humidity box for 48 hours, and selecting cigarettes with consistent weight and suction resistance. According to the standard method, 20 cigarettes are respectively sucked on the full-automatic rotary disc type smoking machine, and the Cambridge filter disc in the Cambridge filter disc catcher is used for catching the total particulate matters of the smoke. Soaking Cambridge filter in MCDB151, ultrasonic extracting for 20 min, diluting to 10 mg TPM/ml DMSO, and storing at-80 deg.C.
3. Oral epithelial cell death assay
(1) Cell culture and passage: immortalized human oral epithelial cells hTERT-OME were purchased from Abmgood and cultured in MCDB151 medium (Sigma-Aldrich) containing 1% fetal bovine serum (volume fraction) (Hyclone product) at 25cm2In a culture flask. After the cells were grown to 80% confluency, the culture medium was discarded, washed once with PBS, and digested at 37 ℃ for 1 to 5 minutes by adding 0.5 to 1ml of 0.25% trypsin-0.53 mM EDTA digest (Sigma-Aldrich). After the cells were rounded, the digestion solution was discarded. Adding MCDB151 culture medium containing 10% fetal calf serum (volume fraction), blowing and resuspending cells, centrifuging for 5 minutes at 600g, discarding supernatant, resuspending cells in 15 ml of the MCDB151 culture medium containing 1% fetal calf serum, and passaging according to the ratio of 1: 3. Changing the culture medium every 2-3 days, and half-changing the culture medium, wherein the culture medium is changed into the new MCDB151 culture medium containing 1% fetal calf serum.
(2) hTERT-OME in logarithmic growth phase was seeded in 96-well plates at 8000 cells per well in a medium volume of 100. mu.l in serum-free MCDB151 medium. After 24 hours of cell adherent culture, the cell culture medium was changed to MCDB151 containing 2 mg/ml of total particulate matter in smoke, and simultaneously chrysanthemum extract was added to the culture medium to examine whether it could suppress cell death (0-1 mg/ml) caused by total particulate matter in smoke. The culture was continued for 24 hours.
(3) At the end of the cell culture, viable cells were detected using the MTS kit from Promega, and 10. mu.l of MTS solution was added to each cell culture well and incubated at 37 ℃ for 2 hours. Absorbance was measured at 490 nm for each well. In the experiment, a blank group (culture medium and MTS solution, no cell) and a control group (normal culture cell without tobacco juice and chrysanthemum extract, 0 mg/ml group in FIG. 1) were set simultaneously, and each group had three duplicate wells. The value of control minus blank was set at 100% (e.g.).
Cell viability = (OD490[ experimental group ] -OD490[ blank ])/(OD 490[ control group ] -OD490[ blank ]) × 100%;
(4) the survival ratio of cells after adding chrysanthemum extract to total particulate matter of extracted smoke of a certain product, Heatsticks (Feimu, available in hong Kong) is shown in FIG. 1, for example.
(5) The survival ratio of total particulate matter of smoke to cells after adding the chrysanthemum extract when making a cigarette which is not burned by heating is shown in fig. 2, for example. Wherein, the added cigarette is the product prepared in the step a-c, and the difference between the reference cigarette and the added cigarette is that the chrysanthemum extract is not added, and the rest is the same; the control group is normal cultured cells without tobacco juice or chrysanthemum extract.
And (4) conclusion: the cigarette added with the chrysanthemum extract can obviously reduce the oral risk and the death ratio of oral epithelial cells.
The foregoing shows and describes the general principles, essential features, and advantages of the invention. It will be understood by those skilled in the art that the present invention is not limited to the embodiments described above, which are described in the specification and illustrated only to illustrate the principle of the present invention, but that various changes and modifications may be made therein without departing from the spirit and scope of the present invention, which fall within the scope of the invention as claimed. The scope of the invention is defined by the appended claims and equivalents thereof.
Claims (10)
1. A heating cigarette added with chrysanthemum extract and capable of reducing oral risks is characterized by comprising the following components in parts by weight:
30-70 parts of tobacco raw materials, 10-30 parts of smoke agents, 10-50 parts of non-combustible inorganic fillers, 5-20 parts of adhesives, 1-20 parts of essences and spices and 5-20 parts of chrysanthemum extracts;
the tobacco raw material is reconstituted tobacco or a composition of the reconstituted tobacco and cut tobacco;
the preparation method of the chrysanthemum extract comprises the steps of crushing chrysanthemum, extracting for many times by using ultrapure water in a shaking way, combining extracting solutions, centrifuging at 4 ℃, taking supernate, freeze-drying the supernate and storing for later use to obtain the chrysanthemum extract.
2. The heated cigarette rod added with the chrysanthemum extract and capable of reducing oral risks according to claim 1, characterized in that the reconstituted tobacco is made of one or more of flue-cured tobacco, sun-cured tobacco and burley tobacco; the reconstituted tobacco is made of one or more of tobacco leaves, tobacco shreds and tobacco stems.
3. The heated cigarette rod added with the chrysanthemum extract and capable of reducing oral risks according to claim 1, characterized in that the reconstituted tobacco manufacturing method is a rolling method, a paper-making method or a thick pulp method.
4. The heated cigarette rod with reduced oral risk comprising the chrysanthemum extract according to claim 1, wherein the smoke agent is one or more of propylene glycol, glycerol, triethylene glycol, sorbitol, xylitol, and ethylene glycol.
5. The heated cigarette rod with reduced oral risk added with chrysanthemum extract according to claim 1, characterized in that the non-combustible inorganic filler is a mixture of one or more of calcium carbonate, magnesium oxide, magnesium sulfate, silica, chalk, perlite, diatomaceous earth.
6. The heated cigarette rod with reduced oral risk comprising the chrysanthemum extract according to claim 1, wherein the binder is an organic binder and/or a non-combustible inorganic binder.
7. The heated cigarette rod with reduced oral risk comprising the added chrysanthemum extract according to claim 6, wherein the organic binder is methyl cellulose, ethyl cellulose, carboxymethyl cellulose, acetyl cellulose, alginic acid binder, pectin binder or gelatin; the incombustible inorganic binder is potassium silicate or magnesium oxide.
8. the heated cigarette rod with reduced oral risk comprising the chrysanthemum extract according to claim 1, wherein the flavor and fragrance is a mixture of one or more of coffee extract, vanillin, megastigmatrienone, solanone, licorice, coffee, β -damascenone and tobacco extract.
9. The heated cigarette with the added chrysanthemum extract and the capability of reducing the oral risk according to claim 1, wherein the extraction frequency is 3 times, each time of ultrapure water shaking extraction is 20 minutes, and the dosage ratio of the chrysanthemum to each time of ultrapure water is as follows: 1000 g: 200 ml: 1000 ml: 500 ml; the centrifugation parameters were 13000g for 30 minutes; the freeze-drying temperature is-30 deg.C, and the freeze-drying time is 22 hr.
10. The use of the chrysanthemum extract according to claim 1 in the preparation of medicaments, health products and tobacco products for preventing and treating oral epithelial cell death caused by osmotic pressure.
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202010073782.7A CN111213909A (en) | 2020-01-22 | 2020-01-22 | A cigarette containing flos Chrysanthemi extract and capable of reducing oral risk |
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| Application Number | Priority Date | Filing Date | Title |
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| CN202010073782.7A CN111213909A (en) | 2020-01-22 | 2020-01-22 | A cigarette containing flos Chrysanthemi extract and capable of reducing oral risk |
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