CN111212607B - Medical plugging device - Google Patents
Medical plugging device Download PDFInfo
- Publication number
- CN111212607B CN111212607B CN201880061656.0A CN201880061656A CN111212607B CN 111212607 B CN111212607 B CN 111212607B CN 201880061656 A CN201880061656 A CN 201880061656A CN 111212607 B CN111212607 B CN 111212607B
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- Prior art keywords
- balloon
- occluder
- fluid
- occluder device
- tip element
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Classifications
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- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
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- Oral & Maxillofacial Surgery (AREA)
- Transplantation (AREA)
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- Surgical Instruments (AREA)
- Media Introduction/Drainage Providing Device (AREA)
Abstract
An occluder device (20) for occluding a cardiovascular defect or a gap between a medical device and adjacent body tissue, the occluder device comprising: a compliant balloon (5) defining a fluid-tight balloon cavity and provided with a balloon channel (7), said balloon channel (7) forming a longitudinal passageway from a proximal side (B2) to a distal side (B1) of said balloon; a tip element (10) disposed at the distal side of the balloon; a base element (4) arranged at the proximal side of the balloon; and a connection tool comprising at least one connection strut (9), said at least one connection strut (9) being attached to said tip element and to said base element, said tip element and said base element each having a guide opening (105 a, 105 b) substantially coaxial with said balloon channel (7) so as to slidingly receive a guide wire (106) for said device in said balloon channel; an elongate actuation means arranged to be longitudinally slidable in the balloon channel (7) and releasably connected to the tip element (10) and longitudinally slidable relative to the base element (4); a plurality of locking means (2, 13) for maintaining a predetermined distance between the tip element (10) and the base element (4); -a proximal connector means (1) for releasably connecting said occluder device (20) to a correspondingly configured distal connector means of a catheter device (107); the balloon (5) comprises a fluid port (19), the fluid port (19) being for filling a fluid into the balloon cavity and draining the fluid from the balloon cavity. An occluder system comprises an occluder device (20), and a catheter device (107) cooperating with the occluder device.
Description
Technical Field
The present invention relates generally to an occluder device for occluding a cardiovascular defect or a gap between a medical device and adjacent body tissue. In particular, the present invention relates to a paravalvular leak (paravalvular leak) occluder device. The plurality of devices of the present invention are intended to be implantable by means of percutaneous or minimally invasive interventions.
Background
There are various types of unnecessary or even pathological pathways in the body. If located in a blood vessel or heart, such access can result in a highly undesirable reduction of blood flow or bypass of blood flow around an organ.
WO 95/32018 discloses a method and apparatus for blocking a body passageway by inserting an expandable frame into the passageway and expanding the frame with an expandable balloon to locally embed the frame into walls of the passageway. The frame may be provided with a separate sealing membrane or the balloon may act as the sealing membrane. If the balloon is not used as the sealing membrane, the balloon may be removed with an inflation tube after the expanding step, or the balloon may be detached from the inflation tube and left in place as a sealing membrane or simply to lock the frame in place. By plastic deformation during the expanding step, the frame can be maintained in its expanded state. The expandable frame has a substantially cylindrical shape and is described as being suitable for use, for example, in closing an open arterial catheter, wherein an unwanted passageway or conduit connects the aorta to the main pulmonary artery adjacent the heart.
The US 4,836,204 describes a device for achieving the closure of a perforation in the diaphragm of the heart. The device comprises a double balloon diaphragmatic defect occlusion catheter to be inserted such that the two initially deflated balloons are positioned on opposite sides of the diaphragm. Once inflated, the plurality of balloons snugly fit the respective diaphragm wall sections, thereby avoiding leakage through the perforations.
Paravalvular leakage is a common complication that occurs in up to 30% of patients undergoing surgery or transcatheter prosthetic implantation. The option of transdermally treating these defects may provide a safer solution for high risk patients without exposing them to the risks associated with open heart re-surgery. However, the plurality of devices currently in use are sub-optimal because they have not been specifically developed for this intended use. Today, the sealing of paravalvular leaks is typically achieved with a number of devices originally designed to seal congenital heart defects. They are typically implanted in a low flow environment, such as patent foramen ovale or atrial diaphragmatic defects, and are implanted in a simple geometry. Conversely, paravalvular leaks develop under high pressure and flow conditions, and they are characterized by complex geometries. The defect is often crescent or oval shaped, which may comprise a tubular section with a plurality of deformations, and the structure is at most minimally compliant. In this environment, most of the plurality of currently available devices are limited by the poor adaptability of the device to the defect (lack of compliance) and by the lack of intra-device seals (due to the high flow environment).
Nevertheless, there are several concepts and embodiments of occlusion devices specifically designed for the closure of paravalvular leaks.
US 2014/0277426 A1 describes various devices for closing a gap between a medical device and adjacent body tissue. The plurality of devices typically includes a compliant body having a hollow interior, and the compliant body is provided with a fluid port intended to be supplied with a pressurized fluid in order to expand the compliant body. Various shapes and compositions of the compliant body, delivery means, and securing means are described.
U.S. Pat. No. 7,628,805 B2 generally discloses a number of concepts for locating and for repairing paravalvular leaks. The plurality of concepts include a plurality of seal holders, and a multi-component and radiation curable adhesive.
US 2012/078295 A1 discloses an occluder device for closing a passageway in a circulatory system. The device comprises an expandable fixation unit for fixing the occluder on the passageway by switching between a contracted form and an expanded form.
Despite the above, there remains a need for an improved occluder device which avoids the above-described drawbacks or a number of currently known devices.
Disclosure of Invention
The above and other objects are achieved by the present invention.
According to one aspect, there is provided an occluder device for occluding a cardiovascular defect or a gap between a medical device and adjacent body tissue, the occluder device comprising:
A compliant balloon defining a fluid-tight balloon lumen and provided with a balloon channel forming a longitudinal passageway from a proximal side to a distal side of the balloon;
A tip element disposed at the distal side of the balloon; a base member disposed at the proximal side of the balloon; and a connection tool comprising at least one connection strut attached to the tip element and the base element, the tip element and the base element each having a guide opening substantially coaxial with the balloon channel for slidingly receiving a guidewire for the device in the balloon channel;
An elongate actuation means arranged to be longitudinally slidable in the balloon channel and releasably connected to the tip element and longitudinally slidable relative to the base element;
a plurality of locking means for maintaining a predetermined distance between the tip element and the base element;
A proximal connector means for releasably connecting the occluder device to a correspondingly configured distal connector means of a catheter device;
The balloon includes a fluid port for filling a fluid into the balloon cavity and draining the fluid from the balloon cavity.
According to another aspect, there is provided an occluder system comprising: an occluder device as defined above, and a catheter device cooperating with the occluder device; the catheter device comprises: an implanted catheter tube connected to an operating handle, said implanted catheter tube comprising a longitudinal passageway for a guidewire; a distal connector means for releasably connecting said catheter device to said correspondingly configured proximal connector means of said occluder device; and a fluid transfer system releasably connected to a corresponding fluid port of the occluder device. The distal connector means and the proximal connector means are typically configured as a plurality of cooperating members provided at the distal end of the catheter device and the proximal end of the occluder device, respectively. Examples of such cooperating members include cooperating threads, bayonet (bajonet), or snap-fit connections.
A number of clinical indications include, but are not limited to, paravalvular leakage (PVL), patent Foramen Ovale (PFO), atrial diaphragmatic defect (ASD), ventricular diaphragmatic defect (VSD), intra-valvular leakage (IVL), intra-leaflet leakage, leaflet perforation, intravascular leakage of the first type after vascular grafting, and left atrial appendage occlusion.
The device is designed to be delivered in its compressed, i.e. longitudinally extended, manner into the area to be treated, and then the device will adapt to the anatomy of the landing zone using two mechanisms: inflation of the balloon, and shortening of the longitudinal dimension of the frame formed between the base element and the tip element. Under the influence of the internal pressure, the balloon will assume a certain volume, which means a certain transverse or radial dimension for a certain longitudinal frame size. The longitudinal frame dimension, which is changed by choosing a different distance between the tip element and the base element, will result in a corresponding change in radial extension. In other words, under otherwise constant conditions, shortening the distance between the tip element and the base element will result in a corresponding increase in radial extension.
In the context of the present disclosure, the terms "distal" and "proximal" are used accordingly in their standard meaning in the field of percutaneous cardiovascular devices. The term "proximal" refers to those components of the device components that are closer to the tip of a delivery catheter that is configured for manipulation by a user (e.g., by a surgeon's catheter handle) when following the delivery catheter during percutaneous delivery. The term "distal" is used to refer to those components of the device assembly that are farther from the end of the catheter that is configured for manipulation by a user and/or further insertion into a patient's body. Thus, in a device used in a gap between a medical device and adjacent body tissue, such as a paravalvular mitral valve leak, the proximal end may face the left atrium and the distal end may face the left ventricle when the device is deployed in the defect using a spaced-apart approach (TRANSSEPTAL APPROACH).
The term "compliant" as used in connection with a plurality of balloons or with a plurality of structural components should be understood to mean a deformability that substantially follows a force. Thus, a "compliant balloon" is understood to be a balloon that gradually expands under the influence of an increase in radial pressure so long as a certain burst pressure is not exceeded.
The connection tool includes at least one connection post attached to the tip element and the base element. The term "strut" is to be understood as an elongated structural element which may be formed, for example, as a thin wire, rod, rear wall tube, none of which necessarily have a circular cross section.
According to a further aspect, a method of sealing a cardiovascular defect or a gap between a medical device and adjacent body tissue by an occluder system as defined above comprises the steps of:
providing the occluder system with the occluder device connected to the catheter device;
positioning the occluder device in a compressed and longitudinally extending form in an area to be occluded;
inflating the balloon by filling a fluid into the balloon;
Expanding the balloon in a radial or lateral direction by shortening the distance between the tip element and the base element to the predetermined distance and locking the distance;
Releasing the occluder device from the catheter device.
Advantageous embodiments of the invention are defined in the dependent claims and/or described below.
The plurality of compliant balloons of the present invention need not be preformed. However, a plurality of preformed balloons may be used to establish a predetermined and non-uniform local elasticity against an applied radial pressure. Preferably, the balloon is made of a compliant material selected from Polycaprolactone (PCL), polyglycolic acid (PGA), polylactic acid (PLA) and polydioxanone (PDO or PDS). Most preferably, the compliant material is polycaprolactone.
Depending on the particular application, various configurations of the connection tool may be considered. According to an embodiment, the connection tool comprises a single connection strut, which is arranged inside the balloon channel or outside the balloon.
Advantageously, the connection means comprise a plurality of connection struts which are arranged in a cage-like manner outside the balloon. Applying internal pressure to the balloon will result in a spring force against the compliant balloon material and expansion of the balloon against the structural constraints provided by the plurality of external connection struts. In particular, such a configuration provides the advantage of an improved stability of the compliant balloon against unwanted local deformations. Typically, this will result in an improved adaptation of the occluder device to the geometry of the leak to be occluded.
The plurality of locking elements for maintaining a predetermined distance between the tip element and the base element may be configured in various ways. For example, they may comprise a rotatable actuation wire having a threaded portion formed to cooperate with a corresponding block formed in the distal disc. According to an advantageous embodiment, the plurality of locking means is configured as a ratchet mechanism, whereby the predetermined distance between the tip element and the base element is selectable from a range of distances. This allows an accurate and reliable definition of the radial extension of the occluder device and thus improves the reliability of the device.
The elongate actuation means is arranged to be longitudinally slidable in the balloon channel and is releasably connected to the tip element and is longitudinally slidable relative to the base element. For this purpose, the actuating means are formed as an elongated elastic member having a smooth surface. According to an advantageous embodiment, the elongated actuation means is configured as an actuation wire. The use of multiple actuation wires is well established in the field of cardiovascular interventions. In this context, a wire used with a plurality of suitable proximal counterparts (counterpiece) allows for a simple, accurate and reproducible selection of the distance between the tip element and the base element.
Tools for filling and discharging a plurality of balloons and other inflatable devices are also well known in the cardiovascular interventional arts. According to an advantageous embodiment, the balloon has a fluid port configured as an automatic shut-off valve when the fluid port is not connected to a corresponding fluid transfer system. In particular, this allows filling the balloon by a longitudinal fluid line which can then be disconnected and retracted, and which only needs to be reinserted and reconnected if a further filling or draining of the balloon is required.
The elements described above and those described and claimed hereinafter and used in accordance with the present invention should be construed generally as their meaning established in the medical field.
Drawings
The above-mentioned and other features and objects of this invention and the manner of attaining them will become more apparent and the invention itself will be better understood by reference to the following description of various embodiments of the invention taken in conjunction with the accompanying drawings.
FIG. 1a shows a cross-sectional view of an expanded occluding device including a connecting assembly within the balloon embodiment in accordance with an embodiment of the present invention;
FIGS. 1b and 1c show side elevation views of the device illustrated in FIG. 1 a;
FIG. 2a shows a cross-sectional view of an expanded occluding device including a plurality of connecting components outside of the balloon embodiment in accordance with an embodiment of the present invention;
FIGS. 2b and 2c show side elevation views of the device illustrated in FIG. 2 a;
FIG. 3a shows a cross-sectional view of an expanded occluding device including a coupling assembly outside of the balloon embodiment in accordance with an embodiment of the present invention;
FIGS. 3b and 3c show side elevation views of the device illustrated in FIG. 3 a;
FIG. 4a shows a cross-sectional view of an expanded occluding device including a ratchet longitudinal adjustment assembly within an embodiment of the balloon when deployed in a cardiovascular defect in accordance with an embodiment of the present invention;
FIGS. 4b and 4c show side elevation views of the device illustrated in FIG. 4 a;
FIG. 5a shows a cross-sectional view of the device illustrated in FIG. 4a after actuation and longitudinal shortening of the ratchet assembly;
FIGS. 5b and 5c show side elevation views of the device illustrated in FIG. 5 a;
FIG. 6 shows a side view of the device illustrated in FIG. 2a when connected to an implanted delivery system comprising a steerable catheter and a multi-knob delivery handle;
FIG. 7 shows a side view of the device illustrated in FIG. 2a as expanded in an congenital defect;
FIG. 8 shows a side view of the device illustrated in FIG. 2a when expanded in a cardiovascular defect, meaning a cavity or discontinuity in body tissue; and
Fig. 9 shows a side view of the device illustrated in fig. 2a when expanded in a gap between a medical device and adjacent body tissue.
It will be understood that the figures are not necessarily drawn to scale. In some examples, the plurality of opposing dimensions may be substantially deformed for ease of viewing.
Detailed Description
Fig. 1a shows a cross-sectional view of an expanded occluding device 20 including a connecting assembly within the balloon embodiment in accordance with an embodiment of the present invention. As shown, the device 20 comprises a compliant balloon 5 and a central cavity 6 and a frame formed by two plastic or metal deformable discs arranged at a distal end 10 and a proximal end 4 of the implant and connected by a strut 9, the strut 9 passing through the interior of the central cavity 6 of the balloon 5. The frame allows structural support to the balloon. The frame may be formed of a cutting structure such that each component of the frame is integrally connected to each other. The struts may have a linear or nonlinear section and may have deformable properties of multiple plastics or metals. The occluder forms a closed three-dimensional device. The embodiment includes a connecting element 1 of the device 20 for attachment to or release from an implanted catheter 14. An inflation port 3 into the balloon along or near a central axis is connected to the implanted catheter 14 and allows for inflation and deflation of the balloon 5 upon connection prior to release of the device 20. Within the central lumen 6 of the balloon may be a guidewire lumen 7 that allows a guidewire to move axially and freely through the device 20.
According to one embodiment of the present invention, the compliant balloon 5 may be inflated by any fluid composition including, but not limited to, saline solution, blood, foam, liquid polymer that may change its various properties to become rigid. This fluid will act as a long term shape-fixing, sealing and closing component of the chronic device 20. The balloon 5 serves as an acute shape-fixing, sealing and sealing component of the chronic device 20. The implanted catheter 14 and the inflation port 3 may contain a plurality of specific channels, valves and membranes designed to be compatible with the fluid under consideration, including a plurality of filtering membranes that are permeable to blood in the case where blood is used as the filling fluid for the balloon 5.
Also, the frame allows for longitudinal adjustment of the balloon 5 to enhance stability of the device 20 and closure of defects. A locking wire is threaded into a locking mechanism 1 within the central cavity 6 and connected to the distal disc 20. When an actuation wire is placed within the central lumen 6 and threaded into a locking mechanism 1 in the proximal end of the device 20 and connected to the distal disc 10, the locking mechanism is activated to secure the locking wire within its structure after a longitudinal change in the size of the device 20 by changing the distance between the two discs 10 and 4, and after the device 20 is released from the distal disc 10, thereby maintaining a fixed distance between the two discs 10 and 4. By a user directly pulling the actuation wire, in this example an axial movement of the actuation wire pulls the distal disc 10 in the direction of the proximal disc 4. Alternatively, the actuation wire may be rotated by the user, in this example engaged with a screw mechanism placed within the locking mechanism 1, such that rotation of the wire pulls the distal disc 10 in the direction of the proximal disc 4 and causes shortening of the device 20.
The plurality of discs 4, 10 may have a circular shape, an oval shape or a flower shape, an asymmetric shape or any other shape necessary or suitable for proper occlusion of cardiovascular defects and stability of the device.
In some embodiments, the frame may be designed with a limited confirmatory to create a tapered shape, providing the balloon 5 with an asymmetric restriction, e.g., narrowing at the distal end. The frame may have a generally conical or frustoconical shape, a cylindrical shape, or any other necessary or appropriate shape.
FIGS. 1b and 1c show side elevation views of the device 20 illustrated in FIG. 1 a.
Figures 2a to 5c further illustrate a number of optional features that may be provided in connection with the device 20 presented in the embodiment of figures 1a to 1 c. To avoid redundancy, only those features that differ from the above-described devices will be published. The same reference numerals indicate the same or corresponding features.
As further shown in fig. 2a, the frame may be formed by two deformable discs of plastic or metal at the proximal end 4 and distal end 10, which are connected by one or more struts 11 of any suitable form and extend externally and taper the balloon 5 assembly. Such an embodiment may allow for a cage-like structural constraint of the balloon 5 within its components to avoid unnecessary interference of the device with body tissue or implanted prosthesis and to provide anchoring support of the device 20 in the cardiovascular defect. In this embodiment of the invention, the frame may have 2, 4, 6, 8, 10, 12 or any suitable number of the struts.
In some embodiments of the invention, the plurality of struts 11 forming the frame may have different wall thicknesses and/or widths along their entire length or a section of the length. In this way, a strut 11 may have a first section wider than a second section. In other embodiments, a middle or a distal section of a strut 11 may be provided with a greater or lesser wall thickness and/or strut width. The change in wall thickness and/or the strut width may determine the radial stability of the frame.
Fig. 2b and 2c show side elevation views of the device 20 illustrated in fig. 2 a.
As illustrated in fig. 3a, the frame may be formed of two deformable discs of plastic or metal at the proximal end 4 and distal end 10, connected by a strut 12, extending externally and tapering the balloon 5 assembly.
Fig. 3b and 3c show side elevation views of the device 20 illustrated in fig. 3 a.
As further shown in fig. 4a, the longitudinal adjustment of the device 20 is achieved by having the locking wire designed as a ratchet mechanism 13 placed at the level of the proximal disc 4 and connected to the actuation wire. Since this mechanism allows the device 20 to be longitudinally adjusted in a manner that inhibits movement in other directions, the distal disc and the proximal disc can only be brought closer together before the device 20 is released from the implanted catheter 14, as shown in fig. 5 a.
Fig. 4b and 4c show side elevation views of the device 20 illustrated in fig. 4 a.
Fig. 5b and 5c show side elevation views of the device 20 illustrated in fig. 5a, which are equivalent to the fig. 4a after actuation and longitudinal shortening of the ratchet assembly.
Fig. 6 depicts a perspective view of the device 20 illustrated in fig. 2a and its various major components when connected to the implanted catheter 14, which includes a multi-knob carrying handle 18.
The implanted catheter 14 allows the device 20 to be introduced through a cardiovascular system into a defect in a cardiovascular device for deploying chronic implants 20 to seal the defect and maintain the occlusion.
The implanted catheter 14 is connected to the device 20 by a connecting element 1. It includes the device 20 in its contracted rather than expanded form within its steerable catheter, as well as all components and passageways, to allow controlled exposure, inflation, deflation, longitudinal adjustment of the restorability of the device 20, and release at the end of the implantation.
The exposure of the device 20 is controlled by the implanted knob 16 in the delivery system handle 18.
It allows the routing of the guide wire (coarse) for guiding the device 20 to the target defect and the routing of the actuation wire for adjusting the length of the device 20 within its structure and within the central lumen 6 of the device 20.
It includes the plurality of mechanisms that inflate and deflate the implant from the inflation port 19 of the balloon 5 in the handle 18.
It features a steerable feature to achieve good positioning of the occluding device 20 in the heart defect under control of the steering knob 15, the steering knob 15 including a steering limiter within the delivery system handle 18. The steerable performance would allow for an antegrade approach from the venous groin to the inferior vena cava, to the right atrium, to the left atrium, or retrograde from the arterial groin to the left ventricle, and would allow the device 20 to be implanted by any technique known in the art.
In another configuration, the implanted catheter 14 is resilient rather than steerable. The balloon 5 implant is a fully compliant balloon implant, wherein the balloon v changes the percentage in radial and longitudinal shape when the pressure and/or volume of fluid in the balloon 5 increases above the pressure and/or volume required by the balloon to reach the minimum target shape.
The balloon 5 may be made of any suitable biocompatible material including Polycaprolactone (PCL), polyglycolic acid (PGA), polylactic acid (PLA), and polydioxanone (PDO or PDS).
The frame comprises the distal 10 and proximal 4 discs and the plurality of stents 9, 11, 12 within the balloon 5 embodiment, and has a plurality of plastic or metal deformable properties, and may be made of any suitable other biocompatible material including stainless steel, titanium, nitinol, tantalum, gold, platinum iridium, tungsten, alloys of any of the foregoing, including platinum iridium alloys, cobalt chromium alloys, nickel titanium alloys, and nickel titanium platinum alloys. Alternatively, the frame may be made of polymers including polyesters and polycarbonate copolymers, as well as any metal or polymer capable of deforming soft plastics, or a combination of polymer(s) and metal(s). Suitable materials include biodegradable materials that are also biocompatible, meaning a material that undergoes cleavage or decomposition into non-essential compounds as part of a normal biological process. A variety of suitable biodegradable materials include polylactic acid, polyglycolic acid (PGA), collagen or other connective or natural materials, polycaprolactone, hyaluronic acid, adhesion proteins, copolymers of these materials, and composites and combinations thereof, as well as combinations of other biodegradable materials.
The frame and the balloon of the device 20 according to the invention may be manufactured in different sizes, according to the necessary or appropriate use in cardiovascular defects of different sizes or other suitable areas of the body.
In the initial configuration of the device 20 and the implanted catheter 14, to allow for introduction of the device into the patient, the device 20 is pre-installed without expanding within the implanted catheter 14 and the entire assembly has been sterilized.
List of reference numerals
1 Connection
2 Locking mechanism
3 Air charging port
4 Proximal disc
5 Saccule
6 Folding saccule cavity
7 Seal wire cavity
8 Locking wire
9 Single internal strut
10 Distal disc
11 Multiple outer struts
12 Single outer strut
13 Ratchet mechanism
14 Implanted catheter
15 Steering knob
16 Implanted advance and release knob
17-Disc actuating knob
18 Conveyor system handle
19 Balloon inflation port
20 Plugging device
105A distal guide opening
105B proximal guide opening
106 Guide wire
107 Catheter device
Claims (10)
1. An occluder device (20) for occluding a cardiovascular defect or a gap between a medical device and adjacent body tissue, characterized by: the occluder device comprises a ratio of
A compliant balloon (5) defining a fluid-tight balloon cavity and being provided with a balloon channel (7), said balloon channel (7) forming a longitudinal passageway from a proximal side (B2) to a distal side (B1) of said balloon (5), said balloon (5) comprising a fluid port (3), said fluid port (3) for filling a fluid into said balloon cavity and draining said fluid from said balloon cavity;
A tip element (10) arranged at the distal side of the balloon (5); -a base (4) arranged at the proximal side of the balloon (5); and a connecting means comprising a plurality of connecting struts arranged in a cage-like manner outside the balloon (5) and connected to the tip element and the base, and a single internal connecting strut (9), the internal connecting struts (9) being arranged within the balloon channel (7), the tip element and the base each having a guide opening (105 a, 105 b) coaxial with the balloon channel (7) for slidingly receiving a guide wire (106) for the device therein;
an elongate actuator arranged to be longitudinally slidable in the balloon channel (7) and releasably connected to the tip element (10) and longitudinally slidable relative to the base (4);
A plurality of locking means (2, 13) for maintaining a predetermined distance between the tip element (10) and the base (4); and
A proximal connector means (1) for releasably connecting the occluder device (20) to a correspondingly configured distal connector means of a catheter device (107).
2. The occluder device of claim 1, wherein: the compliant balloon (5) is made of a compliant material selected from the group consisting of polycaprolactone, polyglycolic acid, polylactic acid, and polydioxanone.
3. The occluder device of claim 1 or 2, wherein: the plurality of locking means is configured as a ratchet mechanism whereby the predetermined distance between the tip element (10) and the base (4) is selectable from a range of distances.
4. The occluder device of claim 1 or 2, wherein: the elongate actuator is configured as an actuation wire.
5. The occluder device of claim 1 or 2, wherein: the fluid port (3) is configured as an automatic shut-off valve when the fluid port is not connected to a corresponding fluid transfer system (19).
6. The occluder device of claim 1, wherein: the base (4) comprises a disc.
7. The occluder device of claim 6, wherein: the disc is deformable.
8. The occluder device of claim 1, wherein: the balloon (5) is shaped such that the distal side (B1) and the proximal side (B2) of the balloon (5) have a tapered shape when the balloon cavity is filled with the fluid.
9. The occluder device of claim 1, wherein: the fluid port (3) is provided on an outer surface of the balloon (5) for filling and draining the fluid into and from the balloon cavity.
10. An occluder system, characterized in that: the occluder system comprises: the occluder device (20) of claim 1, and a catheter device (107) cooperating with the occluder device; the catheter device includes: an implanted catheter tube (14) connected to an operating handle, said implanted catheter tube (14) comprising a longitudinal passageway for a guidewire (106); a distal connector means for releasably connecting the catheter device (107) to the correspondingly configured proximal connector means (1) of the occluder device (20); and a fluid transfer system (19) releasably connected to the fluid port (3) of the occluder device (20).
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EP17192792.4 | 2017-09-23 | ||
PCT/EP2018/075716 WO2019057950A1 (en) | 2017-09-23 | 2018-09-23 | Medical occluder device |
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CN111212607B true CN111212607B (en) | 2024-05-31 |
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CN201980072797.7A Pending CN112955079A (en) | 2017-09-23 | 2019-03-26 | Medical occlusion device |
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Families Citing this family (13)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP3459469A1 (en) | 2017-09-23 | 2019-03-27 | Universität Zürich | Medical occluder device |
US11944315B2 (en) | 2019-09-26 | 2024-04-02 | Universität Zürich | Left atrial appendage occlusion devices |
EP3815627B1 (en) * | 2019-10-31 | 2022-03-16 | Peter Osypka Stiftung | Device for adapting an laa occluder after implantation |
WO2021191833A1 (en) | 2020-03-25 | 2021-09-30 | Universitat Zurich | Medical occluder delivery systems |
US11883014B2 (en) | 2020-05-21 | 2024-01-30 | St. Jude Medical, Cardiology Division, Inc. | Biomaterial occluder delivery mechanism |
CN111803780B (en) * | 2020-06-29 | 2022-02-11 | 中国人民解放军陆军军医大学第一附属医院 | Tunnel type sacculus |
WO2022051215A1 (en) * | 2020-09-01 | 2022-03-10 | Venacore Inc. | Longitudinally compressible vascular occluder |
CN112022246B (en) | 2020-11-06 | 2021-02-26 | 上海介入医疗器械有限公司 | Left auricle occluder and use method thereof |
CN115462844A (en) * | 2021-06-10 | 2022-12-13 | 微创投资控股有限公司 | Plugging device for perforation of ventricular septum and treatment system |
CN115462845A (en) * | 2021-06-10 | 2022-12-13 | 微创投资控股有限公司 | Plugging device for perforation of ventricular septum and treatment system |
CN216603785U (en) * | 2021-09-24 | 2022-05-27 | 安徽通灵仿生科技有限公司 | Interim left heart auxiliary device of intervention formula |
CN115105142A (en) * | 2022-06-30 | 2022-09-27 | 宁波迪创医疗科技有限公司 | Left auricle filling instrument |
CN117814958B (en) * | 2024-02-26 | 2024-06-18 | 杭州德晋医疗科技有限公司 | Atrioventricular valve clamping device |
Citations (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3834394A (en) * | 1969-11-21 | 1974-09-10 | R Sessions | Occlusion device and method and apparatus for inserting the same |
US5853422A (en) * | 1996-03-22 | 1998-12-29 | Scimed Life Systems, Inc. | Apparatus and method for closing a septal defect |
US6273907B1 (en) * | 1997-04-07 | 2001-08-14 | Broncus Technologies, Inc. | Bronchial stenter |
WO2003039624A2 (en) * | 2001-11-06 | 2003-05-15 | Possis Medical Inc. | Guidewire occlusion system utilizing repeatably inflatable gas-filled occlusive device |
WO2005092204A2 (en) * | 2004-03-22 | 2005-10-06 | Accessclosure, Inc. | Apparatus for sealing a vascular puncture |
CN104905890A (en) * | 2014-03-14 | 2015-09-16 | 徐州亚太科技有限公司 | Novel degradable stopper implanted through guide pipe and conveying system of novel degradable stopper |
CN105120798A (en) * | 2012-11-27 | 2015-12-02 | 康特戈医疗有限责任公司 | Percutaneous transluminal angioplasty device with integral embolic filter |
CN204971415U (en) * | 2015-06-01 | 2016-01-20 | 武功县人民医院 | Plugging device of transsphenoidal approach pituitary adenoma postsurgical sphenoid sinus |
WO2016149653A2 (en) * | 2015-03-19 | 2016-09-22 | Prytime Medical Devices, Inc. | System and method for low-profile occlusion balloon catheter |
CN106344082A (en) * | 2016-09-28 | 2017-01-25 | 宁波迪创医疗科技有限公司 | Volume reduction device for left ventricle |
Family Cites Families (410)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5104399A (en) | 1986-12-10 | 1992-04-14 | Endovascular Technologies, Inc. | Artificial graft and implantation method |
US4686962A (en) | 1986-07-03 | 1987-08-18 | Habley Medical Technology Corporation | Disposable cartridge assembly for hypodermically implanting a genitourinary prosthesis |
US4802479A (en) | 1986-10-31 | 1989-02-07 | C. R. Bard, Inc. | Hand-held instrument for implanting, dispensing, and inflating an inflatable membrane |
US4836204A (en) | 1987-07-06 | 1989-06-06 | Landymore Roderick W | Method for effecting closure of a perforation in the septum of the heart |
US5795325A (en) * | 1991-07-16 | 1998-08-18 | Heartport, Inc. | Methods and apparatus for anchoring an occluding member |
US5304123A (en) | 1991-10-24 | 1994-04-19 | Children's Medical Center Corporation | Detachable balloon catheter for endoscopic treatment of vesicoureteral reflux |
US6161543A (en) | 1993-02-22 | 2000-12-19 | Epicor, Inc. | Methods of epicardial ablation for creating a lesion around the pulmonary veins |
US5499995C1 (en) * | 1994-05-25 | 2002-03-12 | Paul S Teirstein | Body passageway closure apparatus and method of use |
US6440097B1 (en) | 1995-10-06 | 2002-08-27 | Target Therapeutics, Inc. | Balloon catheter with delivery side holes |
US20050245894A1 (en) | 1996-05-20 | 2005-11-03 | Medtronic Vascular, Inc. | Methods and apparatuses for drug delivery to an intravascular occlusion |
US5830228A (en) | 1996-05-29 | 1998-11-03 | Urosurge, Inc. | Methods and systems for deployment of a detachable balloon at a target site in vivo |
WO1998007375A1 (en) | 1996-08-22 | 1998-02-26 | The Trustees Of Columbia University | Endovascular flexible stapling device |
US6311692B1 (en) | 1996-10-22 | 2001-11-06 | Epicor, Inc. | Apparatus and method for diagnosis and therapy of electrophysiological disease |
US6237605B1 (en) | 1996-10-22 | 2001-05-29 | Epicor, Inc. | Methods of epicardial ablation |
US7052493B2 (en) | 1996-10-22 | 2006-05-30 | Epicor Medical, Inc. | Methods and devices for ablation |
US6174322B1 (en) | 1997-08-08 | 2001-01-16 | Cardia, Inc. | Occlusion device for the closure of a physical anomaly such as a vascular aperture or an aperture in a septum |
US6183492B1 (en) * | 1997-08-28 | 2001-02-06 | Charles C. Hart | Perfusion-isolation catheter apparatus and method |
US6476069B2 (en) | 1997-09-11 | 2002-11-05 | Provasis Therapeutics Inc. | Compositions for creating embolic agents and uses thereof |
US8257725B2 (en) | 1997-09-26 | 2012-09-04 | Abbott Laboratories | Delivery of highly lipophilic agents via medical devices |
EP1023004A4 (en) | 1997-10-10 | 2003-03-26 | John D Corbitt | Breast implant |
US8709007B2 (en) | 1997-10-15 | 2014-04-29 | St. Jude Medical, Atrial Fibrillation Division, Inc. | Devices and methods for ablating cardiac tissue |
US6267747B1 (en) | 1998-05-11 | 2001-07-31 | Cardeon Corporation | Aortic catheter with porous aortic root balloon and methods for inducing cardioplegic arrest |
US6241678B1 (en) | 1998-08-21 | 2001-06-05 | Aga Medical Corporation | Sizing catheter for measuring septal defects |
US8257724B2 (en) | 1998-09-24 | 2012-09-04 | Abbott Laboratories | Delivery of highly lipophilic agents via medical devices |
US7713282B2 (en) | 1998-11-06 | 2010-05-11 | Atritech, Inc. | Detachable atrial appendage occlusion balloon |
US7044134B2 (en) | 1999-11-08 | 2006-05-16 | Ev3 Sunnyvale, Inc | Method of implanting a device in the left atrial appendage |
US7128073B1 (en) | 1998-11-06 | 2006-10-31 | Ev3 Endovascular, Inc. | Method and device for left atrial appendage occlusion |
US6488689B1 (en) | 1999-05-20 | 2002-12-03 | Aaron V. Kaplan | Methods and apparatus for transpericardial left atrial appendage closure |
EP1207788A4 (en) | 1999-07-19 | 2009-12-09 | St Jude Medical Atrial Fibrill | Apparatus and method for ablating tissue |
US6231561B1 (en) | 1999-09-20 | 2001-05-15 | Appriva Medical, Inc. | Method and apparatus for closing a body lumen |
US6652555B1 (en) | 1999-10-27 | 2003-11-25 | Atritech, Inc. | Barrier device for covering the ostium of left atrial appendage |
US6689150B1 (en) | 1999-10-27 | 2004-02-10 | Atritech, Inc. | Filter apparatus for ostium of left atrial appendage |
US6551303B1 (en) | 1999-10-27 | 2003-04-22 | Atritech, Inc. | Barrier device for ostium of left atrial appendage |
US6994092B2 (en) | 1999-11-08 | 2006-02-07 | Ev3 Sunnyvale, Inc. | Device for containing embolic material in the LAA having a plurality of tissue retention structures |
US7483743B2 (en) | 2000-01-11 | 2009-01-27 | Cedars-Sinai Medical Center | System for detecting, diagnosing, and treating cardiovascular disease |
US6926712B2 (en) | 2000-03-24 | 2005-08-09 | Boston Scientific Scimed, Inc. | Clamp having at least one malleable clamp member and surgical method employing the same |
US6692491B1 (en) | 2000-03-24 | 2004-02-17 | Scimed Life Systems, Inc. | Surgical methods and apparatus for positioning a diagnostic or therapeutic element around one or more pulmonary veins or other body structures |
US6468301B1 (en) | 2000-03-27 | 2002-10-22 | Aga Medical Corporation | Repositionable and recapturable vascular stent/graft |
US6468303B1 (en) | 2000-03-27 | 2002-10-22 | Aga Medical Corporation | Retrievable self expanding shunt |
US6964669B1 (en) | 2000-04-12 | 2005-11-15 | Ams Research Corporation | Linear delivery system for deployment of a detachable balloon at a target site in vivo |
US7056294B2 (en) | 2000-04-13 | 2006-06-06 | Ev3 Sunnyvale, Inc | Method and apparatus for accessing the left atrial appendage |
US6334864B1 (en) | 2000-05-17 | 2002-01-01 | Aga Medical Corp. | Alignment member for delivering a non-symmetric device with a predefined orientation |
AU2001285078A1 (en) | 2000-08-18 | 2002-03-04 | Atritech, Inc. | Expandable implant devices for filtering blood flow from atrial appendages |
DE60044569D1 (en) | 2000-08-29 | 2010-07-29 | Kaplan | METHOD AND DEVICE FOR THE TRANSPERICARDIAL CLOSURE OF THE LEFT HEART EYE |
US6942661B2 (en) | 2000-08-30 | 2005-09-13 | Boston Scientific Scimed, Inc. | Fluid cooled apparatus for supporting diagnostic and therapeutic elements in contact with tissue |
EP1318766A2 (en) | 2000-09-21 | 2003-06-18 | Atritech, Inc. | Apparatus for implanting devices in atrial appendages |
ATE434418T1 (en) | 2001-02-16 | 2009-07-15 | Cordis Corp | METHOD FOR PRODUCING A BALLOON CATHETER STENT APPLICATION SYSTEM WITH GROOVES |
US6656488B2 (en) | 2001-04-11 | 2003-12-02 | Ethicon Endo-Surgery, Inc. | Bioabsorbable bag containing bioabsorbable materials of different bioabsorption rates for tissue engineering |
US7604612B2 (en) | 2001-05-01 | 2009-10-20 | St. Jude Medical, Cardiology Division, Inc. | Emboli protection devices and related methods of use |
US7374560B2 (en) | 2001-05-01 | 2008-05-20 | St. Jude Medical, Cardiology Division, Inc. | Emboli protection devices and related methods of use |
US7422579B2 (en) | 2001-05-01 | 2008-09-09 | St. Jude Medical Cardiology Divison, Inc. | Emboli protection devices and related methods of use |
US6537300B2 (en) | 2001-05-30 | 2003-03-25 | Scimed Life Systems, Inc. | Implantable obstruction device for septal defects |
US7338514B2 (en) | 2001-06-01 | 2008-03-04 | St. Jude Medical, Cardiology Division, Inc. | Closure devices, related delivery methods and tools, and related methods of use |
EP1392394A4 (en) | 2001-06-04 | 2005-05-18 | Albert Einstein Healthcare Network | Cardiac stimulating apparatus having a blood clot filter and atrial pacer |
US20030045859A1 (en) | 2001-06-11 | 2003-03-06 | Larry Dominguez | Delivery system using balloon catheter |
US7011671B2 (en) | 2001-07-18 | 2006-03-14 | Atritech, Inc. | Cardiac implant device tether system and method |
US7097665B2 (en) | 2003-01-16 | 2006-08-29 | Synecor, Llc | Positioning tools and methods for implanting medical devices |
US10098640B2 (en) | 2001-12-04 | 2018-10-16 | Atricure, Inc. | Left atrial appendage devices and methods |
US7749157B2 (en) | 2001-12-04 | 2010-07-06 | Estech, Inc. (Endoscopic Technologies, Inc.) | Methods and devices for minimally invasive cardiac surgery for atrial fibrillation |
US20030181942A1 (en) | 2002-01-25 | 2003-09-25 | Sutton Gregg S. | Atrial appendage blood filtration systems |
US6932816B2 (en) | 2002-02-19 | 2005-08-23 | Boston Scientific Scimed, Inc. | Apparatus for converting a clamp into an electrophysiology device |
US6638257B2 (en) | 2002-03-01 | 2003-10-28 | Aga Medical Corporation | Intravascular flow restrictor |
US7052511B2 (en) | 2002-04-04 | 2006-05-30 | Scimed Life Systems, Inc. | Delivery system and method for deployment of foreshortening endoluminal devices |
US7976564B2 (en) | 2002-05-06 | 2011-07-12 | St. Jude Medical, Cardiology Division, Inc. | PFO closure devices and related methods of use |
US20040098042A1 (en) | 2002-06-03 | 2004-05-20 | Devellian Carol A. | Device with biological tissue scaffold for percutaneous closure of an intracardiac defect and methods thereof |
DE60336914D1 (en) | 2002-08-24 | 2011-06-09 | Atrial Fibrillation Division Inc | METHOD AND DEVICE FOR LOCATING THE FOSSA OVALIS AND PERFORMING A TRANSSEPTAL PUNCTURE |
US8758372B2 (en) | 2002-08-29 | 2014-06-24 | St. Jude Medical, Cardiology Division, Inc. | Implantable devices for controlling the size and shape of an anatomical structure or lumen |
US7455690B2 (en) | 2002-08-29 | 2008-11-25 | Mitralsolutions, Inc. | Methods for controlling the internal circumference of an anatomic orifice or lumen |
US7488337B2 (en) * | 2002-09-30 | 2009-02-10 | Saab Mark A | Apparatus and methods for bone, tissue and duct dilatation |
US7615010B1 (en) | 2002-10-03 | 2009-11-10 | Integrated Sensing Systems, Inc. | System for monitoring the physiologic parameters of patients with congestive heart failure |
US7211048B1 (en) | 2002-10-07 | 2007-05-01 | Integrated Sensing Systems, Inc. | System for monitoring conduit obstruction |
US20040254594A1 (en) * | 2003-01-24 | 2004-12-16 | Arthur Alfaro | Cardiac defect occlusion device |
US7293562B2 (en) | 2003-03-27 | 2007-11-13 | Cierra, Inc. | Energy based devices and methods for treatment of anatomic tissue defects |
US20040267306A1 (en) | 2003-04-11 | 2004-12-30 | Velocimed, L.L.C. | Closure devices, related delivery methods, and related methods of use |
US8372112B2 (en) | 2003-04-11 | 2013-02-12 | St. Jude Medical, Cardiology Division, Inc. | Closure devices, related delivery methods, and related methods of use |
US20040267348A1 (en) | 2003-04-11 | 2004-12-30 | Gunderson Richard C. | Medical device delivery systems |
US7473271B2 (en) | 2003-04-11 | 2009-01-06 | Boston Scientific Scimed, Inc. | Stent delivery system with securement and deployment accuracy |
US7597704B2 (en) | 2003-04-28 | 2009-10-06 | Atritech, Inc. | Left atrial appendage occlusion device with active expansion |
US7470282B2 (en) | 2003-06-30 | 2008-12-30 | Boston Scientific Scimed, Inc. | Stent grip and system for use therewith |
US9498366B2 (en) * | 2003-07-28 | 2016-11-22 | Baronova, Inc. | Devices and methods for pyloric anchoring |
US7735493B2 (en) | 2003-08-15 | 2010-06-15 | Atritech, Inc. | System and method for delivering a left atrial appendage containment device |
DE10338702B9 (en) | 2003-08-22 | 2007-04-26 | Occlutech Gmbh | Occlusioninstrument |
ATE375754T1 (en) | 2003-09-12 | 2007-11-15 | Nmt Medical Inc | DEVICE FOR PREVENTING THROMB FORMATION IN THE LEFT ATRIAL APPENDIX |
US8114123B2 (en) | 2003-09-19 | 2012-02-14 | St. Jude Medical, Inc. | Apparatus and methods for tissue gathering and securing |
US9579194B2 (en) | 2003-10-06 | 2017-02-28 | Medtronic ATS Medical, Inc. | Anchoring structure with concave landing zone |
ES2700851T3 (en) | 2003-10-09 | 2019-02-19 | Sentreheart Inc | Apparatus for tissue binding |
SE526861C2 (en) | 2003-11-17 | 2005-11-15 | Syntach Ag | Tissue lesion creation device and a set of devices for the treatment of cardiac arrhythmia disorders |
EP3345577A1 (en) | 2003-12-04 | 2018-07-11 | Boston Scientific Scimed, Inc. | System for delivering a left atrail appendange containment device |
US9039724B2 (en) | 2004-03-19 | 2015-05-26 | Aga Medical Corporation | Device for occluding vascular defects |
US8747453B2 (en) | 2008-02-18 | 2014-06-10 | Aga Medical Corporation | Stent/stent graft for reinforcement of vascular abnormalities and associated method |
US8777974B2 (en) | 2004-03-19 | 2014-07-15 | Aga Medical Corporation | Multi-layer braided structures for occluding vascular defects |
US8398670B2 (en) | 2004-03-19 | 2013-03-19 | Aga Medical Corporation | Multi-layer braided structures for occluding vascular defects and for occluding fluid flow through portions of the vasculature of the body |
US8313505B2 (en) | 2004-03-19 | 2012-11-20 | Aga Medical Corporation | Device for occluding vascular defects |
US7727228B2 (en) | 2004-03-23 | 2010-06-01 | Medtronic Cryocath Lp | Method and apparatus for inflating and deflating balloon catheters |
CN101146570B (en) | 2004-04-08 | 2010-10-06 | Aga医药有限公司 | Flanged occlusion devices and methods |
US8801746B1 (en) | 2004-05-04 | 2014-08-12 | Covidien Lp | System and method for delivering a left atrial appendage containment device |
US7842069B2 (en) * | 2004-05-07 | 2010-11-30 | Nmt Medical, Inc. | Inflatable occluder |
US8663245B2 (en) | 2004-06-18 | 2014-03-04 | Medtronic, Inc. | Device for occlusion of a left atrial appendage |
US8409219B2 (en) | 2004-06-18 | 2013-04-02 | Medtronic, Inc. | Method and system for placement of electrical lead inside heart |
US7367975B2 (en) | 2004-06-21 | 2008-05-06 | Cierra, Inc. | Energy based devices and methods for treatment of anatomic tissue defects |
US7276078B2 (en) | 2004-06-30 | 2007-10-02 | Edwards Lifesciences Pvt | Paravalvular leak detection, sealing, and prevention |
US7549988B2 (en) | 2004-08-30 | 2009-06-23 | Boston Scientific Scimed, Inc. | Hybrid lesion formation apparatus, systems and methods |
US9713730B2 (en) | 2004-09-10 | 2017-07-25 | Boston Scientific Scimed, Inc. | Apparatus and method for treatment of in-stent restenosis |
US7927346B2 (en) | 2004-09-10 | 2011-04-19 | Stryker Corporation | Diversion device to increase cerebral blood flow |
US20100312129A1 (en) | 2005-01-26 | 2010-12-09 | Schecter Stuart O | Cardiovascular haptic handle system |
US8366743B2 (en) | 2005-01-28 | 2013-02-05 | Lifetech Scientific (Shenzhen) Co., Ltd | Heart septal defect occlusion device |
CN100389732C (en) | 2005-01-28 | 2008-05-28 | 先健科技(深圳)有限公司 | Heart septal defect stopper with self regulating function |
US7892228B2 (en) | 2005-02-25 | 2011-02-22 | Boston Scientific Scimed, Inc. | Dual mode lesion formation apparatus, systems and methods |
US7320665B2 (en) | 2005-03-02 | 2008-01-22 | Venkataramana Vijay | Cardiac Ventricular Geometry Restoration Device and Treatment for Heart Failure |
JP5271697B2 (en) | 2005-03-23 | 2013-08-21 | アボット ラボラトリーズ | Delivery of highly lipophilic drugs through medical devices |
AU2006230162B2 (en) | 2005-03-25 | 2011-09-29 | St. Jude Medical, Cardiology Division, Inc. | Methods and apparatus for controlling the internal circumference of an anatomic orifice or lumen |
US8864823B2 (en) | 2005-03-25 | 2014-10-21 | StJude Medical, Cardiology Division, Inc. | Methods and apparatus for controlling the internal circumference of an anatomic orifice or lumen |
WO2006110734A2 (en) | 2005-04-07 | 2006-10-19 | Sentreheart, Inc. | Apparatus and method for the ligation of tissue |
AU2006240365B2 (en) | 2005-04-22 | 2011-08-25 | Rex Medical, L.P. | Closure device for left atrial appendage |
US7740627B2 (en) | 2005-04-29 | 2010-06-22 | Medtronic Cryocath Lp | Surgical method and apparatus for treating atrial fibrillation |
ATE442101T1 (en) | 2005-05-17 | 2009-09-15 | Syntach Ag | DEVICE AND KIT FOR TREATING DISORDERS OF THE CARDIAC RHYTHM REGULATION SYSTEM |
US8221348B2 (en) | 2005-07-07 | 2012-07-17 | St. Jude Medical, Cardiology Division, Inc. | Embolic protection device and methods of use |
US7824397B2 (en) | 2005-08-19 | 2010-11-02 | Boston Scientific Scimed, Inc. | Occlusion apparatus |
US7837619B2 (en) | 2005-08-19 | 2010-11-23 | Boston Scientific Scimed, Inc. | Transeptal apparatus, system, and method |
US7998095B2 (en) | 2005-08-19 | 2011-08-16 | Boston Scientific Scimed, Inc. | Occlusion device |
US7972359B2 (en) | 2005-09-16 | 2011-07-05 | Atritech, Inc. | Intracardiac cage and method of delivering same |
EP1948030B1 (en) | 2005-11-11 | 2010-07-21 | Occlutech GmbH | Occlusion instrument for closing a cardiac auricle |
US8100938B2 (en) | 2005-11-14 | 2012-01-24 | Occlutech Holding Ag | Occlusion device for occluding an atrial auricula and method for producing same |
US20070135826A1 (en) | 2005-12-01 | 2007-06-14 | Steve Zaver | Method and apparatus for delivering an implant without bias to a left atrial appendage |
US8142470B2 (en) | 2005-12-01 | 2012-03-27 | Atritech, Inc. | Method for accessing the left atrial appendage with a balloon-tipped transeptal sheath |
US8052715B2 (en) | 2005-12-01 | 2011-11-08 | Atritech, Inc. | Method and apparatus for recapturing an implant from the left atrial appendage |
US9034006B2 (en) | 2005-12-01 | 2015-05-19 | Atritech, Inc. | Method and apparatus for retrieving an embolized implant |
US8758294B2 (en) | 2005-12-27 | 2014-06-24 | Acist Medical Systems, Inc. | Balloon inflation device |
TWI428111B (en) * | 2006-01-13 | 2014-03-01 | Olympus Medical Systems Corp | Retainer for medical use |
US8900287B2 (en) | 2006-01-13 | 2014-12-02 | Aga Medical Corporation | Intravascular deliverable stent for reinforcement of abdominal aortic aneurysm |
US8778008B2 (en) | 2006-01-13 | 2014-07-15 | Aga Medical Corporation | Intravascular deliverable stent for reinforcement of vascular abnormalities |
US8043258B2 (en) | 2006-01-24 | 2011-10-25 | Boston Scientific Scimed, Inc. | Flow-inflated diffusion therapeutic delivery |
US8162974B2 (en) | 2006-02-02 | 2012-04-24 | Boston Scientific Scimed, Inc. | Occlusion apparatus, system, and method |
US8221405B2 (en) | 2006-02-06 | 2012-07-17 | Coherex Medical, Inc. | Patent foramen ovale closure device and methods for determining RF dose for patent foramen ovale closure |
AU2007212501B2 (en) | 2006-02-07 | 2011-03-31 | Tepha, Inc. | Polymeric, degradable drug-eluting stents and coatings |
US20070225756A1 (en) | 2006-03-22 | 2007-09-27 | Radi Medical Systems Ab | Closure device and insertion assembly |
DE102006013770A1 (en) | 2006-03-24 | 2007-09-27 | Occlutech Gmbh | Occlusion instrument and method for its production |
US7846175B2 (en) | 2006-04-03 | 2010-12-07 | Medrad, Inc. | Guidewire and collapsable filter system |
ATE524114T1 (en) | 2006-04-07 | 2011-09-15 | Lifetech Scient Shenzhen Co | SELF-ADAPTABLE CLOSURE DEVICE FOR TREATING CONGENITAL HEART DISEASE |
US8652201B2 (en) | 2006-04-26 | 2014-02-18 | The Cleveland Clinic Foundation | Apparatus and method for treating cardiovascular diseases |
EP2019633B1 (en) | 2006-04-28 | 2012-08-01 | Medtronic, Inc. | Devices for occlusion of an atrial appendage |
US8019435B2 (en) | 2006-05-02 | 2011-09-13 | Boston Scientific Scimed, Inc. | Control of arterial smooth muscle tone |
EP2015681B1 (en) | 2006-05-03 | 2018-03-28 | Datascope Corp. | Tissue closure device |
US8402974B2 (en) | 2006-05-30 | 2013-03-26 | Coherex Medical, Inc. | Methods, systems, and devices for sensing, measuring, and controlling closure of a patent foramen ovale |
US9220402B2 (en) | 2006-06-07 | 2015-12-29 | Intuitive Surgical Operations, Inc. | Visualization and treatment via percutaneous methods and devices |
EP2460543A1 (en) | 2006-06-30 | 2012-06-06 | Tyco Healthcare Group LP | Medical Devices with Amorphous Metals and Methods Therefor |
NZ573919A (en) | 2006-06-30 | 2012-08-31 | Cvdevices Llc | A system for engaging heart tisue utilising a vacuum for percutaneous intravascular access to cardiac tissue |
US8167894B2 (en) | 2006-08-09 | 2012-05-01 | Coherex Medical, Inc. | Methods, systems and devices for reducing the size of an internal tissue opening |
US9220487B2 (en) | 2006-08-09 | 2015-12-29 | Coherex Medical, Inc. | Devices for reducing the size of an internal tissue opening |
US8529597B2 (en) | 2006-08-09 | 2013-09-10 | Coherex Medical, Inc. | Devices for reducing the size of an internal tissue opening |
EP1891902A1 (en) | 2006-08-22 | 2008-02-27 | Carag AG | Occluding device |
US8870914B2 (en) | 2006-09-12 | 2014-10-28 | Cook Medical Technologies Llc | Medical device and a method for sealing a puncture or an opening |
US20100069925A1 (en) | 2006-09-21 | 2010-03-18 | Mayo Foundation For Medical Education And Research | Devices and methods for ligating anatomical structures |
CN101437978B (en) | 2006-11-27 | 2011-07-27 | 先健科技(深圳)有限公司 | Method for preparing nickle titanium alloy medical instrument surface coating |
US9345462B2 (en) | 2006-12-01 | 2016-05-24 | Boston Scientific Scimed, Inc. | Direct drive endoscopy systems and methods |
JP5443169B2 (en) | 2007-01-03 | 2014-03-19 | ミトラル・ソリューションズ・インコーポレイテッド | Implantable device for controlling the size and shape of an anatomical structure or lumen |
US8108069B2 (en) | 2007-01-10 | 2012-01-31 | Hansen Medical, Inc. | Robotic catheter system and methods |
WO2008091612A2 (en) | 2007-01-23 | 2008-07-31 | Cvdevices, Llc. | Devices, systems, and methods for percutaneous trans-septal left atrial appendage occlusi0n |
WO2009094237A1 (en) | 2008-01-23 | 2009-07-30 | Cvdevices, Llc | Devices, systems and methods for percutaneous trans-septal left atrial appendage occlusion |
US8784469B2 (en) | 2011-06-30 | 2014-07-22 | Ghassan S. Kassab | Devices, systems, and methods for inverting and closing the left atrial appendage |
WO2008097999A2 (en) | 2007-02-05 | 2008-08-14 | Mitralsolutions, Inc. | Minimally invasive system for delivering and securing an annular implant |
EP2574287B1 (en) | 2007-03-30 | 2015-04-22 | Sentreheart, Inc. | Devices for closing the left atrial appendage |
ES2426348T3 (en) | 2007-04-16 | 2013-10-22 | Occlutech Holding Ag | Occlusion instrument to close a heart apron and method to produce the same |
US8463359B2 (en) | 2007-04-25 | 2013-06-11 | Nidus Medical, Llc | Shape-sensing expandable member |
US8915958B2 (en) | 2007-06-08 | 2014-12-23 | St. Jude Medical, Inc. | Devices for transcatheter prosthetic heart valve implantation and access closure |
US8048147B2 (en) | 2007-06-27 | 2011-11-01 | Aga Medical Corporation | Branched stent/graft and method of fabrication |
US8034061B2 (en) | 2007-07-12 | 2011-10-11 | Aga Medical Corporation | Percutaneous catheter directed intravascular occlusion devices |
US8361138B2 (en) | 2007-07-25 | 2013-01-29 | Aga Medical Corporation | Braided occlusion device having repeating expanded volume segments separated by articulation segments |
EP4403141A2 (en) | 2007-08-02 | 2024-07-24 | OCCLUTECH GmbH | Medical implantable device and method for manufacture |
DE102007043830A1 (en) | 2007-09-13 | 2009-04-02 | Lozonschi, Lucian, Madison | Heart valve stent |
US9532868B2 (en) | 2007-09-28 | 2017-01-03 | St. Jude Medical, Inc. | Collapsible-expandable prosthetic heart valves with structures for clamping native tissue |
US9414842B2 (en) | 2007-10-12 | 2016-08-16 | St. Jude Medical, Cardiology Division, Inc. | Multi-component vascular device |
US9848981B2 (en) | 2007-10-12 | 2017-12-26 | Mayo Foundation For Medical Education And Research | Expandable valve prosthesis with sealing mechanism |
WO2009052432A2 (en) | 2007-10-19 | 2009-04-23 | Coherex Medical, Inc. | Medical device for modification of left atrial appendange and related systems and methods |
US9572583B2 (en) | 2007-11-21 | 2017-02-21 | St. Jude Medical, Atrial Fibrillation Division, Inc. | Methods and systems for occluding vessels during cardiac ablation |
US20090171386A1 (en) | 2007-12-28 | 2009-07-02 | Aga Medical Corporation | Percutaneous catheter directed intravascular occlusion devices |
US8235988B2 (en) | 2008-01-24 | 2012-08-07 | Coherex Medical, Inc. | Systems and methods for reduction of atrial fibrillation |
US8617145B2 (en) | 2008-01-25 | 2013-12-31 | Intrepid Medical, Inc. | Methods of treating a cardiac arrhythmia by thoracoscopic production of a Cox maze III lesion set |
WO2009099550A1 (en) | 2008-02-07 | 2009-08-13 | Cardiac Pacemakers, Inc. | Wireless tissue electrostimulation |
US8163004B2 (en) | 2008-02-18 | 2012-04-24 | Aga Medical Corporation | Stent graft for reinforcement of vascular abnormalities and associated method |
EP2262447B1 (en) | 2008-02-28 | 2015-08-12 | Medtronic, Inc. | Prosthetic heart valve systems |
US9241792B2 (en) | 2008-02-29 | 2016-01-26 | Edwards Lifesciences Corporation | Two-step heart valve implantation |
EP2282687A2 (en) | 2008-03-27 | 2011-02-16 | Mayo Foundation For Medical Education And Research | Navigation and tissue capture systems and methods |
US8540616B2 (en) | 2008-05-05 | 2013-09-24 | Coherex Medical, Inc. | Ventricular assist device and related methods |
US8235885B2 (en) | 2008-05-05 | 2012-08-07 | Coherex Medical, Inc. | Ventricular assist device and related methods |
US8454632B2 (en) | 2008-05-12 | 2013-06-04 | Xlumena, Inc. | Tissue anchor for securing tissue layers |
US8647254B2 (en) | 2008-07-01 | 2014-02-11 | Maquet Cardiovascular Llc | Epicardial clip |
US9232992B2 (en) | 2008-07-24 | 2016-01-12 | Aga Medical Corporation | Multi-layered medical device for treating a target site and associated method |
US20100030321A1 (en) | 2008-07-29 | 2010-02-04 | Aga Medical Corporation | Medical device including corrugated braid and associated method |
WO2010029190A1 (en) * | 2008-09-15 | 2010-03-18 | Joensson Anders | Medical device, method and system for temporary occlusion of an opening in a lumen of a body |
US8940015B2 (en) | 2008-11-11 | 2015-01-27 | Aga Medical Corporation | Asymmetrical medical devices for treating a target site and associated method |
US8021330B2 (en) * | 2008-11-14 | 2011-09-20 | Medtronic Vascular, Inc. | Balloon catheter for crossing a chronic total occlusion |
US9320525B2 (en) | 2008-12-03 | 2016-04-26 | Boston Scientific Scimed, Inc. | Occlusion stent |
US8308798B2 (en) | 2008-12-19 | 2012-11-13 | Edwards Lifesciences Corporation | Quick-connect prosthetic heart valve and methods |
US8550982B2 (en) | 2008-12-19 | 2013-10-08 | St. Jude Medical, Atrial Fibrillation Division, Inc. | Closed-chest stabilization system and methods for minimally invasive heart surgery |
WO2010081039A1 (en) | 2009-01-08 | 2010-07-15 | Coherex Medical, Inc. | Medical device for modification of left atrial appendage and related systems and methods |
EP2389121B1 (en) | 2009-01-22 | 2020-10-07 | St. Jude Medical, Cardiology Division, Inc. | Post-operative adjustment tool, minimally invasive attachment apparatus, and adjustable tricuspid ring |
US20100217382A1 (en) | 2009-02-25 | 2010-08-26 | Edwards Lifesciences | Mitral valve replacement with atrial anchoring |
US8747297B2 (en) | 2009-03-02 | 2014-06-10 | Olympus Corporation | Endoscopic heart surgery method |
US9980818B2 (en) | 2009-03-31 | 2018-05-29 | Edwards Lifesciences Corporation | Prosthetic heart valve system with positioning markers |
CA2961053C (en) | 2009-04-15 | 2019-04-30 | Edwards Lifesciences Cardiaq Llc | Vascular implant and delivery system |
ES2556530T3 (en) | 2009-04-16 | 2016-01-18 | Occlutech Holding Ag | Intravascular delivery device of a medical implant |
ES2397138T3 (en) | 2009-05-06 | 2013-03-05 | Occlutech Holding Ag | Intravascular delivery device |
JP5535313B2 (en) | 2009-05-29 | 2014-07-02 | エックスルミナ, インコーポレイテッド | Device and method for deploying a stent across adjacent tissue layers |
CH701269A1 (en) * | 2009-06-10 | 2010-12-15 | Carag Ag | Occluder. |
US9351716B2 (en) | 2009-06-17 | 2016-05-31 | Coherex Medical, Inc. | Medical device and delivery system for modification of left atrial appendage and methods thereof |
US9649115B2 (en) | 2009-06-17 | 2017-05-16 | Coherex Medical, Inc. | Medical device for modification of left atrial appendage and related systems and methods |
US10064628B2 (en) | 2009-06-17 | 2018-09-04 | Coherex Medical, Inc. | Medical device for modification of left atrial appendage and related systems and methods |
US9883864B2 (en) | 2009-06-17 | 2018-02-06 | Coherex Medical, Inc. | Medical device for modification of left atrial appendage and related systems and methods |
US8348998B2 (en) | 2009-06-26 | 2013-01-08 | Edwards Lifesciences Corporation | Unitary quick connect prosthetic heart valve and deployment system and methods |
EP2456504B1 (en) * | 2009-07-23 | 2019-06-19 | Hotspur Technologies, Inc | Apparatus for treating obstructions within body lumens |
US20110054515A1 (en) | 2009-08-25 | 2011-03-03 | John Bridgeman | Device and method for occluding the left atrial appendage |
US8801706B2 (en) | 2009-08-27 | 2014-08-12 | Medtronic, Inc. | Paravalvular leak closure devices and methods |
US10034748B2 (en) | 2009-09-18 | 2018-07-31 | The Regents Of The University Of California | Endovascular prosthetic heart valve replacement |
EP2482735A4 (en) | 2009-09-30 | 2017-03-29 | Mayo Foundation For Medical Education And Research | Enhanced signal navigation and capture systems and methods |
US9198683B2 (en) | 2009-09-30 | 2015-12-01 | Aegis Medical Innovations, Inc. | Tissue capture and occlusion systems and methods |
US9814562B2 (en) * | 2009-11-09 | 2017-11-14 | Covidien Lp | Interference-relief type delivery detachment systems |
US9795765B2 (en) | 2010-04-09 | 2017-10-24 | St. Jude Medical International Holding S.À R.L. | Variable stiffness steering mechanism for catheters |
CN104997574B (en) | 2010-04-13 | 2017-06-06 | 森特里心脏股份有限公司 | For the method and apparatus to Cardiac interventional and placing device |
US9192790B2 (en) | 2010-04-14 | 2015-11-24 | Boston Scientific Scimed, Inc. | Focused ultrasonic renal denervation |
EP2560580B1 (en) | 2010-04-21 | 2019-06-19 | Medtronic Inc. | Prosthetic valve with sealing members |
US8568474B2 (en) | 2010-04-26 | 2013-10-29 | Medtronic, Inc. | Transcatheter prosthetic heart valve post-dilatation remodeling devices and methods |
ES2403009T3 (en) | 2010-05-23 | 2013-05-13 | Occlutech Holding Ag | Braided medical device and method for its manufacture |
EP2387950A1 (en) | 2010-05-23 | 2011-11-23 | Occlutech Holding AG | Medical implant and manufacturing method thereof |
JP2013526993A (en) | 2010-06-02 | 2013-06-27 | ノンウォテック メディカル ゲーエムベーハー | Device for placement in a hollow organ, in particular a device for keeping a hollow organ open, and a method for manufacturing such a device |
WO2012021207A1 (en) | 2010-06-03 | 2012-02-16 | Kl Medical Llc | Pericardial devices, systems and methods for occluding an atrial appendage |
US8473067B2 (en) | 2010-06-11 | 2013-06-25 | Boston Scientific Scimed, Inc. | Renal denervation and stimulation employing wireless vascular energy transfer arrangement |
US9737309B1 (en) | 2010-06-24 | 2017-08-22 | Niv Ad | System for occlusion of left atrial appendage |
EP2584977A4 (en) | 2010-06-26 | 2017-08-09 | Vasostitch, Inc. | Method and apparatus for transapical access and closure |
US9326852B2 (en) | 2010-07-08 | 2016-05-03 | Benjamin Spenser | Method for implanting prosthetic valve |
US8408214B2 (en) | 2010-07-08 | 2013-04-02 | Benjamin Spenser | Method for implanting prosthetic valve |
US9358365B2 (en) | 2010-07-30 | 2016-06-07 | Boston Scientific Scimed, Inc. | Precision electrode movement control for renal nerve ablation |
US9155589B2 (en) | 2010-07-30 | 2015-10-13 | Boston Scientific Scimed, Inc. | Sequential activation RF electrode set for renal nerve ablation |
US9408661B2 (en) | 2010-07-30 | 2016-08-09 | Patrick A. Haverkost | RF electrodes on multiple flexible wires for renal nerve ablation |
US9084609B2 (en) | 2010-07-30 | 2015-07-21 | Boston Scientific Scime, Inc. | Spiral balloon catheter for renal nerve ablation |
US9463062B2 (en) | 2010-07-30 | 2016-10-11 | Boston Scientific Scimed, Inc. | Cooled conductive balloon RF catheter for renal nerve ablation |
CN101933839B (en) | 2010-08-26 | 2013-09-25 | 先健科技(深圳)有限公司 | Connecting device for mediatory type medical devices and using method thereof |
CN103179909A (en) | 2010-09-06 | 2013-06-26 | 诺沃泰科医药股份有限公司 | Device for closing openings or cavities in blood vessels |
US9370418B2 (en) | 2010-09-10 | 2016-06-21 | Edwards Lifesciences Corporation | Rapidly deployable surgical heart valves |
CN101933850B (en) | 2010-09-16 | 2012-07-18 | 先健科技(深圳)有限公司 | Stopper and manufacturing method thereof |
US8974451B2 (en) | 2010-10-25 | 2015-03-10 | Boston Scientific Scimed, Inc. | Renal nerve ablation using conductive fluid jet and RF energy |
US9220558B2 (en) | 2010-10-27 | 2015-12-29 | Boston Scientific Scimed, Inc. | RF renal denervation catheter with multiple independent electrodes |
US9028485B2 (en) | 2010-11-15 | 2015-05-12 | Boston Scientific Scimed, Inc. | Self-expanding cooling electrode for renal nerve ablation |
US9668811B2 (en) | 2010-11-16 | 2017-06-06 | Boston Scientific Scimed, Inc. | Minimally invasive access for renal nerve ablation |
US9089350B2 (en) | 2010-11-16 | 2015-07-28 | Boston Scientific Scimed, Inc. | Renal denervation catheter with RF electrode and integral contrast dye injection arrangement |
US9326751B2 (en) | 2010-11-17 | 2016-05-03 | Boston Scientific Scimed, Inc. | Catheter guidance of external energy for renal denervation |
US9060761B2 (en) | 2010-11-18 | 2015-06-23 | Boston Scientific Scime, Inc. | Catheter-focused magnetic field induced renal nerve ablation |
US8148470B1 (en) | 2010-11-19 | 2012-04-03 | Exxonmobil Chemical Patents Inc. | Processes for making multimodal molecular weight distribution polyolefins |
US9192435B2 (en) | 2010-11-22 | 2015-11-24 | Boston Scientific Scimed, Inc. | Renal denervation catheter with cooled RF electrode |
US9023034B2 (en) | 2010-11-22 | 2015-05-05 | Boston Scientific Scimed, Inc. | Renal ablation electrode with force-activatable conduction apparatus |
US20120157993A1 (en) | 2010-12-15 | 2012-06-21 | Jenson Mark L | Bipolar Off-Wall Electrode Device for Renal Nerve Ablation |
CN102525701B (en) | 2010-12-21 | 2015-06-17 | 先健科技(深圳)有限公司 | Absorbable blood vessel stent |
US9220561B2 (en) | 2011-01-19 | 2015-12-29 | Boston Scientific Scimed, Inc. | Guide-compatible large-electrode catheter for renal nerve ablation with reduced arterial injury |
US8777966B2 (en) | 2011-02-01 | 2014-07-15 | St. Jude Medical, Inc. | Apparatus and method for heart valve repair |
US8821529B2 (en) | 2011-03-25 | 2014-09-02 | Aga Medical Corporation | Device and method for occluding a septal defect |
US8511214B2 (en) | 2011-04-21 | 2013-08-20 | Aga Medical Corporation | Tubular structure and method for making the same |
WO2012158187A1 (en) | 2011-05-17 | 2012-11-22 | Boston Scientific Scimed, Inc. | Corkscrew annuloplasty device |
EP2709559B1 (en) | 2011-05-17 | 2015-01-21 | Boston Scientific Scimed, Inc. | Annuloplasty ring with anchors fixed by curing polymer |
CN102805654B (en) | 2011-06-01 | 2014-04-02 | 先健科技(深圳)有限公司 | Occluder for left auricle |
CA2838539C (en) | 2011-06-08 | 2020-08-04 | Sentreheart, Inc. | Tissue ligation devices and tensioning devices therefor |
US8764793B2 (en) | 2011-06-17 | 2014-07-01 | Northwestern University | Left atrial appendage occluder |
US8764787B2 (en) | 2011-06-17 | 2014-07-01 | Aga Medical Corporation | Occlusion device and associated deployment method |
EP2731493B1 (en) | 2011-07-11 | 2015-07-01 | The Regents of The University of Michigan | Multimodality left atrial appendage occlusion device |
AU2012283908B2 (en) | 2011-07-20 | 2017-02-16 | Boston Scientific Scimed, Inc. | Percutaneous devices and methods to visualize, target and ablate nerves |
CN103813829B (en) | 2011-07-22 | 2016-05-18 | 波士顿科学西美德公司 | There is the neuromodulation system of the neuromodulation element that can be positioned in spiral guiding piece |
US9339384B2 (en) | 2011-07-27 | 2016-05-17 | Edwards Lifesciences Corporation | Delivery systems for prosthetic heart valve |
EP2567663A1 (en) | 2011-09-09 | 2013-03-13 | Occlutech Holding AG | A collapsible medical closing device, a method and a medical system for delivering an object |
US9039752B2 (en) | 2011-09-20 | 2015-05-26 | Aga Medical Corporation | Device and method for delivering a vascular device |
US8621975B2 (en) | 2011-09-20 | 2014-01-07 | Aga Medical Corporation | Device and method for treating vascular abnormalities |
EP2572644A1 (en) | 2011-09-22 | 2013-03-27 | Occlutech Holding AG | Medical implantable occlusion device |
US9474598B2 (en) | 2011-10-05 | 2016-10-25 | Boston Scientific Scimed, Inc. | Profile reduction seal |
US9186210B2 (en) | 2011-10-10 | 2015-11-17 | Boston Scientific Scimed, Inc. | Medical devices including ablation electrodes |
EP2765940B1 (en) | 2011-10-11 | 2015-08-26 | Boston Scientific Scimed, Inc. | Off-wall electrode device for nerve modulation |
US9420955B2 (en) | 2011-10-11 | 2016-08-23 | Boston Scientific Scimed, Inc. | Intravascular temperature monitoring system and method |
US9364284B2 (en) | 2011-10-12 | 2016-06-14 | Boston Scientific Scimed, Inc. | Method of making an off-wall spacer cage |
WO2013058962A1 (en) | 2011-10-18 | 2013-04-25 | Boston Scientific Scimed, Inc. | Deflectable medical devices |
EP2768568B1 (en) | 2011-10-18 | 2020-05-06 | Boston Scientific Scimed, Inc. | Integrated crossing balloon catheter |
AU2012325813A1 (en) | 2011-10-19 | 2014-04-03 | Twelve, Inc. | Prosthetic heart valve devices, prosthetic mitral valves and associated systems and methods |
CN104168839A (en) | 2011-10-27 | 2014-11-26 | 奥特鲁泰克控股有限公司 | Medical implant for occluding an opening in a body and a method of producing such a medical implant |
USD713527S1 (en) | 2011-10-31 | 2014-09-16 | Occlutech Holding Ag | Occlusion device |
EP4324409A3 (en) | 2011-11-01 | 2024-03-13 | Coherex Medical, Inc. | Medical device for modification of left atrial appendage and related systems and methods |
CN108095821B (en) | 2011-11-08 | 2021-05-25 | 波士顿科学西美德公司 | Orifice renal nerve ablation |
CN103987325B (en) | 2011-11-08 | 2017-03-29 | 波士顿科学国际有限公司 | For the Handleset of left atrial appendage occlusion device |
WO2013068466A1 (en) | 2011-11-09 | 2013-05-16 | Universität Zürich | System for occluding a left atrial appendage |
US9119600B2 (en) | 2011-11-15 | 2015-09-01 | Boston Scientific Scimed, Inc. | Device and methods for renal nerve modulation monitoring |
US8758389B2 (en) | 2011-11-18 | 2014-06-24 | Aga Medical Corporation | Devices and methods for occluding abnormal openings in a patient's vasculature |
US9119632B2 (en) | 2011-11-21 | 2015-09-01 | Boston Scientific Scimed, Inc. | Deflectable renal nerve ablation catheter |
WO2013076276A1 (en) | 2011-11-23 | 2013-05-30 | Occlutech Holding Ag | Medical occlusion device |
US9492156B2 (en) | 2011-11-28 | 2016-11-15 | St. Jude Medical Puerto Rico Llc | Large bore anchor device |
US9174050B2 (en) | 2011-12-23 | 2015-11-03 | Vessix Vascular, Inc. | Methods and apparatuses for remodeling tissue of or adjacent to a body passage |
CN104135958B (en) | 2011-12-28 | 2017-05-03 | 波士顿科学西美德公司 | By the apparatus and method that have the new ablation catheter modulation nerve of polymer ablation |
US9050106B2 (en) | 2011-12-29 | 2015-06-09 | Boston Scientific Scimed, Inc. | Off-wall electrode device and methods for nerve modulation |
EP2620125B1 (en) | 2012-01-24 | 2017-10-11 | Medtentia International Ltd Oy | An arrangement, a loop-shaped support, a prosthetic heart valve and a method of repairing or replacing a native heart valve |
WO2013112797A2 (en) | 2012-01-25 | 2013-08-01 | St. Jude Medical, Inc. | Apparatus and method for heart valve repair |
US9610082B2 (en) | 2012-01-25 | 2017-04-04 | St. Jude Medical, Inc. | Apparatus and method for heart valve repair |
EP2809270B1 (en) | 2012-02-02 | 2017-05-31 | St. Jude Medical, Cardiology Division, Inc. | Apparatus for heart valve repair |
US9113890B2 (en) | 2012-02-06 | 2015-08-25 | Aga Medical Corporation | Devices and methods for occluding vascular abnormalities |
EP2819585B1 (en) | 2012-02-29 | 2017-11-29 | Occlutech Holding AG | A device for occluding an opening in a body and associated methods |
IN2014MN01875A (en) | 2012-03-07 | 2015-07-03 | Cancer Res Inst Royal | |
CA2869365A1 (en) | 2012-04-05 | 2013-10-10 | Mvalve Technologies Ltd. | Cardiac valve support structure |
CN103371876B (en) | 2012-04-12 | 2016-01-20 | 先健科技(深圳)有限公司 | The medical apparatus and instruments of biological absorbable or medical device element, and preparation method thereof |
USD728102S1 (en) | 2012-04-30 | 2015-04-28 | Occlutech Holding Ag | Occlusion device |
USD727500S1 (en) | 2012-04-30 | 2015-04-21 | Occlutech Holding Ag | Occlusion device |
USD727501S1 (en) | 2012-04-30 | 2015-04-21 | Occlutech Holdings AG | Occlusion devices |
KR102127539B1 (en) | 2012-06-05 | 2020-06-26 | 카르디오지 | Endoprosthesis and delivery device for implanting such endoprosthesis |
US10013082B2 (en) | 2012-06-05 | 2018-07-03 | Stuart Schecter, LLC | Operating system with haptic interface for minimally invasive, hand-held surgical instrument |
US9427235B2 (en) | 2012-06-19 | 2016-08-30 | Subramaniam Chitoor Krishnan | Apparatus and method for treating bleeding arising from left atrial appendage |
US10052168B2 (en) | 2012-06-19 | 2018-08-21 | Subramaniam Chitoor Krishnan | Methods and systems for preventing bleeding from the left atrial appendage |
ES2626878T3 (en) | 2012-07-13 | 2017-07-26 | Boston Scientific Scimed, Inc. | Occlusion device for an atrial appendage |
US10105219B2 (en) | 2012-08-02 | 2018-10-23 | St. Jude Medical, Cardiology Division, Inc. | Mitral valve leaflet clip |
US9277905B2 (en) | 2012-08-02 | 2016-03-08 | W. L. Gore & Associates, Inc. | Space-filling device |
US9125653B2 (en) | 2012-08-02 | 2015-09-08 | St. Jude Medical, Cardiology Division, Inc. | Flexible nosecone for percutaneous device |
US9662205B2 (en) | 2012-08-02 | 2017-05-30 | St. Jude Medical, Cardiology Division, Inc. | Apparatus and method for heart valve repair |
US9254141B2 (en) | 2012-08-02 | 2016-02-09 | St. Jude Medical, Inc. | Apparatus and method for heart valve repair |
WO2014021937A1 (en) | 2012-08-03 | 2014-02-06 | St. Jude Medical Puerto Rico Llc | Large bore introducer with improved seal |
US9585643B2 (en) | 2012-08-21 | 2017-03-07 | St. Jude Medical Puerto Rico Llc | Carrier tubes for closure devices |
EP2887905B1 (en) | 2012-08-22 | 2020-03-11 | Krishnan, Subramaniam, Chitoor | Systems for accessing a pericardial space and preventing strokes arising from the left atrial appendage |
WO2014031147A1 (en) | 2012-08-24 | 2014-02-27 | St. Jude Medical Puerto Rico Llc | Balloon bailout and bioadhesive delivery device for suture based closure and methods |
EP2895095A2 (en) | 2012-09-17 | 2015-07-22 | Boston Scientific Scimed, Inc. | Self-positioning electrode system and method for renal nerve modulation |
US20140100596A1 (en) * | 2012-10-09 | 2014-04-10 | Boston Scientific Scimed, Inc. | Centered balloon for the left atrial appendage |
US9066710B2 (en) | 2012-10-19 | 2015-06-30 | St. Jude Medical, Cardiology Division, Inc. | Apparatus and method for heart valve repair |
WO2014066389A1 (en) | 2012-10-22 | 2014-05-01 | The Cleveland Clinic Foundation | Apparatus and method for targeting a body tissue |
US9144663B2 (en) | 2012-10-24 | 2015-09-29 | Medtronic, Inc. | Methods and devices for repairing and/or preventing paravalvular leakage post-implantation of a valve prosthesis |
CN102973341B (en) | 2012-11-08 | 2015-06-17 | 先健科技(深圳)有限公司 | Braided self-expanding type tube cavity support and manufacturing method thereof |
WO2014074132A1 (en) | 2012-11-09 | 2014-05-15 | Aga Medical Corporation | Devices and methods for delivering vascular implants |
US9408951B2 (en) | 2012-11-13 | 2016-08-09 | Boston Scientific Scimed, Inc. | Nanoparticle implantation in medical devices |
US9072602B2 (en) | 2012-11-14 | 2015-07-07 | Medtronic, Inc. | Transcatheter valve prosthesis having a variable shaped cross-section for preventing paravalvular leakage |
CN103007361B (en) | 2012-12-21 | 2015-07-01 | 先健科技(深圳)有限公司 | Medical apparatus coating and preparation method thereof and medical apparatus containing costing |
CN104994794A (en) | 2012-12-31 | 2015-10-21 | 波士顿科学医学有限公司 | Medical devices having fixation anchor |
US9132007B2 (en) | 2013-01-10 | 2015-09-15 | Medtronic CV Luxembourg S.a.r.l. | Anti-paravalvular leakage components for a transcatheter valve prosthesis |
US9131932B2 (en) | 2013-02-01 | 2015-09-15 | St. Jude Medical Puerto Rico Llc | Dual lumen carrier tube with retractable sleeve and methods |
US9675451B2 (en) | 2013-02-01 | 2017-06-13 | Medtronic CV Luxembourg S.a.r.l. | Anti-paravalvular leakage component for a transcatheter valve prosthesis |
CN103142261B (en) | 2013-02-04 | 2016-01-20 | 先健科技(深圳)有限公司 | A kind of stopper with the flat card of included-angle-changeable |
US9456897B2 (en) | 2013-02-21 | 2016-10-04 | Medtronic, Inc. | Transcatheter valve prosthesis and a concurrently delivered sealing component |
US9301838B2 (en) | 2013-02-26 | 2016-04-05 | The Cleveland Clinic Foundation | Apparatus and method for delivering a structure to a desired target site |
US9339385B2 (en) | 2013-03-07 | 2016-05-17 | St. Jude Medical, Cardiology Division, Inc. | Balloon release mechanism for TAVI implant |
US9775533B2 (en) | 2013-03-08 | 2017-10-03 | Singapore Health Services Pte Ltd | System and method of determining a risk score for triage |
US10028746B2 (en) | 2013-03-08 | 2018-07-24 | St. Jude Medical, Cardiology Division, Inc. | Medical device for treating a target site |
US9681861B2 (en) | 2013-03-11 | 2017-06-20 | St. Jude Medical, Cardiology Division, Inc. | Percutaneous catheter directed collapsible medical closure device |
WO2014163987A1 (en) | 2013-03-11 | 2014-10-09 | Boston Scientific Scimed, Inc. | Medical devices for modulating nerves |
WO2014143571A1 (en) | 2013-03-11 | 2014-09-18 | Boston Scientific Scimed, Inc. | Medical devices for modulating nerves |
US9642706B2 (en) | 2013-03-11 | 2017-05-09 | St. Jude Medical, Llc | Apparatus and method for heart valve repair |
US10271949B2 (en) | 2013-03-12 | 2019-04-30 | St. Jude Medical, Cardiology Division, Inc. | Paravalvular leak occlusion device for self-expanding heart valves |
EP2967849A4 (en) | 2013-03-12 | 2017-01-18 | St. Jude Medical, Cardiology Division, Inc. | Self-actuating sealing portions for paravalvular leak protection |
ES2671796T3 (en) | 2013-03-12 | 2018-06-08 | Sentreheart, Inc. | Tissue ligation device |
US9636222B2 (en) | 2013-03-12 | 2017-05-02 | St. Jude Medical, Cardiology Division, Inc. | Paravalvular leak protection |
US9055933B2 (en) | 2013-03-12 | 2015-06-16 | St. Jude Medical Puerto Rico Llc | Large bore closure secondary hemostasis bioadhesive delivery systems and methods |
US9398951B2 (en) | 2013-03-12 | 2016-07-26 | St. Jude Medical, Cardiology Division, Inc. | Self-actuating sealing portions for paravalvular leak protection |
CN105073068B (en) | 2013-03-12 | 2017-03-15 | 爱德华兹生命科学公司 | Can rapid deployment Surgical heart valve |
US9339274B2 (en) | 2013-03-12 | 2016-05-17 | St. Jude Medical, Cardiology Division, Inc. | Paravalvular leak occlusion device for self-expanding heart valves |
US8986375B2 (en) | 2013-03-12 | 2015-03-24 | Medtronic, Inc. | Anti-paravalvular leakage component for a transcatheter valve prosthesis |
WO2014164572A1 (en) | 2013-03-13 | 2014-10-09 | Kaplan Aaron V | Devices and methods for excluding the left atrial appendage |
US9290612B2 (en) | 2013-03-13 | 2016-03-22 | Tepha, Inc. | Compositions and devices of poly-4-hydroxybutyrate |
US9808311B2 (en) | 2013-03-13 | 2017-11-07 | Boston Scientific Scimed, Inc. | Deflectable medical devices |
CN105228546B (en) | 2013-03-15 | 2017-11-14 | 波士顿科学国际有限公司 | Utilize the impedance-compensated medicine equipment and method that are used to treat hypertension |
JP6220044B2 (en) | 2013-03-15 | 2017-10-25 | ボストン サイエンティフィック サイムド,インコーポレイテッドBoston Scientific Scimed,Inc. | Medical device for renal nerve ablation |
US9089414B2 (en) | 2013-03-22 | 2015-07-28 | Edwards Lifesciences Corporation | Device and method for increasing flow through the left atrial appendage |
EP3038537A1 (en) | 2013-05-30 | 2016-07-06 | Malakan Rad, Elaheh | Asymmetric occluder device |
CN104207866B (en) | 2013-05-30 | 2016-12-07 | 深圳市先健生物材料技术有限公司 | The medical apparatus and instruments of biological absorbable or the manufacture method of its absorbable parts |
WO2014204807A1 (en) | 2013-06-19 | 2014-12-24 | Aga Medical Corporation | Collapsible valve having paravalvular leak protection |
JP2016523147A (en) | 2013-06-21 | 2016-08-08 | ボストン サイエンティフィック サイムド,インコーポレイテッドBoston Scientific Scimed,Inc. | Renal denervation balloon catheter with a riding-type electrode support |
WO2014205399A1 (en) | 2013-06-21 | 2014-12-24 | Boston Scientific Scimed, Inc. | Medical devices for renal nerve ablation having rotatable shafts |
US9707036B2 (en) | 2013-06-25 | 2017-07-18 | Boston Scientific Scimed, Inc. | Devices and methods for nerve modulation using localized indifferent electrodes |
US9668856B2 (en) | 2013-06-26 | 2017-06-06 | St. Jude Medical, Cardiology Division, Inc. | Puckering seal for reduced paravalvular leakage |
EP3016614A1 (en) | 2013-07-01 | 2016-05-11 | St. Jude Medical, Cardiology Division, Inc. | Hybrid orientation pravalvular sealing stent |
CN105358084B (en) | 2013-07-01 | 2018-11-09 | 波士顿科学国际有限公司 | Medical instrument for renal nerve ablation |
US9925001B2 (en) | 2013-07-19 | 2018-03-27 | Boston Scientific Scimed, Inc. | Spiral bipolar electrode renal denervation balloon |
US9687585B2 (en) | 2013-08-20 | 2017-06-27 | Tepha, Inc. | Thermoformed poly-4-hydroxybutyrate medical implants |
US9895194B2 (en) | 2013-09-04 | 2018-02-20 | Boston Scientific Scimed, Inc. | Radio frequency (RF) balloon catheter having flushing and cooling capability |
EP3044221B1 (en) | 2013-09-11 | 2018-02-21 | Institute of Cancer Research: Royal Cancer Hospital (The) | 3-aryl-5-substituted-isoquinolin-1-one compounds and their therapeutic use |
GB201316349D0 (en) | 2013-09-13 | 2013-10-30 | Ucl Business Plc | Vascular implant |
CN105592778B (en) | 2013-10-14 | 2019-07-23 | 波士顿科学医学有限公司 | High-resolution cardiac mapping electrod-array conduit |
US9962223B2 (en) | 2013-10-15 | 2018-05-08 | Boston Scientific Scimed, Inc. | Medical device balloon |
US9770606B2 (en) | 2013-10-15 | 2017-09-26 | Boston Scientific Scimed, Inc. | Ultrasound ablation catheter with cooling infusion and centering basket |
CN104587534A (en) | 2013-10-31 | 2015-05-06 | 先健科技(深圳)有限公司 | An absorbable iron-base alloy support |
US9913715B2 (en) | 2013-11-06 | 2018-03-13 | St. Jude Medical, Cardiology Division, Inc. | Paravalvular leak sealing mechanism |
EP2870946B1 (en) | 2013-11-06 | 2018-10-31 | St. Jude Medical, Cardiology Division, Inc. | Paravalvular leak sealing mechanism |
US9889004B2 (en) | 2013-11-19 | 2018-02-13 | St. Jude Medical, Cardiology Division, Inc. | Sealing structures for paravalvular leak protection |
CN103598929B (en) | 2013-11-28 | 2016-04-20 | 先健科技(深圳)有限公司 | Thoracic aorta covered bracket |
CN103736154B (en) | 2013-12-26 | 2015-06-17 | 先健科技(深圳)有限公司 | Medicinal coating balloon catheter |
US9839431B2 (en) | 2014-01-14 | 2017-12-12 | St. Jude Medical, Cardiology Division Inc. | Occlusion devices and methods of making and using same |
US9730701B2 (en) | 2014-01-16 | 2017-08-15 | Boston Scientific Scimed, Inc. | Retrieval wire centering device |
US9820852B2 (en) | 2014-01-24 | 2017-11-21 | St. Jude Medical, Cardiology Division, Inc. | Stationary intra-annular halo designs for paravalvular leak (PVL) reduction—active channel filling cuff designs |
JP6325121B2 (en) | 2014-02-04 | 2018-05-16 | ボストン サイエンティフィック サイムド,インコーポレイテッドBoston Scientific Scimed,Inc. | Alternative placement of temperature sensors on bipolar electrodes |
US9072604B1 (en) | 2014-02-11 | 2015-07-07 | Gilberto Melnick | Modular transcatheter heart valve and implantation method |
US9949825B2 (en) | 2014-02-18 | 2018-04-24 | St. Jude Medical, Cardiology Division, Inc. | Bowed runners and corresponding valve assemblies for paravalvular leak protection |
US20170014115A1 (en) * | 2014-03-27 | 2017-01-19 | Transmural Systems Llc | Devices and methods for closure of transvascular or transcameral access ports |
WO2015152980A1 (en) | 2014-03-31 | 2015-10-08 | St. Jude Medical, Cardiology Division, Inc. | Paravalvular sealing via extended cuff mechanisms |
JP6302131B2 (en) | 2014-03-31 | 2018-03-28 | ジトメッド・エスピー・ゼット・オー・オーJitmed Sp Z O.O. | Left atrial appendage obturator |
EP3142604B1 (en) | 2014-05-16 | 2024-01-10 | St. Jude Medical, Cardiology Division, Inc. | Transcatheter valve with paravalvular leak sealing ring |
WO2015175524A1 (en) | 2014-05-16 | 2015-11-19 | St. Jude Medical, Cardiology Division, Inc. | Subannular sealing for paravalvular leak protection |
US9757230B2 (en) | 2014-05-16 | 2017-09-12 | St. Jude Medical, Cardiology Division, Inc. | Stent assembly for use in prosthetic heart valves |
US9808201B2 (en) | 2014-08-18 | 2017-11-07 | St. Jude Medical, Cardiology Division, Inc. | Sensors for prosthetic heart devices |
EP3183012B1 (en) | 2014-08-20 | 2017-12-20 | Tepha, Inc. | Thermoformed poly-4-hydroxybutyrate medical implants |
JP6577574B2 (en) | 2014-09-09 | 2019-09-18 | オクルテック ホールディング エージー | Heart flow control device |
US9750605B2 (en) | 2014-10-23 | 2017-09-05 | Caisson Interventional, LLC | Systems and methods for heart valve therapy |
PL3273866T3 (en) | 2015-03-24 | 2024-05-13 | Atricure, Inc. | Devices for left atrial appendage closure |
ES2972395T3 (en) | 2015-03-24 | 2024-06-12 | Atricure Inc | Tissue ligation devices |
US20180161039A1 (en) | 2015-06-19 | 2018-06-14 | Koninklijke Philips N.V. | Implantable medical device and system to heat tissue |
US20170035433A1 (en) | 2015-08-06 | 2017-02-09 | Thomas J. Forbes | Left atrial appendage occluder device anchoring system, anchor, and method of attachment |
US9622133B1 (en) | 2015-10-23 | 2017-04-11 | The Florida International University Board Of Trustees | Interference and mobility management in UAV-assisted wireless networks |
WO2017079234A1 (en) | 2015-11-02 | 2017-05-11 | Edwards Lifesciences Corporation | Devices and methods for reducing cardiac valve regurgitation |
US9931204B2 (en) | 2015-12-10 | 2018-04-03 | Medtronic, Inc. | Transcatheter heart valve replacement systems, heart valve prostheses, and methods for percutaneous heart valve replacement |
US9955971B2 (en) | 2015-12-30 | 2018-05-01 | Lifetech Scientific (Shenzhen) Co. Ltd. | Method for treating aortic arch diseases |
WO2017161283A1 (en) | 2016-03-17 | 2017-09-21 | Swaminathan Jayaraman | Occluding anatomical structures |
US9974649B2 (en) | 2016-03-24 | 2018-05-22 | Medtronic Vascular, Inc. | Stented prosthetic heart valve having wrap and methods of delivery and deployment |
WO2018185255A1 (en) | 2017-04-05 | 2018-10-11 | National University Of Ireland, Galway | An implantable medical device |
EP3459469A1 (en) | 2017-09-23 | 2019-03-27 | Universität Zürich | Medical occluder device |
US20210204961A1 (en) * | 2017-09-23 | 2021-07-08 | Universität Zürich | Medical occlusion device |
US9919080B1 (en) | 2017-10-27 | 2018-03-20 | Tyrx, Inc. | Kits for local delivery of water soluble agents and methods of use |
-
2017
- 2017-09-23 EP EP17192792.4A patent/EP3459469A1/en not_active Withdrawn
-
2018
- 2018-09-23 CN CN201880061656.0A patent/CN111212607B/en active Active
- 2018-09-23 US US16/649,777 patent/US11517319B2/en active Active
- 2018-09-23 EP EP18773186.4A patent/EP3684270A1/en active Pending
- 2018-09-23 JP JP2020516870A patent/JP2020534109A/en active Pending
- 2018-09-23 WO PCT/EP2018/075716 patent/WO2019057950A1/en active Application Filing
-
2019
- 2019-03-26 JP JP2021516654A patent/JP7503228B2/en active Active
- 2019-03-26 EP EP19862977.6A patent/EP3852644A4/en active Pending
- 2019-03-26 WO PCT/US2019/024065 patent/WO2020060587A1/en active Application Filing
- 2019-03-26 CN CN201980072797.7A patent/CN112955079A/en active Pending
Patent Citations (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3834394A (en) * | 1969-11-21 | 1974-09-10 | R Sessions | Occlusion device and method and apparatus for inserting the same |
US5853422A (en) * | 1996-03-22 | 1998-12-29 | Scimed Life Systems, Inc. | Apparatus and method for closing a septal defect |
US6273907B1 (en) * | 1997-04-07 | 2001-08-14 | Broncus Technologies, Inc. | Bronchial stenter |
WO2003039624A2 (en) * | 2001-11-06 | 2003-05-15 | Possis Medical Inc. | Guidewire occlusion system utilizing repeatably inflatable gas-filled occlusive device |
WO2005092204A2 (en) * | 2004-03-22 | 2005-10-06 | Accessclosure, Inc. | Apparatus for sealing a vascular puncture |
CN105120798A (en) * | 2012-11-27 | 2015-12-02 | 康特戈医疗有限责任公司 | Percutaneous transluminal angioplasty device with integral embolic filter |
CN104905890A (en) * | 2014-03-14 | 2015-09-16 | 徐州亚太科技有限公司 | Novel degradable stopper implanted through guide pipe and conveying system of novel degradable stopper |
WO2016149653A2 (en) * | 2015-03-19 | 2016-09-22 | Prytime Medical Devices, Inc. | System and method for low-profile occlusion balloon catheter |
CN204971415U (en) * | 2015-06-01 | 2016-01-20 | 武功县人民医院 | Plugging device of transsphenoidal approach pituitary adenoma postsurgical sphenoid sinus |
CN106344082A (en) * | 2016-09-28 | 2017-01-25 | 宁波迪创医疗科技有限公司 | Volume reduction device for left ventricle |
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WO2020060587A1 (en) | 2020-03-26 |
WO2019057950A1 (en) | 2019-03-28 |
CN111212607A (en) | 2020-05-29 |
EP3684270A1 (en) | 2020-07-29 |
JP2022502144A (en) | 2022-01-11 |
EP3852644A4 (en) | 2023-01-18 |
JP2020534109A (en) | 2020-11-26 |
EP3459469A1 (en) | 2019-03-27 |
EP3852644A1 (en) | 2021-07-28 |
WO2020060587A8 (en) | 2020-05-22 |
US11517319B2 (en) | 2022-12-06 |
JP7503228B2 (en) | 2024-06-20 |
US20200275935A1 (en) | 2020-09-03 |
CN112955079A (en) | 2021-06-11 |
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