CN111189883A - Blood sugar detection system and method - Google Patents

Blood sugar detection system and method Download PDF

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Publication number
CN111189883A
CN111189883A CN202010052583.8A CN202010052583A CN111189883A CN 111189883 A CN111189883 A CN 111189883A CN 202010052583 A CN202010052583 A CN 202010052583A CN 111189883 A CN111189883 A CN 111189883A
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blood glucose
feedback signal
alternating current
direct current
glucose test
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王建国
张佳一
王建军
戴金良
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Hangzhou Ruimeng Technology Co ltd
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Hangzhou Ruimeng Technology Co ltd
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    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N27/00Investigating or analysing materials by the use of electric, electrochemical, or magnetic means

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Abstract

The application discloses blood sugar detecting system includes: the alternating current generation module is used for generating alternating current voltage with preset amplitude and preset frequency; the alternating current detection module is used for applying alternating current voltage to the blood glucose test paper to be detected to obtain an alternating current feedback signal; the direct current detection module is used for applying direct current voltage to the blood glucose test paper to be detected to obtain a direct current feedback signal; and the data processing module is used for determining the blood glucose concentration corresponding to the blood glucose test paper to be tested according to the alternating current feedback signal and the direct current feedback signal. The alternating current test of the blood glucose test paper to be tested is realized by the alternating current generation module and the alternating current detection module, and the final blood glucose concentration is determined by using two different test environments of alternating current and direct current, so that the test result is more comprehensive, and each result is more accurate. Correspondingly, the application also discloses a blood sugar detection method with the same beneficial effect.

Description

Blood sugar detection system and method
Technical Field
The invention relates to the field of test instruments, in particular to a blood sugar detection system and a blood sugar detection method.
Background
At present, there is no effective cure means for diabetes, and generally, the blood glucose concentration is controlled by performing corresponding means such as medication and insulin injection by detecting the blood glucose concentration of a patient at any time, so as to prevent the progress of the disease. Therefore, it is the development direction of the current blood sugar detection system to detect the blood sugar concentration as accurately as possible, and the more mature methods include a biochemical blood drawing method, a minimally invasive method and a non-invasive method. The biochemical blood drawing method needs professional detection equipment which is usually only available in professional institutions; the non-invasive method detects through photo-thermal information, although the detection can be carried out at any time, the system detection precision is poor due to environmental interference and differences of individual constitutions; the minimally invasive method collects blood by using test paper, is inserted into blood sugar detection equipment for determination, and has both accuracy and convenience.
However, the conventional blood glucose monitoring device cannot fully represent blood components, and thus the result of blood glucose concentration still has a variation.
Therefore, how to provide a solution to the above technical problems is a problem to be solved by those skilled in the art.
Disclosure of Invention
In view of the above, the present invention provides a blood glucose detecting system and method with high accuracy. The specific scheme is as follows:
a blood glucose detection system comprising:
the alternating current generation module is used for generating alternating current voltage with preset amplitude and preset frequency;
the alternating current detection module is used for applying the alternating current voltage to the blood glucose test paper to be detected to obtain an alternating current feedback signal;
the direct current detection module is used for applying direct current voltage to the blood glucose test paper to be detected to obtain a direct current feedback signal;
and the data processing module is used for determining the blood glucose concentration corresponding to the blood glucose test paper to be tested according to the alternating current feedback signal and the direct current feedback signal.
Preferably, the blood glucose detecting system further comprises:
the temperature detection module is used for detecting the current environment temperature;
the data processing module is also used for carrying out temperature compensation on the blood glucose concentration according to the environment temperature.
Preferably, the data processing module is specifically configured to:
when no blood sample is added to the blood glucose test paper to be detected, acquiring an alternating current background signal of the alternating current detection module and a direct current background signal of the direct current detection module;
preprocessing the alternating current feedback signal and the direct current feedback signal according to the alternating current background signal and the direct current background signal respectively;
and determining the blood glucose concentration according to the preprocessed alternating current feedback signal and the preprocessed direct current feedback signal.
Preferably, the blood glucose detecting system further comprises:
and the resistance detection module is used for detecting the resistance value of the blood glucose test strip to be detected so as to determine whether the batch or the resistance code of the blood glucose test strip to be detected is suitable for the blood glucose detection system.
Preferably, the preset frequency is 3.2 kHz.
Preferably, the blood glucose detecting system further comprises:
the analog-to-digital conversion module is used for performing analog-to-digital conversion on the alternating current feedback signal and the direct current feedback signal;
and the precision selection module is used for setting the precision of the analog-to-digital conversion module.
Preferably, the analog-to-digital conversion module is specifically configured to:
and performing analog-to-digital conversion on the alternating current feedback signal and the direct current feedback signal through an oversampling ADC.
Correspondingly, the invention also discloses a blood sugar detection method, which comprises the following steps:
applying direct current voltage to the blood glucose test paper to be tested to obtain a direct current feedback signal;
applying alternating voltage to the blood glucose test paper to be tested to obtain an alternating feedback signal;
and determining the blood glucose concentration corresponding to the blood glucose test paper to be tested according to the direct current feedback signal and the alternating current feedback signal.
Preferably, the blood glucose detecting method further comprises:
acquiring the current environment temperature;
and performing temperature compensation on the blood glucose concentration according to the environment temperature.
Preferably, the process of applying a dc voltage to the blood glucose test strip to be tested to obtain a dc feedback signal specifically includes:
applying direct-current voltage to the blood glucose test paper to be tested for multiple times to obtain a plurality of first feedback signals, and averaging the first feedback signals to obtain direct-current feedback signals;
correspondingly, the process of applying an alternating voltage to the blood glucose test paper to be tested to obtain an alternating feedback signal specifically comprises:
and applying alternating voltage to the blood glucose test paper to be tested to obtain a plurality of second feedback signals, and averaging the plurality of second feedback signals to obtain alternating feedback signals.
The invention discloses a blood sugar detection system, comprising: the alternating current generation module is used for generating alternating current voltage with preset amplitude and preset frequency; the alternating current detection module is used for applying the alternating current voltage to the blood glucose test paper to be detected to obtain an alternating current feedback signal; the direct current detection module is used for applying direct current voltage to the blood glucose test paper to be detected to obtain a direct current feedback signal; and the data processing module is used for determining the blood glucose concentration corresponding to the blood glucose test paper to be tested according to the alternating current feedback signal and the direct current feedback signal. According to the invention, the alternating current test of the blood glucose test paper to be tested is realized by using the alternating current generation module and the alternating current detection module, and the final blood glucose concentration is determined by using two different test environments of alternating current and direct current, so that the test result is more comprehensive, the blood glucose test precision is improved, and each result is more accurate.
Drawings
In order to more clearly illustrate the embodiments of the present invention or the technical solutions in the prior art, the drawings used in the description of the embodiments or the prior art will be briefly described below, it is obvious that the drawings in the following description are only embodiments of the present invention, and for those skilled in the art, other drawings can be obtained according to the provided drawings without creative efforts.
FIG. 1 is a schematic diagram of a blood glucose monitoring system according to an embodiment of the present invention;
fig. 2 is a structural distribution diagram of a blood glucose detecting method according to an embodiment of the present invention.
Detailed Description
The technical solutions in the embodiments of the present invention will be clearly and completely described below with reference to the drawings in the embodiments of the present invention, and it is obvious that the described embodiments are only a part of the embodiments of the present invention, and not all of the embodiments. All other embodiments, which can be derived by a person skilled in the art from the embodiments given herein without making any creative effort, shall fall within the protection scope of the present invention.
The existing blood sugar detection equipment cannot comprehensively reflect blood components, so that the result of blood sugar concentration still has deviation. According to the invention, the alternating current test of the blood glucose test paper to be tested is realized by using the alternating current generation module and the alternating current detection module, and the final blood glucose concentration is determined by using two different test environments of alternating current and direct current, so that the test result is more comprehensive, the blood glucose test precision is improved, and each result is more accurate.
The embodiment of the invention discloses a blood sugar detection system, which is shown in figure 1 and comprises:
the alternating current generating module 1 is used for generating alternating current voltage with preset amplitude and preset frequency;
the alternating current detection module 2 is used for applying alternating current voltage to the blood glucose test paper to be detected to obtain an alternating current feedback signal;
the direct current detection module 3 is used for applying direct current voltage to the blood glucose test paper to be detected to obtain a direct current feedback signal;
and the data processing module 4 is used for determining the blood glucose concentration corresponding to the blood glucose test paper to be tested according to the alternating current feedback signal and the direct current feedback signal.
The preset frequency of the alternating voltage generated in the alternating current generation module 1 is usually 3.2kHz, the preset frequency is set according to the resistance-capacitance characteristics of blood, the amplitude of the preset frequency can be set and adjusted according to the actual setting, usually about 30mV, and the amplitude is output to the alternating current detection module 2 after passing through a second-order active filter.
It can be understood that the coupling coefficients of the blood glucose test paper to be tested to the alternating voltage before and after adding the blood sample are different, the alternating current detection module 2 receives an alternating current feedback signal of the alternating current response of the blood glucose test paper to be tested, and the alternating current feedback signal is amplified and subjected to wave crest detection to obtain an alternating current test result.
Similarly, the feedback current of the blood glucose test paper to be tested to the direct current voltage is different before and after the blood sample is added, the direct current detection module 3 detects the direct current feedback signal of the direct current response of the blood glucose test paper to be tested, and the direct current feedback signal is subjected to current-voltage conversion and amplification to obtain a direct current test result.
It can be understood that, in order to ensure accurate measurement and perform multiple detections, the data processing module 4 averages a plurality of ac feedback signals to obtain a final ac feedback signal, and averages a plurality of dc feedback signals to obtain a final ac feedback signal. Of course, in addition to averaging, other processing may be performed on the original feedback signal to obtain a more effective feedback signal as the final feedback signal.
That is to say, the ac feedback signal and the dc feedback signal corresponding to the blood glucose test strip to be tested both include two parts of signals, one part is the feedback signal of the blood sample, the other part is the feedback signal of the blood glucose test strip, and the feedback signal of the blood glucose test strip is actually the interference signal that needs to be eliminated during blood glucose detection, so the data processing module 4 is specifically configured to:
when no blood sample is added to the blood glucose test paper to be detected, acquiring an alternating current background signal of an alternating current detection module and a direct current background signal of a direct current detection module;
preprocessing the AC feedback signal and the DC feedback signal according to the AC background signal and the DC background signal respectively;
and determining the blood glucose concentration according to the preprocessed alternating current feedback signal and the preprocessed direct current feedback signal.
Here, the ac background signal and the dc background signal are feedback signals of the blood glucose test strip, and the preprocessing is usually: the ac background signal is subtracted from the ac feedback signal and the dc background signal is subtracted from the dc feedback signal.
Further, the data processing module 4 calculates the blood glucose concentration of the blood sample on the blood glucose test paper to be tested according to the amplitude of the dc feedback signal, the peak value of the ac feedback signal, and other information, i.e., the above-mentioned dc test result and ac test result.
Further, the blood sugar detection system further comprises:
the temperature detection module 5 is used for detecting the current environment temperature;
the data processing module 4 is also used for performing temperature compensation on the blood glucose concentration according to the ambient temperature.
It is understood that the activity of each component in the blood sample is slightly different under different environmental temperatures, so the theoretically calculated blood glucose concentration is not accurate and needs to be calibrated through temperature compensation.
Further, the blood sugar detection system further comprises:
and the resistance detection module 6 is used for detecting the resistance value of the blood glucose test strip to be detected so as to determine whether the batch or the resistance code of the blood glucose test strip to be detected is suitable for the blood glucose detection system.
Generally, four or eight sets of resistors are built in the blood glucose test strip, and the factory information of the blood glucose test strip, such as batch and resistor code, can be known through the resistance value, and whether the blood glucose test strip can be used in the blood glucose detection system is determined.
Further, the blood sugar detection system further comprises:
the analog-to-digital conversion module 7 is used for performing analog-to-digital conversion on the alternating current feedback signal and the direct current feedback signal;
and the precision selection module 8 is used for setting the precision of the analog-to-digital conversion module 7.
It can be understood that the precision here includes 12 bits, 13 bits, 15 bits, 16 bits, etc., the Analog-to-Digital conversion module 7 is configured to have a corresponding precision through the precision selection module 8, the Analog-to-Digital conversion module 7 generally adopts a sigma-delta structure, and is specifically configured to perform Analog-to-Digital conversion on the ac feedback signal and the dc feedback signal through an oversampling ADC (Analog-to-Digital Converter), so as to eliminate environmental disturbance and system disturbance during the test process and improve the blood glucose test precision.
It will be appreciated that in addition to these modules, the blood glucose detection system may include: the blood glucose test device comprises a blood glucose test strip insertion port, a data output port, a power module for supplying power to each module, a switch module for controlling the power module, a low-voltage detection module for detecting the electric quantity of the power module and giving out a prompt when the electric quantity is low, a high-precision benchmark module for generating a reference value for signal measurement, and the high-precision benchmark module can utilize the temperature characteristics of an internal semiconductor PN junction and a resistor and fuse trimming to generate a zero temperature drift benchmark voltage of 2.048V.
Generally, the blood glucose concentration test of the blood glucose test system in this embodiment takes the state of the blood glucose test strip as a stage point: before the blood glucose test paper is not added with a blood sample, a blood glucose detection system is initialized and carries out self-checking on test environment parameters, and the action does not require the insertion of the blood glucose test paper; after the blood glucose test paper without the blood sample is inserted into the blood glucose test paper insertion hole, judging whether the blood glucose test paper is applicable or not by using the resistance detection module 6, if so, respectively obtaining an alternating current background signal and a direct current background signal, and then reminding the blood glucose test paper to add the blood sample, namely obtaining the blood glucose test paper to be detected; and detecting the blood glucose test paper to be detected, wherein the whole detection process is described above, and the blood glucose concentration is obtained and output through a data output port.
The embodiment of the invention discloses a blood sugar detection system, which comprises: the alternating current generation module is used for generating alternating current voltage with preset amplitude and preset frequency; the alternating current detection module is used for applying alternating current voltage to the blood glucose test paper to be detected to obtain an alternating current feedback signal; the direct current detection module is used for applying direct current voltage to the blood glucose test paper to be detected to obtain a direct current feedback signal; and the data processing module is used for determining the blood glucose concentration corresponding to the blood glucose test paper to be tested according to the alternating current feedback signal and the direct current feedback signal. In the embodiment of the invention, the alternating current test of the blood glucose test paper to be tested is realized by using the alternating current generation module and the alternating current detection module, and the final blood glucose concentration is determined by using two different test environments of alternating current and direct current, so that the test result is more comprehensive, the blood glucose test precision is improved, and each result is more accurate.
Correspondingly, the embodiment of the invention also discloses a blood sugar detection method, which is shown in fig. 2 and comprises the following steps:
s1: applying direct current voltage to the blood glucose test paper to be tested to obtain a direct current feedback signal;
s2: applying alternating voltage to the blood glucose test paper to be tested to obtain an alternating feedback signal;
s3: and determining the blood glucose concentration corresponding to the blood glucose test paper to be tested according to the direct current feedback signal and the alternating current feedback signal.
Because the embodiment selects two different testing environments of alternating current and direct current to determine the final blood glucose concentration, the testing result is more comprehensive, the blood glucose testing precision is improved, and each result is more accurate.
It is understood that, considering the environmental temperature influence, the blood glucose detecting method further comprises:
acquiring the current environment temperature;
and according to the ambient temperature, carrying out temperature compensation on the blood glucose concentration.
Further, the process of applying a dc voltage to the blood glucose test paper to be tested to obtain a dc feedback signal specifically includes:
applying direct-current voltage to the blood glucose test paper to be tested for multiple times to obtain a plurality of first feedback signals, and averaging the plurality of first feedback signals to obtain direct-current feedback signals;
correspondingly, the process of applying alternating voltage to the blood glucose test paper to be tested to obtain an alternating feedback signal specifically comprises the following steps:
and applying alternating voltage to the blood glucose test paper to be tested to obtain a plurality of second feedback signals, and averaging the plurality of second feedback signals to obtain alternating feedback signals.
It can be understood that, because the response object during the test of the blood glucose test strip to be tested includes two parts, namely a blood sample and the blood glucose test strip, an alternating current voltage is applied to obtain an alternating current background signal when the blood sample is not added, a direct current voltage is applied to obtain a direct current background signal, the interferences of the alternating current background signal and the direct current background signal in the alternating current feedback signal and the direct current feedback signal are respectively removed, and then the final blood glucose concentration is determined.
Finally, it should also be noted that, herein, relational terms such as first and second, and the like may be used solely to distinguish one entity or action from another entity or action without necessarily requiring or implying any actual such relationship or order between such entities or actions. Also, the terms "comprises," "comprising," or any other variation thereof, are intended to cover a non-exclusive inclusion, such that a process, method, article, or apparatus that comprises a list of elements does not include only those elements but may include other elements not expressly listed or inherent to such process, method, article, or apparatus. Without further limitation, an element defined by the phrase "comprising an … …" does not exclude the presence of other identical elements in a process, method, article, or apparatus that comprises the element.
The blood sugar detecting system and method provided by the invention are described in detail above, and the principle and the implementation mode of the invention are explained by applying specific examples, and the description of the examples is only used for helping understanding the method and the core idea of the invention; meanwhile, for a person skilled in the art, according to the idea of the present invention, there may be variations in the specific embodiments and the application scope, and in summary, the content of the present specification should not be construed as a limitation to the present invention.

Claims (10)

1. A blood glucose detection system, comprising:
the alternating current generation module is used for generating alternating current voltage with preset amplitude and preset frequency;
the alternating current detection module is used for applying the alternating current voltage to the blood glucose test paper to be detected to obtain an alternating current feedback signal;
the direct current detection module is used for applying direct current voltage to the blood glucose test paper to be detected to obtain a direct current feedback signal;
and the data processing module is used for determining the blood glucose concentration corresponding to the blood glucose test paper to be tested according to the alternating current feedback signal and the direct current feedback signal.
2. The blood glucose detection system of claim 1, further comprising:
the temperature detection module is used for detecting the current environment temperature;
the data processing module is also used for carrying out temperature compensation on the blood glucose concentration according to the environment temperature.
3. The blood glucose detection system of claim 2, wherein the data processing module is specifically configured to:
when no blood sample is added to the blood glucose test paper to be detected, acquiring an alternating current background signal of the alternating current detection module and a direct current background signal of the direct current detection module;
preprocessing the alternating current feedback signal and the direct current feedback signal according to the alternating current background signal and the direct current background signal respectively;
and determining the blood glucose concentration according to the preprocessed alternating current feedback signal and the preprocessed direct current feedback signal.
4. The blood glucose detecting system according to any one of claims 1 to 3, further comprising:
and the resistance detection module is used for detecting the resistance value of the blood glucose test strip to be detected so as to determine whether the batch or the resistance code of the blood glucose test strip to be detected is suitable for the blood glucose detection system.
5. Blood glucose test system according to claim 4, wherein the predetermined frequency is in particular 3.2 kHz.
6. The blood glucose test system of claim 5, further comprising:
the analog-to-digital conversion module is used for performing analog-to-digital conversion on the alternating current feedback signal and the direct current feedback signal;
and the precision selection module is used for setting the precision of the analog-to-digital conversion module.
7. The blood glucose detection system of claim 6, wherein the analog-to-digital conversion module is specifically configured to:
and performing analog-to-digital conversion on the alternating current feedback signal and the direct current feedback signal through an oversampling ADC.
8. A method of blood glucose testing, comprising:
applying direct current voltage to the blood glucose test paper to be tested to obtain a direct current feedback signal;
applying alternating voltage to the blood glucose test paper to be tested to obtain an alternating feedback signal;
and determining the blood glucose concentration corresponding to the blood glucose test paper to be tested according to the direct current feedback signal and the alternating current feedback signal.
9. The method of claim 8, further comprising:
acquiring the current environment temperature;
and performing temperature compensation on the blood glucose concentration according to the environment temperature.
10. The method for detecting blood glucose according to claim 9, wherein the step of applying a dc voltage to the blood glucose test strip to be detected to obtain a dc feedback signal specifically comprises:
applying direct-current voltage to the blood glucose test paper to be tested for multiple times to obtain a plurality of first feedback signals, and averaging the first feedback signals to obtain direct-current feedback signals;
correspondingly, the process of applying an alternating voltage to the blood glucose test paper to be tested to obtain an alternating feedback signal specifically comprises:
and applying alternating voltage to the blood glucose test paper to be tested to obtain a plurality of second feedback signals, and averaging the plurality of second feedback signals to obtain alternating feedback signals.
CN202010052583.8A 2020-01-17 2020-01-17 Blood sugar detection system and method Pending CN111189883A (en)

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CN105891297A (en) * 2016-05-09 2016-08-24 三诺生物传感股份有限公司 Electrochemical measurement method
CN206400016U (en) * 2016-11-03 2017-08-11 三诺生物传感股份有限公司 A kind of blood glucose meter calibrating installation
CN108872322A (en) * 2018-08-22 2018-11-23 江苏鱼跃医疗设备股份有限公司 With can automatic identification distinguish information test paper

Patent Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20040259180A1 (en) * 2003-06-20 2004-12-23 Burke David W. System and method for analyte measurement employing maximum dosing time delay
CN1839313A (en) * 2003-06-20 2006-09-27 霍夫曼-拉罗奇有限公司 Devices and methods relating to electrochemical biosensors
CN102128932A (en) * 2010-01-15 2011-07-20 泰博科技股份有限公司 Electrochemical bio-sensing test paper, biosensor device and analyte measuring system
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CN206400016U (en) * 2016-11-03 2017-08-11 三诺生物传感股份有限公司 A kind of blood glucose meter calibrating installation
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