CN111187704A - Strain drug resistance detection equipment and detection method - Google Patents
Strain drug resistance detection equipment and detection method Download PDFInfo
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- CN111187704A CN111187704A CN202010187947.3A CN202010187947A CN111187704A CN 111187704 A CN111187704 A CN 111187704A CN 202010187947 A CN202010187947 A CN 202010187947A CN 111187704 A CN111187704 A CN 111187704A
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Abstract
The invention discloses a strain drug resistance detection device and a detection method, wherein the detection device comprises a working platform, a medicament disc and a detection mounting disc are coaxially and rotatably mounted on the working platform, a plurality of groups of positioning tables are arranged on the medicament disc along the circumferential direction, three transfer devices are fixedly mounted on the working platform and are arranged along the circumferential direction of the medicament disc, a mounting groove is formed in the detection mounting disc, a threaded hole is formed in the mounting groove, and a shooting device, an inoculation device and a positioning device are fixedly mounted on the detection mounting disc through the mounting groove; the drug resistance detection equipment can automatically complete inoculation, compared with manual operation during inoculation, on one hand, batch inoculation can be performed, repeated labor is reduced, and inoculation efficiency is improved, on the other hand, the accuracy of inoculation amount and the uniformity of inoculation positions can be improved through automatic uniform inoculation, so that the inoculation effect is improved, and subsequent observation and judgment are facilitated.
Description
Technical Field
The invention belongs to the technical field of biomedical detection, and particularly relates to strain drug resistance detection equipment and a strain drug resistance detection method.
Background
The antibiotic is a chemical substance which can interfere the development function of other living cells, so that the antibiotic has good antibacterial or bactericidal effect, and the clinically common antibiotics comprise extracts in microbial culture solutions and chemically synthesized or semi-synthesized compounds;
however, since the discovery and wide application of antibacterial agents such as antibiotics, abuse is caused due to good antibacterial effect, and the abuse of antibiotics can cause the drug resistance of pathogenic bacteria and the enhancement of toxic and side effects, so that pathogenic bacteria with strong drug resistance are popular, in some scenes, the antibiotics are required to be used according to the actual drug resistance of pathogenic bacteria, the abuse of antibiotics is avoided while the efficacy of the antibiotics is ensured, therefore, in the actual operation, strains to be detected need to be collected and purified, and the drug resistance detection of the strains is carried out, the drug resistance detection process in the prior art mainly adopts manual inoculation, as the drug resistance detection process has a large amount of repeated labor, the detection efficiency is greatly reduced, and the factors such as the inoculation position and the like are easily inconsistent due to subjective factors in the repeated process, so that the judgment of the growth condition of the strains after inoculation is influenced, in addition, in the prior art, when some automatic drug resistance detection devices work, due to inaccurate positioning, the inoculation positions on the culture media are possibly not uniform during inoculation, so that the growth conditions of the strains on the culture media and the observation after the strains are cultured are influenced.
Disclosure of Invention
The invention aims to provide a strain drug resistance detection device and a strain drug resistance detection method.
The technical problems to be solved by the invention are as follows:
1. in the prior art, manual inoculation is mainly adopted, the detection efficiency is greatly reduced due to a large amount of repeated labor in the drug resistance detection process, and factors such as inoculation positions are not uniform easily due to subjective factors in the repeated process, so that the judgment of the growth condition of strains after inoculation is influenced.
2. Some automatic drug resistance detection devices in the prior art work, due to inaccurate positioning, the inoculation positions on various culture media are not uniform during inoculation, and therefore the growth conditions of strains on the culture media and observation after the strains are cultured are affected.
The purpose of the invention can be realized by the following technical scheme:
a strain drug resistance detection device comprises a working platform, wherein a medicament disc and a detection mounting disc are coaxially and rotatably mounted on the working platform, a plurality of groups of positioning platforms are arranged on the medicament disc along the circumferential direction, three transfer devices are fixedly mounted on the working platform and are arranged along the circumferential direction of the medicament disc, a mounting groove is formed in the detection mounting disc, a threaded hole is formed in the mounting groove, and a shooting device, an inoculation device and a positioning device are fixedly mounted on the detection mounting disc through the mounting groove;
the transfer device comprises a fixed table, blind holes are distributed in a rectangular array on the fixed table, a culture dish or a centrifuge tube is placed through the blind holes, a connecting plate is fixedly connected to one side of the fixed table, an air cylinder mounting table is fixed on the connecting plate, a first air cylinder and a limiting slide rod are fixedly mounted on the air cylinder mounting table, a sliding block is sleeved on the limiting slide rod and fixedly connected with one end of the first air cylinder and a second air cylinder, the second air cylinder can be driven to move in the horizontal direction through the first air cylinder, a manipulator mounting frame is fixedly connected to an air cylinder shaft of the second air cylinder, and a plurality of three-jaw manipulators are fixedly mounted on the manipulator mounting frame;
the inoculation device comprises a second mounting arm, a threaded hole is formed in the second mounting arm, the second mounting arm is fixedly connected with the mounting groove through a bolt, the inoculation device is fixedly mounted on the detection mounting disc, a fourth cylinder is fixedly mounted on the second mounting arm, a cylinder shaft of the fourth cylinder is fixedly connected with an inoculation gun mounting frame, and an inoculation gun is fixedly mounted on the inoculation gun mounting frame.
As a further scheme of the invention, the positioning device comprises a first mounting arm, a threaded hole is arranged on the first mounting arm, the first mounting arm is fixedly connected with a mounting groove through a bolt, the positioning device is fixedly mounted on a detection mounting disc, a third air cylinder is fixedly mounted on the first mounting arm, a sliding mounting plate is fixedly connected with an air cylinder shaft of the third air cylinder, the sliding mounting plate is connected with the first mounting arm in a sliding manner, a guide sliding block is connected with the sliding mounting plate in a sliding manner, a screw rod is rotatably mounted on the sliding mounting plate, the guide sliding block is sleeved on the screw rod and can drive the corresponding guide sliding block to move in the horizontal direction through rotating the screw rod, a detection mounting block is fixedly connected with one end of the guide sliding block, a mounting hole positioned above and a detection hole positioned below are arranged on the detection mounting block, and an industrial camera is fixedly mounted on the mounting, the inspection hole is arranged below the industrial camera.
As a further scheme of the invention, the sliding mounting plate is fixedly connected with a locking plate, the locking plate is sleeved on a plurality of guide sliders, the guide sliders are connected with the locking plate in a sliding manner, the locking bolts are arranged on the locking plate one by one corresponding to the guide sliders, and the positions of the guide sliders can be locked through the locking bolts.
As a further scheme of the invention, the shooting device comprises a third mounting arm, a threaded hole is formed in the third mounting arm, the third mounting arm is fixedly connected with the mounting groove through a bolt, the shooting device is fixedly mounted on the detection mounting plate, a fifth air cylinder is fixedly mounted on the third mounting arm, an industrial camera mounting frame is fixedly connected to an air cylinder shaft of the fifth air cylinder, and a plurality of industrial cameras are fixedly mounted on the industrial camera mounting frame.
The method for detecting the drug resistance of the strains by the detection equipment comprises the following steps:
step one, selecting a strain to be detected, performing streak culture on an MHA solid culture medium for 12-24 hours, then selecting a typical single colony to be transferred into a centrifuge tube containing 1mL of sterile normal saline, after shaking dispersion, placing the centrifuge tube in a blind hole of a fixed platform of a transfer device, wherein each centrifuge tube occupies one hole, then taking two holes on the fixed platform, adding the centrifuge tube with a quality control strain therein as a positive control, adding the centrifuge tube with the normal saline therein as a negative control into one blind hole on the fixed platform, thereby obtaining a strain test group to be detected, sterilizing an MH agar culture medium, cooling to 45-50 ℃, then adding an antibiotic solution into the culture medium, uniformly mixing, adding a culture dish, cooling and solidifying, and then placing on the fixed platform of another transfer device;
sequentially transferring the test groups of the strains to be detected and the culture dishes onto a medicament tray through a transfer device, acquiring sequential image information at preset time intervals by an industrial camera of the positioning device when one group of test groups of the strains to be detected or the culture dishes reaches the lower part of the positioning device, completing positioning when all the industrial cameras on the positioning device acquire a preset scene, rotating a preset angle by taking the position of the medicament tray as a starting point at the moment to enable one group of test groups of the strains to be detected or the culture dishes to reach the lower part of an inoculation device, sucking a preset amount of the strains to be detected or a control group in one group of test groups of the strains to be detected through the inoculation device, transferring the strains to the culture dishes, and then arranging the culture dishes which are completely inoculated onto a fixed platform through one transfer device;
and step three, after the plate to be detected fully absorbs the inoculation liquid, inverting the detection plate to culture for 12-24h at 37 ℃, and observing and recording the growth condition of the strains in each culture dish.
The invention has the beneficial effects that:
1. the drug resistance detection equipment can automatically complete inoculation, compared with manual operation during inoculation, on one hand, batch inoculation can be performed, repeated labor is reduced, and inoculation efficiency is improved, on the other hand, the accuracy of inoculation amount and the uniformity of inoculation positions can be improved through automatic uniform inoculation, so that the inoculation effect is improved, and subsequent observation and judgment are facilitated.
2. When the positioning device works, the positions of all the industrial cameras in the vertical direction are adjusted through the third air cylinder, the positions of the industrial cameras in the horizontal direction are adjusted through the screw rod, the positions of the industrial cameras are fixed through the locking bolts, and therefore the adjustment and the fixation of the positions of the industrial cameras are achieved.
Drawings
The invention is described in further detail below with reference to the figures and specific embodiments.
FIG. 1 is a schematic structural view of the detecting apparatus according to the present invention;
FIG. 2 is a schematic structural view of a transfer device;
FIG. 3 is a schematic view of the construction of the inoculating device;
FIG. 4 is a schematic structural diagram of the positioning device;
fig. 5 is a schematic structural diagram of the photographing apparatus.
Detailed Description
The technical solutions in the embodiments of the present invention will be clearly and completely described below, and it is obvious that the described embodiments are only a part of the embodiments of the present invention, and not all embodiments. All other embodiments, which can be derived by a person skilled in the art from the embodiments given herein without making any creative effort, shall fall within the protection scope of the present invention.
1, as shown in fig. 1 to 5, the strain drug resistance detection device comprises a working platform 1, wherein a medicament disc 2 and a detection mounting disc 3 are coaxially and rotatably mounted on the working platform 1, a plurality of groups of positioning tables 21 are circumferentially arranged on the medicament disc 2, three transfer devices 4 are fixedly mounted on the working platform 1, the three transfer devices 4 are circumferentially arranged along the medicament disc 2, a mounting groove 31 is formed in the detection mounting disc 3, threaded holes are formed in the mounting groove 31, and a shooting device 5, an inoculation device 6 and a positioning device 7 are fixedly mounted on the detection mounting disc 3 through the mounting groove 31;
the transfer device 4 comprises a fixed table 41, blind holes are distributed in a rectangular array on the fixed table 41, culture names or centrifuge tubes are placed through the blind holes, a connecting plate 42 is fixedly connected to one side of the fixed table 41, an air cylinder installation table 43 is fixed on the connecting plate 42, a first air cylinder 45 and a limiting slide rod 44 are fixedly installed on the air cylinder installation table 43, a sliding block is sleeved on the limiting slide rod 44 and fixedly connected with one end of the first air cylinder 45 and a second air cylinder 46, the second air cylinder 46 can be driven to move in the horizontal direction through the first air cylinder 45, a manipulator installation frame 47 is fixedly connected to an air cylinder shaft of the second air cylinder 46, and a plurality of three-jaw manipulators 48 are fixedly installed on the manipulator installation frame 47;
the three manipulators are respectively used for placing a culture medium, a test group of strains to be detected and a culture medium which is completely inoculated, and the transfer device 4 is used for transferring the culture medium, the test group of strains to be detected and the culture medium which is completely inoculated between the transfer device 4 and the positioning table 21;
the positioning device 7 comprises a first mounting arm 71, the first mounting arm 71 is provided with a threaded hole, the first mounting arm 71 is fixedly connected with the mounting groove 31 through a bolt, so that the positioning device 7 is fixedly mounted on the detection mounting disc 3, the first mounting arm 71 is fixedly provided with a third air cylinder 72, an air cylinder shaft of the third air cylinder 72 is fixedly connected with a sliding mounting plate 73, the sliding mounting plate 73 is slidably connected with the first mounting arm 71, the sliding mounting plate 73 is fixedly connected with a locking plate 74, the locking plate 74 is sleeved on a plurality of guide sliders 76, the guide sliders 76 are slidably connected with the locking plate 74, the guide sliders 76 are slidably connected with the sliding mounting plate 73, the sliding mounting plate 73 is rotatably provided with a lead screw 75, the guide sliders 76 are sleeved on the lead screw 75, and the corresponding guide sliders 76 can be driven to move in the horizontal direction through rotating the lead screw 75, the locking plates 74 are provided with locking bolts 77 corresponding to the guide sliders 76 one by one, and the positions of the guide sliders 76 can be locked through the locking bolts 77, so that the guide sliders 76 are prevented from deviating in work after the positions are set, and the detection results are prevented from being influenced;
one end of the guide sliding block 76 is fixedly connected with a detection mounting block 78, the detection mounting block 78 is provided with a mounting hole above and a detection hole below, an industrial camera is fixedly mounted on the mounting hole, the detection hole is arranged below the industrial camera and used for limiting the photographing range of the industrial camera, when each industrial camera acquires a preset scene, the positioning is completed, the preset scene is image information on the preset medicament tray 2, the positioning device 7 can realize the timely positioning, and the subsequent work is convenient to carry out;
the inoculation device 6 comprises a second mounting arm 61, a threaded hole is formed in the second mounting arm 61, the second mounting arm 61 is fixedly connected with the mounting groove 31 through a bolt, so that the inoculation device is fixedly mounted on the detection mounting plate 3, a fourth air cylinder 62 is fixedly mounted on the second mounting arm 61, an inoculation gun mounting frame 63 is fixedly connected to an air cylinder shaft of the fourth air cylinder 62, and an inoculation gun 64 is fixedly mounted on the inoculation gun mounting frame 63;
the shooting device 5 comprises a third mounting arm 51, a threaded hole is formed in the third mounting arm 51, the third mounting arm 51 is fixedly connected with the mounting groove 31 through a bolt, so that the shooting device is fixedly mounted on the detection mounting disc 3, a fifth air cylinder 52 is fixedly mounted on the third mounting arm 51, an industrial camera mounting frame 53 is fixedly connected to an air cylinder shaft of the fifth air cylinder 52, and a plurality of industrial cameras 54 are fixedly mounted on the industrial camera mounting frame 53.
The method for detecting the drug resistance of the strain by the equipment comprises the following steps:
step one, selecting a strain to be detected, carrying out streak culture on an MHA solid culture medium for 12-24h, then selecting a typical single colony to transfer into a centrifuge tube containing 1mL of sterile normal saline, shaking and dispersing, placing the centrifuge tube in a blind hole of a fixing table 41 of a transfer device 4, wherein each centrifuge tube occupies one hole, then taking two holes on the fixing table 41, adding the centrifuge tube containing a quality control strain into the two holes to serve as a positive control, and adding the centrifuge tube containing the normal saline into one blind hole on the fixing table 41 to serve as a negative control, so as to obtain a strain test group to be detected (comprising the strain to be detected, the positive control and the negative control); sterilizing MH agar culture medium, cooling to 45-50 deg.C, adding antibiotic solution, mixing, adding culture dish, cooling, solidifying, and placing on the fixed table 41 of another transfer device 4;
sequentially transferring the strain test groups to be tested and the culture dishes to the reagent disc 2 through the transfer device 4, collecting sequential image information at preset time intervals by an industrial camera of the positioning device 7 when a group of the strain test groups to be tested or the culture dishes to be tested reach the lower part of the positioning device 7, completing positioning when all the industrial cameras on the positioning device 7 collect preset scenes, rotating a preset angle by taking the position of the reagent disc 2 as a starting point, enabling the group of the strain test groups to be tested or the culture dishes to reach the lower part of the inoculation device 6, sucking a preset amount of the strains to be tested or the control groups in the group of the strain test groups to be tested through the inoculation device 6, transferring the strains to the culture dishes, and then arranging the culture dishes which are completely inoculated on the fixed table 41 through the transfer device 4;
and step three, after the plate to be detected fully absorbs the inoculation liquid, inverting the detection plate to culture for 12-24h at 37 ℃, and observing and recording the growth condition of the strains in each culture dish.
The drug resistance detection equipment can automatically complete inoculation, compared with manual operation during inoculation, on one hand, batch inoculation can be performed, repeated labor is reduced, the inoculation efficiency is improved, on the other hand, the accuracy of the inoculation amount and the uniformity of the inoculation position can be improved through automatic uniform inoculation, the inoculation effect is further improved, and subsequent observation and judgment are facilitated, specifically, when the positioning device 7 works, the position of each industrial camera in the vertical direction is adjusted through the third air cylinder 72, the position of each industrial camera in the horizontal direction is adjusted through the screw rod, the position of each industrial camera is fixed through the locking bolt, so that the adjustment and fixation of the position of each industrial camera are realized, when a group of strain test groups or culture dishes to be detected reach the position below the positioning device, the industrial cameras of the positioning device collect sequential image information at preset time intervals, when all industrial cameras on the positioning device collect preset scenes, positioning is completed, the position of the medicament tray is used as a starting point, a preset angle is rotated, and a group of test groups or culture dishes of the strains to be detected reach the lower part of the inoculation device, so that the adjustment and positioning can be realized, and the uniformity of the inoculation positions at each time is ensured.
The foregoing is merely exemplary and illustrative of the present invention and various modifications, additions and substitutions may be made by those skilled in the art to the specific embodiments described without departing from the scope of the invention as defined in the following claims.
Claims (5)
1. The strain drug resistance detection equipment is characterized by comprising a working platform (1), wherein a medicament disc (2) and a detection mounting disc (3) are coaxially and rotatably mounted on the working platform (1), a plurality of groups of positioning tables (21) are arranged on the medicament disc (2) along the circumferential direction, three transfer devices (4) are fixedly mounted on the working platform (1), the three transfer devices (4) are arranged along the circumferential direction of the medicament disc (2), a mounting groove (31) is formed in the detection mounting disc (3), threaded holes are formed in the mounting groove (31), and a shooting device (5), an inoculation device (6) and a positioning device (7) are fixedly mounted on the detection mounting disc (3) through the mounting groove (31);
the transfer device (4) comprises a fixed table (41), blind holes are distributed in the fixed table (41) in a rectangular array mode, a culture dish or a centrifuge tube is placed through the blind holes, a connecting plate (42) is fixedly connected to one side of the fixed table (41), a cylinder mounting table (43) is fixed to the connecting plate (42), a first cylinder (45) and a limiting slide rod (44) are fixedly mounted on the cylinder mounting table (43), a sliding block is sleeved on the limiting slide rod (44), the sliding block is fixedly connected with one end of the first cylinder (45) and a second cylinder (46), the second cylinder (46) can be driven to move in the horizontal direction through the first cylinder (45), a manipulator mounting frame (47) is fixedly connected to a cylinder shaft of the second cylinder (46), and a plurality of three-jaw manipulators (48) are fixedly mounted on the manipulator mounting frame (47);
the inoculation device (6) comprises a second mounting arm (61), a threaded hole is formed in the second mounting arm (61), the second mounting arm (61) is fixedly connected with the mounting groove (31) through a bolt, the inoculation device (6) is fixedly mounted on the detection mounting disc (3), a fourth air cylinder (62) is fixedly mounted on the second mounting arm (61), an air cylinder shaft of the fourth air cylinder (62) is fixedly connected with an inoculation gun mounting frame (63), and an inoculation gun (64) is fixedly mounted on the inoculation gun mounting frame (63).
2. The strain drug resistance detection device as claimed in claim 1, wherein the positioning device (7) comprises a first mounting arm (71), the first mounting arm (71) is provided with a threaded hole, the first mounting arm (71) is fixedly connected with the mounting groove (31) through a bolt, the positioning device (7) is fixedly mounted on the detection mounting disc (3), the first mounting arm (71) is fixedly mounted with a third cylinder (72), a cylinder shaft of the third cylinder (72) is fixedly connected with a sliding mounting plate (73), the sliding mounting plate (73) is slidably connected with the first mounting arm (71), the guide slider (76) is slidably connected with the sliding mounting plate (73), the sliding mounting plate (73) is rotatably mounted with a screw rod (75), the guide slider (76) is sleeved on the screw rod (75), and the corresponding guide slider (76) can be driven to move in the horizontal direction through rotating the screw rod (75), one end fixedly connected with of guide slider (76) detects installation piece (78), detects and is provided with the mounting hole that is in the top and the inspection hole that is in the below on installation piece (78), fixed mounting has the industry camera on the mounting hole, and the inspection hole setting is in the below of industry camera.
3. The strain drug resistance detection device according to claim 2, wherein the sliding mounting plate (73) is fixedly connected with a locking plate (74), the locking plate (74) is sleeved on a plurality of guide sliders (76), the guide sliders (76) are slidably connected with the locking plate (74), the locking bolts (77) are arranged on the locking plate (74) corresponding to the guide sliders (76), and the positions of the guide sliders (76) can be locked through the locking bolts (77).
4. The strain drug resistance detection device according to claim 1, wherein the shooting device (5) comprises a third mounting arm (51), a threaded hole is formed in the third mounting arm (51), the third mounting arm (51) is fixedly connected with the mounting groove (31) through a bolt, the shooting device (5) is fixedly mounted on the detection mounting plate (3), a fifth cylinder (52) is fixedly mounted on the third mounting arm (51), an industrial camera mounting frame (53) is fixedly connected with a cylinder shaft of the fifth cylinder (52), and a plurality of industrial cameras (54) are fixedly mounted on the industrial camera mounting frame (53).
5. The apparatus for detecting drug-resistance of a bacterial species as claimed in claim 1, wherein the method of detecting the drug-resistance of a bacterial species by the apparatus comprises:
step one, selecting a strain to be detected, carrying out streak culture on an MHA solid culture medium for 12-24h, then selecting typical single colony, transferring the typical single colony into a centrifuge tube containing 1mL of sterile physiological saline, shaking and dispersing, placing the centrifuge tubes in blind holes in a mounting table (41) of a transfer device (4), each centrifuge tube occupying a hole, then two holes are taken on a fixed platform (41) and a centrifuge tube with quality control strains is added into the holes to be used as positive control, a centrifugal tube filled with physiological saline is added into a blind hole on the fixed platform (41) as a negative control, thereby obtaining a test group of strains to be detected, sterilizing MH agar culture medium, cooling to 45-50 ℃, then adding an antibiotic solution into the mixture, uniformly mixing the antibiotic solution and the mixture, adding a culture dish into the mixture, cooling and solidifying the culture dish, and placing the culture dish on a fixed platform (41) of another transfer device (4);
step two, transferring the test group of the strains to be detected and the culture dish to a medicament tray (2) in sequence through a transfer device (4), when a group of strain test groups or culture dishes to be detected reach the lower part of the positioning device (7), the industrial camera of the positioning device (7) collects sequential image information at preset time intervals, when all the industrial cameras on the positioning device (7) acquire the preset scene, the positioning is completed, the position of the medicament tray (2) is taken as a starting point, a preset angle is rotated, a group of test groups or culture dishes of the strains to be detected reach the lower part of the inoculation device (6), absorbing a preset amount of strains to be detected or a control group in a group of test groups of strains to be detected through an inoculation device (6), transferring the strains to be detected or the control group into a culture dish, then placing the inoculated culture dish on a fixed platform (41) through a transfer device (4);
and step three, after the plate to be detected fully absorbs the inoculation liquid, inverting the detection plate to culture for 12-24h at 37 ℃, and observing and recording the growth condition of the strains in each culture dish.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202010187947.3A CN111187704A (en) | 2020-03-17 | 2020-03-17 | Strain drug resistance detection equipment and detection method |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202010187947.3A CN111187704A (en) | 2020-03-17 | 2020-03-17 | Strain drug resistance detection equipment and detection method |
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| CN111187704A true CN111187704A (en) | 2020-05-22 |
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| CN202010187947.3A Withdrawn CN111187704A (en) | 2020-03-17 | 2020-03-17 | Strain drug resistance detection equipment and detection method |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN112686857A (en) * | 2020-12-29 | 2021-04-20 | 中国科学院苏州生物医学工程技术研究所 | High-throughput multi-species colony counting method |
| CN117721005A (en) * | 2023-12-23 | 2024-03-19 | 木蕊(上海)医药科技有限公司 | Bacterial drug resistance change testing device and testing method thereof |
-
2020
- 2020-03-17 CN CN202010187947.3A patent/CN111187704A/en not_active Withdrawn
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN112686857A (en) * | 2020-12-29 | 2021-04-20 | 中国科学院苏州生物医学工程技术研究所 | High-throughput multi-species colony counting method |
| CN117721005A (en) * | 2023-12-23 | 2024-03-19 | 木蕊(上海)医药科技有限公司 | Bacterial drug resistance change testing device and testing method thereof |
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