CN111184779A - Preparation method of lung-purging granules containing semen lepidii and Chinese date - Google Patents
Preparation method of lung-purging granules containing semen lepidii and Chinese date Download PDFInfo
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Abstract
The invention relates to a preparation method of a lung-purging granule containing semen lepidii and Chinese date, in particular to a lung-purging granule containing semen lepidii and Chinese date, which is prepared from 2 raw material medicines of Chinese date and semen lepidii by the processes of pretreatment, decoction, package decoction, filtration, concentration, drying, granulation and the like, and belongs to the field of traditional Chinese medicine preparations. The obtained semen lepidii and Chinese date lung-purging granules have the effects of purging lung, promoting diuresis, descending qi and eliminating phlegm, are used for treating respiratory system diseases such as pulmonary heart disease, emphysema, exudative pleurisy, lobar pneumonia, bronchial asthma, chronic bronchitis, pertussis and the like, and have simple and special medicament efficacy and obvious effect. The traditional Chinese medicine decoction is reformed and innovated in dosage form, the problems of inconvenience in preparation, taking and carrying and the like can be effectively solved, the preparation method is scientific and reasonable, the effective substances are retained to the maximum extent, the large-scale production is easy, and the traditional Chinese medicine decoction has obvious economic benefit and application prospect.
Description
Technical Field
The invention relates to a preparation method of a pepperweed and Chinese date lung-purging granule, belonging to the field of traditional Chinese medicine preparations.
Background
The traditional Chinese medicine decoction is prepared by decoction before use, the decoction process is complicated, and the traditional Chinese medicine decoction is inconvenient to take and carry and the like, so that the urgent needs of fast-paced life style and clinical medication in modern society cannot be met. The traditional Chinese medicine granule is created from traditional Chinese medicine decoction, not only retains the characteristics of the decoction, but also overcomes the defects of temporary decoction, large dosage, poor taste, inconvenient carrying and storage, unstable quality and the like of the decoction. With the continuous application of new technology, new process, new auxiliary materials and new equipment, the Chinese medicinal granules are also greatly developed.
The semen lepidii and Chinese date lung-purging decoction is from Han Zhang Zhongjing' jin Kui Yao L ü e, has the effects of purging lung, promoting diuresis, descending qi and eliminating phlegm, is mainly used for treating pulmonary heart disease, emphysema, exudative pleuritis, lobar pneumonia bronchial asthma, chronic bronchitis, pertussis and other respiratory diseases clinically at present, and has the advantages of special drug simplicity and remarkable effect. However, the application form of decoction has many limitations, which affect the medication compliance of patients, and limit the clinical application and therapeutic effect. The research work of the traditional Chinese medicine preparation based on the semen lepidii and Chinese date lung-purging decoction does not see patent publications and literature reports at home and abroad at present. Therefore, based on the characteristics of three effects, three small and five convenient clinical medication, the development of a novel dosage form which is convenient to take and carry becomes a necessary technical problem.
Disclosure of Invention
In order to overcome the defects of the traditional decoction of the semen lepidii and Chinese date lung-purging decoction in clinical medication, the invention aims to provide a preparation method of the semen lepidii and Chinese date lung-purging granule, which can effectively solve the problem of inconvenience in preparation, administration, carrying and the like and is convenient for clinical application and full play of curative effect.
The invention relates to a preparation method of lung-purging granules containing semen lepidii and Chinese date, which comprises the following steps:
A. pretreatment process of medicinal materials
2 raw material medicinal materials of Chinese date and pepperweed seed are taken, wherein the Chinese date is cleaned and crushed, and the pepperweed seed is cleaned and fried for standby;
B. extraction process
Placing the jujubes obtained in the step A into an extraction tank I, adding 10-20 times of water, decocting for 1-2 hours, filtering to obtain liquid medicine, and transferring the liquid medicine into an extraction tank II; b, putting the fried lepidium seeds obtained in the step A into a gauze bag, tightly binding, putting into an extraction tank II, wrapping and decocting for 1-2 hours, filtering, concentrating the filtrate under reduced pressure to obtain an extract with the relative density of 1.10-1.20 at the temperature of 60-70 ℃, adding 0.3-0.6 time of dextrin by weight of the extract, uniformly stirring, and drying under reduced pressure to obtain a dry extract for later use;
C. preparation process
And C, taking the dry extract in the step B, crushing the dry extract into fine powder, adding sugar powder, dextrin and cyclodextrin, uniformly mixing, and granulating to obtain the compound.
Preferably, the weight portions of the Chinese date are 300-440, and the weight portions of the parched semen lepidii are 280-440;
preferably, the traditional Chinese medicine composition comprises the following raw materials in parts by weight: 350 parts of Chinese date and 450 parts of semen lepidii and 400 parts of semen lepidii;
the optimal weight ratio of the raw materials of the traditional Chinese medicine composition is as follows: 400 parts of Chinese date and 360 parts of semen lepidii.
Preferably, in the step B, 20 times of the total weight of the medicinal materials are added for decoction twice, the Chinese dates are decocted for 1.5 hours, and the pepperweed seeds are wrapped and decocted for 1.5 hours.
In the invention, in the step B, 20 times of the total weight of the medicinal materials are added for decoction twice, the Chinese date is decocted for 1.5 hours, and the pepperweed seed is wrapped and decocted for 1.5 hours; and C, the powdered sugar is sucrose powder or lactose powder.
Preferably, the extraction process of step B: placing the Chinese dates in the step A into an extraction tank I, adding 10-20 times of water, decocting for 1-2 hours, filtering liquid medicine, and transferring the liquid medicine into an extraction tank II; b, putting the fried semen lepidii in the step A into a gauze bag, tightly binding, putting into an extraction tank II, wrapping and decocting for 1-2 hours, filtering, concentrating the filtrate under reduced pressure to obtain an extract with the relative density of 1.15 at 65 ℃, adding 0.5 time of dextrin by weight of the extract, uniformly stirring, and drying under reduced pressure to obtain a dry extract for later use;
preferably, the powdered sugar in the step C is sucrose powder or lactose powder, and the cyclodextrin in the step C is one of β -cyclodextrin, hydroxypropyl β -cyclodextrin or gamma-cyclodextrin.
In the invention, the dry extract rate of the dried extract of the pepperweed Chinese date for purging the lung is 22.3 to 30.6 percent;
the content of quercetin-3-O- β -D-glucose-7-O- β -D-gentiobioside in the parched semen Lepidii is not less than 0.08% in terms of dry product.
The stir-fried pepperweed seed and Chinese date 2 medicinal materials related in the invention have wide resource distribution and sufficient raw material supply. The optimized granular formulation is inherited and innovated for the traditional Chinese medicine decoction, not only maintains the advantages of rapid effect and quick effect of the decoction, but also overcomes the defect of inconvenient decoction, taking and carrying when the decoction is taken, and the preparation method is scientific and reasonable, retains the drug effect substances to the maximum extent, is easy for large-scale production, and has obvious economic benefit and application prospect.
The invention relates to a medicine:
(1) parched semen Lepidii
It is a stir-fried product of Ting Li Zi, i.e. clear Ting Li Zi is stir-fried according to the clear stir-frying method (the four ministerial rules 0213 in 2015 th edition) until the sound of explosion and slight bulge appear and the surface turns brown and yellow. Semen Lepidii is dry mature seed of Descurainiae (L.) Webb. ex Prantl. belonging to Brassicaceae, and is called as "semen Lepidii Descurainiae". Meets the relevant regulations under the item of the pepperweed seed in the first part of the national pharmacopoeia 2015 edition.
Semen Lepidii mainly contains chemical components such as cardiac glycosides (such as Convolvulin, evasion glycoside, semen Lepidii glycoside, etc.), isothiocyanates (such as benzyl isothiocyanate, allyl isothiocyanate, 2-phenethyl isothiocyanate, etc.), fatty oils (such as oleic acid, linoleic acid, etc.) and sulfobutane derivatives. Semen Lepidii has various pharmacological effects of relieving cough and asthma, tonifying heart, resisting bacteria, resisting cancer, regulating blood lipid, etc., especially its cardiotonic effect can strengthen heart contraction and slow heart rate, and can increase output and reduce venous pressure for heart failure.
(2) Chinese date
The product is dried mature fruit of Ziziphus jujuba Mill of Rhamnaceae. Collected in autumn when the fruit is ripe, dried in the sun. It is sweet in taste and warm in nature, and is a common Chinese medicine for invigorating spleen and replenishing qi, nourishing blood and tranquillizing mind, and moderating drug property. Meets the relevant regulations under the item of Chinese date in the first edition of 2015 of Chinese pharmacopoeia.
The Chinese date has complex chemical components, mainly comprises triterpenic acids, saponins, alkaloids, flavonoids, polysaccharides, nucleosides and the like. Modern researches show that the Chinese date has multiple pharmacological activities, and is mainly shown in aspects of immune excitation, oxidation resistance, liver protection, lipid reduction, tumor resistance and the like. In particular, cAMP is an important physiological active substance in human body, is a mediator for intracellular transfer of hormone and transmitter, participates in regulation of various physiological and biochemical processes, can relax smooth muscle, dilate blood vessel, improve liver function, activate protein, and has significant curative effects on pulmonary heart disease, coronary heart disease, cardiogenic shock, myocardial infarction and other diseases.
The granules prepared by the invention meet or even exceed the national specified granule standard, are creative labor crystals made by scientific research, experiments and practice summarization of the applicant, and are effectively used for treating respiratory system diseases such as pulmonary heart disease, emphysema, exudative pleuritis, lobar pneumonia bronchial asthma, chronic bronchitis, pertussis and the like, and the excess syndromes of excessive phlegm and salivation, cough, asthma, fullness in chest and lung excess qi blockage are distinguished and indicated by traditional Chinese medicine.
Experimental example 1 formulation component amount screening test
Aiming at medicinal materials of semen lepidii (including fried semen lepidii) and 2 jujubes, data which clearly records clinical dosage of the medicinal materials are combed and summarized, SPSS19.0 statistical software is adopted for analysis, the dosage of the fried semen lepidii and the 2 jujubes in the semen lepidii and jujube lung-purging decoction is statistically described by means of average number, percentile, extreme difference and the like, and the statistical description is carried out by comparing with the dosage specified in 'Chinese pharmacopoeia' 2015 edition.
The related statistical data show that the minimum dosage of the fried pepperweed seed is 3.0g, and the maximum dosage is 10.0 g; the application frequency is 9.0g at most, which accounts for 62.5 percent of the whole dosage; the average dose of parched semen Lepidii is 8.4g, percentile P10 is 3.0g, and P90 is 10.0g, which indicates that the common dose range of parched semen Lepidii is about 9.0 g. The specified amount of the first part of the book of the Chinese pharmacopoeia 2015 is 3-10 g. The dosage of parched semen Lepidii 9g is determined by combining the conventional dosage range and the proportional relationship of the medicines in the prescription.
The minimum dosage of the Chinese dates is 4, and the maximum dosage of the Chinese dates is 12; the application frequency is 12 doses at most, and the application frequency accounts for 75.0 percent of the whole dosage; the average dosage of the jujubes is 10, the percentile P10 is 4, and the percentile P90 is 12, which indicates that the common dosage of the jujubes is 4-12. The specified amount of the Chinese pharmacopoeia 2015 is 6-15 g. The dosage of Chinese date is 10g determined by integrating the dosage examination of Chinese date in the prescription, the common dosage range and the proportion relation of the medicines in the prescription.
And (4) conclusion: according to the statistical result, the prescription dosage of the lung-purging granules of the pepperweed Chinese date is determined by combining the clinical dosage suggestion of doctors: parched semen Lepidii 9g and fructus Jujubae 10 g. In large-scale batch production, 900g of stir-fried semen lepidii, 1000g of Chinese date, sugar powder (sucrose powder, lactose powder and the like), dextrin, cyclodextrin and other pharmaceutic adjuvants are adopted to prepare the medicine.
Experimental example 2 selection of extraction conditions
2.1 orthogonal test factors and horizontal design
The traditional Chinese medicine meridian prescription granule follows the theory of traditional Chinese medicine, and is prepared according to the characteristics of traditional Chinese medicine decoction, the traditional Chinese medicine meridian prescription granule needs to be heated and extracted by taking water as an extraction solvent in principle, so the experiment follows that the water is used as the extraction solvent, in the decoction operation, the factors influencing the extraction effect mainly comprise the water adding quantity, the decoction time, the decoction times and the like, 3 factors of the water adding quantity (A), the decoction time (B) and the decoction times (C) and 3 levels of the factors are selected, the content and the dry extract rate of quercetin-3-O- β -D-glucose-7-O- β -D-gentiobioside in roasted lepidium seeds are used as investigation indexes, and the L content and the dry extract rate of the quercetin9(34) Orthogonal tables were designed experimentally, with the optimal leaching process being preferred. The level of each factor is designed as shown in Table 1.
TABLE 1 level table of orthogonal test factors for decoction extraction
2.2 optimized leaching process by multi-index weighting method
In each index component, the weight of the active component quercetin-3-O- β -D-glucose-7-O- β -D-gentiobioside content is 0.8 because stir-fried lepidium seed is the monarch drug in the formula, and the dry extract yield is an auxiliary investigation index, and the weight is 0.2.
The test adopts a multi-index test total probability method to analyze data, the total probability evaluation method is carried out on the 2 indexes of the content of quercetin-3-O- β -D-glucose-7-O- β -D-gentiobioside and the dry extract yield, and the two indexes are considered to be mutually incompatible,and the weights are different, and P is calculated according to the content weight of quercetin-3-O- β -D-glucose-7-O- β -D-gentiobioside, namely the weight of dry extract yield index which is 8: 2iP of 2 indicesi＝Xj/∑Xj(X is each index value, i is 1, 2, 3, j is 1, 2, 3.. 9), and the composite score P is 0.8P1+0.2P2。
Weighing 9 parts of crude drug decoction pieces (i.e. 90g of parched semen Lepidii and 100g of fructus Jujubae) in 10 times of the formula amount, placing in 5L round bottom flask, and performing 3-factor 3-level L according to factor level table9(33) Orthogonal test, adding water for decocting for a certain time, filtering with 100-mesh filter cloth or electric spinning to obtain Chinese date liquid medicine, discarding Chinese date dregs, taking fried semen lepidii, placing into a gauze bag for tightening, placing into a round-bottomed flask containing the Chinese date liquid medicine, wrapping and decocting for a certain time, filtering with 100-mesh filter cloth or electric spinning to obtain decoction, concentrating under reduced pressure to a certain volume (about 100mL) to obtain No. 1-9 leaching liquor samples, respectively measuring quercetin-3-O- β -D-glucose-7-O- β -D-gentiobioside and dry extract in the samples, carrying out comprehensive scoring on the samples, wherein the results are shown in table 2, and carrying out variance analysis on the comprehensive scoring, wherein the results are shown in table 3.
TABLE 2L9(33) Results of orthogonal experiments
TABLE 3 analysis of composite score variance
Note, F0.05(2,2)＝19，F0.01(2,2)＝99
2.3) analysis of the results
As can be seen from the visual analysis in Table 3, the optimal extraction process of the product is A3B2C3The influence degree of each factor on the comprehensive score is A>B>C, the most significant influence is the amount of water added, the time for decoction and the times for decoction.
Analysis of variance was performed on the orthogonal experiments and the results are shown in table 3. As can be seen from Table 3, the factor A has significant difference, the factor B has no significant difference from the factor C, and the important order of the influence of the factors is that the water adding amount is more than the date decocting time and more than the pepperweed seed decocting time. By combining practical requirements of production benefit ratio, energy conservation, consumption reduction and the like in large-scale production, the preferable extraction conditions are as follows: adding 20 times of water, extracting fructus Jujubae for 1.5 hr, and extracting semen Lepidii by parching for 1.5 hr.
Experimental example 3 selection of concentration, drying conditions and granulation method
The traditional Chinese medicine granules are breakthrough and innovation of traditional Chinese medicine decoction. The concentration of the extracting solution is one of the key operations of the modern Chinese medicinal preparation, and the concentration process adopts reduced pressure concentration by combining the large production condition and the economical efficiency, the practicability and the feasibility of the production operation. The method has the advantages of simple process, continuous production, low heating temperature of effective components, short time and the like. Concentrating the extracting solution to an extract with the relative density of 1.10-1.20 at the temperature of 60-70 ℃ by adopting a double-effect concentrator under the condition of vacuum degree of-0.06-0.08 Mpa, filtering (100-mesh sieve), and collecting the extract.
In consideration of the economy, the practicability and the feasibility of large-scale production operation, the belt type vacuum drying is adopted in the drying process. The inventor creatively selects medical auxiliary materials with large specific surface area and good adsorptivity, such as dextrin and cyclodextrin, as dispersing aids, namely, a certain amount of auxiliary materials such as dextrin are weighed according to the material amount of the extract in proportion, and are uniformly stirred and mixed with the extract, and then the mixture is loaded onto a belt type vacuum drying device for reduced pressure drying, so that the problems of difficult drying, time consumption and material waste are well solved.
The granulation process selects dry granulation technology, dry extract is weighed and crushed into fine powder, sugar powder (sucrose powder, lactose powder and the like) and medical auxiliary materials such as dextrin, cyclodextrin and the like are added to 1000g, and the mixture is uniformly mixed and pressed into granules, thus obtaining the product.
Drawings
FIG. 1 is a schematic view of the preparation process of the present invention.
Detailed Description
The present invention is further explained below with reference to fig. 1 by means of specific embodiments, but it should be understood by those skilled in the art that the embodiments described herein are for illustrative purposes only and do not limit the scope of the present invention in any way.
Example 1 preparation of Lung-purging granule containing semen Lepidii and fructus Jujubae
A. Pretreatment process of medicinal materials
2 raw material medicinal materials of Chinese date and pepperweed seed are taken, wherein the Chinese date is cleaned and crushed, and the pepperweed seed is cleaned and fried for standby.
B. Extraction process
Respectively weighing 5kg of Chinese dates and 2.8kg of fried semen lepidii in the step A, placing the Chinese dates in an extraction tank I, adding 10 times of water, decocting for 2 hours, filtering to obtain liquid medicine, and transferring the liquid medicine to an extraction tank II; packing the parched semen Lepidii into gauze bag, tightly binding, placing into extraction tank II, decocting for 1.5 hr, filtering, concentrating the filtrate under reduced pressure to obtain extract with relative density of 1.10 at 60-70 deg.C, adding dextrin 0.4 times the weight of the extract, stirring, and drying under reduced pressure to obtain dry extract;
C. preparation process
And C, taking the dry extract obtained in the step B, crushing into fine powder, adding 2kg of lactose powder, supplementing the weight of the lactose powder with dextrin hydroxypropyl β -cyclodextrin (1: 3) to 10kg, uniformly mixing, and granulating to obtain the lactose-lactose composite material.
Example 2 preparation of Ting Li Zi Xie Fei Keli
A. Pretreatment process of medicinal materials
2 raw material medicinal materials of Chinese date and pepperweed seed are taken, wherein the Chinese date is cleaned and crushed, and the pepperweed seed is cleaned and fried for standby.
B. Extraction process
Respectively weighing 3.5kg of Chinese dates and 4kg of fried semen lepidii in the step A, placing the Chinese dates in an extraction tank I, adding 15 times of water, decocting for 1.5 hours, filtering to obtain liquid medicine, and transferring the liquid medicine to an extraction tank II; packing the parched semen Lepidii into gauze bag, tightly binding, placing into extraction tank II, decocting for 1 hr, filtering, concentrating the filtrate under reduced pressure to obtain extract with relative density of 1.14 at 60-70 deg.C, adding dextrin 0.6 times the weight of the extract, stirring, and drying under reduced pressure to obtain dry extract;
C. preparation process
And C, taking the dry extract obtained in the step B, crushing into fine powder, adding 2kg of sucrose powder, adding 1:3 of dextrin to 10kg of dextrin, uniformly mixing, and granulating to obtain the sugar-free sucrose-containing oral liquid.
Example 3 preparation of Ting Li Zi Xie Fei Ke Li
A. Pretreatment process of medicinal materials
2 raw material medicinal materials of Chinese date and pepperweed seed are taken, wherein the Chinese date is cleaned and crushed, and the pepperweed seed is cleaned and fried for standby.
B. Extraction process
Respectively weighing 4.8kg of Chinese dates and 2.9kg of fried semen lepidii in the step A, placing the Chinese dates in an extraction tank I, adding 20 times of water, decocting for 1 hour, filtering to obtain liquid medicine, and transferring the liquid medicine to an extraction tank II; packing the parched semen Lepidii into gauze bag, tightly binding, placing into extraction tank II, decocting for 2 hr, filtering, concentrating the filtrate under reduced pressure to obtain extract with relative density of 1.12 at 60-70 deg.C, adding 0.5 times of dextrin according to the weight of extract, stirring, and drying under reduced pressure to obtain dry extract;
C. preparation process
And C, taking the dry extract obtained in the step B, crushing into fine powder, adding 1kg of sucrose powder, adding β -cyclodextrin to 1:3 of dextrin to complement the weight to 10kg, uniformly mixing, and granulating to obtain the sugar-free sucrose-containing oral liquid.
Example 4 preparation of Lung purging granule containing semen Lepidii and fructus Jujubae
A. Pretreatment process of medicinal materials
2 raw material medicinal materials of Chinese date and pepperweed seed are taken, wherein the Chinese date is cleaned and crushed, and the pepperweed seed is cleaned and fried for standby.
B. Extraction process
Respectively weighing 3.6kg of Chinese dates and 3.75kg of fried semen lepidii in the step A, placing the Chinese dates in an extraction tank I, adding 20 times of water, decocting for 2 hours, filtering to obtain liquid medicine, and transferring the liquid medicine to an extraction tank II; packing the parched semen Lepidii into gauze bag, tightly binding, placing into extraction tank II, decocting for 2 hr, filtering, concentrating the filtrate under reduced pressure to obtain extract with relative density of 1.18 at 60-70 deg.C, adding dextrin 0.3 times the weight of the extract, stirring, and drying under reduced pressure to obtain dry extract;
C. preparation process
And C, taking the dry extract obtained in the step B, crushing into fine powder, adding 3kg of lactose powder, supplementing the weight of the lactose powder with dextrin hydroxypropyl β -cyclodextrin (1: 3) to 10kg, uniformly mixing, and granulating to obtain the lactose-lactose composite material.
Example 5 preparation of Lung purging granule containing semen Lepidii and fructus Jujubae
A. Pretreatment process of medicinal materials
2 raw material medicinal materials of Chinese date and pepperweed seed are taken, wherein the Chinese date is cleaned and crushed, and the pepperweed seed is cleaned and fried for standby.
B. Extraction process
Respectively weighing 4.5kg of Chinese dates and 3.2kg of fried semen lepidii in the step A, placing the Chinese dates in an extraction tank I, adding 15 times of water, decocting for 1 hour, filtering to obtain liquid medicine, and transferring the liquid medicine to an extraction tank II; packing the parched semen Lepidii into gauze bag, tightly binding, placing into extraction tank II, decocting for 1 hr, filtering, concentrating the filtrate under reduced pressure to obtain extract with relative density of 1.17 at 60-70 deg.C, adding 0.4 times of dextrin according to the weight of extract, stirring, and drying under reduced pressure to obtain dry extract;
C. preparation process
And C, crushing the dry extract obtained in the step B into fine powder, adding 1.5kg of lactose powder, supplementing the weight of the lactose powder and hydroxypropyl gamma-cyclodextrin to 10kg of the dextrin, mixing uniformly, and granulating to obtain the finished product.
Example 6 preparation of Lung purging granule containing semen Lepidii and fructus Jujubae
A. Pretreatment process of medicinal materials
2 raw material medicinal materials of Chinese date and pepperweed seed are taken, wherein the Chinese date is cleaned and crushed, and the pepperweed seed is cleaned and fried for standby.
B. Extraction process
Respectively weighing 4kg of Chinese dates and 3.6kg of fried semen lepidii in the step A, placing the Chinese dates in an extraction tank I, adding 20 times of water, decocting for 1.5 hours, filtering to obtain liquid medicine, and transferring the liquid medicine to an extraction tank II; packing the parched semen Lepidii into gauze bag, tightly binding, placing into extraction tank II, decocting for 1.5 hr, filtering, concentrating the filtrate under reduced pressure to obtain extract with relative density of 1.15 at 60-70 deg.C, adding dextrin 0.5 times the weight of the extract, stirring, and drying under reduced pressure to obtain dry extract;
C. preparation process
And C, taking the dry extract obtained in the step B, crushing into fine powder, adding 2kg of lactose powder, supplementing the weight to 10kg with β -cyclodextrin (1: 3), mixing uniformly, and granulating to obtain the lactose-lactose milk powder.
Example 7 preparation of Lung purging granule containing semen Lepidii and fructus Jujubae
A. Pretreatment process of medicinal materials
2 raw material medicinal materials of Chinese date and pepperweed seed are taken, wherein the Chinese date is cleaned and crushed, and the pepperweed seed is cleaned and fried for standby;
B. extraction process
Respectively weighing 4.2kg of Chinese dates and 3.3kg of fried semen lepidii in the step A, placing the Chinese dates in an extraction tank I, adding 20 times of water, decocting for 2 hours, filtering to obtain liquid medicine, and transferring the liquid medicine to an extraction tank II; packing the parched semen Lepidii into gauze bag, tightly binding, placing into extraction tank II, decocting for 1 hr, filtering, concentrating the filtrate under reduced pressure to obtain extract with relative density of 1.16 at 60-70 deg.C, adding dextrin 0.3 times the weight of the extract, stirring, and drying under reduced pressure to obtain dry extract;
C. preparation process
And C, taking the dry extract obtained in the step B, crushing into fine powder, adding 2kg of sucrose powder, adding β -cyclodextrin to 1:3 of dextrin to complement the weight to 10kg, uniformly mixing, and granulating to obtain the sugar-free sucrose-containing oral liquid.
Example 8 preparation of Lung purging granule with Lepidium and Zizyphi fructus
A. Pretreatment process of medicinal materials
2 raw material medicinal materials of Chinese date and pepperweed seed are taken, wherein the Chinese date is cleaned and crushed, and the pepperweed seed is cleaned and fried for standby.
B. Extraction process
Respectively weighing 3kg of Chinese dates and 4.4kg of fried semen lepidii in the step A, placing the Chinese dates in an extraction tank I, adding 15 times of water, decocting for 1.5 hours, filtering to obtain liquid medicine, and transferring the liquid medicine to an extraction tank II; packing the parched semen Lepidii into gauze bag, tightly binding, placing into extraction tank II, decocting for 2 hr, filtering, concentrating the filtrate under reduced pressure to obtain extract with relative density of 1.11 at 60-70 deg.C, adding 0.6 times of dextrin by weight of the extract, stirring, and drying under reduced pressure to obtain dry extract;
C. preparation process
And C, taking the dry extract obtained in the step B, crushing into fine powder, adding 3kg of lactose powder, supplementing the weight of the lactose powder with dextrin hydroxypropyl β -cyclodextrin (1: 3) to 10kg, uniformly mixing, and granulating to obtain the lactose-lactose composite material.
Example 9 preparation of Ting Li Zi Xie Fei Keli
A. Pretreatment process of medicinal materials
2 raw material medicinal materials of Chinese date and pepperweed seed are taken, wherein the Chinese date is cleaned and crushed, and the pepperweed seed is cleaned and fried for standby.
B. Extraction process
Respectively weighing 3.1kg of Chinese dates and 4.2kg of fried semen lepidii in the step A, placing the Chinese dates in an extraction tank I, adding 15 times of water, decocting for 2 hours, filtering to obtain liquid medicine, and transferring the liquid medicine to an extraction tank II; packing the parched semen Lepidii into gauze bag, tightly binding, placing into extraction tank II, decocting for 1 hr, filtering, concentrating the filtrate under reduced pressure to obtain extract with relative density of 1.17 at 60-70 deg.C, adding 0.5 times of dextrin according to the weight of extract, stirring, and drying under reduced pressure to obtain dry extract;
C. preparation process
And C, taking the dry extract obtained in the step B, crushing into fine powder, adding 2kg of lactose powder, supplementing the weight of the lactose powder to 10kg by using the dextrin gamma-cyclodextrin 1:3, uniformly mixing, and granulating to obtain the lactose-lactose milk powder.
Example 10 preparation of Lung purging granule with Lepidium and Zizyphi fructus
A. Pretreatment process of medicinal materials
2 raw material medicinal materials of Chinese date and pepperweed seed are taken, wherein the Chinese date is cleaned and crushed, and the pepperweed seed is cleaned and fried for standby.
B. Extraction process
Respectively weighing 4.1kg of Chinese dates and 3.5kg of fried semen lepidii in the step A, placing the Chinese dates in an extraction tank I, adding 20 times of water, decocting for 1.5 hours, filtering to obtain liquid medicine, and transferring the liquid medicine to an extraction tank II; packing the parched semen Lepidii into gauze bag, tightly binding, placing into extraction tank II, decocting for 1.5 hr, filtering, concentrating the filtrate under reduced pressure to obtain extract with relative density of 1.11 at 60-70 deg.C, adding dextrin 0.6 times the weight of the extract, stirring, and drying under reduced pressure to obtain dry extract;
C. preparation process
And C, taking the dry extract obtained in the step B, crushing into fine powder, adding 3kg of sucrose powder, adding dextrin hydroxypropyl β -cyclodextrin (1: 3) to complement the weight to 10kg, uniformly mixing, and granulating to obtain the compound sugar-free syrup.
Claims (8)
1. A preparation method of a pepperweed and Chinese date lung-purging granule is characterized by comprising the following steps:
A. pretreatment process of medicinal materials
2 raw material medicinal materials of Chinese date and pepperweed seed are taken, wherein the Chinese date is cleaned and crushed, and the pepperweed seed is cleaned and fried for standby;
B. extraction process
Placing the jujubes obtained in the step A into an extraction tank I, adding 10-20 times of water, decocting for 1-2 hours, filtering to obtain liquid medicine, and transferring the liquid medicine into an extraction tank II; b, putting the fried lepidium seeds obtained in the step A into a gauze bag, tightly binding, putting into an extraction tank II, wrapping and decocting for 1-2 hours, filtering, concentrating the filtrate under reduced pressure to obtain an extract with the relative density of 1.10-1.20 at the temperature of 60-70 ℃, adding 0.3-0.6 time of dextrin by weight of the extract, uniformly stirring, and drying under reduced pressure to obtain a dry extract for later use;
C. preparation process
And C, taking the dry extract in the step B, crushing the dry extract into fine powder, adding sugar powder, dextrin and cyclodextrin, uniformly mixing, and granulating to obtain the compound.
2. The preparation method of claim 1, wherein the weight ratio of the raw materials of the traditional Chinese medicine composition is as follows: 300 parts of Chinese date and 440 parts of fried semen lepidii, and the like; preferably 350-450 parts of Chinese date and 320-400 parts of semen lepidii; most preferably 400 parts by weight of Chinese date and 360 parts by weight of semen lepidii.
3. The preparation method according to claim 1, wherein 20 times of the total weight of the herbs is added in step B and decocted twice, the jujube is decocted for 1.5 hours, and the pepperweed seed is wrapped and decocted for 1.5 hours.
4. The method according to claim 1, wherein the sugar powder in step C is sucrose powder or lactose powder.
5. The method of claim 1, wherein the extraction process of step B: placing the Chinese dates in the step A into an extraction tank I, adding 10-20 times of water, decocting for 1-2 hours, filtering liquid medicine, and transferring the liquid medicine into an extraction tank II; and D, filling the fried lepidium seeds in the step A into a gauze bag, tightly binding, putting into an extraction tank II, wrapping and decocting for 1-2 hours, filtering, concentrating the filtrate under reduced pressure to obtain an extract with the relative density of 1.15 at 65 ℃, adding 0.5 time of dextrin by weight of the extract, uniformly stirring, and drying under reduced pressure to obtain a dry extract for later use.
6. The method of claim 1, wherein the cyclodextrin is one of β -cyclodextrin, hydroxypropyl β -cyclodextrin, or γ -cyclodextrin.
7. The preparation method of claim 1, wherein the dry extract rate of the dried extract of semen lepidii and jujube for purging the lung is 22.3% -30.6%.
8. The parched semen Lepidii as claimed in claim 1, wherein the content of quercetin-3-O- β -D-glucose-7-O- β -D-gentiobioside in the parched semen Lepidii is not less than 0.08% in terms of dried product.
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| CN112730655A (en) * | 2020-12-18 | 2021-04-30 | 鲁南制药集团股份有限公司 | Method for establishing fingerprint of lung-purging granules of semen lepidii and Chinese date |
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| CN110393751A (en) * | 2019-08-14 | 2019-11-01 | 河南中医药大学 | Synopsis Golden Chamber side's Brassicaceae Chinese jujube Lung Soup water extract inhibits the application in esophageal cancer cell drug in preparation |
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| CN112730655A (en) * | 2020-12-18 | 2021-04-30 | 鲁南制药集团股份有限公司 | Method for establishing fingerprint of lung-purging granules of semen lepidii and Chinese date |
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