CN111184643A - Anti-yellowing preservative and preparation method thereof - Google Patents
Anti-yellowing preservative and preparation method thereof Download PDFInfo
- Publication number
- CN111184643A CN111184643A CN201911058331.XA CN201911058331A CN111184643A CN 111184643 A CN111184643 A CN 111184643A CN 201911058331 A CN201911058331 A CN 201911058331A CN 111184643 A CN111184643 A CN 111184643A
- Authority
- CN
- China
- Prior art keywords
- yellowing
- preservative
- acid
- dehydroacetic acid
- mixture
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Images
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
- A61K8/4973—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with oxygen as the only hetero atom
- A61K8/498—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with oxygen as the only hetero atom having 6-membered rings or their condensed derivatives, e.g. coumarin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/36—Carboxylic acids; Salts or anhydrides thereof
- A61K8/365—Hydroxycarboxylic acids; Ketocarboxylic acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
- A61K8/44—Aminocarboxylic acids or derivatives thereof, e.g. aminocarboxylic acids containing sulfur; Salts; Esters or N-acylated derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q5/00—Preparations for care of the hair
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/52—Stabilizers
- A61K2800/524—Preservatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/59—Mixtures
- A61K2800/592—Mixtures of compounds complementing their respective functions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/59—Mixtures
- A61K2800/592—Mixtures of compounds complementing their respective functions
- A61K2800/5922—At least two compounds being classified in the same subclass of A61K8/18
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Birds (AREA)
- Epidemiology (AREA)
- Dermatology (AREA)
- Emergency Medicine (AREA)
- Cosmetics (AREA)
Abstract
The invention relates to the field of cosmetics, and particularly relates to an anti-yellowing preservative and a preparation method thereof. The anti-yellowing preservative comprises the following components in parts by weight: 1-10 parts of dehydroacetic acid substances, 0.2-1 part of arginine, 5-10 parts of tranexamic acid and 2-5 parts of glycine. The anti-yellowing preservative has good high-temperature resistance, light yellowing resistance and good storage property; the anti-yellowing preservative has good stability and can stably exist under a weak acid condition; the anti-yellowing preservative is weakly acidic, has good mildness, and has good universality for cosmetics of various dosage forms.
Description
Technical Field
The invention relates to the field of cosmetics, and particularly relates to an anti-yellowing preservative and a preparation method thereof.
Background
In recent years, the safety problem of cosmetic preservatives has been receiving more attention, and in the conventional preservatives, parabens may cause repeated cumulative toxicity, and formaldehydes and MIT species belong to contact sensitizers, and such preservatives are being phased out as the evaluation of safety regulations is tightened.
The preservative which is in line with European Union natural organic cosmetic certification (ECOCERT) and European organic agricultural/natural cosmetic standard Certification (COSMOS) on the market mainly comprises organic acid preservatives. Dehydroacetic acid is one of organic acid preservatives, has an acidity coefficient (pKa) of about 5.30, is higher than that of benzoic acid and sorbic acid, has a wider pH application range, and has various derivatives, wherein the dehydroacetic acid is a water-soluble sodium salt of the dehydroacetic acid and is easier to use. Dehydroacetic acid and sodium salt thereof are taken as preservatives allowed to be used globally, and have the characteristics of low use cost, good mildness, good antifungal activity, high safety and the like, and have obvious advantages when being applied to foods and cosmetics.
However, dehydroacetic acid and sodium salt aqueous solutions are unstable and, even when sodium dehydroacetate is used in cosmetics at a mass fraction of 0.05%, it is very likely to yellow under high temperature and light conditions. This is because dehydroacetic acid and sodium salts are susceptible to autohydrolysis in aqueous solution to form free radicals and undergo a coupling reaction to form a by-product containing chromophores which are sensitive to uv-visible light and which are capable of absorbing uv radiation to produce a high intensity yellow color. The instability of dehydroacetic acid and sodium salt also causes the reduction of the anti-corrosion performance, the yellow intensity changes along with illumination, temperature and storage time, and the pH value is obviously yellowed within the range of 4.5-6.5. Thus, the instability of dehydroacetic acid and its sodium salt greatly limits its use in cosmetics.
For example, the chinese patent office published in 2018, 19/01 discloses a synergistic dehydroacetic acid composition and an inventive patent application for a method of reducing yellowing in various terminal compositions, with application publication No. CN201680030008, which mainly consists of dehydroacetic acid, an aprotic solvent, polyvinylpyrrolidone and an antioxidant. Meanwhile, the company Ashland introduced a preservative composition Optiphen DLP containing 92.5% propylene carbonate, 7.0% dehydroacetic acid, 0.25% butylated hydroxytoluene and 0.25% tertiary butanol, which dissolves dehydroacetic acid in an aprotic solvent to slow down the discoloration of the dehydroacetic acid in a protic solvent, but the composition is insoluble in water and can be solubilized in an aqueous product, but the addition amount is limited, the preservative property of the dehydroacetic acid is not obvious, and a small amount of the dehydroacetic acid can still cause the final product to turn yellow after being tested under high temperature and light.
For another example, the chinese patent office disclosed patent application with CN200680003170 of low PH skin care composition containing dehydroacetic acid in 2018, 01, 19, wherein dehydroacetic acid is stabilized in a skin care composition with PH not more than 4.5, but the PH of the system is too low, the mildness is difficult to be guaranteed, and the dehydroacetic acid is difficult to be widely applied to cosmetics of different dosage forms.
At present, the dehydroacetic acid preservative has few related application documents and patents, and no solution for slowing down or inhibiting yellowing of the dehydroacetic acid preservative under high temperature or illumination when the dehydroacetic acid preservative is applied to cosmetics exists in the industry.
Disclosure of Invention
In order to solve the problems that the existing preservative containing dehydroacetic acid substances is easy to yellow, particularly, the preservative is fast and obvious in yellow stain under the conditions of high temperature and/or illumination, and the problem that the preservative is easy to yellow stain in the prior art is difficult to solve, the invention provides an anti-yellowing preservative and a preparation method thereof. The purpose is as follows: firstly, providing a dehydroacetic acid preservative with good yellowing resistance; secondly, the stability of the anti-yellowing preservative is improved, so that the anti-yellowing preservative can stably exist under an acidic condition; and thirdly, the preservative is weakly acidic, and the mild and broad-spectrum antibacterial activity of the preservative is improved, so that the preservative can be widely applied to cosmetics in different dosage forms.
In order to achieve the purpose, the invention adopts the following technical scheme.
An anti-yellowing preservative, which is prepared from natural plant,
the anti-yellowing preservative comprises the following components in parts by weight: 1-10 parts of dehydroacetic acid substances, 0.2-1 part of arginine, 5-10 parts of tranexamic acid and 2-5 parts of glycine.
The components are common components in the used raw material list of the cosmetics, have high safety and multiple adaptive effects, can generate better synergistic effect through reasonable collocation and dosage control, generate better antiseptic effect and have anti-yellowing performance and multiple skin care effects. The main component mainly playing a role in corrosion prevention is dehydroacetic acid substances, and the dehydroacetic acid substances are one or a mixture of dehydroacetic acid and salt compounds thereof in any ratio. Arginine, as a basic amino acid, firstly plays a role in regulating pH, has the advantages of higher safety, less irritation, better biodegradability and the like compared with the conventional inorganic pH regulator, and can also generate certain auxiliary effects of moisturizing, moistening skin and the like after being added, and when being used for hair washing and protecting products, the arginine also has the advantages of increasing the strength, smoothness, combing property, qualitative strength and the like of hair.
The coagulonic acid is commonly used in toothpaste and clinical medicine, has the pharmacological effects of stopping bleeding and resisting inflammation, is commonly used as a skin conditioner, a humectant and a whitening agent in cosmetics, can directly inhibit the activity of melanocytes, effectively prevents melanin deposition formed by ultraviolet irradiation, and has the effect of brightening the skin.
Glycine is the simplest amino acid, and can be used as a humectant, a buffering agent and a skin conditioner, so that the skin barrier function is protected and maintained, the skin tolerance is enhanced, and the stimulation caused by the skin barrier damage is reduced.
The components are firstly matched to generate a good antiseptic effect and various care and maintenance effects on skin and hair, and on the basis, the components further generate a synergistic effect to generate a good anti-yellowing effect. The yellowing of dehydroacetic acid substances is mainly due to the fact that free radicals and tautomers are generated through photothermolysis, and a byproduct containing a chromophore is formed through a coupling reaction, the chromophore is sensitive to ultraviolet-visible light and can absorb ultraviolet ray radiation to generate high-intensity yellow, in the process, most researchers inhibit the decomposition and the formation of the free radicals by adopting an aprotic solvent, but the practical effect is limited, and when the dehydroacetic acid substances are used in cosmetics, most cosmetics inevitably contain a large amount of water which is a protic solvent, so that the effect of inhibiting the decomposition and the formation of the free radicals of the preservative component dehydroacetic acid substances by adopting the aprotic solvent is limited, and the effect is sharply reduced after the dehydroacetic acid substances are used in the cosmetics. The invention firstly adjusts the pH value to enable arginine and dehydroacetic acid substances to generate synergy, and in addition, glycine is matched to limit the generation of free radical chain reaction, thereby further inhibiting the decomposition of the dehydroacetic acid substances. On the other hand, tranexamic acid also has the effect of inhibiting decomposition of dehydroacetic acid compounds to some extent, and can inhibit the generation of a luminophore and a yellow group to some extent. The method specifically comprises the following steps: the primary amino group in tranexamic acid is more active and can generate a complex reaction with carbonyl and carboxylic acid groups of dehydroacetic acid, a chromophoric group with a conjugated structure is prevented from being generated by the tranexamic acid, the color change is avoided under the illumination condition, the molecular weight of glycine is small, the steric effect is small, the amino and carboxyl functional groups in molecules can perform an insertion reaction with a dehydroacetic acid free radical intermediate under the high-temperature condition, free radicals are quenched, the further generation of byproducts is prevented, citric acid can chelate Cu2+ and Fe3+ in water, the synergistic anticorrosion is realized, the generation of a free radical chain reaction catalyzed by metal ions is prevented, the pH value of the preservative composition is adjusted to be 5.00-5.50 by arginine and citric acid, the dehydroacetic acid is favorably and fully converted into a more stable ketonic isomer from an unstable enol form, meanwhile, the pH value of the system is in a range, the product mildness can be ensured, and the content of the undissociated dehydroacetic, the bacteriostatic property of the organic acid preservative is not affected.
Therefore, the components are indispensable and indispensable, and good synergy is generated among the components.
As a preference, the first and second liquid crystal compositions are,
the dehydroacetic acid substance is one or more of dehydroacetic acid and sodium dehydroacetate.
Dehydroacetic acid and sodium dehydroacetate are the two most commonly used and most common substances used in the dehydration of acetic acids in cosmetics, and the two can be used in combination in any ratio.
As a preference, the first and second liquid crystal compositions are,
the anti-yellowing preservative contains citric acid;
the citric acid is used for adjusting the pH value to be acidic.
The citric acid is mainly used as a pH regulator to regulate the whole preservative to be weakly acidic, so that the mildness is improved, and the alkalinity of arginine is neutralized to a certain extent on the basis of ensuring the stability of dehydroacetic acid substances.
A preparation method of an anti-yellowing preservative,
the preparation method comprises the following steps:
1) preparing materials: weighing dehydroacetic acid substances, arginine, tranexamic acid and glycine according to a ratio, and adding a solvent for mixing to obtain a pre-solution;
2) and heating and preserving the temperature of the pre-solution, cooling after preserving the temperature, and adding citric acid to adjust the pH value to subacidity to obtain the preservative.
The method is simple and efficient, and the liquid preservative can be quickly prepared by simple proportioning, heating and heat preservation, cooling after all the components are completely dissolved, and adjusting the pH value.
As a preference, the first and second liquid crystal compositions are,
during the material preparation in the step 1), the material preparation is carried out according to the proportion of 1.0-10.0 wt% of dehydroacetic acid substances, 0.2-1.0 wt% of arginine, 5.0-10.0 wt% of tranexamic acid, 2.0-5.0 wt% of glycine, 0.1-1.0 wt% of citric acid and 100 wt% of a solvent.
The solvent may be any solvent that can dissolve the above components, and is preferably a protic solvent.
As a preference, the first and second liquid crystal compositions are,
the solvent in the step 1) is water.
Water is one of the most common and most readily available protic solvents.
As a preference, the first and second liquid crystal compositions are,
step 2), heating the pre-solution to 35-55 ℃;
and 2) preserving the temperature until the solute is completely dissolved to form a uniform solution.
Too low a heating temperature may result in slow dissolution efficiency and reduced preparation efficiency, while too high a temperature may result in damage or decomposition of some components.
As a preference, the first and second liquid crystal compositions are,
and 2) adding citric acid to adjust the pH value to 5.0-5.5.
The pH value is optimal for the mild type of human body and is in an optimal pH value range.
The invention has the beneficial effects that:
1) the anti-yellowing preservative has good high-temperature resistance, light yellowing resistance and good storage property;
2) the anti-yellowing preservative has good stability and can stably exist under the weak acid condition that the pH value is 4.5-6.5;
3) the anti-yellowing preservative is weakly acidic, has good mildness, and has good universality for cosmetics of various formulations.
Drawings
FIG. 1 is a comparison of the 90D test at 25 ℃ in test 1 according to the invention;
FIG. 2 is a comparison of the illumination placement 90D test in experiment 1 of the present invention;
FIG. 3 is a comparison of the 90D test at 45 ℃ in test 1 according to the invention.
Detailed Description
The invention is described in further detail below with reference to specific embodiments and the attached drawing figures. Those skilled in the art will be able to implement the invention based on these teachings. Moreover, the embodiments of the present invention described in the following description are generally only some embodiments of the present invention, and not all embodiments. Therefore, all other embodiments obtained by a person of ordinary skill in the art based on the embodiments of the present invention without any creative effort shall fall within the protection scope of the present invention.
Unless otherwise specified, the raw materials used in the examples of the present invention are all commercially available or available to those skilled in the art; unless otherwise specified, the methods used in the examples of the present invention are all those known to those skilled in the art.
Example 1
The anti-yellowing preservative comprises the following components in the proportion shown in the following table 1.
Table 1: the dosage proportion of each component
| Dehydroacetic acid | 1.0wt％ |
| Arginine | 1.0wt％ |
| Tranexamic acid | 5.0wt％ |
| Glycine | 5.0wt％ |
| Citric acid | 0.1wt％ |
| Deionized water | to 100wt％ |
The preparation method of the composition for inhibiting dehydroacetic acid yellowing comprises the following steps: heating dehydroacetic acid, arginine, tranexamic acid, glycine and deionized water to 45 ℃, stirring and dissolving completely, cooling to normal temperature, adding citric acid to adjust the pH value to 5, and continuously stirring to obtain uniform liquid, thus obtaining the anti-yellowing preservative.
Example 2
The anti-yellowing preservative comprises the following components in the proportion shown in the following table 2.
Table 2: the dosage proportion of each component
| Sodium dehydroacetate | 10.0wt％ |
| Arginine | 0.2wt％ |
| Tranexamic acid | 10.0wt％ |
| Glycine | 3.0wt％ |
| Citric acid | 1.0wt％ |
| Deionized water | to 100wt％ |
The preparation method of the composition for inhibiting dehydroacetic acid yellowing comprises the following steps: heating dehydroacetic acid, arginine, tranexamic acid, glycine and deionized water to 45 ℃, stirring and dissolving completely, cooling to normal temperature, adding citric acid to adjust the pH value to 5.5, and continuously stirring to obtain uniform liquid, thus obtaining the anti-yellowing preservative.
Example 3
The anti-yellowing preservative comprises the following components in the proportion shown in the following table 3.
Table 3: the dosage proportion of each component
| Dehydroacetic acid | 5.0wt％ |
| Sodium dehydroacetate | 5.0wt％ |
| Arginine | 0.5wt％ |
| Tranexamic acid | 7.0wt％ |
| Glycine | 2.0wt％ |
| Citric acid | 0.2wt％ |
| Deionized water | to 100wt％ |
The preparation method of the composition for inhibiting dehydroacetic acid yellowing comprises the following steps: heating dehydroacetic acid, arginine, tranexamic acid, glycine and deionized water to 45 ℃, stirring and dissolving completely, cooling to normal temperature, adding citric acid to adjust the pH value to 5.4, and continuously stirring to obtain uniform liquid, thus obtaining the anti-yellowing preservative.
Example 4
The anti-yellowing preservative comprises the following components in the proportion shown in the following table 4.
Table 4: the dosage proportion of each component
| Dehydroacetic acid | 1.0wt％ |
| Arginine | 1.0wt％ |
| Tranexamic acid | 5.0wt％ |
| Glycine | 5.0wt％ |
| Citric acid | 0.1wt％ |
| Deionized water | to 100wt％ |
The preparation method of the composition for inhibiting dehydroacetic acid yellowing comprises the following steps: heating dehydroacetic acid, arginine, tranexamic acid, glycine and deionized water to 35 ℃, stirring and dissolving completely, cooling to normal temperature, adding citric acid to adjust the pH value to 5, and continuously stirring to obtain uniform liquid, thus obtaining the anti-yellowing preservative.
Example 5
The anti-yellowing preservative comprises the following components in the proportion shown in the following table 5.
Table 5: the dosage proportion of each component
| Dehydroacetic acid | 1.0wt％ |
| Arginine | 1.0wt％ |
| Tranexamic acid | 5.0wt％ |
| Glycine | 5.0wt％ |
| Citric acid | 0.1wt％ |
| Deionized water | to 100wt％ |
The preparation method of the composition for inhibiting dehydroacetic acid yellowing comprises the following steps: heating dehydroacetic acid, arginine, tranexamic acid, glycine and deionized water to 55 ℃, stirring and dissolving completely, cooling to normal temperature, adding citric acid to adjust the pH value to 5, and continuously stirring to obtain uniform liquid, thus obtaining the anti-yellowing preservative.
Example 6
The application of the anti-yellowing preservative comprises the following steps:
the anti-yellowing preservative is used for transparent toning lotion and comprises the following ingredients:
heating the phase A component to 70 ℃, stirring the mixture by an IKA stirrer at 400rpm until the mixture is completely dissolved, cooling the mixture to 40 ℃, adding the phase B, stirring the mixture evenly, adding a proper amount of sodium citrate to adjust the final pH value to about 5.00, cooling the mixture to room temperature, and discharging the mixture.
Example 7
The application of the anti-yellowing preservative comprises the following steps:
the anti-yellowing preservative is used for transparent toning lotion and comprises the following ingredients:
heating the phase A component to 70 ℃, stirring the mixture by an IKA stirrer at 400rpm until the mixture is completely dissolved, cooling the mixture to 40 ℃, adding the phase B, stirring the mixture evenly, adding a proper amount of sodium citrate to adjust the final pH value to about 5.00, cooling the mixture to room temperature, and discharging the mixture.
Example 8
The application of the anti-yellowing preservative comprises the following steps:
the anti-yellowing preservative is used for transparent toning lotion and comprises the following ingredients:
heating the phase A component to 70 ℃, stirring the mixture by an IKA stirrer at 400rpm until the mixture is completely dissolved, cooling the mixture to 40 ℃, adding the phase B, stirring the mixture evenly, adding a proper amount of sodium citrate to adjust the final pH value to about 5.40, cooling the mixture to room temperature, and discharging the mixture.
Comparative example 1
A transparent lotion is prepared from the following ingredients:
heating the phase A component to 70 ℃, stirring the mixture by an IKA stirrer at 400rpm until the mixture is completely dissolved, cooling the mixture to 40 ℃, adding the phase B, stirring the mixture evenly, adding a proper amount of sodium citrate to adjust the final pH value to about 5.40, cooling the mixture to room temperature, and discharging the mixture.
Comparative example 2
A transparent lotion is prepared from the following ingredients:
heating the phase A component to 70 ℃, stirring the mixture by an IKA stirrer at 400rpm until the mixture is completely dissolved, cooling the mixture to 40 ℃, adding the phase B, stirring the mixture evenly, adding a proper amount of sodium citrate to adjust the final pH value to about 5.40, cooling the mixture to room temperature, and discharging the mixture.
Comparative example 3
A transparent lotion is prepared from the following ingredients:
heating the phase A component to 70 ℃, stirring the mixture by an IKA stirrer at 400rpm until the mixture is completely dissolved, cooling the mixture to 40 ℃, adding the phase B, stirring the mixture evenly, adding a proper amount of sodium citrate to adjust the final pH value to about 5.40, cooling the mixture to room temperature, and discharging the mixture.
Comparative example 4
A transparent lotion is prepared from the following ingredients:
heating the phase A component to 70 ℃, stirring the mixture by an IKA stirrer at 400rpm until the mixture is completely dissolved, cooling the mixture to 40 ℃, adding the phase B, stirring the mixture evenly, adding a proper amount of sodium citrate to adjust the final pH value to about 5.40, cooling the mixture to room temperature, and discharging the mixture.
Comparative example 5
A transparent lotion is prepared from the following ingredients:
heating the phase A component to 70 ℃, stirring the mixture by an IKA stirrer at 400rpm until the mixture is completely dissolved, cooling the mixture to 40 ℃, adding the phase B, stirring the mixture evenly, adding a proper amount of sodium citrate to adjust the final pH value to about 5.40, cooling the mixture to room temperature, and discharging the mixture.
Test 1:
the color stability of the cosmetic is determined by observing the change of the product appearance over time under the influence of temperature and light and by accelerated experiments under different conditions.
The transparent cosmetic water prepared in comparative examples 1 to 5 and example 8 of the invention is filled in a 80mL transparent PET plastic round bottle, is respectively placed at 25 ℃ and 45 ℃ for 90D under the illumination condition, and the red, yellow, blue and neutral values of a sample measured by a Lovibond PFxi 800/F full-automatic spectrocolorimeter before and after high-temperature and illumination acceleration experiments are smaller in color change, which shows that the composition of the invention has more obvious effect of inhibiting dehydroacetic acid or sodium salt thereof from yellowing, and the chromaticity test result is shown in Table 6.
Wherein, comparative example 1 is transparent toning lotion without dehydroacetic acid and sodium salt preservative thereof, which is used as a blank control group, comparative example 2 is transparent toning lotion containing 0.1 percent of dehydroacetic acid and 0.1 percent of sodium dehydroacetate preservative, comparative examples 3 to 5 are transparent toning lotions which lack synergistic components respectively, which is used as a control group, example 8 is transparent toning lotion containing anti-yellowing preservative, and dehydroacetic acid substances dehydroacetic acid and/or sodium dehydroacetate with the same addition amount as that of the comparative examples 2 to 5 are used.
The results are shown in Table 6 below:
table 6: test 1 test results
As is apparent from Table 6 above, when the transparent lotions prepared in comparative examples 1 and 8 were examined at 45 ℃ and under accelerated illumination for 90D, the red, yellow and blue values did not change significantly, while when the transparent lotions prepared in comparative examples 2 to 5 were examined for 90D under different conditions, the red and yellow values increased, and particularly, the yellow value changed most significantly after standing at 45 ℃ for 90D, and the yellowing was most significant. Wherein: comparative example 1, comparative example 2 and example 8 transparent lotions after standing at 25 ℃ for 90D are shown in fig. 1 from left to right in sequence; comparative example 1, comparative example 2 and example 8 transparent lotions after standing in the light for 90D are shown in fig. 2 from left to right in sequence; comparative example 1, comparative example 2 and example 8 transparent lotions after standing at 45 ℃ for 90D are shown in fig. 3 from left to right in this order. It is also apparent from the figure that the addition of the anti-yellowing preservative of the invention can produce a good anti-yellowing effect. Therefore, a transparent cosmetic applicator containing the anti-yellowing preservative can have a good anti-yellowing effect under the conditions of high temperature or illumination, is applied to a transparent aqueous product, has good color stability, and prolongs the shelf life of cosmetics.
Test 2:
cosmetic preservation challenge test experiments are an effective method for evaluating the bacteriostatic performance of preservatives. At present, cosmetic anticorrosion challenge test experimental methods mainly refer to the United statesAnd (3) according to the pharmacopoeia USP, quantitatively inoculating the cosmetics once, regularly observing and calculating the total number of microbial colonies within 28 days, and judging the bacteriostatic performance of the preservative of the cosmetics. The inoculated microorganisms are Staphylococcus aureus (ATCC6538), Escherichia coli (ATCC8739), Pseudomonas aeruginosa (ATCC9027), Candida albicans (ATCC10231) and Aspergillus niger (ATCC16404), wherein the concentration of the bacteria inoculated is 1.0 × 106CFU/g, inoculation concentration of fungi 1.0 × 105CFU/g, and the number of survivors of each bacterium was examined on days 7, 14, and 28, respectively, with the lower number of survivors indicating the better antibacterial effect of the preservative.
The evaluation criteria were that the total number of mixed bacteria (ATCC6538, ATCC8739, ATCC9027) and fungi (CATCC10231, ATCC16404) were reduced by a logarithmic value of not less than 3.0 from the initial to 14 days of counting, and were not detected by 28 days.
The transparent lotions prepared in example 8 of the present invention and comparative example 2 were subjected to the preservation challenge test with reference to the above-mentioned methods, and the results are shown in Table 7.
TABLE 7 Corrosion protection challenge test results for two sets of clear lotions
As can be seen from table 7, under the condition of the same addition amount of the preservative, the transparent lotion prepared in example 8 has more efficient preservative performance, and especially has more outstanding bacteriostatic performance on fungi in 14D, so that the yellowing-resistant preservative applied to the cosmetics has no adverse effect on the preservative performance, and on the contrary, the rest components in the composition can further synergize the preservative bacteriostatic performance.
Claims (8)
1. An anti-yellowing preservative is characterized in that,
the anti-yellowing preservative comprises the following components in parts by weight: 1-10 parts of dehydroacetic acid substances, 0.2-1 part of arginine, 5-10 parts of tranexamic acid and 2-5 parts of glycine.
2. The anti-yellowing preservative according to claim 1,
the dehydroacetic acid substance is one or more of dehydroacetic acid and sodium dehydroacetate.
3. The anti-yellowing preservative according to claim 1 or 2,
the anti-yellowing preservative contains citric acid;
the citric acid is used for adjusting the pH value to be acidic.
4. A process for the preparation of the anti-yellowing preservative according to claim 1, 2 or 3,
the preparation method comprises the following steps:
1) preparing materials: weighing dehydroacetic acid substances, arginine, tranexamic acid and glycine according to a ratio, and adding a solvent for mixing to obtain a pre-solution;
2) and heating and preserving the temperature of the pre-solution, cooling after preserving the temperature, and adding citric acid to adjust the pH value to subacidity to obtain the preservative.
5. The method for preparing anti-yellowing preservative according to claim 4,
during the material preparation in the step 1), the material preparation is carried out according to the proportion of 1.0-10.0 wt% of dehydroacetic acid substances, 0.2-1.0 wt% of arginine, 5.0-10.0 wt% of tranexamic acid, 2.0-5.0 wt% of glycine, 0.1-1.0 wt% of citric acid and 100 wt% of a solvent.
6. The method for preparing anti-yellowing preservative according to claim 4 or 5,
the solvent in the step 1) is water.
7. The method for preparing anti-yellowing preservative according to claim 4,
step 2), heating the pre-solution to 35-55 ℃;
and 2) preserving the temperature until the solute is completely dissolved to form a uniform solution.
8. The method for preparing anti-yellowing preservative according to claim 4,
and 2) adding citric acid to adjust the pH value to 5.0-5.5.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201911058331.XA CN111184643A (en) | 2019-11-01 | 2019-11-01 | Anti-yellowing preservative and preparation method thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201911058331.XA CN111184643A (en) | 2019-11-01 | 2019-11-01 | Anti-yellowing preservative and preparation method thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN111184643A true CN111184643A (en) | 2020-05-22 |
Family
ID=70684356
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201911058331.XA Pending CN111184643A (en) | 2019-11-01 | 2019-11-01 | Anti-yellowing preservative and preparation method thereof |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN111184643A (en) |
Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101321557A (en) * | 2005-11-30 | 2008-12-10 | 宝洁公司 | Personal care composition comprising dehydroacetate salts |
| CN102599613A (en) * | 2011-12-03 | 2012-07-25 | 天津北洋百川生物技术有限公司 | Selection and application of compound antiseptic |
| CN107613954A (en) * | 2015-03-26 | 2018-01-19 | Isp投资有限公司 | The cooperative compositions of dehydroactic acid and the method for reducing the xanthochromia in various terminals composition |
| RU2017123744A (en) * | 2017-07-05 | 2019-01-09 | Общество с ограниченной ответственностью "НАТУРА СИБЕРИКА" (сокращенно ООО "НАТУРА СИБЕРИКА") | Cosmetic composition against hair loss and stimulating hair growth |
| CN109925207A (en) * | 2019-01-02 | 2019-06-25 | 杭州犇鑫科技有限公司 | A kind of new food preservative composition and its preparation method and application |
-
2019
- 2019-11-01 CN CN201911058331.XA patent/CN111184643A/en active Pending
Patent Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101321557A (en) * | 2005-11-30 | 2008-12-10 | 宝洁公司 | Personal care composition comprising dehydroacetate salts |
| CN102599613A (en) * | 2011-12-03 | 2012-07-25 | 天津北洋百川生物技术有限公司 | Selection and application of compound antiseptic |
| CN107613954A (en) * | 2015-03-26 | 2018-01-19 | Isp投资有限公司 | The cooperative compositions of dehydroactic acid and the method for reducing the xanthochromia in various terminals composition |
| RU2017123744A (en) * | 2017-07-05 | 2019-01-09 | Общество с ограниченной ответственностью "НАТУРА СИБЕРИКА" (сокращенно ООО "НАТУРА СИБЕРИКА") | Cosmetic composition against hair loss and stimulating hair growth |
| CN109925207A (en) * | 2019-01-02 | 2019-06-25 | 杭州犇鑫科技有限公司 | A kind of new food preservative composition and its preparation method and application |
Non-Patent Citations (2)
| Title |
|---|
| 孔秋婵等: "p-茴香酸、乙酰丙酸钠与脱氢乙酸钠的复配物在化妆品中的应用研究", 《香料香精化妆品》 * |
| 陈玲玲等: "甘氨酸和防腐剂复配使用的抑菌效果", 《食品科技》 * |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| US4891216A (en) | Disinfecting compositions and methods therefor | |
| JP4014114B2 (en) | Antibacterial action enhancer | |
| EP0350275B1 (en) | Preservative composition for wet wipes | |
| US20060093634A1 (en) | Personal care compositions and concentrates for making the same | |
| CN110292045B (en) | Preparation method and application of antimicrobial composition containing epsilon-polylysine | |
| US3950554A (en) | Treatment of mastitis in bovine udders | |
| CN110215404B (en) | Liquid cymene and preparation method and application thereof | |
| CA2850908A1 (en) | Aqueous antimicrobial composition containing coniferous resin acids | |
| DE60219460T2 (en) | ALCOHOL-FREE LIQUID CONCENTRATE FOR PRESERVING COSMETIC, HOUSEHOLD AND TECHNICAL PRODUCTS | |
| EP2664318B1 (en) | Antimicrobially active compositions based on zinc compound, glycerine monoalkyl ether and antioxidant | |
| KR102059043B1 (en) | Antiseptic Composition | |
| CN111184643A (en) | Anti-yellowing preservative and preparation method thereof | |
| CN112755050A (en) | Alcohol-free iodine-containing disinfectant with high component stability and preparation method thereof | |
| CN112675104A (en) | Skin-care disinfecting gel and preparation method thereof | |
| CN107280992A (en) | Waterborne-type preservation composition containing natamycin and preparation method and application | |
| CN110917057A (en) | Compound preservative agent, preparation method thereof and application thereof in cosmetics | |
| KR20200108377A (en) | Antiseptic Composition and wet wipes comprising the same | |
| US9907737B2 (en) | Composition comprising ferulic acid ethyl ester and aryl alkanol | |
| EP3648734A1 (en) | Topical compositions | |
| DE2338462C3 (en) | ||
| CN114053162B (en) | Color-stable preservative composition containing sorbic acid and application thereof | |
| CN114533809B (en) | Vitamin E antibacterial cream and preparation method thereof | |
| RU2787381C1 (en) | Cream for milking | |
| CN115812742A (en) | Antibacterial composition containing lysozyme and zinc hyaluronate and application thereof | |
| CN115350203A (en) | Antibacterial composition and application thereof |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| RJ01 | Rejection of invention patent application after publication | ||
| RJ01 | Rejection of invention patent application after publication |
Application publication date: 20200522 |