CN111177117B - Data processing method for traditional Chinese medicine medical records - Google Patents
Data processing method for traditional Chinese medicine medical records Download PDFInfo
- Publication number
- CN111177117B CN111177117B CN201911297599.9A CN201911297599A CN111177117B CN 111177117 B CN111177117 B CN 111177117B CN 201911297599 A CN201911297599 A CN 201911297599A CN 111177117 B CN111177117 B CN 111177117B
- Authority
- CN
- China
- Prior art keywords
- database
- traditional chinese
- medicinal material
- medical
- formula
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
Images
Classifications
-
- G—PHYSICS
- G06—COMPUTING; CALCULATING OR COUNTING
- G06F—ELECTRIC DIGITAL DATA PROCESSING
- G06F16/00—Information retrieval; Database structures therefor; File system structures therefor
- G06F16/20—Information retrieval; Database structures therefor; File system structures therefor of structured data, e.g. relational data
- G06F16/21—Design, administration or maintenance of databases
-
- G—PHYSICS
- G06—COMPUTING; CALCULATING OR COUNTING
- G06F—ELECTRIC DIGITAL DATA PROCESSING
- G06F16/00—Information retrieval; Database structures therefor; File system structures therefor
- G06F16/20—Information retrieval; Database structures therefor; File system structures therefor of structured data, e.g. relational data
- G06F16/24—Querying
- G06F16/245—Query processing
- G06F16/2455—Query execution
-
- G—PHYSICS
- G06—COMPUTING; CALCULATING OR COUNTING
- G06F—ELECTRIC DIGITAL DATA PROCESSING
- G06F16/00—Information retrieval; Database structures therefor; File system structures therefor
- G06F16/20—Information retrieval; Database structures therefor; File system structures therefor of structured data, e.g. relational data
- G06F16/25—Integrating or interfacing systems involving database management systems
-
- G—PHYSICS
- G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
- G16H—HEALTHCARE INFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR THE HANDLING OR PROCESSING OF MEDICAL OR HEALTHCARE DATA
- G16H70/00—ICT specially adapted for the handling or processing of medical references
- G16H70/40—ICT specially adapted for the handling or processing of medical references relating to drugs, e.g. their side effects or intended usage
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A90/00—Technologies having an indirect contribution to adaptation to climate change
- Y02A90/10—Information and communication technologies [ICT] supporting adaptation to climate change, e.g. for weather forecasting or climate simulation
Landscapes
- Engineering & Computer Science (AREA)
- Theoretical Computer Science (AREA)
- Databases & Information Systems (AREA)
- Data Mining & Analysis (AREA)
- Physics & Mathematics (AREA)
- General Engineering & Computer Science (AREA)
- General Physics & Mathematics (AREA)
- Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Toxicology (AREA)
- Epidemiology (AREA)
- General Health & Medical Sciences (AREA)
- Medical Informatics (AREA)
- Primary Health Care (AREA)
- Public Health (AREA)
- Computational Linguistics (AREA)
- Medical Treatment And Welfare Office Work (AREA)
Abstract
The invention discloses a data processing method of a traditional Chinese medicine case, which relates to the technical field of medical treatment, and the technical scheme is that the information of the traditional Chinese medicine case and the information of the traditional Chinese medicine are respectively dataized; establishing a medical case database; establishing a traditional Chinese medicine database; carrying out data association on the medical table database and the traditional Chinese medicine database; integrating the data into an integrated traditional Chinese medicine treatment database according to the associated data, and configuring an external interface; the user selects multidimensional data information according to the traditional Chinese medicine treatment database and sends a query request; and searching according to the query request and integrating and outputting the search result. The beneficial effects of the invention are as follows: the method can conveniently inquire and manage the existing medical formula and the use scheme of the traditional Chinese medicine which is provided in the medical scheme but has differences with the existing formula. And the output results can be searched in a correlated way during treatment, so that effective references are provided for the treatment process.
Description
Technical Field
The invention relates to the technical field of medical treatment, in particular to a data processing method of a traditional Chinese medicine case.
Background
The Chinese medicine medical records, also called diagnosis, pulse, plan and medical records, are the records of the characters of the doctors of Chinese medicine for diagnosis and treatment, and are the archival data for the preservation, examination, evaluation and even research of specific diagnosis and treatment activities. Along with the inheritance and development of traditional Chinese medicine, the traditional Chinese medicine case is gradually changed and perfected from the exterior to the interior.
With the development of computer technology, the research of electronic medical records is also vigorously developed through the realization of a hospital information management system, and the "basic functional Specification of a hospital information system" is promulgated in 2002. The hospitals have mostly established HIS systems and further realized the collection and arrangement of massive medical records. Under the application of database and data mining technology, precious and inexhaustible information left by traditional Chinese medicine is gradually and effectively mined and utilized.
The traditional Chinese medicine medical proposal is mainly text data, and in the early traditional Chinese medicine data mining research, a great deal of effort is consumed in the processes of collecting, storing and inquiring data due to the lack of support of a database. With the development and improvement of traditional Chinese medicine database technology, various traditional Chinese medicine case management systems appear, and the problems are solved. However, there are still problems to be solved during the research:
(1) implementation of various algorithms requires preprocessing of medical case data to convert the text data into identifiable codes.
(2) The statistics of various multidimensional data are needed by various statistical software such as SAS, SPSS and the like, and how to derive applicable data formats is also a problem to be solved
Aiming at the problems, part of researches are solved by a mode of self-building a standard database, such as a symptom library name database, a evidence name database, a diagnosis name database and the like, and the medical record is required to select the existing data in the database. The method converts the text medical case into a standard data form, and the data preprocessing process is simplified, but excessive formatting can lose the text characteristics of the traditional Chinese medical case, so that the recorded medical case has excessive subjectivity, and is not beneficial to the preservation and inheritance of the traditional Chinese medical case.
Disclosure of Invention
Aiming at the technical problems, the invention provides a traditional Chinese medicine case data processing method.
The technical proposal is that,
s1, respectively dataing medical cases and information of traditional Chinese medicinal materials;
s2, establishing a medical case database;
s3, establishing a traditional Chinese medicine database;
s4, carrying out data association on the medical case database of the S2 and the Chinese medicinal material database of the S3;
s5, integrating the data associated with the step S4 into an integrated traditional Chinese medicine treatment database, and configuring an external interface;
s6, selecting multidimensional data information according to the traditional Chinese medicine treatment database by a user, and sending a query request;
and S7, searching according to the request of S6 and integrating and outputting the search result.
Preferably, the method for establishing the S2 medical records database comprises the steps of,
s201, defining a multi-dimensional medical case data element structure according to the medical case data of the S1;
s202, splitting elements of the medical case which is obtained by the step S1 according to the medical case data element structure of the step S201;
s203, integrating the multidimensional data element structure of S201 and the medical case data split in S202 into the medical case database.
Preferably, the method for establishing the database of the S3 Chinese medicinal materials comprises the following steps of,
s301, defining a multidimensional medicinal material data element structure according to the information of the Chinese medicinal materials in the S1;
s302, carrying out element splitting on the traditional Chinese medicine information which is obtained by the data processing of the S1 according to the element structure of the medicinal material data of the S301;
s303, setting unique codes for each Chinese medicinal material;
s304, integrating the medicinal material data element structure of S301, the split Chinese medicinal material data of S302 and the codes of S303 into the Chinese medicinal material basic database;
s305, combining the medicinal material basic database of the S304, combining medicinal material elements in the traditional Chinese medicinal material basic database of the traditional Chinese medicine formula, and generating a formula basic database;
s306, associating medicinal material elements in the medicinal material basic database and the formula basic database, and configuring an updating interface;
s307, generating the traditional Chinese medicine database according to the data of S305.
Preferably, in S305, the medicinal material basic database of S304 is combined with medicinal material elements in the traditional Chinese medicinal material basic database of the existing traditional Chinese medicine formula combination, and a formula basic database is generated, wherein the method comprises the steps of sorting medicinal material elements in the formula, combining the sorted Chinese medicinal material formula combination according to the Chinese medicinal material codes set in S303, and combining the Chinese medicinal material codes to generate a basic formula code string.
Preferably, in the step S4, the data association method is that the medical case database of the step S2 and the Chinese medicinal material database of the step S3 are carried out,
s401, splitting formula elements of the medical case database, and splitting a treatment formula in the medical case database into single medicinal material elements;
s402, sorting the split medicinal material names in the S401 according to pinyin;
s403, sequencing the prescription medicinal materials in S402, and generating a treatment prescription coding character string according to the unique codes of the 303 Chinese medicinal materials.
Preferably, in the step S5, the external query interface of the traditional Chinese medicine treatment database is a binary query option interface corresponding to the element composition.
Preferably, in the step S7, the search is performed according to the request of the step S6, and the search result is integrated and output specifically,
inquiring corresponding medical cases in a medical case database according to information selected by a user, traversing basic formula coding character strings in the formula basic database according to treatment formula coding character strings of the corresponding medical cases in S403, comparing similarity of the two character strings, and selecting a plurality of formulas with higher similarity ranking in the formula basic database as associated formulas of the corresponding medical cases in the medical case database;
integrating and outputting the medical case data corresponding to the medical case in the medical case database and the associated formula of the medical case corresponding to the basic formula database.
The technical scheme provided by the embodiment of the invention has the beneficial effects that: the method can conveniently inquire and manage the existing medical formula and the use scheme of the traditional Chinese medicine which is provided in the medical scheme but has differences with the existing formula. And the output results can be searched in a correlated way during treatment, so that effective references are provided for the treatment process.
Drawings
FIG. 1 is a flow chart of a method according to an embodiment of the invention.
Detailed Description
The present invention will be described in further detail with reference to the drawings and examples, in order to make the objects, technical solutions and advantages of the present invention more apparent. Of course, the specific embodiments described herein are for purposes of illustration only and are not intended to limit the invention.
It should be noted that, without conflict, the embodiments of the present invention and features of the embodiments may be combined with each other.
Example 1
Referring to fig. 1, the invention provides a data processing method of a traditional Chinese medicine medical case, wherein, S1, medical case and traditional Chinese medicine information are respectively dataized;
s2, establishing a medical case database;
the establishing method of the medical records database S2 comprises,
s201, defining a multi-dimensional medical case data element structure according to medical case data of S1; the multidimensional elements of the medical proposal can be decomposed in a diagnosis mode, such as ' looking ', ' smelling ', ' asking ', ' cutting ', ' symptom type ', ' treating method ', ' doctor ' and advice ', and the like, such as ' chest obstruction ' in ' asking ' and ' blood stasis ' in ' symptom type ', and the like.
S202, splitting elements of the medical case of the S1 datamation according to the medical case data element structure of the S201;
s203, integrating the multidimensional data element structure of S201 and the medical case data split in S202 into a medical case database.
S3, establishing a traditional Chinese medicine database;
the method for establishing the database of the traditional Chinese medicinal materials is as follows,
s301, defining a multidimensional medicinal material data element structure according to the information of the Chinese medicinal materials in the S1; most of the traditional Chinese medicinal materials are elements, and can be divided and sorted according to the names and different attributes of the medicines;
s302, carrying out element splitting on the traditional Chinese medicine information which is obtained by the data of the S1 according to the element structure of the medicinal material data of the S301;
s303, setting unique codes for each Chinese medicinal material; the unique codes of the Chinese medicinal materials can be character strings formed by splicing zone bit codes of Chinese medicinal material names; because the region bit code is one code for each word, the accuracy is higher in the later retrieval process. Other coding forms can be selected, and the principle is that the character strings are obviously distinguished in the subsequent steps.
S304, integrating the medicinal material data element structure of S301, the split Chinese medicinal material data of S302 and the codes of S303 into a Chinese medicinal material basic database;
s305, combining the medicinal material basic database of the S304, combining medicinal material elements in the traditional Chinese medicinal material basic database of the traditional Chinese medicine formula, and generating a formula basic database;
in S305, the medicinal material basic database of S304 is combined with the medicinal material elements in the traditional Chinese medicine basic database of the traditional Chinese medicine formula combination, and a formula basic database is generated, wherein the sorting method can sort the medicinal material elements in the formula according to the pinyin of the name of the medicinal material, or other sorting methods, the sorted Chinese medicine formula combination is combined according to the Chinese medicine codes set in S303, and the Chinese medicine codes are combined to generate a basic formula code string.
S306, associating medicinal material elements in the medicinal material basic database and the formula basic database, and configuring an updating interface;
s307, generating a traditional Chinese medicine database according to the data of S305.
S4, carrying out data association on the medical case database of the S2 and the Chinese medicinal material database of the S3;
in S4, the data association method of the medical case database of S2 and the Chinese medicinal material database of S3 is that,
s401, splitting formula elements of a medical case database, and splitting a treatment formula in the medical case database into single medicinal material elements;
s402, sorting the split medicinal material names in the S401 according to pinyin;
s403, the prescription medicinal materials sequenced in S402 are uniquely coded according to 303 Chinese medicinal materials to generate a therapeutic prescription coding character string.
S5, integrating the data associated with the step S4 into an integrated traditional Chinese medicine treatment database, and configuring an external interface;
s5, the external query interface of the traditional Chinese medicine treatment database is a two-class query option interface formed by corresponding elements; that is, its corresponding query option is the "yes" or "no" option for the disorder.
S6, selecting multidimensional data information according to the traditional Chinese medicine treatment database by a user, and sending a query request;
s7, searching according to the request of S6 and integrating and outputting the search result; s7, searching according to the request of S6 and integrating and outputting the searching result,
inquiring corresponding medical cases in a medical case database according to the information selected by the user, traversing basic formula coding character strings in a formula basic database according to the treatment formula coding character strings of the corresponding medical cases in S403, comparing the similarity of the two character strings, and selecting a plurality of formulas with higher similarity ranking in the formula basic database as associated formulas of the corresponding medical cases in the medical case database;
the similarity judging method is that two character strings are initially compared, the more similar characters appear, the higher the similarity, and according to the result obtained by the initial comparison, the higher the similarity is if the sequence similarity of the positions of the similar characters is, the higher the similarity is.
Integrating and outputting the medical case data corresponding to the medical case in the medical case database and the associated formula of the medical case corresponding to the basic formula database.
When the diagnosis device is specifically used, a doctor diagnoses a patient, sets corresponding query parameters on the query interface according to the state of the patient, and obtains a final result through query after the setting is completed. The therapeutic effect can be known by comparing the therapeutic formula with the base formula in the medical regimen, and the therapeutic reference can be known if the doctor adds or subtracts a certain drug in the therapeutic formula in the medical regimen.
The foregoing is only illustrative of the present invention and is not to be construed as limiting thereof, but rather as various modifications, equivalent arrangements, improvements, etc., within the spirit and principles of the present invention.
Claims (3)
1. A data processing method of traditional Chinese medicine cases is characterized in that,
s1, respectively dataing medical cases and information of traditional Chinese medicinal materials;
s2, establishing a medical case database;
s3, establishing a traditional Chinese medicine database;
s4, carrying out data association on the medical case database of the S2 and the Chinese medicinal material database of the S3;
s5, integrating the data associated with the step S4 into an integrated traditional Chinese medicine treatment database, and configuring an external interface;
s6, selecting multidimensional data information according to the traditional Chinese medicine treatment database by a user, and sending a query request;
s7, searching according to the request of S6 and integrating and outputting the search result;
wherein, the establishing method of the S2 medical records database is that,
s201, defining a multi-dimensional medical case data element structure according to the medical case data of the S1;
s202, splitting elements of the medical case which is obtained by the step S1 according to the medical case data element structure of the step S201;
s203, integrating the multidimensional data element structure of S201 and the medical case data split in S202 into the medical case database;
wherein the method for establishing the database of the S3 traditional Chinese medicinal materials comprises the following steps of,
s301, defining a multidimensional medicinal material data element structure according to the information of the Chinese medicinal materials in the S1;
s302, carrying out element splitting on the traditional Chinese medicine information which is obtained by the data processing of the S1 according to the element structure of the medicinal material data of the S301;
s303, setting unique codes for each Chinese medicinal material;
s304, integrating the medicinal material data element structure of S301, the split Chinese medicinal material data of S302 and the codes of S303 into the Chinese medicinal material basic database;
s305, combining the medicinal material basic database of the S304, combining medicinal material elements in the traditional Chinese medicinal material basic database of the traditional Chinese medicine formula, and generating a formula basic database;
s306, associating medicinal material elements in the medicinal material basic database and the formula basic database, and configuring an updating interface;
s307, generating the traditional Chinese medicine database according to the data of the S305;
wherein, in the step S4, the data association method is that the medical case database of the step S2 and the Chinese medicinal material database of the step S3 are carried out,
s401, splitting formula elements of the medical case database, and splitting a treatment formula in the medical case database into single medicinal material elements;
s402, sorting the split medicinal material names in the S401 according to pinyin;
s403, sequencing the prescription medicinal materials in the S402, and generating a treatment prescription coding character string according to the unique codes of the traditional Chinese medicinal materials in the S303;
wherein, the retrieval is carried out according to the request of S6 and the retrieval result is integrated and output specifically,
inquiring corresponding medical cases in a medical case database according to information selected by a user, traversing basic formula coding character strings in the formula basic database according to treatment formula coding character strings of the corresponding medical cases in S403, comparing similarity of the two character strings, and selecting a plurality of formulas with higher similarity ranking in the formula basic database as associated formulas of the corresponding medical cases in the medical case database;
integrating and outputting the medical case data corresponding to the medical case in the medical case database and the associated formula corresponding to the medical case in the formula basic database.
2. The method according to claim 1, wherein in S305, the medicinal material basic database of S304 is combined with medicinal material elements in the traditional Chinese medicinal material basic database of the existing traditional Chinese medicine formula combination, and a formula basic database is generated, wherein the method comprises the steps of sorting the medicinal material elements in the formula, combining the sorted Chinese medicinal material formula combinations according to the Chinese medicinal material codes set in S303, and combining the Chinese medicinal material codes to generate a basic formula code character string.
3. The method according to claim 1, wherein in S5, the external query interface of the database of chinese medical science is a two-class query option interface corresponding to the element composition thereof.
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN201911297599.9A CN111177117B (en) | 2019-12-17 | 2019-12-17 | Data processing method for traditional Chinese medicine medical records |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN201911297599.9A CN111177117B (en) | 2019-12-17 | 2019-12-17 | Data processing method for traditional Chinese medicine medical records |
Publications (2)
Publication Number | Publication Date |
---|---|
CN111177117A CN111177117A (en) | 2020-05-19 |
CN111177117B true CN111177117B (en) | 2023-06-16 |
Family
ID=70653956
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CN201911297599.9A Active CN111177117B (en) | 2019-12-17 | 2019-12-17 | Data processing method for traditional Chinese medicine medical records |
Country Status (1)
Country | Link |
---|---|
CN (1) | CN111177117B (en) |
Families Citing this family (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN113870971B (en) * | 2021-09-16 | 2022-08-09 | 黑龙江中医药大学 | Intelligent recommendation method for liver and gallbladder damp-heat medicine formula |
Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN107590146A (en) * | 2016-07-06 | 2018-01-16 | 北京搜狗科技发展有限公司 | A kind of prescription matching process and device, a kind of device for prescription matching |
WO2018120447A1 (en) * | 2016-12-28 | 2018-07-05 | 北京搜狗科技发展有限公司 | Method, device and equipment for processing medical record information |
CN110299206A (en) * | 2018-03-21 | 2019-10-01 | 华东师范大学 | A kind of more contents imply Di Li Cray distributed model and interpretation of the cause, onset and process of an illness method for digging is implied in Chinese medicine case |
CN110335684A (en) * | 2019-06-14 | 2019-10-15 | 电子科技大学 | The intelligent dialectical aid decision-making method of Chinese medicine based on topic model technology |
-
2019
- 2019-12-17 CN CN201911297599.9A patent/CN111177117B/en active Active
Patent Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN107590146A (en) * | 2016-07-06 | 2018-01-16 | 北京搜狗科技发展有限公司 | A kind of prescription matching process and device, a kind of device for prescription matching |
WO2018120447A1 (en) * | 2016-12-28 | 2018-07-05 | 北京搜狗科技发展有限公司 | Method, device and equipment for processing medical record information |
CN110299206A (en) * | 2018-03-21 | 2019-10-01 | 华东师范大学 | A kind of more contents imply Di Li Cray distributed model and interpretation of the cause, onset and process of an illness method for digging is implied in Chinese medicine case |
CN110335684A (en) * | 2019-06-14 | 2019-10-15 | 电子科技大学 | The intelligent dialectical aid decision-making method of Chinese medicine based on topic model technology |
Also Published As
Publication number | Publication date |
---|---|
CN111177117A (en) | 2020-05-19 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
CN109906449B (en) | Searching method and device | |
Meystre et al. | Automation of a problem list using natural language processing | |
US8239216B2 (en) | Searching an electronic medical record | |
US10423758B2 (en) | Computer system and information processing method | |
US20050015381A1 (en) | Database management system | |
US20090240523A1 (en) | Optimizing pharmaceutical treatment plans across multiple dimensions | |
US20190147988A1 (en) | Hospital matching of de-identified healthcare databases without obvious quasi-identifiers | |
CN110189831A (en) | A kind of case history knowledge mapping construction method and system based on dynamic diagram sequences | |
CN106415532A (en) | Medical care data search system | |
Lakshmi et al. | Association rule extraction from medical transcripts of diabetic patients | |
WO2014070278A2 (en) | Interoperable case series system | |
Ae Chun et al. | Social health data integration using semantic Web | |
CN107193996B (en) | Similar medical record matching and retrieving system | |
CN111177117B (en) | Data processing method for traditional Chinese medicine medical records | |
Liu et al. | Extracting patient demographics and personal medical information from online health forums | |
Ji et al. | Integrating unified medical language system and association mining techniques into relevance feedback for biomedical literature search | |
CN117290304A (en) | Retrieval system and method based on medical big data establishment | |
US20230377697A1 (en) | System and a way to automatically monitor clinical trials - virtual monitor (vm) and a way to record medical history | |
Carreiras et al. | Storagebit-a metadata-aware, extensible, semantic and hierarchical database for biosignals | |
Arwan et al. | Query Expansion Based On User Requirements Clustering for Finding Feature Location | |
Baghal et al. | Agile natural language processing model for pathology knowledge extraction and integration with clinical enterprise data warehouse | |
US11269937B2 (en) | System and method of presenting information related to search query | |
Ando et al. | Is In-hospital Meta-information Useful for Abstractive Discharge Summary Generation? | |
Shah-Mohammadi et al. | Entity extraction for clinical notes, a comparison between metamap and amazon comprehend medical | |
Orthuber | Collection of medical original data with search engine for decision support |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
PB01 | Publication | ||
PB01 | Publication | ||
SE01 | Entry into force of request for substantive examination | ||
SE01 | Entry into force of request for substantive examination | ||
GR01 | Patent grant | ||
GR01 | Patent grant |