CN111163763B - 用于抑制胆碱向三甲胺(tma)的转化的方法 - Google Patents
用于抑制胆碱向三甲胺(tma)的转化的方法 Download PDFInfo
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- CN111163763B CN111163763B CN201880064575.6A CN201880064575A CN111163763B CN 111163763 B CN111163763 B CN 111163763B CN 201880064575 A CN201880064575 A CN 201880064575A CN 111163763 B CN111163763 B CN 111163763B
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- tma
- choline
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- trimethylamine
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- 238000006243 chemical reaction Methods 0.000 title claims abstract description 71
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- 239000000203 mixture Substances 0.000 claims abstract description 61
- UYPYRKYUKCHHIB-UHFFFAOYSA-N trimethylamine N-oxide Chemical compound C[N+](C)(C)[O-] UYPYRKYUKCHHIB-UHFFFAOYSA-N 0.000 claims abstract description 46
- -1 allyl (dimethyl) sulfonium bromide Chemical compound 0.000 claims description 39
- 230000015572 biosynthetic process Effects 0.000 claims description 30
- 150000003839 salts Chemical class 0.000 claims description 25
- 239000003795 chemical substances by application Substances 0.000 claims description 21
- 125000003903 2-propenyl group Chemical group [H]C([*])([H])C([H])=C([H])[H] 0.000 claims description 19
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- 125000000217 alkyl group Chemical group 0.000 claims description 14
- 125000001494 2-propynyl group Chemical group [H]C#CC([H])([H])* 0.000 claims description 13
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- 239000002904 solvent Substances 0.000 description 1
- 238000001179 sorption measurement Methods 0.000 description 1
- 208000010110 spontaneous platelet aggregation Diseases 0.000 description 1
- 239000003381 stabilizer Substances 0.000 description 1
- 239000008117 stearic acid Substances 0.000 description 1
- 238000003860 storage Methods 0.000 description 1
- TYFQFVWCELRYAO-UHFFFAOYSA-L suberate(2-) Chemical compound [O-]C(=O)CCCCCCC([O-])=O TYFQFVWCELRYAO-UHFFFAOYSA-L 0.000 description 1
- 125000005346 substituted cycloalkyl group Chemical group 0.000 description 1
- SSTZGACKDAVIGZ-UHFFFAOYSA-N sulfanium;bromide Chemical compound [SH3+].[Br-] SSTZGACKDAVIGZ-UHFFFAOYSA-N 0.000 description 1
- PXQLVRUNWNTZOS-UHFFFAOYSA-N sulfanyl Chemical compound [SH] PXQLVRUNWNTZOS-UHFFFAOYSA-N 0.000 description 1
- BDHFUVZGWQCTTF-UHFFFAOYSA-M sulfonate Chemical compound [O-]S(=O)=O BDHFUVZGWQCTTF-UHFFFAOYSA-M 0.000 description 1
- 150000003463 sulfur Chemical class 0.000 description 1
- 150000003464 sulfur compounds Chemical class 0.000 description 1
- 229940032330 sulfuric acid Drugs 0.000 description 1
- 239000013595 supernatant sample Substances 0.000 description 1
- 238000010189 synthetic method Methods 0.000 description 1
- 235000002906 tartaric acid Nutrition 0.000 description 1
- 239000011975 tartaric acid Substances 0.000 description 1
- KKEYFWRCBNTPAC-UHFFFAOYSA-L terephthalate(2-) Chemical compound [O-]C(=O)C1=CC=C(C([O-])=O)C=C1 KKEYFWRCBNTPAC-UHFFFAOYSA-L 0.000 description 1
- NQRYJNQNLNOLGT-UHFFFAOYSA-N tetrahydropyridine hydrochloride Natural products C1CCNCC1 NQRYJNQNLNOLGT-UHFFFAOYSA-N 0.000 description 1
- 230000008719 thickening Effects 0.000 description 1
- 150000007970 thio esters Chemical class 0.000 description 1
- 150000003573 thiols Chemical class 0.000 description 1
- 229930192474 thiophene Natural products 0.000 description 1
- 150000003626 triacylglycerols Chemical class 0.000 description 1
- 150000003852 triazoles Chemical class 0.000 description 1
- 239000012588 trypsin Substances 0.000 description 1
- 238000002604 ultrasonography Methods 0.000 description 1
- 238000000870 ultraviolet spectroscopy Methods 0.000 description 1
- 230000002485 urinary effect Effects 0.000 description 1
- 210000001215 vagina Anatomy 0.000 description 1
- 230000002792 vascular Effects 0.000 description 1
- 210000003462 vein Anatomy 0.000 description 1
- 208000003663 ventricular fibrillation Diseases 0.000 description 1
- 230000035899 viability Effects 0.000 description 1
- 235000019154 vitamin C Nutrition 0.000 description 1
- 239000011718 vitamin C Substances 0.000 description 1
- 235000019165 vitamin E Nutrition 0.000 description 1
- 229940046009 vitamin E Drugs 0.000 description 1
- 239000011709 vitamin E Substances 0.000 description 1
- 235000021260 warm beverage Nutrition 0.000 description 1
- 229920003169 water-soluble polymer Polymers 0.000 description 1
- 229940111503 welchol Drugs 0.000 description 1
- 238000009736 wetting Methods 0.000 description 1
- 239000000080 wetting agent Substances 0.000 description 1
- 229940071104 xylenesulfonate Drugs 0.000 description 1
- 229940072168 zocor Drugs 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/095—Sulfur, selenium, or tellurium compounds, e.g. thiols
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/095—Sulfur, selenium, or tellurium compounds, e.g. thiols
- A61K31/10—Sulfides; Sulfoxides; Sulfones
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/275—Nitriles; Isonitriles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/38—Heterocyclic compounds having sulfur as a ring hetero atom
- A61K31/39—Heterocyclic compounds having sulfur as a ring hetero atom having oxygen in the same ring
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201762566975P | 2017-10-02 | 2017-10-02 | |
| US62/566975 | 2017-10-02 | ||
| PCT/US2018/053924 WO2019070676A1 (fr) | 2017-10-02 | 2018-10-02 | Procédés d'inhibition de la conversion de choline en triméthylamine (tma) |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN111163763A CN111163763A (zh) | 2020-05-15 |
| CN111163763B true CN111163763B (zh) | 2023-08-22 |
Family
ID=63963526
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201880064575.6A Active CN111163763B (zh) | 2017-10-02 | 2018-10-02 | 用于抑制胆碱向三甲胺(tma)的转化的方法 |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US10751301B2 (fr) |
| EP (1) | EP3522876B1 (fr) |
| CN (1) | CN111163763B (fr) |
| AU (1) | AU2018345747B2 (fr) |
| BR (1) | BR112020006108A2 (fr) |
| CA (1) | CA3076195C (fr) |
| MX (1) | MX2020003080A (fr) |
| PL (1) | PL3522876T3 (fr) |
| WO (1) | WO2019070676A1 (fr) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110959862B (zh) * | 2019-11-14 | 2021-08-13 | 南方医科大学 | 一种具有清除氧化三甲胺和抗炎功能的组合物及其制备方法和应用 |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2233935A1 (fr) * | 1973-06-19 | 1975-01-17 | Bayer Ag | |
| US9168233B2 (en) * | 2012-06-11 | 2015-10-27 | The Cleveland Clinic Foundation | Treatment and prevention of cardiovascular disease and thrombosis |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE1542826B1 (de) | 1966-06-01 | 1971-04-08 | Basf Ag | Sulfoniumverbindungen und deren Verwendung |
| FR1524922A (fr) * | 1966-06-01 | 1968-05-10 | Basf Ag | Agents entravant la croissance et modifiant l'habitus des plantes |
| FR1559102A (fr) | 1968-01-23 | 1969-03-07 | ||
| US3644531A (en) | 1968-08-13 | 1972-02-22 | Sankyo Co | 2-propynylsulfonium salts |
| US3651222A (en) | 1969-09-15 | 1972-03-21 | Monsanto Co | Nematocidal use of substituted dimethylsulfonium tetraphenylborates |
| EP0555058B1 (fr) | 1992-02-07 | 1997-05-07 | Toyo Ink Manufacturing Co., Ltd. | Complexe d'(oxo)sulfonium, composition polymérisable le contenant et méthode de polymérisation |
| JP4999043B2 (ja) * | 2006-02-13 | 2012-08-15 | 株式会社Ａｄｅｋａ | スルホニウム塩化合物、カチオン重合開始剤および熱硬化性組成物 |
| EP2222220B1 (fr) | 2007-12-05 | 2016-03-16 | The Cleveland Clinic Foundation | Composés de triméthylamine en tant que prédicteurs de risque de maladie cardiovasculaire |
| BR112018010873A2 (pt) | 2015-12-01 | 2019-04-30 | The Procter & Gamble Company | compostos e métodos para inibir a produção de trimetilamina |
| CN109640967B (zh) | 2016-06-29 | 2022-04-29 | 宝洁公司 | 抑制胆碱向三甲胺(tma)的转化的方法 |
-
2018
- 2018-10-02 WO PCT/US2018/053924 patent/WO2019070676A1/fr unknown
- 2018-10-02 MX MX2020003080A patent/MX2020003080A/es unknown
- 2018-10-02 US US16/149,882 patent/US10751301B2/en active Active
- 2018-10-02 BR BR112020006108-5A patent/BR112020006108A2/pt unknown
- 2018-10-02 EP EP18792732.2A patent/EP3522876B1/fr active Active
- 2018-10-02 CN CN201880064575.6A patent/CN111163763B/zh active Active
- 2018-10-02 PL PL18792732T patent/PL3522876T3/pl unknown
- 2018-10-02 CA CA3076195A patent/CA3076195C/fr active Active
- 2018-10-02 AU AU2018345747A patent/AU2018345747B2/en not_active Ceased
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2233935A1 (fr) * | 1973-06-19 | 1975-01-17 | Bayer Ag | |
| US9168233B2 (en) * | 2012-06-11 | 2015-10-27 | The Cleveland Clinic Foundation | Treatment and prevention of cardiovascular disease and thrombosis |
Non-Patent Citations (1)
| Title |
|---|
| A Comparative Study of Sulfonium Reversible Inhibitors of Cholinesterases of Various Animals;E. V. Rozengart 等;《Doklady Biochemistry and Biophysics》;20041231;第395卷;第61-64页 * |
Also Published As
| Publication number | Publication date |
|---|---|
| WO2019070676A1 (fr) | 2019-04-11 |
| AU2018345747B2 (en) | 2021-03-18 |
| EP3522876A1 (fr) | 2019-08-14 |
| EP3522876B1 (fr) | 2021-02-24 |
| US10751301B2 (en) | 2020-08-25 |
| CN111163763A (zh) | 2020-05-15 |
| US20190099384A1 (en) | 2019-04-04 |
| CA3076195C (fr) | 2022-06-21 |
| AU2018345747A1 (en) | 2020-04-09 |
| BR112020006108A2 (pt) | 2020-09-24 |
| MX2020003080A (es) | 2022-02-18 |
| CA3076195A1 (fr) | 2019-04-11 |
| PL3522876T3 (pl) | 2021-06-28 |
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| US10849866B2 (en) | Methods for inhibiting conversion of choline to trimethylamine (TMA) | |
| CN111163765B (zh) | 用于抑制胆碱向三甲胺(tma)的转化的方法 | |
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