CN111157662A - Multi-column rotary valve and chromatograph - Google Patents
Multi-column rotary valve and chromatograph Download PDFInfo
- Publication number
- CN111157662A CN111157662A CN202010113019.2A CN202010113019A CN111157662A CN 111157662 A CN111157662 A CN 111157662A CN 202010113019 A CN202010113019 A CN 202010113019A CN 111157662 A CN111157662 A CN 111157662A
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- stator
- rotor
- rotary valve
- cell body
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
- G01N30/02—Column chromatography
- G01N30/04—Preparation or injection of sample to be analysed
- G01N30/16—Injection
- G01N30/20—Injection using a sampling valve
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
- G01N30/02—Column chromatography
- G01N30/04—Preparation or injection of sample to be analysed
- G01N30/16—Injection
- G01N30/20—Injection using a sampling valve
- G01N2030/202—Injection using a sampling valve rotary valves
Abstract
The invention discloses a rotary valve. The rotary valve of the present invention comprises: a stator and a rotor; the stator is provided with a fluid inlet hole, a fluid outlet hole and 2N chromatographic column connecting holes which are uniformly distributed in the circumference; wherein N is a positive integer greater than 1. The invention has the beneficial effects that: the selection of a plurality of components is realized on the same valve, and the fluid can bypass, flow forwards and flow backwards through the components, so that more automatic operation can be realized in chromatographic analysis work.
Description
Technical Field
The invention relates to the field of chromatographs, in particular to a rotary valve.
Background
Multiple chromatographic columns are often used on the chromatograph and need to be switched frequently, and liquid passing through the chromatographic columns often needs to be changed in direction to back flush the chromatographic columns and does not pass through the chromatographic columns, so that the quick change of system fluid is facilitated. The conventional approach is to require 2 (1 reversing valve and 1 multi-column valve) or 3 valves (1 reversing valve and 2 selector valves) to achieve these functions.
Disclosure of Invention
The invention aims to provide a rotary valve, which realizes the switching of a plurality of columns (2 or more) on one valve and can realize the functions of bypass, forward flow and reverse flow of parts. The operation is convenient, the dead volume is avoided, the number of valves is reduced, and the failure rate and the use cost of the system are reduced.
In order to solve the above technical problem, the present invention provides a rotary valve, comprising: a stator and a rotor;
the stator is provided with a fluid inlet hole, a fluid outlet hole and 2N chromatographic column connecting holes which are uniformly distributed in the circumference; wherein N is a positive integer greater than 1;
the fluid inlet holes and the fluid outlet holes are symmetrically distributed around the center of the stator, and the distance from the fluid inlet holes and the fluid outlet holes to the center of the stator is R2; the distance from the 2N chromatographic column connecting holes to the center of the stator is R1, wherein R1 is greater than R2;
a first stator groove body and a second stator groove body are arranged on one surface of the stator facing the rotor;
the first stator groove body and the second stator groove body are symmetrically distributed around the center of the stator, the distances from the first stator groove body and the second stator groove body to the center of the stator are R1, the included angles formed by the starting point and the stopping point of the first stator groove body and the second stator groove body and the center of the stator are D1, and D1 is smaller than 360/(2N +2) degrees;
the rotor is in fluid seal with the stator, the rotor is coaxial with the stator, the rotor can rotate relative to the stator, and a first rotor groove body and a second rotor groove body are arranged on one surface of the rotor facing the stator;
the first cell body of rotor with the second cell body of turning centers on the central symmetric distribution of rotor, the first cell body of rotor with the second cell body of rotor is the arc cell body that central angle is 180 degrees, the first cell body of rotor with the second cell body of rotor arrives the distance at the center of rotor is R2, the first cell body of rotor with the both ends of rotor second cell body all extend to with the center of rotor is centre of a circle and on the radius is the circumference of R1, the extension of the first cell body of rotor with the contained angle of the extension of rotor second cell body is D1.
In one embodiment, N is 3.
In one embodiment, N is 2.
In one embodiment, R2 is half of R1.
In one embodiment, D1 is equal to 180/(2N + 2).
In one embodiment, the first stator slot is a circular arc slot.
In one embodiment, the stator second slot is a circular arc slot.
In one embodiment, the first stator slot is a straight slot.
In one embodiment, the stator second slot is a straight slot.
A chromatograph comprising the rotary valve.
The invention has the beneficial effects that:
the selection of a plurality of components is realized on the same valve, and the fluid can bypass, flow forwards and flow backwards through the components, so that more automatic operation can be realized in chromatographic analysis work.
Drawings
FIG. 1 is a schematic view of a stator in a rotary valve of the present invention.
Fig. 2 is a schematic view of the rotor in the rotary valve of the present invention.
Figure 3 is a schematic representation of a rotary valve embodying the bypass of the present invention.
Fig. 4, 5 and 6 are schematic views of different chromatography column components of a rotary valve of the invention for achieving positive and reverse flow, respectively.
Detailed Description
The present invention is further described below in conjunction with the following figures and specific examples so that those skilled in the art may better understand the present invention and practice it, but the examples are not intended to limit the present invention.
A rotary valve, comprising: a stator and a rotor;
the stator is provided with a fluid inlet hole, a fluid outlet hole and 2N chromatographic column connecting holes which are uniformly distributed in the circumference; wherein N is a positive integer greater than 1; (it will be understood that the uniform circumferential distribution herein means uniform distribution of the angles formed by the fluid inlet holes, the fluid outlet holes and the 2N connecting holes of the chromatographic column with the center of the stator)
The fluid inlet holes and the fluid outlet holes are symmetrically distributed around the center of the stator, and the distance from the fluid inlet holes and the fluid outlet holes to the center of the stator is R2; the distance from the 2N chromatographic column connecting holes to the center of the stator is R1, wherein R1 is greater than R2;
a first stator groove body and a second stator groove body are arranged on one surface of the stator facing the rotor;
the first stator groove body and the second stator groove body are symmetrically distributed around the center of the stator, the distances from the first stator groove body and the second stator groove body to the center of the stator are R1, the included angles formed by the starting point and the stopping point of the first stator groove body and the second stator groove body and the center of the stator are D1, and D1 is smaller than 360/(2N +2) degrees;
the rotor and the stator are in fluid seal (namely, fluid between the rotor and the stator cannot flow out from a gap between the rotor and the stator), the rotor and the stator are coaxial, the rotor can rotate relative to the stator, and one surface of the rotor, facing the stator, is provided with a first rotor groove body and a second rotor groove body;
the first cell body of rotor with the second cell body of turning centers on the central symmetric distribution of rotor, the first cell body of rotor with the second cell body of rotor is the arc cell body that central angle is 180 degrees, the first cell body of rotor with the second cell body of rotor arrives the distance at the center of rotor is R2, the first cell body of rotor with the both ends of rotor second cell body all extend to with the center of rotor is centre of a circle and on the radius is the circumference of R1, the extension of the first cell body of rotor with the contained angle of the extension of rotor second cell body is D1.
In one embodiment, N is 3.
In one embodiment, N is 2.
In one embodiment, R2 is half of R1.
In one embodiment, D1 is equal to 180/(2N + 2).
In one embodiment, the first stator slot is a circular arc slot.
In one embodiment, the stator second slot is a circular arc slot.
In one embodiment, the first stator slot is a straight slot.
In one embodiment, the stator second slot is a straight slot.
A chromatograph comprising the rotary valve.
A specific application scenario of the present invention is described below:
a method for changing the direction of flow path and a rotary valve, particularly a three-position valve, is provided with three chromatographic column components C1, C2 and C3, including a stator and a rotor. The driving rotor can adopt various driving devices, and can be a stepping motor in common.
The stator is shown in fig. 1, with 8 holes in the stator, evenly distributed at an angle of 45 degrees, with ports (1a,2a,3a,1b,2b,3b) for the connection of the components (i.e. the column connection ports described above) on the circumference of diameter R1, inlets (a) and outlets (b) for the fluid (i.e. fluid inlet ports, fluid outlet ports described above) on the circumference of R2, and 2 slots (C4 and C5) on the circumference of R1 of the stator, the start and stop of which forms an angle of D1 degrees (0 degrees from the centre of the circle)0<D1<450In this case 22.50For example).
The rotor is shown in fig. 2, and has 2 slots (C6 and C7 in fig. 2), wherein the semicircular slots are located on the circumference of R2 and coincide with R2 of the stator. The two ends of the groove respectively extend to the circumference of R1(R1 is consistent with R1 of the stator). The included angle of the extension part is D1 degrees (0)0<D1<450In this case 22.50For example), the rotor is rotated by the driving device and can rotate to different positions.
The inlet of the fluid is connected with the port a of the stator, the outlet of the fluid is connected with the port b of the stator, the component C1 is respectively connected with the port 1a and the port 1b of the stator, the component C2 is respectively connected with the port 2a and the port 2b of the stator, the component C3 is respectively connected with the port 3a and the port 3b of the stator, the motor drives the rotor to rotate to the position 1 (as shown in figure 3, the position is temporarily considered that the rotor is at 0 degree), at the moment, the fluid enters from the port a, passes through the grooves C6 and C7 of the rotor and the grooves C4 and C5 of the stator respectively, and flows out from the port b. This state is a bypass state, and fluid does not pass through components C1, C2, and C3.
When the rotor rotates 45 degrees clockwise (with the initial position 1 as a reference point), and reaches the position 2 (as shown in the left side of fig. 4), the fluid enters from the port a of the stator, flows out from the port 1a after passing through the groove of the rotor, passes through the component C1 from top to bottom, flows into the valve from the port 1b of the stator, and flows out of the valve from the port b of the stator after passing through the groove of the rotor. This state is positive flow through component C1. When the rotor rotates 22.5 degrees clockwise (with the initial position 1 as a reference point) to the position 3 (as shown on the right side of fig. 4), the fluid enters from the port a of the stator, flows out from the port 1b after passing through the groove of the rotor, passes through the component C1 from bottom to top, flows into the valve from the port 1a of the stator, and flows out of the valve from the port b of the stator after passing through the groove of the rotor. This condition is reversed flow through block C1.
When the rotor rotates 90 degrees clockwise (using the initial position 1 as a reference point) to the position 4 (as shown in the left side of fig. 5), the fluid enters from the port a of the stator, flows out from the port 2a after passing through the groove of the rotor, passes through the component C2 from top to bottom, flows into the valve from the port 2b of the stator, and flows out of the valve from the port b of the stator after passing through the groove of the rotor. This state is positive flow through component C2. When the rotor rotates clockwise 67.5 degrees (taking the initial position 1 as a reference point) to the position 5 (as shown on the right side of fig. 5), the fluid enters from the port a of the stator, flows out from the port 2b after passing through the groove of the rotor, passes through the component C2 from bottom to top, flows into the valve from the port 2a of the stator, and flows out of the valve from the port b of the stator after passing through the groove of the rotor. This condition is reversed flow through block C2.
When the rotor rotates 135 degrees clockwise (with the initial position 1 as a reference point), and reaches the position 6 (as shown in the left side of fig. 6), the fluid enters from the port a of the stator, flows out from the port 3a after passing through the groove of the rotor, passes through the component C3 from top to bottom, flows into the valve from the port 3b of the stator, and flows out of the valve from the port b of the stator after passing through the groove of the rotor. This state is positive flow through component C3. When the rotor rotates clockwise 112.5 degrees (with the initial position 1 as a reference point) to position 7 (as shown on the right side of fig. 6), the fluid enters from the port a of the stator, flows out from the port 3b after passing through the groove of the rotor, passes through the component C3 from bottom to top, flows into the valve from the port 3a of the stator, and flows out of the valve from the port b of the stator after passing through the groove of the rotor. This condition is reversed flow through block C3.
By performing the above steps, 3 parts of positive flow, reverse flow or bypass of the fluid respectively can be realized. When bypassing, the fluid will pass through all the grooves, thereby avoiding dead volume and avoiding fluid residue.
The above-mentioned embodiments are merely preferred embodiments for fully illustrating the present invention, and the scope of the present invention is not limited thereto. The equivalent substitution or change made by the technical personnel in the technical field on the basis of the invention is all within the protection scope of the invention. The protection scope of the invention is subject to the claims.
Claims (10)
1. A rotary valve, comprising: a stator and a rotor;
the stator is provided with a fluid inlet hole, a fluid outlet hole and 2N chromatographic column connecting holes which are uniformly distributed in the circumference; wherein N is a positive integer greater than 1;
the fluid inlet holes and the fluid outlet holes are symmetrically distributed around the center of the stator, and the distance from the fluid inlet holes and the fluid outlet holes to the center of the stator is R2; the distance from the 2N chromatographic column connecting holes to the center of the stator is R1, wherein R1 is greater than R2;
a first stator groove body and a second stator groove body are arranged on one surface of the stator facing the rotor;
the first stator groove body and the second stator groove body are symmetrically distributed around the center of the stator, the distances from the first stator groove body and the second stator groove body to the center of the stator are R1, the included angles formed by the starting point and the stopping point of the first stator groove body and the second stator groove body and the center of the stator are D1, and D1 is smaller than 360/(2N +2) degrees;
the rotor is in fluid seal with the stator, the rotor is coaxial with the stator, the rotor can rotate relative to the stator, and a first rotor groove body and a second rotor groove body are arranged on one surface of the rotor facing the stator;
the first cell body of rotor with the second cell body of turning centers on the central symmetric distribution of rotor, the first cell body of rotor with the second cell body of rotor is the arc cell body that central angle is 180 degrees, the first cell body of rotor with the second cell body of rotor arrives the distance at the center of rotor is R2, the first cell body of rotor with the both ends of rotor second cell body all extend to with the center of rotor is centre of a circle and on the radius is the circumference of R1, the extension of the first cell body of rotor with the contained angle of the extension of rotor second cell body is D1.
2. The rotary valve as set forth in claim 1 wherein N is 3.
3. The rotary valve as set forth in claim 1 wherein N is 2.
4. The rotary valve of claim 1 wherein R2 is one-half of R1.
5. The rotary valve as set forth in claim 1 wherein D1 is equal to 180/(2N + 2).
6. The rotary valve as set forth in claim 1 wherein the stator first slot is a circular arc slot.
7. The rotary valve as set forth in claim 1 wherein the stator second slot is a circular arc slot.
8. The rotary valve of claim 1, wherein the stator first slot is a linear slot.
9. The rotary valve of claim 1, wherein the stator second slot is a linear slot.
10. Chromatograph comprising a rotary valve according to claims 1 to 9.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202010113019.2A CN111157662A (en) | 2020-02-24 | 2020-02-24 | Multi-column rotary valve and chromatograph |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202010113019.2A CN111157662A (en) | 2020-02-24 | 2020-02-24 | Multi-column rotary valve and chromatograph |
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| Publication Number | Publication Date |
|---|---|
| CN111157662A true CN111157662A (en) | 2020-05-15 |
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202010113019.2A Pending CN111157662A (en) | 2020-02-24 | 2020-02-24 | Multi-column rotary valve and chromatograph |
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| Country | Link |
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| CN (1) | CN111157662A (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN114235898A (en) * | 2021-12-14 | 2022-03-25 | 苏州英赛斯智能科技有限公司 | Multi-position rotary valve |
-
2020
- 2020-02-24 CN CN202010113019.2A patent/CN111157662A/en active Pending
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN114235898A (en) * | 2021-12-14 | 2022-03-25 | 苏州英赛斯智能科技有限公司 | Multi-position rotary valve |
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Address after: Building 101, Building 13, No. 998 Pangnan Road, Jiangling Street, Wujiang District, Suzhou City, Jiangsu Province, 215000 Applicant after: SUZHOU YINGSAISI INTELLIGENT TECHNOLOGY Co.,Ltd. Address before: 215000 No. 99, yunchuang Road, Wujiang Economic and Technological Development Zone, Suzhou, Jiangsu Applicant before: SUZHOU YINGSAISI INTELLIGENT TECHNOLOGY Co.,Ltd. |