CN107407664B - Rotary valve and chromatography system - Google Patents
Rotary valve and chromatography system Download PDFInfo
- Publication number
- CN107407664B CN107407664B CN201680019723.3A CN201680019723A CN107407664B CN 107407664 B CN107407664 B CN 107407664B CN 201680019723 A CN201680019723 A CN 201680019723A CN 107407664 B CN107407664 B CN 107407664B
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- hole
- port
- rotor
- inner stator
- stator face
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
- G01N30/02—Column chromatography
- G01N30/04—Preparation or injection of sample to be analysed
- G01N30/16—Injection
- G01N30/20—Injection using a sampling valve
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- F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
- F16—ENGINEERING ELEMENTS AND UNITS; GENERAL MEASURES FOR PRODUCING AND MAINTAINING EFFECTIVE FUNCTIONING OF MACHINES OR INSTALLATIONS; THERMAL INSULATION IN GENERAL
- F16K—VALVES; TAPS; COCKS; ACTUATING-FLOATS; DEVICES FOR VENTING OR AERATING
- F16K11/00—Multiple-way valves, e.g. mixing valves; Pipe fittings incorporating such valves
- F16K11/02—Multiple-way valves, e.g. mixing valves; Pipe fittings incorporating such valves with all movable sealing faces moving as one unit
- F16K11/06—Multiple-way valves, e.g. mixing valves; Pipe fittings incorporating such valves with all movable sealing faces moving as one unit comprising only sliding valves, i.e. sliding closure elements
- F16K11/072—Multiple-way valves, e.g. mixing valves; Pipe fittings incorporating such valves with all movable sealing faces moving as one unit comprising only sliding valves, i.e. sliding closure elements with pivoted closure members
- F16K11/074—Multiple-way valves, e.g. mixing valves; Pipe fittings incorporating such valves with all movable sealing faces moving as one unit comprising only sliding valves, i.e. sliding closure elements with pivoted closure members with flat sealing faces
- F16K11/0743—Multiple-way valves, e.g. mixing valves; Pipe fittings incorporating such valves with all movable sealing faces moving as one unit comprising only sliding valves, i.e. sliding closure elements with pivoted closure members with flat sealing faces with both the supply and the discharge passages being on one side of the closure plates
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
- G01N30/02—Column chromatography
- G01N30/04—Preparation or injection of sample to be analysed
- G01N30/16—Injection
- G01N30/20—Injection using a sampling valve
- G01N2030/202—Injection using a sampling valve rotary valves
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- Engineering & Computer Science (AREA)
- General Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Analytical Chemistry (AREA)
- Biochemistry (AREA)
- Physics & Mathematics (AREA)
- General Physics & Mathematics (AREA)
- Immunology (AREA)
- Pathology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Mechanical Engineering (AREA)
- Multiple-Way Valves (AREA)
- Sliding Valves (AREA)
Abstract
The present invention relates to a rotary valve and a chromatography system comprising such a rotary valve. The rotary valve comprises a stator with an inner stator face, and a rotor with an inner rotor face arranged in sealing contact with the inner stator face, the rotor (1) being rotatably movable relative to the inner stator face (202) about a Rotational Axis (RA) to a plurality of rotor positions, wherein the stator comprises ports and apertures and the rotor comprises two or more rotor interconnecting passages for selective fluid interconnection of said apertures relative to the rotor positions, and wherein the rotor interconnecting passages are arranged: in the rotated position, the first hole (S) is connected to the fourth hole (LF) and the second hole (W) is connected to the third hole (LE). And in the rotated position, the eighth hole (SP) is connected to the seventh hole (PCFP). And in the rotated position, the eighth hole (SP) is connected to the fifth hole (TC) and the sixth hole (FC) is connected to the seventh hole (PCFP). And in the rotated position, the eighth hole (SP) is connected to the third hole (LE), the fourth hole (LF) is connected to the fifth hole (TC), and the sixth hole (FC) is connected to the seventh hole (PCFP).
Description
Technical Field
The present invention relates to valves in chromatography systems. In particular, the present invention relates to rotary valves and chromatography systems using such valves.
Background
Valves are commonly used in devices involving the transport of fluids. A typical type of valve (e.g., used in a moderate-sized laboratory system) is a rotary valve.
In general, rotary valves have a stationary body (referred to herein as a stator) that cooperates with a rotating body (referred to herein as a rotor).
The stator is provided with a number of inlet and outlet ports. The ports are in fluid communication with a corresponding set of apertures on the inner stator face via the apertures. The inner stator face is the inner surface of the stator which is in fluid tight contact with the inner rotor face of the rotor. The rotor is typically formed as a disc and in rotational cooperation the inner rotor face is pressed against the inner stator face. The inner rotor face is provided with one or more grooves which interconnect different apertures depending on the rotational position of the rotor relative to the stator.
The rotary valve may be designed to withstand high pressures (e.g., pressures greater than 25 MPa). It can be made from a range of materials such as stainless steel, high performance polymeric materials and ceramics.
The number of inlets/outlets and the design of the grooves in the rotor or stator reflect the intended use of a particular valve. A common type of multi-purpose valve has one inlet port (typically placed on the rotational axis of the valve) and a certain number of outlet ports placed equidistantly around the inlet port. The rotor has a single radially extending groove with one end at the centre of rotation, thereby always connecting to the inlet, and the other end connecting to either outlet depending on the angular position of the rotor relative to the stator. Such a valve is useful for directing flow from an inlet to any outlet (one at a time).
Chromatography systems known in the art often include a separate injection rotary valve and a separate column rotary valve. Some chromatography systems include a single rotary valve that requires manual connection and disconnection of the necessary connecting tubing for the syringe and the column. Such manual connection and disconnection is associated with several potential problems (e.g. risk of errors in the connection of tubing/capillary, wear of the connections, limited possibilities to automate the operation of the chromatography system).
It is therefore an object of the present invention to avoid some of the disadvantages and disadvantages mentioned in the foregoing.
Disclosure of Invention
One or more of the above objects, as well as further possible objects that may be conceived from the following disclosure, are achieved by a first aspect of the invention, which consists of a rotary valve comprising a stator with an inner stator face and a rotor with an inner rotor face arranged in sealing contact with the inner stator face. The rotor is rotatably movable relative to the inner stator face about an axis of rotation to a plurality of rotor positions. The stator includes: the first port in fluid contact with the first bore at the inner stator face, the second port in fluid contact with the second bore at the inner stator face, the third port in fluid contact with the third bore at the inner stator face, the fourth port in fluid contact with the fourth bore at the inner stator face, the fifth port in fluid contact with the fifth bore at the inner stator face, the sixth port in fluid contact with the sixth bore at the inner stator face, the seventh port in fluid contact with the seventh bore at the inner stator face, and the eighth port in fluid contact with the eighth bore at the inner stator face. The rotor comprises two or more rotor interconnection passages for selective fluid interconnection of the bores relative to the rotor position, and wherein the rotor interconnection passages are arranged to: in the first rotational position, the first bore is connected to the fourth bore, the second bore is connected to the third bore, and the eighth bore is connected to the seventh bore. The rotor interconnection path is further arranged to: in the second rotational position, the first hole is connected to the fourth hole, the second hole is connected to the third hole, the eighth hole is connected to the fifth hole, and the sixth hole is connected to the seventh hole. The rotor interconnection path is further arranged to: in the third rotational position, the eighth hole is connected to the third hole, the fourth hole is connected to the fifth hole, and the sixth hole is connected to the seventh hole. According to other aspects of the invention, at least one of the rotor interconnect passages includes a curved groove.
The above object, and further possible objects, are achieved by a second aspect of the invention, consisting of a chromatography system comprising: a rotary valve according to the first aspect of the invention, a syringe connected to a first port, waste connected to a second port, a loop connected at a first end to a third port and at a second end to a fourth port. The chromatography system further comprises: a column connected at a first end to a fifth port and at a second end to a sixth port, a post-column flowpath connected to a seventh port, and a system pump connected to an eighth port. The rotary valve is configured to: in a first rotational position, the syringe is connected to the second end of the loop, the waste is connected to the first end of the loop, and the system pump is connected to the post column flowpath. The rotary valve is configured to: in the second rotational position, the syringe is connected to the second end of the loop, the waste is connected to the first end of the loop, the system pump is connected to the first end of the column, and the second end of the column is connected to the post-column flowpath. The rotary valve is configured to: in a third rotational position, the system pump is connected to the first end of the column, the second end of the loop is connected to the first end of the column, and the second end of the column is connected to the post-column flowpath.
An advantage of the present invention is that the rotary valve avoids the need for a separate injection valve as well as a column valve.
Another advantage of the present invention is that an automated chromatography system can be provided.
Additional objects and advantages will be apparent to those skilled in the art from the detailed description and the accompanying drawings.
Drawings
FIG. 1 is a schematic perspective view of a rotary valve;
FIG. 2 is a schematic perspective view of a stator;
FIG. 3 is a view of the inner rotor face of the rotor;
FIG. 4 is a schematic view of a butt plane between a stator and a rotor;
FIG. 5 is a schematic view of a butt plane between a stator and a rotor;
FIG. 6 is a schematic view of a butt plane between a stator and a rotor;
FIG. 7 is a schematic diagram of a chromatography system;
FIG. 8 is a schematic diagram of a chromatography system; and
FIG. 9 is a schematic diagram of a chromatography system.
Detailed Description
The main parts of a typical rotary valve 100 are schematically shown in fig. 1 (where no brackets or similar carrying or fastening elements are shown). The rotary valve 100 has a stator 101, a rotor 103, a rotary shaft 105, which may optionally be provided with means for identifying its angular position (not shown), and a drive unit 106, typically comprising a gearbox and a motor (although the valve may also be operated manually). The rotor is rotatable relative to the stator about a rotational axis RA of the valve.
The stator 101 is fixed relative to the appliance (into which it is built) and is provided with ports for fluid communication with the fluid source/outlet and any components with which the valve cooperates. The ports may be positioned on any suitable portion of the stator and in any suitable direction. The port is provided with means for connecting a capillary or tubing. Such devices may be of any suitable type, such as conventional Valco linkers known to those skilled in the art. The ports are in fluid communication via channels with a corresponding set of holes on the inner stator face 202 (i.e., the surface of the stator that contacts the rotor 103 during operation).
The rotor 103 is typically formed as a disk and has an inner rotor face 401 which during operation is pressed against the flat inner stator face 202 to achieve a sealing contact therebetween. The inner rotor face 401 is provided with one or more interconnecting passages which interconnect different apertures of the inner stator face 202 depending on the rotational position of the rotor relative to the stator. The interconnecting passage may be any type of passage capable of providing fluid contact between two apertures, and may include an internal channel with discrete apertures, grooves in the inner rotor face, or the like.
Fig. 2 illustrates an embodiment of the stator 103. The stator 103 comprises an inner stator face 202. Eight holes are provided in the inner stator face 202. The stator 103 further includes: a first port 104a in fluid contact with the first bore S at the inner stator face 202, a second port 104b in fluid contact with the second bore W at the inner stator face 202, a third port 104c in fluid contact with the third bore LE at the inner stator face 202. The stator further includes: a fourth port 104d in fluid contact with the fourth hole LF at the inner stator face 202, a fifth port 104e in fluid contact with the fifth hole TC at the inner stator face 202, a sixth port 104f in fluid contact with the sixth hole FC at the inner stator face 202, a seventh port 104g in fluid contact with the seventh hole PCFP at the inner stator face 202, an eighth port 104g in fluid contact with the eighth hole SP at the inner stator face 202;
the eighth port 104h is in fluid contact with an eighth hole SP at the center of the inner stator face 202.
The first to seventh holes S to PCFP may be circularly distributed around the eighth hole SP in numerical order from the first to seventh holes. Adjacent holes may be equally spaced and circularly distributed.
Fig. 3 illustrates the inner rotor face 401 in an end view. The inner rotor face includes at least one interconnecting passage (402a-402g) of the type mentioned above that is configured to connect at least two apertures on the inner stator face 202.
Fig. 4 is a plan view of the interface plane between the inner stator face 202 and the inner rotor face 401. This view illustrates a first rotational position in which the rotor interconnection path is arranged to connect the first hole S to the fourth hole LF, the second hole W to the third hole LE, and the eighth hole SP to the seventh hole PCFP;
fig. 5 is a plan view of the interface plane between the inner stator face 202 and the inner rotor face 401. This view illustrates a second rotational position in which the rotor interconnection path is arranged to connect the first hole S to the fourth hole LF, the second hole W to the third hole LE, the eighth hole SP to the fifth hole TC, and the sixth hole FC to the seventh hole PCFP.
Fig. 6 is a plan view of the interface plane between the inner stator face 202 and the inner rotor face 401. This view illustrates a third rotational position in which the rotor interconnection path is arranged to connect the eighth hole SP to the third hole LE, the fourth hole LF to the fifth hole TC, and the sixth hole FC to the seventh hole PCFP.
FIG. 7 is a schematic diagram of an embodiment of a chromatography system, generally designated 701. The system comprises a rotary valve 101 of the type described above. The injector 702 is connected to the first port 104a of the stator 103, resulting in a fluid interconnection passage being formed between the injector 702 and the first bore S. Waste (waste)703 is connected to the second port 104b of the stator 103, resulting in a fluid interconnection path being formed between the waste and the second bore W. A first end of the loop 704 is connected to the third port 104c of the stator 103 resulting in a fluid interconnection path being formed between the loop 704 and the third bore LE. The second end of the loop 704 is connected to the fourth port 104d of the stator 103, resulting in a fluid interconnection passage being formed between the loop 703 and the fourth bore LF. The first end of the post 705 is connected to the fifth port 104e of the stator 103, resulting in a fluid interconnection passage being formed between the post 705 and the fifth bore TC. The second end of the post 705 is connected to the sixth port 104f of the stator 103, resulting in a fluid interconnection passage being formed between the post and the sixth bore FC. The post fluid passage 706 is connected to the seventh port 104g, resulting in a fluid interconnection passage being formed between the seventh hole PCFP and the post fluid passage 706. Finally, the system pump 707 is connected to the eighth port 104h, resulting in a fluid interconnection path being formed between the eighth bore SP and the system pump 707.
Further, in fig. 7, the rotor is in a first rotational position, resulting in the syringe 702 being connected to the second end of the loop 704, the waste 703 being connected to the first end of the loop 704, and the system pump being connected to the post-column flow path 706.
In fig. 8, the same system 701 as in fig. 7 is illustrated, the difference between the configuration in the system according to fig. 7 and the system according to fig. 8 being: in fig. 8, the rotor is in a second rotational position, resulting in the syringe 702 being connected to the second end of the loop 704 and the waste 703 being connected to the first end of the loop 704. Further, the rotor is in a second rotational position, resulting in the system pump 707 being connected to a first end of the column 705 and a second end of the column being connected to the post column flow path 706.
Fig. 9 discloses a system wherein the rotor is in a third rotational position, resulting in the system pump being connected to a first end of a loop 704, a second end of the loop 704 being connected to a first end of a column 705, and a second end of the column being connected to a post column flow path 706.
The chromatographic system discussed above solves some of the problems associated with known chromatographic systems using one conventional rotary valve and associated manual connections.
Claims (5)
1. A rotary valve (100) comprising a stator (101) with an inner stator face (202), and a rotor (103) with an inner rotor face (401) arranged in sealing contact with the inner stator face (202), the rotor (103) being rotatably movable to a plurality of rotor positions around a Rotational Axis (RA) with respect to the inner stator face (202), wherein the stator comprises:
a first port (104a) in fluid contact with a first bore (S) at the inner stator face (202);
a second port (104b) in fluid contact with a second bore (W) at the inner stator face (202);
a third port (104c) in fluid contact with a third aperture (LE) at the inner stator face (202);
a fourth port (104d) in fluid contact with a fourth bore (LF) at the inner stator face (202);
a fifth port (104e) in fluid contact with a fifth bore (TC) at the inner stator face (202);
a sixth port (104f) in fluid contact with a sixth bore (FC) at the inner stator face (202);
a seventh port (104g) in fluid contact with a seventh hole (PCFP) at the inner stator face (202);
an eighth port (104g) in fluid contact with an eighth bore (SP) at the inner stator face (202);
and the rotor (103) comprises seven rotor interconnection passages (402a-402g) for selective fluid interconnection of the bore relative to rotor position, and wherein the rotor interconnection passages are arranged to:
in the first rotational position:
connecting the first hole (S) to the fourth hole (LF);
connecting the second hole (W) to the third hole (LE);
connecting the eighth hole (SP) to the seventh hole (PCFP);
in the second rotational position:
connecting the first hole (S) to the fourth hole (LF);
connecting the second hole (W) to the third hole (LE);
connecting the eighth hole (SP) to the fifth hole (TC);
connecting the sixth hole (FC) to the seventh hole (PCFP);
in the third rotational position:
connecting the eighth hole (SP) to the third hole (LE);
connecting the fourth hole (LF) to the fifth hole (TC);
connecting the sixth hole (FC) to the seventh hole (PCFP).
2. The rotary valve of claim 1, wherein at least one of the rotor interconnection passages includes a curved groove.
3. A rotary valve according to claim 1 or claim 2, wherein one hole from the group of holes comprising the first hole (S) to the eighth hole (SP) is arranged in the centre of the inner stator face and the other holes of the group are arranged circularly around the hole in the centre of the inner stator face.
4. A rotary valve according to claim 3, characterized in that the eighth hole (SP) is arranged in the center of the inner stator face and the first to seventh holes (PCFP) are distributed circularly around the eighth hole (SP) in numerical order from the first to seventh holes.
5. A chromatography system comprising a rotary valve according to any of claims 1 to 4, wherein the system further comprises:
a syringe (702) connected to the first port (104 a);
a waste material (703) connected to the second port (104 b);
a loop (704) connected at a first end to the third port (104c) and at a second end to the fourth port (104 d);
a post (705) connected at a first end to the fifth port (104e) and at a second end to the sixth port (104 f);
a post-column flow path (706) connected to the seventh port (104 g); and a system pump (707) connected to the eighth port (104 h); and is
Wherein the rotary valve (101) is configured to:
in the first rotational position:
connecting the syringe to a second end of the loop;
connecting the waste material to a first end of the loop;
connecting the system pump to the post column flowpath;
in the second rotational position:
connecting the syringe to a second end of the loop;
connecting the waste material to a first end of the loop;
connecting the system pump to a first end of the column;
connecting a second end of the column to the post-column flow path; and
in the third rotational position:
connecting the system pump to a first end of the column;
connecting a second end of the loop to a first end of the column;
connecting a second end of the column to the post-column flow path.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GBGB1505421.6A GB201505421D0 (en) | 2015-03-30 | 2015-03-30 | A rotary valve and a chromatography system |
GB1505421.6 | 2015-03-30 | ||
PCT/EP2016/056404 WO2016156152A1 (en) | 2015-03-30 | 2016-03-23 | A rotary valve and a chromatography system |
Publications (2)
Publication Number | Publication Date |
---|---|
CN107407664A CN107407664A (en) | 2017-11-28 |
CN107407664B true CN107407664B (en) | 2020-04-14 |
Family
ID=53178340
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CN201680019723.3A Active CN107407664B (en) | 2015-03-30 | 2016-03-23 | Rotary valve and chromatography system |
Country Status (6)
Country | Link |
---|---|
US (1) | US10746708B2 (en) |
EP (1) | EP3278098B1 (en) |
JP (1) | JP6758660B2 (en) |
CN (1) | CN107407664B (en) |
GB (1) | GB201505421D0 (en) |
WO (1) | WO2016156152A1 (en) |
Families Citing this family (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE102017101633A1 (en) * | 2017-01-27 | 2018-08-02 | Agilent Technologies, Inc. - A Delaware Corporation - | Rotor device for fluid valve with axially offset fluid structure |
DE102017101629A1 (en) * | 2017-01-27 | 2018-08-02 | Agilent Technologies, Inc. - A Delaware Corporation - | Fluid valve with gold-containing and / or platinum-containing coating |
US11680955B2 (en) * | 2018-04-04 | 2023-06-20 | Total Synthesis Ltd. | Fluid diverting module |
US11441978B1 (en) * | 2018-04-12 | 2022-09-13 | Elemental Scientific, Inc. | Automatic evaporative sample preparation |
US11204306B2 (en) * | 2018-08-10 | 2021-12-21 | Elemental Scientific, Inc. | Preconcentration of fluid samples with alternating dual loop introduction |
EP3928010A1 (en) * | 2019-02-20 | 2021-12-29 | F. Hoffmann-La Roche AG | Valve for transferring at least one fluid |
CN114518426B (en) * | 2022-03-03 | 2023-11-03 | 宁波艾纯生物科技有限公司 | Sample injection valve |
Family Cites Families (34)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB1189995A (en) * | 1966-08-09 | 1970-04-29 | Bp Chem Int Ltd | Gas Chromatography Apparatus |
US4068528A (en) * | 1976-01-19 | 1978-01-17 | Rheodyne Incorporated | Two position rotary valve for injecting sample liquids into an analysis system |
DE3367661D1 (en) * | 1982-02-04 | 1987-01-02 | Toray Industries | Rotary valve |
US6000929A (en) * | 1994-03-11 | 1999-12-14 | Daikin Industries, Ltd. | Rotary distribution valve, and regenerative combustion apparatus and regenerative heat exchanger using same |
US5601115A (en) * | 1995-05-31 | 1997-02-11 | Vantege Technologies, Inc. | Multiport sampling valve |
US5803117A (en) | 1996-06-10 | 1998-09-08 | Rheodyne, L.P. | Multi-route full sweep selection valve |
US6012487A (en) * | 1997-03-10 | 2000-01-11 | Brian A. Hauck | Prime purge injection valve or multi-route selections valve |
US6155123A (en) * | 1998-04-17 | 2000-12-05 | Rheodyne, L.P. | Multivalving sample injection system |
US6012488A (en) * | 1998-09-17 | 2000-01-11 | Rheodyne, L.P. | Segmenting valve |
US6161583A (en) * | 1999-06-04 | 2000-12-19 | Morris; Edward J. | Control valve |
US6550496B2 (en) * | 2001-01-16 | 2003-04-22 | General Electric Company | Rotary doser valve |
US6672336B2 (en) * | 2001-11-28 | 2004-01-06 | Rheodyne, Lp | Dual random access, three-way rotary valve apparatus |
US6748975B2 (en) * | 2001-12-26 | 2004-06-15 | Micralyne Inc. | Microfluidic valve and method of manufacturing same |
CN101044346B (en) * | 2004-08-25 | 2010-05-12 | 机械分析公司 | Rotary valve and analytical chromatographic system using the same |
US7823468B2 (en) * | 2007-01-26 | 2010-11-02 | Teledyne Isco, Inc. | Valve |
US8186381B2 (en) * | 2007-02-22 | 2012-05-29 | Ge Healthcare Bio-Sciences Ab | Selection valve |
EP2113081B1 (en) | 2007-02-22 | 2015-11-04 | GE Healthcare Bio-Sciences AB | Rotation valve for sample injection |
JP2008281505A (en) | 2007-05-14 | 2008-11-20 | Japan Aerospace Exploration Agency | Method of resampling 3-dimensional discrete data, and its device |
EP2147302A1 (en) * | 2007-05-15 | 2010-01-27 | GE Healthcare Bio-Sciences AB | Random access rotary valve |
AU2008251098B2 (en) | 2007-05-15 | 2013-11-21 | Ge Healthcare Bio-Sciences Ab | Flow distributing valve |
JP4952795B2 (en) * | 2007-12-17 | 2012-06-13 | 株式会社島津製作所 | Flow path switching valve |
WO2010056189A1 (en) | 2008-11-13 | 2010-05-20 | Ge Healthcare Bio-Sciences Ab | Random access rotary valve |
CN103453179A (en) | 2008-12-10 | 2013-12-18 | 全技术联合公司 | Automated sample injection apparatus, multiport valve, and methods of making and using the same |
AU2009347432B2 (en) * | 2009-06-03 | 2015-01-29 | Agilent Technologies, Inc. | Sample injector with metering device balancing pressure differences in an intermediate valve state |
WO2011027410A1 (en) * | 2009-09-07 | 2011-03-10 | 株式会社島津製作所 | Automatic sampler |
US8459302B2 (en) * | 2009-09-21 | 2013-06-11 | Gulf Sea Ventures LLC | Fluid-directing multiport rotary valve |
JP5646902B2 (en) | 2010-07-26 | 2014-12-24 | アークレイ株式会社 | Liquid chromatography device and injection valve |
US9228982B2 (en) * | 2011-09-16 | 2016-01-05 | Agilent Technologies, Inc. | Single injection valve for HPLC combining sample introduction, wash cycles and diagnosis |
US8960231B2 (en) * | 2011-09-21 | 2015-02-24 | Neil Robert Picha | Multi-mode injection valve |
CN104024847B (en) * | 2011-12-26 | 2017-11-21 | 株式会社岛津制作所 | Flow channel switching valve |
EP3084421B1 (en) * | 2013-12-19 | 2019-02-27 | GE Healthcare Bio-Sciences AB | Chromatography system comprising rotary valves and a feed recirculation flow path |
EP3084420B1 (en) * | 2013-12-19 | 2018-10-17 | GE Healthcare Bio-Sciences AB | Chromatography system comprising a rotary valve and a feed recirculation flow path |
US9541207B1 (en) * | 2014-02-03 | 2017-01-10 | Elemental Scientific, Inc. | Valve assembly with bottom bypass ports |
CN106321896B (en) * | 2016-11-01 | 2018-12-04 | 聊城大学 | A kind of multi-functional chromatography switching valve and its application |
-
2015
- 2015-03-30 GB GBGB1505421.6A patent/GB201505421D0/en not_active Ceased
-
2016
- 2016-03-23 EP EP16711305.9A patent/EP3278098B1/en active Active
- 2016-03-23 WO PCT/EP2016/056404 patent/WO2016156152A1/en active Application Filing
- 2016-03-23 US US15/562,632 patent/US10746708B2/en active Active
- 2016-03-23 CN CN201680019723.3A patent/CN107407664B/en active Active
- 2016-03-23 JP JP2017550107A patent/JP6758660B2/en active Active
Also Published As
Publication number | Publication date |
---|---|
JP2018511801A (en) | 2018-04-26 |
GB201505421D0 (en) | 2015-05-13 |
CN107407664A (en) | 2017-11-28 |
US20180106769A1 (en) | 2018-04-19 |
US10746708B2 (en) | 2020-08-18 |
EP3278098A1 (en) | 2018-02-07 |
EP3278098B1 (en) | 2023-05-17 |
WO2016156152A1 (en) | 2016-10-06 |
JP6758660B2 (en) | 2020-09-23 |
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