CN111148535A - 治疗实体癌和血液癌的组合疗法 - Google Patents

治疗实体癌和血液癌的组合疗法 Download PDF

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Publication number
CN111148535A
CN111148535A CN201880028490.2A CN201880028490A CN111148535A CN 111148535 A CN111148535 A CN 111148535A CN 201880028490 A CN201880028490 A CN 201880028490A CN 111148535 A CN111148535 A CN 111148535A
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seq
amino acid
acid sequence
human
light chain
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Chinese (zh)
Inventor
P·T·曼宁
R·普罗
J·C·阿尔马格罗
R·W·卡尔
B·J·卡波恰
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Anchi Oncology
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Anchi Oncology
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Priority claimed from US15/871,802 external-priority patent/US20180142019A1/en
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    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
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    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]
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CN201880028490.2A 2017-03-22 2018-03-22 治疗实体癌和血液癌的组合疗法 Pending CN111148535A (zh)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US201762475036P 2017-03-22 2017-03-22
US201762475032P 2017-03-22 2017-03-22
US62/475,032 2017-03-22
US62/475,036 2017-03-22
US15/871,802 2018-01-15
US15/871,802 US20180142019A1 (en) 2016-10-21 2018-01-15 Therapeutic cd47 antibodies
PCT/US2018/023860 WO2018175790A1 (en) 2017-03-22 2018-03-22 Combination therapy for the treatment of solid and hematological cancers

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Publication Number Publication Date
CN111148535A true CN111148535A (zh) 2020-05-12

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CN201880028490.2A Pending CN111148535A (zh) 2017-03-22 2018-03-22 治疗实体癌和血液癌的组合疗法

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EP (1) EP3600393A4 (OSRAM)
JP (1) JP7170331B2 (OSRAM)
CN (1) CN111148535A (OSRAM)
AU (1) AU2018240377A1 (OSRAM)
CA (1) CA3057139A1 (OSRAM)
SG (1) SG11201908602UA (OSRAM)
WO (1) WO2018175790A1 (OSRAM)

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Publication number Priority date Publication date Assignee Title
US9221908B2 (en) 2012-12-12 2015-12-29 Vasculox, Inc. Therapeutic CD47 antibodies
BR112015013431A2 (pt) 2012-12-12 2017-11-14 Vasculox Inc anticorpos monoclonais ou respectivos fragmentos ligantes de antígenos, composição farmacêutica, e usos de anticorpo monoclonal ou respectivo fragmento ligante de antígenos
WO2017049251A2 (en) 2015-09-18 2017-03-23 Tioma Therapeutics, Inc. Therapeutic cd47 antibodies
EP3529276A4 (en) 2016-10-21 2020-06-17 Arch Oncology, Inc. CD47 THERAPEUTIC ANTIBODIES
CN113166257B (zh) * 2018-12-03 2023-05-30 上海开拓者生物医药有限公司 Cd47抗体及其制备方法和应用
WO2020232427A2 (en) * 2019-05-16 2020-11-19 Arch Oncology, Inc. Therapeutic compositions and methods for treating cancer in combination with analogs of interleukin proteins
WO2020247820A1 (en) 2019-06-07 2020-12-10 ALX Oncology Inc. Methods and reagents for reducing the interference of drugs that bind cd47 in serological assays
EP4048406A4 (en) * 2019-10-23 2023-11-22 Arch Oncology, Inc. COMBINATION THERAPY FOR THE TREATMENT OF SOLID AND HEMATOLOGICAL MALIGNANT TUMORS
AU2020410410A1 (en) 2019-12-17 2022-06-09 Pfizer Inc. Antibodies specific for CD47, PD-L1, and uses thereof
CN120040592A (zh) * 2020-07-31 2025-05-27 百奥泰生物制药股份有限公司 Cd47抗体及其应用
JP2023552375A (ja) 2020-12-06 2023-12-15 エーエルエックス オンコロジー インコーポレイテッド 血清学的アッセイにおいてｃｄ４７に結合する薬物の干渉を低減するための多量体

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CN101133083A (zh) * 2003-11-11 2008-02-27 中外制药株式会社 人源化的抗cd47抗体
CN104271757A (zh) * 2012-02-06 2015-01-07 印希彼有限责任公司 Cd47抗体及其使用方法
US20160137733A1 (en) * 2012-12-12 2016-05-19 Vasculox Inc. Therapeutic cd47 antibodies
WO2017049251A2 (en) * 2015-09-18 2017-03-23 Tioma Therapeutics, Inc. Therapeutic cd47 antibodies

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CN104548091A (zh) * 2008-02-11 2015-04-29 治疗科技公司 用于肿瘤治疗的单克隆抗体
EP2526118A4 (en) * 2010-01-21 2013-11-13 Immunogen Inc COMPOSITIONS AND METHOD FOR THE TREATMENT OF EGG CANCER
NZ622452A (en) * 2012-06-21 2017-10-27 Compugen Ltd Lsr antibodies, and uses thereof for treatment of cancer
CN105101997B (zh) * 2013-02-06 2018-11-09 印希彼有限合伙公司 不减少血小板和不减少血红细胞的cd47抗体及其使用方法

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CN101133083A (zh) * 2003-11-11 2008-02-27 中外制药株式会社 人源化的抗cd47抗体
CN104271757A (zh) * 2012-02-06 2015-01-07 印希彼有限责任公司 Cd47抗体及其使用方法
US20160137733A1 (en) * 2012-12-12 2016-05-19 Vasculox Inc. Therapeutic cd47 antibodies
WO2017049251A2 (en) * 2015-09-18 2017-03-23 Tioma Therapeutics, Inc. Therapeutic cd47 antibodies

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JESSICA LO 等: "ANTI-CD47 ANTIBODY SUPPRESSES TUMOUR GROWTH AND AUGMENTS THE EFFECT OF CHEMOTHERAPY TREATMENT IN HEPATOCELLULAR CARCINOMA", 《LIVER INTERNATIONAL》 *
XIAOJUAN LIU 等: "CD47 Blockade Triggers T cell-mediated Destruction of Immunogenic Tumors", 《NAT MED.》 *
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AU2018240377A1 (en) 2019-10-31
JP2020511481A (ja) 2020-04-16
JP7170331B2 (ja) 2022-11-14
SG11201908602UA (en) 2019-10-30
WO2018175790A1 (en) 2018-09-27
EP3600393A1 (en) 2020-02-05
EP3600393A4 (en) 2020-12-23
CA3057139A1 (en) 2018-09-27

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