CN111135243A - Chinese yam yang-tonifying solid beverage and preparation method and application thereof - Google Patents

Chinese yam yang-tonifying solid beverage and preparation method and application thereof Download PDF

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CN111135243A
CN111135243A CN201911193281.6A CN201911193281A CN111135243A CN 111135243 A CN111135243 A CN 111135243A CN 201911193281 A CN201911193281 A CN 201911193281A CN 111135243 A CN111135243 A CN 111135243A
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solid beverage
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tonifying
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郑炎
杨法谊
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Beidouxing Quantum Biomedical Technology Shenzhen Co Ltd
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Beidouxing Quantum Biomedical Technology Shenzhen Co Ltd
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Abstract

The application discloses a Chinese yam yang-tonifying solid beverage as well as a preparation method and application thereof. The yam yang-tonifying solid beverage is a solid product obtained by adding purified water and a leavening agent into a traditional Chinese medicine composition and performing anaerobic fermentation; the Chinese medicinal composition comprises radix rehmanniae, radix rehmanniae Preparata, rhizoma Dioscoreae, fructus Lycii, fructus Schisandrae chinensis, semen Cuscutae, Rubi fructus, semen plantaginis, Achyranthis radix, Actinolitum, radix Morindae officinalis, herba Cynomorii, caulis Polygoni Multiflori, Cistanchis herba and HUICHUNCAO; the leaven accounts for 0.005-0.02% of the total weight of the Chinese medicinal composition and the purified water, and comprises cyromazine, copper sulfate, zinc sulfate, ferrous sulfate, cobalt chloride, edible salt, sodium bicarbonate and glucose powder. The Chinese yam yang-tonifying solid beverage adopts a new Chinese medicinal composition formula and combines anaerobic fermentation treatment of a fermentation agent, so that a final product has a better medicinal effect, the treatment effect of sexual dysfunction is improved, and particularly, the Chinese yam yang-tonifying solid beverage has a good treatment effect on impotence and premature ejaculation.

Description

Chinese yam yang-tonifying solid beverage and preparation method and application thereof
Technical Field
The invention relates to the field of Chinese patent medicines, and in particular relates to a Chinese yam yang-tonifying solid beverage as well as a preparation method and application thereof.
Background
Sexual function is a complex physiological process, and researches show that the causes of sexual dysfunction are mainly classified into three types: biological factors, psychosocial factors and cultural factors.
Thus, at present, there are two main treatments for sexual dysfunction, one is psychological grooming, one is drug therapy, or both. In the aspect of traditional Chinese medicines, a plurality of internal or external traditional Chinese medicines or formulas with the function of strengthening yang are proved; for example, "Yiyangchun" in the mercurial and pharmaceutical industries. In addition, there are similar patent applications for the formulation of Chinese medicine for treating sexual dysfunction, such as 201710557763.X, 201810759793.3, etc.
However, the existing Chinese medicinal preparation or Chinese patent medicine has poor treatment effect or has temporary and permanent treatment due to the compatibility of medicines, and the sexual dysfunction is difficult to be effectively cured.
Disclosure of Invention
The application aims to provide a Chinese yam yang-tonifying solid beverage for treating sexual dysfunction and a preparation method and application thereof.
In order to achieve the purpose, the following technical scheme is adopted in the application:
the first aspect of the application discloses a Chinese yam yang-tonifying solid beverage, which is a solid product obtained by adding purified water and a leaven into a Chinese medicinal composition and performing anaerobic fermentation; wherein the Chinese medicinal composition comprises radix rehmanniae, radix rehmanniae Preparata, rhizoma Dioscoreae, fructus Lycii, fructus Schisandrae chinensis, semen Cuscutae, Rubi fructus, semen plantaginis, Achyranthis radix, Actinolitum, radix Morindae officinalis, herba Cynomorii, caulis Polygoni Multiflori, Cistanchis herba and herba Huochidionis Carbonisatus; the leaven accounts for 0.005-0.02% of the total weight of the traditional Chinese medicine composition and the pure water, and consists of 0.02-0.03 part of cyromazine, 0.2-0.4 part of copper sulfate, 0.6-0.8 part of zinc sulfate, 0.3-0.6 part of ferrous sulfate, 0.6-0.7 part of cobalt chloride, 0.1-0.2 part of edible salt, 0.3-0.4 part of baking soda and 0.5-1.5 parts of glucose powder.
The yam yang-tonifying solid beverage is also called yang-tonifying spring, wherein the dried rehmannia root is used for treating yin deficiency fever, diabetes, hematemesis, epistaxis, metrorrhagia, irregular menstruation, threatened abortion and yin injury constipation; rehmanniae radix Preparata has effects of replenishing blood, nourishing, replenishing essence, and replenishing marrow, and can be used for treating blood deficiency, sallow complexion, giddiness, cardiopalmus, menoxenia, metrorrhagia, liver and kidney yin deficiency, hectic fever, night sweat, spermatorrhea, sexual impotence, infertility, metrorrhagia, leg weakness, tinnitus, deafness, dim eyesight, gray hair, diabetes, constipation, kidney essence deficiency, and dyspnea; the Chinese yam has the effects of lubricating and moistening, so that the Chinese yam can benefit lung qi, nourish lung yin, treat chronic cough due to lung deficiency and phlegm and prevent cardiovascular diseases, contains almost no fat, contains mucin which can prevent fat deposition of a cardiovascular system and prevent premature hardening of arteries, contains saponin which can reduce cholesterol and triglyceride, and has the improvement effect on diseases such as hypertension and hyperlipidemia; the medicinal function of the medlar is the same as that of Ningxia medlar; fructus Schisandrae chinensis has effects of astringing lung, replenishing kidney essence, promoting fluid production, arresting sweating, astringing essence, treating lung deficiency, asthma and cough, dry mouth, thirst, spontaneous perspiration, night sweat, fatigue, emaciation, nocturnal emission, chronic diarrhea and chronic dysentery; semen Cuscutae can be used for treating kidney-yin and yang deficiency syndrome such as lumbago due to kidney deficiency, sexual impotence, spermatorrhea, pollakisuria, infertility due to cold womb, dim eyesight, and loose stool; rubi fructus has effects of invigorating kidney, stopping nocturnal emission, reducing urination, nourishing liver, and improving eyesight, and can be used for treating spermatorrhea, enuresis, frequent micturition, sexual impotence, premature ejaculation, dim eyesight; semen plantaginis has effects of promoting diuresis, clearing heat, improving eyesight, eliminating phlegm, treating dysuria, stranguria with turbid urine, leukorrhagia, hematuria, summer-heat damp diarrhea dysentery, cough with excessive phlegm, damp arthralgia, conjunctival congestion and nebula; achyranthes bidentata tonifies liver and kidney, strengthens bones and muscles, activates blood and promotes menstruation, induces fire (blood) to descend, induces diuresis and treats stranguria, and is used for treating soreness and pain of waist and knees, flaccidity and weakness of lower limbs, blood stagnation and amenorrhea, dysmenorrhea, postpartum blood stasis and abdominal pain, abdominal mass, retained afterbirth, heat stranguria, stranguria with blood, traumatic injury, carbuncle swelling and sore throat; actinolitum can be used for treating kidney yang deficiency, sexual impotence, spermatorrhea, premature ejaculation, soreness of waist and knees, infertility due to cold womb, leukorrhagia, abdominal mass, and metrorrhagia; morinda officinalis tonifies and dispels wind; the cynomorium songaricum can tonify kidney, replenish vital essence and moisten dryness, is mainly used for treating impotence and spermatorrhea, soreness and weakness of waist and knees, constipation due to intestinal dryness, and has certain effects on paralysis and improvement of sexual dysfunction; caulis Polygoni Multiflori can be used for treating insomnia, dreaminess, blood deficiency, body pain, skin numbness, rheumatalgia, and rubella pruritus; cistanchis herba has effects of invigorating kidney yang, replenishing essence and blood, and moistening intestine, and can be used for treating kidney yang deficiency, essence deficiency, sexual impotence, spermatorrhea, whitish and turbid urine, pollakisuria, lumbago, asthenia, tinnitus, blurred vision, menorrhea, infertility due to cold womb, and constipation due to intestinal dryness; the herba Huichun Scandentis has effects of nourishing yin, invigorating kidney, strengthening tendons and bones, and enhancing immunity.
The Chinese yam yang-tonifying solid beverage prepared by optimizing the formula of the Chinese medicinal composition and combining the fermentation effect of the leaven can better exert the drug effect, so that the Chinese yam yang-tonifying solid beverage has better treatment effects on sexual dysfunction such as impotence and premature ejaculation. The leaven is a compound preparation which is specially developed by the application and can promote the growth and fermentation of environmental microorganisms carried by the traditional Chinese medicine composition; the anaerobic fermentation by adopting the composite preparation has the following effects: (1) heavy metal and pesticide residue contained in the medicinal materials can be decomposed and converted, and the problems that the heavy metal of the Chinese medicinal materials exceeds the standard and the pesticide residue is remained due to soil pollution or pesticide residue exceeding the standard in the planting process are solved; (2) through fermentation, the effective active ingredients of the Chinese medicinal materials of all the components can be fully released and organically combined together, and the common effect of mutual compatibility of all the components is really achieved, so that the treatment effect is improved; (3) through the fermentation of the leaven, the content of probiotics carried by the traditional Chinese medicine composition can be increased, the content of prebiotics is increased, the toxic and side effects in the taking process can be reduced under the action of the probiotics and the prebiotics, and the harm to the human body is avoided.
Preferably, the Chinese medicinal composition consists of 50 parts by weight of radix rehmanniae recen, 50 parts by weight of prepared rehmannia root, 100 parts by weight of Chinese yam, 40 parts by weight of medlar, 40 parts by weight of schisandra chinensis, 40 parts by weight of semen cuscutae, 40 parts by weight of raspberry, 40 parts by weight of plantain seed, 30 parts by weight of achyranthes root, 30 parts by weight of actinolite, 30 parts by weight of morinda officinalis, 30 parts by weight of cynomorium songaricum, 60.
Preferably, the amount of purified water added to the Chinese medicinal composition is 30L per 50g of dried rehmannia root.
It is to be noted that the weight parts of the components in the traditional Chinese medicine composition and the amount of purified water added correspondingly are only the formula dosage specifically adopted in one implementation manner of the application; it is understood that the above amount can be adjusted as appropriate according to the specific situation, for example, the amount of each component can be increased or decreased by about 5%. The pure water is used for fully mixing and fermenting all the components; the pure water consumption is too low, and the components cannot be mixed, so that the mixing is not uniform, the performance of the compatibility drug property is influenced, or the drug property is unstable and nonuniform; if the amount of the purified water is too high, the common properties of the components are difficult to organically combine together through fermentation, and the drug effect is also influenced.
Preferably, the anaerobic fermentation is performed at low temperature for 5-15 days.
The aim of low-temperature fermentation is to avoid the influence of high temperature on the drug effect; on the other hand, low temperature fermentation is beneficial to the growth of probiotics. As regards the number of days of fermentation, it is mainly the organic combination of the components and the contents of probiotics and prebiotics that are affected; it will be appreciated that too short a fermentation time will not achieve the desired effect, and that too long a fermentation time will be time consuming, and that part of the drug or prebiotic will be consumed by the probiotic, which will itself enter the stationary or decline phase of growth.
Preferably, the low temperature is 40-50 ℃.
The application also discloses application of the Chinese yam yang-tonifying solid beverage in preparation of a medicament for treating sexual dysfunction.
In another aspect of the present application, a pharmaceutical composition for treating sexual dysfunction, which comprises the effective active ingredient of the yam yang-tonifying solid beverage of the present application, is disclosed.
The yam yang-tonifying solid beverage has the advantages that the formula of the yam yang-tonifying solid beverage has the effect of treating sexual dysfunction, and the efficacy of the yam yang-tonifying solid beverage can be more effectively exerted by combining with fermentation of the leavening agent, so that the yam yang-tonifying solid beverage can be used for treating the sexual dysfunction or prepared into corresponding treatment medicines.
Preferably, the pharmaceutical composition of the present application further comprises pharmaceutically acceptable adjuvants or auxiliary components.
The pharmaceutically acceptable auxiliary materials or auxiliary components mainly refer to glucose, lactose, sucrose, starch, mannitol, dextrin, fatty glyceride, polyethylene glycol, hydroxyethyl starch, ethylene glycol, polyoxyethylene sorbitan fatty acid ester, amino acid, gelatin, albumin, water, physiological saline and the like, and the yam yang-tonifying solid beverage is prepared into medicines in various dosage forms; or, the powdery Chinese yam yang-tonifying solid beverage can be directly adopted without using the auxiliary materials or the auxiliary components. The dosage form of the pharmaceutical composition may be any dosage form, and is not particularly limited.
The application further discloses a preparation method of the Chinese yam yang-tonifying solid beverage, which comprises the following steps:
(1) weighing radix rehmanniae, radix rehmanniae Preparata, rhizoma Dioscoreae, fructus Lycii, fructus Schisandrae chinensis, semen Cuscutae, Rubi fructus, semen plantaginis, Achyranthis radix, Actinolitum, radix Morindae officinalis, herba Cynomorii, caulis Polygoni Multiflori, Cistanchis herba and herba Huochiensis by weight, and processing into powder; wherein, each component is dry medicinal materials;
(2) uniformly dispersing the powder material in the step (1) into purified water at 55-65 ℃, adding a leavening agent, uniformly stirring, and carrying out anaerobic fermentation at a constant temperature of 40-50 ℃ for 5-15 days in a sealed environment;
(3) and (3) drying and crushing the fermentation product obtained in the step (2) to obtain the Chinese yam yang-tonifying solid beverage.
In the preparation method, the components are processed into powder in the step (1) for the purpose of facilitating fermentation and better exerting the drug effect; in one implementation of the present application, the particle size of the powder is 145-155 mesh, preferably 150 mesh.
Preferably, the drying temperature in the step (3) is 50-55 ℃.
It should be noted that the drying is mainly for removing moisture, but not for affecting the efficacy of the drug at too high a temperature, and therefore, it is preferably 50 to 55 ℃.
Preferably, in the preparation method of the application, the leaven is prepared by adopting the following method,
(1) carrying out heat treatment dehydration on cyromazine, copper sulfate, zinc sulfate, ferrous sulfate and cobalt chloride respectively;
(2) mixing the heat-treated and dehydrated cyromazine, copper sulfate, zinc sulfate, ferrous sulfate and cobalt chloride with salt, glucose powder and sodium bicarbonate according to weight percentage, and grinding to prepare mixed powder;
(3) and (3) drying the mixed powder in the step (2) under the conditions of no oxygen and light shielding to obtain the leavening agent.
Preferably, in step (1), the dehydration by heat treatment is carried out under oxygen-free conditions.
Preferably, in the step (1), the heat treatment dehydration condition of cyromazine is 140-150 ℃ for 100-120 minutes, the heat treatment dehydration condition of copper sulfate is 85-95 ℃ for 75-85 minutes, the heat treatment dehydration condition of zinc sulfate is 95-100 ℃ for 100-120 minutes, the heat treatment dehydration condition of ferrous sulfate is 100-120 ℃ for 60-70 minutes, and the heat treatment dehydration condition of cobalt chloride is 135-145 ℃ for 140-150 minutes.
Preferably, in the step (2), the particle size of the mixed powder is 300 meshes.
Preferably, in the step (3), the drying condition is 55-65 ℃ for 30-35 hours.
The beneficial effect of this application lies in:
the Chinese yam yang-tonifying solid beverage adopts a new Chinese medicinal composition formula and combines anaerobic fermentation treatment of a fermentation agent, so that a final product has a better medicinal effect, the treatment effect of sexual dysfunction is improved, and particularly, the Chinese yam yang-tonifying solid beverage has a good treatment effect on impotence and premature ejaculation.
Detailed Description
In view of the problems of poor treatment effect of the traditional Chinese medicine preparation for treating sexual dysfunction and the like, the inventor develops a new traditional Chinese medicine composition capable of better treating sexual dysfunction according to years of traditional Chinese medicine practice experience and practice; in combination with the principle of environmental microbial preparation, a new leaven is developed to carry out anaerobic fermentation on the formula of the traditional Chinese medicine composition; thereby obtaining the yam yang-tonifying solid beverage. The yam yang-tonifying solid beverage is a solid product obtained by adding purified water and a leavening agent into a traditional Chinese medicine composition and performing anaerobic fermentation, namely removing water in the Chinese yam yang-tonifying solid beverage after the anaerobic fermentation.
Wherein, the purified water refers to water without impurities or bacteria, and is called purified water or purified water for short; the purpose of using purified water is to avoid the introduction of other interfering components by the water. The important innovation of the application is that firstly, a new traditional Chinese medicine composition formula is adopted; second, a special starter for activating the growth of microorganisms is used. The leaven is obtained by long-term and deep research and optimization of the inventor, mainly comprises some conventional chemical agents, has small dosage, can quickly activate a large amount of probiotics such as the original lactic acid bacteria in the traditional Chinese medicine composition, does not need to additionally add beneficial bacteria, and has low cost.
In order to improve the effect of the leavening agent for activating the growth of microorganisms, the leavening agent is prepared by a special preparation method. Specifically, the method comprises the following steps:
(1) carrying out heat treatment dehydration on cyromazine, copper sulfate, zinc sulfate, ferrous sulfate and cobalt chloride respectively;
(2) mixing the heat-treated and dehydrated cyromazine, copper sulfate, zinc sulfate, ferrous sulfate and cobalt chloride with salt, glucose powder and sodium bicarbonate according to weight percentage, and grinding to prepare mixed powder;
(3) drying the mixed powder in the step (2) under the conditions of no oxygen and light shielding to obtain the leavening agent;
wherein, in the step (1), the heat treatment dehydration is carried out under the anaerobic condition; the heat treatment dehydration condition of the cyromazine is 140-150 ℃ for 100-120 minutes, the heat treatment dehydration condition of the copper sulfate is 85-95 ℃ for 75-85 minutes, the heat treatment dehydration condition of the zinc sulfate is 95-100 ℃ for 100-120 minutes, the heat treatment dehydration condition of the ferrous sulfate is 100-120 ℃ for 60-70 minutes, and the heat treatment dehydration condition of the cobalt chloride is 135-145 ℃ for 140-150 minutes; in the step (2), the particle size of the mixed powder is 300 meshes; in the step (3), the drying condition is that the treatment is carried out for 30 to 35 hours at the temperature of between 55 and 65 ℃.
In the starter, cyromazine is a disinfectant and harmless to people, and the weak disinfection function is kept after the treatment by the preparation method, so that aspergillus flavus and other harmful bacteria in the traditional Chinese medicine composition can be inhibited; and the beneficial bacteria such as lactic acid bacteria are dominant in quantity, so that the cyromazine does not influence the growth of the beneficial bacteria such as lactic acid bacteria, but rapidly grows under the activation of the leavening agent. Other components are dehydrated through special heat treatment, so that the toxicity is reduced, and the components are combined with each other to play a role in promoting the growth of probiotics in the traditional Chinese medicine composition.
The present application will be described in further detail with reference to specific examples. The following examples are intended to be illustrative of the present application only and should not be construed as limiting the present application.
Examples
Firstly, preparation of leaven
10g of cyromazine, copper sulfate, zinc sulfate, ferrous sulfate and cobalt chloride are weighed respectively. The preparation method comprises the following steps of carrying out heat treatment dehydration on cyromazine in an oven at the temperature of 145 ℃ for 110 minutes, carrying out heat treatment dehydration on copper sulfate in the oven at the temperature of 90 ℃ for 80 minutes, carrying out heat treatment dehydration on zinc sulfate in the oven at the temperature of 95 ℃ for 110 minutes, carrying out heat treatment dehydration on ferrous sulfate in the oven at the temperature of 110 ℃ for 65 minutes, and carrying out heat treatment dehydration on cobalt chloride in the oven at the temperature of 140 ℃ for 145 minutes.
Weighing 0.3g of heat-treated and dehydrated cyromazine, 4g of heat-treated and dehydrated copper sulfate, 8g of heat-treated and dehydrated zinc sulfate, 5g of heat-treated and dehydrated ferrous sulfate and 7g of heat-treated and dehydrated cobalt chloride, weighing 2g of edible salt, 4g of baking soda and 12g of glucose powder, uniformly mixing the components, sufficiently grinding by using a mortar, and sieving by using a 300-mesh sieve. Then, the sieved powder mixture was subjected to oxygen-barrier and light-shielding drying in an oven at 65 ℃ for 32 hours to obtain a fermentation agent of this example.
Preparation of Chinese yam and Chinese yam yang-tonifying solid beverage
Weighing 50g of radix rehmanniae recen, 50g of prepared rehmannia root, 100g of Chinese yam, 40g of medlar, 40g of Chinese magnoliavine fruit, 40g of Chinese dodder seed, 40g of raspberry, 40g of plantain seed, 30g of achyranthes root, 30g of actinolite, 30g of morinda officinalis, 30g of cynomorium songaricum, 60g of tuber fleeceflower stem, 60g of cistanche and 100g of rejuvenation grass, and processing the components into 150-mesh powder; mixing the powder materials, placing the powder materials in a container, adding 30L of purified water with the temperature of 60 ℃, uniformly stirring the mixture, adding 6g of prepared leavening agent, uniformly stirring the mixture, placing the mixture in a sealed container, carrying out anaerobic constant-temperature fermentation for 9 days at the temperature of 48 ℃, after the fermentation is finished, drying the mixture at the low temperature of 50 ℃, and crushing the mixture to obtain the Chinese yam yang-tonifying solid beverage. The markers were labeled as test groups.
Preparation of comparative test material without addition of leaven
The process was carried out according to the recipe and fermentation procedure for "preparation of solid beverage with tonifying yang from yam", except that no starter was added, and the final prepared solid product was labeled as comparative test 1.
Preparation of comparative test material of pure traditional Chinese medicine composition
According to the formula of 'preparation of Chinese yam yang-tonifying solid beverage', the components are directly weighed, processed into 150-mesh powder and uniformly mixed to serve as a comparative experiment 2.
Fifth, test of drug action
In this example, 60 impotence patients and 60 premature ejaculation patients were treated, and all patients signed an informed consent according to the relevant regulations.
Patients with different diseases were divided equally into three groups, 20 per group:
the first group, 20 impotence patients, 20 premature ejaculation patients; before sexual life, the second Chinese yam yang-tonifying solid drink prepared from the second Chinese yam yang-tonifying solid drink is taken 30min in advance, and is marked as a test group.
Second group, 20 impotence patients, 20 premature ejaculation patients; before sexual life, the traditional Chinese medicine 'three, prepared by contrast test material without leaven' is taken 30min in advance, and is marked as contrast test 1.
Third group, 20 impotence patients, 20 premature ejaculation patients; before sexual life, the traditional Chinese medicine prepared from the comparative test material of the four-pure traditional Chinese medicine composition is taken 30min in advance, and is marked as comparative test 2.
The judgment standard of the treatment effect is as follows:
the method has the following advantages: for impotence patients, normal erection can be performed, and normal sexual life is performed; for premature ejaculation sufferers, normal sexual life can be continuously carried out.
And (4) invalidation: no obvious improvement after taking.
The statistical results of the three groups of tests are as follows:
the first group of 20 impotence patients and 20 premature ejaculation patients can have normal sexual life after taking the yam yang-tonifying solid beverage.
2 of the 20 impotence patients in the second group were not effective, the rest were all effective; of the 20 premature ejaculation patients, 1 was ineffective and the others were effective.
In the third group, 1 of 20 patients with impotence was ineffective, and the others were all effective; of the 20 premature ejaculation patients, 1 was ineffective and the others were effective.
In addition, in experimental design, the dosage of the yam yang-tonifying solid beverage is obviously lower than that of other groups, because the effect is poorer when the dosage of 1g is also adopted in other groups, and therefore, the dosages of the second group and the third group are properly increased according to experience. The results show that the Chinese yam yang-tonifying solid beverage has less dosage and better treatment effect, and the traditional Chinese medicine composition without fermentation has poor effect. In general, the traditional Chinese medicine composition has a treatment effect on sexual dysfunction, and the yam yang-tonifying solid beverage prepared by the traditional Chinese medicine composition has a better treatment effect after anaerobic fermentation by using a fermentation agent.
The foregoing is a more detailed description of the present application in connection with specific embodiments thereof, and it is not intended that the present application be limited to the specific embodiments thereof. It will be apparent to those skilled in the art from this disclosure that many more simple derivations or substitutions can be made without departing from the spirit of the disclosure.

Claims (10)

1. The Chinese yam yang-tonifying solid beverage is characterized in that: the Chinese yam yang-tonifying solid beverage is a solid product obtained by adding purified water and a leavening agent into a Chinese medicinal composition and performing anaerobic fermentation;
the traditional Chinese medicine composition is prepared from radix rehmanniae recen, prepared rehmannia root, Chinese yam, medlar, Chinese magnoliavine fruit, south dodder seed, raspberry, plantain seed, twotooth achyranthes root, actinolite, morinda officinalis, cynomorium songaricum, tuber fleeceflower stem, desertliving cistanche and Chinese ilex;
the leaven accounts for 0.005-0.02% of the total weight of the traditional Chinese medicine composition and the purified water, and consists of 0.02-0.03 part of cyromazine, 0.2-0.4 part of copper sulfate, 0.6-0.8 part of zinc sulfate, 0.3-0.6 part of ferrous sulfate, 0.6-0.7 part of cobalt chloride, 0.1-0.2 part of edible salt, 0.3-0.4 part of baking soda and 0.5-1.5 parts of glucose powder.
2. The yam yang-tonifying solid beverage according to claim 1, which is characterized in that: the traditional Chinese medicine composition comprises, by weight, 50 parts of radix rehmanniae recen, 50 parts of prepared rehmannia root, 100 parts of Chinese yam, 40 parts of wolfberry fruit, 40 parts of schisandra chinensis, 40 parts of semen cuscutae, 40 parts of raspberry, 40 parts of plantain seed, 30 parts of achyranthes bidentata, 30 parts of actinolite, 30 parts of morinda officinalis, 30 parts of cynomorium songaricum, 60 parts of tuber fleeceflower stem, 60 parts of cistanche and 100 parts of veronic.
3. The yam yang-tonifying solid beverage according to claim 2, wherein: the amount of purified water added to the traditional Chinese medicine composition is that 30L of purified water is added to every 50g of radix rehmanniae recen.
4. The yam yang-tonifying solid beverage according to any one of claims 1 to 3, wherein: the anaerobic fermentation condition is low-temperature fermentation for 5-15 days;
preferably, the low temperature is 40-50 ℃.
5. Use of the yam yang-tonifying solid beverage according to any one of claims 1 to 4 in the preparation of a medicament for treating sexual dysfunction.
6. A pharmaceutical composition for treating sexual dysfunction, comprising: the effective active ingredient of the pharmaceutical composition is the Chinese yam yang-tonifying solid beverage as claimed in any one of claims 1 to 4.
7. The pharmaceutical composition of claim 6, wherein: the pharmaceutical composition also comprises pharmaceutically acceptable auxiliary materials or auxiliary components.
8. The preparation method of the yam yang-tonifying solid beverage according to any one of claims 1 to 4, wherein: comprises the following steps of (a) carrying out,
(1) weighing radix rehmanniae, radix rehmanniae Preparata, rhizoma Dioscoreae, fructus Lycii, fructus Schisandrae chinensis, semen Cuscutae, Rubi fructus, semen plantaginis, Achyranthis radix, Actinolitum, radix Morindae officinalis, herba Cynomorii, caulis Polygoni Multiflori, Cistanchis herba and herba Huichi Scandentis according to weight parts, and processing into powder;
(2) uniformly dispersing the powder material obtained in the step (1) into purified water at the temperature of 55-65 ℃, adding the leavening agent, uniformly stirring, and carrying out anaerobic fermentation at the constant temperature of 40-50 ℃ for 5-15 days in a sealed environment;
(3) and (3) drying and crushing the fermentation product obtained in the step (2) to obtain the Chinese yam yang-tonifying solid beverage.
9. The method of claim 8, wherein: the particle size of the powder in the step (1) is 145-155 meshes;
preferably, the drying temperature in the step (3) is 50-55 ℃.
10. The production method according to claim 8 or 9, characterized in that: the leavening agent is prepared by adopting the following method,
(1) carrying out heat treatment dehydration on cyromazine, copper sulfate, zinc sulfate, ferrous sulfate and cobalt chloride respectively;
(2) mixing the heat-treated and dehydrated cyromazine, copper sulfate, zinc sulfate, ferrous sulfate and cobalt chloride with salt, glucose powder and sodium bicarbonate according to weight percentage, and grinding to prepare mixed powder;
(3) drying the mixed powder in the step (2) under the conditions of no oxygen and light shielding to obtain the leavening agent;
preferably, in the step (1), the heat treatment dehydration is carried out under the anaerobic condition;
preferably, in the step (1), the heat treatment dehydration condition of cyromazine is 140-150 ℃ for 100-120 minutes, the heat treatment dehydration condition of copper sulfate is 85-95 ℃ for 75-85 minutes, the heat treatment dehydration condition of zinc sulfate is 95-100 ℃ for 100-120 minutes, the heat treatment dehydration condition of ferrous sulfate is 100-120 ℃ for 60-70 minutes, and the heat treatment dehydration condition of cobalt chloride is 135-145 ℃ for 140-150 minutes;
preferably, in the step (2), the particle size of the mixed powder is 300 meshes;
preferably, in the step (3), the drying condition is 55-65 ℃ for 30-35 hours.
CN201911193281.6A 2019-11-28 2019-11-28 Chinese yam yang-tonifying solid beverage and preparation method and application thereof Withdrawn CN111135243A (en)

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Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN116251162A (en) * 2022-12-26 2023-06-13 刘进国 Traditional Chinese medicine composition for treating abdominal pain and diarrhea, preparation and traditional Chinese medicine plaster

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN116251162A (en) * 2022-12-26 2023-06-13 刘进国 Traditional Chinese medicine composition for treating abdominal pain and diarrhea, preparation and traditional Chinese medicine plaster
CN116251162B (en) * 2022-12-26 2024-01-26 刘进国 Traditional Chinese medicine composition for treating abdominal pain and diarrhea, preparation and traditional Chinese medicine plaster

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Application publication date: 20200512