CN111134756B - Fibrous chronic embolism device for preventing ectopic embolism - Google Patents

Fibrous chronic embolism device for preventing ectopic embolism Download PDF

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CN111134756B
CN111134756B CN201911399516.7A CN201911399516A CN111134756B CN 111134756 B CN111134756 B CN 111134756B CN 201911399516 A CN201911399516 A CN 201911399516A CN 111134756 B CN111134756 B CN 111134756B
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embolization
embolism
linear
agent
chronic
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CN111134756A (en
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蒋安
周蕊
李宗芳
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Xian Jiaotong University
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Xian Jiaotong University
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
    • A61B17/12—Surgical instruments, devices or methods, e.g. tourniquets for ligaturing or otherwise compressing tubular parts of the body, e.g. blood vessels, umbilical cord
    • A61B17/12022—Occluding by internal devices, e.g. balloons or releasable wires
    • A61B17/12027—Type of occlusion
    • A61B17/12031—Type of occlusion complete occlusion
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
    • A61B17/12—Surgical instruments, devices or methods, e.g. tourniquets for ligaturing or otherwise compressing tubular parts of the body, e.g. blood vessels, umbilical cord
    • A61B17/12022—Occluding by internal devices, e.g. balloons or releasable wires
    • A61B17/12099—Occluding by internal devices, e.g. balloons or releasable wires characterised by the location of the occluder
    • A61B17/12109—Occluding by internal devices, e.g. balloons or releasable wires characterised by the location of the occluder in a blood vessel
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
    • A61B17/12—Surgical instruments, devices or methods, e.g. tourniquets for ligaturing or otherwise compressing tubular parts of the body, e.g. blood vessels, umbilical cord
    • A61B17/12022—Occluding by internal devices, e.g. balloons or releasable wires
    • A61B17/12131—Occluding by internal devices, e.g. balloons or releasable wires characterised by the type of occluding device
    • A61B17/12159—Solid plugs; being solid before insertion
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
    • A61L31/005—Ingredients of undetermined constitution or reaction products thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
    • A61L31/04—Macromolecular materials
    • A61L31/048—Macromolecular materials obtained by reactions only involving carbon-to-carbon unsaturated bonds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
    • A61L31/04—Macromolecular materials
    • A61L31/06—Macromolecular materials obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
    • A61L31/08—Materials for coatings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
    • A61L31/14—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L31/16—Biologically active materials, e.g. therapeutic substances
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L33/00—Antithrombogenic treatment of surgical articles, e.g. sutures, catheters, prostheses, or of articles for the manipulation or conditioning of blood; Materials for such treatment
    • A61L33/0005—Use of materials characterised by their function or physical properties
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M31/00—Devices for introducing or retaining media, e.g. remedies, in cavities of the body

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Abstract

The invention discloses a fiber chronic embolism device for preventing ectopic embolism, which comprises a linear embolic agent, a conveying pipe and an injection pipe, wherein the linear embolic agent is arranged in the conveying pipe, the rear end of the conveying pipe is connected with an outlet of the injection pipe, the conveying pipe comprises a connecting part, a containing part and an output part, the front end and the rear end of the conveying pipe are provided with sealing caps, the two ends of the containing part are respectively connected with the output part and the connecting part, the connecting part is connected with the output end of the injection pipe, and the rear end of the injection pipe is provided with a pressurizing device; the invention designs the embolic agent into one or a bundle of long filamentous structures, the filaments fill the blood vessel after being injected into the blood vessel, blood flow still passes in a short period, and the blood flow is gradually and completely blocked along with the gradual formation of the thrombus attached by the filaments, thereby forming the effect of chronic embolism; the filaments are dragged to be intertwined with each other, so that ectopic embolism is prevented, and acute ischemic necrosis of the tissue is avoided.

Description

Fibrous chronic embolism device for preventing ectopic embolism
Technical Field
The invention belongs to the field of medical instruments, and particularly relates to a fibrous chronic embolism device for preventing ectopic embolism.
Background
The method of embolizing blood vessels is commonly used in interventional or surgical operations to treat diseases such as tumors and blood vessels, and the traditional embolization agents are iodized oil, biological glue, gelatin sponge and the like. The embolic agent completely blocks blood flow after entering blood vessels, so that ischemic necrosis of embolized parts is caused, meanwhile, embolic materials are likely to be washed and shed by the blood flow to form emboli, and the emboli enters the parts such as lungs, brains, limbs and the like along with the blood flow, so that fatal risks such as pulmonary embolism, cerebral embolism, limb gangrene and the like are caused. With the expansion of embolization technology, vascular embolization has also been applied to non-neoplastic diseases to reduce organ blood flow and modulate organ function. This requires chronic ischemia at the embolization site and sufficient ischemia compensation time for the organ to avoid acute ischemic necrosis. In addition, it is desirable that the embolic agent be localized to the site of embolization to avoid ectopic embolization. This is difficult to meet with current embolic agents.
Disclosure of Invention
In order to solve the problems in the prior art, the invention discloses a fiber chronic embolism device for preventing ectopic embolism, which is characterized in that an embolism material is designed into one or more bundles of long filament-shaped structures, the filaments fill the blood vessel after being injected into the blood vessel, but blood flow still passes through gaps among the filaments, thrombus is slowly formed in the gaps to gradually block the gaps, the effect of chronic embolism is caused, acute ischemic necrosis of tissue organs is avoided, and all parts of the long filament-shaped embolism are connected into a whole and cannot fall off locally to form ectopic embolism.
In order to achieve the purpose, the invention adopts the technical scheme that the fibrous chronic embolism device for preventing ectopic embolism comprises a linear embolic agent, a delivery pipe and an injection pipe, wherein the linear embolic agent is arranged in the delivery pipe, and two ends of the delivery pipe are respectively provided with a detachable sealing cap; during the use, the rear end of conveyer pipe is opened and is connected the export of injection syringe, and the conveyer pipe includes connecting portion, holds and deposit portion and output portion, holds the both ends of depositing the portion and connect output portion and connecting portion respectively, and connecting portion are connected with the output of injection syringe, and the rear end of injection syringe is provided with pressure device.
The diameter of holding portion and connecting portion is greater than the diameter of output portion, holds the diameter of portion to output portion and reduces gradually, and the outside of connecting portion is provided with handheld ear.
The pressurizing device is a medical pulse pump, and the output end of the medical pulse pump is connected with the inlet of the injection tube.
The thread-like embolic agent is in the shape of a spiral, a chain, a single thread or a multi-thread along the length direction.
The front end of the linear embolic agent is divided into a plurality of strands, and the strands are coated with an anticoagulant coating or a coagulation promoting coating.
The surface of the linear embolic agent is provided with capillary fibers formed by polishing.
The linear embolic agent is made of polyethylene, silk, nylon, polyglycolic acid or synthetic polyester.
The diameter of the linear embolic agent is less than 1 mm.
The rear end of the linear plugging agent is provided with a chuck.
The containing part is filled with a pushing preservation liquid.
Compared with the prior art, the invention has at least the following beneficial effects: the invention designs the embolic agent into a bundle of long filamentous structures, the filaments fill the blood vessel after being injected into the blood vessel, blood flow still passes in a short period, and the blood flow is gradually and completely blocked along with the gradual formation of the attached thrombus of the filaments, thereby forming the effect of chronic embolism; in addition, because the filaments are dragged with each other, the whole embolic agent is a whole, and each fiber of the filaments is intertwined with each other, so that the occurrence of ectopic embolism is prevented; the whole fiber is biologically inert and non-degradable, can be developed under X-ray, has small diameter and good flexibility, and can enter blood vessels, small blood vessels, capillary vessels or blood sinuses along with pressure; the long filamentous fibers allow blood to pass through, and thrombus is gradually formed on the filaments, so that chronic ischemia of an embolism position is caused, and acute ischemic necrosis of tissues is avoided.
Further, the diameters of the storage portion and the connecting portion are larger than the diameter of the output portion, the diameters from the storage portion to the output portion gradually decrease, and the pressure of the output portion instantaneously increases, which contributes to making the linear plugging agent quickly reach a specified position.
Furthermore, the linear embolization agent is spiral, chain, single-strand or multi-strand in the length direction, and forms spiral embolization under the action of pressure and vascular resistance, so that the embolization time is short, the embolization effect is good, and the embolization is not easy to displace.
Furthermore, the linear embolizing agent is made of non-absorbable materials such as polyethylene, silk or nylon, and can be used as permanent embolization, and can be absorbed by human body by polyglycolic acid or synthetic polyester, and disappears after embolization.
Further, the thickness of the filamentous embolic agent depends on the thickness of the embolized blood vessel, and the thicker the embolized blood vessel, the thicker the filamentous embolic agent, and the thinner the embolized blood vessel or the closer the embolized site is required to the capillary vessel, the thinner the filamentous embolic agent.
Furthermore, according to the speed of chronic embolism of the embolized part, smooth filamentous embolization agents and filamentous embolization agents with different plush degrees can be selected, the slower embolization is needed, the smooth filamentous embolization agents are selected, if the embolization is needed to be faster, the outer surfaces of the filamentous embolization agents are polished to form capillary fibers to form a plush external structure, and the more obvious the plush degree is, the shorter the embolization time is.
Furthermore, the tail end of the filamentous embolic agent is provided with a chuck which can be used for fixing the position of the filamentous embolic agent, further preventing the filamentous embolic agent from shifting and being taken out at any time.
Further, the front end of the linear embolic agent is coated with an anticoagulation coating or a coagulation promoting coating, so that it can prevent blood from attaching and coagulating or promote rapid coagulation of attached blood in the blood vessel.
Furthermore, the containing part is filled with pushing preservation liquid which is beneficial to forward pushing of the embolus.
Drawings
FIG. 1 is a schematic diagram of the structure of the present invention.
FIG. 2a is a schematic view showing that the filamentous embolic agent is in a floating state in a blood vessel after being injected into the blood vessel, and cannot be separated due to entanglement with each other.
FIG. 2b is a schematic representation of thrombus formation along a filamentous embolus.
FIG. 2c is a schematic view of a progressive thrombus formation along a filamentous embolus, completely occluding a blood vessel.
In the attached figure, 1-linear embolic agent, 2-delivery pipe, 3-injection pipe, 21-output part, 22-containing part, 23-connecting part and 4-hand ear.
Detailed Description
The present invention will be described in detail below with reference to the accompanying drawings.
As shown in figure 1, the fibrous chronic embolism device for preventing ectopic embolism comprises a linear embolic agent 1, a delivery pipe 2 and an injection pipe 3, wherein the linear embolic agent 1 is arranged in the delivery pipe 2, and both ends of the delivery pipe 2 are provided with detachable sealing caps; when the injection tube is used, the rear end of the conveying tube 2 is opened and connected with an outlet of the injection tube 3, the conveying tube 2 comprises a connecting part 23, a containing part 22 and an output part 21, two ends of the containing part 22 are respectively connected with the output part 21 and the connecting part 23, the connecting part 23 is connected with the output end of the injection tube 3, and the rear end of the injection tube 3 is provided with a pressurizing device; the diameters of the storage part 22 and the connecting part 23 are larger than that of the output part 21, the diameters of the storage part 22 to the output part 21 are gradually reduced, and the outer side of the connecting part 23 is provided with a handheld ear 4; opening a sealing cap at the front end of the delivery pipe 2 before the linear embolic agent 1 is injected; the linear embolic agent 1 is stored in the delivery pipe 2, and is connected with a normal saline injector to accelerate the injection and flush into blood vessels when in use.
The pressurizing device is a medical pulse pump, and the output end of the medical pulse pump is connected with the inlet of the injection tube 3.
The linear embolic agent 1 is provided with a spiral defect along the length direction; the rear end of the linear plugging agent 1 is provided with a chuck.
The material of the linear embolic agent 1 adopts polyethylene, silk, nylon, polyglycolic acid or synthetic polyester.
The surface of the linear embolic agent 1 is provided with capillary fibers formed by polishing; the diameter of the linear embolic agent 1 is less than 1 mm.
The front end of the linear embolic agent 1 is divided into a plurality of strands, and the strands are coated with an anticoagulation coating or a coagulation promoting coating, so that the anticoagulation coating or the coagulation promoting coating can prevent blood from attaching and coagulating or promote the attached blood to rapidly coagulate in blood vessels.
The surface of the wire embolic agent is coated with an anticoagulant coating or a coagulation promoting coating.
The embolization agent is biologically inert and non-degradable, the embolization agent under the microcosmic is a long-thread structure, is a single-thread silk or multi-thread silk, and can be in a chain shape, a thread shape or a spiral shape, the embolization agent can be developed under X-ray, the thread-shaped embolization agent is placed in a long needle head, the storage part 22 is filled with push preservation solution, and the embolization agent is injected into blood vessels by a pressurized water flushing method when in use.
In an alternative embodiment, the linear embolic agent 1 is provided with a spiral defect along the length direction, specifically, along the length direction, the diameter of the linear embolic agent 1 is changed at uniform intervals, the diameters of two adjacent sections are different, the interval is in a spiral trend, when a part with a smaller diameter receives liquid impact force, the part is bent and deformed first, so that embolism is easy to form, and the embolism is not easy to wander.
The filamentous embolic agent is stored in the storage part 22, and when in use, the injection tube is filled with physiological saline to accelerate the injection to be flushed into the blood vessel.
As shown in FIG. 2a, the filamentous embolic agent is in a floating state in the blood vessel after being injected into the blood vessel, and cannot be separated due to mutual entanglement; as shown in FIG. 2b, a thrombus forms along the filamentous embolus, acting to partially occlude the vessel; as shown in FIG. 2c, thrombus formation along the filamentous embolus gradually increases, completely occluding the vessel.
The invention designs the embolic agent into a bundle of long filamentous structures, the filaments fill the blood vessel after being injected into the blood vessel, blood flow still passes through the blood vessel in a short period, and the blood flow is gradually and completely blocked along with the gradual formation of the adhesion of the filaments to the thrombus, thereby causing the effect of chronic embolism; in addition, because the filaments are mutually dragged, the whole embolic agent is a whole, and the occurrence of ectopic embolism can be prevented.

Claims (6)

1. The fibrous chronic embolism device for preventing ectopic embolism is characterized by comprising a linear embolism agent (1), a delivery pipe (2) and an injection pipe (3), wherein the linear embolism agent (1) is arranged in the delivery pipe (2), and two ends of the delivery pipe (2) are respectively provided with a detachable sealing cap; when the injection tube is used, the rear end of the conveying tube (2) is opened and is connected with an outlet of the injection tube (3), the conveying tube (2) comprises a connecting part (23), a containing part (22) and an output part (21), two ends of the containing part (22) are respectively connected with the output part (21) and the connecting part (23), the connecting part (23) is connected with an output end of the injection tube (3), and a pressurizing device is arranged at the rear end of the injection tube (3); the linear embolic agent (1) is spiral, chain-shaped, single-strand wire or multi-strand wire-shaped along the length direction; the surface of the linear embolic agent (1) is provided with capillary fibers formed by polishing; the front end of the linear embolic agent (1) is divided into a plurality of strands, and the strands are coated with an anticoagulation coating or a coagulation promoting coating; the pressurizing device is a medical pulse pump, and the output end of the medical pulse pump is connected with the inlet of the injection tube (3).
2. The fibrous chronic embolization device for preventing ectopic embolization according to claim 1, wherein the diameters of the storage part (22) and the connecting part (23) are larger than the diameter of the output part (21), the diameters of the storage part (22) to the output part (21) are gradually reduced, and the outer side of the connecting part (23) is provided with a holding lug (4).
3. The fibrous chronic embolization device for preventing ectopic embolization according to claim 1, wherein the material of the linear embolization agent (1) is polyethylene, silk, nylon, polyglycolic acid or synthetic polyester.
4. The fibrous chronic embolization device to prevent ectopic embolization according to claim 1, wherein the linear embolization agent (1) has a diameter of less than 1 mm.
5. The fibrous chronic embolization device for preventing ectopic embolization according to claim 1, wherein the rear end of the linear embolization agent (1) is provided with a chuck.
6. The fibrochronic embolization device for preventing ectopic embolization according to claim 1, wherein the storage section (22) is filled with a push preservative solution.
CN201911399516.7A 2019-12-30 2019-12-30 Fibrous chronic embolism device for preventing ectopic embolism Active CN111134756B (en)

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CN114366212B (en) * 2022-01-20 2024-03-12 苏州大学附属第一医院 Gelatin sponge strip conveying system for temporary arterial embolism

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