CN111134665A

CN111134665A - Wearable epilepsy monitoring facilities

Info

Publication number: CN111134665A
Application number: CN201911387103.7A
Authority: CN
Inventors: 曾玮; 王清辉; 王颖; 刘凤琳; 袁成志; 李梦清; 陈阳
Original assignee: Longyan University
Current assignee: Longyan University
Priority date: 2019-12-30
Filing date: 2019-12-30
Publication date: 2020-05-12
Anticipated expiration: 2039-12-30
Also published as: CN111134665B

Abstract

The invention discloses wearable epilepsy monitoring equipment which comprises an implantable electrode device, a fixing cover and a wearable device, wherein the implantable electrode device is used for being fixed on a skull, the fixing cover is arranged on the implantable electrode device and is connected with the implantable electrode device, a microprocessor, a power supply, a Bluetooth module and a wireless charging module are arranged in the fixing cover, the microprocessor is used for processing data measured by the implantable electrode device and sending the data to the wearable device through the Bluetooth module, and the wearable device is arranged on the wrist of a patient. Compared with the prior art, the invention has convenient installation and reduces the operation pain of patients; the device can be taken down quickly when needing to be replaced, and has little harm to the brain of a patient; the invention is convenient to control, can wake a patient or automatically stimulate the brain before the epileptic seizure, and achieves the purposes of controlling the epileptic seizure and reducing the times of the epileptic seizure.

Description

Wearable epilepsy monitoring facilities

Technical Field

The invention belongs to the field of medical instruments, and particularly relates to wearable epilepsy monitoring equipment.

Background

Epilepsy is a chronic neurological disease due to abnormal and excessive cerebral neuronal activity, with EEG signals being the most common and effective method for detecting epilepsy.

Epileptic patients often have poor response to antiepileptic drugs, and long-term administration of drugs can seriously affect the body of the patient, and if the drugs are not taken in time, the epileptic seizures are easy to occur. Surgical removal of the focal area of epilepsy is a more effective method of treating epilepsy, but it has difficulties when the area of epilepsy is large or the location is inconvenient for surgery.

Therefore, there is a need for a device that can timely remind the patient to avoid or reduce epileptic seizures by way of electrical stimulation, either manually or automatically.

Disclosure of Invention

In view of the above technical problems, the present invention provides a wearable epilepsy monitoring device, which is intended to detect the change of electroencephalogram signals before a seizure, and at the same time, automatically or manually control electrodes to stimulate, reduce the seizure and protect the brain.

In order to solve the technical problems, the technical scheme of the invention is as follows:

a wearable epilepsy monitoring device comprises an implanted electrode device 1, a fixed cover 2 and a wearable device 3, wherein the implanted electrode device 1 is used for being fixed on a skull at an epilepsy focus determined in advance, the fixed cover 2 is arranged on the implanted electrode device 1 and connected with the implanted electrode device 1, a microprocessor, a power supply, a Bluetooth module, a wireless communication device and a wireless charging module are arranged inside the fixed cover 2, the microprocessor is used for processing data measured by the implanted electrode device 1, then sending the data to the cloud end through the wireless communication device and receiving the result processed by the cloud end, the microprocessor judges whether to control an electrode to carry out electrical stimulation according to the result, meanwhile, the microprocessor sends the result to the wearable device 3 through the Bluetooth module, and the wearable device 3 reminds a patient whether to continuously carry out manual brain stimulation, the wearing device 3 is provided at the wrist of the patient.

Further, a first electrode 1.1 is arranged at the center of the implanted electrode device 1, an upper support frame 1.2 is arranged at the upper part of the first electrode 1.1, an upper clamping end 1.4 is arranged at the end part of the upper support frame 1.2, an upper circular shaft 1.3 is arranged in a cavity of the upper clamping end 1.4, a lower support frame 1.5 is arranged at the lower part of the first electrode 1.1, a lower circular shaft 1.6 is arranged at the end part of the lower support frame 1.5, an upper sliding chute 1.8 is arranged at the upper part of the movable rod 1.7, a lower sliding chute 1.9 is arranged at the lower part, the upper sliding chute 1.8 is matched with the upper circular shaft 1.3, the lower sliding chute 1.9 is matched with the lower circular shaft 1.6, the upper sliding chute 1.8 is provided with a first fork part 1.12 and a second fork part 1.13, a connecting end 1.14 is arranged at the upper end of the second fork part 1.13, a lower clamping end 1.10 is arranged at the side surface of the lower part of the movable rod 1.7, a second electrode 1.11 and a second electrode 1.11 are connected with a microprocessor through a second clamping end 1.11, the connecting end 1.14 is provided with threads which are matched with the threads on the fixing cover, and the upper clamping end 1.4 and the lower clamping end 1.10 are provided with anti-skid protrusions.

Further, the wearable device 3 is provided with a shell 3.1, a first display screen 3.2 and a second display screen 3.3 are arranged on the shell 3.1, a prompt lamp 3.4 is arranged around the display screen, a button 3.5 corresponding to each prompt lamp 3.4 is arranged on the outer side of each prompt lamp 3.4, a plurality of prompt lamps 3.4 are arranged and correspondingly represent a plurality of different time levels, the button 3.5 is pressed to represent that corresponding stimulation time is selected, a knob 3.6 is arranged on the side face of the shell 3.1, the knob 3.6 is used for adjusting the intensity and frequency of electric stimulation, the intensity and frequency are respectively displayed through the first display screen 3.2 and the second display screen 3.3, a loudspeaker 3.7 is arranged on the other side of the shell 3.1 opposite to the knob 3.6, and a vibration head 3.8 is arranged on the back face of the shell 3.1.

Further, the implanted electrode device 1 acquires the electroencephalogram signals at the epileptic focus and then sends the acquired electroencephalogram signals to the microprocessor inside the fixed cover 2, and the microprocessor performs the following processing:

firstly, denoising and reconstructing the three-order Daubechies wavelet function by utilizing four-layer wavelet transform;

secondly, performing complementary set empirical mode decomposition (CEEMD) on the de-noised and reconstructed electroencephalogram signals, decomposing the electroencephalogram signals into intrinsic mode components (IMFs), and extracting third and fourth IMF components containing most electroencephalogram signal energy to serve as main IMFs;

then, carrying out phase space reconstruction on the two main IMF components, calculating Euclidean distance ED after carrying out phase space reconstruction on the two main IMF components, and deriving features, wherein the feature signals prove that the EEG signal mode of the epileptic precursor phase of the epileptic patient is obviously different from the EEG signal modes of other states;

then, the derived characteristic signals are sent to the cloud end through a wireless communication device of the fixed cover 2 to serve as input signals of the RBF neural network, a group of dynamic estimators are constructed by the neural network, and the difference between the input signals and brain electrical signal modes in a database stored in the cloud end is calculated;

if the difference between the input signal and the preempt period signal in the database is minimum, the input signal is judged to be the preempt period signal; if the difference between the input signal and the epileptic seizure interval signal in the database is minimum, the input signal is judged as the epileptic seizure interval signal; if the difference between the input signal and the epileptic seizure phase signal in the database is minimum, the input signal is judged to be the epileptic seizure phase signal;

and for the signal which is judged to be in the preempt period of the epileptic seizure, the cloud sends the judgment result back to the microprocessor in the fixed cover 2 for brain stimulation.

Further, the other states are inter-seizure and seizure phases, and the brain electrical signal pattern includes pre-seizure signals, inter-seizure signals and intra-seizure signals.

Further, the wearing device 3 informs the epileptic through the modes of the prompting lamp 3.4 flickering, the loudspeaker 3.7 giving out the prompting sound and the vibrating head 3.8 vibrating.

Furthermore, a plurality of upper support frames 1.2, lower support frames 1.5 and movable rods 1.7 are uniformly arranged around the first electrode 1.1; preferably 4-12.

Further, the lower clamping end 1.10 is an elastic body, and when the implantable electrode device 1 is inserted into a hole formed in the skull, the lower clamping end 1.10 can be compressed to generate deformation, and can recover after being inserted, and is a flexible clamping when being clamped.

Compared with the prior art, the invention has the following beneficial effects: the invention has convenient installation and reduces the operation pain of patients; the device can be taken down quickly when needing to be replaced, and has little harm to the brain of a patient; the invention is convenient to control, can wake a patient or automatically stimulate the brain before the epileptic seizure, achieves the aims of controlling the epileptic seizure without seizures, reducing the times of the epileptic seizure and protecting the brain.

Drawings

FIG. 1 is a first schematic view of an implantable electrode device according to the present invention;

FIG. 2 is a second schematic structural view of an implantable electrode assembly of the present invention;

FIG. 3 is a third schematic view of an implantable electrode assembly of the present invention;

FIG. 4 is a schematic view of the movable rod structure of the present invention;

FIG. 5 is a schematic view of the support device of the present invention;

FIG. 6 is a first top view of an implantable electrode device in accordance with the present invention;

FIG. 7 is a second top view of the implantable electrode device of the present invention;

FIG. 8 is a schematic view of an implantable electrode assembly with a retaining cap according to the present invention;

FIG. 9 is a cross-sectional view of an implantable electrode assembly with a retaining cap in accordance with the present invention;

FIG. 10 is a schematic diagram of a movable rod rotation structure of the implantable electrode assembly of the present invention;

FIG. 11 is a cross-sectional view of a movable rod of an implantable electrode assembly of the present invention in rotation;

FIG. 12 is a schematic view of an implantable electrode assembly of the present invention clamped to the skull;

FIG. 13 is a front view of the wearable device of the present invention;

FIG. 14 is a schematic view of the right side of the inventive wearing device;

FIG. 15 is a schematic view of the left side of the wearing device of the present invention;

FIG. 16 is a rear side view of the wearable device of the present invention;

in the figure, an implanted electrode device 1, a first electrode 1.1, an upper support frame 1.2, an upper round shaft 1.3, an upper clamping end 1.4, a lower support frame 1.5, a lower round shaft 1.6, a movable rod 1.7, an upper chute 1.8, a lower chute 1.9, a lower clamping end 1.10, a second electrode 1.11, a first fork part 1.12, a second fork part 1.13, a connecting end 1.14, a connecting wire 1.15, a fixed cover 2, a wearing device 3, a housing 3.1, a first display screen 3.2, a second display screen 3.3, a prompting lamp 3.4, a button 3.5, a knob 3.6, a horn 3.7 and a vibration head 3.8 are arranged.

Detailed Description

The technical solutions in the embodiments of the present invention will be clearly and completely described below with reference to the drawings in the embodiments of the present invention, and it is obvious that the described embodiments are only a part of the embodiments of the present invention, and not all of the embodiments. All other embodiments, which can be derived by a person skilled in the art from the embodiments given herein without making any creative effort, shall fall within the protection scope of the present invention.

In the description of the present invention, it is to be understood that the terms "center", "length", "width", "thickness", "upper", "lower", "front", "rear", "left", "right", "vertical", "horizontal", "top", "bottom", "inner", "outer", "axial", "circumferential", and the like, indicate orientations or positional relationships based on those shown in the drawings, and are used merely for convenience of description and for simplicity of description, and do not indicate or imply that the device or element being referred to must have a particular orientation, be constructed and operated in a particular orientation, and thus, are not to be considered as limiting the present invention.

In the present invention, unless otherwise expressly specified or limited, the terms "disposed," "mounted," "connected," and "fixed" are to be construed broadly and may, for example, be fixedly connected or detachably connected; may be a mechanical connection; may be directly connected or indirectly connected through an intermediate. The specific meanings of the above terms in the present invention can be understood by those skilled in the art according to specific situations.

Furthermore, the terms "first", "second", etc. are used for descriptive purposes only and are not to be construed as indicating or implying relative importance or implicitly indicating the number of technical features indicated. Thus, a feature defined as "first" or "second" may explicitly or implicitly include one or more of that feature.

Epilepsy is a chronic neurological disease due to abnormal and excessive cerebral neuronal activity, with EEG signals being the most common and effective method for detecting epilepsy. Epileptic patients often have poor response to antiepileptic drugs, and long-term administration of drugs can seriously affect the body of the patient, and if the drugs are not taken in time, the epileptic seizures are easy to occur. Surgical removal of the focal area of epilepsy is a more effective method of treating epilepsy, but it has difficulties when the area of epilepsy is large or the location is inconvenient for surgery.

The invention provides wearable epilepsy monitoring equipment, which aims to detect the change of an electroencephalogram signal before an epileptic seizure, and simultaneously automatically or manually control an electrode to stimulate, reduce the epileptic seizure and protect the brain.

The invention discloses wearable epilepsy monitoring equipment, which comprises an implantable electrode device 1, a fixed cover 2 and a wearing device 3, wherein the implantable electrode device 1 is fixed on a skull, the setting position of the implantable electrode device 1 can be judged and determined by a doctor, then an implantable electrode is implanted on the skull near a focal region, and the implantable electrode device is arranged in a manner of punching on the skull.

The fixed cover 2 is disposed on the implantable electrode device 1 and connected to the implantable electrode device 1, and a microprocessor, a power supply, a bluetooth module, a wireless communication device and a wireless charging module are disposed inside the fixed cover 2, which are not shown in the drawings, but those skilled in the art can know the connection mode among the microprocessor, the power supply, the bluetooth module, the wireless communication device and the wireless charging module and the connection mode with external components through the description in the present application and the knowledge in the art. The microprocessor is used for processing data (electroencephalogram signals) measured by the implanted electrode device 1, then sending the data to the cloud end through the wireless communication device, receiving results processed by the cloud end, judging whether the electrodes need to be controlled to perform electrical stimulation according to the results by the microprocessor, sending the results to the wearable device 3 through the Bluetooth module by the microprocessor, reminding the patient whether the patient needs to continuously perform manual brain stimulation through the wearable device 3, and setting the wearable device 3 on the wrist of the patient.

The implanted electrode device 1 is arranged in the hole in a penetrating mode through punching on the skull, the punched hole is a through hole, only one hole needs to be punched when one implanted electrode device is installed, and a plurality of holes do not need to be punched around the electrode device like the prior art, the implanted electrode device has the advantages that the arrangement area of the electrode device is reduced, the number of the arranged electrode devices can be increased without punching on the periphery, the more accurate measurement can be realized, and the specific structure of the electrode device is shown in figures 1-5. A first electrode 1.1 is arranged at the center of the implanted electrode device 1, an upper support frame 1.2 is arranged at the upper part of the first electrode 1.1, an upper clamping end 1.4 is arranged at the end part of the upper support frame 1.2, an upper round shaft 1.3 is arranged in a cavity of the upper clamping end 1.4, a lower support frame 1.5 is arranged at the lower part of the first electrode 1.1, a lower round shaft 1.6 is arranged at the end part of the lower support frame 1.5, an upper sliding chute 1.8 is arranged at the upper part of the movable rod 1.7, a lower sliding chute 1.9 is arranged at the lower part of the movable rod 1.8, the upper sliding chute 1.8 is matched with the upper round shaft 1.3, the lower sliding chute 1.9 is matched with the lower round shaft 1.6, the upper sliding chute 1.8 is provided with a first fork part 1.12 and a second fork part 1.13, a connecting end 1.14 is arranged at the upper end of the second fork part 1.13, a lower clamping end 1.7 is provided with a lower clamping end 1.10, a second electrode 1.11 is fixed at the lower side of the lower clamping end 1.10, and the first electrode 1, set up the screw thread on the link 1.14, with the fixed screw-thread fit who covers, fixed lid 2 and the rotatory installation of link 1.14, the side extrusion link 1.14 of fixed lid 2, thereby make first fork portion 1.12 cross last round axle 1.3, second fork portion 1.13 supports with last round axle 1.3 and leans on, the length design of connecting wire 1.15 satisfies and can rotate at fixed lid 2, even connecting wire 1.15 revolutes for a bit and does not influence yet, be provided with the non-skid protrusion on last exposed core 1.4 and the lower exposed core 1.10. The upper clamping end 1.4 and the lower clamping end 1.10 are clamped on the upper surface and the lower surface of the skull respectively, and the detachable connection prevents secondary injury. According to the plan view of the device and the schematic view of the installation of the fixed cover 2 shown in fig. 6-12, the fixed cover 2 is installed by fixing the cover in a threaded connection mode, namely a rotation mode, in the rotation process of the fixed cover 2, not only can the clamping function be achieved, but also the connecting wire can be wound on the device to achieve the effect of shrinking the wire, only one fixed cover can achieve two effects, the device is more compact, and the installation is facilitated. Because the design of the fixed cover can not rotate for many turns or better setting is not more than one turn, the connecting wire can not rotate or wind too much and can not have any influence on the connecting wire. In fig. 12, the implanted electrode device 1 is flanked by the skull bone, and a schematic view of the connection to the skull bone is shown.

As shown in fig. 13-16, the wearable device 3 has a housing 3.1, a first display 3.2 and a second display 3.3 are disposed on the housing 3.1, a plurality of indicator lights 3.4 are disposed around the display, a button 3.5 corresponding to each indicator light 3.4 is disposed outside the indicator lights 3.4, the indicator lights 3.4 are disposed in plurality and correspondingly represent a plurality of different time levels, pressing the button 3.5 represents selecting a corresponding stimulation time, a knob 3.6 is disposed on a side surface of the housing 3.1, the knob 3.6 is used for adjusting intensity and frequency of electrical stimulation, the intensity and frequency are respectively displayed through the first display 3.2 and the second display 3.3, a speaker 3.7 is disposed on the other side of the housing 3.1 opposite to the knob 3.6, and a vibrating head 3.8 is disposed on a back surface of the housing 3.1. When the processing result of the cloud received by the microprocessor is that electrical stimulation is needed, the wearable device 3 informs the epileptic patient in a mode of flashing the prompting lamp 3.4 and giving out a prompting sound through the loudspeaker 3.7 and vibrating the vibrating head 3.8. Meanwhile, the patient can select the stimulation time through the button 3.5, the intensity of the electrical stimulation is adjusted through the knob 3.6, the first display screen 3.2 displays the current intensity level, the knob 3.6 is pulled out for a short distance to adjust the frequency of the electrical stimulation, and the second display screen 3 displays the current stimulation frequency.

The microprocessor of the implanted electrode device performs the following processing:

secondly, performing Complementary Ensemble Empirical Mode Decomposition (CEEMD) on the de-noised and reconstructed electroencephalogram signal, decomposing the electroencephalogram signal into intrinsic mode components (IMFs), and extracting third and fourth IMF components containing most electroencephalogram signal energy to serve as main IMFs;

then, performing phase space reconstruction on the two main IMF components, wherein the attribute associated with the brain electrical system dynamic state is reserved, and calculating the Euclidean distance ED after performing phase space reconstruction on the two main IMF components for deriving a characteristic signal, wherein the characteristic signal proves that the brain electrical signal pattern of the epileptic precursor stage of the epileptic patient has a significant difference with the brain electrical signal patterns of other states (inter-epileptic seizure and epileptic seizure stage);

then, the derived characteristic signals are sent to the cloud end through a wireless communication device of the fixed cover 2 to serve as input signals of an RBF neural network, a group of dynamic estimators are constructed by the neural network, and the difference between the input signals and brain electrical signal modes (including preeclampsia signals, interphase epileptic seizure signals and epileptic seizure signals) in a database stored in the cloud end is calculated;

A plurality of upper support frames 1.2, lower support frames 1.5 and movable rods 1.7 are uniformly arranged around the first electrode 1.1.

The lower clamping end 1.10 is an elastic body, when the implantable electrode device 1 is inserted into a hole formed in a skull, the lower clamping end 1.10 can be compressed to generate deformation and recover after insertion, and is flexibly clamped during clamping, so that the skull is not damaged, and the electrode device can be better clamped.

Claims

1. A wearable epilepsy monitoring apparatus, comprising an implantable electrode device (1), a stationary cover (2) and a wearable device (3), characterized in that:

the implanted electrode device (1) is used for being fixed on the skull at the epileptogenic focus area which is determined in advance, the fixed cover (2) is arranged on the implanted electrode device (1), is connected with the implanted electrode device (1), a microprocessor, a power supply, a Bluetooth module, a wireless communication device and a wireless charging module are arranged in the fixed cover (2), the microprocessor is used for processing the data measured by the implanted electrode device (1), then the data is sent to the cloud end through a wireless communication device, the result processed by the cloud end is received, the microprocessor judges whether the electrode needs to be controlled to carry out electric stimulation or not according to the result, microprocessor passes through bluetooth module simultaneously will the result is sent to wearing device (3), whether wearing device (3) remind the patient to need continuously carry out manual brain stimulation, wearing device (3) set up at patient's wrist.

2. The wearable epilepsy monitoring device of claim 1, wherein: a first electrode (1.1) is arranged at the center of the implanted electrode device (1), an upper support frame (1.2) is arranged at the upper part of the first electrode (1.1), an upper clamping end (1.4) is arranged at the end part of the upper support frame (1.2), an upper round shaft (1.3) is arranged in a cavity of the upper clamping end (1.4), a lower support frame (1.5) is arranged at the lower part of the first electrode (1.1), a lower round shaft (1.6) is arranged at the end part of the lower support frame (1.5), an upper chute (1.8) is arranged at the upper part of a movable rod (1.7), a lower chute (1.9) is arranged at the lower part of the movable rod, the upper chute (1.8) is matched with the upper round shaft (1.3), the lower chute (1.9) is matched with the lower round shaft (1.6), the upper chute (1.8) is provided with a first fork part (1.12) and a second fork part (1.13), a lower fork part (1.13) is arranged at the upper end of the second fork part (1.13), and a lower clamping end (10) is arranged at the side surface of, the fixed second electrode (1.11) of lower extreme of movable rod (1.7), first electrode (1.1) and second electrode (1.11) all are connected with microprocessor through connecting wire (1.15), set up the screw thread on link (1.14), with the screw-thread fit on the fixed lid, go up holder (1.4) and be provided with anti-skidding arch down on holder (1.10).

3. The wearable epilepsy monitoring device of claim 2, wherein: the wearable device (3) is provided with a shell (3.1), a first display screen (3.2) and a second display screen (3.3) are arranged on the shell (3.1), prompt lamps (3.4) are arranged around the display screens, buttons (3.5) corresponding to the prompt lamps (3.4) are arranged on the outer sides of the prompt lamps (3.4), the prompt lamps (3.4) are provided with a plurality of corresponding prompt lamps, the corresponding time levels are correspondingly represented, the corresponding stimulation time is selected by pressing the buttons (3.5), a knob (3.6) is arranged on the side face of the shell (3.1), the knob (3.6) is used for adjusting the intensity and frequency of electric stimulation, the intensity and the frequency are displayed through the first display screen (3.2) and the second display screen (3.3) respectively, a loudspeaker (3.7) is arranged on the other side of the shell (3.1) opposite to the knob (3.6), and a vibration head (3.8) is arranged on the back face of the shell (3.1).

4. The wearable epilepsy monitoring device of claim 3, wherein:

the implanted electrode device (1) acquires electroencephalogram signals at an epileptic focus and then sends the electroencephalogram signals to the microprocessor inside the fixed cover (2), and the microprocessor performs the following processing:

then, the derived characteristic signals are sent to the cloud end through a wireless communication device of the fixed cover (2) to serve as input signals of the RBF neural network, a group of dynamic estimators are constructed by the neural network, and the difference between the input signals and brain electrical signal modes in a database stored in the cloud end is calculated;

and for the signal which is judged to be in the preempt period of the epileptic seizure, the cloud sends the judgment result back to the microprocessor in the fixed cover (2) for brain stimulation.

5. The wearable epilepsy monitoring device of claim 4, wherein: the other states are inter-seizure and epileptic seizure, and the EEG signal patterns include pre-seizure signals, inter-seizure signals and epileptic seizure signals.

6. The wearable epilepsy monitoring device of claim 3, wherein: wearing device (3) through warning light (3.4) scintillation, loudspeaker (3.7) send the mode of warning sound and vibrations head (3.8) vibrations and inform epileptic.

7. The wearable epilepsy monitoring device of claim 2, wherein: a plurality of upper support frames (1.2), lower support frames (1.5) and movable rods (1.7) are uniformly arranged around the first electrode (1.1); preferably 4-12.

8. The wearable epilepsy monitoring device of claim 1, wherein: the lower clamping end (1.10) is an elastic body, when the implanted electrode device (1) is inserted into a hole formed in the skull, the lower clamping end (1.10) can be compressed to generate deformation, and can recover after being inserted, and is flexibly clamped during clamping.