CN111134635B - Method and device for detecting elasticity of blood vessel, electronic equipment and storage medium - Google Patents
Method and device for detecting elasticity of blood vessel, electronic equipment and storage medium Download PDFInfo
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- 230000005284 excitation Effects 0.000 claims abstract description 47
- 238000006073 displacement reaction Methods 0.000 claims abstract description 46
- 230000035487 diastolic blood pressure Effects 0.000 claims abstract description 45
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- 238000004590 computer program Methods 0.000 claims description 25
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- 238000005259 measurement Methods 0.000 abstract description 21
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- 238000002604 ultrasonography Methods 0.000 description 2
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Abstract
The application relates to a method, a device, an electronic device and a storage medium for detecting elasticity of blood vessels, wherein the method for detecting the elasticity of the blood vessels comprises the following steps: applying displacement excitation at the position of the blood vessel of the tester to excite the interior of the blood vessel to generate guided waves; transmitting a scanning signal to a blood vessel and receiving a feedback signal reflected by the blood vessel; determining the group velocity of the guided wave according to the feedback signal; acquiring diastolic pressure of a tester during testing; and determining the elasticity of the blood vessel according to the group velocity of the guided wave corresponding to the diastolic pressure. The method adopts the guided wave group velocity corresponding to the diastolic pressure to represent the elasticity of the blood vessel, and can decouple the influence of hypertension and angiosclerosis on the propagation velocity, thereby improving the measurement precision of the elasticity of the blood vessel and being applicable to clinical diagnosis of the angiosclerosis.
Description
Technical Field
The present application relates to the field of blood vessel detection technologies, and in particular, to a method and an apparatus for detecting elasticity of a blood vessel, an electronic device, and a storage medium.
Background
Cardiovascular and cerebrovascular diseases are the main chronic diseases causing human diseases to die, and are common diseases of middle-aged and elderly people over 50 years old. With age, angiosclerosis is an irreversible process, and therefore, early detection and monitoring of angiosclerosis has important value in the prevention and treatment of cardiovascular and cerebrovascular diseases.
Clinical studies have found that a sustained increase in blood pressure will lead to vascular sclerosis, which in turn will lead to an increase in blood pressure. Therefore, blood pressure and angiosclerosis are important indexes for detecting cardiovascular and cerebrovascular diseases. As far as the present is concerned, the measurement of blood pressure has a relatively sophisticated method and the associated measuring equipment is relatively inexpensive. But the measurement of the elastic properties of blood vessels lacks a mature, stable method.
The traditional method for measuring the elasticity of blood vessels is mainly a method for measuring the elasticity of blood vessels based on the velocity of pulse waves. In which, along with the cardiac cycle, there are periodic blood pressure fluctuations in the blood vessel, which are the pulse waves. Theoretical studies have shown that the propagation velocity of the pulse wave is related to the elastic properties of the vessel wall, and in general, the higher the elasticity of the vessel, the greater the velocity of the pulse wave.
However, since blood pressure also significantly affects the propagation velocity of the pulse wave, it is difficult to clarify the influence of blood pressure increase and vascular sclerosis on the propagation velocity using the conventional pulse wave method, resulting in poor measurement accuracy of the elasticity of the blood vessel.
Disclosure of Invention
In view of the above, it is necessary to provide a method, an apparatus, an electronic device, and a storage medium for detecting blood vessel elasticity, in order to solve the technical problem that the measurement accuracy of the conventional pulse wave method for blood vessel elasticity is not high.
A method of detecting elasticity of a blood vessel, the method comprising:
applying displacement excitation at the position of the blood vessel of the tester to excite the interior of the blood vessel to generate guided waves;
transmitting a scanning signal to the blood vessel and receiving a feedback signal reflected by the blood vessel;
determining a group velocity of the guided wave from the feedback signal;
acquiring diastolic pressure of the test subject during the period of test;
and determining the elasticity of the blood vessel according to the group velocity of the guided wave corresponding to the diastolic pressure.
In one embodiment, applying displacement excitation at a vascular site of a subject to excite generation of guided waves inside the blood vessel comprises:
acoustic radiation force is applied at the location of a blood vessel of a test subject to excite the interior of the blood vessel to produce guided waves.
In one embodiment, transmitting a scan signal to the blood vessel and receiving a feedback signal reflected by the blood vessel comprises:
and transmitting a scanning signal to the blood vessel at a preset frame frequency, and receiving a feedback signal reflected by the blood vessel.
In one embodiment, applying displacement excitation at a vascular site of a subject to excite generation of guided waves inside the blood vessel comprises:
acquiring a preset first time length, and applying displacement excitation at the position of a blood vessel of a tester in the first time length to excite the interior of the blood vessel to generate guided waves;
transmitting a scanning signal to the blood vessel and receiving a feedback signal reflected by the blood vessel, comprising:
and acquiring a preset second time length, transmitting a scanning signal to the blood vessel within the second time length, and receiving a feedback signal reflected by the blood vessel.
In one embodiment, acquiring a preset first time period, within which a displacement excitation is applied at a blood vessel position of a tester to excite the interior of the blood vessel to generate guided waves, includes:
acquiring a preset third time length, waiting according to the third time length, acquiring a preset second time length after the waiting is finished, transmitting a scanning signal to the blood vessel within the second time length, and receiving a feedback signal reflected by the blood vessel.
In one embodiment, acquiring a preset second time period, after transmitting a scanning signal to the blood vessel and receiving a feedback signal reflected by the blood vessel during the second time period, the method includes:
and acquiring a preset fourth time length, waiting according to the fourth time length, acquiring the preset first time length again after the waiting is finished, and applying displacement excitation at the position of the blood vessel of the tester in the first time length so as to excite the interior of the blood vessel to generate guided waves.
In one embodiment, the value of the first duration includes 600 μ s, the value of the second duration includes 4ms, the value of the third duration includes 400 μ s, and the value of the fourth duration includes 65 ms.
A device for measuring elasticity of a blood vessel, the device comprising:
the displacement excitation module is used for applying displacement excitation at the position of a blood vessel of a tester so as to excite the interior of the blood vessel to generate guided waves;
the scanning module is used for transmitting a scanning signal to the blood vessel and receiving a feedback signal reflected by the blood vessel;
the velocity determination module is used for determining the group velocity of the guided wave according to the feedback signal;
the diastolic pressure acquisition module is used for acquiring the diastolic pressure of the tester during the test period;
and the elasticity determining module is used for determining the elasticity of the blood vessel according to the group velocity of the guided wave corresponding to the diastolic pressure.
An electronic device comprising a memory and a processor, the memory storing a computer program, the processor implementing the following steps when executing the computer program:
applying displacement excitation at the position of the blood vessel of the tester to excite the interior of the blood vessel to generate guided waves;
transmitting a scanning signal to the blood vessel and receiving a feedback signal reflected by the blood vessel;
determining a group velocity of the guided wave from the feedback signal;
acquiring diastolic pressure of the test subject during the period of test;
and determining the elasticity of the blood vessel according to the group velocity of the guided wave corresponding to the diastolic pressure.
A computer-readable storage medium, on which a computer program is stored which, when executed by a processor, carries out the steps of:
applying displacement excitation at the position of the blood vessel of the tester to excite the interior of the blood vessel to generate guided waves;
transmitting a scanning signal to the blood vessel and receiving a feedback signal reflected by the blood vessel;
determining a group velocity of the guided wave from the feedback signal;
acquiring diastolic pressure of the test subject during the period of test;
and determining the elasticity of the blood vessel according to the group velocity of the guided wave corresponding to the diastolic pressure.
According to the method, the device, the electronic equipment and the storage medium for detecting the elasticity of the blood vessel, the elasticity of the blood vessel is represented by adopting the guided wave group velocity corresponding to the diastolic pressure, so that the influence of hypertension and angiosclerosis on the propagation velocity can be decoupled, the measurement precision of the elasticity of the blood vessel is improved, and the method, the device, the electronic equipment and the storage medium can be applied to clinical diagnosis of angiosclerosis.
Drawings
FIG. 1 is a schematic flow chart of a method for detecting elasticity of a blood vessel according to an embodiment;
FIG. 2 is a schematic flow chart of an embodiment for performing elastography using a particular imaging sequence;
FIG. 3 is a schematic illustration of an imaging sequence in one embodiment;
FIG. 4 is a B-ultrasound view of a carotid artery in one embodiment;
FIG. 5 is a graph showing the results of three independent experiments performed by the same tester in one embodiment;
FIG. 6 is a block diagram showing the structure of a blood vessel elasticity detecting apparatus according to an embodiment;
FIG. 7 is a diagram illustrating an internal structure of an electronic device in one embodiment.
Detailed Description
In order to make the objects, technical solutions and advantages of the present application more apparent, the present application is described in further detail below with reference to the accompanying drawings and embodiments. It should be understood that the specific embodiments described herein are merely illustrative of the present application and are not intended to limit the present application.
In one embodiment, as shown in fig. 1, there is provided a method for detecting elasticity of a blood vessel, comprising the steps of:
and S202, applying displacement excitation at the position of the blood vessel of the tester to excite the interior of the blood vessel to generate guided waves.
Wherein the displacement excitation may be determined based on a displacement waveform comprising a single sine wave pulse, a harmonic, a triangular wave, or a broadband wave.
Specifically, an elastography device is placed at the position of a blood vessel of a tester, and the elastic imaging device applies displacement excitation at the position of the blood vessel of the tester, such as acoustic radiation force or mechanical excitation, so as to push soft tissue in the blood vessel to deform, thereby exciting guided waves in the blood vessel.
Alternatively, the acoustic beam may be focused at a single point or moved to focus within the vessel wall when the acoustic radiation force is applied. Wherein, moving focus means focusing at different depths in the blood vessel successively.
S204, transmitting a scanning signal to the blood vessel and receiving a feedback signal reflected by the blood vessel.
Specifically, the elastography device is switched to a plane wave imaging mode after applying displacement excitation, transmits scanning signals to the position of a blood vessel at a preset frame frequency, and simultaneously receives feedback signals returned by the blood vessel so as to monitor the propagation process of guided waves. Wherein the feedback signal is indicative of the propagation of the guided wave within the blood vessel of the subject.
Alternatively, an ultrasonic transducer may be used to monitor the propagation process of the guided wave in the blood vessel by scanning the position of the blood vessel of the tester with ultrasonic signals at a frame frequency of 8000 frames per second or more, and receiving the returned ultrasonic echo signals. The central frequency of the shear wave in the soft tissue is generally not more than 800Hz, so that the propagation process of the guided wave in the blood vessel can be completely recorded by the frame frequency according to the sampling theorem, and further parameter values of the guided wave, such as group velocity, can be obtained. By setting a higher imaging frame frequency, the influence of the movement of a tester and the like on the detection result can be avoided, so that the detection result has better repeatability.
Alternatively, the blood vessel can also be scanned with a photoacoustic scanner.
And S206, determining the group velocity of the guided wave according to the feedback signal.
Specifically, the elastography device performs imaging on the feedback signal after obtaining the feedback signal, and obtains an image sequence, such as an ultrasound image sequence. By comparing the different images, the group velocity of the guided waves can be determined.
And S208, acquiring the diastolic pressure of the tester during the test period.
Specifically, a blood pressure measurement device is used to measure the blood pressure, including diastolic pressure, of a subject during the subject's test.
S210, determining the elasticity of the blood vessel according to the group velocity of the guided wave corresponding to the diastolic pressure.
Specifically, during the period of the subject, the group velocity of the guided wave corresponding to the diastolic pressure can be obtained according to the correspondence relationship between the blood pressure of the subject and the group velocity of the guided wave, for example, according to the time coincidence relationship, and the group velocity of the guided wave corresponding to the diastolic pressure can be used to characterize the elasticity of the blood vessel.
According to the detection method of the blood vessel elasticity, the blood vessel elasticity is represented by the guided wave group velocity corresponding to the diastolic pressure, and the influence of hypertension and angiosclerosis on the propagation velocity can be decoupled, so that the measurement accuracy of the blood vessel elasticity is improved, and the method can be applied to clinical diagnosis of angiosclerosis.
In one embodiment, referring to fig. 4, acoustic radiation force can be applied at the vascular site of the subject using an ARFI (single point excitation ultrasound elastography) method or an SSI (fast shear wave imaging) method to excite the inside of the blood vessel to generate guided waves.
In the present embodiment, since the pulse wave method uses a low-frequency pulse wave having a larger wavelength, the pulse wave method has a lower spatial resolution, and compared to the conventional pulse wave method, uses an acoustic radiation force to excite a guided wave in a blood vessel wall, where the guided wave has a higher frequency, thereby having a higher spatial resolution, and facilitating more accurate detection of the elastic properties of the blood vessel.
In order to achieve the detection of the elasticity of the blood vessel at different blood pressures throughout the cardiac cycle, in one embodiment, a specific imaging sequence is used to elastography the blood vessel, and thus the elasticity parameters of the blood vessel are obtained. On the basis of the above embodiment, S202 includes the steps of:
s2022, obtaining a preset first time length, and applying displacement excitation at the position of the blood vessel of the tester in the first time length to excite the interior of the blood vessel to generate guided waves.
Specifically, the first period is set as the application period of the displacement excitation. For example, the first time period is 500 μ s, the elastography device continuously applies displacement excitation to the blood vessel position of the tester according to the time period of 500 μ s so as to continuously generate guided waves in the blood vessel of the tester.
Optionally, the value of the first time length may be any one of 500 μ s to 700 μ s.
Further, in one embodiment, S2022 is followed by the steps of:
s2032, a preset third time length is obtained, waiting is carried out according to the third time length, after the waiting is finished, a preset second time length is obtained, a scanning signal is transmitted to the blood vessel within the second time length, and a feedback signal reflected by the blood vessel is received.
Specifically, after the completion of the displacement excitation is applied according to the first time length, the elastography device enters a waiting state for a third time length, and after the waiting is completed, a scanning signal is transmitted to the blood vessel, and meanwhile, a feedback signal reflected by the blood vessel is received.
Optionally, the value of the third time period may be any one of 300 μ s to 500 μ s.
Further, in one embodiment, S204 includes the steps of:
s2042, acquiring a preset second time duration, transmitting a scanning signal to the blood vessel in the second time duration, and receiving a feedback signal reflected by the blood vessel.
Specifically, the second period is set as the transmission period of the scanning signal. For example, if the second time duration is 4ms, the elastography device transmits a scanning signal to the position of the blood vessel of the testee according to the time duration of 4ms and receives a feedback signal reflected by the blood vessel.
Optionally, the value of the second duration may be any one of 2ms to 5 ms.
Further, in one embodiment, S2042 is followed by the steps of:
and S2052, acquiring a preset fourth time length, waiting according to the fourth time length, acquiring the preset first time length again after the waiting is finished, and applying displacement excitation to the position of the blood vessel of the tester within the first time length so as to excite the interior of the blood vessel to generate guided waves.
Specifically, after the scanning signal is transmitted according to the second time length, the elastic imaging device enters a waiting state for the fourth time length, and after the waiting is completed, the displacement excitation is applied to the position of the blood vessel of the tester again to continuously generate the guided wave in the blood vessel of the tester.
Optionally, the value of the fourth time length may be any one of 50ms to 80 ms.
By setting different working states with different time lengths, the elasticity imaging device is adaptive to the defects on the hardware performance on one hand, and on the other hand, the whole imaging process is smaller than one cardiac cycle, so that the effect that the blood pressure born by the similar blood vessel wall is not changed is achieved.
Referring to FIG. 3, in an alternative embodiment, the first time period is selected to be 600 μ s, the second time period is selected to be 4ms, the third time period is selected to be 400 μ s, and the fourth time period is selected to be 65 ms. That is, the elastography device takes 70ms as a period, and each period contains 4 subsequences, namely a displacement radiation excitation sequence, a first blank sequence, a plane wave imaging sequence and a second blank sequence. Wherein the displacement radiation excitation sequence is used to apply displacement excitation using an elastography device to generate guided waves; the plane wave imaging sequence is used for imaging the propagation process of guided waves in a plane wave imaging mode of the elastic imaging device to obtain a corresponding image sequence; the first blank sequence and the second blank sequence are limited by hardware performance defects of the elastography device during the working mode conversion, and the elastography device needs to be in a waiting state before the conversion because the mode conversion can not be carried out immediately.
It will be appreciated that in each cycle, the elastography device only needs to take 5ms during the imaging process, which is much less than one cardiac cycle (about 800ms), in addition to the longer time of the second blanking sequence. During this time (5ms), it is considered that the blood pressure applied to the blood vessel wall does not change, and the influence of the blood pressure on the elasticity of the blood vessel is avoided.
In one embodiment, the measurements may be made to cover different blood pressure values by multiple consecutive measurements. Specifically, it is assumed that 35 cycles are continuously measured each time the blood vessel elasticity is detected, and the measurement time is 2.45s for each cycle of 70 ms. In the normal heart rate range, the measurement duration spans about 3 cardiac cycles, i.e. it corresponds to about 12 consecutive measurements at equal time intervals in each cardiac cycle, so that the measurement results cover different blood pressure values.
In one embodiment, for the acquired guided wave propagation process, a time-of-flight algorithm is employed to determine group velocities of the guided waves. The guided wave propagation speed is mainly influenced by the elastic property of blood vessels, and the higher the hardening degree of the blood vessels is, the larger the elastic modulus is, and the larger the group velocity of the guided wave is.
In one embodiment, applicants have discovered through research that: the systolic pressure difference among different arterial blood vessels of a human body is obvious, but the diastolic pressure difference among different blood vessels is not large. For example, the diastolic pressures of the peripheral vessel and carotid artery are approximately equal. Therefore, by utilizing the characteristic, the diastolic pressure of the brachial artery is measured by adopting a cuff method such as a Korotkoff sound method or an oscillometric method before and after the elastography measurement of each tester, and the average value of the measurement results before and after the measurement is taken as the carotid artery diastolic pressure.
To further prove the feasibility of the above-described protocol, the applicant carried out a number of experiments and presented the results of the experiments as follows: referring to fig. 5, fig. 5 shows the results of three independent experiments performed on the same subject, wherein it can be seen that the velocity of the guided wave group in the blood vessel exhibits a variation synchronized with the cardiac cycle. The maximum value of the group velocity of the guided waves corresponds to the systolic pressure and the minimum value of the group velocity corresponds to the diastolic pressure. Comparing three experiments can find that: the axial guided wave group velocity corresponding to the diastolic pressure has good repeatability.
In the embodiment, the relation between the blood pressure and the vascular sclerosis can be cleared conveniently by combining the diastolic pressure and the corresponding guided wave group velocity of the diastolic pressure, so that the method can be used for clinically diagnosing the arteriosclerosis.
It should be understood that although the various steps in the flow charts of fig. 2-3 are shown in order as indicated by the arrows, the steps are not necessarily performed in order as indicated by the arrows. The steps are not performed in the exact order shown and described, and may be performed in other orders, unless explicitly stated otherwise. Moreover, at least some of the steps in fig. 2-3 may include multiple steps or multiple stages, which are not necessarily performed at the same time, but may be performed at different times, which are not necessarily performed in sequence, but may be performed in turn or alternately with other steps or at least some of the other steps.
In one embodiment, as shown in fig. 6, there is provided a vascular elasticity measurement device 30 comprising: a displacement excitation module 302, a scanning module 304, a velocity determination module 306, a diastolic blood pressure acquisition module 308, and an elasticity determination module 310, wherein:
and a displacement excitation module 302 for applying displacement excitation at the position of the blood vessel of the tester to excite the interior of the blood vessel to generate guided waves.
A scanning module 304, configured to transmit a scanning signal to the blood vessel and receive a feedback signal reflected by the blood vessel.
A velocity determination module 306 configured to determine a group velocity of the guided wave according to the feedback signal.
A diastolic pressure obtaining module 308 for obtaining the diastolic pressure of the subject during the period of measurement.
And an elasticity determining module 310, configured to determine elasticity of the blood vessel according to the group velocity of the guided wave corresponding to the diastolic pressure.
The detection device for the elasticity of the blood vessel adopts the guided wave group velocity corresponding to the diastolic pressure to represent the elasticity of the blood vessel, and can decouple the influence of hypertension and angiosclerosis on the propagation velocity, thereby improving the measurement precision of the elasticity of the blood vessel and being applied to clinical diagnosis of the angiosclerosis.
In one embodiment, the displacement excitation module 302 is specifically configured to apply acoustic radiation force at a location of a blood vessel of a subject to excite generation of guided waves inside the blood vessel.
In one embodiment, the scanning module 304 is specifically configured to transmit a scanning signal to the blood vessel at a preset frame rate and receive a feedback signal reflected by the blood vessel.
In one embodiment, the displacement excitation module 302 is specifically configured to obtain a preset first time period, and within the first time period, apply displacement excitation at a blood vessel position of a tester to excite the interior of the blood vessel to generate guided waves; the scanning module is specifically configured to obtain a preset second time duration, transmit a scanning signal to the blood vessel within the second time duration, and receive a feedback signal reflected by the blood vessel.
In one embodiment, the apparatus for measuring elasticity of blood vessel further comprises: the system comprises a first waiting module (not shown) for acquiring a preset third time length, waiting according to the third time length, acquiring a preset second time length after waiting is finished, transmitting a scanning signal to the blood vessel within the second time length, and receiving a feedback signal reflected by the blood vessel.
In one embodiment, the apparatus for measuring elasticity of blood vessel further comprises: and a second waiting module (not shown) for acquiring a preset fourth time duration, waiting according to the fourth time duration, acquiring the preset first time duration again after the waiting is finished, and applying displacement excitation to the position of the blood vessel of the tester within the first time duration to excite the interior of the blood vessel to generate guided waves.
In one embodiment, the value of the first duration includes 600 μ s, the value of the second duration includes 4ms, the value of the third duration includes 400 μ s, and the value of the fourth duration includes 65 ms.
For the specific definition of the measuring device of the blood vessel elasticity, reference may be made to the above definition of the measuring method of the blood vessel elasticity, which is not described herein again. The modules in the blood vessel elasticity measuring device can be wholly or partially realized by software, hardware and a combination thereof. The modules can be embedded in a hardware form or independent from a processor in the computer device, and can also be stored in a memory in the computer device in a software form, so that the processor can call and execute operations corresponding to the modules.
In one embodiment, an electronic device is provided, which may be a terminal, and the internal structure thereof may be as shown in fig. 7. The electronic device comprises a processor, a memory, a communication interface, a display screen and an input device which are connected through a system bus. Wherein the processor of the electronic device is configured to provide computing and control capabilities. The memory of the electronic equipment comprises a nonvolatile storage medium and an internal memory. The non-volatile storage medium stores an operating system and a computer program. The internal memory provides an environment for the operation of an operating system and computer programs in the non-volatile storage medium. The communication interface of the electronic device is used for carrying out wired or wireless communication with an external terminal, and the wireless communication can be realized through WIFI, an operator network, NFC (near field communication) or other technologies. The computer program is executed by a processor to implement a method of detecting elasticity of a blood vessel. The display screen of the electronic equipment can be a liquid crystal display screen or an electronic ink display screen, and the input device of the electronic equipment can be a touch layer covered on the display screen, a key, a track ball or a touch pad arranged on the shell of the electronic equipment, an external keyboard, a touch pad or a mouse and the like.
Those skilled in the art will appreciate that the configuration shown in fig. 7 is a block diagram of only a portion of the configuration associated with the present application, and does not constitute a limitation on the electronic device to which the present application is applied, and a particular electronic device may include more or less components than those shown in the drawings, or may combine certain components, or have a different arrangement of components.
In one embodiment, an electronic device is provided, comprising a memory and a processor, the memory having a computer program stored therein, the processor implementing the following steps when executing the computer program:
applying displacement excitation at the position of the blood vessel of the tester to excite the interior of the blood vessel to generate guided waves;
transmitting a scanning signal to the blood vessel and receiving a feedback signal reflected by the blood vessel;
determining a group velocity of the guided wave from the feedback signal;
acquiring diastolic pressure of the test subject during the period of test;
and determining the elasticity of the blood vessel according to the group velocity of the guided wave corresponding to the diastolic pressure.
The electronic equipment adopts the guided wave group velocity corresponding to the diastolic pressure to represent the elasticity of the blood vessel, and can decouple the influence of hypertension and angiosclerosis on the propagation velocity, thereby improving the measurement precision of the elasticity of the blood vessel and being applicable to clinical diagnosis of angiosclerosis.
In one embodiment, the processor, when executing the computer program, further performs the steps of: acoustic radiation force is applied at the location of a blood vessel of a test subject to excite the interior of the blood vessel to produce guided waves.
In one embodiment, the processor, when executing the computer program, further performs the steps of: and transmitting a scanning signal to the blood vessel at a preset frame frequency, and receiving a feedback signal reflected by the blood vessel.
In one embodiment, the processor, when executing the computer program, further performs the steps of: acquiring a preset first time length, and applying displacement excitation at the position of a blood vessel of a tester in the first time length to excite the interior of the blood vessel to generate guided waves; and acquiring a preset second time length, transmitting a scanning signal to the blood vessel within the second time length, and receiving a feedback signal reflected by the blood vessel.
In one embodiment, the processor, when executing the computer program, further performs the steps of: acquiring a preset third time length, waiting according to the third time length, acquiring a preset second time length after the waiting is finished, transmitting a scanning signal to the blood vessel within the second time length, and receiving a feedback signal reflected by the blood vessel.
In one embodiment, the processor, when executing the computer program, further performs the steps of: and acquiring a preset fourth time length, waiting according to the fourth time length, acquiring the preset first time length again after the waiting is finished, and applying displacement excitation at the position of the blood vessel of the tester in the first time length so as to excite the interior of the blood vessel to generate guided waves.
In one embodiment, the processor, when executing the computer program, further performs the steps of: the value of the first time length comprises 600 mu s, the value of the second time length comprises 4ms, the value of the third time length comprises 400 mu s, and the value of the fourth time length comprises 65 ms.
In one embodiment, a computer-readable storage medium is provided, having a computer program stored thereon, which when executed by a processor, performs the steps of:
applying displacement excitation at the position of the blood vessel of the tester to excite the interior of the blood vessel to generate guided waves;
transmitting a scanning signal to the blood vessel and receiving a feedback signal reflected by the blood vessel;
determining a group velocity of the guided wave from the feedback signal;
acquiring diastolic pressure of the test subject during the period of test;
and determining the elasticity of the blood vessel according to the group velocity of the guided wave corresponding to the diastolic pressure.
The computer-readable storage medium adopts the guided wave group velocity corresponding to the diastolic pressure to represent the elasticity of the blood vessel, so that the influence of hypertension and angiosclerosis on the propagation velocity can be decoupled, the measurement precision of the elasticity of the blood vessel is improved, and the computer-readable storage medium can be applied to clinical diagnosis of angiosclerosis.
In one embodiment, the computer program when executed by the processor further performs the steps of: acoustic radiation force is applied at the location of a blood vessel of a test subject to excite the interior of the blood vessel to produce guided waves.
In one embodiment, the computer program when executed by the processor further performs the steps of: and transmitting a scanning signal to the blood vessel at a preset frame frequency, and receiving a feedback signal reflected by the blood vessel.
In one embodiment, the computer program when executed by the processor further performs the steps of: acquiring a preset first time length, and applying displacement excitation at the position of a blood vessel of a tester in the first time length to excite the interior of the blood vessel to generate guided waves; and acquiring a preset second time length, transmitting a scanning signal to the blood vessel within the second time length, and receiving a feedback signal reflected by the blood vessel.
In one embodiment, the computer program when executed by the processor further performs the steps of: acquiring a preset third time length, waiting according to the third time length, acquiring a preset second time length after the waiting is finished, transmitting a scanning signal to the blood vessel within the second time length, and receiving a feedback signal reflected by the blood vessel.
In one embodiment, the computer program when executed by the processor further performs the steps of: and acquiring a preset fourth time length, waiting according to the fourth time length, acquiring the preset first time length again after the waiting is finished, and applying displacement excitation at the position of the blood vessel of the tester in the first time length so as to excite the interior of the blood vessel to generate guided waves.
In one embodiment, the computer program when executed by the processor further performs the steps of: the value of the first time length comprises 600 mu s, the value of the second time length comprises 4ms, the value of the third time length comprises 400 mu s, and the value of the fourth time length comprises 65 ms.
It will be understood by those skilled in the art that all or part of the processes of the methods of the embodiments described above can be implemented by hardware instructions of a computer program, which can be stored in a non-volatile computer-readable storage medium, and when executed, can include the processes of the embodiments of the methods described above. Any reference to memory, storage, database or other medium used in the embodiments provided herein can include at least one of non-volatile and volatile memory. Non-volatile Memory may include Read-Only Memory (ROM), magnetic tape, floppy disk, flash Memory, optical storage, or the like. Volatile Memory can include Random Access Memory (RAM) or external cache Memory. By way of illustration and not limitation, RAM can take many forms, such as Static Random Access Memory (SRAM) or Dynamic Random Access Memory (DRAM), among others.
The technical features of the above embodiments can be arbitrarily combined, and for the sake of brevity, all possible combinations of the technical features in the above embodiments are not described, but should be considered as the scope of the present specification as long as there is no contradiction between the combinations of the technical features.
The above-mentioned embodiments only express several embodiments of the present application, and the description thereof is more specific and detailed, but not construed as limiting the scope of the invention. It should be noted that, for a person skilled in the art, several variations and modifications can be made without departing from the concept of the present application, which falls within the scope of protection of the present application. Therefore, the protection scope of the present patent shall be subject to the appended claims.
Claims (10)
1. A method for detecting elasticity of a blood vessel, the method comprising:
applying displacement excitation at the position of the blood vessel of the tester to excite the interior of the blood vessel to generate guided waves;
transmitting a scanning signal to the blood vessel and receiving a feedback signal reflected by the blood vessel;
determining a group velocity of the guided wave from the feedback signal;
acquiring diastolic pressure of the test subject during the period of test;
and determining the minimum value in the group velocity of the guided waves as the group velocity of the guided waves corresponding to the diastolic pressure, and determining the elasticity of the blood vessel according to the group velocity of the guided waves corresponding to the diastolic pressure.
2. The method for detecting elasticity of blood vessels according to claim 1, wherein applying a displacement excitation at a position of a blood vessel of a subject to excite generation of guided waves inside the blood vessel comprises:
acoustic radiation force is applied at the location of a blood vessel of a test subject to excite the interior of the blood vessel to produce guided waves.
3. The method for detecting elasticity of blood vessels according to claim 1, wherein transmitting a scanning signal to the blood vessels and receiving a feedback signal reflected by the blood vessels comprises:
and transmitting a scanning signal to the blood vessel at a preset frame frequency, and receiving a feedback signal reflected by the blood vessel.
4. The method for detecting elasticity of blood vessels according to claim 1, wherein applying a displacement excitation at a position of a blood vessel of a subject to excite generation of guided waves inside the blood vessel comprises:
acquiring a preset first time length, and applying displacement excitation at the position of a blood vessel of a tester in the first time length to excite the interior of the blood vessel to generate guided waves;
transmitting a scanning signal to the blood vessel and receiving a feedback signal reflected by the blood vessel, comprising:
and acquiring a preset second time length, transmitting a scanning signal to the blood vessel within the second time length, and receiving a feedback signal reflected by the blood vessel.
5. The method for detecting the elasticity of the blood vessel according to claim 4, wherein a preset first time period is obtained, and after a displacement excitation is applied to the position of the blood vessel of the tester within the first time period to excite the interior of the blood vessel to generate the guided wave, the method comprises:
acquiring a preset third time length, waiting according to the third time length, acquiring a preset second time length after the waiting is finished, transmitting a scanning signal to the blood vessel within the second time length, and receiving a feedback signal reflected by the blood vessel.
6. The method for detecting the elasticity of the blood vessel according to claim 5, wherein after acquiring a preset second time period, transmitting a scanning signal to the blood vessel and receiving a feedback signal reflected by the blood vessel during the second time period, the method comprises:
and acquiring a preset fourth time length, waiting according to the fourth time length, acquiring the preset first time length again after the waiting is finished, and applying displacement excitation at the position of the blood vessel of the tester in the first time length so as to excite the interior of the blood vessel to generate guided waves.
7. The method according to claim 6, wherein the value of the first time period comprises 600 μ s, the value of the second time period comprises 4ms, the value of the third time period comprises 400 μ s, and the value of the fourth time period comprises 65 ms.
8. A device for measuring elasticity of a blood vessel, the device comprising:
the displacement excitation module is used for applying displacement excitation at the position of a blood vessel of a tester so as to excite the interior of the blood vessel to generate guided waves;
the scanning module is used for transmitting a scanning signal to the blood vessel and receiving a feedback signal reflected by the blood vessel;
the velocity determination module is used for determining the group velocity of the guided wave according to the feedback signal;
the diastolic pressure acquisition module is used for acquiring the diastolic pressure of the tester during the test period;
and the elasticity determining module is used for determining the minimum value in the group velocity of the guided waves as the group velocity of the guided waves corresponding to the diastolic pressure, and determining the elasticity of the blood vessel according to the group velocity of the guided waves corresponding to the diastolic pressure.
9. An electronic device comprising a memory and a processor, the memory storing a computer program, wherein the processor implements the steps of the method of any one of claims 1 to 7 when executing the computer program.
10. A computer-readable storage medium, on which a computer program is stored, which, when being executed by a processor, carries out the steps of the method of any one of claims 1 to 7.
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