CN111128367A - Modeling and simulating method and system for eyes - Google Patents
Modeling and simulating method and system for eyes Download PDFInfo
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- CN111128367A CN111128367A CN202010032479.2A CN202010032479A CN111128367A CN 111128367 A CN111128367 A CN 111128367A CN 202010032479 A CN202010032479 A CN 202010032479A CN 111128367 A CN111128367 A CN 111128367A
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- G16H—HEALTHCARE INFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR THE HANDLING OR PROCESSING OF MEDICAL OR HEALTHCARE DATA
- G16H50/00—ICT specially adapted for medical diagnosis, medical simulation or medical data mining; ICT specially adapted for detecting, monitoring or modelling epidemics or pandemics
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- G06T—IMAGE DATA PROCESSING OR GENERATION, IN GENERAL
- G06T17/00—Three dimensional [3D] modelling, e.g. data description of 3D objects
Abstract
The application provides a modeling and simulation method and system for eyes. The modeling and simulation method of the eye comprises the following steps: acquiring a medical image of a human eye; establishing a three-dimensional model of the eye according to the medical image of the human eye, wherein the three-dimensional model comprises three-dimensional models of an eyeball, an eyelid and surrounding soft tissues of the eyeball and the eyelid; and carrying out material and parameter setting, interactive setting, loading step and boundary condition setting on the eyeballs, the eyelids and the surrounding soft tissues thereof so as to establish a finite element model according to the three-dimensional model and simulate the human eye action through the finite element model. The modeling and simulation method for the eyes can realize the rapid and effective modeling of the eye structure of the human body and the calculation of the mechanical behavior of the eye structure under the eyeball rotation, thereby providing a reliable reference basis for medical analysis.
Description
Technical Field
The application relates to the technical field of medical imaging, in particular to a modeling and simulation method and system for eyes.
Background
The eyes are the most important organs in human sense, about 80% of information acquired by the brain from the outside is acquired through the eyes, and therefore, the health condition of the eyes directly influences the life quality of people. Eye lesions caused by various reasons further cause visual impairment and even loss, and cause great troubles to the work and life of people. Other common ophthalmic diseases, such as presbyopia, strabismus, amblyopia, myopia, glaucoma, and cataracts, have plagued eye clinicians and patients.
Although some of the eye models provide an eye model, and the eye disease of the patient is diagnosed according to the eye model, the eye model is not determined for different patients, and therefore, the individual difference cannot be considered from the perspective of the actual patient, thereby affecting the accuracy and reliability of the diagnosis of the disease.
Disclosure of Invention
The present application is directed to solving at least one of the above problems.
To this end, an object of the present application is to propose a method of modeling and simulation of an eye. The method can realize the rapid and effective modeling of the eye structure of the human body and the calculation of the mechanical behavior of the eye structure under the eyeball rotation, thereby providing a reliable reference basis for medical analysis.
A second object of the present application is to propose a modeling and simulation system for the eye.
In order to achieve the above object, a first aspect of the present application discloses an eye modeling and simulation method, including: acquiring a medical image of a human eye; establishing a three-dimensional model of the eye according to the medical image of the human eye, wherein the three-dimensional model comprises three-dimensional models of an eyeball, an eyelid and surrounding soft tissues of the eyeball and the eyelid; and carrying out material and parameter setting, interactive setting, loading step and boundary condition setting on the eyeballs, the eyelids and the surrounding soft tissues thereof so as to establish a finite element model according to the three-dimensional model and simulate the human eye action through the finite element model.
According to the modeling and simulation method of the eyes, the rapid and effective modeling of the eye structure of the human body and the calculation of the mechanical behavior of the eye structure under the eyeball rotation can be realized, so that a reliable reference basis is provided for medical analysis.
In some examples, the medical image of the human eye comprises a computed tomography medical image of the human eye or a magnetic resonance imaging medical image of the human eye.
In some examples, before the establishing the finite element model, further comprising: and optimizing the three-dimensional model.
In some examples, the interactive setup of the eyeball, eyelid and surrounding soft tissue comprises: a contact arrangement between the eyeball and the tissue structure; a coupling arrangement of the eyelid and its surrounding tissue; rigid body constraint is carried out on the eyeball; the setting of the load steps and the boundary conditions thereof comprises the following steps: selecting a coupling reference point of an eyelid and a surrounding tissue model; and selecting a rigid body constraint reference point of the eyeball.
A second aspect of the present application discloses a modeling and simulation system for an eye, comprising: the acquisition module is used for acquiring a medical image of the human eyes; the three-dimensional model establishing module is used for establishing a three-dimensional model of the eye according to the medical image of the human eye, wherein the three-dimensional model comprises three-dimensional models of an eyeball, an eyelid and surrounding soft tissues; and the finite element model establishing and simulating module is used for carrying out material and parameter setting, interactive setting, loading step and boundary condition setting on the eyeballs, the eyelids and the surrounding soft tissues thereof so as to establish a finite element model according to the three-dimensional model and simulate the eye action of the human body through the finite element model.
According to the modeling and simulation system for the eyes, the rapid and effective modeling of the eye structure of the human body and the calculation of the mechanical behavior of the eye structure under the rotation of the eyeballs can be realized, so that a reliable reference basis is provided for medical analysis.
In some examples, the medical image of the human eye comprises a computed tomography medical image of the human eye or a magnetic resonance imaging medical image of the human eye.
In some examples, further comprising: and the optimization module is used for optimizing the three-dimensional model.
In some examples, the interactive setup of the eyeball, eyelid and surrounding soft tissue by the finite element model building and simulation module comprises: a contact arrangement between the eyeball and the tissue structure; a coupling arrangement of the eyelid and its surrounding tissue; rigid body constraint is carried out on the eyeball; the finite element model building and simulating module sets the loading step and the boundary condition thereof, and comprises the following steps: selecting a coupling reference point of an eyelid and a surrounding tissue model; and selecting a rigid body constraint reference point of the eyeball.
Additional aspects and advantages of the present application will be set forth in part in the description which follows and, in part, will be obvious from the description, or may be learned by practice of the present application.
Drawings
The foregoing and/or additional aspects and advantages of the present application will become apparent and readily appreciated from the following description of the embodiments, taken in conjunction with the accompanying drawings of which:
FIG. 1 is a flow chart of a method of modeling and simulating an eye according to one embodiment of the present application;
FIG. 2 is a schematic diagram of a display interface after Mimcs imports human eye NMRI image data;
FIG. 3 is a schematic diagram of a preliminary three-dimensional model of an eyelid of an eye;
FIG. 4 is a schematic diagram of a generic CAD model of an eye eyelid;
FIG. 5 is a schematic diagram of an implementation of a method for modeling and simulating an eye according to an embodiment of the present application;
FIG. 6 is a diagram illustrating a result of eyeball rotation simulation calculation;
fig. 7 is a block diagram of a system for modeling and simulating an eye according to an embodiment of the present application.
Detailed Description
Reference will now be made in detail to the embodiments of the present application, examples of which are illustrated in the accompanying drawings, wherein like or similar reference numerals refer to the same or similar elements or elements having the same or similar function throughout. The embodiments described below with reference to the drawings are exemplary and intended to be used for explaining the present application and should not be construed as limiting the present application.
The following describes a modeling and simulation method and system for eyes according to an embodiment of the application with reference to the drawings.
FIG. 1 is a flow chart of a method of modeling and simulating an eye according to one embodiment of the present application. As shown in fig. 1, a modeling and simulation method of an eye according to an embodiment of the present application includes:
s101: a medical image of a human eye is acquired.
The medical image of the human eye comprises a medical image of the human eye of computed tomography or a medical image of the human eye of magnetic resonance imaging. Namely: the human eye may be scanned using conventional medical imaging techniques, such as Computed Tomography (CT), magnetic resonance imaging (NMRI), to obtain a medical image of the human eye.
S102: and establishing a three-dimensional model of the eye according to the medical image of the human eye, wherein the three-dimensional model comprises three-dimensional models of an eyeball, an eyelid and surrounding soft tissues.
Specifically, taking medical software, namely, Mimcs as an example, eye NMRI scanning data (i.e., medical images of human eyes) with a file format of DICOM is imported into Mimcs, and then three-dimensional model reconstruction of different tissue structures, namely, three-dimensional models of human eyes, is realized generally through the steps of creation of Masks → part generation → STLs generation, and the like. As shown in fig. 2, the display interface is displayed after the Mimcs is introduced into the medical image of the human eye, and the overall three-dimensional configuration of the eye can be viewed through the volume rendering command, as shown in the lower right corner of fig. 2.
The Mask establishment of different tissue structures is realized by an image segmentation technology of software, the software is preset with gray level threshold sets of different tissues (bones, soft tissues, muscles, skins and the like) for use, and the Mask establishment of a specific tissue structure can be realized by adopting the self-contained gray level threshold set of the software. Of course, if the automatic extraction organization is not accurate enough, the Mask can be created by self-defining the gray threshold. After masks of different eye tissue structures are established, the generation of Part and STL models is automatically realized through software.
As shown in fig. 3, the three-dimensional model of the eyeball, eyelid and surrounding soft tissue thereof preliminarily generated by the basic operation described above is shown, it can be understood that there are many unsmooth three-dimensional models and poor grid uniformity, and therefore, in a specific example, the three-dimensional model may be further subjected to smoothing, grid repartitioning and other processes by 3-Matic software, and finally a good general CAD model of the eyeball is obtained, as shown in fig. 4.
Of course, the three-dimensional model may be further optimized, for example: the obtained general eyeball CAD model is imported into computer aided design software to perform local optimization, grid reconstruction or optimization, file format conversion and other processing of a geometric model, in a specific embodiment of the application, a three-dimensional eyeball model in a dxf format is exported by using Mimcs and 3-Matic software, and then the three-dimensional eyeball model is imported into AutoCAD to modify the file format, and finally an iges format file is generated.
S103: and carrying out material and parameter setting, interactive setting, loading step and boundary condition setting on the eyeballs, the eyelids and the surrounding soft tissues thereof so as to establish a finite element model according to the three-dimensional model and simulate the human eye action through the finite element model.
Wherein, to the mutual setting of eyeball, eyelid and surrounding soft tissue, include: a contact arrangement between the eyeball and the tissue structure; a coupling arrangement of the eyelid and its surrounding tissue; rigid body constraint is carried out on the eyeball; the setting of the load steps and the boundary conditions thereof comprises the following steps: selecting a coupling reference point of an eyelid and a surrounding tissue model; and selecting a rigid body constraint reference point of the eyeball.
Specifically, the three-dimensional model is imported with general finite element software (such as ANSYS and ABAQUS), effective contact setting is carried out on the eyeball, the eyelid and the surrounding soft tissue structure, and the rest settings are set by a conventional method (namely, establishing a part → material setting → model assembling → setting a load step → interactive setting → applying load and boundary conditions → carrying out grid unit division → submitting work calculation) to complete simulation calculation of the whole model. In a specific example, a three-dimensional model is imported into ABAQUS, building up the components of the model of the eyeball and its surrounding tissue structure, as shown in the upper right corner of FIG. 5. The main settings are shown in table 1, the work is submitted for calculation, and the simulation calculation results are shown in fig. 6.
TABLE 1
According to the modeling and simulation method of the eye part, the rapid and effective modeling of the eye part structure of the human body and the calculation of the mechanical behavior of the eye part structure under the eyeball rotation can be realized, and therefore a reliable reference basis is provided for medical analysis.
FIG. 7 is a block diagram of a modeling and simulation system for an eye according to one embodiment of the present application. As shown in fig. 7, an eye modeling and simulation system 700 according to one embodiment of the present application includes: an acquisition module 710, a three-dimensional model building module 720 and a finite element model building and simulation module 730.
The obtaining module 710 is configured to obtain a medical image of an eye of a human body; the three-dimensional model establishing module 720 is used for establishing a three-dimensional model of the eye according to the medical image of the human eye, wherein the three-dimensional model comprises three-dimensional models of an eyeball, an eyelid and surrounding soft tissues; the finite element model establishing and simulating module 730 is used for performing material and parameter setting, interactive setting, loading step and boundary condition setting on the eyeball, the eyelid and the surrounding soft tissues thereof, so as to establish a finite element model according to the three-dimensional model and simulate the eye action of the human body through the finite element model.
In one embodiment of the application, the medical image of the human eye comprises a computed tomography medical image of the human eye or a magnetic resonance imaging medical image of the human eye.
In one embodiment of the present application, further comprising: and an optimization module (not shown in fig. 7) for performing an optimization process on the three-dimensional model.
In one embodiment of the present application, the interactive setup of the eyeball, eyelid and surrounding soft tissue by the finite element model building and simulation module 730 includes: a contact arrangement between the eyeball and the tissue structure; a coupling arrangement of the eyelid and its surrounding tissue; rigid body constraint is carried out on the eyeball; the finite element model building and simulation module 730 sets the load steps and their boundary conditions, including: selecting a coupling reference point of an eyelid and a surrounding tissue model; and selecting a rigid body constraint reference point of the eyeball.
According to the modeling and simulation system of the eyes, the rapid and effective modeling of the eye structure of the human body and the calculation of the mechanical behavior of the eye structure under the eyeball rotation can be realized, and therefore a reliable reference basis is provided for medical analysis.
It should be noted that the specific implementation manner of the eye modeling and simulation system in the embodiment of the present application is similar to the specific implementation manner of the eye modeling and simulation method in the embodiment of the present application, and please refer to the description of the method part specifically, which is not described herein again.
The computer-readable storage medium described above may take any combination of one or more computer-readable media. The computer readable medium may be a computer readable signal medium or a computer readable storage medium. A computer readable storage medium may be, for example, but not limited to, an electronic, magnetic, optical, electromagnetic, infrared, or semiconductor system, apparatus, or device, or any combination of the foregoing. More specific examples (a non-exhaustive list) of the computer readable storage medium would include the following: an electrical connection having one or more wires, a portable computer diskette, a hard disk, a Random Access Memory (RAM), a read-only Memory (ROM), an Erasable Programmable read-only Memory (EPROM), a flash Memory, an optical fiber, a portable compact disc read-only Memory (CD-ROM), an optical storage device, a magnetic storage device, or any suitable combination of the foregoing. In the context of this document, a computer readable storage medium may be any tangible medium that can contain, or store a program for use by or in connection with an instruction execution system, apparatus, or device.
A computer readable signal medium may include a propagated data signal with computer readable program code embodied therein, for example, in baseband or as part of a carrier wave. Such a propagated data signal may take any of a variety of forms, including, but not limited to, electro-magnetic, optical, or any suitable combination thereof. A computer readable signal medium may also be any computer readable medium that is not a computer readable storage medium and that can communicate, propagate, or transport a program for use by or in connection with an instruction execution system, apparatus, or device.
Program code embodied on a computer readable medium may be transmitted using any appropriate medium, including but not limited to wireless, wireline, optical fiber cable, RF, etc., or any suitable combination of the foregoing.
Computer program code for carrying out operations for aspects of the present application may be written in any combination of one or more programming languages, including an object oriented programming language such as Java, Smalltalk, C + +, and conventional procedural programming languages, such as the "C" programming language or similar programming languages. The program code may execute entirely on the user's computer, partly on the user's computer, as a stand-alone software package, partly on the user's computer and partly on a remote computer or entirely on the remote computer or server. In the case of a remote computer, the remote computer may be connected to the user's computer through any type of Network, including a Local Area Network (LAN) or a Wide Area Network (WAN), or the connection may be made to an external computer (for example, through the Internet using an Internet service provider).
While embodiments of the present application have been shown and described, it will be understood by those of ordinary skill in the art that: various changes, modifications, substitutions and alterations can be made to the embodiments without departing from the principles and spirit of the application, the scope of which is defined by the claims and their equivalents.
Claims (8)
1. A method of modeling and simulating an eye, comprising:
acquiring a medical image of a human eye;
establishing a three-dimensional model of the eye according to the medical image of the human eye, wherein the three-dimensional model comprises three-dimensional models of an eyeball, an eyelid and surrounding soft tissues of the eyeball and the eyelid;
and carrying out material and parameter setting, interactive setting, loading step and boundary condition setting on the eyeballs, the eyelids and the surrounding soft tissues thereof so as to establish a finite element model according to the three-dimensional model and simulate the human eye action through the finite element model.
2. The method of claim 1, wherein the medical image of the human eye comprises a computed tomography medical image of the human eye or a magnetic resonance imaging medical image of the human eye.
3. The method of modeling and simulating an eye according to claim 1, further comprising, prior to establishing the finite element model: and optimizing the three-dimensional model.
4. The method for modeling and simulating the eye according to any of claims 1-3 wherein the interactive setup of the eyeball, eyelid and surrounding soft tissue comprises:
a contact arrangement between the eyeball and the tissue structure;
a coupling arrangement of the eyelid and its surrounding tissue;
rigid body constraint is carried out on the eyeball;
the setting of the load steps and the boundary conditions thereof comprises the following steps:
selecting a coupling reference point of an eyelid and a surrounding tissue model;
and selecting a rigid body constraint reference point of the eyeball.
5. A modeling and simulation system for an eye, comprising:
the acquisition module is used for acquiring a medical image of the human eyes;
the three-dimensional model establishing module is used for establishing a three-dimensional model of the eye according to the medical image of the human eye, wherein the three-dimensional model comprises three-dimensional models of an eyeball, an eyelid and surrounding soft tissues;
and the finite element model establishing and simulating module is used for carrying out material and parameter setting, interactive setting, loading step and boundary condition setting on the eyeballs, the eyelids and the surrounding soft tissues thereof so as to establish a finite element model according to the three-dimensional model and simulate the eye action of the human body through the finite element model.
6. The system for modeling and simulating an eye according to claim 5 wherein the medical image of a human eye comprises a computed tomography medical image of a human eye or a magnetic resonance imaging medical image of a human eye.
7. The ocular modeling and simulation system of claim 5, further comprising:
and the optimization module is used for optimizing the three-dimensional model.
8. The modeling and simulation system for the eye according to any of claims 5-7, wherein the finite element modeling and simulation module for interactive setup of the eyeball, eyelid and surrounding soft tissue comprises: a contact arrangement between the eyeball and the tissue structure; a coupling arrangement of the eyelid and its surrounding tissue; rigid body constraint is carried out on the eyeball; the finite element model building and simulating module sets the loading step and the boundary condition thereof, and comprises the following steps: selecting a coupling reference point of an eyelid and a surrounding tissue model; and selecting a rigid body constraint reference point of the eyeball.
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN111667906A (en) * | 2020-06-15 | 2020-09-15 | 上海交通大学医学院附属仁济医院 | Eyeball structure virtual teaching system and digital model establishing method thereof |
| CN115100380A (en) * | 2022-06-17 | 2022-09-23 | 上海新眼光医疗器械股份有限公司 | Medical image automatic identification method based on eye body surface feature points |
| CN116822260A (en) * | 2023-08-31 | 2023-09-29 | 天河超级计算淮海分中心 | Eyeball simulation method based on numerical conversion, electronic equipment and storage medium |
-
2020
- 2020-01-13 CN CN202010032479.2A patent/CN111128367A/en active Pending
Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN111667906A (en) * | 2020-06-15 | 2020-09-15 | 上海交通大学医学院附属仁济医院 | Eyeball structure virtual teaching system and digital model establishing method thereof |
| CN111667906B (en) * | 2020-06-15 | 2024-02-13 | 上海交通大学医学院附属仁济医院 | Eyeball structure virtual teaching system and digital model building method thereof |
| CN115100380A (en) * | 2022-06-17 | 2022-09-23 | 上海新眼光医疗器械股份有限公司 | Medical image automatic identification method based on eye body surface feature points |
| CN115100380B (en) * | 2022-06-17 | 2024-03-26 | 上海新眼光医疗器械股份有限公司 | Automatic medical image identification method based on eye body surface feature points |
| CN116822260A (en) * | 2023-08-31 | 2023-09-29 | 天河超级计算淮海分中心 | Eyeball simulation method based on numerical conversion, electronic equipment and storage medium |
| CN116822260B (en) * | 2023-08-31 | 2023-11-17 | 天河超级计算淮海分中心 | Eyeball simulation method based on numerical conversion, electronic equipment and storage medium |
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