CN111121188A - Radiopharmaceutical split charging hot chamber - Google Patents
Radiopharmaceutical split charging hot chamber Download PDFInfo
- Publication number
- CN111121188A CN111121188A CN202010025578.8A CN202010025578A CN111121188A CN 111121188 A CN111121188 A CN 111121188A CN 202010025578 A CN202010025578 A CN 202010025578A CN 111121188 A CN111121188 A CN 111121188A
- Authority
- CN
- China
- Prior art keywords
- drawer
- door
- medicine
- air
- inner container
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 229940121896 radiopharmaceutical Drugs 0.000 title claims description 25
- 239000012217 radiopharmaceutical Substances 0.000 title claims description 25
- 230000002799 radiopharmaceutical effect Effects 0.000 title claims description 25
- 239000003814 drug Substances 0.000 claims abstract description 167
- 229940079593 drug Drugs 0.000 claims abstract description 34
- 230000001681 protective effect Effects 0.000 claims abstract description 28
- 230000005855 radiation Effects 0.000 claims description 42
- 238000007789 sealing Methods 0.000 claims description 25
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 claims description 19
- 230000000007 visual effect Effects 0.000 claims description 6
- 230000002285 radioactive effect Effects 0.000 abstract description 14
- 238000000034 method Methods 0.000 abstract description 9
- 230000003749 cleanliness Effects 0.000 abstract description 7
- 230000008569 process Effects 0.000 abstract description 7
- 230000006378 damage Effects 0.000 abstract description 6
- 238000013461 design Methods 0.000 abstract description 5
- 238000000746 purification Methods 0.000 abstract description 5
- 238000007599 discharging Methods 0.000 description 17
- 230000007246 mechanism Effects 0.000 description 12
- 238000012544 monitoring process Methods 0.000 description 10
- 230000000694 effects Effects 0.000 description 5
- 238000004519 manufacturing process Methods 0.000 description 5
- 238000002955 isolation Methods 0.000 description 4
- 238000009423 ventilation Methods 0.000 description 4
- 230000009471 action Effects 0.000 description 3
- 238000004887 air purification Methods 0.000 description 3
- 230000007613 environmental effect Effects 0.000 description 3
- 238000004891 communication Methods 0.000 description 2
- 238000011161 development Methods 0.000 description 2
- 238000009206 nuclear medicine Methods 0.000 description 2
- 238000011160 research Methods 0.000 description 2
- 239000000523 sample Substances 0.000 description 2
- 230000009286 beneficial effect Effects 0.000 description 1
- 230000015572 biosynthetic process Effects 0.000 description 1
- 229910052799 carbon Inorganic materials 0.000 description 1
- 230000007547 defect Effects 0.000 description 1
- 238000010586 diagram Methods 0.000 description 1
- 238000012377 drug delivery Methods 0.000 description 1
- 230000002349 favourable effect Effects 0.000 description 1
- 238000011068 loading method Methods 0.000 description 1
- 238000007726 management method Methods 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 238000002360 preparation method Methods 0.000 description 1
- 238000012545 processing Methods 0.000 description 1
- 238000003904 radioactive pollution Methods 0.000 description 1
- 238000006467 substitution reaction Methods 0.000 description 1
- 238000003786 synthesis reaction Methods 0.000 description 1
- 230000007306 turnover Effects 0.000 description 1
Images
Classifications
-
- F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
- F24—HEATING; RANGES; VENTILATING
- F24F—AIR-CONDITIONING; AIR-HUMIDIFICATION; VENTILATION; USE OF AIR CURRENTS FOR SCREENING
- F24F3/00—Air-conditioning systems in which conditioned primary air is supplied from one or more central stations to distributing units in the rooms or spaces where it may receive secondary treatment; Apparatus specially designed for such systems
- F24F3/12—Air-conditioning systems in which conditioned primary air is supplied from one or more central stations to distributing units in the rooms or spaces where it may receive secondary treatment; Apparatus specially designed for such systems characterised by the treatment of the air otherwise than by heating and cooling
- F24F3/16—Air-conditioning systems in which conditioned primary air is supplied from one or more central stations to distributing units in the rooms or spaces where it may receive secondary treatment; Apparatus specially designed for such systems characterised by the treatment of the air otherwise than by heating and cooling by purification, e.g. by filtering; by sterilisation; by ozonisation
- F24F3/167—Clean rooms, i.e. enclosed spaces in which a uniform flow of filtered air is distributed
-
- F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
- F24—HEATING; RANGES; VENTILATING
- F24F—AIR-CONDITIONING; AIR-HUMIDIFICATION; VENTILATION; USE OF AIR CURRENTS FOR SCREENING
- F24F11/00—Control or safety arrangements
- F24F11/50—Control or safety arrangements characterised by user interfaces or communication
- F24F11/52—Indication arrangements, e.g. displays
-
- F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
- F24—HEATING; RANGES; VENTILATING
- F24F—AIR-CONDITIONING; AIR-HUMIDIFICATION; VENTILATION; USE OF AIR CURRENTS FOR SCREENING
- F24F11/00—Control or safety arrangements
- F24F11/50—Control or safety arrangements characterised by user interfaces or communication
- F24F11/52—Indication arrangements, e.g. displays
- F24F11/526—Indication arrangements, e.g. displays giving audible indications
-
- F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
- F24—HEATING; RANGES; VENTILATING
- F24F—AIR-CONDITIONING; AIR-HUMIDIFICATION; VENTILATION; USE OF AIR CURRENTS FOR SCREENING
- F24F13/00—Details common to, or for air-conditioning, air-humidification, ventilation or use of air currents for screening
- F24F13/28—Arrangement or mounting of filters
-
- F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
- F24—HEATING; RANGES; VENTILATING
- F24F—AIR-CONDITIONING; AIR-HUMIDIFICATION; VENTILATION; USE OF AIR CURRENTS FOR SCREENING
- F24F7/00—Ventilation
- F24F7/04—Ventilation with ducting systems, e.g. by double walls; with natural circulation
- F24F7/06—Ventilation with ducting systems, e.g. by double walls; with natural circulation with forced air circulation, e.g. by fan positioning of a ventilator in or against a conduit
- F24F7/08—Ventilation with ducting systems, e.g. by double walls; with natural circulation with forced air circulation, e.g. by fan positioning of a ventilator in or against a conduit with separate ducts for supplied and exhausted air with provisions for reversal of the input and output systems
-
- F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
- F24—HEATING; RANGES; VENTILATING
- F24F—AIR-CONDITIONING; AIR-HUMIDIFICATION; VENTILATION; USE OF AIR CURRENTS FOR SCREENING
- F24F8/00—Treatment, e.g. purification, of air supplied to human living or working spaces otherwise than by heating, cooling, humidifying or drying
- F24F8/10—Treatment, e.g. purification, of air supplied to human living or working spaces otherwise than by heating, cooling, humidifying or drying by separation, e.g. by filtering
- F24F8/108—Treatment, e.g. purification, of air supplied to human living or working spaces otherwise than by heating, cooling, humidifying or drying by separation, e.g. by filtering using dry filter elements
-
- F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
- F24—HEATING; RANGES; VENTILATING
- F24F—AIR-CONDITIONING; AIR-HUMIDIFICATION; VENTILATION; USE OF AIR CURRENTS FOR SCREENING
- F24F8/00—Treatment, e.g. purification, of air supplied to human living or working spaces otherwise than by heating, cooling, humidifying or drying
- F24F8/10—Treatment, e.g. purification, of air supplied to human living or working spaces otherwise than by heating, cooling, humidifying or drying by separation, e.g. by filtering
- F24F8/15—Treatment, e.g. purification, of air supplied to human living or working spaces otherwise than by heating, cooling, humidifying or drying by separation, e.g. by filtering by chemical means
- F24F8/158—Treatment, e.g. purification, of air supplied to human living or working spaces otherwise than by heating, cooling, humidifying or drying by separation, e.g. by filtering by chemical means using active carbon
-
- G—PHYSICS
- G21—NUCLEAR PHYSICS; NUCLEAR ENGINEERING
- G21F—PROTECTION AGAINST X-RADIATION, GAMMA RADIATION, CORPUSCULAR RADIATION OR PARTICLE BOMBARDMENT; TREATING RADIOACTIVELY CONTAMINATED MATERIAL; DECONTAMINATION ARRANGEMENTS THEREFOR
- G21F5/00—Transportable or portable shielded containers
- G21F5/015—Transportable or portable shielded containers for storing radioactive sources, e.g. source carriers for irradiation units; Radioisotope containers
-
- F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
- F24—HEATING; RANGES; VENTILATING
- F24F—AIR-CONDITIONING; AIR-HUMIDIFICATION; VENTILATION; USE OF AIR CURRENTS FOR SCREENING
- F24F2110/00—Control inputs relating to air properties
- F24F2110/50—Air quality properties
- F24F2110/65—Concentration of specific substances or contaminants
Landscapes
- Engineering & Computer Science (AREA)
- Chemical & Material Sciences (AREA)
- General Engineering & Computer Science (AREA)
- Combustion & Propulsion (AREA)
- Mechanical Engineering (AREA)
- Human Computer Interaction (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Physics & Mathematics (AREA)
- High Energy & Nuclear Physics (AREA)
- Measurement Of Radiation (AREA)
Abstract
The invention discloses a radioactive drug split charging hot chamber which comprises an outer box body and an inner container positioned in the outer box body, wherein a protective door, a drug inlet drawer and a drug outlet drawer are respectively arranged on the front side wall of the outer box body, the protective door corresponds to the inner container, the drug inlet drawer and the drug outlet drawer are both positioned below the inner container, an operating hand hole is formed in the protective door, an operating glove which extends into the inner container and corresponds to the operating hand hole is arranged on the front side wall of the inner container, a drug inlet inner door and a drug outlet inner door are respectively arranged on the bottom wall of the inner container, the drug inlet inner door corresponds to the drug inlet drawer, the drug outlet inner door corresponds to the drug outlet drawer, and an air inlet and exhaust system is arranged on the outer box body. The air cleanliness of the interior can reach hundreds, the quality of nuclide medicines is not affected by the damage of the interior purification environment in the normal operation process, the structural design is reasonable, the operation is safe and convenient, and the functions meet the industrial specifications.
Description
Technical Field
The invention relates to the technical field of radioactive drug subpackage, in particular to a radioactive drug subpackage hot chamber.
Background
With the rapid development of nuclear medicine, equipment for radionuclide drug production and related operations is widely used, and a hot chamber is one of them. The hot chamber is high radiation protection equipment which provides effective protection places for corresponding operation or core equipment during production and subpackage of the radionuclide medicine. How the hot chamber makes each item operation requirement of equipment accord with the trade standard under the prerequisite of guaranteeing protection safety, can make personnel's operation use more reasonable more convenient simultaneously is the direction of equipment research development.
The radioactive drug subpackaging hot chamber (simply called hot chamber) is widely applied to large hospital nuclear medicine, radioactive drug production mechanisms and radioactive drug research mechanisms, is used for subpackaging 18F-FDG and other radioactive drugs, and can enable medical workers to be far away from radioactive sources in the drug subpackaging process and reduce the radiation received by the medical workers.
The existing radiopharmaceutical split charging hot chamber has the following defects:
1) the structural design is unreasonable, and the operation is inconvenient;
2) the air intake and exhaust system is basically designed in a vertical laminar flow structure, and a fan is adopted to control the flow direction of air in an inner cavity (namely an inner container) of the equipment, about 70 percent of air flows back into the inner cavity, and 30 percent of air is discharged outside. The structure is controlled by a single fan, so that the ventilation thoroughness of gas in the cavity and the stability of the internal pressure state are difficult to ensure;
3) the radiation protection effect is poor, and the safety of a user is difficult to effectively ensure;
4) the radiation monitoring and alarming function is not available, and the radiation overproof alarming function can not be provided for the user well.
An effective solution to the problems in the related art has not been proposed yet.
Disclosure of Invention
Aiming at the technical problems in the related art, the invention provides the radiopharmaceutical subpackage hot chamber which is reasonable in structural design, safe and convenient to operate and good in radiation protection effect, the operation is convenient, the functions meet the industrial specifications, the gas flow direction is controlled by adopting the double fans, so that the stability of the gas state in the inner container of the hot chamber is ensured, the internal pressure condition and the gas ventilation frequency meet the requirements of the related specifications, the safety of a user can be effectively ensured, and the radiopharmacy hot chamber has the radiation monitoring and alarming functions.
In order to achieve the technical purpose, the technical scheme of the invention is realized as follows:
the utility model provides a radiopharmaceutical partial shipment hot chamber, includes the outer box and is located the inner bag of outer box inside, be provided with the guard gate on the preceding lateral wall of outer box respectively, advance the medicine drawer and go out the medicine drawer, the guard gate with the inner bag is corresponding, advance the medicine drawer with it all is located to go out the medicine drawer the below of inner bag, the operation hand hole has been seted up on the guard gate, be provided with on the preceding lateral wall of inner bag and stretch into the inside of inner bag and with the corresponding operating glove in operation hand hole, be provided with respectively on the diapire of inner bag and advance the medicine inner door and go out the medicine inner door, advance the medicine inner door with it is corresponding to advance the medicine drawer, go out the medicine inner door with it is corresponding to go out the medicine drawer, be provided with into the air exhaust system on the outer box.
Further, advance exhaust system and include air-supply line and exhaust pipe, the air-supply line runs through downwards communicate behind the roof of outer box the inside of inner bag, the intercommunication is provided with at least one vent on the inner bag, the vent is located the below of air-supply line, the inside of outer box be provided with the corresponding passageway of airing exhaust of vent, the exhaust pipe intercommunication the passageway of airing exhaust, be provided with air intake fan on the air-supply line, be provided with the fan of airing exhaust on the exhaust pipe.
Further, still be provided with primary filter and HEPA high efficiency filter on the air-supply line, primary filter is located the outside of outer box, air intake fan with HEPA high efficiency filter all is located the inside of outer box, air intake fan is located primary filter with between the HEPA high efficiency filter, still be provided with activated carbon filter on the exhaust pipe, activated carbon filter is located the inside of outer box, the fan of airing exhaust is located the outside of outer box.
Furthermore, gaps are arranged between the bottom wall of the outer box body and the bottom wall of the inner container and between the rear side wall of the outer box body and the rear side wall of the inner container, and the two gaps are communicated with each other to form the air exhaust channel.
Furthermore, valves are arranged on the air inlet pipe and the air exhaust pipe.
Further, a radiation detector is arranged in the inner container and connected with a PLC (programmable logic controller), the PLC is respectively connected with an audible and visual alarm and a protective door electric lock, and the protective door electric lock corresponds to the protective door.
Furthermore, the outside of outer box is provided with lead shielding shell, lead shielding shell is last to be seted up a plurality of respectively with the guard gate, advance the medicine drawer with go out the window of medicine drawer one-to-one.
Further, be provided with two drawer shells in the outer box body, the preceding lateral wall of drawer shell has seted up and has supplied advance the medicine drawer or go out the first opening of medicine drawer business turn over, the second opening has been seted up to the roof of drawer shell, second opening sealing connection advance the medicine inner door or go out the medicine inner door, advance on the medicine drawer, go out on the medicine drawer, advance on the medicine inner door and go out and all be provided with inflatable seal on the medicine inner door.
Furthermore, the drawer shell is communicated with the inner container through an air inlet pipe, the drawer shell is communicated with the exhaust channel through an exhaust pipe, and valves are arranged on the air inlet pipe and the exhaust pipe.
Furthermore, the medicine inlet inner door and the medicine outlet inner door respectively comprise a door body and a door frame, the door frame is fixedly connected with the inner container, the door frame is hinged with the door body through a hinge, and the door frame is fixedly connected with the inflatable sealing ring corresponding to the door body.
The invention has the beneficial effects that: the utility model has the advantages of can make inside air cleanliness reach hundred grades, and need not worry that inside purifying environment can receive destruction and influence the quality of nuclide medicine in normal operation in-process, structural design is reasonable, the operation is safe convenient, the function accords with the trade standard, adopt two fans to control the gas flow direction and set up corresponding filter, guaranteed that hot indoor air quality and state are stable in the state that accords with the operational environment requirement, the environmental safety of radiopharmaceutical production and corresponding operation has been guaranteed, it accords with corresponding law and regulation and trade standard to have guaranteed hot room performance, the radiation protection effect is good, can effectively guarantee user's safety, radiation monitoring and alarming function have, be favorable to managers to master relevant circumstances in real time, be convenient for look for the problem, make radiopharmaceutical partial shipment hot chamber safe and reliable more.
Drawings
In order to more clearly illustrate the embodiments of the present invention or the technical solutions in the prior art, the drawings needed in the embodiments will be briefly described below, and it is obvious that the drawings in the following description are only some embodiments of the present invention, and it is obvious for those skilled in the art to obtain other drawings without creative efforts.
FIG. 1 is a front view of a radiopharmaceutical dispensing hot chamber according to an embodiment of the present invention;
figure 2 is a cross-sectional view a-a of a radiopharmaceutical dispensing hot chamber according to an embodiment of the present invention;
figure 3 is a cross-sectional view B-B of a radiopharmaceutical dispensing hot chamber according to an embodiment of the present invention;
figure 4 is an exploded view of a radiopharmaceutical dispensing hot chamber according to an embodiment of the present invention;
FIG. 5 is a schematic view of an air intake and exhaust system according to an embodiment of the present invention;
FIG. 6 is a schematic diagram of a radiation monitoring alarm device according to an embodiment of the present invention;
FIG. 7 is a schematic view of a drug loading and unloading mechanism according to an embodiment of the invention;
fig. 8 is an exploded view of the medicine inlet and outlet mechanism according to the embodiment of the invention.
In the figure:
1. an air inlet pipe; 2. an exhaust duct; 3. an outer case; 4. an inner container; 5. a vent; 6. an air exhaust channel; 7. an air intake fan; 8. a primary filter; 9. a HEPA high efficiency filter; 10. an activated carbon filter; 11. an exhaust fan; 12. a protective door; 13. a medicine feeding drawer; 14. a medicine outlet drawer; 15. an inner medicine inlet door; 16. an inner medicine outlet door; 17. a lead shield shell; 18. a drawer shell; 19. an inflatable seal ring; 20. an air inlet pipe; 21. an exhaust pipe; 22. an audible and visual alarm; 23. a touch screen; 24. a protective cover.
Detailed Description
The technical solutions in the embodiments of the present invention will be clearly and completely described below with reference to the drawings in the embodiments of the present invention, and it is obvious that the described embodiments are only a part of the embodiments of the present invention, and not all of the embodiments. All other embodiments that can be derived by one of ordinary skill in the art from the embodiments given herein are intended to be within the scope of the present invention.
Referring to fig. 1 to 8, a radiopharmaceutical dispensing hot chamber according to an embodiment of the present invention includes an outer case 3 and an inner container 4 disposed inside the outer case 3, a protective door 12, a medicine inlet drawer 13 and a medicine outlet drawer 14 are respectively arranged on the front side wall of the outer box body 3, the protective door 12 corresponds to the inner container 4, the medicine inlet drawer 13 and the medicine outlet drawer 14 are both positioned below the inner container 4, an operating hand hole is arranged on the protective door 12, an operating glove which extends into the inner container 4 and corresponds to the operating hand hole is arranged on the front side wall of the inner container 4, the bottom wall of the inner container 4 is respectively provided with a medicine inlet inner door 15 and a medicine outlet inner door 16, the medicine inlet inner door 15 corresponds to the medicine inlet drawer 13, the medicine outlet inner door 16 corresponds to the medicine outlet drawer 14, and an air inlet and exhaust system is arranged on the outer box body 3.
In a specific embodiment of the present invention, the air intake and exhaust system includes an air intake pipe 1 and an air exhaust pipe 2, the air intake pipe 1 downwardly penetrates through the top wall of the outer box 3 and then communicates with the inside of the inner container 4, the inner container 4 is communicated with at least one vent 5, the vent 5 is located below the air intake pipe 1, the inside of the outer box 3 is provided with an air exhaust channel 6 corresponding to the vent 5, the air exhaust pipe 2 communicates with the air exhaust channel 6, the air intake pipe 1 is provided with an air intake fan 7, and the air exhaust pipe 2 is provided with an air exhaust fan 11.
In a specific embodiment of the present invention, a primary filter 8 and a HEPA high efficiency filter 9 are further disposed on the air inlet pipe 1, the primary filter 8 is located outside the outer box 3, the air inlet fan 7 and the HEPA high efficiency filter 9 are both located inside the outer box 3, the air inlet fan 7 is located between the primary filter 8 and the HEPA high efficiency filter 9, the air outlet pipe 2 is further provided with an activated carbon filter 10, the activated carbon filter 10 is located inside the outer box 3, and the air outlet fan 11 is located outside the outer box 3.
In an embodiment of the present invention, gaps are disposed between the bottom wall of the outer box 3 and the bottom wall of the inner container 4 and between the rear sidewall of the outer box 3 and the rear sidewall of the inner container 4, and the two gaps are communicated with each other to form the air exhaust channel 6.
In an embodiment of the present invention, valves are disposed on the air inlet pipe 1 and the air outlet pipe 2.
In a specific embodiment of the present invention, a radiation detector is disposed in the inner container 4, the radiation detector is connected to a PLC controller, the PLC controller is respectively connected to an audible and visual alarm 22 and a protective door electric lock, and the protective door electric lock corresponds to the protective door 12.
In an embodiment of the present invention, a lead shielding case 17 is disposed outside the outer box 3, and a plurality of windows corresponding to the protection door 12, the medicine inlet drawer 13, and the medicine outlet drawer 14 are formed on the lead shielding case 17.
In a specific embodiment of the present invention, two drawer cases 18 are disposed in the outer box 3, a first opening through which the medicine inlet drawer 13 or the medicine outlet drawer 14 can enter and exit is disposed on a front side wall of each drawer case 18, a second opening is disposed on a top wall of each drawer case 18, the second opening is hermetically connected to the medicine inlet inner door 15 or the medicine outlet inner door 16, and the medicine inlet drawer 13, the medicine outlet drawer 14, the medicine inlet inner door 15, and the medicine outlet inner door 16 are all provided with an inflatable sealing ring 19.
In an embodiment of the present invention, the drawer housing 18 is connected to the inner container 4 through an air inlet pipe 20, the drawer housing 18 is connected to the exhaust duct 6 through an exhaust pipe 21, and both the air inlet pipe 20 and the exhaust pipe 21 are provided with valves.
In a specific embodiment of the present invention, each of the medicine inlet inner door 15 and the medicine outlet inner door 16 includes a door body and a door frame, the door frame is fixedly connected to the inner container 4, the door frame is hinged to the door body through a hinge, and the door frame is fixedly connected to the inflatable sealing ring 19 corresponding to the door body.
In order to facilitate understanding of the above-described embodiments of the present invention, the following detailed description of the embodiments of the present invention is provided by way of specific usage.
The synthesis and the subpackage process of the radionuclide drug are carried out under strict environmental requirements, the air cleanliness of the environment for installing and using corresponding equipment must reach ten thousand-level purification, and the air cleanliness of the interior of the equipment for subpackaging the drug has higher requirement and must reach hundred-level purification. The radiopharmaceutical dispensing hot chamber must have the ability to keep the interior cavity air clean and at a level of hundreds of days. Therefore, the radioactive drug subpackaging hot chamber is provided with the air inlet and exhaust system, the drug inlet and outlet mechanism, the inflatable sealing ring 19 and other structures, and the air purification degree in the inner container 4 can not be damaged when a user operates the radioactive drug subpackaging hot chamber in the whole working process.
The radioactive drug subpackaging hot chamber (also called as a radioactive drug subpackaging hot chamber protection box and the like) comprises an outer box body 3, an inner container 4, a lead shielding shell 17, an air inlet and exhaust system, a drug inlet and outlet mechanism and a radiation monitoring alarm device.
The lead shielding shell 17 can play a role in protection, and can effectively prevent radiation damage, thereby effectively protecting the safety of a user. The thickness of the lead shielding shell 17 is determined according to the maximum dose of the radionuclide drug, and the radiation shielding capability thereof is generally not lower than 60 mmPb. The lead shielding case 17 is composed of six lead plates, the lead equivalent of the lead plates meets the standard requirement after being measured by a method of GBZ/T147-2002 'determination of attenuation performance of X-ray protection material', and the contact surfaces are overlapped when the lead plates are installed so as to ensure that all directions are protected by radiation and avoid possible radiation leakage of the lead shielding case 17. The lead shielding shell 17 not only provides safe and reliable protection for medical staff, but also protects the surrounding environment of the equipment from radioactive pollution.
The inner container 4 is equipped with in the inside of outer box 3, and mountable split charging mechanism in the inner container 4 is equipped with guard gate 12 on the outer box 3, is provided with the sealing door corresponding with guard gate 12 on the inner container 4, all is provided with inflatable seal 19 between sealing door and the inner container 4 and between guard gate 12 and the outer box 3. The protective door 12 is provided with an observation window and two operation hand holes, the protective door 12 is also hinged with a protective cover 24 which can cover the operation hand holes, the sealing door of the inner container 4 is transparent or the opaque sealing door can be provided with the observation window, so that a user can observe the internal condition of the inner container 4. Be provided with the interior door 15 of advancing medicine and going out the medicine inner door 16 that all can open and shut on the diapire of inner bag 4, be provided with two operation gloves on the inner bag 4, the user can pass the arm behind the operation hand hole after opening the protective cover and stretch into operation gloves, through the inside partial shipment mechanism of operation gloves operatable inner bag 4 to can manually open and close advance medicine inner door 15 and go out medicine inner door 16. The medicine inlet inner door 15 and the medicine outlet inner door 16 both comprise door bodies and door frames. The door frame is sealed with the door body through the inflatable sealing ring 19.
The air intake and exhaust system has an air purification function, and can ensure that the air cleanliness inside the inner container 4 reaches class 100.
The radiation monitoring alarm device can display the radiation quantity in the inner container 4 in a digitalized information manner, and is provided with an alarm device and a linkage locking device after the value exceeds the standard, so that a user can know and prevent possible damage.
The medicine inlet and outlet mechanism comprises a medicine inlet drawer 13 and a medicine outlet drawer 14, the front side wall of the medicine inlet drawer 13 serves as a medicine inlet outer door, the area of the medicine inlet outer door is larger than the first opening of the drawer shell 18, the front side wall of the medicine outlet drawer 14 serves as a medicine outlet outer door, and the area of the medicine outlet outer door is larger than the first opening of the drawer shell 18. And the rear side wall of the medicine inlet outer door and the rear side wall of the medicine outlet outer door are both provided with an inflatable sealing ring 19. The outer box body 3 is provided with electric locks which are respectively corresponding to the medicine inlet outer door and the medicine outlet outer door one to one. The electric lock is connected with the PLC.
The outer box body 3, the lead shielding shell 17 and the inner container 4 are basic composition structures, and the air intake and exhaust system is a structure and power for providing clean air and keeping ventilation volume for the inner container 4; the inflatable sealing ring 19 ensures the sealing effect, so that the air quality in the inner container 4 can not be influenced by the outside air; the medicine inlet and outlet mechanism ensures that the air cleanliness of the outer liner 4 cannot be broken by external air when medicine inlet and outlet operations are carried out; the radiation monitoring alarm device is used for reminding a user of the internal condition and the danger degree and providing a necessary isolation locking means.
The air inlet and exhaust system comprises an air inlet pipe 1 and an air exhaust pipe 2, an air inlet fan 7, a primary filter 8 and an HEPA high-efficiency filter 9 are arranged on the air inlet pipe 1, and an air exhaust fan 11 and an active carbon filter 10 are arranged on the air exhaust pipe 2. The bottom wall of the inner container 4 and the lower part of the rear side wall of the inner container 4 are provided with ventilation openings 5. The bottom wall of the inner container 4, the rear side wall of the inner container 4, the bottom wall of the outer box 3 and the rear side wall of the outer box 3 jointly enclose an exhaust channel 6, and the exhaust channel 6 is respectively communicated with the vent 5 and the exhaust pipe 2.
When the air inlet and exhaust system is used specifically, under the action of the air inlet fan 7, the air inlet pipe 1 filters external air through the primary filter 8 and the HEPA high-efficiency filter 9 and then sends the filtered air into the inner container 4, and air inlet work is finished; under the action of the exhaust fan 11, the air inside the liner 4 is firstly exhausted into the exhaust channel 6 through the vents 5 on the bottom wall and the rear side wall, then is exhausted into the exhaust duct 2 through the exhaust channel 6, and finally is exhausted to the outside (generally connected with a special exhaust duct) after being filtered by the activated carbon filter 10, and the air flow direction is controlled by arranging the air intake fan 7 and the exhaust fan 11, so that the air pressure and the clean state inside the liner 4 can be maintained in a relatively stable state meeting the requirements. In order to enable the air flow in and out of the inner container 4 to be more controllable, the air inlet pipe 1 and the air outlet pipe 2 are respectively provided with a valve capable of adjusting the flow, so that the air pressure in the inner container 4 is adjusted by adjusting the valves, and the inside of the inner container 4 is better maintained in a negative pressure state.
The radiation monitoring and alarming device is based on an original control system, a radiation probe (namely a radiation detector) and a 4-20 mA communication cable and the like are added, the radiation quantity in an inner container in the process of subpackaging and processing the radiopharmaceuticals is converted into a linear analog quantity measuring value, the linear analog quantity measuring value is transmitted to a PLC (programmable logic controller) through a 4-20 mA signal, the PLC linearly converts the radiation quantity into a corresponding radiation dosage value and compares the radiation dosage value with a set value, if the radiation dosage value exceeds the set value, an alarm signal is sent to an audible and visual alarm 22 (the model is DC-SG 110), and the electric lock of a protective door is controlled through a DC24V control line to act so as to lock the protective.
The control system comprises a PLC controller. The PLC controller is SIEMENS S7-200. The PLC is connected with the touch screen 23 through a gateway and a network cable, and the model of the touch screen 23 is SIEMENS TP 1200. The electric lock of the guard door and the electric lock are both of the type SYL 60S.
The radiation detector is a gamma radiation detector, and the model of the gamma radiation detector is DH 50.
When the radiation monitoring and alarming device is used specifically, gamma rays of radioactive drugs in the liner are detected in real time through the radiation detector (namely, the radiation probe), data are transmitted to the PLC through RS485 communication, the data are displayed on the touch screen in real time after being converted into radiation dose values through the PLC, the radiation dose values are compared with set values through the PLC, if the radiation dose values exceed the set values, an alarming signal is sent to the audible and visual alarm 22, the electric lock action of the protective door is controlled, the protective door is locked, the internal condition and the danger degree of the liner of a user can be reminded, the user can know and prevent possible damage of the liner, and necessary isolation locking means are provided to protect the safety of the user.
The medicine feeding and discharging mechanism comprises a drawer shell 18, the left side wall or the right side wall of the drawer shell 18 is fixedly connected with an air inlet pipe 20 and an exhaust pipe 21 through flanges respectively, the drawer shell 18 is communicated with the air inlet pipe 20 and the exhaust pipe 21 respectively, a slidable drawer (namely, a medicine feeding drawer 13 or a medicine discharging drawer 14) is arranged in the drawer shell 18, the front side wall of the drawer shell 18 is provided with a first opening for the drawer to go in and out, the front side wall of the drawer serves as an outer door (namely, a medicine feeding outer door or a medicine discharging outer door), the edge of the outer door is attached to the edge of the first opening through an inflatable sealing ring 19, the top wall of the drawer shell 18 is provided with a second opening, the second opening is provided with an inner door (namely, the medicine feeding inner door 15 or the medicine discharging inner door 16), the inner door comprises a door body and a door frame, the door frame is fixed on the inner container 4. Valves are provided in both the inlet pipe 20 and the outlet pipe 21. The front side of the outer door is provided with a handle.
When the medicine inlet and outlet mechanism is used specifically, during medicine inlet, the medicine inlet outer door is opened firstly, the medicine inlet drawer 13 is pulled out, the medicine can is placed at the designated position of the medicine inlet drawer 13, the medicine inlet drawer 13 is pushed in, the medicine inlet outer door is closed, at the moment, the inflatable sealing ring 19 at the medicine inlet outer door is inflated and sealed, air purification is started in the drawer shell 18 where the medicine inlet drawer 13 is located, when the purification time reaches the preset time, the inflatable sealing ring 19 at the medicine inlet inner door 15 is exhausted to finish the sealing state, the medicine inlet inner door 15 is opened, the medicine can in the medicine inlet drawer 13 is taken into the inner container 4, the medicine inlet inner door 15 is closed, and the medicine inlet process is finished; when the medicine is discharged, the air in the drawer shell 18 where the medicine discharging drawer 14 is located is in a purification state, the medicine discharging inner door 16 is opened, the medicine can is placed at the designated position of the medicine discharging drawer 14, the medicine discharging inner door 16 is closed, the inflatable sealing ring 19 at the medicine discharging inner door 16 is inflated and sealed at the moment, the medicine discharging outer door is opened, the medicine discharging drawer 14 is pulled out, the medicine can in the medicine discharging drawer 14 is taken out, the medicine discharging drawer 14 is pushed into and the medicine discharging outer door is closed after the medicine discharging is completed, the inflatable sealing ring 19 at the medicine discharging outer door is inflated and sealed at the moment, the air in the drawer shell 18 where the medicine discharging drawer 14 is located begins to be purified, and preparation is made for the next operation.
In conclusion, by means of the technical scheme, the cleanliness of the air in the nuclear nuclide drug delivery system can reach hundreds, the quality of the nuclide drug is not affected by damage of the internal purified environment in the normal operation process, the structural design is reasonable, the operation is safe and convenient, and the function meets the industrial specification. The double fans (namely the air inlet fan and the air exhaust fan) are adopted to control the flow direction of the gas and are provided with corresponding filters (namely a primary filter, an HEPA high-efficiency filter and an activated carbon filter), so that the quality and the state of the air in the hot chamber are ensured to be stable in a state meeting the requirements of the working environment, the environmental safety of the production and the corresponding operation of the radioactive medicament is ensured, and the service performance of the hot chamber is ensured to meet the corresponding laws and regulations and industrial specifications. The radiation protection effect is good, the safety of a user can be effectively guaranteed, the radiation monitoring and alarming functions are realized, management personnel can master related conditions in real time, problems can be conveniently found, and the radiopharmaceutical subpackaging hot chamber is safer and more reliable.
The present invention is not limited to the above preferred embodiments, and any modifications, equivalent substitutions, improvements, etc. within the spirit and principle of the present invention should be included in the protection scope of the present invention.
Claims (10)
1. The radiopharmaceutical split charging hot chamber comprises an outer box body (3) and an inner container (4) positioned inside the outer box body (3), and is characterized in that a protective door (12), a medicine inlet drawer (13) and a medicine outlet drawer (14) are respectively arranged on the front side wall of the outer box body (3), the protective door (12) corresponds to the inner container (4), the medicine inlet drawer (13) and the medicine outlet drawer (14) are both positioned below the inner container (4), an operating hand hole is formed in the protective door (12), an operating glove which extends into the inner container (4) and corresponds to the operating hand hole is arranged on the front side wall of the inner container (4), a medicine inlet inner door (15) and a medicine outlet inner door (16) are respectively arranged on the bottom wall of the inner container (4), the medicine inlet inner door (15) corresponds to the medicine inlet drawer (13), the medicine outlet inner door (16) corresponds to the medicine outlet drawer (14), and an air inlet and exhaust system is arranged on the outer box body (3).
2. The radiopharmaceutical subpackaging hot chamber according to claim 1, wherein the air intake and exhaust system comprises an air intake pipe (1) and an air exhaust pipe (2), the air intake pipe (1) penetrates through the top wall of the outer box (3) downwards and then is communicated with the inside of the inner container (4), at least one vent (5) is communicated with the inner container (4), the vent (5) is located below the air intake pipe (1), an air exhaust channel (6) corresponding to the vent (5) is arranged in the outer box (3), the air exhaust pipe (2) is communicated with the air exhaust channel (6), an air intake fan (7) is arranged on the air intake pipe (1), and an air exhaust fan (11) is arranged on the air exhaust pipe (2).
3. The radiopharmaceutical subpackaging hot chamber of claim 2, wherein a primary filter (8) and a HEPA high efficiency filter (9) are further arranged on the air inlet pipe (1), the primary filter (8) is arranged outside the outer box body (3), the air inlet fan (7) and the HEPA high efficiency filter (9) are both arranged inside the outer box body (3), the air inlet fan (7) is arranged between the primary filter (8) and the HEPA high efficiency filter (9), the air outlet pipe (2) is further provided with an activated carbon filter (10), the activated carbon filter (10) is arranged inside the outer box body (3), and the air outlet fan (11) is arranged outside the outer box body (3).
4. The radiopharmaceutical dispensing hot chamber as set forth in claim 2, wherein gaps are provided between the bottom wall of the outer box (3) and the bottom wall of the inner container (4) and between the rear side wall of the outer box (3) and the rear side wall of the inner container (4), and the exhaust channel (6) is formed after the two gaps are communicated with each other.
5. The radiopharmaceutical dispensing hot chamber as set forth in claim 2, wherein valves are provided on both the air inlet pipe (1) and the air outlet pipe (2).
6. The radiopharmaceutical dispensing hot chamber as set forth in claim 1, characterized in that a radiation detector is arranged in the inner container (4), the radiation detector is connected with a PLC controller, the PLC controller is respectively connected with an audible and visual alarm (22) and a protective door electric lock, and the protective door electric lock corresponds to the protective door (12).
7. The radiopharmaceutical dispensing hot chamber as set forth in claim 1, wherein a lead shielding case (17) is disposed outside the outer case (3), and a plurality of windows corresponding to the protection door (12), the drug inlet drawer (13) and the drug outlet drawer (14) are opened on the lead shielding case (17).
8. The radiopharmaceutical split charging hot chamber according to claim 2, wherein two drawer shells (18) are arranged in the outer box (3), a first opening for the medicine inlet drawer (13) or the medicine outlet drawer (14) to enter and exit is formed in the front side wall of each drawer shell (18), a second opening is formed in the top wall of each drawer shell (18), the second opening is hermetically connected with the medicine inlet inner door (15) or the medicine outlet inner door (16), and air-filled sealing rings (19) are arranged on the medicine inlet drawer (13), the medicine outlet drawer (14), the medicine inlet inner door (15) and the medicine outlet inner door (16).
9. The radiopharmaceutical dispensing hot chamber of claim 8, wherein the drawer housing (18) is connected to the inner container (4) through an air inlet pipe (20), the drawer housing (18) is connected to the air exhaust channel (6) through an air exhaust pipe (21), and valves are arranged on the air inlet pipe (20) and the air exhaust pipe (21).
10. The radiopharmaceutical dispensing hot chamber of claim 8, wherein the medicine inlet inner door (15) and the medicine outlet inner door (16) both comprise a door body and a door frame, the door frame is fixedly connected with the inner container (4), the door frame is hinged with the door body through a hinge, and the door frame is fixedly connected with the inflatable sealing ring (19) corresponding to the door body.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202010025578.8A CN111121188A (en) | 2020-01-10 | 2020-01-10 | Radiopharmaceutical split charging hot chamber |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202010025578.8A CN111121188A (en) | 2020-01-10 | 2020-01-10 | Radiopharmaceutical split charging hot chamber |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN111121188A true CN111121188A (en) | 2020-05-08 |
Family
ID=70487781
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202010025578.8A Pending CN111121188A (en) | 2020-01-10 | 2020-01-10 | Radiopharmaceutical split charging hot chamber |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN111121188A (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN112896892A (en) * | 2021-02-06 | 2021-06-04 | 青岛市中心医院 | Static dispensing warehouse-out channel |
Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103175314A (en) * | 2013-03-20 | 2013-06-26 | 张勇 | Solar vacuum glass heat collecting tube air heat collector |
| CN103230642A (en) * | 2013-05-06 | 2013-08-07 | 余巧生 | Integrated protection method and system for radioactive injection drugs |
| CN203217960U (en) * | 2013-05-06 | 2013-09-25 | 余巧生 | Radionuclide split-charging protective cabinet |
| CN208599333U (en) * | 2018-04-21 | 2019-03-15 | 天津中核永泰科技有限公司 | A kind of air collecting device in Radio-synthesis hot cell |
| CN211695208U (en) * | 2020-01-10 | 2020-10-16 | 华克医疗科技（北京）股份公司 | Air inlet and exhaust system of radioactive drug subpackaging hot chamber |
| CN211695209U (en) * | 2020-01-10 | 2020-10-16 | 华克医疗科技（北京）股份公司 | Radiopharmaceutical split charging hot chamber |
-
2020
- 2020-01-10 CN CN202010025578.8A patent/CN111121188A/en active Pending
Patent Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103175314A (en) * | 2013-03-20 | 2013-06-26 | 张勇 | Solar vacuum glass heat collecting tube air heat collector |
| CN103230642A (en) * | 2013-05-06 | 2013-08-07 | 余巧生 | Integrated protection method and system for radioactive injection drugs |
| CN203217960U (en) * | 2013-05-06 | 2013-09-25 | 余巧生 | Radionuclide split-charging protective cabinet |
| CN208599333U (en) * | 2018-04-21 | 2019-03-15 | 天津中核永泰科技有限公司 | A kind of air collecting device in Radio-synthesis hot cell |
| CN211695208U (en) * | 2020-01-10 | 2020-10-16 | 华克医疗科技（北京）股份公司 | Air inlet and exhaust system of radioactive drug subpackaging hot chamber |
| CN211695209U (en) * | 2020-01-10 | 2020-10-16 | 华克医疗科技（北京）股份公司 | Radiopharmaceutical split charging hot chamber |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN112896892A (en) * | 2021-02-06 | 2021-06-04 | 青岛市中心医院 | Static dispensing warehouse-out channel |
| CN112896892B (en) * | 2021-02-06 | 2022-10-21 | 青岛市中心医院 | Static dispensing warehouse-out channel |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN211695209U (en) | Radiopharmaceutical split charging hot chamber | |
| CN203013280U (en) | Radionuclide packaging protective glove box | |
| CN111121188A (en) | Radiopharmaceutical split charging hot chamber | |
| CN211695208U (en) | Air inlet and exhaust system of radioactive drug subpackaging hot chamber | |
| JP2003310713A (en) | Method for manufacturing tablet by tablet press while protecting circumference and protective device for such tablet press | |
| CN111350381A (en) | Epidemic prevention and control detection and virus preliminary screening cabin | |
| CN109712734A (en) | A kind of rescue personnel lobby having nuclear leakage emergency-sheltering function | |
| CN208271570U (en) | Radioactive isotope purification experiment fence operation case | |
| CN209608184U (en) | A kind of control cabinet | |
| CN111236703A (en) | Full-automatic shielding type mobile medical safety protection device | |
| Bässler et al. | Containment technology | |
| CN212613948U (en) | Novel container formula biological protection transportation unit | |
| EP2515310B1 (en) | Shielded protective tent assembly | |
| CN105604353B (en) | X-ray radiation shields building | |
| RU226765U1 (en) | Negative Pressure Isolator | |
| KR101516011B1 (en) | Box for filtering radiation | |
| CN110164577A (en) | A kind of modularization movable type airborne radioactivity purification device | |
| CN220214338U (en) | Verifiable exhaust device for full-exhaust transmission window | |
| CN218413999U (en) | Be used for long half life nuclide mark protector of low energy | |
| CN111622542A (en) | Isolation system | |
| JPH11311693A (en) | Taking-out method of nuclear reactor pressurized vessel and opening and closing device therefor | |
| CN216189492U (en) | Medicine feeding protection device | |
| CN216596970U (en) | Operating table with alpha, beta and gamma isotope medicament ray multiple protection levels | |
| CN219497352U (en) | Nuclide split charging hot chamber | |
| CN218768768U (en) | Radiation-proof isolator |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination |