CN1111147A

CN1111147A - Blood-enriching capsule and its preparation

Info

Publication number: CN1111147A
Application number: CN 94117346
Authority: CN
Inventors: 谭世平; 杨业清; 周克元; 方富永
Original assignee: Individual
Current assignee: Individual
Priority date: 1994-10-20
Filing date: 1994-10-20
Publication date: 1995-11-08

Abstract

The blood-enriching capsule consists of dry heme paste, Polygonum multiflorum, Lycium chinense, Chinese date and cane sugar. The present invention features that fresh pig blood is passed through four-time centrifugal separation with the third and the fourth separation liquid being produced into dry heme paste, which is then mixed with other material, decocted, stoved, crushed into fine powder, mixed with dextrin and capsulized. As an iron-enriching prepn, the blood-enriching capsule has high effect.

Description

Blood-enriching capsule and its preparation

The invention belongs to a kind of blood-enriching capsule and manufacture method thereof.

At present, the patient who causes anemia because of iron deficiency is a lot of, child particularly, to Patients with iron deficiency anemia, generally all be to use ferrous sulfate and derivative formulations thereof as medicine, the preparation method of patent 89105151.1 children's antanemic syrups for example, iron dust nonheme iron in this class preparation, not only absorbance is low, and digestive tract is had stronger stimulation, can cause stomachache, side effect such as diarrhoea, taking dose will just can reach curative effect very greatly, has increased side effect so again, patient is difficult to adhere to taking, and has influenced curative effect.

The purpose of this invention is to provide a kind of is the blood-enriching capsule and preparation method thereof of raw material with the fresh porcine blood, treatment iron deficiency anemia instant effect.

The present invention is made up of the dried cream of haemachrome, Radix Polygoni Multiflori, Fructus Lycii, Fructus Jujubae, and its production stage is:

(1) earlier with the fresh porcine blood centrifugalize, discard blood plasma, with the visible component fragmentation, boil, add ethanol, stirring again, carry out centrifugalize again, from liquid, reclaim ethanol, visible component is added water stir, the debugging pH value, restir, neutralization, carry out centrifugalize for the third time then, liquid collecting is got up to prepare use liquid A, visible component is extracted once again, carry out the 4th centrifugalize, visible component is extracted once again, carries out the 4th centrifugalize, and visible component discards, to make liquid B mixes with standby liquid A, drying makes the dried cream of haemachrome, and it is standby to be ground into fine powder;

(2) get each 50～150 gram of Radix Polygoni Multiflori, Fructus Lycii, Fructus Jujubae and decoct with water secondary, each 1.8～2.2 hours, collecting decoction, filtration, filtrate were concentrated in right amount, made concentrated filtrate C;

(3) add among the concentrated filtrate C that step (2) is made 50～150 gram dried cream fine powder, mixings, dry, be ground into fine powder, adding dextrin amount to every capsules total capacity is 0.3g, is distributed into 400 of capsules promptly.

The present invention compares with common ferrous sulfate and derivative formulations thereof, and as treatment iron deficiency anemia medicine instant effect, without any side effects, taking convenience is a kind of ideal iron supplement agent.

Embodiment 1: in step (2), the raw material Sanguis sus domestica must be fresh, through four centrifugalize, discard blood plasma during centrifugalize for the first time, must add adequate amount of ethanol during centrifugalize for the second time, ethanol is reclaimed in centrifugal back from liquid, ethanol is reusable, the debugging pH value is in adding according to pH value and material, during centrifugalize for the third time, the gained liquid A will be stayed standby, visible component is carried out the 4th centrifugalize again, make liquid B and mix drying with standby liquid A, make the dried cream of haemachrome, it is standby to be ground into fine powder; In step (2), get each 100 gram of Radix Polygoni Multiflori, Fructus Lycii, Fructus Jujubae and decoct with water 2 times, each 2 hours, collecting decoction filtered, and filtrate is condensed into liquid C; Add the dried cream fine powder of 100 gram haemachrome in step (3), mixing, oven dry are ground into fine powder, and it is an amount of to add dextrin, are distributed into 400 of 0.3g capsules promptly.

Embodiment 2: method is with embodiment 1, but in step (2), gets Radix Polygoni Multiflori 50 grams, Fructus Lycii 50 grams, Fructus Jujubae 50 grams and adds water, decocts secondary, each 1.8 hours; In step (3), add the dried cream fine powder of 150 gram haemachrome.

Embodiment 3: method is with embodiment 1, but in step (2), gets Radix Polygoni Multiflori 150 grams, Fructus Lycii 150 grams, and Fructus Jujubae 150 grams decoct with water each 2.2 hours 2 times; In step (3), add the dried cream fine powder of 80 gram haemachrome.

Blood-enriching capsule of the present invention is through 230 routine Patients with iron deficiency anemia clinical verifications, and total effective rate reaches 96%, welcome by the patient.

Claims

1, a kind of blood-enriching capsule and manufacture method thereof, by the dried cream of haemachrome, Radix Polygoni Multiflori, Fructus Lycii, Fructus Jujubae, sucrose is formed, be characterised in that its production stage is: (1) discards blood plasma, with the visible component fragmentation earlier with the fresh porcine blood centrifugalize, boil, add ethanol again, stir, carry out centrifugalize again, from liquid, reclaim ethanol, visible component is added water stir the adjustment pH value, restir, neutralization, carry out centrifugalize for the third time then, liquid collecting is got up to prepare use liquid A, visible component is extracted once again, carry out the 4th centrifugalize, visible component discards, and will make liquid B and mix drying with standby liquid A, make the dried cream of haemachrome, it is standby to be ground into fine powder; (2) get each 50～150 gram of Radix Polygoni Multiflori, Fructus Lycii, Fructus Jujubae and decoct with water secondary, each 1.8～2.2 hours, collecting decoction, filtration, filtrate were concentrated in right amount, made concentrated filtrate C; (3) add among the concentrated filtrate C that step (2) is made 50～150 gram haemachrome dried cream fine powders, mixing, dry, be ground into fine powder, adding dextrin amount to every capsules total capacity is 0.3g, is distributed into capsule promptly;

2,, it is characterized in that described Radix Polygoni Multiflori, Fructus Lycii, Fructus Jujubae amount are 90～110 grams, decoct with water each 2 hours 2 times according to the described method of claim 1;

3,, it is characterized in that being incorporated as in the described step (3) the dried cream fine powder of 90～110 gram haemachrome according to the described method of claim 1.