CN111109283B - Long-acting antibacterial mildew inhibitor, preparation method thereof and application thereof in space station environment - Google Patents
Long-acting antibacterial mildew inhibitor, preparation method thereof and application thereof in space station environment Download PDFInfo
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Abstract
The invention relates to the technical field of antibacterial mildew inhibitors, and provides a long-acting antibacterial mildew inhibitor, a preparation method thereof and application thereof in a space station environment. The long-acting antibacterial mildew inhibitor provided by the invention takes the organosilicon quaternary ammonium salt as a main sterilization component, can inhibit bacteria, yeasts and fungi for a long time, and has high safety and no potential hazards of acute toxicity and accumulated toxicity; the antibacterial mildew preventive has long-acting antibacterial mildew preventive performance, and bacterial mildew is not easy to generate drug resistance; the product has no hidden color change trouble and toxic components, and can be stored for a long time; furthermore, propylene glycol and the like are used as stabilizing agents, so that the release amount of voc can be reduced, and the influence on the health of astronauts caused by volatilization of toxic gases such as methanol in special environments of space stations can be avoided. The long-acting antibacterial mildew inhibitor provided by the invention can meet the long-acting antibacterial mildew-proof requirements of aluminum alloy and textiles in the cabin of the space station, and meanwhile, the release amount of the product voc is low, so that the air quality requirement of the space station is met.
Description
Technical Field
The invention relates to the technical field of antibacterial mildewcide, and particularly relates to a long-acting antibacterial mildewcide, a preparation method thereof and application thereof in a space station environment.
Background
Space station microbes can affect the health of astronauts and the safety of the environment in the cabin. Research has proved that the growth speed of the space station microorganism is obviously faster than that of the ground control group. The researchers found 84 microorganisms in the international space station cabin, and identified 18 kinds of bacteria and 12 kinds of fungi, wherein 49 kinds of bacteria and 35 kinds of fungi. Microorganisms are present in the air, water and object surfaces of the flat space station. In the international space station, fungi mainly belonging to the genus Penicillium, Aspergillus and Cladosporium adhere to the surface of a material, and all of the fungi tend to corrode the material. The bacteria are mainly staphylococcus, corynebacterium, bacillus and micrococcus. The microorganisms mainly exist in areas with poor ventilation and equipment and on low-temperature surfaces which are easy to condense condensed water, such as ventilation pipelines of cabins, inlets of cooling fans and the like, and cause hidden dangers for safe operation of the equipment, such as insulation reduction, poor electric contact, sealing failure and other adverse consequences caused by corrosion of electronic components due to mass propagation of mold in international space stations. In 2001, in the Russian cabin of the International space station, smoke sensor failure due to mold corrosion also occurred. Microorganisms can also gather in places where human skin and hands are frequently contacted, such as handles and side plates which are frequently touched by astronauts in personal cleaning areas of international space stations, and a large amount of mold bacterial plaques are bred. Although the microorganisms are a part of the ecosystem, in the special environment of the space station, excessive microorganisms can cause allergic reaction of astronauts and affect the quality of air in the cabin. The prevention and control of microorganisms in space stations is therefore an important aspect of the environmental control of spacecraft.
At present, the surfaces of materials in cabins are treated by an antibacterial method in the final assembly stage and after launching of international space stations, and the total number of microorganisms is controlled. If the plant is a biological purification plant, the environmental microorganisms are monitored regularly; before an operator enters a workshop, replacing sterilized clothes and sterilizing hands by alcohol; after the final assembly is finished, disinfecting the surface of the closed cabin by using hydrogen peroxide, and purifying gas to replace gas in the cabin; the post-launch space station performs vacuum cleaning weekly. However, the method can not sterilize all parts and surfaces in the cabin, and the condition of microorganism breeding still occurs in dead corners and equipment. The invention relates to a preparation method of a long-acting antibacterial solid slide film layer containing silver ions, which is applied for the antibacterial technology of a space station in China, for example, 201811493172.1. However, silver ions have limited antibacterial time, are easy to discolor after being used on textiles, and have no universality in the antibacterial application of various materials in a space station. More importantly, the accumulated toxicity of the silver nano-ions in the human body is paid more and more attention, so that the great adoption of silver ion antibacterial products in space stations may cause hidden troubles to the health of astronauts.
In summary, the excessive propagation of space microorganisms is a potential safety hazard threatening the health of spacemen in the cabin and the normal operation of components, and the conventional method cannot achieve the purpose of effectively controlling the propagation of microorganisms for a long time. Therefore, it is necessary to develop a safe, broad-spectrum, long-acting antibacterial and mildewproof product, which provides a reliable product for the prevention and control of microorganisms in space stations.
Disclosure of Invention
In view of the above, the present invention aims to provide a long-acting antibacterial mildew inhibitor, a preparation method thereof and an application thereof in a space station environment. The long-acting antibacterial mildew inhibitor provided by the invention has high safety, no acute toxicity and accumulated toxicity hidden danger, long-acting antibacterial mildew resistance, difficulty in generation of drug resistance of bacterial mildew, no color change hidden danger, no toxic component and suitability for various materials in a cabin of a space station.
In order to achieve the above object, the present invention provides the following technical solutions:
the long-acting antibacterial mildew inhibitor comprises the following components in percentage by mass: 0.2-5% of organosilicon quaternary ammonium salt, 0.5-5% of stabilizer, 0.1-3% of synergist, 0.1-2% of film-forming agent and the balance of water.
Preferably, the organosilicon quaternary ammonium salt comprises one or more of trimethoxy silane quaternary ammonium salt, triethoxy silane quaternary ammonium salt and diethoxy methyl silane quaternary ammonium salt.
Preferably, the stabilizer comprises one or more of propylene glycol, glycerol, butanediol, pentanediol, polyethylene glycol, ethylene diamine tetraacetic acid, sodium ethylene diamine tetracetate, hydroxyethyl ethylene diamine triacetate and hydrogen peroxide.
Preferably, the synergist is one or more of isothiazolinone, dopamine hydrochloride, benzylalkane ammonia chloride, polyhexamethylene guanidine, chitosan and betaine.
Preferably, the film forming agent is one or more of an acrylate film forming agent, a cellulose film forming agent, gelatin, poloxamer, a carbomer organic silicon resin polymer and polyvinylpyrrolidone.
The invention provides a preparation method of the long-acting antibacterial mildew preventive in the scheme, which comprises the following steps:
mixing the organosilicon quaternary ammonium salt, the stabilizer, the synergist, the film-forming agent and water to obtain the long-acting antibacterial mildew preventive.
Preferably, the temperature of the mixing is room temperature.
The invention provides application of the long-acting antibacterial mildew preventive in the space station environment.
The invention provides a long-acting antibacterial mildew inhibitor which comprises the following components in percentage by mass: 0.2-5% of organosilicon quaternary ammonium salt, 0.5-5% of stabilizer, 0.1-3% of synergist, 0.1-2% of film-forming agent and the balance of water. The long-acting antibacterial mildew inhibitor provided by the invention takes the organosilicon quaternary ammonium salt as a main sterilization component, can inhibit bacteria, yeasts and fungi for a long time, and has high safety and no potential hazards of acute toxicity and accumulated toxicity; the antibacterial mildew preventive provided by the invention has long-acting antibacterial mildew preventive performance, and the bacterial mildew is not easy to generate drug resistance; has no hidden color change trouble and no toxic component, and can be stored for a long time.
The invention also provides application of the long-acting antibacterial mildew preventive in the space station environment. The long-acting antibacterial mildew inhibitor provided by the invention does not contain toxic organic solvents, is convenient to coat, can be used by various materials, has a long-acting antibacterial mildew-proof function, can meet the long-acting antibacterial mildew-proof requirements of aluminum alloy and textiles in a cabin of a space station, has a low voc release amount, meets the air quality requirements of the space station, and does not influence the health of astronauts.
Drawings
FIG. 1 is the results of the textile surface mildew resistance test in example 1;
FIG. 2 shows the results of the surface mildew resistance test for the aluminum alloy of example 2;
FIG. 3 shows the results of the plate mildew resistance test in example 4.
Detailed Description
The invention provides a long-acting antibacterial mildew inhibitor which comprises the following components in percentage by mass: 0.2-5% of organosilicon quaternary ammonium salt, 0.5-5% of stabilizer, 0.1-3% of synergist, 0.1-2% of film-forming agent and the balance of water, wherein the preferable components comprise the following components in percentage by mass: 0.5-4% of organosilicon quaternary ammonium salt, 1-3.5% of stabilizer, 0.5-2% of synergist, 0.5-1.5% of film-forming agent and the balance of water.
In the invention, the organosilicon quaternary ammonium salt preferably comprises one or more of trimethoxy silane quaternary ammonium salt, triethoxy silane quaternary ammonium salt and diethoxy methyl silane quaternary ammonium salt; the trimethoxy silane quaternary ammonium salt is preferably (trimethoxy silicon) propyl-N-octadecyl dimethyl ammonium chloride; the triethoxysilicane quaternary ammonium salt is preferably (triethoxysilyl) propyl-N-octadecyl dimethyl ammonium chloride; the diethoxymethylsilane quaternary ammonium salt is preferably (diethoxysilyl) propyl-N-octadecyl dimethyl ammonium chloride and/or (diethoxysilyl) propyl-N-hexadecyl dimethyl ammonium chloride.
The antibacterial mildew inhibitor is prepared by taking the organic silicon quaternary ammonium salt as a main sterilization component, and the organic silicon quaternary ammonium salt is an environmentally-safe cationic surfactant, has a good sterilization effect, and can inhibit bacteria, yeasts and fungi for a long time. The organosilicon quaternary ammonium salt sterilization principle is that organosilicon is used as a medium, quaternary ammonium salt molecules with positive charges can be adsorbed on the surfaces of bacteria with negative charges through static electricity, cell membranes are penetrated, the permeability of bacterial cell walls is changed, and the bacteria are inactivated and killed in a contact mode, so that the sterilization mode has the following advantages: 1. physical sterilization is adopted, and the phenomenon of drug resistance is not easy to occur; 2. after the silicon-oxygen radical in the organic silicon quaternary ammonium salt structure is hydrolyzed, the silicon-oxygen radical and the hydroxyl radical on the surface of the fabric or the material are subjected to cross-linking reaction, namely, the silicon-oxygen radical is connected and woven on the surface of the textile or the metal material, so that the functions of water washing resistance and long-acting antibiosis are realized; 3. the organosilicon quaternary ammonium salt belongs to a non-dissolution type antibacterial agent, and compared with dissolution type antibacterial agents such as short-chain and double-chain quaternary ammonium salts, the organosilicon quaternary ammonium salt has low toxicity and irritation to a human body and is not easy to be enriched on the surface of the human body; 4. the organosilicon quaternary ammonium salt antibacterial agent liquid is convenient to use, does not need a special process, is directly wiped on the surface of a material, and is dried or baked at room temperature. In addition, the organosilicon quaternary ammonium salt has higher safety, and toxicity tests such as skin irritation, oral acute toxicity, mutability, teratogenicity and the like of the organosilicon quaternary ammonium salt pass the tests of the United states environmental protection agency.
In the present invention, the stabilizer preferably includes one or more of propylene glycol, glycerin, butylene glycol, pentylene glycol, polyethylene glycol, ethylene diamine tetraacetic acid, sodium ethylene diamine tetracetate, hydroxyethylethylene diamine triacetate, and hydrogen peroxide. The stability of the organic silicon quaternary ammonium salt is improved by adding the stabilizer, and the failure caused by cross-linking precipitation of the organic silicon quaternary ammonium salt is avoided, so that the antibacterial mildew preventive can be stored for a long time.
In the invention, the synergist is preferably one or more of isothiazolinone, dopamine hydrochloride, benzylalkane ammonia chloride, polyhexamethylene guanidine, chitosan and betaine. In the invention, the synergist can synergistically enhance the antibacterial and mildewproof effects.
In the invention, the film forming agent is preferably one or more of an acrylate film forming agent, a cellulose film forming agent, gelatin, poloxamer, a carbomer organic silicon resin polymer and polyvinylpyrrolidone; the poloxamer is preferably poloxamer 407; the carbomer is preferably carbomer 940; the polyvinylpyrrolidone is preferably polyvinylpyrrolidone K30.
The invention provides a preparation method of the long-acting antibacterial mildew preventive in the scheme, which comprises the following steps:
Mixing the organosilicon quaternary ammonium salt, the stabilizer, the synergist, the film-forming agent and water to obtain the long-acting antibacterial mildew preventive.
In a specific embodiment of the present invention, a commercially available silicone quaternary salt solution is preferably used as a raw material to prepare the antibacterial and antifungal agent of the present invention, when a commercially available silicone quaternary salt solution is used as a raw material, a silicone quaternary salt solution with propylene glycol as a solvent is preferably selected, and the mass concentration of the silicone quaternary salt solution is preferably 10 to 60%, and more preferably 50%.
The organic silicon quaternary ammonium salt solution with propylene glycol as solvent is selected as the raw material, so that other components can be prevented from being introduced into the antibacterial mildew preventive, the volatilization of toxic gases such as methanol and the like can be avoided on the basis of keeping the antibacterial activity of the organic silicon quaternary ammonium salt, the voc release amount of the antibacterial mildew preventive is reduced, and the influence on the health of astronauts is avoided.
In the present invention, the temperature of the mixing is preferably room temperature; the mixing is preferably stirring mixing, and the stirring mixing time is preferably 10 min. In the present invention, after the above components are mixed, the pH of the obtained mixed solution is within a range of 8 to 10, and in a specific embodiment of the present invention, if the pH of the mixed solution is not within a range of 8 to 10, the pH of the antimicrobial and antifungal agent is preferably adjusted to 8 to 10 using a sodium hydroxide solution having a mass concentration of 1%.
The invention provides application of the long-acting antibacterial mildew preventive in the space station environment. The application method of the long-acting antibacterial mildew preventive in the space station environment has no special requirements, and the long-acting antibacterial mildew preventive can be directly wiped or sprayed on the surface of a substrate. The long-acting antibacterial mildew inhibitor provided by the invention is high in safety, does not contain toxic organic solvents, is convenient to coat, has a long-acting antibacterial mildew-proof function, can meet the long-acting antibacterial mildew-proof requirement of aluminum alloy and textiles in a cabin of a space station, and simultaneously releases voc to meet the air quality requirement of the space station without influencing the health of astronauts.
The embodiments of the present invention will be described in detail with reference to the following examples, but they should not be construed as limiting the scope of the present invention.
Example 1
The antibacterial and antifungal agent of example 1 was prepared from an organosilicon quaternary ammonium salt solution (solvent propylene glycol, solute (trimethoxysilyl) propyl-N-octadecyl dimethyl ammonium chloride, mass concentration 50%) as a raw material, the organosilicon quaternary ammonium salt solution, chitosan, dopamine hydrochloride, poloxamer and water were mixed, stirred for 10 minutes, the pH was adjusted to 8.5 using 0.1% sodium hydroxide solution, and filled.
The obtained product contains per 100 g: 0.5g of organosilicon quaternary ammonium salt, 0.5g of propylene glycol, 1.0g of chitosan, 0.2g of dopamine hydrochloride, 4071.2g of poloxamer and the balance of water.
And (3) stability testing: the test temperature is 25 ℃, the medicine stability experiment box is placed, and the result shows that the product can be stably stored for more than 2 years at room temperature.
And (3) performing mildew resistance test on the surface of the textile, wherein Aspergillus niger which is the most common fungus in a space station is used as a test strain:
preparing bacterial liquid:
diluting Aspergillus niger to 10 deg.C in propagation stage with sterilized deionized water5CFU。
The aramid fiber (4cm multiplied by 4cm) of the textile commonly used in the space station is sterilized under high pressure, 10 mu L of Aspergillus niger liquid is dripped on the surface of the aramid fiber, the aramid fiber is placed in a culture dish with a cover and is cultured in a mould incubator for 7 to 10 days until the mould bacterial plaque can be directly observed.
And (3) sticking the bacterial plaque on the surface of the textile by using an adhesive tape, then dropwise adding 1mL of the antibacterial mildew preventive prepared in the example 1 to fully wet the aramid fabric, and then drying the aramid fabric at room temperature for 8 hours until the fabric is completely dried. The control group repeats the operation, and the antibacterial and mildewproof agent is replaced by the same amount of deionized water.
The dried pieces were placed in petri dishes with lids and incubated in a mold incubator for 7 days.
As shown in FIG. 1, (a) is a control group and (b) is an antibacterial and antifungal agent-treated group; as can be seen from fig. 1, the aramid cloth pieces coated with the antibacterial and antifungal agents have no obvious bacterial plaque, and a large amount of bacterial plaque is generated on the control group, which shows that the antibacterial and antifungal agents of the present invention have excellent long-term antibacterial property.
Example 2
The antibacterial and antifungal agent of example 2 is prepared by using an organosilicon quaternary ammonium salt solution (the solvent is propylene glycol, the solute is (triethoxysilyl) propyl-N-octadecyl dimethyl ammonium chloride, and the mass concentration is 60%) as a raw material, mixing the organosilicon quaternary ammonium salt solution, pentanediol, chitosan, dopamine hydrochloride, polyvinylpyrrolidone K30 and water, stirring for 10 minutes, and filling.
The obtained product contains per 100 g: 0.2g of organosilicon quaternary ammonium salt, 0.13g of propylene glycol, 0.8g of pentanediol, 1.0g of chitosan, 0.1g of dopamine hydrochloride, K300.5g of polyvinylpyrrolidone and the balance of water.
The stability test was performed according to the method of example 1, and the results showed that the product was stable for more than 1 year at room temperature.
And (3) performing mildew resistance test on the surface of the aluminum alloy, wherein the most common fungus Aspergillus niger in a space station is used as a test strain:
Preparing bacterial liquid: diluting Aspergillus niger to 10 deg.C in propagation stage with sterilized deionized water5CFU。
The aluminum alloy (4cm multiplied by 4cm) is usually used for cleaning and wiping the surface of the space station by adopting absolute ethyl alcohol, and the space station is sterilized at high temperature for later use.
And dripping 10 mu L of Aspergillus niger liquid on the surface of the aluminum alloy, dripping 0.5mL of the antibacterial and mildewproof agent prepared in the example 2, uniformly coating the surface of the aluminum alloy, placing the aluminum alloy in a culture dish with a cover, culturing in a mildew incubator for 28 days, and observing. The control group repeats the operation, and the antibacterial and mildewproof agent is replaced by the same amount of deionized water.
The observation results are shown in fig. 2, in which (a) is a control group and (b) is an antibacterial and antifungal agent-treated group in fig. 2; as can be seen from FIG. 2, a large amount of mold plaque was formed on the control group, and the plaque coated with the antibacterial and antifungal agent was significantly less than that of the control group, indicating that the antibacterial and antifungal agent of the present invention has excellent long-lasting antibacterial activity.
Example 3
The antibacterial and antifungal agent of example 3 was prepared from a silicone quaternary ammonium salt solution (solvent propylene glycol, solute (diethoxysilyl) propyl-N-hexadecyldimethylammonium chloride, mass concentration 50%) as a raw material, and the silicone quaternary ammonium salt solution, glycerol, betaine, carbomer 940 and water were mixed, stirred for 10 minutes, and filled.
The obtained product contains per 100 g: 1.0g of organosilicon quaternary ammonium salt, 1.0g of propylene glycol, 2.4g of glycerol, 1.2g of betaine, 9400.8g of carbomer and the balance of water.
The stability test was performed according to the method of example 1, and the results showed that the product was stable for more than 2 years at room temperature.
Plate antibacterial test:
preparing bacterial liquid: respectively diluting staphylococcus aureus and escherichia coli to 10 degrees by using sterilized deionized water4、103CFU。
And (3) preparing a TSA flat plate, dripping 100 mu L of staphylococcus aureus and escherichia coli on the flat plate, drying in an ultra-clean bench, dripping 0.5mL of the antibacterial and antifungal agent prepared in the embodiment 3, uniformly coating the surface of the flat plate, culturing in a bacterial incubator for 2 days, and observing. The control group repeats the operation, and the antibacterial and mildewproof agent is replaced by the same amount of deionized water.
The observations are shown in table 1:
TABLE 1 antibacterial and antifungal Agents against Staphylococcus aureus and Escherichia coli
As can be seen from the results in Table 1, a large number of colonies of Staphylococcus aureus and Escherichia coli were formed in the control group, and the number of colonies in the antimicrobial-coated group was significantly smaller than that in the control group.
Example 4
The antibacterial and antifungal agent of example 4 is prepared from a silicone quaternary ammonium salt solution (30% by mass with a solvent of propylene glycol and a solute of (diethoxysilyl) propyl-N-octadecyl dimethyl ammonium chloride), and the silicone quaternary ammonium salt solution, polyethylene glycol, chitosan, sodium carboxymethylcellulose and water are mixed, stirred for 10 minutes and filled.
The obtained product contains per 100 g: 1.0g of organosilicon quaternary ammonium salt, 2.3g of propylene glycol, 0.8g of polyethylene glycol, 0.8g of chitosan, 1.2g of sodium carboxymethylcellulose and the balance of water.
The stability test was performed according to the method of example 1, and the results showed that the product was stable for more than 2 years at room temperature.
Plate mildew resistance test:
preparing bacterial liquid: diluting Aspergillus niger to 10 deg.C in propagation stage with sterilized deionized water5CFU。
Preparing a PDA flat plate, dripping 100 mu L of Aspergillus niger liquid into the flat plate, drying in an ultra-clean bench, dripping 0.5mL of antibacterial and mildewproof agent, uniformly coating the surface of the flat plate, culturing in a bacterial incubator for 2 days, and observing. The control group repeats the operation, and the antibacterial and mildewproof agent is replaced by the same amount of deionized water.
The observation results are shown in fig. 3, in which (a) in fig. 3 is a control group and (b) is an antibacterial and antifungal agent-treated group; as can be seen from FIG. 3, a large number of Aspergillus niger colonies were formed in the control group, and the number of colonies coated with the antibacterial and antifungal agent was significantly less than that in the control group.
Carrying out a textile surface mildew-proof test on the antibacterial mildew-proof agents of the embodiments 2-4 according to the method of the embodiment 1, wherein the test result is similar to that of the embodiment 1; the antibacterial and mildewproof agents of the examples 1, 3 and 4 are subjected to an aluminum alloy surface mildewproof test according to the method of the example 2, and the test result is similar to that of the example 2; the antibacterial and antifungal agents of examples 1 to 2 and 4 were subjected to the plate antibacterial test in the same manner as in example 3, and the test results were similar to those in example 3, and the antibacterial and antifungal agents of examples 1 to 3 were subjected to the plate antibacterial test in the same manner as in example 4, and the test results were similar to those in example 4.
Testing the voc content:
the voc total amount of the antibacterial and antifungal agent prepared in example 1 was measured by GC method, and the specific test results are shown in table 2.
TABLE 2 test results of the total amount of the antibacterial and antifungal agents voc
| Sample name | Detecting items | The result of the detection | Unit of | Detection method |
| Antibacterial mildew preventive | Total amount of voc | 33.26 | μg/L | GC |
The same test was performed on the total amount of voc of the antibacterial mildewcide prepared in examples 2 to 4, and the results showed that the total amount of voc of the antibacterial mildewcide was all low.
From the results of the above examples, it is clear that the antibacterial mildew preventive provided by the present invention has long-lasting antibacterial mildew resistance, high safety, low voc emission, good stability, and is suitable for antibacterial mildew prevention of materials such as aramid fibers and aluminum alloys commonly used in space stations.
The foregoing is only a preferred embodiment of the present invention, and it should be noted that, for those skilled in the art, various modifications and decorations can be made without departing from the principle of the present invention, and these modifications and decorations should also be regarded as the protection scope of the present invention.
Claims (4)
1. The long-acting antibacterial mildew inhibitor is characterized by comprising the following components in percentage by mass: 0.2-5% of organosilicon quaternary ammonium salt, 0.5-5% of stabilizer, 0.1-3% of synergist, 0.1-2% of film-forming agent and the balance of water; the stabilizer is one or more of propylene glycol, glycerol, butanediol, pentanediol, polyethylene glycol, ethylene diamine tetraacetic acid, sodium ethylene diamine tetracetate and hydroxyethyl ethylene diamine triacetate; the synergist is one or more of isothiazolinone, dopamine hydrochloride, benzylalkonium chloride, chitosan and betaine; the film forming agent is one or more of an acrylate film forming agent, a cellulose film forming agent, gelatin, poloxamer, a carbomer organic silicon resin polymer and polyvinylpyrrolidone; the organosilicon quaternary ammonium salt is one or more of trimethoxy silane quaternary ammonium salt, triethoxy silane quaternary ammonium salt and diethoxymethyl silane quaternary ammonium salt.
2. A method for preparing the long-acting antibacterial mildewcide according to claim 1, which is characterized by comprising the steps of:
mixing the organosilicon quaternary ammonium salt, the stabilizer, the synergist, the film-forming agent and water to obtain the long-acting antibacterial mildew preventive.
3. The method of claim 2, wherein the temperature of the mixing is room temperature.
4. The use of a long-acting antimicrobial mildewcide according to claim 1 in a space station environment.
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| CN111558328B (en) * | 2020-05-25 | 2023-09-01 | 雅思汀娜（北京）科技有限公司 | Lignin cationic surfactant and preparation method thereof, and long-acting antibacterial agent and preparation method thereof |
| CN112143275A (en) * | 2020-08-25 | 2020-12-29 | 任轶 | Formula and using method of sterilization bacteriostat |
| CN112335687A (en) * | 2020-10-22 | 2021-02-09 | 广东京兴航天农业技术开发有限公司 | Long-acting antibacterial disinfectant |
| CN113615711B (en) * | 2021-06-19 | 2023-01-10 | 武汉京创崇高生物技术有限公司 | Long-acting microorganism protection composition and preparation method thereof |
| CN114032681B (en) * | 2021-11-26 | 2023-10-13 | 广东省科学院化工研究所 | Sterilization mildew inhibitor and preparation method and application thereof |
| CN114438821A (en) * | 2021-12-30 | 2022-05-06 | 四川大学 | Preparation method of antibacterial and mildewproof aramid paper or cloth |
| CN114503981A (en) * | 2022-01-07 | 2022-05-17 | 上海膜益信息科技有限公司 | Non-layering mildew preventive and preparation method and application thereof |
| CN115595034B (en) * | 2022-10-25 | 2023-08-08 | 广东润和新材料科技有限公司 | Antiviral and antibacterial nano paint for engine room as well as preparation method and application thereof |
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