CN111097065B - Carbon fiber-based porous material, preparation method and application thereof - Google Patents
Carbon fiber-based porous material, preparation method and application thereof Download PDFInfo
- Publication number
- CN111097065B CN111097065B CN201911386806.8A CN201911386806A CN111097065B CN 111097065 B CN111097065 B CN 111097065B CN 201911386806 A CN201911386806 A CN 201911386806A CN 111097065 B CN111097065 B CN 111097065B
- Authority
- CN
- China
- Prior art keywords
- carbon fiber
- based porous
- porous material
- carbon
- preparation
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
- VNWKTOKETHGBQD-UHFFFAOYSA-N methane Chemical compound C VNWKTOKETHGBQD-UHFFFAOYSA-N 0.000 title claims abstract description 111
- 229920000049 Carbon (fiber) Polymers 0.000 title claims abstract description 109
- 239000004917 carbon fiber Substances 0.000 title claims abstract description 109
- 239000011148 porous material Substances 0.000 title claims abstract description 78
- 238000002360 preparation method Methods 0.000 title claims abstract description 37
- 238000000034 method Methods 0.000 claims abstract description 34
- 206010052428 Wound Diseases 0.000 claims abstract description 29
- 208000027418 Wounds and injury Diseases 0.000 claims abstract description 29
- 230000015271 coagulation Effects 0.000 claims abstract description 24
- 238000005345 coagulation Methods 0.000 claims abstract description 24
- 239000003575 carbonaceous material Substances 0.000 claims abstract description 20
- 229920001661 Chitosan Polymers 0.000 claims abstract description 18
- 238000010257 thawing Methods 0.000 claims abstract description 16
- 239000000853 adhesive Substances 0.000 claims abstract description 11
- 230000001070 adhesive effect Effects 0.000 claims abstract description 11
- 230000023555 blood coagulation Effects 0.000 claims abstract description 11
- 238000004108 freeze drying Methods 0.000 claims abstract description 9
- 238000002156 mixing Methods 0.000 claims abstract description 7
- 229920002101 Chitin Polymers 0.000 claims abstract description 4
- 239000000463 material Substances 0.000 claims description 20
- 238000003756 stirring Methods 0.000 claims description 13
- 238000001035 drying Methods 0.000 claims description 11
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 claims description 10
- 229910021393 carbon nanotube Inorganic materials 0.000 claims description 8
- 239000002041 carbon nanotube Substances 0.000 claims description 8
- 238000007710 freezing Methods 0.000 claims description 8
- 230000008014 freezing Effects 0.000 claims description 8
- 239000002270 dispersing agent Substances 0.000 claims description 7
- 238000001816 cooling Methods 0.000 claims description 6
- 230000001737 promoting effect Effects 0.000 claims description 6
- 239000004372 Polyvinyl alcohol Substances 0.000 claims description 5
- 229920002125 Sokalan® Polymers 0.000 claims description 5
- 239000004584 polyacrylic acid Substances 0.000 claims description 5
- 229920002451 polyvinyl alcohol Polymers 0.000 claims description 5
- 229920002472 Starch Polymers 0.000 claims description 4
- GVGUFUZHNYFZLC-UHFFFAOYSA-N dodecyl benzenesulfonate;sodium Chemical compound [Na].CCCCCCCCCCCCOS(=O)(=O)C1=CC=CC=C1 GVGUFUZHNYFZLC-UHFFFAOYSA-N 0.000 claims description 4
- 229940080264 sodium dodecylbenzenesulfonate Drugs 0.000 claims description 4
- 239000008107 starch Substances 0.000 claims description 4
- 235000019698 starch Nutrition 0.000 claims description 4
- 229920002134 Carboxymethyl cellulose Polymers 0.000 claims description 3
- 229920001353 Dextrin Polymers 0.000 claims description 3
- 239000004375 Dextrin Substances 0.000 claims description 3
- DBMJMQXJHONAFJ-UHFFFAOYSA-M Sodium laurylsulphate Chemical compound [Na+].CCCCCCCCCCCCOS([O-])(=O)=O DBMJMQXJHONAFJ-UHFFFAOYSA-M 0.000 claims description 3
- 239000011230 binding agent Substances 0.000 claims description 3
- 239000001768 carboxy methyl cellulose Substances 0.000 claims description 3
- 235000010948 carboxy methyl cellulose Nutrition 0.000 claims description 3
- 239000008112 carboxymethyl-cellulose Substances 0.000 claims description 3
- 235000019425 dextrin Nutrition 0.000 claims description 3
- 239000002134 carbon nanofiber Substances 0.000 claims description 2
- 229910021389 graphene Inorganic materials 0.000 claims description 2
- 235000019422 polyvinyl alcohol Nutrition 0.000 claims description 2
- 229910052708 sodium Inorganic materials 0.000 claims description 2
- 239000011734 sodium Substances 0.000 claims description 2
- 238000004519 manufacturing process Methods 0.000 claims 3
- QAOWNCQODCNURD-UHFFFAOYSA-L Sulfate Chemical compound [O-]S([O-])(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-L 0.000 claims 2
- 230000029663 wound healing Effects 0.000 claims 2
- QGZKDVFQNNGYKY-UHFFFAOYSA-O Ammonium Chemical compound [NH4+] QGZKDVFQNNGYKY-UHFFFAOYSA-O 0.000 claims 1
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 claims 1
- 239000012782 phase change material Substances 0.000 abstract description 50
- 239000002131 composite material Substances 0.000 abstract description 44
- 239000011162 core material Substances 0.000 abstract description 21
- 230000008859 change Effects 0.000 abstract description 17
- 230000035876 healing Effects 0.000 abstract description 9
- 210000004369 blood Anatomy 0.000 abstract description 5
- 239000008280 blood Substances 0.000 abstract description 5
- 239000003805 procoagulant Substances 0.000 abstract description 3
- 239000012467 final product Substances 0.000 abstract description 2
- 239000000243 solution Substances 0.000 description 19
- 239000012071 phase Substances 0.000 description 12
- 239000002202 Polyethylene glycol Substances 0.000 description 10
- 229920001223 polyethylene glycol Polymers 0.000 description 10
- MTHSVFCYNBDYFN-UHFFFAOYSA-N diethylene glycol Chemical compound OCCOCCO MTHSVFCYNBDYFN-UHFFFAOYSA-N 0.000 description 8
- -1 sodium ethoxy alkyl sulfate Chemical class 0.000 description 7
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 6
- 210000003743 erythrocyte Anatomy 0.000 description 5
- 239000007791 liquid phase Substances 0.000 description 5
- 229920001343 polytetrafluoroethylene Polymers 0.000 description 5
- 239000004810 polytetrafluoroethylene Substances 0.000 description 5
- 230000008569 process Effects 0.000 description 5
- 238000012360 testing method Methods 0.000 description 5
- LYCAIKOWRPUZTN-UHFFFAOYSA-N Ethylene glycol Chemical compound OCCO LYCAIKOWRPUZTN-UHFFFAOYSA-N 0.000 description 4
- 239000008118 PEG 6000 Substances 0.000 description 4
- 229920002584 Polyethylene Glycol 6000 Polymers 0.000 description 4
- 238000002835 absorbance Methods 0.000 description 4
- 229920002523 polyethylene Glycol 1000 Polymers 0.000 description 4
- 238000005086 pumping Methods 0.000 description 4
- 239000002994 raw material Substances 0.000 description 4
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 4
- 102000001554 Hemoglobins Human genes 0.000 description 3
- 108010054147 Hemoglobins Proteins 0.000 description 3
- 238000002441 X-ray diffraction Methods 0.000 description 3
- 230000000052 comparative effect Effects 0.000 description 3
- 238000002425 crystallisation Methods 0.000 description 3
- 230000008025 crystallization Effects 0.000 description 3
- 230000002439 hemostatic effect Effects 0.000 description 3
- 238000011068 loading method Methods 0.000 description 3
- 238000002844 melting Methods 0.000 description 3
- 230000008018 melting Effects 0.000 description 3
- 239000011259 mixed solution Substances 0.000 description 3
- 238000001179 sorption measurement Methods 0.000 description 3
- 238000001228 spectrum Methods 0.000 description 3
- RCEAADKTGXTDOA-UHFFFAOYSA-N OS(O)(=O)=O.CCCCCCCCCCCC[Na] Chemical compound OS(O)(=O)=O.CCCCCCCCCCCC[Na] RCEAADKTGXTDOA-UHFFFAOYSA-N 0.000 description 2
- 229920002582 Polyethylene Glycol 600 Polymers 0.000 description 2
- 229920002593 Polyethylene Glycol 800 Polymers 0.000 description 2
- 230000009286 beneficial effect Effects 0.000 description 2
- 238000004132 cross linking Methods 0.000 description 2
- 239000008367 deionised water Substances 0.000 description 2
- 229910021641 deionized water Inorganic materials 0.000 description 2
- 238000000113 differential scanning calorimetry Methods 0.000 description 2
- 238000011056 performance test Methods 0.000 description 2
- 238000013112 stability test Methods 0.000 description 2
- OVRNDRQMDRJTHS-UHFFFAOYSA-N N-acelyl-D-glucosamine Natural products CC(=O)NC1C(O)OC(CO)C(O)C1O OVRNDRQMDRJTHS-UHFFFAOYSA-N 0.000 description 1
- OVRNDRQMDRJTHS-FMDGEEDCSA-N N-acetyl-beta-D-glucosamine Chemical compound CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O OVRNDRQMDRJTHS-FMDGEEDCSA-N 0.000 description 1
- MBLBDJOUHNCFQT-LXGUWJNJSA-N N-acetylglucosamine Natural products CC(=O)N[C@@H](C=O)[C@@H](O)[C@H](O)[C@H](O)CO MBLBDJOUHNCFQT-LXGUWJNJSA-N 0.000 description 1
- 238000010521 absorption reaction Methods 0.000 description 1
- 125000000218 acetic acid group Chemical group C(C)(=O)* 0.000 description 1
- 230000032683 aging Effects 0.000 description 1
- 230000000740 bleeding effect Effects 0.000 description 1
- 210000001772 blood platelet Anatomy 0.000 description 1
- 239000012876 carrier material Substances 0.000 description 1
- 238000005119 centrifugation Methods 0.000 description 1
- 239000000701 coagulant Substances 0.000 description 1
- 238000013329 compounding Methods 0.000 description 1
- 230000001351 cycling effect Effects 0.000 description 1
- 238000011161 development Methods 0.000 description 1
- 230000018109 developmental process Effects 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 238000004146 energy storage Methods 0.000 description 1
- 235000019441 ethanol Nutrition 0.000 description 1
- 230000007717 exclusion Effects 0.000 description 1
- 210000000416 exudates and transudate Anatomy 0.000 description 1
- 230000002349 favourable effect Effects 0.000 description 1
- 150000004676 glycans Chemical class 0.000 description 1
- 229910052739 hydrogen Inorganic materials 0.000 description 1
- 239000001257 hydrogen Substances 0.000 description 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 description 1
- 238000005470 impregnation Methods 0.000 description 1
- 238000002372 labelling Methods 0.000 description 1
- 239000011159 matrix material Substances 0.000 description 1
- 239000000155 melt Substances 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 229950006780 n-acetylglucosamine Drugs 0.000 description 1
- 231100000252 nontoxic Toxicity 0.000 description 1
- 230000003000 nontoxic effect Effects 0.000 description 1
- 230000000149 penetrating effect Effects 0.000 description 1
- 230000010399 physical interaction Effects 0.000 description 1
- 229920001282 polysaccharide Polymers 0.000 description 1
- 239000005017 polysaccharide Substances 0.000 description 1
- 239000002243 precursor Substances 0.000 description 1
- 230000002947 procoagulating effect Effects 0.000 description 1
- 239000000047 product Substances 0.000 description 1
- 238000011160 research Methods 0.000 description 1
- 238000005245 sintering Methods 0.000 description 1
- DAJSVUQLFFJUSX-UHFFFAOYSA-M sodium;dodecane-1-sulfonate Chemical compound [Na+].CCCCCCCCCCCCS([O-])(=O)=O DAJSVUQLFFJUSX-UHFFFAOYSA-M 0.000 description 1
- 238000006467 substitution reaction Methods 0.000 description 1
- 239000006228 supernatant Substances 0.000 description 1
- 238000001132 ultrasonic dispersion Methods 0.000 description 1
- 238000009489 vacuum treatment Methods 0.000 description 1
Images
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L24/00—Surgical adhesives or cements; Adhesives for colostomy devices
- A61L24/02—Surgical adhesives or cements; Adhesives for colostomy devices containing inorganic materials
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L24/00—Surgical adhesives or cements; Adhesives for colostomy devices
- A61L24/001—Use of materials characterised by their function or physical properties
- A61L24/0015—Medicaments; Biocides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L24/00—Surgical adhesives or cements; Adhesives for colostomy devices
- A61L24/001—Use of materials characterised by their function or physical properties
- A61L24/0036—Porous materials, e.g. foams or sponges
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L24/00—Surgical adhesives or cements; Adhesives for colostomy devices
- A61L24/04—Surgical adhesives or cements; Adhesives for colostomy devices containing macromolecular materials
- A61L24/046—Surgical adhesives or cements; Adhesives for colostomy devices containing macromolecular materials obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L24/00—Surgical adhesives or cements; Adhesives for colostomy devices
- A61L24/04—Surgical adhesives or cements; Adhesives for colostomy devices containing macromolecular materials
- A61L24/08—Polysaccharides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L26/00—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form
- A61L26/0004—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form containing inorganic materials
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L26/00—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form
- A61L26/0009—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form containing macromolecular materials
- A61L26/0019—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form containing macromolecular materials obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L26/00—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form
- A61L26/0009—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form containing macromolecular materials
- A61L26/0023—Polysaccharides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L26/00—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form
- A61L26/0061—Use of materials characterised by their function or physical properties
- A61L26/0066—Medicaments; Biocides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L26/00—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form
- A61L26/0061—Use of materials characterised by their function or physical properties
- A61L26/0085—Porous materials, e.g. foams or sponges
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/20—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing organic materials
- A61L2300/23—Carbohydrates
- A61L2300/232—Monosaccharides, disaccharides, polysaccharides, lipopolysaccharides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
- A61L2300/418—Agents promoting blood coagulation, blood-clotting agents, embolising agents
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Materials Engineering (AREA)
- Surgery (AREA)
- Inorganic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Dispersion Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Materials For Medical Uses (AREA)
Abstract
The embodiment of the invention relates to the field of phase-change materials, and particularly relates to a carbon fiber-based porous material, a preparation method and application thereof. The preparation method comprises the following steps: mixing carbon material, adhesive and blood coagulation component, freezing-thawing, and freeze drying to obtain the final product; the blood coagulation component comprises chitin or chitosan and derivatives thereof; adsorbing a phase change core material in the carbon fiber-based porous material. The method comprises the steps of introducing a blood coagulation component into a skeleton of a carbon material by a freezing-unfreezing method, and freeze-drying to obtain a shape-controllable flexible carbon fiber-based porous material, wherein the carbon fiber-based porous material is used as a porous carrier, a phase-change core material can be adsorbed and fixed in a pore channel of the phase-change core material, and the phase-change core material has a large load capacity on the phase-change core material, so that the obtained carbon fiber-based composite phase-change material has the functions of controllable temperature, long temperature control time and procoagulant blood, and can meet the requirements of different types of wound coagulation and healing on proper temperature, particularly burn wounds.
Description
Technical Field
The invention relates to the field of phase-change materials, in particular to a carbon fiber-based porous material, a preparation method and application thereof.
Background
With the accelerated aging process of population and the increase of middle-aged and young-aged wounds, the amount of surgical operations in China is rapidly increased, and bleeding and oozing blood in the operations are the first problems to be solved clinically, so that the preparation of the hemostatic material is extremely important.
Different wounds can have different requirements on temperature, for example, burn wounds can be healed, and the existing research shows that the temperature of 34-37 ℃ is favorable for promoting the coagulation and healing of the wound of the burn patient. Therefore, the development of the temperature-controllable hemostatic material has important significance for the treatment of the wound surface of a patient.
The chitosan is a product of removing partial acetyl of natural polysaccharide chitin (N-acetyl glucosamine), and has good biocompatibility and biodegradability. Because of its positive charge, it can attract the blood red blood cells and blood platelets with negative charge, so that it is an effective hemostatic.
In the Phase Change Material (Phase Change Material), the temperature of the Material floats in a small range and is approximately constant in the Phase Change energy storage process. Among them, the solid-liquid phase change material is the most widely used phase change material, and the solid-liquid phase change material has a solid-liquid phase change in the phase change process, but the direct application thereof has a serious leakage problem. In order to avoid leakage of the solid-liquid phase change material in the liquid phase state, the composite phase change material needs to be prepared and shaped. The commonly used styling methods include: preparing a shaped phase change material by compounding the phase change material with a porous material; the porous material can effectively load the phase-change core material in the pore channel by utilizing the surface tension, the capillary force or the hydrogen bond force of the pore channel.
The information disclosed in this background section is only for enhancement of understanding of the general background of the invention and should not be taken as an acknowledgement or any form of suggestion that this information forms the prior art already known to a person skilled in the art.
Disclosure of Invention
Object of the Invention
In order to solve the technical problems, the invention aims to provide a carbon fiber-based porous material, a preparation method and application thereof. The preparation method of the carbon fiber-based porous material provided by the invention is characterized in that a coagulation component is introduced into a skeleton of a carbon material by a freezing-unfreezing method, and the shape-controllable flexible carbon fiber-based porous material is obtained by freeze drying. The carbon fiber-based composite phase-change material is used as a porous carrier, the phase-change core material can be adsorbed and fixed in a pore channel of the porous carrier, and the loading capacity of the porous carrier to the phase-change core material is large, so that the obtained carbon fiber-based composite phase-change material has the functions of controllable temperature, long temperature control time and procoagulant blood, and can meet the requirements of different types of wound surface coagulation and healing on proper temperature, especially burn wounds.
Solution scheme
To achieve the object of the present invention, an embodiment of the present invention provides a method for preparing a carbon fiber-based porous material, including the steps of:
mixing carbon material, adhesive and blood coagulation component, freezing-thawing, and freeze drying to obtain the final product; the blood coagulation component comprises chitin or chitosan and derivatives thereof. By freeze-thawing, cross-linking between the raw materials occurs. During the freeze-drying process, water is sublimated, many pores are left, and thus a porous structure is formed, and the freeze-drying can keep the original structure of the material and cannot cause collapse.
In one possible implementation, the preparation method of the carbon fiber-based porous material comprises the steps of freezing-unfreezing circulation for 2 times or more; optionally, freeze-thaw cycling 2-7 times; further optionally, the freeze-thaw cycle is 3-5 times.
In one possible implementation of the above method for preparing a carbon fiber-based porous material, the coagulation component comprises chitosan.
In a possible implementation manner, the mass ratio of the carbon material to the coagulation component is 1-100: 1-100; optionally 1: 1-10; further optionally 1: 1.
in one possible implementation mode of the preparation method of the carbon fiber-based porous material, the mass of the adhesive is 1-10% of the mass of the carbon material; alternatively 3-8%; further optionally 5%.
In one possible implementation of the above method for preparing a carbon-fiber-based porous material, one cycle of freezing-thawing comprises the following steps: freezing at-15-25 deg.C for 5-20h, and thawing at 3-6 deg.C for 3-15 h; optionally, after freezing at-15-25 deg.C for 10-15h, thawing at 3-6 deg.C for 5-10 h.
In one possible implementation manner, the preparation method of the carbon fiber-based porous material comprises the following steps: dispersing the carbon material with a dispersant, adding a binder and a coagulant, and mixing.
In one possible implementation manner, the mixing method of the carbon fiber-based porous material comprises the following steps: violently stirring for 1-5 h at 85-95 ℃, then cooling to below 50 ℃, and pouring into a mold.
In one possible implementation of the above method for preparing a carbon fiber-based porous material, the concentration of the dispersant is 1 to 5 wt%.
In one possible implementation manner, the step of freeze-drying comprises the following steps: drying in a freeze dryer with pressure of 25-70mT and temperature of-50-70 deg.C for 24-48 h.
In one possible implementation manner, the carbon material includes one or more of carbon nanotubes, carbon nanofibers, or graphene.
In one possible implementation manner, the preparation method of the carbon fiber-based porous material includes: one or more of polyvinyl alcohol, starch, dextrin or carboxymethyl cellulose.
In one possible implementation manner, the dispersant includes: one or more of sodium dodecyl benzene sulfonate, sodium dodecyl sulfate, sodium dodecyl sulfonate, polyacrylic acid, sodium ethoxy alkyl sulfate or ammonium ethoxy alkyl sulfate; optionally one or more of sodium dodecyl sulfate, polyacrylic acid, or sodium dodecyl benzene sulfonate.
The embodiment of the invention also provides the carbon fiber-based porous material prepared by the preparation method of the carbon fiber-based porous material.
The embodiment of the invention also provides a preparation method of the carbon fiber-based composite phase-change material, which comprises the following steps: phase change core materials are adsorbed in the carbon fiber-based porous material.
In a possible implementation manner of the preparation method of the carbon fiber-based composite phase-change material, the mass ratio of the phase-change core material to the carbon fiber-based porous material is 1-100: 1-100; alternatively 1-10: 1-10.
In a possible implementation manner, the adsorption is realized by a solution impregnation method, an adsorption method, a melt blending method or a sintering method.
In a possible implementation manner, the preparation method of the carbon fiber-based composite phase-change material is characterized in that before adsorption, the carbon fiber-based porous material is subjected to vacuum pumping treatment: and vacuumizing the carbon fiber-based porous material for 5-24h at the temperature of 60-80 ℃. The treatment can completely open the pore channels of the carbon fiber-based porous material, so as to be beneficial to subsequent loading of the phase-change core material.
In a possible implementation manner, the preparation method of the carbon fiber-based composite phase-change material comprises the following steps: dissolving the phase-change core material in ethanol or water to obtain a phase-change core material solution; then dispersing the carbon fiber-based porous material subjected to vacuum treatment in the phase-change core material solution, and stirring; drying in an oven at 60-90 deg.C for 12-36 h.
In a possible implementation manner, the preparation method of the carbon fiber-based composite phase-change material includes: polyethylene glycol (PEG); the average molecular weight of the polyethylene glycol is 600-; optionally, the polyethylene glycol has an average molecular weight of 800-; further alternatively, the polyethylene glycol has an average molecular weight of 1000.
The embodiment of the invention also provides the carbon fiber-based composite phase change material prepared by the preparation method of the carbon fiber-based composite phase change material.
The embodiment of the invention also provides a preparation method of the carbon fiber-based porous material, a preparation method of the carbon fiber-based composite phase-change material or an application of the carbon fiber-based composite phase-change material in preparation of a material for treating wounds.
In one possible implementation, the treatment of the wound comprises promoting coagulation of the wound.
In one possible implementation, the treatment of the wound includes promoting coagulation of a burn wound.
Advantageous effects
(1) According to the preparation method of the carbon fiber-based porous material provided by the embodiment of the invention, the coagulation component is introduced into the skeleton of the carbon material by a freezing-unfreezing method, and the shape-controllable flexible carbon fiber-based porous material is obtained by freeze drying. The carbon fiber-based composite phase change material can be used as a porous carrier, and phase change core materials can be adsorbed and fixed in pore channels of the porous carrier, so that the obtained carbon fiber-based composite phase change material has the functions of temperature control and procoagulant, and can meet the requirements of different types of wound coagulation and healing on proper temperature, especially the requirements of wound coagulation and healing of burn patients on proper temperature. In addition, the carbon fiber-based porous material has high load on the phase change core material, and the highest load can reach 92 wt%, so that the obtained carbon fiber-based composite phase change material has long temperature control time.
In the preparation method, the adhesive is used for connecting the blood coagulation component and the carbon material, and the adhesive can form cross-linking points with the blood coagulation component; the addition of the adhesive can ensure that the obtained carbon fiber-based porous material has good mechanical properties. When the raw materials are not added with the adhesive, the obtained carbon fiber-based composite phase change material has a loose structure and extremely poor practicability.
(2) According to the preparation method of the carbon fiber-based porous material provided by the embodiment of the invention, through a freezing-unfreezing process with proper cycle times, the carbon material, the adhesive and the blood coagulation component are fully crosslinked through hydroxyl and the like on the carbon material, so that the carbon fiber-based porous material with controllable shape and good toughness can be obtained; if the circulation frequency is small, the obtained carbon fiber-based porous material has poor toughness and poor processability.
(3) According to the preparation method of the carbon fiber-based porous material provided by the embodiment of the invention, the shape of the prepared carbon fiber-based porous material can be changed by changing the shape of the mold so as to adapt to wounds with different shapes.
(4) According to the preparation method of the carbon fiber-based porous material provided by the embodiment of the invention, the carbon material is uniformly dispersed by using the dispersing agent, so that the carbon material is prevented from agglomerating, and the prepared carbon fiber-based porous material has a more uniform structure.
(5) According to the preparation method of the carbon fiber-based composite phase change material provided by the embodiment of the invention, the prepared carbon fiber-based porous material is used as a porous carrier, and the obtained carbon fiber-based composite phase change material has the functions of controlling temperature and promoting coagulation, and can meet the requirements of different types of wound surface coagulation and healing on proper temperature; and the temperature control time is long, the circulation stability is good, and the phase change enthalpy value and the phase change temperature do not have large deviation after 50 times of melting crystallization circulation.
(6) According to the preparation method of the carbon fiber-based composite phase-change material provided by the embodiment of the invention, the phase-change core material is diversified in selection and can be selected according to the temperature required by coagulation and healing of different types of wounds.
For example, when polyethylene glycol is used as the phase change core material, the higher the molecular weight of polyethylene glycol, the higher the phase change temperature, e.g., about 65 ℃ for PEG10000, about 50 ℃ for PEG2000, about 37 ℃ for PEG1000, about 28 ℃ for PEG 800, and about 20 ℃ for PEG 600. The carbon fiber-based composite phase-change material obtained by taking PEG1000 as the phase-change core material can control the temperature within the proper temperature range required by the coagulation and healing of burn wounds, and is extremely beneficial to the coagulation and healing of the burn wounds as the temperature-control coagulation material.
(7) According to the preparation method of the carbon fiber-based composite phase change material provided by the embodiment of the invention, the selected chitosan has good biocompatibility, all raw materials are green and environment-friendly, and the obtained carbon fiber-based composite phase change material is safe and non-toxic; and the chitosan, the adhesive and the phase-change core material are all hydrophilic materials, and wound exudate can be absorbed through the porous structure on the surface of the composite material, so that the carbon fiber-based composite phase-change material can be more widely applied to the field of wound treatment.
Drawings
One or more embodiments are illustrated by the corresponding figures in the drawings, which are not meant to be limiting. The word "exemplary" is used exclusively herein to mean "serving as an example, embodiment, or illustration. Any embodiment described herein as "exemplary" is not necessarily to be construed as preferred or advantageous over other embodiments.
Fig. 1 is a Scanning Electron Microscope (SEM) spectrum of a carbon fiber-based porous material provided in example 1 of the present invention.
Fig. 2 is an X-ray diffraction (XRD) pattern of the carbon fiber-based porous material provided in example 1 of the present invention.
Fig. 3 is a Differential Scanning Calorimetry (DSC) spectrum of the carbon fiber-based composite phase change material provided in example 1 of the present invention.
Fig. 4 is a result of a cycle stability test of the carbon fiber-based composite phase change material provided in embodiment 1 of the present invention.
Fig. 5 is a photograph of a carbon fiber-based porous material provided in example 3 of the present invention (left) and a material provided in comparative example 1 (right).
Fig. 6 is a graph of hemoglobin absorbance of the carbon fiber-based composite phase change material provided in embodiments 1 to 3 of the present invention.
Detailed Description
In order to make the objects, technical solutions and advantages of the embodiments of the present invention clearer, the technical solutions in the embodiments of the present invention will be clearly and completely described below, and it is obvious that the described embodiments are a part of the embodiments of the present invention, but not all of the embodiments. All other embodiments, which can be derived by a person skilled in the art from the embodiments given herein without making any creative effort, shall fall within the protection scope of the present invention. Throughout the specification and claims, unless explicitly stated otherwise, the word "comprise", or variations such as "comprises" or "comprising", will be understood to imply the inclusion of a stated element or component but not the exclusion of any other element or component.
Furthermore, in the following detailed description, numerous specific details are set forth in order to provide a better understanding of the present invention. It will be understood by those skilled in the art that the present invention may be practiced without some of these specific details. In some embodiments, materials, elements, methods, means, and the like that are well known to those skilled in the art are not described in detail in order to not unnecessarily obscure the present invention.
In the following examples, the raw materials used are all commercially available materials, wherein carbon nanotubes were purchased from nano era, type: TNMC;
chitosan was purchased from alatin, viscosity 200-;
PEG, polyacrylic acid, dextrin, and starch were purchased from Aladdin;
polyvinyl alcohol was purchased from the national pharmaceutical group.
In the following examples, PEG10000, PEG2000 and PEG1000 are selected as the phase change core material for illustration, and in practical application, PEG with different molecular weights, such as PEG6000, PEG 800, PEG600, etc., can be selected according to different requirements.
Example 1
1. A method for preparing a carbon fiber-based porous material, the method comprising the steps of:
ultrasonically dispersing 10g of sodium dodecyl benzene sulfonate with the mass fraction of 2 wt% for a carbon nano tube, and then adding 10g of chitosan and 1g of polyvinyl alcohol; stirring vigorously at 95 deg.C for 2h, cooling to below 50 deg.C, and pouring into a mold made of polytetrafluoroethylene plate; the polytetrafluoroethylene plate has good tolerance to low temperature, and a sample is easy to take out;
freezing the mould at-23 deg.C for 12h, and thawing at 5 deg.C for 8h, which is a cycle of freezing-thawing, and performing 3 cycles;
and taking out the sample from the mold, and drying the sample in a freeze dryer with the pressure of 30mT and the temperature of-70 ℃ for 48 hours to obtain the carbon fiber-based porous material.
The SEM (scanning electron microscope) pattern of the prepared carbon fiber-based porous material is shown in figure 1, and the XRD (X-ray diffraction) pattern is shown in figure 2. As can be seen from fig. 1, the prepared carbon fiber-based porous material has a dense three-dimensional network porous structure penetrating each other, and a plurality of stacked macropores exist in the structure; as can be seen from fig. 2, the characteristic diffraction peaks of chitosan, polyvinyl alcohol and carbon nanotubes exist in the carbon fiber-based porous material, and no new peaks appear, indicating that there is a physical interaction between the precursor components, which are cross-linked together.
In this embodiment, the mass ratio of the chitosan to the carbon material may be 5: 1 or 10: 1, slightly different hardness of the prepared carbon fiber-based porous material with different addition amounts of chitosan; the more the chitosan is added, the harder the prepared carbon fiber-based porous material is.
2. A preparation method of a carbon fiber-based composite phase-change material comprises the following steps:
dissolving 0.5g of PEG10000 in 30mL of absolute ethyl alcohol, and stirring for 1h at 80 ℃ to obtain a uniform PEG10000 solution;
0.055g of the prepared carbon fiber-based porous material is vacuumized for 12 hours at the temperature of 60 ℃; this step allows the channels of the matrix to be completely open;
then dispersing the carbon fiber-based porous material subjected to vacuum pumping treatment in the PEG10000 solution, and stirring for 5 hours at 80 ℃; and then, drying the mixed solution in an oven at 80 ℃ for 24h to obtain the carbon fiber-based composite phase-change material with the PEG10000 loaded on the carbon fiber-based porous material.
The Differential Scanning Calorimetry (DSC) spectrum of the prepared carbon fiber-based composite phase-change material is shown in figure 3; as can be seen from FIG. 3, the maximum loading of the carbon fiber-based composite phase change material can reach 92 wt%, the melting enthalpy is 150J/g, and the crystallization enthalpy is 164.8J/g.
The result of the cycle stability test of the carbon fiber-based composite phase-change material is shown in figure 4; as can be seen from fig. 4, the cycle stability of the carbon fiber-based composite phase change material is good, and the enthalpy value of phase change and the phase change temperature do not greatly shift after 50 cycles of melting and crystallization.
Example 2
1. A method for preparing a carbon fiber-based porous material, the method comprising the steps of:
after 20g of polyacrylic acid with the mass fraction of 3 wt% for the carbon nanotube is subjected to ultrasonic dispersion, 20g of chitosan and 1g of starch are added; stirring vigorously at 95 deg.C for 3h, cooling to below 50 deg.C, and pouring into a mold made of polytetrafluoroethylene plate;
freezing the mould at-15 deg.C for 12h, and thawing at 5 deg.C for 8h, which is a cycle of freezing-thawing, and performing 3 cycles;
and taking out the sample from the mold, and drying the sample in a freeze dryer with the pressure of 30mT and the temperature of-70 ℃ for 24 hours to obtain the carbon fiber-based porous material.
2. A preparation method of a carbon fiber-based composite phase-change material comprises the following steps:
dissolving 0.5g of PEG2000 in 30mL of absolute ethyl alcohol, and stirring for 1h at 80 ℃ to obtain a uniform PEG2000 solution;
vacuumizing 0.125g of the prepared carbon fiber-based porous material for 12 hours at the temperature of 70 ℃;
then dispersing the carbon fiber-based porous material subjected to vacuum pumping treatment in the PEG2000 solution, and stirring for 5 hours at 60 ℃; and then, drying the mixed solution in an oven at 80 ℃ for 36h to obtain the carbon fiber-based composite phase-change material of the carbon fiber-based porous material loaded with PEG 2000.
Example 3
1. A method for preparing a carbon fiber-based porous material, the method comprising the steps of:
30g of carbon nanotube is ultrasonically dispersed by using 5 wt% of lauryl sodium sulfate, and then 30g of chitosan and 3g of carboxymethyl cellulose are added; stirring vigorously at 95 deg.C for 5h, cooling to 50 deg.C, and pouring into a mold made of polytetrafluoroethylene plate;
freezing the mould at-15 deg.C for 12h, and thawing at 5 deg.C for 8h, which is a cycle of freezing-thawing, and performing 3 cycles;
and taking out the sample from the mold, and drying the sample in a freeze dryer with the pressure of 30mT and the temperature of-70 ℃ for 36 hours to obtain the carbon fiber-based porous material.
2. A preparation method of a carbon fiber-based composite phase-change material comprises the following steps:
dissolving 0.5g of PEG1000 in 30mL of absolute ethyl alcohol, and stirring at 80 ℃ for 1h to obtain a uniform PEG6000 solution;
vacuumizing 0.125g of the prepared carbon fiber-based porous material for 12 hours at the temperature of 60 ℃;
then dispersing the carbon fiber-based porous material subjected to vacuum pumping treatment in the PEG6000 solution, and stirring for 5 hours at 80 ℃; and then, drying the mixed solution in an oven at 80 ℃ for 24h to obtain the carbon fiber-based composite phase change material of the carbon fiber-based porous carrier material loaded with PEG 6000.
Comparative example 1
A method for preparing a carbon fiber-based porous material, the method comprising the steps of:
30g of carbon nanotube is ultrasonically dispersed by lauryl sodium sulfate with the mass fraction of 5 wt%, and then 30g of chitosan is added; stirring vigorously at 95 deg.C for 5h, cooling to 50 deg.C, and pouring into a mold made of polytetrafluoroethylene plate;
freezing the mould at-15 deg.C for 12h, and thawing at 5 deg.C for 8h, which is a cycle of freezing-thawing, and performing 3 cycles;
taking out the sample from the mold, and drying the sample in a freeze dryer with the pressure of 30mT and the temperature of-70 ℃ for 36h to obtain the material with a loose structure. The resulting material was photographed, see fig. 5; in FIG. 5, the carbon fiber-based porous material obtained in example 3 is shown on the left, and the structurally loose material prepared in comparative example 1 without a binder is shown on the right.
Test examples blood coagulation Performance test
The carbon fiber-based composite phase change materials prepared in examples 1 to 3 were subjected to a standard coagulation performance test.
Taking the carbon fiber-based composite phase change material prepared in the embodiment 1 as an example, 3 parts are respectively prepared on the carbon fiber-based composite phase change material to prepare 3 samples (1 × 1cm) for testing, and the average value of the test results is taken to be a sample one; similarly, the carbon fiber-based composite phase change materials prepared in examples 2 and 3 are respectively designated as sample two and sample three; the specific test process is as follows:
putting the sample into a 6-well plate, and taking medical gauze of 1 × 1cm as an experimental control;
50 μ l of anticoagulated whole blood and 5 μ l of 0.2MCaCl were taken2Dropwise adding the solution on the surface of a sample, and statically incubating for 5min at 37 ℃;
adding 5mL of deionized water into the pore plate along the edge of the 6 pore plate, slightly shaking, and statically incubating at room temperature for 10min to ensure that unsolidified red blood cells are hemolyzed;
adding 50 μ l of anticoagulated whole blood directly into 5mL of deionized water, and incubating at 37 ℃ for 5min to serve as a blank group;
after the solution is mixed by gentle shaking, 1mL of solution sample is added into a 1.5mL centrifuge tube, centrifugation is carried out at 3000rpm for 5min, 0.2mL of supernatant is absorbed and moved into a 96-well plate, an absorbance value at 540nm is measured by an enzyme-labeling instrument, the absorbance value is measured for three times, and an average value is obtained; the greater the absorbance value, the higher the concentration of hemoglobin in the solution, the greater the number of lysed erythrocytes, the lower the number of coagulated erythrocytes and the lower the procoagulant properties of the sample, and vice versa.
The test results are shown in FIG. 6; as can be seen from fig. 6, the absorption value of the unsolidified red blood cells of the carbon fiber-based composite phase-change material prepared in examples 1 to 3 on hemoglobin is much lower than that of medical gauze, which indicates that the composite phase-change material has good coagulation ability.
Finally, it should be noted that: the above examples are only intended to illustrate the technical solution of the present invention, but not to limit it; although the present invention has been described in detail with reference to the foregoing embodiments, it will be understood by those of ordinary skill in the art that: the technical solutions described in the foregoing embodiments may still be modified, or some technical features may be equivalently replaced; and such modifications or substitutions do not depart from the spirit and scope of the corresponding technical solutions of the embodiments of the present invention.
Claims (11)
1. A method for preparing a carbon fiber-based porous material for use in the preparation of a wound treatment material, the method comprising the steps of:
dispersing carbon material with dispersant, adding binder and coagulation component, and mixing; the mixing comprises the following steps: violently stirring for 1-5 h at 85-95 ℃, then cooling to below 50 ℃, and pouring into a mold; wherein the mass ratio of the carbon material to the coagulation component is 1-100: 1-100; the mass of the adhesive is 1% -10% of that of the carbon material;
then freezing-unfreezing, freezing and drying to obtain the product; wherein the freezing-thawing cycle is performed for 2 times or more; one cycle of freeze-thaw includes the steps of: freezing at-15 to-25 deg.C for 5-20h, and thawing at 3-6 deg.C for 3-15 h;
the blood coagulation component is chitin, chitosan or chitosan derivative;
the adhesive comprises: one or more of polyvinyl alcohol, starch, dextrin or carboxymethyl cellulose;
the carbon material includes one or more of carbon nanotubes, carbon nanofibers, or graphene.
2. The method according to claim 1, wherein the coagulation component is chitosan.
3. The method of claim 1, wherein the freeze-thaw cycle is performed 2 to 7 times.
4. The production method according to claim 1, wherein the mass ratio of the carbon material to the blood coagulation component is 1: 1-10.
5. The method of claim 1, wherein the step of freeze-drying comprises: drying in a freeze dryer with pressure of 25-70mT and temperature of-50 to-70 deg.C for 24-48 h.
6. The method according to claim 1, wherein the concentration of the dispersant is 1 to 5 wt%.
7. The production method according to claim 1, wherein the dispersant comprises: one or more of sodium dodecylbenzene sulfonate, sodium dodecyl sulfate, polyacrylic acid, sodium ethoxyalkyl sulfate, or ammonium ethoxyalkyl sulfate.
8. A carbon fiber-based porous material for use in the preparation of a material for treating wounds, which is obtained by the production method according to any one of claims 1 to 7.
9. Use of the preparation method of claim 1 or the carbon fiber-based porous material for preparing a wound healing material of claim 8 in the preparation of a wound healing material.
10. The use of claim 9, wherein treating a wound comprises promoting coagulation of the wound.
11. The use of claim 9, wherein treating a wound comprises promoting coagulation of a burn wound.
Priority Applications (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201911386806.8A CN111097065B (en) | 2019-12-29 | 2019-12-29 | Carbon fiber-based porous material, preparation method and application thereof |
| PCT/CN2020/093102 WO2021135060A1 (en) | 2019-12-29 | 2020-05-29 | Carbon fiber-based porous material, carbon fiber-based composite phase-change material, preparation method, and use thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201911386806.8A CN111097065B (en) | 2019-12-29 | 2019-12-29 | Carbon fiber-based porous material, preparation method and application thereof |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN111097065A CN111097065A (en) | 2020-05-05 |
| CN111097065B true CN111097065B (en) | 2021-09-07 |
Family
ID=70423856
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201911386806.8A Active CN111097065B (en) | 2019-12-29 | 2019-12-29 | Carbon fiber-based porous material, preparation method and application thereof |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN111097065B (en) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2021135060A1 (en) * | 2019-12-29 | 2021-07-08 | 苏州阿德旺斯新材料有限公司 | Carbon fiber-based porous material, carbon fiber-based composite phase-change material, preparation method, and use thereof |
| CN113621348B (en) * | 2021-08-16 | 2023-08-15 | 山东建筑大学 | High-heat-conductivity phase change material based on chitin derived carbon, preparation method and heat storage application thereof |
Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101792540A (en) * | 2010-02-23 | 2010-08-04 | 厦门大学 | Carbon nano tube chitosan composite membrane and preparation method thereof |
| WO2010123989A1 (en) * | 2009-04-21 | 2010-10-28 | University Of Memphis Research Foundation | Chitosan/carbon nanotube composite scaffolds for drug delivery |
| CN106400199A (en) * | 2016-08-31 | 2017-02-15 | 奥美医疗用品股份有限公司 | Phase change and temperature adjustment microcapsule material, preparation method thereof and prepared dressing |
| CN106902778A (en) * | 2017-04-28 | 2017-06-30 | 武汉理工大学 | A kind of chitosan/oxidized Graphene/polyvinyl alcohol cellular composite adsorbing material and preparation method thereof |
| CN109266314A (en) * | 2018-11-16 | 2019-01-25 | 北京师范大学 | A kind of flexible compound phase-change material and preparation method thereof |
| CN109897235A (en) * | 2019-01-31 | 2019-06-18 | 华南理工大学 | A kind of chitin/graphene composite sponge and preparation method and application |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US10639592B2 (en) * | 2017-08-07 | 2020-05-05 | Board Of Trustees Of The University Of Arkansas | Chitosan-graphene oxide membranes and process of making the same |
-
2019
- 2019-12-29 CN CN201911386806.8A patent/CN111097065B/en active Active
Patent Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2010123989A1 (en) * | 2009-04-21 | 2010-10-28 | University Of Memphis Research Foundation | Chitosan/carbon nanotube composite scaffolds for drug delivery |
| CN101792540A (en) * | 2010-02-23 | 2010-08-04 | 厦门大学 | Carbon nano tube chitosan composite membrane and preparation method thereof |
| CN106400199A (en) * | 2016-08-31 | 2017-02-15 | 奥美医疗用品股份有限公司 | Phase change and temperature adjustment microcapsule material, preparation method thereof and prepared dressing |
| CN106902778A (en) * | 2017-04-28 | 2017-06-30 | 武汉理工大学 | A kind of chitosan/oxidized Graphene/polyvinyl alcohol cellular composite adsorbing material and preparation method thereof |
| CN109266314A (en) * | 2018-11-16 | 2019-01-25 | 北京师范大学 | A kind of flexible compound phase-change material and preparation method thereof |
| CN109897235A (en) * | 2019-01-31 | 2019-06-18 | 华南理工大学 | A kind of chitin/graphene composite sponge and preparation method and application |
Also Published As
| Publication number | Publication date |
|---|---|
| CN111097065A (en) | 2020-05-05 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN111073606B (en) | Carbon fiber-based composite phase-change material, preparation method and application thereof | |
| CN111097065B (en) | Carbon fiber-based porous material, preparation method and application thereof | |
| Xu et al. | Morphological and swelling behavior of cellulose nanofiber (CNF)/poly (vinyl alcohol)(PVA) hydrogels: poly (ethylene glycol)(PEG) as porogen | |
| CN104511045B (en) | A kind of preparation method of the polyvinyl alcohol containing nano silver/chitosan nano fiber membrane dressing | |
| WO2016169398A1 (en) | In-situ crosslinking polymer binder for lithium-ion battery, and electrode manufactured by using same | |
| CN111303449B (en) | Degradable electroactive bacterial cellulose/MXene composite hydrogel and preparation and application thereof | |
| CN106110371A (en) | A kind of preparation method of high-hydroscopicity sodium alginate composite nano fiber wound dressing | |
| Zheng et al. | Study on hemostatic effect and mechanism of starch-based nano-microporous particles | |
| CN109881489B (en) | Multi-responsiveness intelligent nanofiber functional material and preparation method and application thereof | |
| Ren et al. | A self-healing hydrogel formation strategy via exploiting endothermic interactions between polyelectrolytes | |
| CN102908653A (en) | Preparation method of antiseptic dressing for deep infection wound | |
| Liu et al. | Potential of alginate fibers incorporated with drug-loaded nanocapsules as drug delivery systems | |
| CN109731121A (en) | A kind of preparation method of the cellulose containing mesoporous silicon oxide and chitosan combine dressing | |
| CN107742695B (en) | Preparation method of three-dimensional porous composite pole piece for flexible lithium ion battery | |
| CN109897235A (en) | A kind of chitin/graphene composite sponge and preparation method and application | |
| CN105295075A (en) | Preparation method of polyvinyl alcohol composite hydrogel with fast hydroscopicity, high swellbility and adjustable aperture sizes | |
| Zheng et al. | High‐Efficiency Antibacterial Hemostatic AgNP@ Zeolite/Chitin/Bamboo Composite Sponge for Wound Healing without Heat Injury | |
| WO2021135060A1 (en) | Carbon fiber-based porous material, carbon fiber-based composite phase-change material, preparation method, and use thereof | |
| Wang et al. | Antibacterial, anti-inflammatory, rapid hemostasis, and accelerated repair by multifunctional metal–organic frameworks fibrous scaffolds for diabetic wounds | |
| CN110229384B (en) | Silver-loaded diamidoxime cellulose/chitosan/fibroin composite aerogel and preparation method thereof | |
| Wang et al. | Fabrication of microspheres containing coagulation factors by reverse microemulsion method for rapid hemostasis and wound healing | |
| CN114522270B (en) | Preparation method of styptic powder | |
| CN115721767A (en) | Antibacterial healing-promoting porous medical dressing and preparation method thereof | |
| CN108689405A (en) | A kind of method that High Internal Phase Emulsion template prepares connection multi-stage porous carbon material | |
| Han et al. | Multifunctional hemostatic polysaccharide-based sponge enhanced by tunicate cellulose: A promising approach for photothermal antibacterial activity and accelerated wound healing |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| GR01 | Patent grant | ||
| GR01 | Patent grant | ||
| TR01 | Transfer of patent right | ||
| TR01 | Transfer of patent right |
Effective date of registration: 20240409 Address after: Room 401, 4th Floor, Building B, Building 6-1, Anmin Road, Panyang Industrial Park, Huangdai Town, Xiangcheng District, Suzhou City, Jiangsu Province, 215152 Patentee after: Suzhou Rongji New Materials Technology Co.,Ltd. Country or region after: China Address before: 215152 Room 401, no.6, Anmin Road, Dongqiao, Huangdai Town, Xiangcheng District, Suzhou City, Jiangsu Province Patentee before: SUZHOU ADEWANGSI NEW MATERIALS Co.,Ltd. Country or region before: China |