CN111097063A - Medical composite antibacterial wound surface coating product - Google Patents
Medical composite antibacterial wound surface coating product Download PDFInfo
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- CN111097063A CN111097063A CN201911401450.0A CN201911401450A CN111097063A CN 111097063 A CN111097063 A CN 111097063A CN 201911401450 A CN201911401450 A CN 201911401450A CN 111097063 A CN111097063 A CN 111097063A
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- 230000000844 anti-bacterial effect Effects 0.000 title claims abstract description 69
- 239000002131 composite material Substances 0.000 title claims abstract description 25
- 239000011248 coating agent Substances 0.000 title claims abstract description 18
- 238000000576 coating method Methods 0.000 title claims abstract description 18
- 239000010410 layer Substances 0.000 claims abstract description 97
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 39
- 239000002390 adhesive tape Substances 0.000 claims abstract description 13
- 239000002346 layers by function Substances 0.000 claims abstract description 12
- 239000012790 adhesive layer Substances 0.000 claims abstract description 11
- 230000003115 biocidal effect Effects 0.000 claims abstract description 10
- 239000004831 Hot glue Substances 0.000 claims abstract description 6
- 238000004026 adhesive bonding Methods 0.000 claims abstract 2
- 239000000243 solution Substances 0.000 claims description 30
- XLOMVQKBTHCTTD-UHFFFAOYSA-N Zinc monoxide Chemical compound [Zn]=O XLOMVQKBTHCTTD-UHFFFAOYSA-N 0.000 claims description 28
- 239000000047 product Substances 0.000 claims description 22
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 claims description 15
- 239000008367 deionised water Substances 0.000 claims description 15
- 229910021641 deionized water Inorganic materials 0.000 claims description 15
- 238000005303 weighing Methods 0.000 claims description 15
- 229910052802 copper Inorganic materials 0.000 claims description 14
- 239000010949 copper Substances 0.000 claims description 14
- 239000011787 zinc oxide Substances 0.000 claims description 14
- 239000011259 mixed solution Substances 0.000 claims description 10
- 229910000033 sodium borohydride Inorganic materials 0.000 claims description 10
- 239000012279 sodium borohydride Substances 0.000 claims description 10
- 239000002105 nanoparticle Substances 0.000 claims description 8
- RYGMFSIKBFXOCR-UHFFFAOYSA-N Copper Chemical compound [Cu] RYGMFSIKBFXOCR-UHFFFAOYSA-N 0.000 claims description 7
- 239000000654 additive Substances 0.000 claims description 6
- 230000000996 additive effect Effects 0.000 claims description 6
- HCHKCACWOHOZIP-UHFFFAOYSA-N Zinc Chemical compound [Zn] HCHKCACWOHOZIP-UHFFFAOYSA-N 0.000 claims description 5
- 238000005119 centrifugation Methods 0.000 claims description 5
- 238000004140 cleaning Methods 0.000 claims description 5
- 150000001879 copper Chemical class 0.000 claims description 5
- 238000001035 drying Methods 0.000 claims description 5
- 239000002245 particle Substances 0.000 claims description 5
- 239000002244 precipitate Substances 0.000 claims description 5
- 238000002360 preparation method Methods 0.000 claims description 5
- 150000003751 zinc Chemical class 0.000 claims description 5
- 239000011701 zinc Substances 0.000 claims description 5
- 229910052725 zinc Inorganic materials 0.000 claims description 5
- 238000011282 treatment Methods 0.000 claims description 4
- 238000002156 mixing Methods 0.000 claims description 3
- 238000001914 filtration Methods 0.000 claims description 2
- 238000005253 cladding Methods 0.000 claims 1
- 150000001875 compounds Chemical class 0.000 claims 1
- 206010052428 Wound Diseases 0.000 abstract description 29
- 208000027418 Wounds and injury Diseases 0.000 abstract description 29
- 230000029663 wound healing Effects 0.000 abstract description 10
- 230000001737 promoting effect Effects 0.000 abstract description 6
- 238000010521 absorption reaction Methods 0.000 description 19
- 239000000463 material Substances 0.000 description 12
- 239000004744 fabric Substances 0.000 description 7
- 238000013329 compounding Methods 0.000 description 6
- 238000007598 dipping method Methods 0.000 description 6
- 239000000835 fiber Substances 0.000 description 6
- 238000000034 method Methods 0.000 description 6
- 238000005507 spraying Methods 0.000 description 6
- 206010059866 Drug resistance Diseases 0.000 description 5
- BQCADISMDOOEFD-UHFFFAOYSA-N Silver Chemical compound [Ag] BQCADISMDOOEFD-UHFFFAOYSA-N 0.000 description 4
- 229910052709 silver Inorganic materials 0.000 description 4
- 239000004332 silver Substances 0.000 description 4
- 239000004475 Arginine Substances 0.000 description 3
- 102000008299 Nitric Oxide Synthase Human genes 0.000 description 3
- 108010021487 Nitric Oxide Synthase Proteins 0.000 description 3
- ODKSFYDXXFIFQN-UHFFFAOYSA-N arginine Natural products OC(=O)C(N)CCCNC(N)=N ODKSFYDXXFIFQN-UHFFFAOYSA-N 0.000 description 3
- TVZPLCNGKSPOJA-UHFFFAOYSA-N copper zinc Chemical compound [Cu].[Zn] TVZPLCNGKSPOJA-UHFFFAOYSA-N 0.000 description 3
- 238000002474 experimental method Methods 0.000 description 3
- 210000000416 exudates and transudate Anatomy 0.000 description 3
- 239000012530 fluid Substances 0.000 description 3
- 230000035876 healing Effects 0.000 description 3
- 239000000017 hydrogel Substances 0.000 description 3
- 230000035699 permeability Effects 0.000 description 3
- 241000894006 Bacteria Species 0.000 description 2
- 241000257465 Echinoidea Species 0.000 description 2
- 241000588724 Escherichia coli Species 0.000 description 2
- FOIXSVOLVBLSDH-UHFFFAOYSA-N Silver ion Chemical compound [Ag+] FOIXSVOLVBLSDH-UHFFFAOYSA-N 0.000 description 2
- 241000191967 Staphylococcus aureus Species 0.000 description 2
- 239000003242 anti bacterial agent Substances 0.000 description 2
- 230000000845 anti-microbial effect Effects 0.000 description 2
- 230000009286 beneficial effect Effects 0.000 description 2
- 239000008187 granular material Substances 0.000 description 2
- 208000015181 infectious disease Diseases 0.000 description 2
- 238000012986 modification Methods 0.000 description 2
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- 208000003322 Coinfection Diseases 0.000 description 1
- 206010048038 Wound infection Diseases 0.000 description 1
- 238000002441 X-ray diffraction Methods 0.000 description 1
- PTFCDOFLOPIGGS-UHFFFAOYSA-N Zinc dication Chemical compound [Zn+2] PTFCDOFLOPIGGS-UHFFFAOYSA-N 0.000 description 1
- 239000000853 adhesive Substances 0.000 description 1
- 230000001070 adhesive effect Effects 0.000 description 1
- 239000004599 antimicrobial Substances 0.000 description 1
- 230000000740 bleeding effect Effects 0.000 description 1
- 239000008280 blood Substances 0.000 description 1
- 210000004369 blood Anatomy 0.000 description 1
- 230000036760 body temperature Effects 0.000 description 1
- 238000006243 chemical reaction Methods 0.000 description 1
- 230000007547 defect Effects 0.000 description 1
- 238000011161 development Methods 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 238000001523 electrospinning Methods 0.000 description 1
- 230000007613 environmental effect Effects 0.000 description 1
- 239000003102 growth factor Substances 0.000 description 1
- 230000002045 lasting effect Effects 0.000 description 1
- 239000002135 nanosheet Substances 0.000 description 1
- 229920000642 polymer Polymers 0.000 description 1
- 239000002994 raw material Substances 0.000 description 1
- 238000011160 research Methods 0.000 description 1
- 230000028327 secretion Effects 0.000 description 1
- GGCZERPQGJTIQP-UHFFFAOYSA-N sodium;9,10-dioxoanthracene-2-sulfonic acid Chemical compound [Na+].C1=CC=C2C(=O)C3=CC(S(=O)(=O)O)=CC=C3C(=O)C2=C1 GGCZERPQGJTIQP-UHFFFAOYSA-N 0.000 description 1
- 238000001228 spectrum Methods 0.000 description 1
- 238000009987 spinning Methods 0.000 description 1
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- 239000002344 surface layer Substances 0.000 description 1
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- 231100000419 toxicity Toxicity 0.000 description 1
- 229920003169 water-soluble polymer Polymers 0.000 description 1
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
- A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
- A61L15/18—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons containing inorganic materials
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F13/00—Bandages or dressings; Absorbent pads
- A61F13/00051—Accessories for dressings
- A61F13/00063—Accessories for dressings comprising medicaments or additives, e.g. odor control, PH control, debriding, antimicrobic
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F13/00—Bandages or dressings; Absorbent pads
- A61F13/02—Adhesive bandages or dressings
- A61F13/0203—Adhesive bandages or dressings with fluid retention members
- A61F13/0206—Adhesive bandages or dressings with fluid retention members with absorbent fibrous layers, e.g. woven or non-woven absorbent pads or island dressings
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
- A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
- A61L15/42—Use of materials characterised by their function or physical properties
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
- A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
- A61L15/42—Use of materials characterised by their function or physical properties
- A61L15/46—Deodorants or malodour counteractants, e.g. to inhibit the formation of ammonia or bacteria
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/10—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing inorganic materials
- A61L2300/102—Metals or metal compounds, e.g. salts such as bicarbonates, carbonates, oxides, zeolites, silicates
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
- A61L2300/404—Biocides, antimicrobial agents, antiseptic agents
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- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/60—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a special physical form
- A61L2300/602—Type of release, e.g. controlled, sustained, slow
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- A61L2400/00—Materials characterised by their function or physical properties
- A61L2400/12—Nanosized materials, e.g. nanofibres, nanoparticles, nanowires, nanotubes; Nanostructured surfaces
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Abstract
The invention relates to the technical field of wound surface coating, in particular to a medical composite antibacterial wound surface coating product which has the advantages of reasonable structure, convenient use, capability of promoting wound healing, broad-spectrum long-acting antibacterial effect, safety, reliability and low price; including medical adhesive tape layer, the layer that absorbs water, antibiotic functional layer and leave type paper layer, it is fixed that the layer that absorbs water passes through medical level hot melt adhesive bonding with antibiotic functional layer to it fixes through the non-setting adhesive layer to absorb water the layer medical adhesive tape layer upper surface to the area on the layer that absorbs water is less than medical adhesive tape layer, it is fixed to bond from type paper layer edge region and medical adhesive tape layer edge region, and from type paper layer central zone and antibiotic functional layer surface contact.
Description
Technical Field
The invention relates to the technical field of wound surface coating, in particular to a medical composite antibacterial wound surface coating product.
Background
As is well known, after a wound surface is produced, usually, a suitable coating product is selected to cover the wound surface sufficiently after a disinfection treatment, and then, the wound surface is fixed by a medical adhesive tape. The coating product has the main functions of protecting the wound surface, absorbing wound tissue fluid and stopping bleeding, thereby promoting the wound surface to heal. However, the traditional coating product does not contain effective antibacterial components, cannot eliminate complications such as wound secondary infection and the like caused by bacteria, and still has defects in the aspect of treating large wound patients such as large-area burns and the like. Meanwhile, although the traditional coating product can absorb wound tissue fluid and blood, thereby being beneficial to wound healing, the surface of the traditional coating product does not contain components for effectively promoting wound healing, and the traditional coating product is mainly repaired and healed by the body, so that the healing period is still longer, and the risk of wound infection is further increased. Therefore, the development of a coating product with antibacterial and wound healing promoting functions has urgent practical requirements.
In view of the above disadvantages, many companies and scientific research institutes have made many studies on the problems of the antibacterial property of the coated product. Korean laid-open patent publication No. 2010-0021108 discloses a silver nanoparticle-containing dressing, which is characterized in that a fiber having silver nanoparticles is prepared by mixing a silver salt with a fiber polymer and then electrospinning, to form a fiber member, and antibacterial effects are achieved by using the silver nanoparticles. Similarly, Xuyin leap et al (patent application No. 201680017038.7) uses water-soluble polymer to release silver by dissolving in water of wound exudate such as tissue fluid, etc. to realize the antibacterial action of dressing. The above two patents both use silver as an antibacterial component, which is relatively high in cost, but silver also has certain biological toxicity and environmental hazard, and is not approved by FDA. Meanwhile, both patents only mention the antibacterial property, and no report on the promotion of wound healing exists.
Patent [201720703863.4] adopts dressing layer containing arginine and hydrogel layer containing nitric oxide synthase as dressing, utilizes the body temperature of wound surface to activate the activity of nitric oxide synthase, catalyzes arginine to produce NO, and the hydrogel layer can rapidly absorb the exudate on the surface of wound after contacting with the wound surface, the absorbed exudate further promotes nitric oxide synthase to catalyze arginine, produce NO, and the pH value near the wound becomes low after reaction, and the created subacid environment promotes the secretion of wound growth factor. And the hydrogel layer can provide a slightly humid healing environment for the wound surface and promote the wound healing. Although the dressing described in the patent mentions antibacterial and wound healing promotion, the dressing needs to be stored at low temperature before use, and the raw material cost is expensive and the practicability is not strong.
Disclosure of Invention
In order to solve the technical problems, the invention provides a medical composite antibacterial wound surface coating product which has a reasonable structure, is convenient to use, can promote wound healing, has a broad-spectrum long-acting antibacterial effect, is safe and reliable, and is low in price.
The invention relates to a medical composite antibacterial wound surface coated product which comprises a medical adhesive tape layer, a water absorption layer, an antibacterial function layer and a release paper layer, wherein the water absorption layer and the antibacterial function layer are fixedly bonded through medical hot melt adhesive, the water absorption layer is fixedly arranged on the upper surface of the medical adhesive tape layer through an adhesive sticker layer, the area of the water absorption layer is smaller than that of the medical adhesive tape layer, the edge area of the release paper layer is fixedly bonded with the edge area of the medical adhesive tape layer, and the central area of the release paper layer is in contact with the surface of the antibacterial function layer.
The medical composite antibacterial wound surface coating product provided by the invention has the advantages that the antibacterial functional layer contains an antibacterial additive, the antibacterial additive is copper-doped zinc oxide nanoparticles, the size of the copper-doped zinc oxide nanoparticles is 20-800 nm, and the copper content is 0.2-20%.
The invention relates to a medical composite antibacterial wound surface coating product, and a preparation method of copper-doped zinc oxide nanoparticles comprises the following steps:
s1, weighing 50-80 parts by weight of copper salt and zinc salt according to the weight ratio of 0.2-20% of copper to zinc, and dissolving in deionized water to obtain a solution A;
s2, weighing 20-50 parts by weight of sodium hydroxide, and dissolving in deionized water to obtain a solution B;
s3, weighing 0.05-5 parts by weight of sodium borohydride, and dissolving the sodium borohydride in deionized water to obtain a solution C;
s4, mixing the solution B obtained from the solution A, S2 obtained from the S1 and the solution C obtained from the S3, and reacting at 60-100 ℃ to obtain a mixed solution D;
and S5, centrifuging the mixed solution D obtained in the step S4 at the speed of 3000-10000 r/min for centrifugal treatment, filtering and cleaning the precipitate obtained by centrifugation, and drying at the temperature of 50-120 ℃ for 6-24 hours to obtain the copper-doped zinc oxide particles.
Compared with the prior art, the invention has the beneficial effects that: the medical composite antibacterial wound surface coated product comprises a coated product such as common gauze and a composite antibacterial additive, wherein the composite antibacterial additive can be added in any link from the spinning of the coated product to a finished product, the dressing is endowed with excellent antibacterial performance mainly by adding copper-zinc composite antibacterial particles on the surface layer of the common coated product, and the existence of zinc ions can promote the rapid healing of the wound surface. The inorganic copper-zinc composite antibacterial agent has lasting antibacterial performance and does not generate drug resistance, and under the premise of ensuring the functions of the traditional coating product, the antibacterial property and the ability of promoting wound healing are endowed, so that the infection of the wound is reduced, the treatment course is shortened, and the inorganic copper-zinc composite antibacterial agent has the advantages of broad-spectrum long-acting antibacterial property, safety, reliability, low price, capability of promoting wound healing, no generation of drug resistance of bacteria and the like.
Drawings
FIG. 1 is a schematic structural view of a medical composite antimicrobial wound dressing article of the present invention;
FIG. 2 is an XRD spectrum of the ZnO-1% Cu nano-antibacterial composite obtained in example 1;
FIG. 3 is an SEM photograph of the ZnO-1% Cu nano antibacterial composite obtained in example 1;
FIG. 4 is an SEM photograph of the ZnO-10% Cu nano antibacterial composite obtained in example 2;
FIG. 5 is an SEM photograph of the ZnO-20% Cu nano antibacterial composite obtained in example 3;
in the drawings, the reference numbers: 1. a medical rubberized fabric layer; 2. a water-absorbing layer; 3. an antimicrobial functional layer; 4. and (7) a release paper layer.
Detailed Description
The following examples are given to further illustrate the embodiments of the present invention. The following examples are intended to illustrate the invention but are not intended to limit the scope of the invention.
Example 1
Aligning a second water absorption layer 2 and a third antibacterial functional layer 3 which have the same shape and size, and bonding the two layers by using medical-grade hot melt adhesive to bond the two layers together; the water absorption layer 2 is formed by compounding high-power water absorption fibers with a nano antibacterial material by methods of spraying, padding, dipping and the like, the antibacterial function layer 3 is formed by compounding a porous PE film with the nano antibacterial material by methods of spraying, padding, dipping and the like, the water absorption layer 2 and the antibacterial function layer 3 are fixed in the middle of the first medical rubberized fabric layer 1 through a non-setting adhesive layer on the first layer (the area of the first layer is larger than that of the second layer and the third layer), and the adhesive layer on the periphery of the first medical rubberized fabric layer 1 is exposed; the periphery of the fourth release paper layer 4 is bonded and fixed with the adhesive layer exposed at the periphery of the first layer, and the middle part of the fourth release paper layer covers the upper surface of the third antibacterial function layer 3. Thus, the four layers of materials are bonded together according to the specification requirement to prepare the multilayer medical dressing which has the advantages of broad-spectrum antibiosis, high moisture absorption, strong air permeability, no drug resistance and convenient use.
The preparation method of the copper-doped zinc oxide nano antibacterial material comprises the following steps:
s1, weighing 65 parts by weight of copper salt and zinc salt according to the weight ratio of 1% of copper to zinc, and dissolving in deionized water to obtain a solution A;
s2, weighing 34.75 parts by weight of sodium hydroxide, and dissolving in deionized water to obtain a solution B;
s3, weighing 0.25 part by weight of sodium borohydride, and dissolving the sodium borohydride in deionized water to obtain a solution C;
s4, reacting the solution B obtained from the solution A, S2 obtained from S1 and the solution C obtained from S3 at 80 ℃ to obtain a mixed solution D;
s5, centrifuging the mixed solution D obtained in the step S4 at 8000 rpm, cleaning the precipitate obtained by centrifugation, and drying at 80 ℃ for 12 hours to obtain copper-doped zinc oxide particles.
The XRD pattern of the finally obtained ZnO-1% Cu nano antibacterial composite material is shown in figure 2, and the average grain size is 23 nm; the SEM photograph is shown in FIG. 3 and is a flower shape composed of nanosheets; the prepared medical nano antibacterial composite dressing shows good antibacterial performance through antibacterial experiments.
Example 2
Aligning a second water absorption layer 2 and a third antibacterial functional layer 3 which have the same shape and size, and bonding the two layers by using medical-grade hot melt adhesive to bond the two layers together; the water absorption layer 2 is formed by compounding high-power water absorption fibers with a nano antibacterial material by methods of spraying, padding, dipping and the like, the antibacterial function layer 3 is formed by compounding a porous PE film with the nano antibacterial material by methods of spraying, padding, dipping and the like, the water absorption layer 2 and the antibacterial function layer 3 are fixed in the middle of the first medical rubberized fabric layer 1 through a non-setting adhesive layer on the first layer (the area of the first layer is larger than that of the second layer and the third layer), and the adhesive layer on the periphery of the first medical rubberized fabric layer 1 is exposed; the periphery of the fourth release paper layer 4 is bonded and fixed with the adhesive layer exposed at the periphery of the first layer, and the middle part of the fourth release paper layer covers the upper surface of the third antibacterial function layer 3. Thus, the four layers of materials are bonded together according to the specification requirement to prepare the multilayer medical dressing which has the advantages of broad-spectrum antibiosis, high moisture absorption, strong air permeability, no drug resistance and convenient use.
The preparation method of the copper-doped zinc oxide nano antibacterial material comprises the following steps:
s1, weighing 64.5 parts by weight of copper salt and zinc salt according to the weight ratio of 10% of copper to zinc, and dissolving in deionized water to obtain a solution A;
s2, weighing 33 parts by weight of sodium hydroxide, and dissolving in deionized water to obtain a solution B;
s3, weighing 2.5 parts by weight of sodium borohydride, and dissolving the sodium borohydride in deionized water to obtain a solution C;
s4, reacting the solution B obtained from the solution A, S2 obtained from S1 and the solution C obtained from S3 at 80 ℃ to obtain a mixed solution D;
s5, centrifuging the mixed solution D obtained in the step S4 at 8000 rpm, cleaning the precipitate obtained by centrifugation, and drying at 80 ℃ for 12 hours to obtain the copper-doped zinc oxide nanoparticles.
The SEM photograph of the ZnO-10% Cu nano antibacterial composite material is shown in FIG. 4, which is a sea urchin structure composed of nano rods; the results of antibacterial experiments show that the content of the granules for the escherichia coli and the staphylococcus aureus is more than 99.99 percent.
Example 3
Aligning a second water absorption layer 2 and a third antibacterial functional layer 3 which have the same shape and size, and bonding the two layers by using medical-grade hot melt adhesive to bond the two layers together; the water absorption layer 2 is formed by compounding high-power water absorption fibers with a nano antibacterial material by methods of spraying, padding, dipping and the like, the antibacterial function layer 3 is formed by compounding a porous PE film with the nano antibacterial material by methods of spraying, padding, dipping and the like, the water absorption layer 2 and the antibacterial function layer 3 are fixed in the middle of the first medical rubberized fabric layer 1 through a non-setting adhesive layer on the first layer (the area of the first layer is larger than that of the second layer and the third layer), and the adhesive layer on the periphery of the first medical rubberized fabric layer 1 is exposed; the periphery of the fourth release paper layer 4 is bonded and fixed with the adhesive layer exposed at the periphery of the first layer, and the middle part of the fourth release paper layer covers the upper surface of the third antibacterial function layer 3. Thus, the four layers of materials are bonded together according to the specification requirement to prepare the multilayer medical dressing which has the advantages of broad-spectrum antibiosis, high moisture absorption, strong air permeability, no drug resistance and convenient use.
The preparation method of the copper-doped zinc oxide antibacterial material comprises the following steps:
s1, weighing 63 parts by weight of copper salt and zinc salt according to the weight ratio of 20% of copper to zinc, and dissolving in deionized water to obtain a solution A;
s2, weighing 32 parts by weight of sodium hydroxide, and dissolving in deionized water to obtain a solution B;
s3, weighing 5 parts by weight of sodium borohydride, and dissolving the sodium borohydride in deionized water to obtain a solution C;
s4, reacting the solution B obtained from the solution A, S2 obtained from S1 and the solution C obtained from S3 at 80 ℃ to obtain a mixed solution D;
s5, centrifuging the mixed solution D obtained in the step S4 at 8000 rpm, cleaning the precipitate obtained by centrifugation, and drying at 80 ℃ for 12 hours to obtain copper-doped zinc oxide particles.
The SEM photograph of the finally obtained ZnO-20% Cu nano antibacterial composite material is shown in FIG. 5, and is a sea urchin structure consisting of nano rods; the results of antibacterial experiments show that the content of the granules for the escherichia coli and the staphylococcus aureus is more than 99.99 percent.
The above description is only a preferred embodiment of the present invention, and it should be noted that, for those skilled in the art, several modifications and variations can be made without departing from the technical principle of the present invention, and these modifications and variations should also be regarded as the protection scope of the present invention.
Claims (3)
1. The utility model provides a medical compound antibiotic surface of a wound cladding goods, its characterized in that, includes medical adhesive tape layer, absorbs water the layer, antibiotic functional layer and leaves the type paper layer, it is fixed through medical level hot melt adhesive bonding with antibiotic functional layer to absorb water the layer and pass through the non-setting adhesive layer to be fixed medical adhesive tape layer upper surface to the area on layer that absorbs water is less than medical adhesive tape layer, it is fixed with medical adhesive tape layer edge region bonding from type paper layer edge region to it contacts with antibiotic functional layer surface from type paper layer central zone.
2. The medical composite antibacterial wound surface covering product of claim 1, wherein the antibacterial functional layer contains an antibacterial additive, the antibacterial additive is copper-doped zinc oxide nanoparticles, the size of the copper-doped zinc oxide nanoparticles is 20-800 nm, and the copper content is 0.2-20%.
3. The medical composite antibacterial wound-surface-coating product of claim 2, wherein the preparation method of the copper-doped zinc oxide nanoparticles comprises the following steps:
s1, weighing 50-80 parts by weight of copper salt and zinc salt according to the weight ratio of 0.2-20% of copper to zinc, and dissolving in deionized water to obtain a solution A;
s2, weighing 20-50 parts by weight of sodium hydroxide, and dissolving in deionized water to obtain a solution B;
s3, weighing 0.05-5 parts by weight of sodium borohydride, and dissolving the sodium borohydride in deionized water to obtain a solution C;
s4, mixing the solution B obtained from the solution A, S2 obtained from the S1 and the solution C obtained from the S3, and reacting at 60-100 ℃ to obtain a mixed solution D;
and S5, centrifuging the mixed solution D obtained in the step S4 at the speed of 3000-10000 r/min for centrifugal treatment, filtering and cleaning the precipitate obtained by centrifugation, and drying at the temperature of 50-120 ℃ for 6-24 hours to obtain the copper-doped zinc oxide particles.
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