CN111077073A - Sample analyzer - Google Patents
Sample analyzer Download PDFInfo
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- CN111077073A CN111077073A CN201811224120.4A CN201811224120A CN111077073A CN 111077073 A CN111077073 A CN 111077073A CN 201811224120 A CN201811224120 A CN 201811224120A CN 111077073 A CN111077073 A CN 111077073A
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/01—Arrangements or apparatus for facilitating the optical investigation
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/86—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving blood coagulating time or factors, or their receptors
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/01—Arrangements or apparatus for facilitating the optical investigation
- G01N2021/0106—General arrangement of respective parts
- G01N2021/0112—Apparatus in one mechanical, optical or electronic block
Abstract
The invention discloses a sample analyzer, comprising: two or three paths of irradiation mechanisms, a three-color light-combining prism and a light splitting mechanism; any path of the irradiation mechanism at least comprises a light source and an optical component, and the optical component enables light beams emitted by the light source to propagate according to a set propagation direction; the three-color light-combining prism is a hexahedral structure formed by connecting four identical right-angle prisms in pairs; the two paths of irradiation mechanisms respectively correspond to two input surfaces of the three-color light-combining prism, or the three paths of irradiation mechanisms respectively correspond to three input surfaces of the three-color light-combining prism; any path of light beam emitted by the irradiation mechanism enters from the input surface of the corresponding three-color light-combining prism and is emitted from the output surface of the three-color light-combining prism; the beam splitting mechanism is used for splitting the light beam emitted from the three-color light-combining prism into at least two sub-beams, and part or all of the at least two sub-beams respectively irradiate corresponding samples.
Description
Technical Field
The invention relates to the technical field of optical detection, in particular to a sample analyzer.
Background
Methods for detecting coagulation events presumably include: coagulation, immunoturbidimetry, and chromogenic substrate methods; the three methods use different wavelengths. In the related art, an optional structure of the hemagglutination meter adopting a multi-wavelength detection method is shown in fig. 1, a wide-spectrum halogen lamp is used as a light source, and time-sharing illumination modulation of light with different wavelengths is realized by rotating a filter disc; however, this structure is limited by the rotation speed of the filter wheel, so that the wavelength switching speed is slow, the halogen lamp has a short life, and the filter wheel and the rotation driving motor of the filter wheel, the halogen lamp and the heat dissipation part thereof have large volumes. In the related art, as shown in fig. 2, in another optional structure of the blood coagulation meter adopting the multi-wavelength detection method, Light Emitting Diodes (LEDs) with multiple wavelengths combine the LEDs by a dichroic mirror corresponding to the LEDs, and realize modulation of Light with different wavelengths by an electronic switching method. However, this structure involves multiple dichroic mirrors, which not only complicates the debugging process, but also is not conducive to the miniaturization of the structure; moreover, since the optical paths of the LEDs of different wavelengths are different, the structure is not easy to shape the optical design of the LEDs.
Disclosure of Invention
In view of the above, it is desirable to provide a sample analyzer with simple and reliable structure.
In order to achieve the above purpose, the technical solution of the embodiment of the present invention is realized as follows:
in a first aspect, an embodiment of the present invention provides a sample analyzer, including: two or three paths of irradiation mechanisms, a three-color light-combining prism and a light splitting mechanism;
any path of the irradiation mechanism at least comprises a light source and an optical component, and the optical component enables light beams emitted by the light source to propagate according to a set propagation direction;
the three-color light-combining prism is a hexahedral structure formed by connecting four identical right-angle prisms in pairs; the two end surfaces of the right-angle prisms are isosceles right triangles, and the right-angle surfaces corresponding to the right-angle sides of two adjacent right-angle prisms are connected in pairs to form the three-color light-combining prism; the three-color light-combining prism comprises two opposite square end surfaces and four rectangular side surfaces, wherein the four rectangular side surfaces are three input surfaces and one output surface respectively, the input surfaces are used for inputting light beams, and the output surfaces are used for outputting the light beams;
the two paths of irradiation mechanisms respectively correspond to two input surfaces of the three-color light-combining prism, or the three paths of irradiation mechanisms respectively correspond to three input surfaces of the three-color light-combining prism; any path of light beam emitted by the irradiation mechanism enters from the input surface of the corresponding three-color light-combining prism and is emitted from the output surface of the three-color light-combining prism;
the beam splitting mechanism is used for splitting the light beam emitted from the three-color light-combining prism into at least two sub-beams, and part or all of the at least two sub-beams respectively irradiate corresponding samples.
In the above scheme, the three input surfaces sequentially include a first input surface, a second input surface and a third input surface;
the wavelength of the light beam emitted by the irradiation mechanism corresponding to the first input surface of the three-color light-combination prism is lambda 1, the wavelength of the light beam emitted by the irradiation mechanism corresponding to the second input surface of the three-color light-combination prism is lambda 2, and the wavelength of the light beam emitted by the irradiation mechanism corresponding to the third input surface of the three-color light-combination prism is lambda 3, wherein lambda 1 is more than lambda 2 and more than lambda 3;
the first right-angle surface of each right-angle prism is plated with a first film, the second right-angle surface of each right-angle prism is plated with a second film, and the right-angle surfaces of two adjacent right-angle prisms plated with the same film are connected in pairs; wherein the first film is totally transmissive to light beams with wavelengths λ 2 and λ 3 and totally reflective to light beams with wavelength λ 1; the second film is totally transmissive to light beams having wavelengths λ 1 and λ 2 and totally reflective to light beams having a wavelength λ 3.
In the above scheme, the optical assembly at least includes a collimating component, and is configured to collimate the light beam emitted by the light source.
In the above aspect, the optical assembly at least includes: and the optical filter is used for filtering the light beams emitted by the light source.
In the foregoing solution, the any one path of the irradiation mechanism includes: at least one dichroic mirror and at least two corresponding sub-illumination mechanisms;
the sub-illumination mechanism at least comprises a sub-light source and a sub-optical assembly, and the sub-optical assembly enables light beams emitted by the sub-light source to propagate according to a set propagation direction;
the dichroic mirror enables the light beams emitted by the at least two sub-irradiation mechanisms to emit to the same direction and enter one input surface of the three-color light-combining prism corresponding to the irradiation mechanism.
In the foregoing solution, the any one path of the irradiation mechanism includes: at least one sub-tristimulus prism and at least two sub-illumination mechanisms;
wherein the sub-irradiation mechanism at least includes: a sub-light source and a sub-optical assembly; the sub-optical assembly enables the light beams emitted by the sub-light sources to be transmitted according to a set transmission direction, and the sub-three-color light-combination prism enables the light beams emitted by the at least two sub-irradiation mechanisms to emit to the same direction and to enter one input surface of the three-color light-combination prism corresponding to the irradiation mechanism.
In the foregoing solution, the any one path of the irradiation mechanism includes: at least one sub-tristimulus prism and at least two sub-illumination mechanisms;
wherein the sub-irradiation mechanism at least includes: a sub-light source and a sub-optical assembly; the sub-optical assembly enables the light beams emitted by the sub-light sources to be transmitted according to a set transmission direction, and the sub-three-color light-combination prism enables the light beams emitted by the at least two sub-irradiation mechanisms to emit to the same direction and to enter one input surface of the three-color light-combination prism corresponding to the irradiation mechanism.
In the above scheme, the light source of the illumination mechanism in any path: the LED light source comprises a Light Emitting Diode (LED) shell, at least two LEDs and an optical filter corresponding to the LEDs;
the LED and the optical filter are arranged in the LED shell; light beams emitted by any one LED are emitted from the LED shell after being filtered by the corresponding optical filter; the at least two LEDs emit light in a time-sharing mode in sequence.
In the above scheme, the three paths of irradiation mechanisms emit light in a time-sharing manner in sequence.
In the above scheme, the sample analyzer further comprises: at least one first optical detector for detecting the sub-beams after illuminating the sample; each of the samples corresponds to one of the first optical detectors.
In the above scheme, the sample analyzer further comprises: a second optical detector for detecting the light source; the at least two sub-beams comprise a first portion and a second portion; each sub-beam of the first portion corresponds to one first optical detector and each sub-beam of the second portion corresponds to one second optical detector.
In the above scheme, the sample analyzer further comprises: a coupling assembly; the coupling component is used for coupling the light beams emitted from the output surface of the three-color light-combination prism to the light splitting mechanism.
In the above scheme, the light splitting mechanism includes a one-to-many optical fiber splitter.
In the sample analyzer provided by the embodiment of the invention, the two-path or three-path irradiation mechanism is used for outputting the combined beam by the three-color light-combining prism, and then the combined beam is divided into at least two sub-beams by the light-splitting mechanism, and the sub-beams irradiate the sample to carry out hemagglutination detection. The sample analyzer provided by the embodiment of the invention has no moving part of the rotary filter disc, so that the sample analyzer has the advantages of more reliable light path, higher wavelength switching speed and simpler structure. The sample analyzer provided by the embodiment of the invention does not need a dichroic mirror and a mechanical structure for bearing the dichroic mirror, and the optical path of each path of irradiation mechanism is the same, so that the sample analyzer has a simple structure and is easy to realize miniaturization.
Drawings
FIG. 1 is a schematic view showing an alternative structure of a hemagglutination meter using a multi-wavelength detection method according to the related art;
FIG. 2 is a schematic view showing an alternative structure of a hemagglutination meter using a multi-wavelength detection method according to the related art;
FIG. 3 is a schematic view of an alternative configuration of a sample analyzer according to an embodiment of the present invention;
fig. 4 is a schematic structural diagram of a three-color light-combining prism according to an embodiment of the present invention;
FIG. 5 is a schematic diagram of an alternative structure of a light source provided in an embodiment of the present invention;
FIG. 6 is a schematic view of another alternative configuration of a sample analyzer provided by an embodiment of the present invention;
fig. 7 is a schematic view of yet another alternative structure of a sample analyzer according to an embodiment of the present invention.
Detailed Description
So that the manner in which the features and aspects of the embodiments of the present invention can be understood in detail, a more particular description of the embodiments of the invention, briefly summarized above, may be had by reference to the embodiments, some of which are illustrated in the appended drawings.
An optional structural schematic diagram of the sample analyzer provided in the embodiment of the present invention, as shown in fig. 3, includes:
two-way or three-way irradiation mechanism, three-color light-combining prism 4 and light-splitting mechanism 6. The sample analyzer may be a blood cell analyzer, a biochemical immunoassay analyzer, a blood coagulation analyzer, a urine analyzer, or other in vitro diagnostic equipment. In the following description, the sample analyzer is mainly exemplified by a coagulation analyzer.
Wherein any one path of the irradiation mechanism at least comprises: a light source and an optical assembly. When the two-path irradiation mechanism is adopted, the light source is any two of the light source 11, the light source 12 and the light source 13; in the case of the three-way illumination mechanism, the light sources are light source 11, light source 12, and light source 13. In some embodiments, the light sources are LED lamps, and the wavelengths corresponding to the light sources 11, 12 and 13 are different. In the embodiment of the invention, the two-way or three-way irradiation mechanism is driven and controlled by the driving device to sequentially emit light in a time-sharing sequence.
The optical assembly may comprise a collimating component, which may be a collimating mirror. As shown in fig. 3, the optical assembly may comprise a collimator lens 2 for propagating the light beam emitted by the light source according to a set propagation direction.
The optical assembly may comprise a filter into which the light beam emitted by the light source enters after passing through the collimator lens 2. The light sources with different wavelengths have different corresponding filters. In the embodiment of the present invention, the light source 11, the light source 12, and the light source 13 correspond to the filter 31, the filter 32, and the filter 33, respectively. The wavelengths of the filter 31, the filter 32 and the filter 33 may be selected to be 405nm, 575nm and 660nm corresponding to different wavelengths.
The three-color light-combination prism 4 is a hexahedral structure formed by connecting four identical right-angle prisms in pairs; the two end surfaces of the right-angle prisms are isosceles right triangles, and the right-angle surfaces corresponding to the right-angle sides of two adjacent right-angle prisms (namely the side surfaces corresponding to the right-angle sides of the right-angle prisms) are connected in pairs to form the three-color light-combining prism; the three-color light-combining prism comprises two opposite square end faces and four rectangular side faces, namely three input faces 41, 42, 43 and one output face 44, wherein the input faces are used for inputting light beams, and the output face 44 is used for outputting the light beams. The side surfaces corresponding to the hypotenuses of the four right-angle prisms respectively form four rectangular side surfaces of the three-color light-combining prism, and one end surfaces of the four right-angle prisms are spliced to form a square end surface of the three-color light-combining prism.
The two paths of irradiation mechanisms respectively correspond to any two input surfaces of the three-color light-combining prism 4, or the three paths of irradiation mechanisms respectively correspond to three input surfaces of the three-color light-combining prism; any one of the light beams emitted by the illumination mechanism enters from the input surface of the corresponding three-color light-combining prism and exits from the output surface 44 of the three-color light-combining prism.
The beam splitting mechanism 6 is configured to split the light beam emitted from the three-color light combining prism 4 into at least two sub-beams, and a part or all of the at least two sub-beams respectively irradiate corresponding samples.
In the embodiment of the present invention, the three input surfaces of the three-color light-combining prism sequentially (as shown in fig. 3, in a counterclockwise direction when viewed from the end surface) include a first input surface 41, a second input surface 42, and a third input surface 43. The wavelength of the light beam emitted by the illumination mechanism (corresponding to the light source 11) corresponding to the first input surface 41 of the three-color light-combining prism is λ 1, the wavelength of the light beam emitted by the illumination mechanism (corresponding to the light source 12) corresponding to the second input surface 42 of the three-color light-combining prism is λ 2, and the wavelength of the light beam emitted by the illumination mechanism (corresponding to the light source 13) corresponding to the third input surface 43 of the three-color light-combining prism is λ 3, wherein λ 1> λ 2> λ 3.
The right-angle surfaces of each right-angle prism comprise a first right-angle surface and a second right-angle surface, the first right-angle surface is plated with a first film, the second right-angle surface is plated with a second film, and the right-angle surfaces of two adjacent right-angle prisms plated with the same film are connected in pairs; wherein the first film is totally transmissive to light beams with wavelengths λ 2 and λ 3 and totally reflective to light beams with wavelength λ 1; the second film is totally transmissive to light beams having wavelengths λ 1 and λ 2 and totally reflective to light beams having a wavelength λ 3. In the exploded view of the three-color light-combining prism 4, as shown in fig. 4, the right-angle surface 51 is coated with a film that is totally transmissive to the light beams with wavelengths λ 2 and λ 3 and totally reflective to the light beam with wavelength λ 1, and the right-angle surface 52 is coated with a film that is totally transmissive to the light beams with wavelengths λ 1 and λ 2 and totally reflective to the light beam with wavelength λ 3.
In some embodiments, the sample analyzer further comprises: at least one first optical detector 8 for detecting the sub-beams after illumination of the sample 7; one for each of the samples 7, the first optical detector 8. The first optical detector 8 may comprise a photodiode for detecting the light beam after illumination of the sample.
The sample analyzer further comprises: a second optical detector 9 for detecting the light source; the sub-beams comprise a first portion and a second portion; each sub-beam of the first portion corresponds to one first optical detector and each sub-beam of the second portion corresponds to one second optical detector. As shown in fig. 3, the second part of the partial beams can have only one partial beam.
Wherein the second optical detector 9 detects the light beam emitted by the light source by detecting the received light beam to monitor the light source fluctuation.
The second optical detector 9 may comprise a photodiode for detecting the light beam emitted by the light source. The functions of the first optical detector 8 and the second optical detector 9 may both be performed by photodiodes.
In an embodiment of the present invention, the sample analyzer further includes: a coupling component 5; the coupling component 5 is used for coupling the light beams emitted from the output surface of the three-color light-combining prism to the light-splitting mechanism 6.
The light splitting mechanism 6 may include a one-to-many optical fiber splitter, the light beam output from the tristimulus prism 4 is coupled to the light splitting mechanism 6 through an optical fiber coupling assembly 5, and the light splitting mechanism 6 splits the light beam into at least two split light beams. Here, the function of the coupling assembly 5 may be realized by a fiber coupling mirror. How many sub-beams the beam is divided into can be determined by the number of samples.
In some embodiments, the light source comprises: the LED light source comprises a light emitting diode LED shell, an LED and an optical filter corresponding to the LED.
In other embodiments, the light source comprises: the LED light source comprises a Light Emitting Diode (LED) shell, at least two LEDs and light filters corresponding to the LEDs, wherein the LEDs and the light filters are arranged in the LED shell. Light beams emitted by any one LED are emitted from the LED shell after being filtered by the corresponding optical filter; the at least two LEDs can emit light in a time-sharing mode sequentially, and the wavelengths of light beams emitted by the LEDs can be different. Thus, the single path irradiation mechanism can combine the light beams emitted by the plurality of LEDs. As shown in fig. 5, the light source includes an LED111, an LED112, and an LED113, and an optical filter 121, an optical filter 122, and an optical filter 123 respectively corresponding to the LED111, the LED112, and the LED113, the LED111, the LED112, and the LED113 may sequentially emit light in a time-sharing manner, and the wavelength of the light beam emitted by the LED111, the wavelength of the light beam emitted by the LED112, and the wavelength of the light beam emitted by the LED113 are different. The volume of the LED housing is as small as possible so that the orientation of the light beams emitted by the individual LEDs within the housing can be considered approximately collinear.
Another schematic diagram of an alternative structure of a sample analyzer according to an embodiment of the present invention is shown in fig. 6, where the structure of the sample analyzer shown in fig. 6 is similar to that of the sample analyzer shown in fig. 3, and a difference is that any one of the paths of the irradiation mechanisms includes: at least one dichroic mirror 10 and corresponding at least two sub-illumination mechanisms; in one embodiment, the sub-illumination mechanism at least comprises a sub-light source 11, a sub-light source 14, a sub-optical assembly 31 and a sub-optical assembly 34, wherein the sub-optical assembly enables light beams emitted by the sub-light source to propagate according to a set propagation direction; the dichroic mirror enables the light beams emitted by the at least two sub-irradiation mechanisms to emit to the same direction and enter one input surface of the three-color light-combining prism corresponding to the irradiation mechanism. Of course, fig. 6 shows only one dichroic mirror and two sub-irradiation mechanisms, in other embodiments, the irradiation mechanism may further include a plurality of dichroic mirrors and a plurality of sub-irradiation mechanisms, for example, 2 dichroic mirrors and 3 sub-irradiation mechanisms, that is, the number of dichroic mirrors and sub-irradiation mechanisms may be expanded in the direction of the sub-light source 11 in fig. 6, and details are not repeated here.
In the sample analyzer shown in fig. 6, only one irradiation mechanism is described, and in a specific implementation, on the basis of fig. 3, a dichroic mirror and a corresponding sub-irradiation mechanism may be added on the basis of any two or even three irradiation mechanisms.
A further alternative structure of the sample analyzer according to the embodiment of the present invention is shown in fig. 7, and the sample analyzer shown in fig. 7 is similar to the sample analyzer shown in fig. 3, except that, on the basis of the sample analyzer shown in fig. 3, any one of the illumination mechanisms may include a sub-tristimulus prism 42 and a sub-illumination mechanism corresponding to the sub-tristimulus prism 42, so as to realize the combination of light beams with more multiple wavelengths. In one embodiment, any one of the irradiation mechanisms includes: at least one sub-tristimulus prism and at least two sub-illumination mechanisms. Wherein the sub-irradiation mechanism at least includes: a sub-light source and a sub-optical assembly. The sub-optical assembly enables the light beams emitted by the sub-light sources to be transmitted according to a set transmission direction and to enter the sub-tristimulus combination prism, and the sub-tristimulus combination prism enables the light beams emitted by the at least two sub-irradiation mechanisms to be emitted to the same direction and to enter one input surface of the tristimulus combination prism corresponding to the irradiation mechanisms. The sub-optical assembly may include filters for filtering and collimating mirrors for collimation. Of course, in fig. 7, only one sub tristimulus prism and three sub irradiation mechanisms are shown, in other embodiments, the irradiation mechanism may further include a plurality of sub tristimulus prisms and a plurality of sub irradiation mechanisms, for example, 2 sub tristimulus prisms and 5 sub irradiation mechanisms, that is, the number of the sub tristimulus prisms and the sub irradiation mechanisms may be expanded in the direction of the sub tristimulus prisms 42 in fig. 7, and details thereof are not repeated.
In the embodiments of the present invention, the three irradiation mechanisms combine the light beams through a three-color light-combining prism, and control different irradiation mechanisms to emit light in a time-sharing manner through the driving circuit, without additionally adding moving components such as a rotary filter disk, etc., so that the light path of the sample analyzer is more reliable, and the switching speed of the light beams with different wavelengths is faster. In the sample analyzer shown in fig. 3 and 7, a dichroic mirror and a mechanical structure for carrying the dichroic mirror are not required, so that the sample analyzer has a simple structure and is easy to realize miniaturization. In addition, in the above embodiments of the present invention, the optical path of each path of the irradiation mechanism is the same, and the installation, debugging and application are simpler.
The blood coagulation analyzer according to any one of the above embodiments, which is used for optically measuring and analyzing the amount of a specific substance related to the blood coagulation/fibrinolysis function and the activity level thereof, wherein the sample is blood plasma. The blood coagulation analyzer of the present embodiment optically measures a sample by a coagulation time method, a chromogenic substrate method, and an immunoturbidimetric method. The coagulation time method used in the present embodiment is a measurement method for detecting the coagulation process of a sample as a change in transmitted light. The measurement items include Prothrombin Time (PT), Activated Partial Thromboplastin Time (APTT), Fibrinogen amount (FIB), and the like. Examples of the measurement items of the chromogenic substrate method include Antithrombin-III (AT-III), and the like, and examples of the measurement items of the immunoturbidimetric method include D-Dimer (D-Dimer) and fibrinogen Degradation Products (FDP, Fibrin (-ogen) Degradation Products), and the like.
The above description is only exemplary of the present invention and should not be taken as limiting the scope of the present invention, and any modifications, equivalents, improvements, etc. that are within the spirit and principle of the present invention should be included in the present invention.
Claims (12)
1. A sample analyzer, comprising: two or three paths of irradiation mechanisms, a three-color light-combining prism and a light splitting mechanism;
any path of the irradiation mechanism at least comprises a light source and an optical component, and the optical component enables light beams emitted by the light source to propagate according to a set propagation direction;
the three-color light-combining prism is a hexahedral structure formed by connecting four identical right-angle prisms in pairs; the two end surfaces of the right-angle prisms are isosceles right triangles, and the right-angle surfaces corresponding to the right-angle sides of two adjacent right-angle prisms are connected in pairs to form the three-color light-combining prism; the three-color light-combining prism comprises two opposite square end surfaces and four rectangular side surfaces, wherein the four rectangular side surfaces are three input surfaces and one output surface respectively, the input surfaces are used for inputting light beams, and the output surfaces are used for outputting the light beams;
the two paths of irradiation mechanisms respectively correspond to two input surfaces of the three-color light-combining prism, or the three paths of irradiation mechanisms respectively correspond to three input surfaces of the three-color light-combining prism; any path of light beam emitted by the irradiation mechanism enters from the input surface of the corresponding three-color light-combining prism and is emitted from the output surface of the three-color light-combining prism;
the beam splitting mechanism is used for splitting the light beam emitted from the three-color light-combining prism into at least two sub-beams, and part or all of the at least two sub-beams respectively irradiate corresponding samples.
2. The sample analyzer of claim 1, wherein: the three input surfaces sequentially comprise a first input surface, a second input surface and a third input surface;
the wavelength of the light beam emitted by the irradiation mechanism corresponding to the first input surface of the three-color light-combination prism is lambda 1, the wavelength of the light beam emitted by the irradiation mechanism corresponding to the second input surface of the three-color light-combination prism is lambda 2, and the wavelength of the light beam emitted by the irradiation mechanism corresponding to the third input surface of the three-color light-combination prism is lambda 3, wherein lambda 1 is more than lambda 2 and more than lambda 3;
the first right-angle surface of each right-angle prism is plated with a first film, the second right-angle surface of each right-angle prism is plated with a second film, and the right-angle surfaces of two adjacent right-angle prisms plated with the same film are connected in pairs; wherein the first film is totally transmissive to light beams with wavelengths λ 2 and λ 3 and totally reflective to light beams with wavelength λ 1; the second film is totally transmissive to light beams having wavelengths λ 1 and λ 2 and totally reflective to light beams having a wavelength λ 3.
3. The sample analyzer of claim 1 wherein the optical assembly includes at least a collimating component for collimating the light beam from the light source.
4. The sample analyzer of any of claims 1 to 3, wherein the optical assembly comprises at least: and the optical filter is used for filtering the light beams emitted by the light source.
5. The sample analyzer of claim 1, wherein the any one of the illumination mechanisms comprises: at least one dichroic mirror and at least two corresponding sub-illumination mechanisms;
the sub-illumination mechanism at least comprises a sub-light source and a sub-optical assembly, and the sub-optical assembly enables light beams emitted by the sub-light source to propagate according to a set propagation direction;
the dichroic mirror enables the light beams emitted by the at least two sub-irradiation mechanisms to emit to the same direction and enter one input surface of the three-color light-combining prism corresponding to the irradiation mechanism.
6. The sample analyzer of claim 1, wherein the any one of the illumination mechanisms comprises: at least one sub-tristimulus prism and at least two sub-illumination mechanisms;
wherein the sub-irradiation mechanism at least includes: a sub-light source and a sub-optical assembly; the sub-optical assembly enables the light beams emitted by the sub-light sources to be transmitted according to a set transmission direction, and the sub-three-color light-combination prism enables the light beams emitted by the at least two sub-irradiation mechanisms to emit to the same direction and to enter one input surface of the three-color light-combination prism corresponding to the irradiation mechanism.
7. The sample analyzer of claim 1, wherein the light source of any of the illumination mechanisms: the LED light source comprises a Light Emitting Diode (LED) shell, at least two LEDs and an optical filter corresponding to the LEDs;
the LED and the optical filter are arranged in the LED shell; light beams emitted by any one LED are emitted from the LED shell after being filtered by the corresponding optical filter; the at least two LEDs emit light in a time-sharing mode in sequence.
8. The sample analyzer of claim 1, wherein the three way illumination mechanism time-divisionally illuminates in sequence.
9. The sample analyzer of claim 1, further comprising: at least one first optical detector for detecting the sub-beams after illuminating the sample; each of the samples corresponds to one of the first optical detectors.
10. The sample analyzer of claim 9, further comprising: a second optical detector for detecting the light source; the sub-beams comprise a first portion and a second portion; each sub-beam of the first portion corresponds to one first optical detector and each sub-beam of the second portion corresponds to one second optical detector.
11. The sample analyzer of claim 1, further comprising: a coupling assembly; the coupling component is used for coupling the light beams emitted from the output surface of the three-color light-combination prism to the light splitting mechanism.
12. The sample analyzer of claim 1, wherein the spectroscopic mechanism includes a one-to-many fiber optic splitter.
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| CN201811224120.4A CN111077073A (en) | 2018-10-19 | 2018-10-19 | Sample analyzer |
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| CN201811224120.4A CN111077073A (en) | 2018-10-19 | 2018-10-19 | Sample analyzer |
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Citations (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6791676B1 (en) * | 1999-10-08 | 2004-09-14 | Dade Behring Marburg Gmbh | Spectrophotometric and nephelometric detection unit |
| US20040263500A1 (en) * | 2003-04-21 | 2004-12-30 | Seiko Epson Corporation | Display device, lighting device and projector |
| CN1613007A (en) * | 2001-11-08 | 2005-05-04 | S.A.E.埃菲金计算机化乳业管理系统 | Spectroscopic fluid analyzer |
| CN1815196A (en) * | 2005-02-03 | 2006-08-09 | 三星电子株式会社 | Multi-channel fluorescence measuring optical system and multi-channel fluorescence sample analyzer |
| JP2006220578A (en) * | 2005-02-14 | 2006-08-24 | Nikon Corp | Surface inspecting apparatus |
| US20060274284A1 (en) * | 2005-05-31 | 2006-12-07 | Infocus Corporation | Illumination arrangements for colored light sources |
| CN101126761A (en) * | 2006-08-18 | 2008-02-20 | 希森美康株式会社 | Blood coagulation analyzer and blood coagulation analyzing method |
| WO2008029337A1 (en) * | 2006-09-07 | 2008-03-13 | Koninklijke Philips Electronics N.V. | Beam combiner for multiple light sources |
| US20080143967A1 (en) * | 2006-12-13 | 2008-06-19 | Philips Lumileds Lighting Company Llc | Multi-Primary LED Projection System |
| CN202270015U (en) * | 2011-09-21 | 2012-06-13 | 深圳市中科康医疗科技有限公司 | Light source used for medical endoscope |
| CN103454192A (en) * | 2003-07-02 | 2013-12-18 | 泰尔茂比司特公司 | Optical cell for extracting optical surface of cell separation chamber in port |
| CN105081560A (en) * | 2014-05-16 | 2015-11-25 | 灿美工程股份有限公司 | Defect observation device and laser processing equipment containing defect observation device |
| CN105492887A (en) * | 2013-03-15 | 2016-04-13 | 理查德·哈理·特纳 | A system and methods for the in vitro detection of particles and soluble chemical entities in body fluids |
| CN105572058A (en) * | 2014-10-09 | 2016-05-11 | 深圳迈瑞生物医疗电子股份有限公司 | Sample analyzer and absorbance measurement device thereof |
| CN107315094A (en) * | 2017-07-27 | 2017-11-03 | 深圳传世生物医疗有限公司 | Blood coagulation analyzer and blood coagulation analyzing method |
| CN107561725A (en) * | 2016-12-07 | 2018-01-09 | 北京数科技有限公司 | Multiplexing apparatus and the mechanical-optical setup for laser three-dimensional projection |
| CN107709989A (en) * | 2015-06-24 | 2018-02-16 | 费森尤斯医疗控股股份有限公司 | Adjustable optical receiver |
-
2018
- 2018-10-19 CN CN201811224120.4A patent/CN111077073A/en active Pending
Patent Citations (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6791676B1 (en) * | 1999-10-08 | 2004-09-14 | Dade Behring Marburg Gmbh | Spectrophotometric and nephelometric detection unit |
| CN1613007A (en) * | 2001-11-08 | 2005-05-04 | S.A.E.埃菲金计算机化乳业管理系统 | Spectroscopic fluid analyzer |
| US20040263500A1 (en) * | 2003-04-21 | 2004-12-30 | Seiko Epson Corporation | Display device, lighting device and projector |
| CN103454192A (en) * | 2003-07-02 | 2013-12-18 | 泰尔茂比司特公司 | Optical cell for extracting optical surface of cell separation chamber in port |
| CN1815196A (en) * | 2005-02-03 | 2006-08-09 | 三星电子株式会社 | Multi-channel fluorescence measuring optical system and multi-channel fluorescence sample analyzer |
| JP2006220578A (en) * | 2005-02-14 | 2006-08-24 | Nikon Corp | Surface inspecting apparatus |
| US20060274284A1 (en) * | 2005-05-31 | 2006-12-07 | Infocus Corporation | Illumination arrangements for colored light sources |
| CN101126761A (en) * | 2006-08-18 | 2008-02-20 | 希森美康株式会社 | Blood coagulation analyzer and blood coagulation analyzing method |
| WO2008029337A1 (en) * | 2006-09-07 | 2008-03-13 | Koninklijke Philips Electronics N.V. | Beam combiner for multiple light sources |
| US20080143967A1 (en) * | 2006-12-13 | 2008-06-19 | Philips Lumileds Lighting Company Llc | Multi-Primary LED Projection System |
| CN202270015U (en) * | 2011-09-21 | 2012-06-13 | 深圳市中科康医疗科技有限公司 | Light source used for medical endoscope |
| CN105492887A (en) * | 2013-03-15 | 2016-04-13 | 理查德·哈理·特纳 | A system and methods for the in vitro detection of particles and soluble chemical entities in body fluids |
| CN105081560A (en) * | 2014-05-16 | 2015-11-25 | 灿美工程股份有限公司 | Defect observation device and laser processing equipment containing defect observation device |
| CN105572058A (en) * | 2014-10-09 | 2016-05-11 | 深圳迈瑞生物医疗电子股份有限公司 | Sample analyzer and absorbance measurement device thereof |
| CN107709989A (en) * | 2015-06-24 | 2018-02-16 | 费森尤斯医疗控股股份有限公司 | Adjustable optical receiver |
| CN107561725A (en) * | 2016-12-07 | 2018-01-09 | 北京数科技有限公司 | Multiplexing apparatus and the mechanical-optical setup for laser three-dimensional projection |
| CN107315094A (en) * | 2017-07-27 | 2017-11-03 | 深圳传世生物医疗有限公司 | Blood coagulation analyzer and blood coagulation analyzing method |
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Application publication date: 20200428 |