CN111035813B - Liquid band-aid type coronary artery membrane stent and manufacturing method thereof - Google Patents

Liquid band-aid type coronary artery membrane stent and manufacturing method thereof Download PDF

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CN111035813B
CN111035813B CN201811198126.9A CN201811198126A CN111035813B CN 111035813 B CN111035813 B CN 111035813B CN 201811198126 A CN201811198126 A CN 201811198126A CN 111035813 B CN111035813 B CN 111035813B
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liquid
aid
liquid band
stent
band
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CN111035813A (en
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姚康
钱菊英
葛雷
吴润达
葛均波
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Zhongshan Hospital Fudan University
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Zhongshan Hospital Fudan University
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L27/507—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials for artificial blood vessels
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/04—Hollow or tubular parts of organs, e.g. bladders, tracheae, bronchi or bile ducts
    • A61F2/06—Blood vessels
    • A61F2/07—Stent-grafts
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/28—Materials for coating prostheses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/28—Materials for coating prostheses
    • A61L27/34—Macromolecular materials
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L27/54—Biologically active materials, e.g. therapeutic substances
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/04—Hollow or tubular parts of organs, e.g. bladders, tracheae, bronchi or bile ducts
    • A61F2/06—Blood vessels
    • A61F2/07—Stent-grafts
    • A61F2002/072—Encapsulated stents, e.g. wire or whole stent embedded in lining
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2240/00—Manufacturing or designing of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof
    • A61F2240/001—Designing or manufacturing processes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
    • A61L2300/416—Anti-neoplastic or anti-proliferative or anti-restenosis or anti-angiogenic agents, e.g. paclitaxel, sirolimus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2420/00—Materials or methods for coatings medical devices
    • A61L2420/06—Coatings containing a mixture of two or more compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2430/00—Materials or treatment for tissue regeneration
    • A61L2430/22—Materials or treatment for tissue regeneration for reconstruction of hollow organs, e.g. bladder, esophagus, urether, uterus

Abstract

The invention discloses a liquid band-aid type coronary artery membrane stent, which comprises a saccule stent and a liquid band-aid adhesive layer coated on the surface of the saccule stent. The coronary artery stent with the membrane has a simple structure, can effectively use the stent with the membrane for plugging treatment in time when coronary perforation occurs, and can improve the clinical work efficiency and the success rate of perforation first aid.

Description

Liquid band-aid type coronary artery membrane stent and manufacturing method thereof
Technical Field
The invention relates to a medical instrument, in particular to a liquid band-aid type coronary artery membrane stent and a manufacturing method thereof.
Background
Coronary artery perforation is a low-incidence (0.1% -3%) but extremely dangerous complication in the Percutaneous Coronary Intervention (PCI) procedure of patients with coronary heart disease, and can cause acute pericardial tamponade and even death of the patients in a short time. Coronary artery perforation is divided into 3 types according to Ellis typing, wherein the I type and the II type have no contrast agent overflow, the incidence rate is low, and the prognosis is good; type III has significant escape of contrast agent from the laceration or pericardial tamponade, with higher incidence and mortality. Therefore, timely and definitive diagnosis and active treatment are the key to first aid of coronary artery perforation. The treatment of type I, type II perforations is mainly closely monitored and observed, wherein type II perforations block the treatment as appropriate, while for type III perforations it is necessary to perform a blocking breach treatment. The currently accepted main methods for blocking coronary artery perforation include balloon intermittent filling and blocking at the perforation site, embolism such as a spring ring or gelatin sponge, stent placement with a membrane, surgery and the like. However, the balloon occlusion increases the risk of thrombosis and death for a long time, the embolism is mainly used for the narrow adaptation syndrome of the far-end small blood vessel, and the trauma is often too serious in the surgical operation, so that the implantation of the stent with the membrane becomes a treatment means with wide adaptation syndrome, simplicity, convenience, practicability and good curative effect in coronary artery perforation.
At present, the membrane-carrying stent used for intracranial blood vessels in the market is mainly of a sandwich-like structure consisting of two layers of stainless steel stents and a layer of polytetrafluoroethylene film in the middle, but has the defects of larger outer diameter, thicker layers, harder texture, poor passing performance and delivery failure in distorted and calcified lesions. At present, the special stent with the membrane for the coronary artery is not available in China, the main reason is that the cost of the stent with the membrane is high, a plurality of manufacturers do not produce the stent with the membrane, and the common stent with the membrane is usually self-made in a catheter room of each hospital due to rare occurrence of coronary artery perforation and cost consideration, so that the closed stent is formed by wrapping the stent with a sterile application membrane, overlapping and placing a plurality of layers of stents, coating a balloon outside the stent and the like. However, the length and the winding strength of the outer-layer wrappage are difficult to master by a self-made stent with a membrane, and the stent is easy to elastically retract due to the covered membrane when being wound too tightly, so that the stent cannot be released in place and unloaded, and a balloon of the stent is easy to stick and is difficult to retract; the self-made membrane-carrying bracket is fragile and lacks stability; the self-made membrane-carrying stent also increases the thickness of the stent, and brings disadvantages for implantation of tortuous lesions and prognosis of patients; in addition, the speed of self-making the stent with the membrane depends on the manufacturing experience of an operator, and the time is often too long; at present, whether 3M adhesive films commonly used by self-made film-carrying stents are placed into a human body to cause obvious rejection reaction is unknown.
Therefore, it is very important to design and prepare the stent with the membrane with thinner layers, high passing degree, good stability, effective release, rapidness, convenience and the like.
Disclosure of Invention
In view of the above-mentioned defects of the prior art, the technical problem to be solved by the present invention is to provide a liquid band-aid type coronary artery stent and a manufacturing method thereof, which can rapidly and simply prepare a film band-aid with stability and a certain toughness, can effectively use the film band-aid to perform plugging treatment in time when coronary perforation occurs, has the advantages of rapid preparation speed, simple steps and good film forming property, and can improve the clinical work efficiency and the success rate of perforation first aid.
The liquid band-aid is applied to the manufacture of the coronary artery band-film stent, and the saccule stent is dipped in the liquid band-aid and then dried to form a layer of film with good attachment and certain toughness, so that the effect of blocking the perforation of the coronary artery can be effectively achieved.
In order to solve the technical problems, the invention provides a liquid band-aid type coronary artery membrane stent which comprises a balloon stent and a liquid band-aid adhesive layer coated on the surface of the balloon stent, wherein the liquid band-aid adhesive layer is formed by quickly drying liquid band-aid liquid and is a breathable, waterproof and elastic film.
Optionally, the liquid adhesive bandage layer comprises a film forming material and a plasticizer, wherein the film forming material is composed of a hydrophilic group and a hydrophobic group, and can quickly form a film with stable texture.
Optionally, the mass ratio of the film forming material to the plasticizer is 100: 1-1: 1, and preferably 10: 1-2: 1.
Optionally, the film-forming material is selected from one or more of nitrocellulose, chitosan, polyvinyl alcohol, polyvinyl acetal and poloxamer, and is preferably chitosan.
Optionally, the plasticizer is selected from one or more of glycerol, castor oil and olive oil, preferably glycerol.
Optionally, the liquid adhesive layer further comprises a bioadhesive material. The biological adhesive material of the invention has the advantages of no toxicity, no absorption, stable performance, good biocompatibility, proper adhesive force and quick action.
Optionally, the bioadhesive material is selected from one or a combination of chitosan, carbomer, cellulose derivatives, preferably carbomer.
Optionally, the liquid adhesive layer of the band-aid further comprises an active substance, and the active substance has bioactivity of resisting vascular intimal hyperplasia.
Optionally, the active substance is selected from one or more of paclitaxel, sirolimus and sirolimus derivatives, preferably, the sirolimus derivatives are selected from everolimus or zotarolimus.
Optionally, the liquid adhesive bandage layer further comprises an anti-intimal hyperplasia drug, so that the stent with the membrane is loaded with the anti-intimal hyperplasia drug at the same time, and a more obvious inhibiting effect on restenosis in the implanted stent can be achieved.
The liquid adhesive bandage layer can be used for carrying medicine, the postoperative influence of restenosis in a stent after implantation is solved, the added active medicine is an optional component, and the specific medicine and content can be selected according to the needs.
The invention also provides a manufacturing method of the liquid band-aid type coronary artery membrane stent, which comprises the following steps:
s1: preparing liquid adhesive bandage glue solution;
s2: dipping the saccule support in liquid woundplast glue solution until the surface of the saccule support is uniformly covered with the liquid woundplast glue solution;
s3: and drying the saccule support, and curing the liquid woundplast glue solution on the surface of the saccule support to form a glue layer to obtain the coronary artery band membrane support.
It should be noted that when the saccule support is immersed in the liquid adhesive bandage liquid, the manner of immersing the saccule support is also very important, and it is preferable that the liquid adhesive bandage liquid is vertically immersed from the head of the saccule support until the saccule support is just immersed in the liquid adhesive bandage liquid. If the balloon is also soaked in the film-forming material, a section of film can be left at the tail end of the stent, and the patency of the blood vessel can be affected. The two ends of the saccule are connected with pipelines with different lengths, and the head of the saccule support is particularly the saccule support connected with one side of the short pipeline.
Optionally, the preparation method of the liquid woundplast glue solution comprises the following steps: weighing the components in the liquid band-aid according to a certain proportion, dissolving the components in a solvent, stirring, and sterilizing to obtain the liquid band-aid glue solution.
Optionally, the solvent is a mixture of a solvent a and a solvent B, the solvent a is selected from ethanol or acetone, the solvent B is selected from n-butyl acetate, n-propyl acetate or ethyl acetate, and preferably, the solvent is a mixture of ethanol and n-butyl acetate.
Optionally, the volume ratio of the solvent A to the solvent B is 1: 2-1: 3.
Compared with the prior art, the technical scheme of the invention has the following beneficial effects:
(1) the formula of the liquid band-aid provided by the technical scheme of the invention can be quickly dried to form a breathable, waterproof and elastic film, has certain plasticity, can avoid the defect of difficult tight attachment caused by irregular wound shape, and can further carry medicine in a glue layer of the liquid band-aid so as to solve the postoperative influence of restenosis in a stent after implantation.
(2) The liquid band-aid layer is coated on the saccule support and then dried to form a film with good adhesion and certain toughness, the obtained coronary artery band-film support has a simple structure, and when coronary perforation occurs, the band-film support can be effectively used for plugging treatment in time, so that the clinical work efficiency and the success rate of perforation first aid can be improved;
(3) the manufacturing method of the coronary artery band membrane stent provided by the invention can be used for quickly and simply preparing the membrane band stent with stability and certain toughness, and is high in manufacturing speed and simple in steps.
The conception, the specific structure and the technical effects of the present invention will be further described with reference to the accompanying drawings to fully understand the objects, the features and the effects of the present invention.
Drawings
FIG. 1 is a schematic structural view of a coronary band stent according to an embodiment of the present invention;
FIG. 2 is a flow chart of the fabrication of a coronary stent according to an embodiment of the present invention;
fig. 3 is a flow chart of a test of a coronary artery stent according to an embodiment of the present invention.
Detailed Description
Reference will now be made in detail to embodiments of the present invention, examples of which are illustrated in the accompanying drawings, wherein like or similar reference numerals refer to the same or similar elements or elements having the same or similar function throughout. The embodiments described below with reference to the drawings are illustrative and intended to be illustrative of the invention and are not to be construed as limiting the invention.
Example 1
Referring to fig. 1, the coronary artery banding film stent of the embodiment of the invention comprises a saccule stent 1 and a liquid adhesive bandage layer. Generally, in the using process, the surface of the balloon 2 is sleeved with the balloon support 1, the liquid adhesive bandage layer is coated on the surface of the balloon support 1, the liquid adhesive bandage layer of the embodiment is formed by quickly drying the liquid adhesive bandage liquid, and the liquid adhesive bandage is a breathable, waterproof and elastic film.
Example 2
Referring to fig. 2, the method for manufacturing the coronary artery stent with the membrane according to the embodiment of the present invention is as follows:
s1: preparing liquid adhesive bandage glue solution;
s2: dipping the saccule support in liquid woundplast glue solution until the surface of the saccule support is uniformly covered with the liquid woundplast glue solution;
s3: and drying the saccule support, and curing the liquid woundplast glue solution on the surface of the saccule support to form a glue layer to obtain the coronary artery band membrane support.
Example 3
The manufacturing method of the coronary artery band membrane stent provided by the embodiment of the invention comprises the following steps:
(1) dissolving 3g of nitrocellulose and 3mL of glycerol in 60mL of ethanol-n-butyl acetate (volume ratio of 1:2), uniformly stirring, and sterilizing to obtain the liquid woundplast glue solution.
(2) Soaking the saccule support in the liquid woundplast glue solution until the surface of the saccule support is uniformly covered with the liquid woundplast glue solution;
(3) and (3) taking out the sacculus bracket, drying and curing the sacculus bracket under an ultraviolet lamp, and forming a glue layer on the surface of the sacculus bracket to obtain the coronary artery band membrane bracket.
Example 4
The manufacturing method of the coronary artery band membrane stent provided by the embodiment of the invention comprises the following steps:
(1) dissolving 6g of nitrocellulose, 1g of sirolimus and 5mL of castor oil in 60mL of ethanol-n-butyl acetate (volume ratio is 1:2), uniformly stirring, and sterilizing to obtain the liquid woundplast glue solution.
(2) Soaking the saccule support in the liquid woundplast glue solution until the surface of the saccule support is uniformly covered with the liquid woundplast glue solution;
(3) and (3) taking out the sacculus bracket, drying and curing the sacculus bracket under an ultraviolet lamp, and forming a glue layer on the surface of the sacculus bracket to obtain the coronary artery band membrane bracket.
Examples 5 to 9
The manufacturing methods of the coronary artery band membrane stents of examples 5 to 9 are different from those of examples 3 and 4 only in the formula of the liquid woundplast liquid, and the formula of the liquid woundplast liquid of examples 5 to 9 is shown in table 1.
TABLE 1 liquid Woundplast glue solution formula
Figure BDA0001829332220000051
Example 10
The formulation of example 5 (formulation five) was tested in conjunction with figure 3, as follows:
(1) vertically immersing two common saccule supports into the formula V from the head of the saccule support, waiting for 2-3 minutes until the saccule support is just immersed into the glue solution, and taking out the saccule support to obtain a liquid band-aid type coronary artery band membrane support for later use;
(2) the miniature pig is punctured through femoral artery access and is placed into a guide catheter, a guide wire is placed in the left anterior descending branch, the miniature pig is sent into a pre-expansion balloon through the guide wire, after the miniature pig is expanded for 10-20 seconds by blasting pressure, obvious contrast agent seeps out of a coronary artery perforation, a liquid adhesive bandage type coronary artery membrane stent which is successfully prepared before is sent immediately at the moment, the contrast is rechecked after the miniature pig is expanded and released for 5-10 seconds by the named pressure, and whether the contrast agent seeps out or not is observed, wherein the step is not shown in the figure;
(3) continuing to refer to fig. 3, drying another liquid woundplast type coronary artery banding membrane stent under ultraviolet lamp for 1-2 minutes, and stretching the stent surface membrane with ophthalmologic forceps at a certain force to test its membrane forming characteristics.
Examples 11 to 14
The test methods of examples 11-14 are the same as in example 10 except that the formulation of example 5 was sequentially replaced with the formulations of examples 6, 7, 8, and 9, and the test results are shown in Table 2.
TABLE 2 results of the experiment
Examples Formulation of Film Forming Properties Review radiography
10 Example 5 Toughness and ductility Does not bleed out
11 Example 6 Toughness and ductility Does not bleed out
12 Example 7 Toughness and ductility Does not bleed out
13 Example 8 Toughness and ductility Does not bleed out
14 Example 9 Toughness and ductility Does not bleed out
As can be seen from Table 2, the formulations of examples 5-9 applied to the surface of the stent resulted in a stent with certain toughness and ductility, and the stent with membrane effectively blocked type III coronary perforation.
The foregoing detailed description of the preferred embodiments of the invention has been presented. It should be understood that numerous modifications and variations could be devised by those skilled in the art in light of the present teachings without departing from the inventive concepts. Therefore, the technical solutions available to those skilled in the art through logic analysis, reasoning and limited experiments based on the prior art according to the concept of the present invention should be within the scope of protection defined by the claims.

Claims (12)

1. The liquid band-aid type coronary artery stent is characterized by comprising a saccule stent and a liquid band-aid adhesive layer coated on the surface of the saccule stent, wherein the liquid band-aid adhesive layer comprises a film forming material and a plasticizer, and the film forming material is selected from one or more of nitrocellulose, chitosan, polyvinyl alcohol, polyvinyl acetal and poloxamer.
2. The liquid band-aid type coronary artery stent according to claim 1, wherein the mass ratio of the film forming material to the plasticizer is 100: 1-1: 1.
3. The liquid band-aid coronary stent according to claim 1, wherein the plasticizer is selected from one or more of glycerin, castor oil and olive oil.
4. The liquid band-aid coronary stent according to claim 1, wherein the liquid band-aid adhesive layer further comprises a bioadhesive material.
5. The liquid band-aid type coronary stent according to claim 4, wherein the bioadhesive material is selected from one of or a combination of chitosan, carbomer, cellulose derivatives.
6. The liquid band-aid type coronary stent according to claim 1, wherein the liquid band-aid adhesive layer further comprises an active substance, and the active substance has bioactivity for resisting vascular intimal hyperplasia.
7. The liquid band-aid coronary stent according to claim 6, wherein the active substance is selected from one or more of paclitaxel, sirolimus and derivatives thereof.
8. The liquid band-aid type coronary stent according to claim 2, wherein the liquid band-aid adhesive layer further comprises an anti-intimal hyperplasia drug.
9. A method for manufacturing the liquid band-aid type coronary artery stent as claimed in any one of claims 1 to 8, characterized by comprising the following steps:
s1: preparing liquid adhesive bandage glue solution;
s2: dipping the saccule support in liquid woundplast glue solution until the surface of the saccule support is uniformly covered with the liquid woundplast glue solution;
s3: and drying the saccule support, and curing the liquid woundplast glue solution on the surface of the saccule support to form a glue layer to obtain the coronary artery band membrane support.
10. The method for manufacturing the liquid band-aid type coronary artery stent according to claim 9, wherein the liquid band-aid glue solution is prepared by the following steps: weighing the components according to a certain proportion, dissolving the components in a solvent, stirring and sterilizing to obtain the liquid woundplast glue solution.
11. The method for manufacturing the liquid band-aid type coronary artery stent according to claim 10, wherein the solvent is a mixture of a solvent A and a solvent B, the solvent A is selected from ethanol or acetone, and the solvent B is selected from n-butyl acetate, n-propyl acetate or ethyl acetate.
12. The method for manufacturing the liquid band-aid type coronary artery stent according to claim 11, wherein the volume ratio of the solvent A to the solvent B is 1: 2-1: 3.
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Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1465410A (en) * 2002-06-27 2004-01-07 微创医疗器械(上海)有限公司 Drug-eluting stent (DES) with multicoating
WO2004112863A1 (en) * 2003-06-20 2004-12-29 Mcgill University Biodegradable membrane-covered implant comprising chitosan
CN102078229A (en) * 2010-12-21 2011-06-01 苏州同科生物材料有限公司 Degradable coronary artery scaffold and preparation method thereof
DE202015006492U1 (en) * 2015-09-21 2015-10-23 Lothar Sellin Natural resin cladding
CN105228664A (en) * 2013-03-15 2016-01-06 雅培心血管系统有限公司 For the tissue adherence coating of medicinal balloon
CN106821564A (en) * 2016-12-29 2017-06-13 凯斯蒂南京医疗器械有限公司 A kind of dual balloon catheter support

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4634395A (en) * 1984-03-22 1987-01-06 Donald Burchett Inflatable elastomeric balloons having increased buoyant lifetimes
CN1209105C (en) * 2002-01-04 2005-07-06 中国科学院化学研究所 Coronary artery skeleton medicinal coating for preventing restenosis of blood vessel
US8980300B2 (en) * 2004-08-05 2015-03-17 Advanced Cardiovascular Systems, Inc. Plasticizers for coating compositions
BR112013033810A2 (en) * 2011-06-30 2017-02-14 Elixir Medical Corp biodegradable stent graft and methods for its manufacture
CN102940543A (en) * 2012-09-25 2013-02-27 苏州爱瑞德医疗科技有限公司 Combined medical instrument formed by drug coated balloon and stent
RU2745065C2 (en) * 2015-06-15 2021-03-18 ЭнЭмДи ФАРМА A/C Compounds used for the treatment of neuromuscular disorders
CN106937895B (en) * 2016-01-05 2020-12-18 上海微创医疗器械（集团）有限公司 Covered stent and preparation method thereof
CN108261569B (en) * 2016-12-31 2021-01-22 先健科技(深圳)有限公司 Preparation method of medicine balloon
CN108158701A (en) * 2018-02-09 2018-06-15 天津市胸科医院 For treating the biological absorbable membrane part overlay film frame of bifurcated lesions coronary artery perforation

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1465410A (en) * 2002-06-27 2004-01-07 微创医疗器械(上海)有限公司 Drug-eluting stent (DES) with multicoating
WO2004112863A1 (en) * 2003-06-20 2004-12-29 Mcgill University Biodegradable membrane-covered implant comprising chitosan
CN102078229A (en) * 2010-12-21 2011-06-01 苏州同科生物材料有限公司 Degradable coronary artery scaffold and preparation method thereof
CN105228664A (en) * 2013-03-15 2016-01-06 雅培心血管系统有限公司 For the tissue adherence coating of medicinal balloon
DE202015006492U1 (en) * 2015-09-21 2015-10-23 Lothar Sellin Natural resin cladding
CN106821564A (en) * 2016-12-29 2017-06-13 凯斯蒂南京医疗器械有限公司 A kind of dual balloon catheter support

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
金属支架蛋白涂层介导的血管内局部转基因;袁晋青等;《中国循环杂志》;19971024(第05期);第330-333页 *

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