CN111035792A - Bergenin electrospun membrane callus medical dressing and preparation method and application thereof - Google Patents
Bergenin electrospun membrane callus medical dressing and preparation method and application thereof Download PDFInfo
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- CN111035792A CN111035792A CN201911285973.3A CN201911285973A CN111035792A CN 111035792 A CN111035792 A CN 111035792A CN 201911285973 A CN201911285973 A CN 201911285973A CN 111035792 A CN111035792 A CN 111035792A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
- A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
- A61L15/22—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons containing macromolecular materials
- A61L15/26—Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds; Derivatives thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
- A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
- A61L15/20—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons containing organic materials
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
- A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
- A61L15/22—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons containing macromolecular materials
- A61L15/24—Macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds; Derivatives thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
- A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
- A61L15/42—Use of materials characterised by their function or physical properties
- A61L15/44—Medicaments
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- D—TEXTILES; PAPER
- D01—NATURAL OR MAN-MADE THREADS OR FIBRES; SPINNING
- D01D—MECHANICAL METHODS OR APPARATUS IN THE MANUFACTURE OF ARTIFICIAL FILAMENTS, THREADS, FIBRES, BRISTLES OR RIBBONS
- D01D5/00—Formation of filaments, threads, or the like
- D01D5/0007—Electro-spinning
- D01D5/0015—Electro-spinning characterised by the initial state of the material
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- D—TEXTILES; PAPER
- D04—BRAIDING; LACE-MAKING; KNITTING; TRIMMINGS; NON-WOVEN FABRICS
- D04H—MAKING TEXTILE FABRICS, e.g. FROM FIBRES OR FILAMENTARY MATERIAL; FABRICS MADE BY SUCH PROCESSES OR APPARATUS, e.g. FELTS, NON-WOVEN FABRICS; COTTON-WOOL; WADDING ; NON-WOVEN FABRICS FROM STAPLE FIBRES, FILAMENTS OR YARNS, BONDED WITH AT LEAST ONE WEB-LIKE MATERIAL DURING THEIR CONSOLIDATION
- D04H1/00—Non-woven fabrics formed wholly or mainly of staple fibres or like relatively short fibres
- D04H1/70—Non-woven fabrics formed wholly or mainly of staple fibres or like relatively short fibres characterised by the method of forming fleeces or layers, e.g. reorientation of fibres
- D04H1/72—Non-woven fabrics formed wholly or mainly of staple fibres or like relatively short fibres characterised by the method of forming fleeces or layers, e.g. reorientation of fibres the fibres being randomly arranged
- D04H1/728—Non-woven fabrics formed wholly or mainly of staple fibres or like relatively short fibres characterised by the method of forming fleeces or layers, e.g. reorientation of fibres the fibres being randomly arranged by electro-spinning
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/20—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing organic materials
- A61L2300/216—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing organic materials with other specific functional groups, e.g. aldehydes, ketones, phenols, quaternary phosphonium groups
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
- A61L2300/412—Tissue-regenerating or healing or proliferative agents
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- General Health & Medical Sciences (AREA)
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- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
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Abstract
The invention provides a bergenin electrospun membrane medical dressing as well as a preparation method and application thereof, belonging to the technical field of medical materials. The medical dressing comprises the following specific preparation steps: adding high molecular polymer and bergenin into alcohol to prepare an electrospinning solution; magnetically stirring the prepared electrospinning solution at a set temperature to obtain a uniformly dispersed electrospinning solution; and then, according to the set process conditions, carrying out electrostatic spinning on the electrospinning solution on electrostatic spinning equipment to obtain the bergenin electrospun membrane medical dressing. The bergenin electrospun membrane medical dressing is prepared by combining bergenin and electrostatic spinning, and compared with the common electrostatic spinning medical dressing without bergenin, the medical dressing can obviously improve the healing speed and healing effect of wounds and has important significance for promoting the healing of the wounds of patients and relieving the pain of the patients.
Description
Technical Field
The invention belongs to the technical field of medical materials, and particularly relates to a bergenin electrospun membrane medical dressing as well as a preparation method and application thereof.
Background
In daily life of people, skin is often damaged due to conditions of scraping, collision, knife wound, puncture and the like, the skin damage can not only bring pain to patients, but also bacterial infection and suppuration are very easy to occur after the skin damage. Therefore, it is important for the patient to select a suitable medical dressing to prevent bacterial infection of the wound.
At present, the conventional dressing in common use mainly comprises: gauze, bandage, absorbent cotton, etc., these traditional dressings hemostatic effect and permeability are relatively poor, use inconvenient, and the healing speed of wound is longer after using.
Electrospinning is a simple and versatile technique that produces scaffolds formed of nanofibers and microfibers, is a good drug carrier, and can also provide a favorable microenvironment for cell development by mimicking the natural extracellular matrix. In the field of medicine, the medical dressing prepared by electrostatic spinning has the advantages of good air permeability and being beneficial to wound repair and healing, and is widely concerned at present.
These advantages provide a good environment for wound repair and healing and are therefore of widespread interest.
Bergenin (Bm) is an isocoumarin compound obtained by separating Bergenin monohydrate from bergenia plant of Saxifragaceae; the molecular formula is C14H16O9Molecular weight of 328.27, CAS No.477-90-7, and structural formula as follows:
rhizoma Seu herba Bergeniae has antipyretic, analgesic, antitussive, expectorant, antiinflammatory, kidney protecting, antidiabetic, HIV resisting and anticoagulant effects. Until now, the application of bergenin to medical dressings to promote skin healing has not been studied. Therefore, the medical dressing with good wound healing effect is prepared by combining bergenin and electrostatic spinning.
Disclosure of Invention
The invention aims to provide a novel medical dressing which has good healing effect, high healing speed and no toxic or side effect.
In order to achieve the purpose, the invention provides the following technical scheme:
a preparation method of bergenin electrospun membrane medical dressing comprises the following steps:
step 1: preparation of electrospinning solution
(1) Adding high molecular polymer and bergenin into alcohol to prepare an electrospinning solution;
(2) magnetically stirring the electrospinning solution at a set temperature to obtain a uniformly dispersed electrospinning solution;
step 2: electrostatic spinning
(1) And according to the set process conditions, performing electrostatic spinning on the electrospinning solution on electrostatic spinning equipment to obtain the bergenin electrospun membrane medical dressing.
Preferably, the high molecular polymer is one of polycaprolactone, polyvinyl alcohol, polyoxyethylene and polyimide; the alcohol is one of methanol, ethanol and trifluoroethanol.
Preferably, in the step 1(1), the weight ratio of bergenin: the ratio of the high molecular polymer is 1-2: 10.
Preferably, the concentration of the electrospinning solution in the step 1(1) is 10-15%.
Preferably, the temperature set in step 1(2) is 30-50 ℃.
Preferably, the time of the magnetic stirring in the step 1(2) is 1-2 hours, and the speed of the magnetic stirring is 500-.
Preferably, the parameters set in step 2(1) are as follows: the voltage difference between the positive voltage and the negative voltage is 10-20kv, the distance between the electrospinning spray head and the electrospinning receiving plate is 15-25cm, the electrospinning temperature is 25-35 ℃, the electrospinning humidity is 30-40%, and the electrospinning time is 1-2 h.
Secondly, the invention provides a bergenin electrospun membrane medical dressing which is prepared by the preparation method.
Preferably, the medical dressing has a thickness of 0.5-1mm and a size of 1 x 1-2 x 2cm.
In addition, the invention provides application of the bergenin electrospun membrane medical dressing, and the medical dressing is directly attached to a wound after being sterilized by ultraviolet irradiation for 1-2 hours and is used for promoting wound healing.
The invention has the beneficial effects that:
the bergenin electrospun membrane medical dressing is prepared by combining bergenin and electrostatic spinning, and compared with the common electrostatic spinning medical dressing without bergenin, the medical dressing can obviously improve the healing speed and healing effect of the wound and has important significance for promoting the healing of the wound of a patient and relieving the pain of the patient.
Drawings
FIG. 1 shows the effect of bergenin electrospun membrane dressing on wounds of Wistar rats.
FIG. 2 is a graph of the effect of bergenin electrospun membrane dressing on inflammatory cytokine secretion in Wistar rat wound tissue.
FIG. 3 shows the effect of bergenin electrospun membrane dressing on rat wound histopathology.
Detailed Description
In order to clearly illustrate the technical features of the present solution, the present solution is explained below by way of specific embodiments.
Example 1
1. Adding polycaprolactone and bergenin into trifluoroethanol to prepare 10% of electrospinning solution, wherein the mass of the bergenin in the solution is 5% of that of the polycaprolactone.
2. The electrospinning solution is stirred for 1h at the temperature of 30 ℃ and at the speed of 500r/min, and the uniformly dispersed electrospinning solution is obtained.
3. According to the set process conditions, on an electrostatic spinning device, electrostatic spinning is carried out on the mixed electrospinning solution to obtain the bergenin electrospun membrane medical dressing 1, the bergenin electrospun membrane medical dressing 1 is cut into pieces with the thickness of 0.5mm and the size of 1 x 1cm, and the bergenin electrospun membrane medical dressing can be used after being irradiated for 1 hour by ultraviolet light. The industrial conditions are as follows: the voltage difference between the positive voltage and the negative voltage is 12kv, the distance between the spray head and the receiving plate is 15cm, the electrospinning temperature is 25 ℃, the electrospinning humidity is 30%, and the electrospinning time is 2 h.
Example 2
1. Adding polyimide and bergenin into trifluoroethanol to prepare 12.5% of electrospinning solution, wherein the mass of the bergenin in the solution is 8% of that of the polyimide.
Stirring for 2h at the temperature of 2.50 ℃ and the speed of 1000r/min to obtain a uniformly dispersed mixed electrospinning solution.
3. On electrostatic spinning equipment, according to set process conditions, electrostatic spinning is carried out on the mixed electrospinning solution to obtain the bergenin electrospun membrane medical dressing 2, the bergenin electrospun membrane medical dressing is cut into the shape with the thickness of 1mm and the size of 2 x 2cm, and the bergenin electrospun membrane medical dressing can be used after being irradiated by ultraviolet for 2 hours. The industrial conditions are as follows: the voltage difference between the positive voltage and the negative voltage is 20kv, the distance between the spray head and the receiving plate is 25cm, the electrospinning temperature is 35 ℃, the electrospinning humidity is 40%, and the electrospinning time is 0.5 h.
Example 3
1. Adding polyvinyl alcohol and bergenin into methanol to prepare 15% of electrospinning solution, wherein the mass of the bergenin in the solution is 10% of that of the polyvinyl alcohol.
Stirring for 2h at the temperature of 2.50 ℃ and the speed of 1000r/min to obtain a uniformly dispersed mixed electrospinning solution.
3. On electrostatic spinning equipment, according to set process conditions, electrostatic spinning is carried out on the mixed electrospinning solution to obtain the bergenin electrospun membrane medical dressing 3, the bergenin electrospun membrane medical dressing is cut into the shape with the thickness of 0.5mm and the size of 1 x 1cm, and the bergenin electrospun membrane medical dressing can be used after being irradiated for 1 hour by ultraviolet light. The industrial conditions are as follows: the voltage difference between the positive voltage and the negative voltage is 20kv, the distance between the spray head and the receiving plate is 25cm, the electrospinning temperature is 35 ℃, the electrospinning humidity is 40%, and the electrospinning time is 1 h.
Example 4
1. Adding polyoxyethylene and bergenin into ethanol to prepare 15% of electrospinning solution, wherein the mass of the bergenin in the solution is 10% of that of the polyoxyethylene.
Stirring for 2h at the temperature of 2.50 ℃ and the speed of 1000r/min to obtain a uniformly dispersed mixed electrospinning solution.
3. On electrostatic spinning equipment, according to set process conditions, electrostatic spinning is carried out on the mixed electrospinning solution to obtain the bergenin electrospun membrane medical dressing 4, the bergenin electrospun membrane medical dressing is cut into the shape with the thickness of 1mm and the size of 2 x 2cm, and the bergenin electrospun membrane medical dressing can be used after being irradiated for 1h by ultraviolet. The industrial conditions are as follows: the voltage difference between the positive voltage and the negative voltage is 20kv, the distance between the spray head and the receiving plate is 25cm, the electrospinning temperature is 35 ℃, the humidity is 40%, and the electrospinning time is 2 h.
Experimental methods
1. Callus effect detection
Wistar rats, 8% sodium sulfide, were dehaired on the back (or shaved with a razor), washed in warm water and caged. Water is forbidden before and after the operation, 10% chloral hydrate (300mg/kg) is subjected to intraperitoneal injection for anesthesia on the day of the operation, and four square wound surfaces with left and right symmetrical areas of 1cm multiplied by 1cm are designed by taking the dorsal spine of a rat as a midline. After 75% alcohol disinfection, the skin and the superficial fascia are completely removed according to the design until the superficial surface of the deep fascia, and the bleeding is completely stopped.
Dividing mice into control group, model group, bergenin group
Control group (Control): the wound is not treated at all
Model group (Model): common electrospinning medical dressing treatment wound
Bergenin group (Bm): bergenin electrospun membrane medical dressing
The wounds of the rats were treated according to the corresponding groups. Rats were observed for window healing within 3,5,7,9, 11 days after dosing. At two time points of 5 days and 11 days respectively, 10% chloral hydrate is used for intraperitoneal injection anesthesia, and the wound surface whole skin is carefully removed.
2, detecting the content of TNF- α, IL-10, IL-1 β and mmp9
At two time points of 5 days and 11 days respectively, 10% chloral hydrate is used for intraperitoneal injection anesthesia, the whole skin of the wound surface is carefully taken down, then the wound healing tissue is prepared into tissue homogenate suspension, the tissue homogenate suspension is centrifuged (3600 r/min, 10min), homogenate supernatant is collected and diluted ten times, and the contents of TNF- α, IL-10, IL-1 β and mmp9 are detected according to the specification of an ELISA detection kit, and the result is shown in figure 2.
3. Pathological detection of wound healing tissue
The collected wound healing tissues at the two time points of 5 and 11 days were put into a pre-prepared fixative, and the wound healing tissues were fabricated into pathological tissue sections by immunohistochemistry, the results of which are shown in fig. 3.
Results of the experiment
1. Callus effect test results
As can be seen from fig. 1, the wounds of the rats of the bergenin group healed faster and more effectively than those of the control group and the model group.
2, detecting the contents of TNF- α, IL-10, IL-1 β and mmp9
As can be seen from FIG. 2, the contents of inflammatory factors TNF- α, IL-1 β and mmp9 were significantly reduced and the content of inflammatory factor IL-10 was significantly increased in the bergenin group compared to the control group and the model group.
3. Pathological detection result of wound healing tissue
As can be seen from the HE results of FIG. 3, the growth of the macroscopic tissues of the bergenia group was faster and better in the same time compared to the control group.
In conclusion, compared with the control group and the model group, the medical dressing of the bergenia purpurascens group has better healing effect and healing speed on the wounds of rats.
Claims (10)
1. A preparation method of bergenin electrospun membrane medical dressing is characterized by comprising the following steps:
step 1: preparation of electrospinning solution
(1) Adding high molecular polymer and bergenin into alcohol to prepare an electrospinning solution;
(2) magnetically stirring the electrospinning solution at a set temperature to obtain a uniformly dispersed electrospinning solution;
step 2: electrostatic spinning
(1) And according to the set process conditions, performing electrostatic spinning on the electrospinning solution on electrostatic spinning equipment to obtain the bergenin electrospun membrane medical dressing.
2. The preparation method according to claim 1, wherein the high molecular polymer is one of polycaprolactone, polyvinyl alcohol, polyoxyethylene, and polyimide; the alcohol is one of methanol, ethanol and trifluoroethanol.
3. The method according to claim 1, wherein in step 1(1), the ratio of bergenin: the ratio of the high molecular polymer is 1-2: 10.
4. The method according to claim 1, wherein the concentration of the electrospinning solution in step 1(1) is 10 to 15%.
5. The method according to claim 1, wherein the temperature set in step 1(2) is 30 to 50 ℃.
6. The method as claimed in claim 1, wherein the magnetic stirring time in step 1(2) is 1-2 hours, and the magnetic stirring speed is 500-1000 r/min.
7. The method according to claim 1, wherein the parameters set in step 2(1) are: the voltage difference between the positive voltage and the negative voltage is 10-20kv, the distance between the electrospinning spray head and the electrospinning receiving plate is 15-25cm, the electrospinning temperature is 25-35 ℃, the electrospinning humidity is 30-40%, and the electrospinning time is 1-2 h.
8. A bergenin electrospun film medical dressing prepared by the preparation method of any one of claims 1 to 6.
9. The medical dressing of claim 8, wherein the medical dressing has a thickness of 0.5-1mm and a size of 1 x 1-2 x 2cm.
10. The application of the bergenin electrospun membrane medical dressing is characterized in that the medical dressing is directly attached to a wound after being irradiated by ultraviolet for 1-2 hours to promote wound healing.
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| CN201911285973.3A CN111035792A (en) | 2019-12-13 | 2019-12-13 | Bergenin electrospun membrane callus medical dressing and preparation method and application thereof |
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| CN201911285973.3A CN111035792A (en) | 2019-12-13 | 2019-12-13 | Bergenin electrospun membrane callus medical dressing and preparation method and application thereof |
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Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108392669A (en) * | 2018-03-01 | 2018-08-14 | 澳门大学 | A kind of bioactive polysaccharide dressing and its preparation method and application for wound repair |
| CN110101897A (en) * | 2019-04-19 | 2019-08-09 | 青岛大学 | A kind of method that burn and scald skin is nursed in situ |
| CN110124094A (en) * | 2019-04-19 | 2019-08-16 | 青岛大学 | A kind of Chinese herbal medicine based micro-nano fibre antibacterial dressing be prepared in situ and application method |
| WO2019193053A1 (en) * | 2018-04-04 | 2019-10-10 | Universidad Del Pais Vasco/ Euskal Herriko Unibertsitatea (Upv/Ehu) | Electrospun fibers of biocompatible polymers suitable for tissue scaffolds |
| CN110538198A (en) * | 2019-08-30 | 2019-12-06 | 广东海洋大学 | application of Sipunculus nudus water extract in wound repair |
-
2019
- 2019-12-13 CN CN201911285973.3A patent/CN111035792A/en active Pending
Patent Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108392669A (en) * | 2018-03-01 | 2018-08-14 | 澳门大学 | A kind of bioactive polysaccharide dressing and its preparation method and application for wound repair |
| WO2019193053A1 (en) * | 2018-04-04 | 2019-10-10 | Universidad Del Pais Vasco/ Euskal Herriko Unibertsitatea (Upv/Ehu) | Electrospun fibers of biocompatible polymers suitable for tissue scaffolds |
| CN110101897A (en) * | 2019-04-19 | 2019-08-09 | 青岛大学 | A kind of method that burn and scald skin is nursed in situ |
| CN110124094A (en) * | 2019-04-19 | 2019-08-16 | 青岛大学 | A kind of Chinese herbal medicine based micro-nano fibre antibacterial dressing be prepared in situ and application method |
| CN110538198A (en) * | 2019-08-30 | 2019-12-06 | 广东海洋大学 | application of Sipunculus nudus water extract in wound repair |
Non-Patent Citations (2)
| Title |
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| 国家药典委员会: "《中华人民共和国药典临床用药须知 中药饮片卷 2015年版》", 31 October 2017, 中国医药科技出版社 * |
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Application publication date: 20200421 |