CN111013014A - Nerve tissue stimulation composite material, composite membrane and nerve tissue prosthesis - Google Patents
Nerve tissue stimulation composite material, composite membrane and nerve tissue prosthesis Download PDFInfo
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- CN111013014A CN111013014A CN201911307183.0A CN201911307183A CN111013014A CN 111013014 A CN111013014 A CN 111013014A CN 201911307183 A CN201911307183 A CN 201911307183A CN 111013014 A CN111013014 A CN 111013014A
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- ZMXDDKWLCZADIW-UHFFFAOYSA-N N,N-Dimethylformamide Chemical compound CN(C)C=O ZMXDDKWLCZADIW-UHFFFAOYSA-N 0.000 description 18
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- UFHGABBBZRPRJV-UHFFFAOYSA-N Hydroxysanguinarine Chemical compound C12=CC=C3OCOC3=C2C(=O)N(C)C(C2=C3)=C1C=CC2=CC1=C3OCO1 UFHGABBBZRPRJV-UHFFFAOYSA-N 0.000 description 1
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Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N1/00—Electrotherapy; Circuits therefor
- A61N1/18—Applying electric currents by contact electrodes
- A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
- A61N1/36—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
- A61N1/36046—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation of the eye
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/02—Inorganic materials
- A61L27/025—Other specific inorganic materials not covered by A61L27/04 - A61L27/12
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/02—Inorganic materials
- A61L27/08—Carbon ; Graphite
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/14—Macromolecular materials
- A61L27/16—Macromolecular materials obtained by reactions only involving carbon-to-carbon unsaturated bonds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/14—Macromolecular materials
- A61L27/18—Macromolecular materials obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N1/00—Electrotherapy; Circuits therefor
- A61N1/18—Applying electric currents by contact electrodes
- A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
- A61N1/36—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
- A61N1/3605—Implantable neurostimulators for stimulating central or peripheral nerve system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2430/00—Materials or treatment for tissue regeneration
- A61L2430/32—Materials or treatment for tissue regeneration for nerve reconstruction
Abstract
The invention provides a nerve tissue stimulation composite material which comprises a flexible piezoelectric polymer material and an inorganic photoinduced strain material distributed in the flexible piezoelectric polymer material. The nerve tissue stimulating composite material can generate an electric signal for stimulating nerve cells under the illumination of light with the wavelength of 200nm-2500 nm. The invention also provides a nerve tissue stimulation composite membrane and a nerve tissue prosthesis.
Description
Technical Field
The invention relates to the field of implantable neural tissue materials, in particular to a neural tissue stimulating composite material, a composite membrane and a neural tissue prosthesis.
Background
Vision is one of the most important ways for humans to obtain information. Retinal degenerative diseases such as retinitis pigmentosa, macular degeneration, etc. are the main causes of blindness in adults, and there is no effective clinical treatment for such diseases to date. Research shows that the blindness caused by retinal degeneration or photoreceptor cell disease still has a considerable number of neuron functions on the visual pathway of the blind to keep the intact, so that the implantable artificial retina stimulates nerve cells to recover partial visual ability. At present, some implantable electronic devices are used as visual prostheses, external image information is processed through a microprocessor, and pulse current stimulation is applied to neurons with intact visual nerve pathways by using a microelectrode array implanted in a human body, so that the vision of a patient is recovered to a certain extent. Such visual prostheses have proven clinically effective and have provided good news to blind patients. However, such visual prostheses usually need an external power supply unit and wireless transmission control, which brings great difficulty to the implantation operation, and meanwhile, the density of the electrodes of the microelectrode array is low, which affects the spatial resolution of vision to a certain extent, and the equipment is complex, and has the problems of signal crosstalk, more heat generation, difficult packaging and the like.
In recent years, passive visual prostheses based on photoelectric effect are developed, because the visual prostheses do not need the complex structure, optical signals are directly converted into electric signals and retina ganglion cells are stimulated, the operation difficulty is greatly reduced, and the passive visual prostheses have the advantages of simple structure, low cost and the like and are regarded as ideal solutions of artificial retinas. However, the current passive visual prosthesis which can reach the nerve cell stimulation threshold has a narrow response wavelength and is limited in practical use.
Disclosure of Invention
In view of the above, there is a need for a nerve tissue stimulating composite material that generates an electrical signal for stimulating nerve cells under illumination with a wavelength of 200nm to 2500 nm.
In addition, it is necessary to provide a complex neural tissue stimulation membrane.
In addition, it is necessary to provide a neural tissue prosthesis.
The invention provides a nerve tissue stimulation composite material which comprises a flexible piezoelectric polymer material and an inorganic photoinduced strain material distributed in the flexible piezoelectric polymer material.
Further, the flexible piezoelectric polymer material is selected from at least one of polyvinylidene fluoride and its copolymer, nylon with odd number of carbon atoms, polyacrylonitrile, polyimide, polyvinylidene cyanide and its copolymer, polyurea, polyphenyl cyano ether, polyvinyl chloride, polyvinyl acetate, polypropylene, polytetrafluoroethylene and ferroelectric liquid crystal.
Further, the inorganic photo-induced strain material is selected from at least one of an inorganic ferroelectric material, an inorganic semiconductor material and an inorganic photothermal deformation material.
Further, the inorganic ferroelectric material is selected from at least one of lead titanate, barium titanate, potassium niobate, lithium tantalate, bismuth titanate, bismuth layer-structured perovskite ferroelectrics, tungsten bronze type ferroelectrics, bismuth ferrite, potassium dihydrogen phosphate, ammonium triglycinate sulfate, rosette, perovskite type organic metal halide ferroelectrics, strontium ruthenate, and doped compounds thereof; the inorganic semiconductor material is selected from at least one of silicon, cadmium sulfide and gallium arsenide; the inorganic photothermal deformation material is selected from at least one of carbon nano tube, graphene and black phosphorus.
Further, the weight ratio of the flexible piezoelectric polymer material to the inorganic photoinduced strain material is 100: (1-50).
Further, the inorganic photo-induced strain material is in a granular shape, a linear shape, a tubular shape or a sheet shape.
Further, the particle size of the inorganic photoinduced strain material is 1nm-100 mu m; the length of the linear or tubular inorganic photoinduced strain material is 10nm-100 mu m, and the diameter of the linear or tubular inorganic photoinduced strain material is 1nm-10 mu m; the thickness of the flaky inorganic photoinduced strain material is 1nm-10 mu m.
The invention also provides a nerve tissue stimulation composite membrane, which is prepared from the nerve tissue stimulation composite material.
Further, the thickness of the composite membrane is 1-2000 μm.
The invention also provides a nerve tissue prosthesis which is prepared from the nerve tissue stimulation composite material.
Therefore, the nerve tissue stimulation composite material can generate an electric signal for stimulating nerve cells under the illumination of light with the wavelength of 200nm-2500 nm.
DETAILED DESCRIPTION OF EMBODIMENT (S) OF INVENTION
The technical solutions in the embodiments of the present invention will be clearly and completely described below with reference to the embodiments of the present invention. It is to be understood that the embodiments described are only a few embodiments of the present invention, and not all embodiments. All other embodiments, which can be obtained by a person skilled in the art without any inventive step based on the embodiments of the present invention, shall fall within the scope of protection of the present invention.
The embodiment of the invention provides a nerve tissue stimulation composite material, which is used for preparing a nerve tissue prosthesis, such as a retina, a brain nerve stimulation prosthesis, a spinal nerve stimulation prosthesis or a peripheral nerve stimulation prosthesis, and the like.
The term "nerve tissue stimulating composite material" of the present invention refers to a material capable of stimulating nerve cells of a human body to restore the original function of nerve tissue. For example, as a material for retinal prostheses, to restore visual function to blind persons.
The term "piezoelectric polymer material" as used herein refers to a polymer material that exhibits a voltage across its two terminal surfaces when subjected to a compressive force.
The term "flexible polymer" according to the present invention refers to a polymer having a chemical bond in the main chain with rotational freedom.
The term "photo-induced strain material" refers to a material that deforms under light conditions.
Specifically, the flexible piezoelectric polymer material and the inorganic photo-induced strain material may be compounded by a solution casting method, a blending method, a hot pressing method, or the like.
In some embodiments, the weight ratio of the flexible piezoelectric polymer material to the inorganic optically strained material is 100: (1-50). More specifically, the weight ratio of the flexible piezoelectric polymer material to the inorganic photo-strain material is 100: (1-30). More specifically, the weight ratio of the flexible piezoelectric polymer material to the inorganic photo-strain material is 100: (1-10). When the weight ratio of the flexible piezoelectric polymer material to the inorganic optically-strained material is in this range, the nerve tissue stimulating composite material has a better response performance.
In some embodiments, the flexible piezoelectric polymer material is selected from at least one of polyvinylidene fluoride and its copolymers, odd numbered carbon nylon, polyacrylonitrile, polyimide, polyvinylidine dicyanide and its copolymers, polyurea, polyphenylcyanoether, polyvinyl chloride, polyvinyl acetate, polypropylene, polytetrafluoroethylene, ferroelectric liquid crystal.
In some embodiments, the inorganic photo-strained material is selected from at least one of an inorganic ferroelectric material, an inorganic semiconductor material, and an inorganic photothermal deformation material.
The term "ferroelectric material" in the present invention refers to a class of materials having a ferroelectric effect.
The term "semiconducting material" as used herein refers to a material having semiconducting properties with a conductivity capability intermediate between that of a conductor and an insulator.
The term "photothermal deformation material" of the present invention refers to a material capable of deformation under the action of light or heat.
Specifically, the inorganic ferroelectric material may be selected from at least one of lead titanate, barium titanate, potassium niobate, lithium tantalate, bismuth titanate, bismuth layer-structured perovskite ferroelectrics, tungsten bronze type ferroelectrics, bismuth ferrite, potassium dihydrogen phosphate, ammonium triglycinate sulfate, rosette, perovskite type organic metal halide ferroelectrics, strontium ruthenate, and the above-mentioned dopants. The inorganic semiconductor material may be selected from at least one of silicon, cadmium sulfide, gallium arsenide. The inorganic photothermal deformation material can be selected from at least one of carbon nano tube, graphene and black phosphorus.
In some embodiments, the inorganic photo-straining material is granular, wire-like, tubular, or sheet-like.
In some embodiments, the inorganic photo-strainable material is uniformly distributed in the inorganic photo-strainable material in the flexible piezoelectric polymer material.
Further, the particle size of the inorganic photoinduced strain material is 1nm-100 mu m; the length of the linear or tubular inorganic photoinduced strain material is 10nm-100 mu m, and the diameter of the linear or tubular inorganic photoinduced strain material is 1nm-10 mu m; the thickness of the flaky inorganic photoinduced strain material is 1nm-10 mu m. Therefore, the electrical signal generated by the prepared nerve tissue composite material can better meet the requirement of nerve cell stimulation.
The nerve tissue stimulation composite material can generate an electric signal for stimulating nerve cells under the illumination of light with the wavelength of 200nm-2500nm and the intensity of 1-500mW/cm 2. More specifically, the open-circuit voltage can be generated in the range of 1mV to 50V, and the short-circuit current in the range of 1nA to 100 mA.
The invention also provides a nerve tissue stimulation composite membrane, which is prepared from the nerve tissue stimulation composite material provided by the embodiment of the invention, and the thickness of the composite membrane is 1-2000 mu m. When the thickness of the composite film is less than 1 mu m, the composite film is easy to break or the output power can not meet the requirement; when the thickness of the composite membrane exceeds 2000. mu.m, there is a difficulty in implantation into a living body.
The nerve tissue stimulation composite membrane provided by the embodiment of the invention is prepared by the following method:
1) dispersing the flexible piezoelectric polymer material and the inorganic photoinduced strain material in a solvent or uniformly mixing the materials in a solid state;
2) drying the solvent, and casting the solvent on the substrate to form a film or forming the film by a hot pressing mode and the like.
The present invention is described in more detail below with reference to specific examples, wherein the following parts are specifically indicated by weight.
Example 1
A nerve tissue stimulation composite membrane is prepared by compounding polyvinylidene fluoride (PVDF) and nano strontium ruthenate, wherein the grain diameter of the strontium ruthenate is 1nm, the thickness of the nerve tissue stimulation composite membrane is 10 microns, and the weight ratio of the PVDF to the strontium ruthenate is 100: 1.
The preparation method comprises the following steps:
1) dissolving PVDF in 100 parts by mass of N, N-dimethylformamide, adding strontium ruthenate nanoparticles, and uniformly stirring to obtain a mixed solution;
2) and casting the mixed solution on a clean glass substrate, drying for 12h at 80 ℃, and then taking the film from the glass substrate.
The prepared nerve tissue stimulation composite membrane can generate output voltage of more than 5V and output current of more than 100mA under the illumination of green light with the power of 100mW/cm2 and the wavelength of 532nm, and can stimulate visual ganglion cells to show excitability.
Example 2
A nerve tissue stimulation composite membrane is prepared by compounding Poly (vinylidene fluoride-trifluoroethylene) (Poly (vinylidene fluoride-trifluoroethylene), PVDF-TrFE) and bismuth ferrite nanowires, wherein the diameter of each bismuth ferrite nanowire is 1nm, the length of each bismuth ferrite nanowire is 100nm, the thickness of the nerve tissue stimulation composite membrane is 50 microns, the weight ratio of the Poly (vinylidene fluoride-trifluoroethylene) to the bismuth ferrite is 100:5, and the molar ratio of the vinylidene fluoride to the trifluoroethylene in the Poly (vinylidene fluoride-trifluoroethylene) is 7: 3.
The preparation method comprises the following steps:
1) dissolving PVDF-TrFE in 100 parts by mass of N, N-dimethylformamide, adding bismuth ferrite nanowires, and uniformly stirring to obtain a mixed solution;
2) and casting the mixed solution on a clean glass substrate, drying for 12h at 80 ℃, and then taking the film from the glass substrate.
The prepared nerve tissue stimulation composite membrane can generate output voltage of more than 5V and output current of more than 1nA under the illumination of 500mW/cm2 power and 400nm-800nm wavelength (visible light wave band), and can stimulate visual ganglion cells to show excitability.
Example 3
A nerve tissue stimulation composite membrane is prepared by compounding nylon 11 and a lead zirconate titanate film, wherein the thickness of the nylon 11 is 1nm, and the length and the width of the nylon 11 are 1cm x 1 cm; the thickness of the lead zirconate titanate film is 1nm, and the length and the width of the lead zirconate titanate film are 1cm x 1 cm; the thickness of the nerve tissue stimulation composite membrane is 1 μm.
The preparation method comprises the following steps:
1) alternately laminating nylon 11 and lead zirconate titanate films;
2) and hot pressing at 150 deg.C under 10MPa for 30min to obtain the composite film.
The prepared nerve tissue stimulation composite membrane can generate output voltage of more than 1V and output current of more than 5mA under the illumination of 200mW/cm2 (xenon lamp light source) power and 200nm-400nm (ultraviolet band), and can stimulate visual ganglion cells to show excitability.
Example 4
A nerve tissue stimulation composite membrane is prepared by compounding Polyacrylonitrile (PAN) and nano strontium ruthenate, wherein the grain diameter of the strontium ruthenate is 20nm, the thickness of the nerve tissue stimulation composite membrane is 1000 mu m, and the weight ratio of the polyacrylonitrile to the strontium ruthenate is 100: 1.
The preparation method comprises the following steps:
1) dissolving PAN in 100 parts by mass of N, N-dimethylformamide, adding strontium ruthenate, and uniformly stirring to obtain a mixed solution;
2) and casting the mixed solution on a clean glass substrate, drying for 12h at 80 ℃, and then taking the film from the glass substrate.
The prepared nerve tissue stimulation composite membrane can generate output voltage of more than 5V and output current of more than 10mA under the illumination of green light with the power of 100mW/cm2 and the wavelength of 532nm, and can stimulate visual ganglion cells to show excitability.
Example 5
A nerve tissue stimulation composite membrane is prepared by compounding polyimide and barium titanate, wherein the grain diameter of strontium ruthenate is 100 mu m, the thickness of the nerve tissue stimulation composite membrane is 1000 mu m, and the weight ratio of polyacrylonitrile to strontium ruthenate is 100: 5.
The preparation method comprises the following steps:
1) dissolving polyimide in 100 parts by mass of N, N-dimethylformamide, adding barium titanate, and uniformly stirring to obtain a mixed solution;
2) and casting the mixed solution on a clean glass substrate, drying for 12h at 80 ℃, and then taking the film from the glass substrate.
The prepared nerve tissue stimulation composite membrane can generate output voltage of more than 1mV and output current of more than 100mA under the illumination of 100mW/cm2 power and 400nm-800nm (visible light region) wavelength, and can stimulate visual ganglion cells to show excitability.
Example 6
A nerve tissue stimulation composite membrane is prepared by compounding polyurea and bismuth titanate, wherein the diameter of the bismuth titanate is 10 mu m, the length of the bismuth titanate is 100 mu m, the thickness of the nerve tissue stimulation composite membrane is 500 mu m, and the weight ratio of polyacrylonitrile to strontium ruthenate is 100: 5.
The preparation method comprises the following steps:
1) dissolving polyurea in 100 parts by mass of N, N-dimethylformamide, adding bismuth titanate, and uniformly stirring to obtain a mixed solution;
2) and casting the mixed solution on a clean glass substrate, drying for 12h at 80 ℃, and then taking the film from the glass substrate.
The prepared nerve tissue stimulation composite membrane can generate output voltage of more than 10V and output current of more than 1mA under the excitation of a sunlight simulation illumination system with the power of 200mW/cm2 and the wavelength of 400nm-800nm (visible light region), and can stimulate visual ganglion cells to show excitability.
Example 7
A nerve tissue stimulation composite membrane is prepared by compounding polyvinyl acetate and carbon nano tubes, wherein the diameter of each carbon nano tube is 10nm, the length of each carbon nano tube is 1 mu m, the thickness of the nerve tissue stimulation composite membrane is 2000 mu m, and the weight ratio of polyacrylonitrile to strontium ruthenate is 100: 5.
The preparation method comprises the following steps:
1) dissolving polyvinyl acetate in 100 parts by mass of N, N-dimethylformamide, adding carbon nanotubes, and uniformly stirring to obtain a mixed solution;
2) and casting the mixed solution on a clean glass substrate, drying for 12h at 80 ℃, and then taking the film from the glass substrate.
The prepared nerve tissue stimulation composite membrane can generate output voltage of more than 10V and output current of more than 20mA under the excitation of a sunlight simulation illumination system with the power of 200mW/cm2 and the wavelength of 400nm-800nm (visible light region), and can stimulate visual ganglion cells to show excitability.
The invention also provides a nerve tissue prosthesis, which is made of the nerve tissue stimulation composite material of the embodiment of the invention.
The "neural tissue prosthesis" of the present invention may include, but is not limited to, retina, brain nerve stimulation prosthesis, spinal nerve stimulation prosthesis or peripheral nerve stimulation prosthesis.
While the invention has been described with reference to specific embodiments, the invention is not limited thereto, and various equivalent modifications and substitutions can be easily made by those skilled in the art within the technical scope of the invention. Therefore, the protection scope of the present invention shall be subject to the protection scope of the claims.
Claims (10)
1. A nerve tissue stimulating composite comprising a flexible piezoelectric polymer material and an inorganic photo-induced strain material distributed within the flexible piezoelectric polymer material.
2. The nerve tissue stimulation composite of claim 1, wherein the flexible piezoelectric polymer material is selected from at least one of polyvinylidene fluoride and its copolymers, odd numbered nylon, polyacrylonitrile, polyimide, polyvinylidene cyanide and its copolymers, polyurea, polyphenylcyano ether, polyvinyl chloride, polyvinyl acetate, polypropylene, polytetrafluoroethylene, ferroelectric liquid crystal.
3. The nerve tissue stimulation composite according to claim 1, wherein the inorganic photo-strainable material is selected from at least one of an inorganic ferroelectric material, an inorganic semiconductor material, and an inorganic photothermal deformation material.
4. The nerve tissue stimulation composite according to claim 3, wherein the inorganic ferroelectric material is at least one selected from the group consisting of lead titanate, barium titanate, potassium niobate, lithium tantalate, bismuth titanate, bismuth layer-structured perovskite ferroelectrics, tungsten bronze type ferroelectrics, bismuth ferrite, potassium dihydrogen phosphate, ammonium trinitrate sulfate, rosette, perovskite type organic metal halide ferroelectrics, strontium ruthenate, and doped compounds thereof; the inorganic semiconductor material is selected from at least one of silicon, cadmium sulfide and gallium arsenide; the inorganic photothermal deformation material is selected from at least one of carbon nano tube, graphene and black phosphorus.
5. The nerve tissue stimulation composite of claim 1 wherein the weight ratio of the flexible piezoelectric polymer material to the inorganic photo-strain material is 100: (1-50).
6. The nerve tissue stimulation composite according to claim 1, wherein the inorganic photo-strainable material is in the form of particles, wires, tubes or sheets.
7. The nerve tissue stimulation composite according to claim 6, wherein the particle size of the inorganic photo-induced strain material is 1nm to 100 μm; the length of the linear or tubular inorganic photoinduced strain material is 10nm-100 mu m, and the diameter of the linear or tubular inorganic photoinduced strain material is 1nm-10 mu m; the thickness of the flaky inorganic photoinduced strain material is 1nm-10 mu m.
8. A composite neural tissue stimulation membrane, wherein the composite neural tissue stimulation membrane is made from the composite neural tissue stimulation material according to any one of claims 1 to 7.
9. The composite neural tissue stimulation membrane according to claim 8, wherein the thickness of the composite membrane is 1 μm to 2000 μm.
10. A neural tissue prosthesis, wherein the neural tissue prosthesis is made from the neural tissue stimulating composite of any one of claims 1 to 7.
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| CN112870391A (en) * | 2020-12-24 | 2021-06-01 | 深圳先进技术研究院 | Ferroelectric antibacterial material and preparation method and application thereof |
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| WO2016013848A1 (en) * | 2014-07-21 | 2016-01-28 | 서울대학교 산학협력단 | Polyvinylidene fluoride nanocomposite scaffold for cell culture, and method for producing same |
| WO2018213997A1 (en) * | 2017-05-22 | 2018-11-29 | 深圳先进技术研究院 | Deformable stimuli responsive material and preparation method therefor, and stimuli responsive flexible micro-electrode array |
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| WO2016013848A1 (en) * | 2014-07-21 | 2016-01-28 | 서울대학교 산학협력단 | Polyvinylidene fluoride nanocomposite scaffold for cell culture, and method for producing same |
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