CN111011388B - Application of dimethyl flavopenicillin in resisting plant pathogenic fungi - Google Patents
Application of dimethyl flavopenicillin in resisting plant pathogenic fungi Download PDFInfo
- Publication number
- CN111011388B CN111011388B CN201911304397.2A CN201911304397A CN111011388B CN 111011388 B CN111011388 B CN 111011388B CN 201911304397 A CN201911304397 A CN 201911304397A CN 111011388 B CN111011388 B CN 111011388B
- Authority
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- China
- Prior art keywords
- dimethyl
- use according
- methanol
- flavopenicillin
- acetone
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 125000000118 dimethyl group Chemical group [H]C([H])([H])* 0.000 title claims abstract description 26
- 244000000004 fungal plant pathogen Species 0.000 title claims abstract description 25
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 claims description 84
- CSCPPACGZOOCGX-UHFFFAOYSA-N Acetone Chemical compound CC(C)=O CSCPPACGZOOCGX-UHFFFAOYSA-N 0.000 claims description 40
- 238000000855 fermentation Methods 0.000 claims description 23
- 230000004151 fermentation Effects 0.000 claims description 23
- 239000000284 extract Substances 0.000 claims description 19
- 241000228257 Aspergillus sp. Species 0.000 claims description 18
- 241001052560 Thallis Species 0.000 claims description 17
- 238000010828 elution Methods 0.000 claims description 14
- 239000001963 growth medium Substances 0.000 claims description 14
- WEVYAHXRMPXWCK-UHFFFAOYSA-N Acetonitrile Chemical compound CC#N WEVYAHXRMPXWCK-UHFFFAOYSA-N 0.000 claims description 12
- 239000002609 medium Substances 0.000 claims description 12
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 12
- 238000013375 chromatographic separation Methods 0.000 claims description 11
- 238000000746 purification Methods 0.000 claims description 11
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- 244000052616 bacterial pathogen Species 0.000 claims description 10
- XEKOWRVHYACXOJ-UHFFFAOYSA-N Ethyl acetate Chemical compound CCOC(C)=O XEKOWRVHYACXOJ-UHFFFAOYSA-N 0.000 claims description 9
- 239000003480 eluent Substances 0.000 claims description 9
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 claims description 8
- 239000008103 glucose Substances 0.000 claims description 8
- 239000003960 organic solvent Substances 0.000 claims description 8
- 239000000843 powder Substances 0.000 claims description 8
- 238000004007 reversed phase HPLC Methods 0.000 claims description 8
- -1 dimethyl xanthocillin Chemical compound 0.000 claims description 7
- 235000007688 Lycopersicon esculentum Nutrition 0.000 claims description 6
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- 238000011068 loading method Methods 0.000 claims description 5
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- 238000004128 high performance liquid chromatography Methods 0.000 claims description 4
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- 229930187731 Xanthocillin Natural products 0.000 claims description 3
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- 229930182555 Penicillin Natural products 0.000 claims description 2
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- XEEYBQQBJWHFJM-UHFFFAOYSA-N Iron Chemical compound [Fe] XEEYBQQBJWHFJM-UHFFFAOYSA-N 0.000 description 4
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- RBRPTFMVULVGIC-UHFFFAOYSA-N xanthatin Natural products C1C=C(C=CC(C)=O)C(C)CC2OC(=O)C(=C)C21 RBRPTFMVULVGIC-UHFFFAOYSA-N 0.000 description 2
- XMAYWYJOQHXEEK-OZXSUGGESA-N (2R,4S)-ketoconazole Chemical compound C1CN(C(=O)C)CCN1C(C=C1)=CC=C1OC[C@@H]1O[C@@](CN2C=NC=C2)(C=2C(=CC(Cl)=CC=2)Cl)OC1 XMAYWYJOQHXEEK-OZXSUGGESA-N 0.000 description 1
- 244000063299 Bacillus subtilis Species 0.000 description 1
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- 206010012735 Diarrhoea Diseases 0.000 description 1
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- 206010061217 Infestation Diseases 0.000 description 1
- 241000588747 Klebsiella pneumoniae Species 0.000 description 1
- 244000141359 Malus pumila Species 0.000 description 1
- 235000011430 Malus pumila Nutrition 0.000 description 1
- 235000015103 Malus silvestris Nutrition 0.000 description 1
- 240000007594 Oryza sativa Species 0.000 description 1
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- 208000005374 Poisoning Diseases 0.000 description 1
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- 241000223238 Trichophyton Species 0.000 description 1
- 241001045770 Trichophyton mentagrophytes Species 0.000 description 1
- 238000003811 acetone extraction Methods 0.000 description 1
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- 230000000844 anti-bacterial effect Effects 0.000 description 1
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- 235000013305 food Nutrition 0.000 description 1
- 230000002538 fungal effect Effects 0.000 description 1
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- 230000006872 improvement Effects 0.000 description 1
- JEIPFZHSYJVQDO-UHFFFAOYSA-N iron(III) oxide Inorganic materials O=[Fe]O[Fe]=O JEIPFZHSYJVQDO-UHFFFAOYSA-N 0.000 description 1
- 229960004125 ketoconazole Drugs 0.000 description 1
- 150000002576 ketones Chemical class 0.000 description 1
- 230000007774 longterm Effects 0.000 description 1
- 231100000053 low toxicity Toxicity 0.000 description 1
- 125000004170 methylsulfonyl group Chemical group [H]C([H])([H])S(*)(=O)=O 0.000 description 1
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Classifications
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N47/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom not being member of a ring and having no bond to a carbon or hydrogen atom, e.g. derivatives of carbonic acid
- A01N47/40—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom not being member of a ring and having no bond to a carbon or hydrogen atom, e.g. derivatives of carbonic acid the carbon atom having a double or triple bond to nitrogen, e.g. cyanates, cyanamides
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Agronomy & Crop Science (AREA)
- Pest Control & Pesticides (AREA)
- Plant Pathology (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Dentistry (AREA)
- General Health & Medical Sciences (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Environmental Sciences (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
Abstract
Description
Claims (10)
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
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CN201911304397.2A CN111011388B (en) | 2019-12-17 | 2019-12-17 | Application of dimethyl flavopenicillin in resisting plant pathogenic fungi |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
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CN201911304397.2A CN111011388B (en) | 2019-12-17 | 2019-12-17 | Application of dimethyl flavopenicillin in resisting plant pathogenic fungi |
Publications (2)
Publication Number | Publication Date |
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CN111011388A CN111011388A (en) | 2020-04-17 |
CN111011388B true CN111011388B (en) | 2021-07-23 |
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CN201911304397.2A Active CN111011388B (en) | 2019-12-17 | 2019-12-17 | Application of dimethyl flavopenicillin in resisting plant pathogenic fungi |
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CN (1) | CN111011388B (en) |
Families Citing this family (1)
Publication number | Priority date | Publication date | Assignee | Title |
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CN111602662B (en) * | 2020-06-22 | 2021-12-14 | 深圳大学 | Preparation method and application of tricobactin |
Family Cites Families (1)
Publication number | Priority date | Publication date | Assignee | Title |
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CN101265214B (en) * | 2008-05-15 | 2014-07-23 | 中国医学科学院医药生物技术研究所 | Methylophtocillin ester and its salts, and preparation method, application and pharmaceutical composition thereof |
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2019
- 2019-12-17 CN CN201911304397.2A patent/CN111011388B/en active Active
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CN111011388A (en) | 2020-04-17 |
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Application publication date: 20200417 Assignee: Suzhou Nicholas Intelligent Equipment Co.,Ltd. Assignor: SHENZHEN University Contract record no.: X2022980024369 Denomination of invention: The Application of a Dimethyl Penicillin in the Resistance to Plant Pathogenic Fungi Granted publication date: 20210723 License type: Common License Record date: 20221201 |
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Application publication date: 20200417 Assignee: SHENZHEN MIGOU NETWORK TECHNOLOGY Co.,Ltd. Assignor: SHENZHEN University Contract record no.: X2022980026323 Denomination of invention: The Application of a Dimethyl Penicillin in the Resistance to Plant Pathogenic Fungi Granted publication date: 20210723 License type: Common License Record date: 20221212 Application publication date: 20200417 Assignee: Shenzhen Dongfang Renshou Life Technology Co.,Ltd. Assignor: SHENZHEN University Contract record no.: X2022980025926 Denomination of invention: The Application of a Dimethyl Penicillin in the Resistance to Plant Pathogenic Fungi Granted publication date: 20210723 License type: Common License Record date: 20221211 Application publication date: 20200417 Assignee: Shenzhen Bangqi Technology Innovation Co.,Ltd. Assignor: SHENZHEN University Contract record no.: X2022980026142 Denomination of invention: The Application of a Dimethyl Penicillin in the Resistance to Plant Pathogenic Fungi Granted publication date: 20210723 License type: Common License Record date: 20221211 Application publication date: 20200417 Assignee: Shenzhen No.7 Network Technology Co.,Ltd. Assignor: SHENZHEN University Contract record no.: X2022980026329 Denomination of invention: The Application of a Dimethyl Penicillin in the Resistance to Plant Pathogenic Fungi Granted publication date: 20210723 License type: Common License Record date: 20221212 Application publication date: 20200417 Assignee: Shenzhen Houze Biotechnology Co.,Ltd. Assignor: SHENZHEN University Contract record no.: X2022980026682 Denomination of invention: The Application of a Dimethyl Penicillin in the Resistance to Plant Pathogenic Fungi Granted publication date: 20210723 License type: Common License Record date: 20221210 |
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Application publication date: 20200417 Assignee: Shenzhen kangruihua Medical Technology Co.,Ltd. Assignor: SHENZHEN University Contract record no.: X2023980045648 Denomination of invention: Application of a Dimethyl Yellow Penicillin in Resistance to Plant Pathogenic Fungi Granted publication date: 20210723 License type: Common License Record date: 20231103 Application publication date: 20200417 Assignee: Shenzhen Ruikanghua Medical Technology Co.,Ltd. Assignor: SHENZHEN University Contract record no.: X2023980045608 Denomination of invention: Application of a Dimethyl Yellow Penicillin in Resistance to Plant Pathogenic Fungi Granted publication date: 20210723 License type: Common License Record date: 20231103 |
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Application publication date: 20200417 Assignee: Shenzhen Huahong marine biomedical Co.,Ltd. Assignor: SHENZHEN University Contract record no.: X2023980048266 Denomination of invention: Application of a Dimethyl Xanthpenicillin in the Treatment of Plant Pathogenic Fungi Granted publication date: 20210723 License type: Common License Record date: 20231123 Application publication date: 20200417 Assignee: Huada import and export trade (Hainan) Co.,Ltd. Assignor: SHENZHEN University Contract record no.: X2023980048264 Denomination of invention: Application of a Dimethyl Xanthpenicillin in the Treatment of Plant Pathogenic Fungi Granted publication date: 20210723 License type: Common License Record date: 20231123 |
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Application publication date: 20200417 Assignee: Guangdong Whale Biotechnology Co.,Ltd. Assignor: SHENZHEN University Contract record no.: X2023980048812 Denomination of invention: Application of a Dimethyl Xanthpenicillin in the Treatment of Plant Pathogenic Fungi Granted publication date: 20210723 License type: Common License Record date: 20231129 Application publication date: 20200417 Assignee: Guangdong Bonn Life Sciences Co.,Ltd. Assignor: SHENZHEN University Contract record no.: X2023980048412 Denomination of invention: Application of a Dimethyl Xanthpenicillin in the Treatment of Plant Pathogenic Fungi Granted publication date: 20210723 License type: Common License Record date: 20231127 |
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Application publication date: 20200417 Assignee: Shenzhen Tiantian Biological Group Co.,Ltd. Assignor: SHENZHEN University Contract record no.: X2023980049903 Denomination of invention: Application of a Dimethyl Xanthpenicillin in the Treatment of Plant Pathogenic Fungi Granted publication date: 20210723 License type: Common License Record date: 20231205 |
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