CN111001032A - Konjac glucomannan painless sewing patch and preparation method thereof - Google Patents
Konjac glucomannan painless sewing patch and preparation method thereof Download PDFInfo
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- CN111001032A CN111001032A CN201911349282.5A CN201911349282A CN111001032A CN 111001032 A CN111001032 A CN 111001032A CN 201911349282 A CN201911349282 A CN 201911349282A CN 111001032 A CN111001032 A CN 111001032A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L17/00—Materials for surgical sutures or for ligaturing blood vessels ; Materials for prostheses or catheters
- A61L17/06—At least partially resorbable materials
- A61L17/10—At least partially resorbable materials containing macromolecular materials
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L17/00—Materials for surgical sutures or for ligaturing blood vessels ; Materials for prostheses or catheters
- A61L17/005—Materials for surgical sutures or for ligaturing blood vessels ; Materials for prostheses or catheters containing a biologically active substance, e.g. a medicament or a biocide
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L17/00—Materials for surgical sutures or for ligaturing blood vessels ; Materials for prostheses or catheters
- A61L17/06—At least partially resorbable materials
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L17/00—Materials for surgical sutures or for ligaturing blood vessels ; Materials for prostheses or catheters
- A61L17/14—Post-treatment to improve physical properties
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- D—TEXTILES; PAPER
- D01—NATURAL OR MAN-MADE THREADS OR FIBRES; SPINNING
- D01F—CHEMICAL FEATURES IN THE MANUFACTURE OF ARTIFICIAL FILAMENTS, THREADS, FIBRES, BRISTLES OR RIBBONS; APPARATUS SPECIALLY ADAPTED FOR THE MANUFACTURE OF CARBON FILAMENTS
- D01F1/00—General methods for the manufacture of artificial filaments or the like
- D01F1/02—Addition of substances to the spinning solution or to the melt
- D01F1/10—Other agents for modifying properties
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- D—TEXTILES; PAPER
- D01—NATURAL OR MAN-MADE THREADS OR FIBRES; SPINNING
- D01F—CHEMICAL FEATURES IN THE MANUFACTURE OF ARTIFICIAL FILAMENTS, THREADS, FIBRES, BRISTLES OR RIBBONS; APPARATUS SPECIALLY ADAPTED FOR THE MANUFACTURE OF CARBON FILAMENTS
- D01F8/00—Conjugated, i.e. bi- or multicomponent, artificial filaments or the like; Manufacture thereof
- D01F8/02—Conjugated, i.e. bi- or multicomponent, artificial filaments or the like; Manufacture thereof from cellulose, cellulose derivatives, or proteins
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- D—TEXTILES; PAPER
- D01—NATURAL OR MAN-MADE THREADS OR FIBRES; SPINNING
- D01F—CHEMICAL FEATURES IN THE MANUFACTURE OF ARTIFICIAL FILAMENTS, THREADS, FIBRES, BRISTLES OR RIBBONS; APPARATUS SPECIALLY ADAPTED FOR THE MANUFACTURE OF CARBON FILAMENTS
- D01F8/00—Conjugated, i.e. bi- or multicomponent, artificial filaments or the like; Manufacture thereof
- D01F8/04—Conjugated, i.e. bi- or multicomponent, artificial filaments or the like; Manufacture thereof from synthetic polymers
- D01F8/16—Conjugated, i.e. bi- or multicomponent, artificial filaments or the like; Manufacture thereof from synthetic polymers with at least one other macromolecular compound obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds as constituent
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- D—TEXTILES; PAPER
- D01—NATURAL OR MAN-MADE THREADS OR FIBRES; SPINNING
- D01F—CHEMICAL FEATURES IN THE MANUFACTURE OF ARTIFICIAL FILAMENTS, THREADS, FIBRES, BRISTLES OR RIBBONS; APPARATUS SPECIALLY ADAPTED FOR THE MANUFACTURE OF CARBON FILAMENTS
- D01F8/00—Conjugated, i.e. bi- or multicomponent, artificial filaments or the like; Manufacture thereof
- D01F8/18—Conjugated, i.e. bi- or multicomponent, artificial filaments or the like; Manufacture thereof from other substances
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/20—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing organic materials
- A61L2300/30—Compounds of undetermined constitution extracted from natural sources, e.g. Aloe Vera
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
- A61L2300/402—Anaestetics, analgesics, e.g. lidocaine
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
- A61L2300/404—Biocides, antimicrobial agents, antiseptic agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
- A61L2300/418—Agents promoting blood coagulation, blood-clotting agents, embolising agents
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Abstract
The invention relates to a konjac glucomannan painless sewing patch and a preparation method thereof. The preparation method of the konjac glucomannan painless sewing patch comprises the preparation of konjac glucomannan gel spinning solution, the preparation of a sponge inner core and the preparation of the konjac glucomannan painless sewing patch. The konjac glucomannan painless sewing patch disclosed by the invention takes konjac glucomannan as a carrier and is supplemented with other medicinal additives, so that the konjac glucomannan painless sewing patch has excellent biodegradability, air permeability, film-forming property, flexibility and antibacterial property, and is high in tensile strength and good in waterproof effect; compared with plastic materials, the konjac glucomannan serving as the main material of the painless sewing patch has high air permeability, strong water resistance and high economic benefit; the production process is simple, the product can be completely biodegraded, and the method is environment-friendly and low-carbon; the materials are convenient to obtain, the price is low, the wound is attached through the microfiber gel film, a wound sewing needle can be replaced, the wound is breathable and transparent, and the wound close-sewing operation treatment and intermediate dressing change and treatment are more convenient.
Description
Technical Field
The invention relates to a suture patch and a preparation method thereof, in particular to a konjac glucomannan painless suture patch and a preparation method thereof.
Background
In recent years, the medical level has been improved, the traditional suture technology can not meet the requirements of human beings, a painless suture plaster (zipstittch) invented in the united states is remarkably available, the painless suture plaster can enable wounds to be closed quickly, the painless suture plaster is applied to the fields of friction trauma, surgical operation, trauma suture technology and the like, the painless suture plaster at present is mainly made of high polymer plastic materials such as plastic films and the like, and the painless suture plaster is not widely used in the world. The traditional suture plaster is non-biodegradable, low in air permeability, poor in waterproof effect, limited by structure, low in medicinal value, simple in structure, short in medicinal effect time, only suitable for small wounds, low in durability and easy to consume. Can not be widely applied to various fields and has low economic benefit. Accordingly, there is a growing general interest in developing a novel painless suture sticker having a great improvement in air permeability, water resistance and durability.
The patent 'surgical needleless suture plaster' (application date: 2008.12.23) with the application number of 200820129810.7 adopts two medical adhesive tapes on opposite sides which are connected together by a plurality of plastic strips, wherein at least one medical adhesive tape is connected with the plastic strips by a magic tape, and the medical adhesive tape is used for tightening and adhering wounds when in use. The noninvasive suture plaster has the advantages of simple structure, low cost and extremely convenient use and operation, and can greatly shorten the time of wound suture treatment. The connection of the magic tape can adjust the fitting tightness of the wound at any time, thereby being beneficial to wound healing. However, the structure of the noninvasive suture plaster cannot be adjusted along with the shape of a wound, has high limitation, adopts plastic as a raw material, and does not accord with the environmental protection concept of the current society.
The patent with application number 201620894897.1 discloses a convenient sewing patch replacing sewing needles (application date: 2016.08.17). The convenient sewing patch comprises an elastic base layer and a sewing layer, wherein a sewing area is arranged in the middle of the sewing layer, and the sewing area consists of a plurality of sewing strips and hollow areas among the sewing strips. The suture strip is extremely fine, can replace a suture needle, promotes wound healing, reduces pain of a wounded person, and has no scar after wound healing; the suture layer has elasticity and plays a role in pulling and closing the wound; the suture plaster does not adopt antibiotics and other medicines, is suitable for various wounds with different sizes, and is suitable for various wounds in operation. However, the sewing patch has poor air permeability, insufficient tensile strength of the sewing strip, changeability and insufficient sewing force, does not meet the requirements of consumers and has high relative price.
The invention patent of application No. 201510434190.2 discloses an adhesive bandage and a preparation method and application thereof (application date: 2015.07.22), and the adhesive bandage comprises a fixed part, at least two connecting parts and at least two movable parts with the same number of connecting parts. Each of the connection portions is connected between the fixed portion and the movable portion corresponding to the connection portion. The fixed part and at least two movable parts are located the surface with one side and have stickness, and connecting portion all has elasticity. The invention has reasonable structure and strong practicability, realizes wound closure by reducing the gap between the movable part and the fixed part, and has the advantages of reducing the pain of a patient and reducing the risks of scar, anesthesia and the like compared with the prior suturing technology. However, the wound dressing has weak air permeability in the using process, so that the wound close closing strength is poor, and the wound dressing does not have popularization and application values.
With the development of the times, the development of painless noninvasive suture posts has great significance for surgical medicine, and is the development of historical significance for human medical history. The sustainable economic development is a reasonable economic development situation, so the material with high economic benefit is demanded. Under such circumstances, the conventional band-aid using plastic, gelatin, non-woven fabric or the like as a main material is obviously unable to meet the needs of the times.
Disclosure of Invention
The invention aims to solve the problems of overlarge structural limitation, poor air permeability and weak water resistance of the traditional suture patch, and provides a konjac glucomannan painless suture patch and a preparation method thereof. The konjac glucomannan painless suture sticker is prepared by taking konjac glucomannan as a main material, utilizing biodegradability, flexibility and film-forming property of the konjac glucomannan and assisting other medicinal substances (hyaluronic acid, graphene oxide and traditional Chinese medicine components), has the advantages of quickly closing wounds, adjustable structure, good air permeability and strong water resistance, and is suitable for various types of patients.
In order to achieve the purpose, the invention adopts the following technical scheme.
The invention relates to a preparation method of a konjac glucomannan painless sewing patch, which is characterized by comprising the following preparation steps:
(1) preparing konjac glucomannan gel spinning solution: mixing 6-8 parts by weight of methacrylic acid, 35-40 parts by weight of polythiamide, 2-8 parts by weight of orange peel pectin, 10-15 parts by weight of completed methyl chitosan, 11-14 parts by weight of sodium alginate, 15-20 parts by weight of konjac glucomannan, 3-5 parts by weight of agar, 3-8 parts by weight of tow protein, 5-10 parts by weight of tea polyphenol, 3-7 parts by weight of glycerol, 3-5 parts by weight of graphene oxide and 7-9 parts by weight of hyaluronic acid, adding the mixture into a reaction kettle, stirring for 30 minutes under the conditions of 60-80 ℃ and 600 r/min, adding 5-10 parts by weight of completed methyl cellulose sodium, stirring for 30 minutes under the conditions of 50-60 ℃ and 600 r/min, finally adding 2-3 parts by weight of genipin to obtain a blend, performing ultrasonic treatment for 3-6 hours at room temperature, and degassing to prepare the konjac glucomannan gel spinning solution;
(2) preparing a sponge inner core: dissolving 10-13 parts of konjac fine powder in 98-99 parts of ultrapure water, adding 2-3 parts of pseudo-ginseng powder, 1.5-2 parts of dandelion powder, 1-1.5 parts of honeysuckle powder, 2-2.5 parts of Chinese lobelia powder, 1.5-2 parts of rhubarb powder, 2.5-3 parts of rabdosia rubescens powder and 3-3.5 parts of folium isatidis powder, uniformly stirring, stirring for 60-90 minutes in a constant-temperature water bath kettle at 40-50 ℃ by using a magnetic stirrer at 400rpm, standing for 24 hours at room temperature to prepare konjac glucomannan gel, pre-freezing for 24 hours by using liquid nitrogen, then carrying out vacuum freeze-drying in a freeze dryer to prepare a sponge inner core, and shearing into a square block to obtain a sponge inner core block for later use;
(3) preparing the konjac glucomannan painless suture paste: fixing the sponge inner core block prepared in the step (2) on a receiving frame of a micro-flow spinning machine; and (2) injecting the konjac glucomannan gel spinning solution prepared in the step (1) into an injector of a micro-flow spinning machine, directly preparing a microfiber membrane on the inner core of the sponge through micro-flow spinning, and cutting to prepare the konjac glucomannan painless suture sticker.
The konjac glucomannan painless suture sticker disclosed by the invention has the advantages that the sponge inner core is opposite to a wound when in use, and the corresponding microfiber gel film enables the wound to be attached.
The konjac glucomannan painless sewing patch disclosed by the invention takes konjac glucomannan as a carrier and is supplemented with other medicinal auxiliaries, so that the konjac glucomannan painless sewing patch has excellent biodegradability, air permeability, film-forming property, flexibility and antibacterial property, and is high in tensile strength and good in waterproof effect; compared with plastic materials, the konjac glucomannan serving as the main material of the painless sewing patch has high air permeability, strong water resistance and high economic benefit; the biodegradable plastic can be completely biodegraded, is environment-friendly and low-carbon; the materials are convenient to obtain and the price is low; and the production process is simple.
The konjac glucomannan painless suture plaster provided by the invention can be used for adhering wounds by using the microfiber gel film, and can replace wound suture needles. The method of the joint ensures that the wound is ventilated and perspective, and is more convenient for the close-stitch operation treatment of the wound and the intermediate dressing change and treatment. The medical value of the hyaluronic acid, the graphene oxide and the traditional Chinese medicine components is obviously increased, and the hyaluronic acid plays roles in keeping cell moisture, protecting cells from being invaded by bacteria, accelerating the recovery of skin tissues, improving the healing and regeneration capacity of wounds, reducing scars, enhancing immunity and the like; the Chinese medicinal composition has good hemostatic effect, repercussive and analgesic effects, scar removing effect, and antibacterial effect. Therefore, the air permeability, the water resistance and the antibacterial property of the konjac glucomannan painless sewing patch are enhanced, the wound healing effect is obviously enhanced, the toughness of the konjac glucomannan painless sewing patch is improved, and the konjac glucomannan painless sewing patch can be repeatedly used. Therefore, the konjac glucomannan painless suture plaster has better biodegradability, air permeability, waterproofness, antibacterial property and flexibility. The prepared konjac glucomannan painless suture paste is subjected to the following performance tests:
(1) biodegradability
The suture patches were buried for 30 days and tested by soil burial.
(2) Air permeability
The test was carried out using an air permeability tester TQD-G1.
(3) Water-proof property
The konjac glucomannan painless suture plaster and the traditional woundplast are placed in clear water, and the water absorption rate is compared for 10 minutes.
(4) Elastic toughness
And (3) determining the maximum tensile strength of the konjac glucomannan painless suture sticker and the traditional band-aid, and comparing.
(5) Antibacterial property
Selection of test bacteria in combination with QB/T2591-2003 criteria
(6) Wound healing effect
The wound healing condition of a patient volunteer with a wound is regularly detected by using the konjac glucomannan painless suture plaster, the traditional suture technology and the traditional band-aid respectively.
The comparison of the konjac glucomannan painless suture sticker of the invention and the similar products sold in the market in the aspects of air permeability, water resistance, elastic toughness, antibacterial property and wound healing effect shows that the results are shown in table 1.
TABLE 1 comparison of the performances of the konjac glucomannan painless suture sticker of the present invention and similar products sold in the market
Through the comparison tests, the konjac glucomannan painless suture plaster has excellent performances, the indexes of the konjac glucomannan painless suture plaster exceed those of the commercially available traditional suture plaster, and the konjac glucomannan painless suture plaster can replace the existing suture plaster and can replace the traditional wound suture under certain conditions.
Detailed Description
In order to fully disclose the konjac glucomannan painless suture patch and the preparation method thereof, the invention is further described in detail by combining specific embodiments.
Embodiment 1 a konjac glucomannan painless suture patch and a preparation method thereof, comprising the following steps:
(1) preparing konjac glucomannan gel spinning solution: mixing 6 parts of methacrylic acid, 35 parts of polyphthalamide, 2 parts of orange peel pectin, 10 parts of carboxymethyl chitosan, 11 parts of sodium alginate, 15 parts of konjac glucomannan, 3 parts of agar, 3 parts of silk fibroin, 5 parts of tea polyphenol, 3 parts of glycerol, 3 parts of graphene oxide and 7 parts of hyaluronic acid in parts by weight, adding the mixture into a reaction kettle, stirring the mixture for 30 minutes at the temperature of 60 ℃ and the speed of 600 r/minute, adding 5 parts of carboxymethyl cellulose sodium, stirring the mixture for 30 minutes at the temperature of 50 ℃ and the speed of 600 r/minute, finally adding 2 parts of genipin to obtain a blend, performing ultrasonic treatment for 3 hours at the room temperature, and degassing to obtain a gel spinning solution;
(2) preparing a sponge inner core: dissolving 10 parts of konjac fine powder in 98 parts of ultrapure water, adding 2 parts of pseudo-ginseng powder, 1.5 parts of dandelion powder, 1 part of honeysuckle powder, 2 parts of Chinese lobelia powder, 1.5 parts of rhubarb powder, 2.5 parts of rabdosia rubescens powder and 3 parts of folium isatidis powder, uniformly stirring, stirring for 60 minutes in a constant-temperature water bath kettle at 40 ℃ by using a magnetic stirrer at 400rpm, standing for 24 hours at room temperature to prepare konjac glucomannan gel, pre-freezing for 24 hours by using liquid nitrogen, then carrying out vacuum freeze drying in a freeze dryer to prepare a sponge inner core, and shearing into a square block to obtain a sponge inner core block for later use; dissolving 10-13 parts of konjac fine powder in 98-99 parts of ultrapure water, adding 2-3 parts of pseudo-ginseng powder, 1.5-2 parts of dandelion powder, 1-1.5 parts of honeysuckle powder, 2-2.5 parts of Chinese lobelia powder, 1.5-2 parts of rhubarb powder, 2.5-3 parts of rabdosia rubescens powder and 3-3.5 parts of folium isatidis powder, uniformly stirring, stirring in a constant-temperature water bath kettle at 40-50 ℃, stirring for 60-90 minutes at 400rpm of a magnetic stirrer, standing at room temperature for 24 hours to prepare konjac glucomannan gel, pre-freezing for 24 hours by adopting liquid nitrogen, then carrying out vacuum freeze-drying in a freeze dryer to prepare a sponge inner core, shearing into squares to obtain a sponge inner core block for later use
(3) Preparing the konjac glucomannan painless suture paste: fixing the sponge inner core block prepared in the step (2) on a receiving frame of a micro-flow spinning machine; and (2) injecting the gel spinning solution prepared in the step (1) into an injector of a micro-flow spinning machine, directly preparing a microfiber membrane on the inner core of the sponge through micro-flow spinning, and cutting to prepare the konjac glucomannan painless suture sticker.
Embodiment 2 konjac glucomannan painless suture sticker and preparation method thereof
A preparation method of a konjac glucomannan painless suture sticker comprises the following steps:
(1) preparing konjac glucomannan gel spinning solution: mixing 8 parts by weight of methacrylic acid, 40 parts by weight of polyththalimide, 8 parts by weight of orange peel pectin, 15 parts by weight of carboxymethyl chitosan, 14 parts by weight of sodium alginate, 20 parts by weight of konjac glucomannan, 5 parts by weight of agar, 8 parts by weight of silk fibroin, 10 parts by weight of tea polyphenol, 7 parts by weight of glycerol, 5 parts by weight of graphene oxide and 9 parts by weight of hyaluronic acid, adding the mixture into a reaction kettle, stirring the mixture for 30 minutes at the temperature of 80 ℃ and the speed of 600 r/minute, adding 10 parts by weight of sodium carboxymethyl cellulose, stirring the mixture for 30 minutes at the temperature of 60 ℃ and the speed of 600 r/minute, finally adding 3 parts by weight of genipin to obtain a blend, performing ultrasonic treatment for 6 hours at the room temperature, and degassing to prepare a gel spinning solution;
(2) preparing a sponge inner core: dissolving 13 parts of konjac fine powder in 99 parts of ultrapure water, adding 3 parts of pseudo-ginseng powder, 2 parts of dandelion powder, 1.5 parts of honeysuckle powder, 2.5 parts of Chinese lobelia powder, 2 parts of rhubarb powder, 3 parts of rabdosia rubescens powder and 3.5 parts of folium isatidis powder, uniformly stirring, stirring for 90 minutes by using a magnetic stirrer at 400rpm in a constant-temperature water bath kettle at 50 ℃, standing for 24 hours at room temperature to prepare konjac glucomannan gel, pre-freezing for 24 hours by using liquid nitrogen, then performing vacuum freeze drying in a freeze dryer to prepare an inner core of a sponge, and shearing into a square block of 3cm multiplied by 3cm to obtain an inner core block of the sponge for later use;
(3) preparing the konjac glucomannan painless suture paste: and (3) fixing the sponge inner core block prepared in the step (2) on a receiving frame of a micro-flow spinning machine. And (2) injecting the gel bundle thread spinning solution prepared in the step (1) into an injector of a micro-flow spinning machine, directly preparing a microfiber membrane on an inner core of a sponge through micro-flow spinning, and cutting the microfiber membrane into blocks of 3cm multiplied by 3cm to prepare the konjac glucomannan painless sewing patch.
Embodiment 3 a konjac glucomannan painless suture patch and a preparation method thereof, comprising the following steps:
(1) preparing konjac glucomannan gel spinning solution: mixing 7 parts by weight of methacrylic acid, 37 parts by weight of polyththalimide, 5 parts by weight of orange peel pectin, 12 parts by weight of carboxymethyl chitosan, 13 parts by weight of sodium alginate, 17 parts by weight of konjac glucomannan, 4 parts by weight of agar, 5 parts by weight of tow protein, 7 parts by weight of tea polyphenol, 5 parts by weight of glycerol, 4 parts by weight of graphene oxide and 8 parts by weight of hyaluronic acid, adding the mixture into a reaction kettle, stirring the mixture for 30 minutes at the temperature of 70 ℃ and 600 r/min, adding 7 parts by weight of carboxymethyl cellulose sodium, stirring the mixture for 30 minutes at the temperature of 55 ℃ and 600 r/min, finally adding 2.5 parts by weight of genipin to obtain a blend, performing ultrasonic treatment for 4.5 hours at the room temperature, and degassing to obtain a gel spinning solution;
(2) preparing a sponge inner core: dissolving 12 parts of konjac fine powder in 98 parts of ultrapure water, adding 2.5 parts of pseudo-ginseng powder, 1.8 parts of dandelion powder, 1.2 parts of honeysuckle powder, 2.3 parts of Chinese lobelia powder, 1.8 parts of rhubarb powder, 2.7 parts of rabdosia rubescens powder and 3.3 parts of folium isatidis powder, uniformly stirring, stirring in a constant-temperature water bath kettle at 45 ℃, stirring for 75 minutes at 400rpm of a magnetic stirrer, standing for 24 hours at room temperature to prepare konjac glucomannan gel, pre-freezing for 24 hours by adopting liquid nitrogen, then performing vacuum freeze drying in a freeze dryer to prepare a sponge inner core, and shearing into a square block of 3cm multiplied by 3cm to obtain a sponge inner core block for later use;
(3) preparing the konjac glucomannan painless suture paste: and (3) fixing the sponge inner core block prepared in the step (2) on a receiving frame of a micro-flow spinning machine. And (2) injecting the gel bundle thread spinning solution prepared in the step (1) into an injector of a micro-flow spinning machine, directly preparing a microfiber membrane on an inner core of a sponge through micro-flow spinning, and cutting the microfiber membrane into blocks of 3cm multiplied by 3cm to prepare the konjac glucomannan painless sewing patch.
The above description is only a preferred embodiment of the present invention, and all equivalent changes and modifications made in accordance with the claims of the present invention should be covered by the present invention.
Claims (4)
1. A preparation method of a konjac glucomannan painless suture sticker is characterized by comprising the following preparation steps:
(1) preparing konjac glucomannan gel spinning solution: mixing 6-8 parts by weight of methacrylic acid, 35-40 parts by weight of polythiamide, 2-8 parts by weight of orange peel pectin, 10-15 parts by weight of completed methyl chitosan, 11-14 parts by weight of sodium alginate, 15-20 parts by weight of konjac glucomannan, 3-5 parts by weight of agar, 3-8 parts by weight of tow protein, 5-10 parts by weight of tea polyphenol, 3-7 parts by weight of glycerol, 3-5 parts by weight of graphene oxide and 7-9 parts by weight of hyaluronic acid, adding the mixture into a reaction kettle, stirring for 30 minutes under the conditions of 60-80 ℃ and 600 r/min, adding 5-10 parts by weight of completed methyl cellulose sodium, stirring for 30 minutes under the conditions of 50-60 ℃ and 600 r/min, finally adding 2-3 parts by weight of genipin to obtain a blend, performing ultrasonic treatment for 3-6 hours at room temperature, and degassing to prepare the konjac glucomannan gel spinning solution;
(2) preparing a sponge inner core: dissolving 10-13 parts of konjac fine powder in 98-99 parts of ultrapure water, adding 2-3 parts of pseudo-ginseng powder, 1.5-2 parts of dandelion powder, 1-1.5 parts of honeysuckle powder, 2-2.5 parts of Chinese lobelia powder, 1.5-2 parts of rhubarb powder, 2.5-3 parts of rabdosia rubescens powder and 3-3.5 parts of folium isatidis powder, uniformly stirring, stirring for 60-90 minutes in a constant-temperature water bath kettle at 40-50 ℃ by using a magnetic stirrer at 400rpm, standing for 24 hours at room temperature to prepare konjac glucomannan gel, pre-freezing for 24 hours by using liquid nitrogen, then carrying out vacuum freeze-drying in a freeze dryer to prepare a sponge inner core, and shearing into a square block to obtain a sponge inner core block for later use;
(3) preparing the konjac glucomannan painless suture paste: fixing the sponge inner core block prepared in the step (2) on a receiving frame of a micro-flow spinning machine; and (2) injecting the konjac glucomannan gel spinning solution prepared in the step (1) into an injector of a micro-flow spinning machine, directly preparing a microfiber membrane on the inner core of the sponge through micro-flow spinning, and cutting to prepare the konjac glucomannan painless suture sticker.
2. The method for preparing a konjac glucomannan painless suture sticker according to claim 1, wherein the sponge inner core block in the step (2) cuts the sponge inner core into a square block of 3cm x 3 cm.
3. The method for preparing a konjac glucomannan painless suture sticker according to claim 1, wherein the clipping of step (3) cuts the microfiber membrane into 3cm x 3cm squares.
4. A konjac glucomannan painless suture sticker prepared by any one of the methods of claims 1-3.
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Application publication date: 20200414 |