CN111000746A

CN111000746A - Moisturizing essence composition, moisturizing essence solid preparation and preparation method thereof

Info

Publication number: CN111000746A
Application number: CN201910578482.1A
Authority: CN
Inventors: 张金金; 杨登亮; 李传茂; 林娜妹; 张伟杰; 张楚标
Original assignee: GUANGZHOU BAIYUN LIANJIA FINE CHEMICAL FACTORY; Guangdong Danz Group Co Ltd; Guangzhou Keneng Cosmetic Research Co Ltd
Current assignee: GUANGZHOU BAIYUN LIANJIA FINE CHEMICAL FACTORY; Guangdong Danz Group Co Ltd; Guangzhou Keneng Cosmetic Research Co Ltd
Priority date: 2019-06-28
Filing date: 2019-06-28
Publication date: 2020-04-14
Anticipated expiration: 2039-06-28
Also published as: CN111000746B

Abstract

The invention provides a moisturizing essence composition, a moisturizing essence solid preparation and a preparation method thereof. The moisturizing essence composition comprises a loosening agent, a moisturizing component and an auxiliary material; wherein the moisturizing component comprises glycerol glucoside, pullulan and trehalose; the adding amount of the bulking agent is 0.015-9% based on the total mass of the moisturizing essence composition; the addition amount of the glycerol glucoside is 1-10%, the addition amount of the pullulan is 10-20%, and the addition amount of the trehalose is 50-70%; the addition amount of the auxiliary materials is 10-20%. The moisturizing essence composition disclosed by the invention has an excellent moisturizing effect, can be prepared into a solid preparation according to needs, is long in shelf life and high in stability, preferably does not contain preservatives and essence, and is suitable for people with allergic skin.

Description

Moisturizing essence composition, moisturizing essence solid preparation and preparation method thereof

Technical Field

The invention provides a moisturizing essence composition, a moisturizing essence solid preparation and a preparation method thereof, and belongs to the field of cosmetics.

Background

In recent years, the homogeneity of products among various brands in the cosmetic industry is increasingly apparent, the degree of identification is lacked, and consumers expect more personalized customized products. Because the cosmetic market products are various in types and the updating iteration speed is high, the differentiation innovation becomes more important. The brand loyalty of the user can be effectively improved by developing the brand-new cosmetic, the eyeball of the consumer is attracted, and the attention of the consumer to the brand and the purchasing power of the product are improved. With the continuous development of people on the cognition of cosmetics, the method quickly and effectively solves the problem of personal skin and improves the skin state, and becomes the mainstream trend of the product demand of consumers.

The existing moisturizing essence is generally liquid, has short shelf life and is inconvenient to carry. At present, some moisturizing essence powder, such as freeze-dried powder products, are easy to hang on the wall of a cosmetic bottle due to too light weight when being opened, and are mostly stored in a binary chamber, a matched special moisture-proof packaging design is needed, the moisturizing essence powder is usually added into the whole bottle for use, and the active substances have short shelf life and are used up in limited time. In addition, freeze-dried silk balls or collagen balls are also used as moisturizing essence in the market, but the moisturizing essence needs to be packaged by independent glass ampoules, is not easy to open and has high cost.

Therefore, the research on a novel moisturizing essence which is high in stability, light, and easy to carry becomes a technical problem to be solved urgently.

Disclosure of Invention

Problems to be solved by the invention

In view of the technical problems in the prior art, the invention firstly provides a moisturizing essence composition which has an excellent moisturizing effect, can be prepared into different shapes such as a sheet shape according to needs, preferably does not contain preservatives and essences, and is suitable for people with allergic skin.

Furthermore, the invention also provides a moisturizing essence solid preparation which breaks through the preparation method and the use mode of the traditional cosmetics, has good solubility and stability, long shelf life and is light and easy to carry.

Furthermore, the invention also provides a preparation method of the moisturizing essence solid preparation, and the preparation method is simple and feasible, and raw materials are easy to obtain.

Means for solving the problems

The invention provides a moisturizing essence composition which comprises a loosening agent, a moisturizing component and an auxiliary material; wherein the moisturizing component comprises glycerol glucoside, pullulan and trehalose; based on the total mass of the moisturizing essence composition,

the addition amount of the loosening agent is 0.015-9%;

the addition amount of the glycerol glucoside is 1-10%, the addition amount of the pullulan is 10-20%, and the addition amount of the trehalose is 50-70%;

the addition amount of the auxiliary materials is 10-20%.

The moisturizing essence composition comprises, by mass,

the addition amount of the loosening agent is 1.05-9%;

the addition amount of the glycerol glucoside is 4-10%, the addition amount of the pullulan is 12-20%, and the addition amount of the trehalose is 55-70%;

the addition amount of the auxiliary materials is 12-20%.

The moisturizing essence composition according to the present invention, wherein the bulking agent comprises citric acid and/or sodium bicarbonate.

The moisturizing essence composition provided by the invention is characterized in that the addition amount of citric acid is 0.005-4% by mass of the total moisturizing essence composition; preferably 0.4 to 4%; the addition amount of the sodium bicarbonate is 0.01-5%, preferably 0.65-5%.

The moisturizing essence composition provided by the invention is characterized in that the auxiliary material comprises polyvinyl alcohol.

The invention also provides a moisturizing essence solid preparation which comprises the moisturizing essence composition.

The moisturizing essence solid preparation is a moisturizing essence tablet, and preferably the thickness of the moisturizing essence tablet is 0.1-5mm, preferably 1-3 mm; the weight of the moisturizing essence tablet is 1-1000mg, preferably 50-200 mg.

The moisturizing essence solid preparation according to the present invention, wherein the moisturizing essence tablet has a hardness of more than 30 newtons, preferably 30.1-70 newtons.

The moisturizing essence solid preparation is placed in water or an aqueous cosmetic preparation, and has a disintegration time of less than 3min, preferably less than 1 min.

The invention also provides a preparation method of the moisturizing essence solid preparation, which comprises the step of mixing the components of the moisturizing essence composition and then pressing and molding the mixture.

ADVANTAGEOUS EFFECTS OF INVENTION

The moisturizing essence composition disclosed by the invention has an excellent moisturizing effect, can be prepared into a solid preparation according to needs, is long in shelf life and high in stability, preferably does not contain preservatives and essence, and is suitable for people with allergic skin.

Furthermore, the moisturizing essence solid preparation breaks through the preparation method and the use mode of the traditional cosmetics, has good solubility and stability, long shelf life, is light and easy to carry, has more diversified packaging forms on the premise of not influencing the moisturizing effect, is light and easy to open, can reduce the packaging cost of the product, and can be used according to the individual requirements of consumers.

Furthermore, the preparation method of the moisturizing essence solid preparation is simple and feasible, and raw materials are easy to obtain, so that the moisturizing essence solid preparation is suitable for mass production.

Detailed Description

Various exemplary embodiments, features and aspects of the invention will be described in detail below. The word "exemplary" is used exclusively herein to mean "serving as an example, embodiment, or illustration. Any embodiment described herein as "exemplary" is not necessarily to be construed as preferred or advantageous over other embodiments.

Furthermore, in the following detailed description, numerous specific details are set forth in order to provide a better understanding of the present invention. It will be understood by those skilled in the art that the present invention may be practiced without some of these specific details. In other instances, methods, means, devices and steps which are well known to those skilled in the art have not been described in detail so as not to obscure the invention.

All units used in the present invention are international standard units unless otherwise stated, and numerical values and numerical ranges appearing in the present invention should be understood to include systematic errors inevitable in industrial production.

As used herein, "room temperature" can mean a temperature of 15-30 ℃.

First embodiment

The first embodiment of the invention provides a moisturizing essence composition, which comprises a bulking agent, a moisturizing ingredient and an auxiliary material; wherein the moisturizing component comprises glycerol glucoside, pullulan and trehalose; based on the total mass of the moisturizing essence composition,

the addition amount of the loosening agent is 0.015-9%;

the addition amount of the auxiliary materials is 10-20%.

The moisturizing essence composition disclosed by the invention has an excellent moisturizing effect, can be prepared into a solid preparation according to needs, is long in shelf life and high in stability, preferably does not contain preservatives and essence, and is suitable for people with allergic skin. Specifically, the method comprises the following steps:

< bulking agent >

The loosening agent is very easy to dissolve in water, can be quickly dissolved after meeting water or water-based cosmetics, releases heat and generates bubbles, and can accelerate the dissolving speed of moisturizing components and auxiliary materials. In the invention, the addition amount of the bulking agent is 0.015-9%, preferably 1.05-9% of the total mass of the moisturizing essence composition; specifically, the bulking agent may be added in an amount of 1%, 2%, 3%, 4%, 5%, 6%, 7%, 8%, 9%, etc. When the content of the bulking agent is less than 0.015%, the moisturizing essence composition of the present invention needs an auxiliary external force such as stirring or shaking to accelerate dissolution and release thereof when it is used after being prepared into a solid preparation.

In particular, the bulking agent of the present invention may be citric acid and/or sodium bicarbonate. The citric acid is added in an amount of 0.005-4%, preferably 0.4-4%, based on the total mass of the moisturizing essence composition, for example: may be 0.1%, 1%, 1.5%, 2%, 2.5%, 3%, 3.5%. The sodium bicarbonate is added in an amount of 0.01 to 5%, preferably 0.65 to 5%, for example: may be 0.1%, 1%, 1.5%, 2%, 2.5%, 3%, 3.5%, 4%, 4.5%, etc. When the addition amount of the citric acid is 0.005-4% and the addition amount of the sodium bicarbonate is 0.01-5%, and the moisturizing essence composition is prepared into a solid preparation for use, the combination of the sodium bicarbonate and the citric acid is used as a bulking agent, so that the dissolution speed of the moisturizing ingredient and the auxiliary materials in water or water-type cosmetics can be effectively accelerated.

< moisture-retaining ingredient >

The moisturizing ingredients of the present invention include glycerol glucoside, pullulan, and trehalose. The glycerol glucoside, the pullulan and the trehalose can generate a synergistic effect, so that the moisturizing effect is further improved.

Glycerol glucoside

The glycerol glucoside in the moisturizing essence composition is a transparent colorless moisturizing agent, can effectively regulate the balance of water inside and outside cells, helps the skin activate the expression of aquaporins, promotes cell differentiation and the generation of collagen, enhances the skin barrier and repair functions, and increases the secretory expression of skin growth factors.

The glycerol glucoside is added in an amount of 1-10%, preferably 4-10%, based on the total mass of the moisturizing essence composition, such as: may be 2%, 3%, 5%, 6%, 7%, 8%, 9%, etc. When the addition amount of the glycerol glucoside is 1-10%, the moisturizing effect is good, and the skin is helped to improve the barrier function.

Pullulan polysaccharide

The pullulan in the moisturizing essence composition is extracellular water-soluble mucopolysaccharide which is produced by fermenting aureobasidium pullulans and is similar to glucan and xanthan gum, the polysaccharide is straight-chain polysaccharide which is formed by polymerizing maltotriose repeating units connected by α -1, 4 glycosidic bonds through α -1, 6 glycosidic bonds, the relative molecular mass is 2-200 ten thousand Da, the polymerization degree is 100-5000, a layer of invisible film can be formed on skin, the percutaneous water loss of the skin is effectively reduced, and the moisturizing essence composition has a good water locking effect.

The pullulan is added in an amount of 10-20%, preferably 12-20%, based on the total mass of the moisturizing essence composition, for example: may be 11%, 12%, 13%, 14%, 15%, 16%, 18%, etc. When the addition amount of the pullulan is 10-20%, the moisturizing effect is good, and the skin percutaneous water loss is effectively reduced.

Trehalose

The trehalose in the moisturizing essence composition is stable non-reducing disaccharide obtained from corn starch by a biological fermentation technology, and can help organisms to be suitable for various severe environments such as drying, freezing, high temperature, high-permeability state and the like, so that the biological activity of the organisms is maintained, and cells are protected against the invasion of external pressure. The trehalose has excellent moisture-keeping and water-holding functions on skin, can form a layer of special protective film on the surface of cells under a dry condition, can bind water molecules under the hydration action, and can replace water in the cells when water is lost, so that the skin cells are protected from being damaged. Unlike traditional humectant, trehalose has stable moisture-keeping performance under different humidity environments.

The addition amount of the trehalose is 50-70% by mass, preferably 55-70% by mass, based on the total mass of the moisturizing essence composition, and the addition amount of the trehalose is, for example: may be 52%, 58%, 60%, 62%, 65%, 68%, etc. When the addition amount of the trehalose is 50-70%, the cell protecting effect is good, and the resistance of skin to different environments is effectively improved.

< auxiliary materials >

In the moisturizing essence composition, auxiliary materials can be properly added, so that the texture of the moisturizing essence can be improved. In the present invention, the auxiliary material may include polyvinyl alcohol. Based on the total mass of the moisturizing essence composition, the addition amount of the auxiliary materials is 10-20%, preferably 12-20%, for example: may be 11%, 13%, 14%, 15%, 16%, 17%, 18%, 19%, etc.

Specifically, the polyvinyl alcohol in the moisturizing essence composition can be the polyvinyl alcohol with the average polymerization degree (n) of 500-600 and the alcoholysis degree of 80-95%, is a very safe high-molecular organic substance, has no toxicity or side effects on a human body, has good biocompatibility, and is used as an auxiliary material of the moisturizing essence composition. Along with the dissolution of the moisturizing essence composition in water, the polyvinyl alcohol can be quickly dissolved to form a moisturizing essence liquid product with certain viscosity, moist texture and no stickiness.

In the invention, when the auxiliary material is polyvinyl alcohol, the addition amount of the polyvinyl alcohol is 10-20%, preferably 12-20% by total mass of the moisturizing essence composition, for example: may be 11%, 13%, 14%, 15%, 16%, 17%, 18%, 19%, etc. When the content of the polyvinyl alcohol is within the range of 10-20%, the polyvinyl alcohol can be used as an auxiliary material of the moisturizing essence composition to provide certain texture and viscosity.

Second embodiment

The second embodiment of the present invention provides a moisturizing essence solid preparation comprising the moisturizing essence composition of the first embodiment of the present invention. Specifically, the moisturizing essence solid preparation of the present invention can be obtained by freeze-drying and compression molding techniques.

According to the invention, the moisturizing essence composition is uniformly mixed, a novel cosmetic which is fresh and can not contain preservatives and essence is formed by utilizing freeze drying and compression molding technologies, the using addition amount of the moisturizing essence solid preparation can be selected according to the skin requirements of consumers, and the moisturizing essence solid preparation can be used as essence after being rapidly dissolved in water or water-based cosmetics.

Furthermore, the consumer can also adjust the demand quantity at any time according to the moisture content of self skin to more nimble freshness of having guaranteed the use product, easily realize individualized customization, promote the attention degree of consumer to self skin management and the experience sense when the product uses.

The application method of the moisturizing essence solid preparation is that the moisturizing essence solid preparation is placed in water or water-based cosmetics and dissolved to obtain fresh moisturizing essence which is used in preparation. Specifically, the aqueous cosmetic may be a lotion or essence, preferably a lotion, which is effective in enhancing the moisturizing effect of the original product.

Further, the moisturizing essence solid preparation is placed in water or water-based cosmetics, and the disintegration time of the moisturizing essence solid preparation is less than 3min, preferably less than 1 min. In addition, the moisturizing essence solid preparation can be completely dissolved within 10 minutes, preferably completely dissolved within 5 minutes to form fresh moisturizing essence, and the moisturizing essence can be prepared for use.

Specifically, the moisturizing essence solid preparation of the present invention may be a tablet, a spherical preparation, a square preparation, etc. Preferably, the moisturizing essence solid preparation of the present invention is a tablet.

Moisture-keeping essence tablet

The moisturizing essence solid preparation can be prepared into moisturizing essence tablets preferably, and can be prepared by freeze drying and tabletting technologies. The moisturizing essence tablet disclosed by the invention is mild and safe, has an excellent moisturizing effect, can effectively improve the skin barrier function, is fresh, does not contain preservatives and essence, and is especially suitable for people with allergic skin. Meanwhile, the product has good solubility and stability, long shelf life, light weight and easy carrying.

Specifically, the thickness of the moisturizing essence tablet is 0.1-5mm, preferably 1-3 mm; the weight of the moisturizing essence tablet is 1-1000mg, preferably 50-200 mg. The weight of the moisturizing essence tablet is visual, a consumer can adjust the required dosage at any time according to the moisture content of the skin of the consumer, the moisturizing essence tablet is prepared and used at present, the freshness of a used product is ensured more flexibly, personalized customization is easy to realize, and the attention of the consumer to skin management and the experience of the product in use are improved.

Preferably, the moisturizing essence tablet of the present invention can obtain products with different shapes according to different tabletting molds, such as: the moisture-keeping essence tablet can be made into a circle, and the diameter of the circle can be 1mm-6 mm. Of course, the moisturizing essence tablet can also be quadrilateral, triangular and the like.

Further, in the present invention, the moisture-retention essence sheet has a hardness of more than 30 newtons, preferably 30.1 to 70 newtons. The moisturizing essence tablet disclosed by the invention has certain hardness, is not easy to break and is convenient to carry.

The moisturizing essence solid preparation is a brand-new preparation, breaks through the preparation method and the use mode of the traditional cosmetics, can be independently dissolved in liquid for use, for example, can be independently dissolved in water for use, and can also be matched with the commercially available water-based cosmetics for use. The moisturizing essence tablet disclosed by the invention is mild and safe, has an excellent moisturizing effect, can effectively improve the skin barrier function, is fresh, does not contain preservatives and essence, and is especially suitable for people with allergic skin. Meanwhile, the product has good solubility and stability, long shelf life, light weight and easy carrying.

Third embodiment

The third embodiment of the present invention provides a method for preparing a moisturizing essence solid preparation. The preparation method comprises the step of mixing the components of the moisturizing essence composition and then pressing and molding the mixture.

Further, the preparation method comprises the following steps:

mixing the moisturizing component and the auxiliary materials, vacuum freeze-drying, recovering to room temperature, crushing, and mixing with a loosening agent to obtain a primary mixture;

and (3) performing compression molding on the preliminary mixture to obtain the moisturizing essence solid preparation.

The moisturizing essence solid preparation can be packaged and stored in a sealed plastic bottle or an aluminum-plastic bubble cap packaging box, and can be independently subpackaged or bottled in a plurality of pieces.

Specifically, the invention also provides a preparation method of the moisturizing essence tablet, which specifically comprises the following steps:

and tabletting the preliminary mixture by using a tabletting machine to obtain the moisturizing essence tablet.

Preferably, the compression force for the tabletting process may be 3 to 10kN, preferably using a single punch tablet press.

Examples

Embodiments of the present invention will be described in detail below with reference to examples, but those skilled in the art will appreciate that the following examples are only illustrative of the present invention and should not be construed as limiting the scope of the present invention. The examples, in which specific conditions are not specified, were conducted under conventional conditions or conditions recommended by the manufacturer. The reagents or instruments used are not indicated by the manufacturer, and are all conventional products commercially available.

The parameters are tested according to the method and the instrument required by the pharmacopoeia of the people's republic of China 2015 edition:

disintegration time: ZB-1C type intelligent disintegration tester

And (3) hardness testing: YPD-300CLED type intelligent tablet hardness tester

Weight uniformity: sartorius CP225D quasi microbalance

Placing the moisturizing essence tablet in water, and recording the time from placing to just disintegrating, namely the disintegration time; and after the moisturizing essence tablet is completely dissolved, recording the time from the placement to the time when the moisturizing essence tablet is just completely dissolved, namely the dissolving time.

Example 1

Taking 0.1 weight part of citric acid, 0.2 weight part of sodium bicarbonate, 5 weight parts of glycerol glucoside, 10 weight parts of pullulan, 70 weight parts of trehalose and 14.7 weight parts of polyvinyl alcohol for later use.

Mixing glycerol glucoside, pullulan, trehalose and polyvinyl alcohol according to a ratio, vacuum freeze-drying, recovering to room temperature, crushing, uniformly mixing with sodium bicarbonate and citric acid, and pressing under a pressure of 4kN to prepare the moisturizing essence tablet I with the diameter of 2mm and the thickness of 3 mm.

The resulting tablets were tested for hardness, weight uniformity, disintegration time and dissolution time. The tablets showed an average weight of 100. + -. 2.55mg, a hardness of 33.16. + -. 2.24N, a disintegration time of 52. + -.5 s and a complete dissolution time in water of 240. + -.10 s, and the specific results are shown in Table 1.

Example 2

3 parts by weight of citric acid, 4 parts by weight of sodium bicarbonate, 1 part by weight of glycerol glucoside, 18 parts by weight of pullulan, 56 parts by weight of trehalose and 18 parts by weight of polyvinyl alcohol are taken for standby.

Mixing glycerol glucoside, pullulan, trehalose and polyvinyl alcohol according to a ratio, vacuum freeze-drying, recovering to room temperature, crushing, uniformly mixing with sodium bicarbonate and citric acid, and pressing under 8kN pressure to obtain the moisturizing essence tablet II with the diameter of 6mm and the thickness of 2 mm.

The resulting tablets were tested for hardness, weight uniformity, disintegration time and dissolution time. The tablets showed an average weight of 160. + -. 3.03mg, a hardness of 58.16. + -. 1.58N, a disintegration time of 35. + -.2 s and a complete dissolution time in water of 105. + -.4 s, the specific results are shown in Table 1.

Example 3

Taking 2 parts by weight of citric acid, 2.6 parts by weight of sodium bicarbonate, 5.4 parts by weight of glycerol glucoside, 20 parts by weight of pullulan, 50 parts by weight of trehalose and 20 parts by weight of polyvinyl alcohol for later use.

Mixing glycerol glucoside, pullulan, trehalose and polyvinyl alcohol according to a ratio, vacuum freeze-drying, recovering to room temperature, crushing, uniformly mixing with sodium bicarbonate and citric acid, and tabletting under the pressure of 6kN to obtain the moisturizing essence tablet III with the diameter of 4mm and the thickness of 2 mm.

The resulting tablets were tested for hardness, weight uniformity, disintegration time and dissolution time. The tablets showed an average weight of 125. + -. 4.22mg, a hardness of 50.16. + -. 1.36N, a disintegration time of 40. + -.4 s and a complete dissolution time in water of 180. + -.3 s, and the specific results are shown in Table 1.

Example 4

0.005 part by weight of citric acid, 0.01 part by weight of sodium bicarbonate, 10 parts by weight of glycerol glucoside, 10 parts by weight of pullulan, 69.985 parts by weight of trehalose and 10 parts by weight of polyvinyl alcohol are taken for standby.

Mixing glycerol glucoside, pullulan, trehalose and polyvinyl alcohol according to a ratio, vacuum freeze-drying, recovering to room temperature, crushing, uniformly mixing with sodium bicarbonate and citric acid, and tabletting under the pressure of 3kN to obtain the moisturizing essence tablet IV with the diameter of 2mm and the thickness of 1 mm.

The resulting tablets were tested for hardness, weight uniformity, disintegration time and dissolution time. The tablets showed an average weight of 50. + -. 4.22mg, a hardness of 30. + -. 1.36N, a disintegration time of 55. + -.4 s and a complete dissolution time in water of 280. + -.15 s, and the specific results are shown in Table 1.

Example 5

1.5 parts by weight of citric acid, 2 parts by weight of sodium bicarbonate, 3.5 parts by weight of glycerol glucoside, 15 parts by weight of pullulan, 68 parts by weight of trehalose and 10 parts by weight of polyvinyl alcohol are taken for standby.

Mixing glycerol glucoside, pullulan, trehalose and polyvinyl alcohol according to a ratio, vacuum freeze-drying, recovering to room temperature, crushing, uniformly mixing with sodium bicarbonate and citric acid, and tabletting under the pressure of 3kN to obtain the moisturizing essence tablet V with the diameter of 2mm and the thickness of 1 mm.

The resulting tablets were tested for hardness, weight uniformity, disintegration time and dissolution time. The tablets showed an average weight of 60. + -. 4.22mg, a hardness of 35. + -. 1.36N, a disintegration time of 40. + -.5 s and a complete dissolution time in water of 180. + -.10 s, the specific results are shown in Table 1.

Example 6

Taking 4 parts by weight of citric acid, 5 parts by weight of sodium bicarbonate, 10 parts by weight of glycerol glucoside, 20 parts by weight of pullulan, 50 parts by weight of trehalose and 11 parts by weight of polyvinyl alcohol for later use.

Mixing glycerol glucoside, pullulan, trehalose and polyvinyl alcohol according to a ratio, vacuum freeze-drying, recovering to room temperature, crushing, uniformly mixing with sodium bicarbonate and citric acid, and tabletting under the pressure of 10kN to obtain the moisturizing essence tablet VI with the diameter of 6mm and the thickness of 3 mm.

The resulting tablets were tested for hardness, weight uniformity, disintegration time and dissolution time. The tablets showed an average weight of 196. + -. 3.03mg, a hardness of 53.02. + -. 2.80N, a disintegration time of 22. + -.4 s and a complete dissolution time in water of 45. + -.5 s, the specific results are shown in Table 1.

Comparative example 1

Taking 5 parts by weight of glycerol glucoside, 10 parts by weight of pullulan, 70 parts by weight of trehalose and 14.7 parts by weight of polyvinyl alcohol for later use.

Mixing glycerol glucoside, pullulan, trehalose and polyvinyl alcohol according to a ratio, vacuum freeze-drying, recovering to room temperature, crushing, and tabletting under a pressure of 4kN to obtain a moisturizing essence tablet VII with a diameter of 2mm and a thickness of 3 mm.

The resulting tablets were tested for hardness, weight uniformity, disintegration time and dissolution time. The tablets showed an average weight of 101. + -. 1.50mg, a hardness of 34.06. + -. 1.28N, a disintegration time of 52. + -.8 s and a complete dissolution time in water of 25. + -. 0.5 minutes, the specific results are shown in Table 1.

Comparative example 2

Taking 0.1 weight part of citric acid, 0.2 weight part of sodium bicarbonate, 10 weight parts of pullulan, 70 weight parts of trehalose and 14.7 weight parts of polyvinyl alcohol for later use.

The pullulan, the trehalose and the polyvinyl alcohol are uniformly mixed according to the proportion, and the mixture is pressed into a moisturizing essence sheet VIII with the diameter of 2mm and the thickness of 3mm under the pressure of 4 kN.

The resulting tablets were tested for hardness, weight uniformity, disintegration time and dissolution time. The tablets showed an average weight of 102. + -. 3.55mg, a hardness of 75.56. + -. 2.08N, a disintegration time of 53. + -.4 s and a complete dissolution time in water of 245. + -.5 s, and the specific results are shown in Table 1.

Comparative example 3

Taking 2 parts by weight of citric acid, 2.6 parts by weight of sodium bicarbonate, 40 parts by weight of glycerol glucoside, 20 parts by weight of pullulan, 50 parts by weight of trehalose and 20 parts by weight of polyvinyl alcohol for later use.

Mixing glycerol glucoside, pullulan, trehalose and polyvinyl alcohol according to a ratio, vacuum freeze-drying, recovering to room temperature, crushing, uniformly mixing with sodium bicarbonate and citric acid, and tabletting under the pressure of 6kN to obtain the moisturizing essence tablet IX with the diameter of 4mm and the thickness of 2 mm.

The resulting tablets were tested for hardness, weight uniformity, disintegration time and dissolution time. The tablets showed an average weight of 115. + -. 4.22mg, a hardness of 22.16. + -. 1.36N, a disintegration time of 38. + -.4 s and a complete dissolution time in water of 400. + -.15 s, and the specific results are shown in Table 1.

Comparative example 4

Taking 4 parts by weight of citric acid, 5 parts by weight of sodium bicarbonate, 10 parts by weight of glycerol glucoside, 35 parts by weight of pullulan, 50 parts by weight of trehalose and 11 parts by weight of polyvinyl alcohol for later use.

Mixing glycerol glucoside, pullulan, trehalose and polyvinyl alcohol according to a ratio, vacuum freeze-drying, recovering to room temperature, crushing, uniformly mixing with sodium bicarbonate and citric acid, and pressing under 10kN pressure to prepare the moisturizing essence tablet X with the diameter of 6mm and the thickness of 3 mm.

The resulting tablets were tested for hardness, weight uniformity, disintegration time and dissolution time. The tablets showed an average weight of 197. + -. 2.16mg, a hardness of 50.02. + -. 1.60N, a disintegration time of 65. + -.4 s and a complete dissolution time in water of 2. + -. 0.5 hours, the specific results are shown in Table 1.

Comparative example 5

Taking 4 parts by weight of citric acid, 5 parts by weight of sodium bicarbonate, 10 parts by weight of glycerol glucoside, 20 parts by weight of pullulan and 50 parts by weight of trehalose for later use.

Mixing glycerol glucoside, pullulan and trehalose according to a ratio, vacuum freeze-drying, returning to room temperature, crushing, uniformly mixing with sodium bicarbonate and citric acid, and pressing under 10kN pressure to prepare the moisturizing essence tablet XI with the diameter of 6mm and the thickness of 3 mm.

The resulting tablets were tested for hardness, weight uniformity, disintegration time and dissolution time. The tablets showed an average weight of 196. + -. 1.85mg, a hardness of 28.46. + -. 0.88N, a disintegration time of 15. + -.2 s and a complete dissolution time in water of 35. + -.3 s, and the specific results are shown in Table 1.

Comparative example 6

Taking 4 parts by weight of citric acid, 5 parts by weight of sodium bicarbonate, 10 parts by weight of glycerol glucoside, 20 parts by weight of pullulan and 11 parts by weight of polyvinyl alcohol for later use.

Mixing glycerol glucoside, pullulan and polyvinyl alcohol according to a ratio, vacuum freeze-drying, recovering to room temperature, crushing, uniformly mixing with sodium bicarbonate and citric acid, and pressing under 10kN pressure to prepare the moisturizing essence tablet XII with the diameter of 6mm and the thickness of 3 mm.

The resulting tablets were tested for hardness, weight uniformity, disintegration time and dissolution time. The tablets showed an average weight of 196. + -. 3.03mg, a hardness of 52.74. + -. 1.80N, a disintegration time of 25. + -.1 s and a complete dissolution time in water of 15. + -.2 hours, the specific results are shown in Table 1.

Comparative example 7

Taking 4 parts by weight of citric acid, 5 parts by weight of sodium bicarbonate, 10 parts by weight of glycerol glucoside, 20 parts by weight of pullulan, 50 parts by weight of trehalose and 30 parts by weight of polyvinyl alcohol for later use.

Mixing glycerol glucoside, pullulan, trehalose and polyvinyl alcohol according to a ratio, vacuum freeze-drying, returning to room temperature, crushing, uniformly mixing with sodium bicarbonate and citric acid, and pressing under 10kN pressure to prepare the moisturizing essence tablet XIII with the diameter of 6mm and the thickness of 3 mm.

The resulting tablets were tested for hardness, weight uniformity, disintegration time and dissolution time. The tablets showed an average weight of 193. + -. 2.96mg, a hardness of 52.52. + -. 2.42N, a disintegration time of 21. + -.4 s and a complete dissolution time in water of 7. + -. 0.5 hours, the specific results are shown in Table 1.

TABLE 1

Examples	Hardness of	Uniformity of weight/mg	Disintegration time/s	Dissolution time test/s
					Example 1	33.16±2.24	100±2.55	52±5	240±10
Example 2	58.16±1.58	160±3.03	35±2	105±4
					Example 3	50.16±1.36	125±4.22	40±4	180±3
Example 4	30±1.36	50±4.22	55±4	280±15
					Example 5	35±1.36	60±4.22	40±5	180±10
Example 6	53.02±2.80	196±3.03	22±4	45±5
					Comparative example 1	34.06±1.28	101±1.50	52±8	1500±30
Comparative example 2	75.56±2.08	102±3.55	53±4	245±5
					Comparative example 3	22.16±1.36	115±4.22	38±4	400±15
Comparative example 4	50.02±1.60	197±2.16	65±4	7200±1800
					Comparative example 5	28.46±0.88	196±1.85	15±2	35±3
Comparative example 6	52.74±1.80	196±3.03	25±1	54000±7200
					Comparative example 7	52.52±2.42	193±2.96	21±4	25200±1800

As can be seen from Table 1, in example 1, compared with comparative example 1, comparative example 1 does not contain a bulking agent, and has a dissolution time of 1500. + -.30 s, a long dissolution time and a slow dissolution.

Example 1 compared with comparative example 2, comparative example 2 does not contain glycerol glucoside, hardness becomes large, and the tablet is brittle.

Example 3 compared to comparative example 3, the content of glycerol glucoside in comparative example 3, which is outside the range of the present invention, results in a longer disintegration time, softer hardness and less solubility.

Example 6 compared to comparative example 4, the content of pullulan in comparative example 4 out of the range of the present invention resulted in difficult disintegration, extended dissolution time, sticky feeling in use after dissolving in water, and strong residual feeling.

Example 6 in comparison with comparative example 5, which does not contain polyvinyl alcohol, is not hard enough to withstand pressure although it is easily disintegrated and dissolved, and has a slow absorption rate in use after it is dissolved in water.

Example 6 in comparison with comparative example 6, trehalose was not contained in comparative example 6, making it difficult to dissolve.

Example 6 compared with comparative example 7, the content of the adjuvant of comparative example 7 is out of the range of the present invention, it is hardly dissolved, and it gives sticky feeling to the skin after dissolving in water.

Test of moisturizing Effect

5g of the moisturizing essence tablet I in example 1, the moisturizing essence tablet VI in example 6, the moisturizing essence tablet VIII in comparative example 2, the moisturizing essence tablet XII in comparative example 6 and the moisturizing essence tablet XIII in comparative example 7 are respectively weighed and dissolved in deionized water until the solutions are completely dissolved, so that a 5% aqueous solution is formed.

25 female volunteers were drawn at random. The subjects firstly clean the forearms of both hands, sit still for 30min under the environment of constant humidity (25 ℃, RH 43%), then use the two side regions of the left and right arms of the subjects as the control, each region is 3CM × 3CM, apply the same mass of 30mg samples until the samples are completely absorbed, test the moisture content (Corneometer Unit, C.U.) of the corresponding experimental part by the Corneometer CM825 instrument, repeat the experimental data 8 times respectively to obtain the average value of each test, calculate the average skin moisture content of 25 volunteers at different time intervals of 0h, 5min, 10min and 20min as shown in Table 2, compare the moisture content of the moisture-retaining sheet I of example 1, the moisture-retaining essence sheet VI of example 6, the moisture-retaining essence sheet VIII of comparative example 2, the moisture-retaining essence sheet XII of comparative example 6, the moisture-retaining essence sheet XIII of comparative example 7 and the skin moisture content of the blank control region.

TABLE 2 summary of skin moisture content data for 25 subjects at various times

In table 2, significance: "+" indicates a significant difference (p < 0.05); "-" indicates a non-significant difference (p > 0.05).

As can be seen from the data in table 2, the moisturizing essence tablets I and VI in examples 1 and 6 have significantly better skin moisture content and water retention effect within 20min of use and better moisturizing effect than the blank control area, the moisturizing essence tablet VIII in comparative example 2, the moisturizing essence tablet XII in comparative example 6, and the moisturizing essence tablet XIII in comparative example 7.

Comparative example 2 compared with example 1, although the average skin moisture content was significantly increased after 5min after application, the moisturizing essence tablet VIII did not contain glyceryl glucoside, and thus the moisturizing effect was significantly inferior to that of moisturizing essence tablet I.

Compared with the moisturizing essence tablet in example 6, although the moisturizing essence tablet XII in the comparative example 6 has a certain moisturizing effect within 20min, the average skin moisture content at each time node obviously does not reach the effect of the moisturizing essence tablet VI because trehalose is not added.

Compared with the moisturizing essence tablet XIII in example 6, although the moisture content of the skin is remarkably increased after 5min after the moisturizing essence tablet XIII is applied, the moisture retention effect of each time node is rapidly reduced due to the lack of polyvinyl alcohol to form an air-permeable water-locking film on the surface of the skin.

Stability test

40 pieces (10 pieces each) of the moisturizing essence tablets I to VI prepared in examples 1 to 6 and the moisturizing essence tablets VII to XIII prepared in comparative examples 1 to 7 were sealed in an aluminum blister pack, and stored in the following 4 environments to observe the degree of breakage and the molding stability of the tablets, respectively, and the results are shown in table 3 below.

The samples were allowed to stand at 25 ℃ and 60% RH at ambient temperature for comparative testing.

Cold resistance test: the freezer was left for 10 days.

And (3) cold-hot circulation: -18 ℃, 25% RH; 25 ℃ at 60% RH; 40 ℃, 75% RH, 24h each for 5 cycles.

High-temperature acceleration: the test conditions were 50 ℃ plus or minus 1 ℃ and 25% RH plus or minus 5% RH for 1 month.

TABLE 3

As can be seen from Table 3, the moisturizing essence tablets I-VI prepared in examples 1-6 have good stability under different environments. Meanwhile, the moisturizing essence tablets VII, X, XII and XIII prepared in comparative examples 1, 4, 6 and 7 are not damaged under different environments.

Compared with the moisturizing essence tablet I prepared in the example 1, the moisturizing essence tablet VIII prepared in the comparative example 2 has higher hardness due to no addition of glycerol glucoside, so that the tablet is too dry and not flexible enough, and the tablet is broken under different environments.

The moisturizing essence tablet IX prepared in comparative example 3 has a higher addition amount of glycerol glucoside compared with the moisturizing essence tablet III prepared in example 3, so that the tablet hardness is lower, and the tablet is too soft, so that the deformation and the soft collapse occur at high temperature.

Compared with the moisturizing essence tablet VI prepared in the example 6, the moisturizing essence tablet XI prepared in the comparative example 5 has cracked and broken appearance at different temperatures, and the molding is unstable due to insufficient hardness because polyvinyl alcohol is not added.

The above examples of the present invention are merely examples for clearly illustrating the present invention and are not intended to limit the embodiments of the present invention. Other variations and modifications will be apparent to persons skilled in the art in light of the above description. And are neither required nor exhaustive of all embodiments. Any modification, equivalent replacement, and improvement made within the spirit and principle of the present invention should be included in the protection scope of the claims of the present invention.

Claims

1. The moisturizing essence composition is characterized by comprising a bulking agent, a moisturizing component and auxiliary materials; wherein the moisturizing component comprises glycerol glucoside, pullulan and trehalose; based on the total mass of the moisturizing essence composition,

the addition amount of the loosening agent is 0.015-9%;

the addition amount of the auxiliary materials is 10-20%.

2. The moisturizing essence composition according to claim 1, wherein the moisture-retaining essence composition comprises, based on the total mass of the moisturizing essence composition,

the addition amount of the loosening agent is 1.05-9%;

the addition amount of the auxiliary materials is 12-20%.

3. The moisturizing essence composition according to claim 1 or 2, wherein the bulking agent comprises citric acid and/or sodium bicarbonate.

4. The moisturizing essence composition according to claim 3, wherein the citric acid is added in an amount of 0.005-4% by mass based on the total mass of the moisturizing essence composition; preferably 0.4 to 4%; the addition amount of the sodium bicarbonate is 0.01-5%, preferably 0.65-5%.

5. The moisturizing essence composition of any one of claims 1 to 4, wherein the excipient comprises polyvinyl alcohol.

6. A moisturizing essence solid preparation characterized by comprising the moisturizing essence composition according to any one of claims 1 to 5.

7. The moisturizing essence solid preparation according to claim 6, wherein the moisturizing essence solid preparation is a moisturizing essence tablet, preferably the thickness of the moisturizing essence tablet is 0.1-5mm, preferably 1-3 mm; the weight of the moisturizing essence tablet is 1-1000mg, preferably 50-200 mg.

8. The moisturizing essence solid preparation according to claim 7, wherein the moisturizing essence tablet has a hardness of more than 30 newtons, preferably 30.1-70 newtons.

9. The moisturizing essence solid preparation according to any one of claims 6 to 8, wherein the moisturizing essence solid preparation is placed in water or a water-based cosmetic, and the disintegration time of the moisturizing essence solid preparation is less than 3min, preferably less than 1 min.

10. The method for preparing the moisturizing essence solid preparation according to any one of claims 6 to 9, comprising the step of mixing the components of the moisturizing essence composition and then compression-molding the mixture.