CN110981720A - Diaryl acetate compound and preparation method thereof - Google Patents

Diaryl acetate compound and preparation method thereof Download PDF

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CN110981720A
CN110981720A CN201911345042.8A CN201911345042A CN110981720A CN 110981720 A CN110981720 A CN 110981720A CN 201911345042 A CN201911345042 A CN 201911345042A CN 110981720 A CN110981720 A CN 110981720A
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diaryl
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acetate
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魏国
杨慧
程仲彬
赵芬琴
张俨娜
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Henan University
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Abstract

The invention provides a diaryl acetate compound and a preparation method thereof, and the preparation method comprises the following steps: (1) adding diaryl 1, 2-diketone compounds, alcohol compounds, trialkyl phosphite and a photocatalyst into a reaction vessel, and adding a solvent for dissolving to obtain a reaction solution; (2) irradiating the reaction solution by using a light source and stirring the reaction solution until the reaction is complete; (3) and after the reaction is finished, recovering the solvent under reduced pressure and purifying by column chromatography to obtain the diaryl acetate compound. The invention starts from easily obtained diaryl 1, 2-diketone, has mild and green reaction conditions, does not need precious transition metal catalysis, is economic and environment-friendly, and has higher practicability.

Description

Diaryl acetate compound and preparation method thereof
Technical Field
The invention relates to the field of organic synthesis, in particular to diaryl acetate compounds and a preparation method thereof.
Background
Diaryl acetate structures are widespread among natural products and are available for many pharmaceutical molecules such as swertin and dinitrogen. Research shows that the structure has antiviral, rheumatism eliminating, antitumor, central nervous activity and serotonin dopamine reuptake inhibiting activity. The related documents are: (a) Xu, H.; Lv, M.; Tian, X. Curr. Med. chem.2009, 16, 327, (b) Keller, H.; Schafner, R.; Carruba, M. O.; Burkard, W.P.; Pieri, M.; Bonetti, E. P.; Scherschlich, R.; Prada, M. D.; Haefely, W.E. adv. biochem. Psychopharmacol. 1982, 31, 249. (c) Jacob, J. N.; Nichols, D. E.; Kohli, J. D.; Glock, D.J. chem. 1981, 24, 1013.
The preparation of diaryl acetic acid is mainly a transition metal catalyzed coupling method starting from monoaryl acetic acid ester. The recently developed metal coupling method of 2-azido acetate overcomes the harsh conditions of high temperature, strong alkali and the like of the traditional method.
Figure 556271DEST_PATH_IMAGE001
Related preparation and activity patents are also: (1) in the Chinese patent application of Zjunliang, university of east China, "a method for selective C-H bond functionalization of phenol and aniline under the catalysis of gold" (CN 103936537A), a method for realizing coupling of phenol or aniline and azido acetate by utilizing a gold catalyst is disclosed, and synthesis of diaryl acetate is realized; (2) international patent publication WO2007033781A1 discloses a palladium catalyzed coupling reaction between an aryl acetate and an aryl bromide directly under strongly basic conditions; (3) leehen in International patent WO2002079339A2 discloses the coupling of 2-bromoacetate and arylboronic acid under Pd (0) catalysis to form diarylacetate; (4) zhejiang Hebei pesticide chemical Co Ltd discloses a synthesis method for synthesizing diaryl acetate-bromopropylate by using glyoxylic acid, bromobenzene and isopropanol in Chinese patent 'a synthesis method of bromopropylate' (CN 103936537A).
However, the above preparation methods all use severe conditions such as strong alkali, and the reaction is not economical because the catalyst is catalyzed by expensive transition metal.
Disclosure of Invention
The invention provides a diaryl acetate compound and a preparation method thereof, which solve the problems of harsh reaction conditions and low efficiency in the prior art.
The technical scheme for realizing the invention is as follows:
a preparation method of diaryl acetate compounds comprises the following steps:
(1) adding diaryl 1, 2-diketone compounds, alcohol compounds, trialkyl phosphite and a photocatalyst into a reaction vessel, and adding a solvent for dissolving to obtain a reaction solution;
(2) irradiating the reaction solution by using a light source and stirring the reaction solution until the reaction is complete;
(3) and after the reaction is finished, recovering the solvent under reduced pressure and purifying by column chromatography to obtain the diaryl acetate compound.
The structural formula of the diaryl 1, 2-diketone compound in the step (1) is as follows:
Figure 100002_DEST_PATH_IMAGE002
wherein Ar is1And Ar2The same or different, and is selected from any one of phenyl, substituted phenyl, aromatic heterocycle, condensed ring aryl and condensed aromatic heterocycle substituent.
The structural formula of the alcohols in the step (1) is ROH, wherein R is a linear chain or branched chain alkyl of C1-C20.
The photocatalyst in the step (1) is DPZ, and the specific synthesis steps can be referred to as ZHao, Y., Zhang, C., Chin, K, F., Pyrela, O., Wei, G., Liu, H., Bure š, F., Jiang, Z.RSC A,dv.2014.4(57), 30062. The structural formula of the photocatalyst is as follows:
Figure 411094DEST_PATH_IMAGE003
。
the structural formula of the trialkyl phosphite in the step (1) is as follows: p (OR')3Wherein R' is a linear or branched alkyl of C1-C10.
The solvent in the step (1) is any one of acetonitrile, propionitrile, isopropyl nitrile, n-butyl nitrile, isobutyl nitrile, tert-butyl nitrile, dichloromethane, dichloroethane, chloroform, carbon tetrachloride, benzene, toluene, ethylbenzene, p-xylene, diethyl ether, THF, dioxane and dimethoxyethane.
In the step (1), the molar ratio of diaryl 1, 2-diketone compound, alcohol compound, trialkyl phosphite and photocatalyst is 1 (1-10): (1-3): (0.001-0.1), and the concentration of diaryl 1, 2-dione compound in the reaction solution is 0.01-1.0M.
The light source in the step (2) is a CFL bulb, sunlight or an LED lamp, the power range of the CFL bulb is 9-100W, the wavelength range of the LED lamp is 445-455nm, and the power is 1-10W.
The reaction process in the step (2) is protected by argon or nitrogen, and the reaction time is 2-7 days
The structural formula of the prepared diaryl acetate compound is as follows:
Figure DEST_PATH_IMAGE004
wherein Ar is1And Ar2The same or different, is selected from phenyl, substituted phenyl, aromatic heterocycle, condensed ring aryl and condensed aromatic heterocycle substituent; r is a straight chain or branched chain alkyl of C1-C20.
The reaction formula is as follows:
Figure 879247DEST_PATH_IMAGE005
wherein Ar is1And Ar2The same or different, is selected from phenyl, substituted phenyl, aromatic heterocycle, condensed ring aryl and condensed aromatic heterocycle substituent; r is a straight chain or branched chain alkyl of C1-C20; r' is a straight chain or branched chain alkyl of C1-C10.
The invention has the beneficial effects that: the invention starts from easily obtained diaryl 1, 2-diketone, has mild and green reaction conditions, does not need precious transition metal catalysis, is economic and environment-friendly, and has higher practicability.
Detailed Description
The technical solutions of the present invention will be described clearly and completely with reference to the following embodiments of the present invention, and it should be understood that the described embodiments are only a part of the embodiments of the present invention, and not all of the embodiments. All other embodiments, which can be obtained by a person skilled in the art without inventive effort based on the embodiments of the present invention, are within the scope of the present invention.
Example 1
Preparation of ethyl 2, 2-diphenylacetate (2 a):
Figure 602352DEST_PATH_IMAGE007
the specific synthesis steps and the characterization are as follows:
benzil 1a (21 mg, 0.1 mmol, 1.0 equiv.) and P (OEt) were combined in a 10 ml Schlenk tube3(33.2 mg, 0.2mmol, 2.0 equiv.) was dissolved in DCE (1.0 ml), EtOH (11.7. mu.L, 0.2mmol, 2.0 equiv.) and photocatalyst DPZ (0.0354 mg, 0.1. mu. mol) were added, the reaction was stirred for 48 hours under 3W LED (450 nm) irradiation at room temperature, and the reaction was completed by TLC. The reaction solution was concentrated under reduced pressure, and the residue was separated by silica gel column chromatography (volume ratio, the same applies hereinafter, PE: EA = 20: 1) to give the diaryl acetate compound 2a, 21.5 mg, 90%.
1H NMR (300 MHz, Chloroform-d) δ 7.41 – 7.23 (m, 10H), 5.04 (s, 1H),4.24 (q,J= 7.1 Hz, 2H), 1.28 (t,J= 7.1 Hz, 3H)。
13C NMR (75 MHz, CDCl3) δ 172.44, 138.80, 128.59, 128.54, 127.18,61.15, 57.16, 14.12; HRMS (ESI) m/z 241.1226 (M+H+), calc. for C6H17O2241.1223。
Using the procedure of example 1, varying the reaction conditions, the results are shown in the following table:
Figure 588630DEST_PATH_IMAGE009
example 2
Preparation of ethyl 2, 2-bis (4-butylphenyl) acetate (2 b):
Figure DEST_PATH_IMAGE010
the specific synthesis steps and the characterization are as follows:
benzil compound 1b (32.2 mg, 0.1 mmol, 1.0 equiv.) and P (OEt) were combined in a 10 ml Schlenk tube3(33.2 mg, 0.2mmol, 2.0 equiv.) was dissolved in DCE (1.0 ml), EtOH (11.7. mu.L, 0.2mmol, 2.0 equiv.) and photocatalyst DPZ (0.0354 mg, 0.1. mu. mol) were added, the reaction was stirred for 48 hours under 3W LED (450 nm) irradiation at room temperature, and the reaction was completed by TLC. The reaction solution was concentrated under reduced pressure, and the residue was separated by silica gel column chromatography (volume ratio, the same applies hereinafter, PE: EA = 20: 1) to give a diaryl acetate compound 2b, 27 mg, 77%.
1H NMR (300 MHz, Chloroform-d) δ 7.14 (d,J= 7.9 Hz, 4H), 7.04 (d,J= 8.0 Hz, 4H), 4.86 (s, 1H), 4.11 (q,J= 7.1 Hz, 2H), 2.49 (t,J= 7.7 Hz,4H), 1.55 – 1.43 (m, 4H), 1.33 – 1.22 (m, 4H), 1.17 (t,J= 7.1 Hz, 3H), 0.83(t,J= 7.3 Hz, 6H)。
13C NMR (75 MHz, CDCl3) δ 172.9, 141.7, 136.2, 128.7, 128.6, 128.4,128.4, 61.1, 56.5, 35.3, 33.5, 22.4, 14.2, 14.0；HRMS (ESI) m/z 353.2480 (M+H+), calc. for C24H33O2353.2475。
Example 3
Preparation of ethyl 2, 2-bis (4-chlorophenyl) acetate (2 c):
Figure 145513DEST_PATH_IMAGE011
the specific synthesis steps and the characterization are as follows:
benzil compound 1c (27.9 mg, 0.1 mmol, 1.0 equiv.) and P (OEt) were combined in a 10 ml Schlenk tube3(33.2 mg, 0.2mmol, 2.0 equiv.) was dissolved in DCE (1.0 ml), EtOH (11.7. mu.L, 0.2mmol, 2.0 equiv.) and photocatalyst DPZ (0.0354 mg, 0.1. mu. mol) were added, the reaction was stirred for 48 hours under 3W LED (450 nm) irradiation at room temperature, and the reaction was completed by TLC. The reaction mixture was concentrated under reduced pressure, and the residue was separated by silica gel column chromatography (volume ratio, the same applies hereinafter, PE: EA = 20: 1) to give a diarylacetate compound 2c, 22 mg, 71%。
1H NMR (300 MHz, Chloroform-d) δ 7.30 (d,J= 8.6 Hz, 4H), 7.22 (d,J= 8.6 Hz, 4H), 4.94 (s, 1H), 4.21 (q,J= 7.1 Hz, 2H), 1.26 (t,J= 7.1 Hz,3H)。
13C NMR (75 MHz, CDCl3) δ 171.8, 136.8, 133.4, 129.9, 128.8, 61.5,55.8, 14.1；HRMS (ESI) m/z 309.0445 (M+H+), calc. for C16H15Cl2O2309.0444。
Example 4
Preparation of ethyl 2, 2-bis (4-fluorophenyl) acetate (2 d):
Figure 68339DEST_PATH_IMAGE013
the specific synthesis steps and the characterization are as follows:
benzil compound 1d (24.6 mg, 0.1 mmol, 1.0 equiv.) and P (OEt) were combined in a 10 ml Schlenk tube3(33.2 mg, 0.2mmol, 2.0 equiv.) was dissolved in DCE (1.0 ml), EtOH (11.7. mu.L, 0.2mmol, 2.0 equiv.) and photocatalyst DPZ (0.0354 mg, 0.1. mu. mol) were added, the reaction was stirred for 48 hours under 3W LED (450 nm) irradiation at room temperature, and the reaction was completed by TLC. The reaction solution was concentrated under reduced pressure, and the residue was separated by silica gel column chromatography (volume ratio, the same applies hereinafter, PE: EA = 20: 1) to give a diaryl acetate compound 2d, 13 mg, 47%.
1H NMR (300 MHz, Chloroform-d) δ 7.26 (dd,J= 8.4, 5.6 Hz, 4H), 7.01(t,J= 8.7 Hz, 4H), 4.95 (s, 1H), 4.20 (q,J= 7.1 Hz, 2H), 1.25 (t,J= 7.2Hz, 3H)。
13C NMR (75 MHz, CDCl3) δ 172.2, 163.7, 160.4, 134.4, 134.4, 130.1,130.0, 115.7, 115.4, 77.4, 77.0, 76.6, 61.4, 55.5, 14.1；HRMS (ESI) m/z277.1033 (M+H+), calc. for C16H15F2O2277.1035。
Example 5
Preparation of ethyl 2, 2-bis (3-methoxyphenyl) acetate (2 e):
Figure DEST_PATH_IMAGE014
the specific synthesis steps and the characterization are as follows:
benzil compound 1e (27 mg, 0.1 mmol, 1.0 equiv.) and P (OEt) were combined in a 10 ml Schlenk tube3(33.2 mg, 0.2mmol, 2.0 equiv.) was dissolved in DCE (1.0 ml), EtOH (11.7. mu.L, 0.2mmol, 2.0 equiv.) and photocatalyst DPZ (0.0354 mg, 0.1. mu. mol) were added, the reaction was stirred for 48 hours under 3W LED (450 nm) irradiation at room temperature, and the reaction was completed by TLC. The reaction solution was concentrated under reduced pressure, and the residue was separated by silica gel column chromatography (volume ratio, the same shall apply hereinafter, PE: EA = 20: 1) to give the diaryl acetate compound 2e, 13 mg, 43%.
1H NMR (300 MHz, Chloroform-d) δ 7.23 (t,J= 7.8 Hz, 2H), 6.95 –6.83 (m, 4H), 6.80 (dd,J= 8.3, 2.5 Hz, 2H), 4.95 (s, 1H), 4.21 (q,J= 7.1Hz, 2H), 3.77 (s, 6H), 1.26 (t,J= 7.2 Hz, 3H)。
13C NMR (75 MHz, CDCl3) δ 172.2, 159.7, 140.0, 129.5, 121.0, 114.5,112.5, 61.2, 57.0, 55.2, 14.2；HRMS (ESI) m/z 301.1437 (M+H+), calc. forC18H21O4301.1434。
Example 6
Preparation of ethyl 2, 2-bis (2-fluorophenyl) acetate (2 f):
Figure DEST_PATH_IMAGE016
the specific synthesis steps and the characterization are as follows:
benzil compound 1f (24.6 mg, 0.1 mmol, 1.0 equiv.) and P (OEt) were combined in a 10 ml Schlenk tube3(33.2 mg, 0.2mmol, 2.0 equiv.) was dissolved in DCE (1.0 ml), EtOH (11.7. mu.L, 0.2mmol, 2.0 equiv.) and photocatalyst DPZ (0.0354 mg, 0.1. mu. mol) were added, and the mixture was irradiated with a 3W LED (450 nm) at room temperature, followed by stirring and reacting for 48 hoursIn hours, the reaction was complete by TLC. The reaction solution was concentrated under reduced pressure, and the residue was separated by silica gel column chromatography (volume ratio, the same applies hereinafter, PE: EA = 20: 1) to give a diaryl acetate compound 2f, 16 mg, 58%.
1H NMR (300 MHz, Chloroform-d) δ 7.33 – 7.14 (m, 4H), 7.14 – 6.96 (m,4H), 5.53 (s, 1H), 4.23 (q,J= 7.1 Hz, 2H), 1.24 (t,J= 7.1 Hz, 3H)。
13C NMR (75 MHz, CDCl3) δ 171.2, 162.2, 159.0, 130.0, 130.0, 129.3,129.2, 124.9, 124.7, 124.2, 124.2, 115.7, 115.4, 61.6, 43.4, 14.1；HRMS (ESI)m/z 277.1035 (M+H+), calc. for C16H15F2O2277.1035。
Example 7
Preparation of ethyl 2, 2-bis (2-chlorophenyl) acetate (2 g):
Figure DEST_PATH_IMAGE018
the specific synthesis steps and the characterization are as follows:
in a 10 ml Schlenk tube, 1g (27.9 mg, 0.1 mmol, 1.0 equiv.) of a benzil compound and P (OEt)3(33.2 mg, 0.2mmol, 2.0 equiv.) was dissolved in DCE (1.0 ml), EtOH (11.7. mu.L, 0.2mmol, 2.0 equiv.) and photocatalyst DPZ (0.0354 mg, 0.1. mu. mol) were added, the reaction was stirred for 48 hours under 3W LED (450 nm) irradiation at room temperature, and the reaction was completed by TLC. The reaction solution was concentrated under reduced pressure, and the residue was separated by silica gel column chromatography (volume ratio, the same applies hereinafter, PE: EA = 20: 1) to obtain 2g, 21.6 mg, 70% of the diarylacetate compound.
1H NMR (300 MHz, Chloroform-d) δ 7.48 – 7.35 (m, 2H), 7.23 (td,J=7.4, 6.5, 3.6 Hz, 4H), 7.13 – 7.02 (m, 2H), 5.81 (s, 1H), 4.25 (q,J= 7.1Hz, 2H), 1.26 (t,J= 7.1 Hz, 3H)。
13C NMR (75 MHz, CDCl3) δ 171.4, 135.3, 134.7, 129.8, 129.8, 128.8,126.9, 61.6, 51.7, 14.1.；HRMS (ESI) m/z 309.0446 (M+H+), calc. for C16H15Cl2O2309.0444。
Example 8
Preparation of ethyl 2, 2-bis (3-trifluoromethylphenyl) acetate (2 h):
Figure DEST_PATH_IMAGE020
the specific synthesis steps and the characterization are as follows:
benzil compound 1h (34.6 mg, 0.1 mmol, 1.0 equiv.) and P (OEt) in a 10 ml Schlenk tube3(33.2 mg, 0.2mmol, 2.0 equiv.) was dissolved in DCE (1.0 ml), EtOH (11.7. mu.L, 0.2mmol, 2.0 equiv.) and photocatalyst DPZ (0.0354 mg, 0.1. mu. mol) were added, the reaction was stirred for 48 hours under 3W LED (450 nm) irradiation at room temperature, and the reaction was completed by TLC. The reaction solution was concentrated under reduced pressure, and the residue was separated by silica gel column chromatography (volume ratio, the same applies hereinafter, PE: EA = 20: 1) to give a diaryl acetate compound 2h, 19 mg, 50%.
1H NMR (300 MHz, Chloroform-d) δ 7.48 – 7.35 (m, 2H), 7.23 (td,J=7.4, 6.5, 3.6 Hz, 4H), 7.13 – 7.02 (m, 2H), 5.81 (s, 1H), 4.25 (q,J= 7.1Hz, 2H), 1.26 (t,J= 7.1 Hz, 3H)。
13C NMR (75 MHz, CDCl3) δ 171.4, 135.3, 134.7, 129.8, 129.8, 128.8,126.9, 61.6, 51.7, 14.1.；HRMS (ESI) m/z 377.0977 (M+H+), calc. for C18H15F6O2377.0971。
The above description is only for the purpose of illustrating the preferred embodiments of the present invention and is not to be construed as limiting the invention, and any modifications, equivalents, improvements and the like that fall within the spirit and principle of the present invention are intended to be included therein.

Claims (10)

1.一种二芳基乙酸酯类化合物的制备方法，其特征在于步骤如下：1. a preparation method of diaryl acetate compound, is characterized in that step is as follows: （1）将二芳基1，2-二酮类化合物、醇类化合物、亚磷酸三烷基酯和光催化剂加入反应器皿中，加入溶剂溶解得到反应液；(1) adding diaryl 1,2-diketone compounds, alcohol compounds, trialkyl phosphite and photocatalyst into the reaction vessel, adding a solvent to dissolve to obtain a reaction solution; （2）利用光源照射反应液并搅拌至反应完全；(2) Irradiate the reaction solution with a light source and stir until the reaction is complete; （3）反应完成后，减压回收溶剂及柱层析纯化，得到二芳基乙酸酯类化合物。(3) After the reaction is completed, the solvent is recovered under reduced pressure and purified by column chromatography to obtain a diaryl acetate compound. 2.根据权利要求1所述的二芳基乙酸酯类化合物的制备方法，其特征在于，所述步骤（1）中二芳基1，2-二酮类化合物的结构式如下：
Figure 823590DEST_PATH_IMAGE001
，其中Ar1和Ar2相同或不同，选自苯基、取代苯基、芳杂环、稠环芳基、稠芳杂环取代基中的任意一种。2 . The preparation method of diaryl acetate compounds according to claim 1 , wherein the structural formula of the diaryl 1,2-diketone compounds in the step (1) is as follows: 2 .
Figure 823590DEST_PATH_IMAGE001
, wherein Ar 1 and Ar 2 are the same or different, and are selected from any one of phenyl, substituted phenyl, aromatic heterocycle, fused ring aryl, and fused aromatic heterocycle substituents. 3.根据权利要求1所述的二芳基乙酸酯类化合物的制备方法，其特征在于，所述步骤（1）中醇类化的结构式为ROH，其中R为C1-C20的直链或支链烷基。3. The preparation method of diaryl acetate compounds according to claim 1, wherein the structural formula of alcoholization in the step (1) is ROH, wherein R is a straight chain or branched chain of C1-C20 Alkyl. 4.根据权利要求1所述的二芳基乙酸酯类化合物的制备方法，其特征在于，步骤（1）中光催化剂的结构式如下：
Figure DEST_PATH_IMAGE002
。4 . The preparation method of diaryl acetate compounds according to claim 1 , wherein the structural formula of the photocatalyst in step (1) is as follows: 5 .
Figure DEST_PATH_IMAGE002
. 5.根据权利要求1所述的二芳基乙酸酯类化合物的制备方法，其特征在于：步骤（1）中亚磷酸三烷基酯的结构式为P（OR＇）3，其中R＇为C1-C10的直链或支链烷基。5. The preparation method of diaryl acetate compounds according to claim 1, wherein the structural formula of the trialkyl phosphite in step (1) is P(OR') 3 , wherein R' is C1 -C10 straight or branched chain alkyl. 6.根据权利要求1所述的二芳基乙酸酯类化合物的制备方法，其特征在于：所述步骤（1）中溶剂为乙腈、丙腈、异丙基腈、正丁腈、异丁基腈、叔丁基腈、二氯甲烷、二氯乙烷、氯仿、四氯化碳、苯、甲苯、乙苯、对二甲苯、乙醚、THF、二氧六环、二甲氧基乙烷中的任意一种。6. The preparation method of diaryl acetate compounds according to claim 1, wherein the solvent in the step (1) is acetonitrile, propionitrile, isopropyl nitrile, n-butyronitrile, isobutyl nitrile Nitrile, tert-butyl nitrile, dichloromethane, dichloroethane, chloroform, carbon tetrachloride, benzene, toluene, ethylbenzene, p-xylene, ether, THF, dioxane, dimethoxyethane any of the . 7.根据权利要求1-6任一项所述的二芳基乙酸酯类化合物的制备方法，其特征在于：所述步骤（1）中二芳基1，2-二酮类化合物、醇类化合物、亚磷酸三烷基酯和光催化剂的摩尔比为1:（1-10）：（1-3）：（0.001-0.1），反应液中二芳基1，2-二酮类化合物的浓度为0.01-1.0M。7 . The method for preparing diaryl acetate compounds according to claim 1 , wherein in the step (1), diaryl 1,2-diketone compounds, alcohols The molar ratio of compound, trialkyl phosphite and photocatalyst is 1:(1-10):(1-3):(0.001-0.1), the concentration of diaryl 1,2-diketone compounds in the reaction solution is 0.01-1.0M. 8.根据权利要求7所述的二芳基乙酸酯类化合物的制备方法，其特征在于：所述步骤（2）中光源为CFL灯泡、太阳光、或LED灯，CFL灯泡功率范围9-100W，LED灯波长范围445-455nm，功率1-10W。8 . The method for preparing a diaryl acetate compound according to claim 7 , wherein in the step (2), the light source is a CFL bulb, sunlight, or an LED lamp, and the power range of the CFL bulb is 9-100W. 9 . , LED light wavelength range 445-455nm, power 1-10W. 9.根据权利要求7所述的二芳基乙酸酯类化合物的制备方法，其特征在于：所述步骤（2）中反应过程利用氩气或氮气进行保护，反应时间为2-7天。9 . The method for preparing a diaryl acetate compound according to claim 7 , wherein in the step (2), the reaction process is protected by argon or nitrogen, and the reaction time is 2-7 days. 10 . 10.权利要求8或9所述的制备方法制备的二芳基乙酸酯类化合物，其特征在于结构式如下：10. the diaryl acetate compound that the preparation method described in claim 8 or 9 prepares, it is characterized in that structural formula is as follows:
Figure 927681DEST_PATH_IMAGE003
，其中Ar1和Ar2相同或不同，选自苯基、取代苯基、芳杂环、稠环芳基、稠芳杂环取代基；R为C1-C20的直链或支链烷基。
Figure 927681DEST_PATH_IMAGE003
, wherein Ar 1 and Ar 2 are the same or different, and are selected from phenyl, substituted phenyl, aromatic heterocycle, fused ring aryl, and fused aromatic heterocycle substituent; R is a C1-C20 straight-chain or branched-chain alkyl group.
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