CN110975003A - Antibiotic bone cement for treating orthopedic infection - Google Patents
Antibiotic bone cement for treating orthopedic infection Download PDFInfo
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- CN110975003A CN110975003A CN201911406993.1A CN201911406993A CN110975003A CN 110975003 A CN110975003 A CN 110975003A CN 201911406993 A CN201911406993 A CN 201911406993A CN 110975003 A CN110975003 A CN 110975003A
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- Prior art keywords
- bone cement
- polymethyl methacrylate
- antibiotic
- dextran
- tobramycin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L24/00—Surgical adhesives or cements; Adhesives for colostomy devices
- A61L24/001—Use of materials characterised by their function or physical properties
- A61L24/0015—Medicaments; Biocides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L24/00—Surgical adhesives or cements; Adhesives for colostomy devices
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L24/00—Surgical adhesives or cements; Adhesives for colostomy devices
- A61L24/001—Use of materials characterised by their function or physical properties
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L24/00—Surgical adhesives or cements; Adhesives for colostomy devices
- A61L24/04—Surgical adhesives or cements; Adhesives for colostomy devices containing macromolecular materials
- A61L24/06—Surgical adhesives or cements; Adhesives for colostomy devices containing macromolecular materials obtained by reactions only involving carbon-to-carbon unsaturated bonds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
- A61L2300/404—Biocides, antimicrobial agents, antiseptic agents
- A61L2300/406—Antibiotics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
- A61L2300/45—Mixtures of two or more drugs, e.g. synergistic mixtures
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/60—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a special physical form
- A61L2300/602—Type of release, e.g. controlled, sustained, slow
Abstract
The invention discloses an antibiotic bone cement for treating orthopedic infection, which comprises the following main components: polymethyl methacrylate, vancomycin, tobramycin and dextran. According to the invention, dextran is added into the original polymethyl methacrylate, so that vacuoles in a cured substance are increased, the release of antibiotics can be promoted, but the mechanical property is reduced, the mechanical property of bone cement can be enhanced though bubbles are reduced by adopting vacuum stirring, the effect that the mechanical property and the release rate of the antibiotics are relatively moderate can be realized by combining the vacuum stirring and the dextran, and then vancomycin and tobramycin are respectively added at two sides, so that the antibiotics can be released at the use position by matching the two antibiotics, the anti-infection capability is improved, the antibacterial spectrum is expanded by the combination of the two antibiotics, the drug resistance is reduced, and the application prospect is certain.
Description
Technical Field
The invention relates to the field of antibiotic bone cement, in particular to antibiotic bone cement for treating orthopedic infection.
Background
The bone cement is a common name of bone cements, the bone cement is a medical material used for orthopedic surgery, the antibiotic cement is a bone cement which is added with antibiotics to achieve the effects of preventing infection and treating infection after artificial joint replacement, and when the existing antibiotic bone cement is used, the antibiotic bone cement is possibly excellent in mechanical property, but not convenient for releasing the antibiotic or excellent in antibiotic release, but poor in mechanical property, and the anti-infection capacity of the bone cement is improved by adding a single antibiotic, but pathogenic bacteria have certain drug resistance, so that the single antibiotic is used for a long time, the anti-infection capacity is reduced, and the bone cement is susceptible to infection.
Disclosure of Invention
The invention aims to overcome the defects in the prior art, provides the antibiotic bone cement for treating orthopedic infection, and can effectively solve the problems in the background technology.
In order to achieve the purpose, the invention provides the following technical scheme: an antibiotic bone cement for treating orthopedic infection comprises the following main components: polymethyl methacrylate, vancomycin, tobramycin and dextran, wherein the ratio of the main components is 82 percent of polymethyl methacrylate, 8 percent of vancomycin, 8 percent of tobramycin and 2 percent of dextran.
Preferably, the monomer of the polymethyl methacrylate is methyl methacrylate, and the polymethyl methacrylate has lower density than glass, higher mechanical strength, lower melting point and higher light transmittance.
Preferably, the vancomycin has good antibacterial effect on most gram-positive bacteria such as methicillin-sensitive and drug-resistant strains, various streptococci, streptococcus pneumoniae and enterococci in staphylococcus including staphylococcus aureus and coagulase-negative staphylococcus.
Preferably, the tobramycin is a white to off-white hygroscopic powder chemical that binds at the 30S and 50S binding sites, hindering the formation of the 70S complex, rendering mRNA non-translatable into protein, resulting in cell death.
Preferably, the dextran is a polysaccharide composed of glucose groups, chemically inert and resistant to autoclaving.
Preferably, the preparation method of the antibiotic bone cement comprises the following steps:
(1) melting polymethyl methacrylate at high temperature, adding dextran into the melted polymethyl methacrylate, stirring by a vacuum stirrer, and introducing into a corresponding periosteum tool to prepare bone cement with a corresponding shape;
(2) after cooling, forming small holes on two sides of the bone cement, and respectively adding vancomycin antibiotic and tobramycin antibiotic into the holes on the two sides;
(3) after the addition is finished, taking liquid polymethyl methacrylate to block the open pores, solidifying the liquid polymethyl methacrylate by adopting local high-temperature heating, and sealing the antibiotics in the bone cement;
(4) and finishing the preparation of the antibiotic bone cement.
Compared with the prior art, the invention has the beneficial effects that:
the dextran is added into the original polymethyl methacrylate, so that the vacuoles in the cured substance are increased, the release of the antibiotics can be promoted, but the mechanical property is reduced, the bubbles are reduced by adopting vacuum stirring, the mechanical property of the bone cement can be enhanced, the effect that the mechanical property and the release rate of the antibiotics are relatively moderate can be realized by combining the vacuum stirring with the dextran, and then the vancomycin and the tobramycin are respectively added at two sides, so that the antibiotics can be released at the use position by matching the two antibiotics, the anti-infection capability is improved, the antibacterial spectrum is enlarged by combining the two antibiotics, the drug resistance is reduced, and the use of people is facilitated.
Drawings
FIG. 1 is an overall process flow diagram of the antibiotic bone cement for treating orthopedic infection of the present invention.
Detailed Description
In order to make the technical means, the creation characteristics, the achievement purposes and the effects of the invention easy to understand, the invention is further described with the specific embodiments.
In the description of the present invention, it should be noted that the terms "upper", "lower", "inner", "outer", "front", "rear", "both ends", "one end", "the other end", and the like indicate orientations or positional relationships based on those shown in the drawings, and are only for convenience of description and simplicity of description, but do not indicate or imply that the referred device or element must have a specific orientation, be constructed in a specific orientation, and be operated, and thus, should not be construed as limiting the present invention. Furthermore, the terms "first" and "second" are used for descriptive purposes only and are not to be construed as indicating or implying relative importance.
In the description of the present invention, it is to be noted that, unless otherwise explicitly specified or limited, the terms "mounted," "disposed," "connected," and the like are to be construed broadly, such as "connected," which may be fixedly connected, detachably connected, or integrally connected; can be mechanically or electrically connected; they may be connected directly or indirectly through intervening media, or they may be interconnected between two elements. The specific meanings of the above terms in the present invention can be understood in specific cases to those skilled in the art.
The technical solutions in the embodiments of the present invention will be clearly and completely described below with reference to the drawings in the embodiments of the present invention, and it is obvious that the described embodiments are only a part of the embodiments of the present invention, and not all of the embodiments. All other embodiments, which can be derived by a person skilled in the art from the embodiments given herein without making any creative effort, shall fall within the protection scope of the present invention.
Example 1
An antibiotic bone cement for treating orthopedic infection comprises the following main components: polymethyl methacrylate, vancomycin, tobramycin and dextran, wherein the ratio of the main components is 82 percent of polymethyl methacrylate, 8 percent of vancomycin, 8 percent of tobramycin and 2 percent of dextran.
Further, the monomer of the polymethyl methacrylate is methyl methacrylate, the density of the polymethyl methacrylate is lower than that of glass, the mechanical strength is higher, the melting point is lower, the light transmittance is higher, and the relevant properties of the polymethyl methacrylate are explained.
Furthermore, the vancomycin has good antibacterial effect on most gram-positive bacteria such as methicillin sensitive and resistant strains, various streptococci, streptococcus pneumoniae, enterococcus and the like in staphylococcus including staphylococcus aureus and coagulase negative staphylococcus, and explains the relevant properties of the vancomycin.
Further, tobramycin is a white to off-white hygroscopic powder chemical that binds at the binding site of 30S and 50S, hindering the formation of the 70S complex, rendering mRNA non-translatable into protein, resulting in cell death, and elucidating the relevant properties of tobramycin.
Furthermore, the polysaccharide formed by the dextran glucose group has inactive chemical property and can resist autoclaving, and the related properties of the dextran are explained.
Further, the preparation method of the antibiotic bone cement comprises the following steps:
(1) melting polymethyl methacrylate at high temperature, adding dextran into the melted polymethyl methacrylate, stirring by a vacuum stirrer, and introducing into a corresponding periosteum tool to prepare bone cement with a corresponding shape;
(2) after cooling, forming small holes on two sides of the bone cement, and respectively adding vancomycin antibiotic and tobramycin antibiotic into the holes on the two sides;
(3) after the addition is finished, taking liquid polymethyl methacrylate to block the open pores, solidifying the liquid polymethyl methacrylate by adopting local high-temperature heating, and sealing the antibiotics in the bone cement;
(4) and finishing the preparation of the antibiotic bone cement.
The dextran is added into the original polymethyl methacrylate, so that the vacuoles in the cured substance are increased, the release of the antibiotics can be promoted, but the mechanical property is reduced, the bubbles are reduced by adopting vacuum stirring, the mechanical property of the bone cement can be enhanced, the effect that the mechanical property and the release rate of the antibiotics are relatively moderate can be realized by combining the vacuum stirring with the dextran, the vancomycin and the tobramycin are respectively added at two sides, the antibiotics can be released at the use position by matching the two antibiotics, the anti-infection capacity is improved, the antibacterial spectrum is expanded by the combination of the two antibiotics, and the drug resistance is reduced
Although embodiments of the present invention have been shown and described, it will be appreciated by those skilled in the art that changes, modifications, substitutions and alterations can be made in these embodiments without departing from the principles and spirit of the invention, the scope of which is defined in the appended claims and their equivalents.
Claims (6)
1. An antibiotic bone cement for treating orthopedic infection is characterized in that the antibiotic bone cement for treating orthopedic infection comprises the following main components: polymethyl methacrylate, vancomycin, tobramycin and dextran, wherein the ratio of the main components is 82 percent of polymethyl methacrylate, 8 percent of vancomycin, 8 percent of tobramycin and 2 percent of dextran.
2. The antibiotic bone cement for treating orthopedic infections according to claim 1, wherein the monomer of the polymethyl methacrylate is methyl methacrylate, and the polymethyl methacrylate has lower density than glass, higher mechanical strength, lower melting point and higher light transmittance.
3. The antibiotic bone cement for treating orthopedic infection according to claim 1, wherein vancomycin has good antibacterial effect against methicillin-sensitive and resistant strains of staphylococcus including staphylococcus aureus and coagulase-negative staphylococcus, and a plurality of gram-positive bacteria such as various streptococci, streptococcus pneumoniae and enterococci.
4. An antibiotic bone cement for the treatment of orthopedic infections according to claim 1, wherein tobramycin is a white to off-white hygroscopic powder chemical attached at the 30S and 50S attachment site that blocks the formation of 70S complex, rendering mRNA unable to be translated into protein, resulting in cell death.
5. The antibiotic bone cement for treating bone infection according to claim 1, wherein the dextran glucose based polysaccharide is chemically inert and resistant to autoclaving.
6. Antibiotic bone cement for the treatment of orthopaedic infections according to any of claims 1 to 5, characterized in that it is prepared by a process comprising the following steps:
(1) melting polymethyl methacrylate at high temperature, adding dextran into the melted polymethyl methacrylate, stirring by a vacuum stirrer, and introducing into a corresponding periosteum tool to prepare bone cement with a corresponding shape;
(2) after cooling, forming small holes on two sides of the bone cement, and respectively adding vancomycin antibiotic and tobramycin antibiotic into the holes on the two sides;
(3) after the addition is finished, taking liquid polymethyl methacrylate to block the open pores, solidifying the liquid polymethyl methacrylate by adopting local high-temperature heating, and sealing the antibiotics in the bone cement;
(4) and finishing the preparation of the antibiotic bone cement.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201911406993.1A CN110975003A (en) | 2019-12-31 | 2019-12-31 | Antibiotic bone cement for treating orthopedic infection |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201911406993.1A CN110975003A (en) | 2019-12-31 | 2019-12-31 | Antibiotic bone cement for treating orthopedic infection |
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| Publication Number | Publication Date |
|---|---|
| CN110975003A true CN110975003A (en) | 2020-04-10 |
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| Application Number | Title | Priority Date | Filing Date |
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| CN201911406993.1A Pending CN110975003A (en) | 2019-12-31 | 2019-12-31 | Antibiotic bone cement for treating orthopedic infection |
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Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1768867A (en) * | 2004-10-07 | 2006-05-10 | 贺利氏古萨有限公司 | PPMA(polymethyl methacrylate) bone cement containing antibiotic |
| CN101229391A (en) * | 2007-01-26 | 2008-07-30 | 贺利氏古萨有限公司 | Revision polymethyl methacrylate bone cement |
-
2019
- 2019-12-31 CN CN201911406993.1A patent/CN110975003A/en active Pending
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1768867A (en) * | 2004-10-07 | 2006-05-10 | 贺利氏古萨有限公司 | PPMA(polymethyl methacrylate) bone cement containing antibiotic |
| CN101229391A (en) * | 2007-01-26 | 2008-07-30 | 贺利氏古萨有限公司 | Revision polymethyl methacrylate bone cement |
Non-Patent Citations (4)
| Title |
|---|
| HUGH S. BROCK等: "Compression Strength and Porosity of Single-Antibiotic Cement Vacuum-Mixed With Vancomycin", 《THE JOURNAL OF ARTHROPLASTY》 * |
| MURRAY J. PENNER等: "Elution Characteristics of Vancomycin and Tobramycin Combined in Acrylic Bone-Cement", 《THE JOURNAL OF ARTHROPLASTY》 * |
| 张先龙等主编: "《人工关节感染》", 31 October 2008, 上海科学技术出版社 * |
| 杨骐宁: "抗生素骨水泥的药释特性和增效思路", 《中华关节外科杂志( 电子版)》 * |
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Application publication date: 20200410 |
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