CN1109742A - Toothpaste for health of cardio-cerebral blood vessel - Google Patents
Toothpaste for health of cardio-cerebral blood vessel Download PDFInfo
- Publication number
- CN1109742A CN1109742A CN 94115209 CN94115209A CN1109742A CN 1109742 A CN1109742 A CN 1109742A CN 94115209 CN94115209 CN 94115209 CN 94115209 A CN94115209 A CN 94115209A CN 1109742 A CN1109742 A CN 1109742A
- Authority
- CN
- China
- Prior art keywords
- toothpaste
- health
- medicine
- heart
- cerebrovascular
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Landscapes
- Cosmetics (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
The health-care toothpaste for cardiac and cerebral blood vessels contains the drug for preventing and curing cardiovascular and cerebrovascular diseases and ordinary toothpaste as basic matter.
Description
The present invention relates to a kind of heart, cerebrovascular health-care toothpaste and its production and application.
Present medicated toothpaste mainly is treatment and prevention oral disease, and topical therapeutic does not then have effective means of prevention for the heart, cerebrovascular disease often.
The present invention is intended to change traditional route of administration: selection one or two kind of medicine, be mixed in proportion in toothpaste,, reach the prevention sudden death by 2～3 times on the one this natural daily life modes of brushing teeth, the various coronary heart disease of prophylactic treatment, the purpose of hypertension and multiple diseases related thereof.The clinical observation of inventor by recent two decades, on probation, this health-care toothpaste is to the control heart, very convenient, the safety of cerebrovascular disease, effect is remarkable, make thousands of middle age, old people avoid sudden death, cardiac muscle is more filled in and apoplexy, and can be used to prevent and treat bronchial asthma etc., its social benefit is extremely huge.
The present invention's's " heart, cerebrovascular health-care toothpaste " principle is as follows:
(1) allows medicine extensively contact by brushing teeth, absorb rapidly with oral mucosa.Oral mucosa is very thin, and has a large amount of blood capillaries and the shallow vein of table to distribute, and blood circulation is abundant, but the medicine oral transmucosal that only has minority to be soluble in lipid absorbs.Medicament mixed is in toothpaste, and the through port transmucosal absorbs, and absorbs by the intestines and stomach than oral drugs, and the effective blood concentration that reaches is faster, absorb fully manyly.But the medicament mixed of a past people control tooth and oral disease is prevented and treated local disease in toothpaste.And " heart, cerebrovascular health-care toothpaste " is that the nifedipine or sorbitrate or the 654-2 etc. that generally acknowledge in the world at present are mixed in the toothpaste.By rise morning and sleep before this life necessary process of brushing teeth, within 2～3 minutes, absorbed by oral mucosa rapidly, and can remain valid blood concentration for 4～5 hours.This is the same with injection, oral drugs, can play the effect of whole body administration, be particularly useful for preventing and treating hypertension, hypertensive crisis, coronary heart disease particular significant effect, simultaneously also can prevent bronchial asthma, primary pulmonary hypertension, Raynaud phenomenon, diseases such as stomach, intestinal, gallbladder, renal colic and prevention of migraine, dysmenorrhea.This is a kind of innovation to whole body multisystem disease comprehensive prevention, treatment medication.Will inevitably find that from now on the efficient medicine that more absorbs rapidly from oral mucosa adds the toothpaste, become serial health toothpaste, this innovation administering mode is further developed.
(2) " heart, cerebrovascular health-care toothpaste " Chinese medicine absorbs and pharmacology:
" heart, cerebrovascular health-care toothpaste " if in the drug main nifedipine.This is a kind of yellow crystal powder, and is water-soluble hardly, and odorless, tasteless has fat-soluble characteristics, can be rapidly, fully the through port transmucosal is absorbed into blood.Be the health care good medicine of a kind of universally acknowledged action range, determined curative effect, rapid-action, duration of efficacy is long, side effect is few prevention, treatment angina pectoris, asthma, hypertension, gallbladder, renal colic, gastrointestinal convulsion.This medicine is a calcium ion antagonist, can suppress myocardial contraction and reduce myocardial oxygen consumption, but do not suppress the heart pump function, also significantly coronary artery dilator (its to the coronary artery smooth muscle effect than surplus the verapamil strong ten times, the periphery arterial smooth muscle also there is remarkable effect), coronary blood flow increasing, promoting side to prop up circulation sets up, further improve the blood supply in myocardial ischemia district, prevent angina pectoris attacks, or the consumption of minimizing attack times, mitigation symptoms and minimizing nitroglycerin, increase exercise tolerance, improve the ischemia electrocardiogram.Especially effective to the invalid clinostatism angina pectoris of nitroglycerin class.Simultaneously, because the reflexive sympathetic activation, heart rate is increased with, myocardial contraction strengthen.So no flesh suppresses phenomenon after the medication, thereby can increase left chamber dp/dt and cardiac output, life-time service does not have metabolic to accumulate.
This medicine also can see through blood brain barrier, reaches expansion of cerebral vascular and improves cerebral blood circulation, and treatment is because of the cerebral blood supply insufficiency due to the cerebral arteriosclerosis.
This medicine C capable of blocking
aDesignated lane suppresses the coupling of air pipe smooth muscle contraction, and smooth muscle is loose as a result, and this merges pulmonary heart disease for coronary heart disease asthma person, not only can prevent and treat angina pectoris, and can remove asthma attack.
Small artery vascular resistance around this medicine can reduce distends the blood vessels, can bring high blood pressure down effectively (diastolic pressure descends more obvious than systolic pressure), thereby lightening heart load.This medicine of prolonged application can reduce various types of hypertension (no matter Secondary cases or constitutional) and treatment hypertensive crisis.
The heart of the present invention, cerebrovascular health-care toothpaste are substrate with general toothpaste, add medicine, especially nifedipine and/or the sorbitrate and/or the 654-2 of the preventing/treating heart, cerebrovascular in substrate, preferably add nifedipine.
In the health-care toothpaste of the present invention, contain 100 milligrams of said medicine, especially nifedipines and/or sorbitrate and/or 654-2, preferred nifedipine in per 100 gram toothpaste.
The prevention and health care amount was brushed teeth 3-5 minute with 0.5 gram (about 0.5 centimeter length) toothpaste at every turn, promptly equaled the treatment that patient has accepted 5 milligrams of/time doses.Use as treatment, consumption also can be decided according to hypertension, coronary heart disease, bronchial asthma patient's state of an illness weight.If the toothpaste with 1.0～2.0 grams (i.e. 1～2 centimeter length) was brushed teeth 3-5 minute, promptly equaled to use 10～20 milligrams/time nifedipine therapeutic dose.
In addition, fine because of lucifuge, the sealing of toothpaste, avoided medicine under high light He in the air, to decompose fully.
The present invention's's " heart, cerebrovascular health-care toothpaste " advantage is as follows:
(1) do not have any abnormal flavour, foreign odor, it is nice and cool that mouthfeel is fresh and sweet, selection to include pharmaceutical properties stable, can be, and life-time service do not have addiction, toleration, also do not have depot action because of the expire delay treatment.Medicine has the sealing of toothpaste lucifuge, but long preservation, the medicine source is abundant, and cost is humble, really is: inexpensive.
(2) sleep preceding, be engaged in social activity or travelling after getting up, brushing teeth is the orbit program, as long as used " heart, cerebrovascular health-care toothpaste " to brush teeth 3～5 minutes, can reach 85% by blood drug level within 2～3 minutes, and can keep 4～5 hours.Play the whole body administration, the effect of myocardial infarction, sudden death, apoplexy, angina pectoris, bronchial asthma and other multiple diseases of prevention burst.Two getting at one stroke, is the Perfect Companion and the reliable bodyguard of middle-aged and elderly people daily life, tourism in fact.
The present invention's " heart, cerebrovascular health-care toothpaste " changes the routine of original medicine coated tablet oral administration, removes and sucks not easy disintegrating, slow, (band medicine) burden of taking medicine of absorption.It is blended in medicine in the toothpaste equably, reaches the purpose of whole body administration by brushing teeth.This accords with traditional hygienic habit of the civilized daily life that the million people forms decades fully.Need not remind, very natural and regular.Immeasurable effect is played in commonly encountered diseases, frequently-occurring disease-hypertension, angina pectoris attacks, myocardial infarction and the sudden death of preventing, control middle-aged and elderly people.
The present invention's " heart, cerebrovascular health-care toothpaste " compared with prior art has the following advantages, characteristics and good effect:
1. " heart, cerebrovascular health-care toothpaste " meets the daily life rule by the teeth brushing way administration:
Every Christian that self care ability is arranged, get up the back and the sleep before brush teeth be living-hygienic must do problem, for elderly people, like this everyday, year in and year out, needn't remind to have become trained reflex, be difficult to forget, and people also will never also be considered as burden brushing teeth as loaded down with trivial details minor matter.So, as long as patient has used " heart, cerebrovascular health-care toothpaste ", that just equals to have used the control heart, cerebrovascular medicine in after getting up and sleeping five hours.Administration is very natural, practical, safety, reliable.
2. fast, the length of holding time of the drug absorption in " heart, cerebrovascular health-care toothpaste ":
In general people are 3～5 minutes at time of brushing teeth, this has surpassed " heart, cerebrovascular health-care toothpaste " Chinese medicine and has absorbed required time from oral mucosa, by brush teeth, medicine extensively contacts with oral mucosa equably, add that Borneolum Syntheticum in the toothpaste can promote medicine to absorb rapidly within 2～3 minutes, and concentration that can be in blood is the longest kept five hours.
3. medicine is not destroyed by gastrointestinal, absorbs not influenced by digestive system:
Common oral drugs will absorb by gastrointestinal, if gastrointestinal dysfunction such as vomiting, diarrhoea, the retention of gastric appearance etc. all can influence the absorption of medicine, simultaneously pipe intestinal digesting enzyme and acid, alkali all can destroy the part medicine, and some people's gastrointestinal tract can not tolerate the stimulation of medicine.But just can avoid above-mentioned drawback fully with " heart, cerebrovascular health-care toothpaste ", and the medicine oral transmucosal directly enters systemic circulation after absorbing, also can avoid oral and be subjected to through portal vein that liver is destructive to be influenced.
4. " heart, cerebrovascular health-care toothpaste " overcome the custom of the irregular medication of large quantities of patients:
Many 35～55 years old hypertension and/or the angor patient that just makes up one's mind, they shoulder heavy responsibilities in social every profession and trade, at first are busy with work all day, and are social frequent, overwork and emotional excitement very easily take place and sudden cardiovascular and cerebrovascular diseases; Secondly most cerebrovascular patients that just make up one's mind do not form medicine not from body with by the custom of Times medicine, go out especially outside to forget in work or the travelling way and take medicine.Can not use if having medicine on hand again during morbidity, myocardial infarction, apoplexy even sudden death can take place when being in a bad way; Moreover, a considerable amount of people is not enough to the sudden and high risk of cardiovascular and cerebrovascular disease understanding, often prevention and therapeutic is taken medicine and regards burden as, he can not adheres to for a long time, take medicine on time.Yet patient is as long as brush teeth with " heart, cerebrovascular health-care toothpaste ", just equals for a long time, the rule medication.
5. " heart, cerebrovascular health-care toothpaste " comes out and reduces the incidence rate of hypertension, apoplexy and heart infarction sudden death surely greatly:
According to the sick magazine of american heart nineteen ninety about increasing the Epidemiological study report of sudden cardiac death the morning, propose the mortality myocardial infarction and betide the morning: sudden cardiac death is the morning 6～9 o'clock and 9～11 o'clock main rush hour, this is relevant with ergasia increase myocardial ischemia with muscle power, the back is as long as brushed tooth with " heart, cerebrovascular health-care toothpaste " but these people get up early morning, their blood drug level just can be kept about 4～5 hours, and that will avoid or reduce greatly the incidence rate of hypertension, apoplexy, angina pectoris heart infarction, sudden death.
The present invention's's " heart, cerebrovascular health-care toothpaste " prevention and health care scope:
1. various types of angina pectoriss and myocardial infarction: especially rest angina pectoris behind the patient that fails to respond to any medical treatment of nitrate preparations and beta-blocker and anomaly unstable angina, the acute myocardial infarction and serious angina of effort.
2. all kinds hypertension: various secondary hypertensions and hypertension, hypertensive crisis.
3. can be used to treat achalasia of the cardia, diffuse esophageal spasm, radiation esophagitis, peptic ulcer, acute edematous pancreatitis, gastrointestinal convulsion, the acute vomiting and diarrhoea of traveller, gallbladder, renal colic according to reports, medicine in the health-care toothpaste also can reduce portal vein pressure in addition, the treatment portal hypertension.The intractable stomachache of irritable bowel syndrome, ulcerative colitis, advanced liver cancer, the vomiting due to the hyperfunction syndrome of vagus nerve also there is certain curative effect.
The production technology of health-care toothpaste of the present invention as shown in Figure 1.Comprising technologies such as batching, mixing, kneading, dosing, grindings.The raw material that adopts in this technology all is that this area professional is known as wetting agent, foaming agent, binding agent, spice, abrasive etc.
To illustrate health-care toothpaste of the present invention below, cited embodiment only is used to illustrate the present invention, and unrestricted its scope.
Embodiment 1
Component content (weight %)
Alumina hydrate 40
Carboxymethyl cellulose 2
Laurel alcohol radical sodium sulfate 2
Glycerol 20
Sorbitol 10
Saccharin sodium 0.5
Essence 1.0
Silica sol 6.5
Nifedipine 1.0
Water adds to 100%.
Embodiment 2
Component content (weight %)
Alumina hydrate 40
Carboxymethyl cellulose 2
Laurel alcohol radical sodium sulfate 2
Glycerol 20
Sorbitol 10
Saccharin sodium 0.5
Essence 1.0
Silica sol 3.0
Sorbitrate 1.0
Water adds to 100%.
Embodiment 3
Component content (weight %)
Alumina hydrate 40
Carboxymethyl cellulose 2
Laurel alcohol radical sodium sulfate 2
Glycerol 20
Sorbitol 10
Saccharin sodium 0.5
Essence 1.0
Silica sol 1.8
654-2 1.0
Water adds to 100%.
Claims (8)
1, the heart, cerebrovascular health-care toothpaste wherein contain the medicine that prevents and/or treats the heart, cerebrovascular, and general toothpaste is as substrate.
2, according to the health-care toothpaste of claim 1, the medicine that wherein prevents and/or treats the heart, cerebrovascular is selected from one or more among nifedipine, sorbitrate and the 654-2.
3, according to the health-care toothpaste of claim 1, the content of medicine in 100 gram toothpaste that wherein prevents and/or treats the heart, cerebrovascular is 100 milligrams.
4, according to the health-care toothpaste of claim 2, the medicine that wherein prevents and/or treats the heart, cerebrovascular is selected from nifedipine.
5, according to the health-care toothpaste of claim 2, the medicine that wherein prevents and/or treats the heart, cerebrovascular is selected from sorbitrate.
6, according to the health-care toothpaste of claim 2, the medicine that wherein prevents and/or treats the heart, cerebrovascular is selected from 654-2.
7, the using method of the health-care toothpaste of claim 3 as prophylactic applications, is used 0.5 gram at every turn, brushes teeth 3-5 minute.
8, the using method of the health-care toothpaste of claim 3 is used as treatment, uses the 1.0-2.0 gram at every turn, brushes teeth 3-5 minute.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 94115209 CN1109742A (en) | 1994-09-22 | 1994-09-22 | Toothpaste for health of cardio-cerebral blood vessel |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 94115209 CN1109742A (en) | 1994-09-22 | 1994-09-22 | Toothpaste for health of cardio-cerebral blood vessel |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN1109742A true CN1109742A (en) | 1995-10-11 |
Family
ID=5037411
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN 94115209 Pending CN1109742A (en) | 1994-09-22 | 1994-09-22 | Toothpaste for health of cardio-cerebral blood vessel |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN1109742A (en) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6846478B1 (en) | 1998-02-27 | 2005-01-25 | The Procter & Gamble Company | Promoting whole body health |
| US8277782B2 (en) | 2000-06-30 | 2012-10-02 | The Procter & Gamble Company | Topical oral care compositions comprising host response modulating agents |
-
1994
- 1994-09-22 CN CN 94115209 patent/CN1109742A/en active Pending
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6846478B1 (en) | 1998-02-27 | 2005-01-25 | The Procter & Gamble Company | Promoting whole body health |
| US8277782B2 (en) | 2000-06-30 | 2012-10-02 | The Procter & Gamble Company | Topical oral care compositions comprising host response modulating agents |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| US5204118A (en) | Pharmaceutical compositions and methods for treating the symptoms of overindulgence | |
| Graves et al. | Martorell’s hypertensive leg ulcer: case report and concise review of the literature | |
| CN101287457A (en) | Use of treprostinil to treat neuropathic diabetic foot ulcers | |
| US5248505A (en) | Method for treating gastrointestinal distress | |
| CN1627951A (en) | Compositions and method for prophylaxis and treatment of aphthous ulcers and herpes simplex lesions | |
| IE64953B1 (en) | Use of a composition for the manufacture of a medicament for curing the symptoms of overindulgence | |
| CN105582028A (en) | Use of antrodia camphorata for treating diseases | |
| JPH02237929A (en) | N-acetyl glucosamine as cell protection medicine | |
| US6703370B1 (en) | Use of ribose to treat fibromyalgia | |
| CN1109742A (en) | Toothpaste for health of cardio-cerebral blood vessel | |
| US6835398B2 (en) | Method of administering high-dose, oral magnesium for treatment of chronic pain syndrome of erythromelalgia | |
| Galinsky et al. | Evaluation of activated charcoal-sodium sulfate combination for inhibition of acetaminophen absorption and repletion of inorganic sulfate | |
| CN1259939C (en) | Traditional Chinese medicine formulation for oral disease and its preparation method | |
| CN110935002A (en) | Composition with blood pressure lowering effect and application thereof | |
| CN101066399A (en) | Chinese medicine prepn for treating recurrent aphtha | |
| EP1095658A2 (en) | Use of ribose to treat fibromyalgia | |
| US20040192781A1 (en) | Method of administration for metoclopramide and pharmaceutical formulation therefor | |
| RU2357747C1 (en) | Method of psoriatic disease treatment | |
| CN102940671B (en) | Medicine composition for treating diabetic foot | |
| CN1180775C (en) | Compound stomatocase-treating capsule | |
| Segal et al. | A polyamine formaldehyde resin IV. Clinical evaluation in the treatment of duodenal ulcer | |
| JP2002201135A (en) | Composition for epigastrium comprising lactulose | |
| CN1112204C (en) | Traditional Chinese powder medicine for treating cough and preparation process thereof | |
| CN1176688C (en) | Medicine for treating acute and chronic pharyngitis and its prepn | |
| CN1176667C (en) | Medicine for treating gastrosis and enteropathy and its preparing process |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| C06 | Publication | ||
| PB01 | Publication | ||
| C01 | Deemed withdrawal of patent application (patent law 1993) | ||
| WD01 | Invention patent application deemed withdrawn after publication |