CN110960626A - Traditional Chinese medicine composition for promoting intimal growth and application thereof - Google Patents

Traditional Chinese medicine composition for promoting intimal growth and application thereof Download PDF

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Publication number
CN110960626A
CN110960626A CN201911301935.2A CN201911301935A CN110960626A CN 110960626 A CN110960626 A CN 110960626A CN 201911301935 A CN201911301935 A CN 201911301935A CN 110960626 A CN110960626 A CN 110960626A
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Prior art keywords
root
medicine composition
rhizome
traditional chinese
chinese medicine
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林喧
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Guangzhou Xiaowa Pharmaceutical Technology Co Ltd
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Guangzhou Xiaowa Pharmaceutical Technology Co Ltd
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    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/80Scrophulariaceae (Figwort family)
    • A61K36/804Rehmannia
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Abstract

The invention relates to a traditional Chinese medicine composition, in particular to a traditional Chinese medicine composition for promoting intimal growth and application thereof, wherein the traditional Chinese medicine composition comprises prepared rehmannia root, figwort root, immature bitter orange, white paeony root, Chinese thorowax root, honey-fried licorice root, nutgrass galingale rhizome, Chinese angelica, Szechuan lovage rhizome, cassia bark, dwarf lilyturf tuber, asparagus root, fructus cannabis, Chinese date, donkey-hide gelatin, Chinese wolfberry, American ginseng, manyflower solomonseal rhizome, eucommia bark, south dodder seed, membranous milkvetch root, glossy privet fruit, yerbadetajo herb, largehead atractylodes rhizome, Indian buead, oriental waterplantain rhizome, cherokee rose fruit, dogwood fruit, longan pulp, tangerine peel and maltose Patients with abortion and habitual abortion.

Description

Traditional Chinese medicine composition for promoting intimal growth and application thereof
Technical Field
The invention relates to a traditional Chinese medicine composition, in particular to a traditional Chinese medicine composition for promoting intimal growth and application thereof.
Background
The inner membrane is thin due to environmental pollution, mental stress, the influence of working environment and living irregularity, and undernourishment caused by shaping is emphasized; during artificial abortion and hysteroscopy, the operation is related to such as uterus dilatation, release of adhesion, electrocision, excision of submucosal myoma and the like; peeling off the inner membrane after natural abortion, and the like; the rapid hyperplasia and repair of the intima is an important link for preventing adhesion and a premise that the re-pregnancy can be performed as soon as possible, and meanwhile, the too thin intima is also an important reason for the failure of assisted reproduction.
Disclosure of Invention
The invention aims to provide a traditional Chinese medicine composition for promoting intimal growth and application thereof, which overcome the defects of the prior art, are used for patients with thin plain intima after dialectical treatment or patients with thin intima caused by hysteroscopy, human (drug) abortion and natural abortion, and can effectively reduce the use of hormone medicines, thereby effectively reducing side effects, promoting intimal growth, increasing conception probability, improving the success rate of assisted reproduction, improving infant embracing rate, simultaneously tonifying qi and blood, building body, strengthening body, being beneficial to the overall recovery of organisms, and also being used for patients with unstable fetus, abortion, habitual abortion and the like caused by deficiency of qi and blood.
In order to achieve the purpose, the invention provides a traditional Chinese medicine composition for promoting intimal growth and application thereof.
A traditional Chinese medicine composition for promoting intimal growth and application thereof are disclosed, wherein the traditional Chinese medicine composition comprises the following components in grams by weight: 30 g of prepared rhizome of rehmannia, 30 g of dried rehmannia root, 30 g of figwort root, 20 g of immature bitter orange, 30 g of white paeony root, 30 g of Chinese thorowax root, 50 g of prepared licorice root, 30 g of nutgrass galingale rhizome, 30 g of Chinese angelica, 30 g of szechuan lovage rhizome, 15 g of cassia bark, 30 g of dwarf lilyturf tuber, 30 g of asparagus, 20 g of fructus cannabis, 50 g of Chinese date, 50 g of donkey-hide gelatin, 30 g of medlar, 30 g of American ginseng, 30 g of rhizoma polygonati, 30 g of eucommia bark, 30 g of dodder, 50 g of astragalus root, 30 g of glossy privet fruit, 30 g of eclipta alba, 20 g of largehead atractylodes rhizome, 20 g of Indian buead, 20 g of oriental.
The preparation method of the traditional Chinese medicine composition comprises the following steps:
soaking: sorting fine medicinal materials, cleaning, packaging into clean cloth bag, placing into stainless steel barrel, soaking in cold water, and continuously turning over the medicinal bag; the soaking standard is based on no hard center of medicinal decoction pieces pinched by hands, and the medicinal decoction pieces need to be soaked for 2-4 hours in autumn and more than 6 hours in winter;
decocting: putting the soaked medicinal materials and the liquid medicine into a medicine decocting machine, adding a proper amount of water, and decocting for 2 times, wherein the circulation is performed for 1 hour at 100 ℃ each time; during the decoction period, the extrusion rod is rotated for many times, so that the effective ingredients of the medicinal materials are fully dissolved; mixing the two decoctions, and standing for 24 hr;
concentration: concentrating the supernatant, adding maltose adjuvant, and stirring; decocting Ginseng radix and radix Codonopsis for 2-4 hr, mixing the decoction with the above concentrated solution, and sieving the concentrated solution with 200 mesh sieve;
subpackaging: concentrating the filtered medicinal liquid, adding colla Corii Asini fine powder solution, stirring, and collecting ointment until the ointment is flag-hanging in winter and silk-hanging in summer, and the relative density of the ointment is 1.4-1.45; pouring the collected soft extract into a clean paste packaging machine for subpackage;
cooling the paste: and (4) moving the packaged paste prescription to a paste cooling room for natural cooling, and cooling to a state that the hands are not hot.
The functions and effects of the medicinal materials in the invention are as follows:
prepared rhizome of rehmannia: sweet and slightly warm in taste; entering liver and kidney meridians; nourishing yin and enriching blood; it is indicated for deficiency of yin and blood, atrophy and weakness of waist and knees, fatigue, cough, steaming bone, seminal emission, metrorrhagia, menoxenia, diabetes, scanty urine, deafness and blurred vision.
Radix rehmanniae: sweet, slightly warm; enter liver and kidney meridians, nourish blood and yin, supplement essence and fill marrow; can be used for treating blood deficiency, sallow complexion, cardiopalmus, menoxenia, metrorrhagia, metrostaxis, deficiency of liver-yin and kidney-yin, soreness of waist and knees, hectic fever, night sweat, nocturnal emission, internal heat, diabetes, giddiness, tinnitus, and early white beard and hair.
Figwort root: sweet, bitter, salty and slightly cold in taste; spleen, stomach and kidney meridians entered; clearing heat and cooling blood; nourishing yin to reduce pathogenic fire; detoxify, dissipate stagnation and warm disease heat entering nutrient blood; fever; polydipsia; a deep-red tongue; carrying out spot formation; bone steaming, strain cough; restlessness due to deficiency in the middle energizer; constipation due to body fluid impairment; eyes are astringent and dim; swollen and sore throat; scrofula and subcutaneous nodule; abscess, deep-rooted carbuncle and sore.
Immature bitter orange: bitter, pungent, sour and slightly cold in taste; spleen and stomach meridians entered; break qi and remove food retention, resolve phlegm and disperse mass; can be used for treating stagnation, abdominal distention, pain, dysentery, constipation, phlegm stagnation, qi stagnation, thoracic obstruction, and viscera prolapse.
White peony root: bitter and sour taste, slightly cold nature; entering liver and spleen meridians; nourishing blood, regulating menstruation, astringing yin, arresting sweating, softening liver, relieving pain, and suppressing liver yang; can be used for treating blood deficiency, sallow complexion, menoxenia, spontaneous perspiration, night sweat, hypochondriac pain, abdominal pain, limb spasm pain, headache, and vertigo.
Bupleurum root: pungent and bitter in flavor and slightly cold in nature; entering liver, gallbladder and lung meridians; harmonizing exterior and interior, soothing liver-qi stagnation, lifting yang and sinking, allaying fever and checking malaria; can be used for treating common cold, fever, alternating chills and fever, distending pain in chest and hypochondrium, menoxenia, uterine prolapse, and proctoptosis.
Honey-fried licorice root: warm in nature and sweet in taste; the heart meridian, the lung meridian, the stomach meridian and the spleen meridian; nourish yin and blood, tonify qi and activate yang, recover pulse and stop palpitation.
Rhizoma cyperi: pungent, slightly bitter, slightly sweet and mild; entering liver, spleen and triple energizer meridians; soothing liver and relieving qi stagnation, regulating qi and relieving epigastric distention, regulating menstruation and relieving pain, and can be used for treating stagnation of qi due to liver-qi, distending pain in chest and hypochondrium, hernia pain, breast pain, qi stagnation in spleen and stomach, abdominal distention and fullness, distention and pain, menoxenia, and amenorrhea and dysmenorrhea.
Chinese angelica: sweet and pungent in flavor and warm in nature; it enters liver, heart and spleen meridians; enriching blood, promoting blood circulation, regulating menstruation, relieving pain, loosening bowel to relieve constipation; can be used for treating blood deficiency, sallow complexion, giddiness, cardiopalmus, menoxenia, amenorrhea, dysmenorrhea, asthenia cold abdominal pain, rheumatalgia, traumatic injury, superficial infection, pyocutaneous disease, intestinal dryness, and constipation; the wine angelica is capable of activating blood and stimulating menstrual flow; can be used for treating amenorrhea, dysmenorrhea, rheumatalgia, and traumatic injury.
Ligusticum wallichii: pungent and warm taste; the liver, gallbladder and pericardium channels are responsible for activating blood and promoting qi circulation, and removing wind and relieving pain; it can be used for treating amenorrhea, abdominal pain, headache, general pain, and rheumatism.
Cinnamon: pungent and sweet in flavor and strong in heat; entering kidney, spleen, heart and liver meridians; has the effects of tonifying fire, supporting yang, guiding fire to the origin, dispelling cold, relieving pain, and warming and dredging channels and collaterals; can be used for treating sexual impotence, cold womb, cold pain of waist and knee, asthma due to kidney deficiency, floating of deficient yang, giddiness, conjunctival congestion, cold pain of heart and abdomen, vomiting and diarrhea due to deficiency cold, cold hernia, abdominal pain, dysmenorrhea, and amenorrhea.
Radix ophiopogonis: sweet, slightly bitter and slightly cold; entering heart, lung and stomach meridians; nourishing yin, promoting the production of body fluid, moistening lung and relieving cough: can be used for treating deficiency of body fluid, thirst, dry cough, and hemoptysis due to yin deficiency of lung and stomach; palpitation due to heart yin deficiency and body fluids injured by heat in the late stage of fever; it is combined with Sha Shen and Chuan Bei mu to treat dry cough due to lung yin deficiency.
Asparagus: sweet, bitter and cold in nature; entering lung and kidney meridians; nourishing yin, moistening dryness, clearing lung-heat, and promoting fluid production; can be used for treating dry cough due to lung dryness, cough with sticky phlegm, soreness of waist and knees, hectic fever due to yin-deficiency, internal heat, thirst, dry throat, and constipation due to intestinal dryness.
Fructus cannabis: sweet in taste and neutral in nature; spleen, stomach and large intestine meridians entered; loosening bowel to relieve constipation; can be used for treating constipation due to intestinal dryness caused by blood deficiency and body fluid deficiency.
Chinese date: sweet and warm in taste; entering spleen and stomach meridians; invigorating spleen and regulating stomach function, benefiting qi and promoting fluid production, regulating yingfen and weifen, and removing drug toxicity; treating stomach deficiency, poor appetite, spleen weakness, loose stool, deficiency of qi, blood and body fluid, disharmony between ying and wei, palpitation; the women are dirty and manic.
E, donkey-hide gelatin: sweet and mild in taste; entering lung, liver and kidney meridians; nourishing yin and blood, preventing miscarriage; it is indicated for blood deficiency, cough due to asthenia, hematemesis, epistaxis, hematochezia, female irregular menstruation, metrorrhagia, fetal leakage.
Wolfberry fruit: sweet and mild in taste; entering liver and kidney meridians; nourishing kidney, moistening lung, nourishing liver, and improving eyesight; it is indicated for liver and kidney yin deficiency, soreness and weakness of waist and knees, dizziness, blurred vision, hyperdacryosis, cough due to asthenia, diabetes, and spermatorrhea.
American ginseng: cool in nature, sweet and slightly bitter in taste; entering heart, lung and kidney meridians; invigorating qi, nourishing yin, clearing away heat, and promoting salivation; can be used for treating deficiency of vital energy and yin, internal heat, cough, asthma, phlegm, asthenia, vexation, fatigue, diabetes, and dry mouth; benefiting lung yin, clearing deficient fire, promoting fluid production to quench thirst; it is indicated for chronic cough due to lung deficiency, blood loss, dry throat, thirst, deficiency heat, restlessness and fatigue.
Rhizoma polygonati: sweet in taste and neutral in nature; spleen, lung and kidney meridians entered; invigorating qi, nourishing yin, invigorating spleen, moistening lung, and invigorating kidney; can be used for treating deficiency of spleen-stomach qi, asthenia, stomach yin deficiency, xerostomia, cough with little appetite, lung deficiency, cough with excessive consumption, hemoptysis, essence and blood deficiency, soreness of waist and knees, premature gray hair, and internal heat with thirst quenching effect.
Eucommia ulmoides: pungent and mild in flavor; entering liver and kidney meridians; tonify liver and kidney, strengthen tendons and bones, prevent miscarriage; it is indicated for soreness and pain of lumbar and knees, atrophy and weakness of feet and knees, dribbling urination, itching of vulva, vaginal bleeding, threatened abortion, and hypertension.
Dodder seed: pungent, sweet and neutral in flavor; it enters liver, kidney and spleen meridians; tonifying liver and kidney, arresting seminal emission, reducing urination, preventing miscarriage, improving eyesight, and relieving diarrhea; dispel wind and remove spots for external use.
Astragalus root: sweet in flavor and slightly warm in nature; invigorating qi, consolidating superficial resistance, expelling toxin, expelling pus, promoting urination, and promoting granulation; can be used for treating deficiency of vital energy, asthenia, chronic diarrhea, proctoptosis, spontaneous perspiration, edema, uterine prolapse, albuminuria due to chronic nephritis, diabetes, and unhealed wound.
Glossy privet fruit: has mild nature, sweet and bitter taste, belongs to liver and kidney channels, and has the effects of nourishing yin, prolonging life, tonifying liver and kidney, clearing heat, improving eyesight, blackening hair and beard, and the like; it is commonly used to treat dizziness, tinnitus, blurred vision, soreness and pain of waist and knees, internal heat, and early graying of beard and hair.
Eclipta alba: sweet and sour in taste and cold in nature; entering kidney and liver meridian; nourishing liver and kidney, cooling blood and stopping bleeding; can be used for treating liver and kidney yin deficiency, odontoseisis, premature gray hair, giddiness tinnitus, soreness of waist and knees, yin deficiency, blood heat, hematemesis, epistaxis, hematuria, bloody dysentery, metrorrhagia, hemorrhage due to trauma.
White atractylodes rhizome: bitter, warm, pungent and strong in flavor; spleen and stomach meridians entered; invigorating qi and spleen, eliminating dampness and promoting diuresis, arresting sweating, and preventing miscarriage; can be used for treating spleen qi deficiency, anorexia, loose stool, phlegm retention, edema, exterior deficiency, spontaneous perspiration, and threatened abortion.
Tuckahoe, poria cocos: sweet and light taste, mild in nature; the heart, lung, spleen and kidney meridians are entered; promoting diuresis, eliminating dampness, invigorating spleen, and calming heart; can be used for treating edema, oliguria, phlegm and fluid retention, dizziness, palpitation, spleen deficiency, anorexia, loose stool, diarrhea, uneasiness, palpitation, and insomnia.
Rhizoma alismatis: sweet and light taste, cold in nature; entering kidney and bladder meridians; promoting diuresis, eliminating dampness, clearing heat, eliminating turbid pathogen and reducing blood lipid; can be used for treating dysuria, edema, abdominal distention, diarrhea, oliguria, phlegm retention, vertigo, pyretic stranguria, pain, and hyperlipidemia.
Cherokee rose fruit: sour, sweet, astringent and neutral in nature; entering kidney, bladder and large intestine meridians; secure essence and reduce urination, secure metrorrhagia and stop leukorrhagia, astringe intestines to check diarrhea; can be used for treating spermatorrhea, enuresis, frequent micturition, metrorrhagia, leukorrhagia, chronic diarrhea, and dysentery.
Cornus officinalis: sour, astringent and slightly warm in taste; entering liver and kidney meridians; tonify liver and kidney, astringe essence, strengthen deficiency; it is used for treating soreness of waist and knees, vertigo, tinnitus, sexual impotence, spermatorrhea, frequent micturition, liver deficiency, cold and heat, sweating, and heart shaking pulse powder.
Longan pulp: sweet taste and warm nature; heart and spleen meridians entered; tonifying heart and spleen, nourishing blood and tranquillizing; can be used for treating deficiency of both qi and blood, palpitation, amnesia, insomnia, blood deficiency, and sallow complexion.
Dried orange peel: bitter and pungent taste, warm in nature; entering lung and spleen meridians; regulating qi-flowing, invigorating spleen, eliminating dampness, and eliminating phlegm; can be used for treating abdominal distention, anorexia, vomiting, diarrhea, cough, and excessive phlegm.
Maltose: sweet and warm; entering spleen, stomach and lung meridians; relieving the middle energizer, tonifying deficiency, promoting the production of body fluid and moistening dryness; it is indicated for fatigue damaging spleen, tenesmus, abdominal pain, lung dryness cough, hematemesis, thirst, pharyngalgia, constipation.
Compared with the prior art, the invention has the advantages that: the traditional Chinese medicine composition regulates the functions of viscera, thoroughfare vessel and uterus by tonifying qi and blood, supporting yang, nourishing yin, filling kidney essence, nourishing liver blood, regulating thoroughfare vessel and tonifying uterus, promotes qi and blood generation, uterus recovery and endometrial growth, and is also beneficial to implantation and growth and development of embryos. Effectively promote the recovery of the organism and the hyperplasia and repair of the intima after the operation and the abortion. The medicines are matched to have good efficacies of tonifying qi and blood without retaining stasis, removing blood stasis without damaging healthy qi, promoting the recovery of human bodies after operations and abortion and accelerating the repair of the uterus and endometrium. The medicines are matched to well tonify qi and blood, and meanwhile, the spleen and the stomach are protected to promote transportation and transformation, so that the Chinese medicinal composition is tonifying without stagnation and nourishing without greasy.
Detailed Description
Typical cases are:
case 1, Wangzhi, age 35, female, recurrent abortion 4 times, thin intima after repeated uterine cleaning, B ultrasound (intima) thickness of 3-5mm, small menstrual amount, light color, and half-year pregnancy; plain is easy to feel tired and short breath, and seeks treatment; after the formula is continuously taken for 2 months and a period is finished, the ultrasonography B intima is thickened to 9mm, the symptoms such as increased menstrual flow, bright color, short breath and easy fatigue are obviously improved, the patient successfully receives pregnancy in the 3 rd month, the formula is continuously taken until 8 weeks of pregnancy, and then the patient returns to a hospital for continuous obstetric examination.
Case 2, easy to be cured, 31 years old, female, repeated hypogastrium and bulge in 5 cycles of pregnancy, and little vaginal bleeding to hospital; self-complaints are easy to cause chest distress, short breath, sleepiness, anorexia and spontaneous perspiration; the syndrome belongs to deficiency of both qi and blood; after the formula is taken, bleeding stops for one week, the feeling of tenesmus and distension is obviously relieved, and the medicine is stopped after the medicine is continuously taken for 12 weeks. No relevant symptoms appear during pregnancy, and the production is smooth.
Case 3, wangzhi, 37 years old, primary infertility, previous IVF-ET operation 5 times, none of which was implanted; the patients with liver and kidney deficiency are identified, and the transplantation is carried out again after the formula is continuously taken for 2 months, so that the implantation is successful; the formula is continuously taken until pregnancy lasts for 11 weeks, and then the pregnant woman returns to the hospital to continue the obstetrical examination.
The above embodiments are merely illustrative of the technical concept and features of the present invention, and the purpose thereof is to enable those skilled in the art to understand the content of the present invention and implement the invention, and not to limit the scope of the present invention, and all equivalent controls or modifications made according to the spirit of the main technical scheme of the present invention should be covered in the scope of the present invention.

Claims (3)

1. A traditional Chinese medicine composition for promoting intimal growth is characterized in that: the weight grams of the prescription of the traditional Chinese medicine composition are as follows: 30 g of prepared rhizome of rehmannia, 30 g of dried rehmannia root, 30 g of figwort root, 20 g of immature bitter orange, 30 g of white paeony root, 30 g of Chinese thorowax root, 50 g of prepared licorice root, 30 g of nutgrass galingale rhizome, 30 g of Chinese angelica, 30 g of szechuan lovage rhizome, 15 g of cassia bark, 30 g of dwarf lilyturf tuber, 30 g of asparagus, 20 g of fructus cannabis, 50 g of Chinese date, 50 g of donkey-hide gelatin, 30 g of medlar, 30 g of American ginseng, 30 g of rhizoma polygonati, 30 g of eucommia bark, 30 g of dodder, 50 g of astragalus root, 30 g of glossy privet fruit, 30 g of eclipta alba, 20 g of largehead atractylodes rhizome, 20 g of Indian buead, 20 g of oriental.
2. The traditional Chinese medicine composition for promoting intimal growth according to claim 1, which is characterized in that: the preparation method of the traditional Chinese medicine composition comprises the following steps:
soaking: sorting fine medicinal materials, cleaning, packaging into clean cloth bag, placing into stainless steel barrel, soaking in cold water, and continuously turning over the medicinal bag; the soaking standard is based on no hard center of medicinal decoction pieces pinched by hands, and the medicinal decoction pieces need to be soaked for 2-4 hours in autumn and more than 6 hours in winter;
decocting: putting the soaked medicinal materials and the liquid medicine into a medicine decocting machine, adding a proper amount of water, and decocting for 2 times, wherein the circulation is performed for 1 hour at 100 ℃ each time; during the decoction period, the extrusion rod is rotated for many times, so that the effective ingredients of the medicinal materials are fully dissolved; mixing the two decoctions, and standing for 24 hr;
concentration: concentrating the supernatant, adding maltose adjuvant, and stirring; decocting Ginseng radix and radix Codonopsis for 2-4 hr, mixing the decoction with the above concentrated solution, and sieving the concentrated solution with 200 mesh sieve;
subpackaging: concentrating the filtered medicinal liquid, adding colla Corii Asini fine powder solution, stirring, and collecting ointment until the ointment is flag-hanging in winter and silk-hanging in summer, and the relative density of the ointment is 1.4-1.45; pouring the collected soft extract into a clean paste packaging machine for subpackage;
cooling the paste: and (4) moving the packaged paste prescription to a paste cooling room for natural cooling, and cooling to a state that the hands are not hot.
3. Use of a Chinese medicinal composition according to claims 1-2 for the treatment of endometrial growth.
CN201911301935.2A 2019-12-17 2019-12-17 Traditional Chinese medicine composition for promoting intimal growth and application thereof Pending CN110960626A (en)

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Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1772203A (en) * 2005-10-17 2006-05-17 李亚萍 Chinese herbal medicine decoction for treating liver and kidney deficiency and blood stasis type endometriosis and its prepn
CN108404047A (en) * 2018-04-27 2018-08-17 云南省中医医院 A kind of Chinese medicine composition of the prevention postoperative adhesion again of Asherman's syndrom

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1772203A (en) * 2005-10-17 2006-05-17 李亚萍 Chinese herbal medicine decoction for treating liver and kidney deficiency and blood stasis type endometriosis and its prepn
CN108404047A (en) * 2018-04-27 2018-08-17 云南省中医医院 A kind of Chinese medicine composition of the prevention postoperative adhesion again of Asherman's syndrom

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
王泳晓,等: "氯米芬联合补肾助阳中药对诱导排卵周期中子宫内膜厚度的影响", 《中国医学创新》 *

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