CN110951691B - Anti-human TNF-alpha stable cell strain and construction method and application thereof - Google Patents
Anti-human TNF-alpha stable cell strain and construction method and application thereof Download PDFInfo
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- CN110951691B CN110951691B CN201911076644.8A CN201911076644A CN110951691B CN 110951691 B CN110951691 B CN 110951691B CN 201911076644 A CN201911076644 A CN 201911076644A CN 110951691 B CN110951691 B CN 110951691B
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- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
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Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
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CN102127167A (en) * | 2010-01-15 | 2011-07-20 | 苏州工业园区晨健抗体组药物开发有限公司 | Whole human TNF alpha (tumor necrosis factor alpha) monoclonal antibody and preparation and application thereof |
CN102167741A (en) * | 2010-02-25 | 2011-08-31 | 百迈博药业有限公司 | Fully human anti-TNF-alpha (Tumor Necrosis Factor-alpha) monoclonal antibody and preparation method as well as application thereof |
CN107236710A (en) * | 2017-03-27 | 2017-10-10 | 天津科技大学 | The stable anti-TNF alpha monoclonal antibodies cell expression system of expression |
CN108164601A (en) * | 2017-11-17 | 2018-06-15 | 安徽未名生物医药有限公司 | A kind of preparation method for recombinating the full human monoclonal antibody of anti-tnf-alpha |
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Patent Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN102127167A (en) * | 2010-01-15 | 2011-07-20 | 苏州工业园区晨健抗体组药物开发有限公司 | Whole human TNF alpha (tumor necrosis factor alpha) monoclonal antibody and preparation and application thereof |
CN102167741A (en) * | 2010-02-25 | 2011-08-31 | 百迈博药业有限公司 | Fully human anti-TNF-alpha (Tumor Necrosis Factor-alpha) monoclonal antibody and preparation method as well as application thereof |
CN107236710A (en) * | 2017-03-27 | 2017-10-10 | 天津科技大学 | The stable anti-TNF alpha monoclonal antibodies cell expression system of expression |
CN108164601A (en) * | 2017-11-17 | 2018-06-15 | 安徽未名生物医药有限公司 | A kind of preparation method for recombinating the full human monoclonal antibody of anti-tnf-alpha |
Non-Patent Citations (3)
Title |
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Antagonistic effect of peptidoglycan of Streptococcus sanguinis on lipopolysaccharide of major periodontal pathogens;Sung-Hoon Lee;《Journal of Microbiology》;20150731;第53卷(第8期);第553-560页 * |
抗人肿瘤坏死因子-α人源单克隆抗体在CHO细胞中的表达及鉴定;崔文禹;《中国生物制品学杂志》;20141231;第27卷(第12期);第1547-1550页 * |
治疗性抗体高表达CHO细胞株构建策略;李浩强;《中国医药生物技》;20130630;第8卷(第3期);第221页右栏第4段 * |
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