CN110947100B - Method for positioning and correcting magnetic stimulation beat optical fiber - Google Patents
Method for positioning and correcting magnetic stimulation beat optical fiber Download PDFInfo
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- CN110947100B CN110947100B CN201911326159.1A CN201911326159A CN110947100B CN 110947100 B CN110947100 B CN 110947100B CN 201911326159 A CN201911326159 A CN 201911326159A CN 110947100 B CN110947100 B CN 110947100B
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- A61N2/00—Magnetotherapy
- A61N2/004—Magnetotherapy specially adapted for a specific therapy
- A61N2/006—Magnetotherapy specially adapted for a specific therapy for magnetic stimulation of nerve tissue
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- A61B5/1455—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue using optical sensors, e.g. spectral photometrical oximeters
- A61B5/14551—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue using optical sensors, e.g. spectral photometrical oximeters for measuring blood gases
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Abstract
The invention discloses a method for positioning and correcting an optical fiber of a magnetic stimulation beat, which is characterized in that four optical fiber sections are arranged on the magnetic stimulation beat, the four optical fibers are uniformly arranged around a focusing point of the magnetic stimulation beat to construct 4 leads for near infrared detection, whether the absolute value of the blood oxygen concentration of the 4 leads meets a detection basic condition or not is judged by carrying out the near infrared detection on the 4 leads, whether the absolute value of the blood oxygen concentration of the 4 leads meets a limit condition or not is judged when the detection basic condition is met, if not, the position of the magnetic stimulation beat is adjusted according to the absolute value of the blood oxygen concentration until the absolute value of the blood oxygen concentration of the 4 leads meets the limit condition, and therefore, the optical fiber positioning and correcting of the magnetic stimulation beat are realized.
Description
Technical Field
The invention relates to the field of positioning correction of medical equipment, in particular to a method for positioning correction of a magnetic stimulation beat optical fiber.
Background
Transcranial Magnetic Stimulation (TMS) is a non-invasive therapeutic apparatus for exciting or inhibiting cerebral neurons, and is mainly used for treating nervous system diseases such as epilepsy, parkinson's disease, depression and insomnia. A stimulation beat in the transcranial magnetic stimulator adopts a high-strength coil, and pulse current of thousands of amperes is passed through the stimulation beat so as to produce magnetic field pulse with quick change around the stimulation beat, and the magnetic field can pass through scalp and skull of tested person without loss, and can act on cerebral cortex under the scalp to induce nerve cell to produce change of potential activity so as to induce some reactions of nerve cell excitation, muscle contraction and hormone secretion, etc.
The human brain is divided into a plurality of sub-regions with specialized functions, and in order to regulate the functional activity of a certain abnormal brain region without affecting other normal brain regions, the stimulation range of TMS is usually required to be focused on a smaller range. The transcranial magnetic field stimulation positioning cap has been reported in the prior art, however, the stimulation beat has a certain size, and is not transparent, and in actual operation, whether the corresponding position of the stimulation beat is aligned with the target position of the head or not cannot be confirmed. In general, when a line connecting a magnetic field focusing point of the stimulation beat and a target stimulation point of the head is perpendicular to the stimulation beat, the magnetic field pulse has the strongest stimulation to the target stimulation point of the head. However, in practice, the stimulation beat has a certain size, and a slight inclination may cause the connection line to be not perpendicular to the stimulation beat, i.e. the stimulation received by the target stimulation point becomes weaker.
The existing report provides a transcranial magnetic stimulation repositioning cutting sleeve, the shape of the inner edge of a coil cutting sleeve is set to be matched with the shape of the outer edge of an 8-shaped coil, and a positioning component for determining the central point of the coil cutting sleeve is arranged in the coil cutting sleeve. However, such a ferrule has the following problems: (1) The stimulation device is only suitable for the stimulation beat of the 8-shaped coil, however, the stimulation faces of the current many domestic stimulation beats are rectangular; (2) The problem that the connecting line between the magnetic field focusing point of the stimulation beat and the target stimulation point of the head cannot be always perpendicular to the stimulation beat in the working process at present still cannot be solved.
Because the head surface is similar to an ellipsoid, the contact target stimulation point is not a tangent head surface basically when the magnetic stimulation beat is used for stimulation treatment, namely the target stimulation point is accurate but the magnetic stimulation beat is not tangent to the head, the stimulation of the target stimulation point is not in place, and the difference exists between the target stimulation point and an ideal point. Whether the swatter is operated manually or operated by a manipulator, due to the fact that the size of human heads is different, although the target stimulation point is found, the deviation of the magnetic stimulation swatter is unknown, and whether a connecting line between a magnetic field focusing position of the magnetic stimulation swatter and the target stimulation point of the head is perpendicular to the magnetic stimulation swatter cannot be determined.
Disclosure of Invention
The invention aims to solve the problems in the prior art and provides a method for positioning and correcting a magnetic stimulation shooting optical fiber.
In order to achieve the purpose, the invention adopts the technical scheme that:
a method of magnetic stimulation beat fiber optic localization correction, the method comprising:
constructing 4 leads for near infrared detection by using four sections of optical fibers arranged on the magnetic stimulation beat;
performing near-infrared detection on the 4 leads to obtain An absolute value An of the blood oxygen concentration corresponding to each lead;
judging whether the absolute value An of the blood oxygen concentration of the 4 th channel meets a detection basic condition An which is not less than B, wherein n =1,2,3,4, B is the minimum effective value of the local blood oxygen concentration detected by near infrared;
when the detection basic conditions An is larger than or equal to B and n =1,2,3 and 4 are met, judging whether the absolute value of the blood oxygen concentration of 4 leads meets An = Bn +/-C, wherein Bn is the mean value of An, and C is An allowable error amount;
and when the absolute value of the blood oxygen concentration of the 4 leads does not satisfy An = Bn +/-C, adjusting the position of the magnetic stimulation beat according to the An value.
Preferably, one surface of the magnetic stimulation beat, which is close to the target stimulation point, is provided with four optical fibers, the four optical fibers are uniformly arranged around the focusing point of the magnetic stimulation beat, the two optical fibers are used as transmitting optical fibers, the two optical fibers are used as receiving optical fibers, and a line segment between the transmitting optical fibers and the receiving optical fibers is used as 1 lead for near-infrared detection.
Preferably, the four optical fibers are arranged around the focusing point of the magnetic stimulation beat in a square shape, wherein the two emitting optical fibers and the two receiving optical fibers are symmetrically arranged at the diagonal vertexes of the square shape, and the distance between the adjacent emitting optical fibers and the adjacent receiving optical fibers is 30mm.
Preferably, the method further comprises: when the absolute value of the blood oxygen concentration of the 4 leads does not satisfy An = Bn +/-C, the position of the magnetic stimulation beat is adjusted to the direction of smaller value of An.
Preferably, the magnetic stimulation beat starts the treatment procedure when the absolute value of the blood oxygen concentration of the 4 leads satisfies An = Bn ± C.
Preferably, during the magnetic stimulation beat treatment process, the absolute value of the blood oxygen concentration of the 4 leads is continuously detected in real time, and when the absolute value of the blood oxygen concentration of the 4 leads is not satisfied with An = Bn ± C, the position of the magnetic stimulation beat is finely adjusted in the direction in which the value of An is smaller.
Compared with the prior art, the invention has the beneficial effects that:
(1) The invention sets four sections of optical fiber sections on the magnetic stimulation beat, the four sections of optical fibers are uniformly arranged around the focusing point of the magnetic stimulation beat to construct 4 leads for near infrared detection, the 4 leads are subjected to near infrared detection to judge whether the absolute value of the blood oxygen concentration of the 4 leads meets the basic detection condition, when the basic detection condition is met, the absolute value of the blood oxygen concentration of the 4 leads is judged whether to meet the limiting condition, if not, the position of the magnetic stimulation beat is adjusted according to the absolute value of the blood oxygen concentration until the absolute value of the blood oxygen concentration of the 4 leads meets the limiting condition, thereby realizing the optical fiber positioning correction of the magnetic stimulation beat.
(2) The invention takes the line segment between the adjacent transmitting optical fiber and the receiving optical fiber as 1 guide to carry out near infrared detection to obtain the absolute value of the blood oxygen concentration of 4 guides, judges whether the absolute value of the blood oxygen concentration of 4 guides is in a limited range, realizes the positioning correction of the magnetic stimulation beat magnetic field focusing point by monitoring the absolute value of the blood oxygen concentration of 4 guides in real time, utilizes the absolute value of the blood oxygen concentration of 4 guides as a feedback signal in the process of diagnosis and treatment of the magnetic stimulation beat, monitors and adjusts the magnetic stimulation beat magnetic field focusing point in real time, leads the connecting line between the magnetic stimulation beat magnetic field focusing point and the head target stimulating point to be always vertical to the magnetic stimulation beat, and realizes the accurate positioning and the real-time correction of the magnetic stimulation beat.
Drawings
FIG. 1 is a schematic diagram of an arrangement of four optical fibers in a magnetic stimulation beat according to an embodiment of the present invention;
FIG. 2 is a flowchart of a method for calibrating the fiber positioning of a magnetic stimulation beat according to an embodiment of the present invention;
FIG. 3 is a schematic diagram of a magnetic stimulation beat in an ideal state according to an embodiment of the invention.
Detailed Description
The technical solutions of the present invention will be described clearly and completely with reference to the accompanying drawings, and it is obvious that the described embodiments are only some embodiments of the present invention, not all embodiments. All other embodiments, which can be derived by a person skilled in the art from the embodiments given herein without making any creative effort, shall fall within the protection scope of the present invention.
The invention provides a method for positioning and correcting an optical fiber of a magnetic stimulation beat, which is characterized in that four optical fiber sections are arranged on the magnetic stimulation beat, the four optical fibers are uniformly arranged around a focusing point of the magnetic stimulation beat to construct 4 leads for near infrared detection, whether the absolute value of the blood oxygen concentration of the 4 leads meets a detection basic condition or not is judged by carrying out the near infrared detection on the 4 leads, whether the absolute value of the blood oxygen concentration of the 4 leads meets a limit condition or not is judged when the detection basic condition is met, if not, the position of the magnetic stimulation beat is adjusted according to the absolute value of the blood oxygen concentration until the absolute value of the blood oxygen concentration of the 4 leads meets the limit condition, and therefore, the optical fiber positioning and correction of the magnetic stimulation beat are realized.
As shown in fig. 1, the method comprises the steps of:
step 1, four sections of optical fibers arranged on a magnetic stimulation beat are utilized to construct 4-lead for near infrared detection.
The magnetic stimulation beat is placed on the head target stimulation point, and the four sections of optical fibers are uniformly arranged around the focusing point of the magnetic stimulation beat. The two optical fibers are used as transmitting optical fibers, the two optical fibers are used as receiving optical fibers, and the line segment between the transmitting optical fibers and the receiving optical fibers is used as 1 guide for near infrared detection. The two ends of the transmitting optical fiber are oppositely arranged, the two ends of the receiving optical fiber are oppositely arranged, and the four sections of optical fibers construct 4-guide of near infrared detection.
Further, as shown in fig. 2, four optical fibers of the magnetic stimulation beat are arranged around the focus point of the magnetic stimulation beat in a square shape, wherein two transmitting optical fibers and two receiving optical fibers are symmetrically arranged at the diagonal vertices of the square shape, and the distance between the adjacent transmitting optical fibers and the adjacent receiving optical fibers is 30mm. That is, the length of 1 lead for near infrared detection is 30mm.
And 2, performing near infrared detection on the 4 leads to obtain An absolute value An of the blood oxygen concentration corresponding to each lead.
Specifically, the front ends of the four sections of optical fibers on the magnetic stimulation beat are in contact with the scalp around the target stimulation point, and the rear ends of the optical fibers are connected to the processing equipment through the magnetic stimulation beat so as to transmit the blood oxygen content detected by near infrared to the processing equipment for processing. A processing device herein refers to an apparatus, such as a computer, having data transmission, processing, and storage capabilities. In practical application, the magnetic stimulation beat can be connected with the optical fiber of the computer, the result of the near infrared blood oxygen concentration detection of the magnetic stimulation beat is transmitted to the computer through the optical fiber, and the absolute value of the blood oxygen concentration of the 4 leads is obtained after the computer processes the result.
And 3, judging whether the absolute value An of the blood oxygen concentration of the 4 leads meets a detection basic condition An which is not less than B, wherein n =1,2,3,4, B is the minimum effective value of the local blood oxygen concentration of the near infrared detection.
Specifically, after the computer and other processing devices process the 4 th absolute value of blood oxygen concentration, the 4 th absolute value of blood oxygen concentration An is compared with a preset detection basic condition, and whether the 4 th absolute value of blood oxygen concentration An meets the detection basic condition is determined. If yes, continuing the subsequent flow; if the absolute value of the blood oxygen concentration detected by the near infrared is not satisfied, the direction of the magnetic stimulation beat is adjusted to the direction with a smaller value of An on the premise of confirming that the positioning of the mechanical hand is accurate, because the distance between the optical fiber and the scalp is long, the absolute value of the blood oxygen concentration detected by the near infrared is low.
Further, the magnetic stimulation beat adjustment can realize automatic adjustment, namely, the value of the magnetic stimulation beat adjustment is recorded twice according to the trend, and the automatic adjustment is realized by adopting a difference method.
And 4, when the detection basic conditions An is not less than B and n =1,2,3 and 4 are met, judging whether the absolute value of the blood oxygen concentration of the 4 leads meets An = Bn +/-C, wherein Bn is the mean value of An and C is An allowable error amount.
Specifically, if An = Bn ± C is satisfied, where Bn is the mean of An and C is the allowable error amount, the magnetic stimulation beat may begin the treatment process; if not, the next step is continued. The trends of normal testing of near infrared detection are approximately similar, but the obtained absolute value difference is large, and the testing value can be selected according to the actual situation.
And 5, when the absolute value of the blood oxygen concentration of the 4 leads does not meet An = Bn +/-C, adjusting the position of the magnetic stimulation beat according to An value.
Further, when the absolute value of the blood oxygen concentration of the 4-lead does not satisfy An = Bn + -C, the position of the magnetic stimulation beat is adjusted in the direction that the value of An is smaller. In the adjustment process of the magnetic stimulation beat, the absolute value of the blood oxygen concentration of the 4 leads is monitored in real time, when the absolute value of the blood oxygen concentration of the 4 leads is monitored to meet An = Bn +/-C, the adjustment process is stopped, and the magnetic stimulation beat starts the treatment process.
Specifically, in the magnetic stimulation beat treatment process, if the absolute value of the blood oxygen concentration of 4 leads is changed due to the occurrence of the magnetic stimulation beat jitter, the limiting condition is not met any more, the magnetic stimulation beat can be finely adjusted towards the direction with the smaller value of An according to the data processing result, and the real-time positioning correction of the magnetic stimulation beat is realized. After the near infrared detection treatment is finished, the effectiveness of the treatment is detected by taking the blood oxygen concentration before and after the treatment as a reference.
The ideal state after the optical fiber positioning correction of the magnetic stimulation beat is shown in fig. 3, at this time, the connecting line between the magnetic field focusing point of the magnetic stimulation beat and the head target stimulating point is perpendicular to the magnetic stimulation beat, that is, the relationship between the target stimulating point and the magnetic stimulation beat focusing point is kept in the ideal state, the target stimulating point can be effectively stimulated, and the effectiveness of the magnetic stimulation beat diagnosis and treatment is ensured.
The invention transmits the near-infrared detection signal of the magnetic stimulation beat through the optical fiber, has stable and reliable signal transmission, ensures the accuracy of the absolute value of the blood oxygen concentration obtained by the processing equipment end, and further ensures the positioning correction precision of the magnetic stimulation beat.
Although embodiments of the present invention have been shown and described, it will be appreciated by those skilled in the art that various changes, modifications, substitutions and alterations can be made in these embodiments without departing from the principles and spirit of the invention, the scope of which is defined in the appended claims and their equivalents.
Claims (6)
1. A method for correcting the positioning of an optical fiber during magnetic stimulation imaging, the method comprising:
constructing 4 leads for near infrared detection by using four sections of optical fibers arranged on the magnetic stimulation beat;
performing near infrared detection on the 4 leads to obtain An absolute value An of blood oxygen concentration corresponding to each lead;
judging whether the absolute value An of the blood oxygen concentration of 4 leads meets a detection basic condition An which is not less than B, wherein n =1,2,3,4, B is the minimum effective value of the local blood oxygen concentration of the near infrared detection;
when the detection basic conditions An is larger than or equal to B and n =1,2,3 and 4 are met, judging whether the absolute value of the blood oxygen concentration of 4 leads meets An = Bn +/-C, wherein Bn is the mean value of An, and C is An allowable error amount;
and when the absolute value of the blood oxygen concentration of the 4 leads does not satisfy An = Bn +/-C, adjusting the position of the magnetic stimulation beat according to the An value.
2. The method for positioning and correcting the optical fiber of the magnetic stimulation beat according to claim 1, wherein four optical fibers are arranged on one surface of the magnetic stimulation beat close to a target stimulation point, the four optical fibers are uniformly arranged around a focusing point of the magnetic stimulation beat, the two optical fibers are used as transmitting optical fibers, the two optical fibers are used as receiving optical fibers, and a line segment between the transmitting optical fibers and the receiving optical fibers is used as 1 guide for near-infrared detection.
3. The method for positioning and correcting the optical fibers of the magnetic stimulation beat, according to claim 2, wherein the four optical fibers are arranged in a square shape around the focusing point of the magnetic stimulation beat, wherein two transmitting optical fibers and two receiving optical fibers are symmetrically arranged at the diagonal vertexes of the square shape, and the distance between the adjacent transmitting optical fibers and the adjacent receiving optical fibers is 30mm.
4. The method of magnetic stimulation beat fiber optic positioning correction according to claim 1, further comprising: when the absolute value of the blood oxygen concentration of the 4 leads does not satisfy An = Bn +/-C, the position of the magnetic stimulation beat is adjusted to the direction of smaller value of An.
5. The method for fiber optic localization correction of magnetic stimulation beats as claimed in claim 1, wherein the magnetic stimulation beat starts a treatment procedure when An absolute value of blood oxygen concentration of 4 leads satisfies An = Bn ± C.
6. The method for fiber optic positioning correction of magnetic stimulation beats as claimed in claim 5, wherein during the treatment process of the magnetic stimulation beat, the absolute value of blood oxygen concentration of 4 leads is continuously detected in real time, and when the obtained absolute value of blood oxygen concentration of 4 leads does not satisfy An = Bn ± C, the position of the magnetic stimulation beat is finely adjusted in a direction in which the value of An is smaller.
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| CN107497051A (en) * | 2017-09-25 | 2017-12-22 | 深圳市神经科学研究院 | A kind of trans-skull magnetic stimulating device and transcranial magnetic stimulation method of near infrared signal control |
| CN207755642U (en) * | 2017-06-20 | 2018-08-24 | 苏州大学附属第一医院 | A kind of transcranial magnetic stimulation bat positioning device |
| CN110392594A (en) * | 2019-05-09 | 2019-10-29 | 武汉资联虹康科技股份有限公司 | It is a kind of to be clapped for functional measurement of human brain TMS coil integrated with treatment |
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| CN104363983B (en) * | 2014-08-06 | 2017-03-01 | 中国科学院自动化研究所 | Cerebration detection method and system |
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| CN207755642U (en) * | 2017-06-20 | 2018-08-24 | 苏州大学附属第一医院 | A kind of transcranial magnetic stimulation bat positioning device |
| CN107497051A (en) * | 2017-09-25 | 2017-12-22 | 深圳市神经科学研究院 | A kind of trans-skull magnetic stimulating device and transcranial magnetic stimulation method of near infrared signal control |
| CN110392594A (en) * | 2019-05-09 | 2019-10-29 | 武汉资联虹康科技股份有限公司 | It is a kind of to be clapped for functional measurement of human brain TMS coil integrated with treatment |
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