CN110123318A - One kind sitting calibration method based on electro-ocular signal monitoring eyeball position - Google Patents
One kind sitting calibration method based on electro-ocular signal monitoring eyeball position Download PDFInfo
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- CN110123318A CN110123318A CN201910311345.1A CN201910311345A CN110123318A CN 110123318 A CN110123318 A CN 110123318A CN 201910311345 A CN201910311345 A CN 201910311345A CN 110123318 A CN110123318 A CN 110123318A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B3/00—Apparatus for testing the eyes; Instruments for examining the eyes
- A61B3/10—Objective types, i.e. instruments for examining the eyes independent of the patients' perceptions or reactions
- A61B3/113—Objective types, i.e. instruments for examining the eyes independent of the patients' perceptions or reactions for determining or recording eye movement
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/24—Detecting, measuring or recording bioelectric or biomagnetic signals of the body or parts thereof
- A61B5/316—Modalities, i.e. specific diagnostic methods
- A61B5/398—Electrooculography [EOG], e.g. detecting nystagmus; Electroretinography [ERG]
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/72—Signal processing specially adapted for physiological signals or for diagnostic purposes
- A61B5/7203—Signal processing specially adapted for physiological signals or for diagnostic purposes for noise prevention, reduction or removal
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N5/00—Radiation therapy
Abstract
The present invention relates to one kind to sit calibration method based on electro-ocular signal monitoring eyeball position, this method analyzes electro-ocular signal and extracts eye movement signal, the state of eyeball is judged by analyzing eye movement signal, and then determine eyeball position coordinate, after calculating eyeball position coordinate, it is compared according to eyeball real-time status and radioactivity level distribution situation, provides impaired vision feedback.This method does not need directly to install equipment on eyeball, but the outer circumference in eyes is placed with electrode.By further studying a current potential and oculomotor relationship, corresponding feature is extracted, so as to judge the angle and direction of Rotation of eyeball well using eye current potential EOG, eyeball is accurately positioned.Eyeball position is detected when can be widely used in eye radiotherapy in medical treatment, radiotherapy field photography is prevented and closes on or even involve visual organ official rank critical function organ.
Description
Technical field
The present invention relates to electro-ocular signal processing and analyses, and in particular to one kind monitors eyeball position coordinate based on electro-ocular signal
Method.
Background technique
With the development of modern science and technology, the ocular movement recording methods that can accurately objectively respond eye movement situation constantly gush
It is existing, and the products such as eye tracker, electroculogram instrument are had devised, have the primary condition of medically clinical application.At present in eye
In the clinic diagnosis such as section's disease examination, diagnosis, treatment, ocular movement recording methods have carried out application.
By Intensity-modulated Radiotherapy for Nasopharyngeal Carcinoma (IMRT) clinical practice of many years, domestic and foreign literature reports display IMRT skill
Art can not only significantly improve the curative effect of Nasopharyngeal Carcinoma Patients, and part can be protected to jeopardize the function of organ, be effectively improved patient
Quality of life after radiotherapy.But in the practical Patients During Radiotherapy of patient, in fact it could happen that radiotherapy field photography closes on or even involve view
Feel the critical functions organs such as organ, leads to radioactivity impaired vision.
Radioactivity impaired vision is often irreversible, and therapeutic effect is not good enough, thus active prevention, in time discovery, control in time
Treatment seems most important.For radiotherapy region close to or involved the patients of the organs of vision, in the process of radiotherapy
In, may due to eyeball nonautonomy or unconsciously rotate so that the crystalline lens worst for roentgen dose X tolerance and
Cornea is moved to the beta ray therapy region of high dose by originally safer low dosage region, to cause unnecessary radiation
Property damage.And with current Treatment monitoring equipment, it can not also accomplish real-time eye movement monitoring, find crystalline lens and angle in time
Film is accidentally in high dose region and does not also know where to begin, and needs to design a kind of method that eyeball position can be judged in radiotherapy.
Summary of the invention
In order to solve the problems in the existing technology, the present invention provides a kind of based on electro-ocular signal monitoring eyeball position seat
Calibration method can be efficiently applied in radiotherapy in real time detect eye movement, eyeball can be effectively prevent because non-autonomous
Property or unintentional motion and the generation for leading to radioactivity impaired vision.
Technical proposal that the invention solves the above-mentioned problems is as follows: a kind of side based on electro-ocular signal monitoring eyeball position coordinate
Method, comprising the following steps:
S1, initial electro-ocular signal is pre-processed, removes electro-ocular signal artefact；
S2, eye movement signal is extracted, sets energy threshold, judges whether eye movement starts；
S3, according to extracted eye movement signal, identify eye movement direction；
S4, a relationship for current potential peak value and target point deviation angle is found from the statistical significance, in conjunction with eye movement direction
Determine eyeball position coordinate；
S5, after calculating eyeball position coordinate, carried out pair according to eyeball real-time status and radioactivity level distribution situation
Than providing impaired vision feedback: if crystalline lens and cornea that roentgen dose X tolerance is worst, by originally safer cold spot area
Domain is moved to the beta ray therapy region of high dose, then gives a warning prompt, stops radiotherapy, guidance Rotation of eyeball to safety immediately
Region.
In a preferred embodiment, step S4 carries out preliminary experiment to each individual, and determines eye according to spike potential
Ball body position:
Horizontal EOG value when eyeball maximum deflection amplitude is acquired in the horizontal direction；According to eye electricity EOG spike potential mean value
The good linear relationship that U and eyeball deflection angle have obtains present level EOG value currently partially divided by horizontal EOG maximum value
Ratio r 1 multiplied by horizontal direction maximum deflection amplitude is present level direction by the ratio r 1 for turning amplitude Yu maximum deflection amplitude
On deflection amplitude；
Vertical EOG value when eyeball maximum deflection amplitude is acquired in vertical direction；According to eye electricity EOG spike potential mean value
The good linear relationship that U and eyeball deflection angle have obtains current vertical EOG value currently partially divided by vertical EOG maximum value
Ratio r 2 multiplied by vertical direction maximum deflection amplitude is current vertical direction by the ratio r 2 for turning amplitude Yu maximum deflection amplitude
On deflection amplitude；
According to current eyeball in the horizontal direction on the deflection direction and present level direction in vertical direction and work as
Deflection amplitude in preceding vertical direction determines the specific coordinate of current eyeball.
Compared with prior art, the beneficial effect that the present invention obtains includes:
Eye movement signal is analyzed electro-ocular signal and extracted to this method, and the state of eyeball is judged by analyzing eye movement signal, into
And determine eyeball position coordinate；It does not need that equipment is directly installed on eyeball, but the outer circumference in eyes is placed with electrode.This
Method extracts corresponding feature by further research eye current potential and oculomotor relationship, so as to utilize eye current potential
EOG judges the angle and direction of Rotation of eyeball well, is accurately positioned to eyeball, can be widely used in eye in medical treatment
Eyeball position is detected when radiotherapy, eyeball can be effectively prevent to lead to radioactivity impaired vision because of nonautonomy or unintentional motion
Occur.
Detailed description of the invention
Fig. 1 is that the present invention obtains eye movement situation flow chart；
Fig. 2 is the flow chart of electro-ocular signal removal artefact；
Fig. 3 is the flow chart extracted with eye movement correlated characteristic；
Fig. 4 is the flow chart for identifying eye movement direction；
Fig. 5 is the specific flow chart of the embodiment of the present invention.
Specific embodiment
The present invention is described in detail for following embodiment, but embodiments of the present invention are not limited to this embodiment.
As shown in Figure 1, the present invention is based on electro-ocular signal monitoring eyeball positions to sit calibration method, the same of eye radiotherapy is being carried out
When acquire electro-ocular signal, analyzed on the basis of collecting electro-ocular signal, key step includes that removal electro-ocular signal is pseudo-
Mark extracts eye movement signal, differentiates eye movement direction and calculates the specific coordinate of eyeball position.Carrying out the same of eye radiotherapy
When detect eye movement in real time, stop radiotherapy immediately when detecting that the organs of vision are accidentally in high dose region, protection is tested
The organs of vision of person.
S1, initial electro-ocular signal is pre-processed, removes electro-ocular signal artefact.
Electro-ocular signal removes the process of artefact as shown in Fig. 2, since the electro-ocular signal measured is vulnerable to interference, practical eye telecommunications
Number between 0.05Hz~100Hz, it is therefore desirable to which removing can bring the frequency of baseline drift lower than 0.05Hz's in electro-ocular signal
It is greater than the signal component of 100Hz caused by signal component and interference.
In the present embodiment, the signal component of 0.05Hz is less than by the fertile hereby high-pass filter removal of Bart, reaches elimination
The effect of baseline drift.It is greater than the signal component of 100Hz by wavelet transformation or Butterworth lowpass filters removal.
S2, eye movement signal is extracted, that is, extracts and eye movement correlated characteristic: framing after electro-ocular signal first-order difference is counted again
Short-time energy is calculated, short-time energy threshold value is set, judges whether eye movement starts.
The process with eye movement correlated characteristic is extracted as shown in figure 3, carrying out a scale to pretreated electro-ocular signal s
Partite transport is calculated, and yx (i)=s (i+1)-s (i) is obtained；Framing is carried out to first-order difference signal yx, points can be according to true in actual frame
Truth condition is adjusted, and is carried out a square summation to the data of every frame, is obtained the short-time energy En of the frame, carry out to short-time energy En
Median filtering obtains new sequence Enn.
An Ennn sequence is created, the short-time energy Enn after median filtering is judged, identification short-time energy Enn is
Ennn sequence is set 1, otherwise by Ennn sequence if Enn is greater than the energy threshold set by the no energy threshold for being greater than setting
Set 0.Ennn sequence progress first-order difference is obtained into F sequence, when F sequence is equal to 1, then eye movement just starts in the frame, when F sequence
When column are equal to -1, eye movement is in the frame.How much the size of energy threshold can be adjusted according to counting in a frame.
S3, identification eye movement direction
Fig. 4 is to identify that the flow chart in Rotation of eyeball direction calculates separately it to the eye movement signal that step S2 is extracted
Corresponding first-order difference yx is greater than the 0 points i and points j less than 0, and obtains ratio judge=i/ (i+j).Comparative example
Judge and the upper and lower limit threshold values of setting are compared, and when ratio judge is greater than upper limit threshold, are judged as in the horizontal direction
Eyeball, which turns to, measures horizontal eye electricity positive electrode direction, is judged as that eyeball turns to measurement vertical eye electricity positive electrode side in vertical direction
To；When judge is less than lower threshold, it is judged as that eyeball turns to the electricity negative electricity extreme direction of measurement level eye in the horizontal direction,
It is judged as that eyeball turns in vertical direction and measures vertical eye electricity negative electricity extreme direction；When ratio judge is between lower threshold and the upper limit
When between threshold value, it is judged as blink state.
Actual upper and lower limit threshold value can be adjusted according to truth, and it is 0.7 that the present embodiment, which chooses upper limit threshold, under
Limiting threshold value is 0.3.To measure horizontal eye electricity positive electrode in eyes left, for measuring vertical eye electricity positive electrode above the eyes,
As judge > 0.7, it is judged as eyeball in the horizontal direction to the left, is judged as that eyeball is upward in vertical direction；When judge <
When 0.3, it is judged as eyeball in the horizontal direction to the right, is judged as that eyeball is downward in vertical direction；When 0.3 < judje < 0.7
When, it is judged as blink transition.
S4, eyeball position coordinate is calculated
Since electro-ocular signal has good linear relationship by EOG spike potential mean value U and target point deflection angle θ,
The relationship that a current potential peak value and target point deviation angle θ can be found from the statistical significance determines eyeball in conjunction with eye movement direction
Position coordinates.Preliminary experiment is carried out to each individual, and eyeball specific location is determined according to spike potential:
Preliminary experiment is carried out to each individual, acquires horizontal EOG value when eyeball maximum deflection amplitude in the horizontal direction.Root
According to the good linear relationship that eye electricity EOG spike potential mean value U and eyeball deflection angle have, by present level EOG value divided by water
Flat EOG maximum value obtains the ratio r 1 of current deflection amplitude Yu maximum deflection amplitude, and ratio r 1 is maximum partially multiplied by horizontal direction
The amplitude of turning is the deflection amplitude on present level direction.
Preliminary experiment is carried out to each individual, acquires vertical EOG value when eyeball maximum deflection amplitude in vertical direction.Root
According to the good linear relationship that eye electricity EOG spike potential mean value U and eyeball deflection angle have, by current vertical EOG value divided by vertical
Straight EOG maximum value obtains the ratio r 2 of current deflection amplitude Yu maximum deflection amplitude, and ratio r 2 is maximum partially multiplied by vertical direction
The amplitude of turning is the deflection amplitude on current vertical direction.
According to current eyeball in the horizontal direction on the deflection direction and present level direction in vertical direction and work as
Deflection amplitude in preceding vertical direction determines the specific coordinate of current eyeball.
S5, impaired vision feedback is provided
After calculating eyeball position coordinate, compared according to eyeball real-time status and radioactivity level distribution situation,
Provide impaired vision feedback: if crystalline lens and cornea that roentgen dose X tolerance is worst, by originally safer low dosage region,
It is moved to the beta ray therapy region of high dose, then gives a warning prompt, stops radiotherapy, voice guide Rotation of eyeball to safety immediately
Region, avoid the occurrence of impaired vision symptom.Remaining situation will be prompted not, keep the monitor state of a safety.
To measure horizontal eye electricity positive electrode in eyes left, for measuring vertical eye electricity positive electrode above the eyes.This reality
Applying and taking in first-order difference yx in example at 2 points is a frame, the every frame energy threshold value 40 of short-time energy, upper limit threshold setting 0.7, lower limit
Threshold value setting 0.3, is illustrated in figure 5 the flow chart for calculating eyeball position coordinate.
Pretreatment removal eye electricity artefact is carried out to collected electro-ocular signal, is removed by the fertile hereby high-pass filter of Bart small
In the signal component of 0.05Hz, achieve the effect that eliminate baseline drift.It is gone by wavelet transformation or Butterworth lowpass filters
Except the signal component for being greater than 100Hz.
Its first-order difference yx is asked to pretreated electro-ocular signal, framing is carried out to first-order difference yx, with 2 points for a frame,
A square summation is carried out to the data of every frame, obtains short-time energy En.Median filtering is carried out to short-time energy signal En, obtains new sequence
Arrange Enn.Short-time energy Enn after median filtering is judged, sets energy threshold as 40.Newly-built sequence F a, if frame is in short-term
Energy is greater than 40, then new sequence F value sets 1, which is in eye movement state；If a frame short-time energy, less than 40, new sequence F value is set
0, which is not at eye movement state.
To every section of eye movement signal, the points i and points j less than 0 that its corresponding first-order difference yx is greater than 0 is calculated, and obtain
To ratio judge=i/ (i+j), as judge > 0.7, it is judged as that eyeball turns to measurement level eye electricity positive electricity in the horizontal direction
Extreme direction is judged as that eyeball turns in vertical direction and measures vertical eye electricity positive electrode direction；As judge < 0.3, in level
It is judged as that eyeball turns to the electricity negative electricity extreme direction of measurement level eye on direction, it is vertical is judged as that eyeball turns to measurement in vertical direction
The electric negative electricity extreme direction of eye；As 0.3 < judje < 0.7, it is judged as blink transition.
Preliminary experiment is carried out to each individual, acquires horizontal EOG value when eyeball maximum deflection amplitude in the horizontal direction.Root
There is good linear relationship according to eye electricity EOG spike potential mean value U and eyeball deflection angle, by present level EOG value divided by water
Flat EOG maximum value obtains the ratio r 1 of current deflection amplitude Yu maximum deflection amplitude, and ratio r 1 is maximum partially multiplied by horizontal direction
The amplitude of turning is the deflection amplitude on present level direction.
Preliminary experiment is carried out to each individual, acquires vertical EOG value when eyeball maximum deflection amplitude in vertical direction.Root
There is good linear relationship according to eye electricity EOG spike potential mean value U and eyeball deflection angle, by current vertical EOG value divided by vertical
Straight EOG maximum value obtains the ratio r 2 of current deflection amplitude Yu maximum deflection amplitude, and ratio r 2 is maximum partially multiplied by vertical direction
The amplitude of turning is the deflection amplitude on current vertical direction.
According to deflection direction and the present level deflected in direction and vertical direction of current eyeball in the horizontal direction
The deflection amplitude on deflection amplitude and current vertical direction on direction, determines the specific coordinate of current eyeball.If detecting view
Feel and stop radiotherapy when organ is accidentally in high dose region immediately, protects the organs of vision.
Specific embodiments of the present invention are described above.It is to be appreciated that the invention is not limited to above-mentioned
Particular implementation, it may occur to persons skilled in the art that various deformations or amendments, but in the premise for not departing from disclosure spirit
Under, all modifications and replacement made are fallen in the disclosure protection scope that appended claims define.
Claims (7)
1. one kind sits calibration method based on electro-ocular signal monitoring eyeball position, which comprises the following steps:
S1, initial electro-ocular signal is pre-processed, removes electro-ocular signal artefact；
S2, eye movement signal is extracted, sets energy threshold, judges whether eye movement starts；
S3, according to extracted eye movement signal, identify eye movement direction；
S4, a relationship for current potential peak value and target point deviation angle is found from the statistical significance, determine in conjunction with eye movement direction
Eyeball position coordinate；
S5, after calculating eyeball position coordinate, compared, given according to eyeball real-time status and radioactivity level distribution situation
Impaired vision is fed back out: if crystalline lens and cornea that roentgen dose X tolerance is worst, by originally safer low dosage region, being moved
The beta ray therapy region for moving high dose, then give a warning prompt, stops radiotherapy, guidance Rotation of eyeball to the area of safety immediately
Domain.
2. the method according to claim 1, wherein in step S2, to pretreated one scale of electro-ocular signal
Framing calculates short-time energy again after point, sets short-time energy threshold value, judges whether eye movement starts.
3. according to the method described in claim 2, it is characterized in that, carrying out first-order difference fortune to pretreated electro-ocular signal s
It calculates, obtains yx (i)=s (i+1)-s (i)；Framing is carried out to first-order difference signal yx, a square summation is carried out to the data of every frame,
The short-time energy En of the frame is obtained, median filtering is carried out to short-time energy En and obtains new sequence Enn；
An Ennn sequence is created, the short-time energy Enn after median filtering is judged, whether identification short-time energy Enn is big
Ennn sequence is set 1, Ennn sequence is otherwise set 0 if Enn is greater than the energy threshold set in the energy threshold of setting；
Ennn sequence progress first-order difference is obtained into F sequence, when F sequence is equal to 1, then eye movement just starts in the frame, when F sequence etc.
When -1, eye movement is in the frame.
4. according to the method described in claim 2, it is characterized in that, calculating separately it to the extracted eye movement signal of step S2
Corresponding first-order difference is greater than the 0 points i and points j less than 0, and obtains ratio judge=i/ (i+j)；Comparative example judge
It is compared with the upper and lower limit threshold values of setting, when ratio judge is greater than upper limit threshold, is judged as eyeball in the horizontal direction
It turns to and measures horizontal eye electricity positive electrode direction, be judged as that eyeball turns in vertical direction and measure vertical eye electricity positive electrode direction；
When ratio judge is less than lower threshold, it is judged as that eyeball turns to the electricity negative electricity extreme direction of measurement level eye in the horizontal direction,
It is judged as that eyeball turns in vertical direction and measures vertical eye electricity negative electricity extreme direction；When ratio judge is between lower threshold and the upper limit
When between threshold value, it is judged as blink state.
5. the method according to claim 1, wherein step S4 carries out preliminary experiment to each individual, and according to peak
Value current potential determines eyeball specific location:
Horizontal EOG value when eyeball maximum deflection amplitude is acquired in the horizontal direction；According to eye electricity EOG spike potential mean value U with
The good linear relationship that eyeball deflection angle has obtains present level EOG value divided by horizontal EOG maximum value currently to deflect width
Ratio r 1 multiplied by horizontal direction maximum deflection amplitude is on present level direction by degree and the ratio r 1 of maximum deflection amplitude
Deflection amplitude；
Vertical EOG value when eyeball maximum deflection amplitude is acquired in vertical direction；According to eye electricity EOG spike potential mean value U with
The good linear relationship that eyeball deflection angle has obtains current vertical EOG value divided by vertical EOG maximum value currently to deflect width
Ratio r 2 multiplied by vertical direction maximum deflection amplitude is on current vertical direction by degree and the ratio r 2 of maximum deflection amplitude
Deflection amplitude；
It is hung down in the horizontal direction on the deflection direction and present level direction in vertical direction with current according to current eyeball
The upward deflection amplitude of histogram determines the specific coordinate of current eyeball.
6. the method according to claim 1, wherein the pretreatment of step S1 includes: meeting in removal electro-ocular signal
Signal component caused by bringing the signal component of baseline drift and interfering.
7. according to the method described in claim 6, it is characterized in that, being removed in electro-ocular signal by the fertile hereby high-pass filter of Bart
The signal component that baseline drift can be brought is removed to interfere in electro-ocular signal and be led by wavelet transformation or Butterworth lowpass filters
The signal component of cause.
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| CN113995526A (en) * | 2021-11-30 | 2022-02-01 | 华中科技大学 | System for determining treatment area of vision correction surgery |
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| CN110123318B (en) | 2021-03-30 |
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