CN107550451B - Method and system for natural and objective assessment of visual field function - Google Patents
Method and system for natural and objective assessment of visual field function Download PDFInfo
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Abstract
The invention provides a system for natural and objective assessment of visual field function, which comprises: the system comprises a host control unit, a display unit and a human-computer interaction unit; the host control unit comprises a calculation module, a judgment module, an adjustment module and a storage module, and the human-computer interaction unit comprises a receiving module and a feedback module. The system for naturally and objectively evaluating the visual field function provides a system for naturally and objectively evaluating the visual field function for a subject by changing a visual masking technology in basic research of visual psychophysics so as to quantitatively evaluate the functional level of the visual field, and can be widely popularized to clinical diagnosis of neuroophthalmology.
Description
Technical Field
The invention relates to a visual field function evaluation system, in particular to a visual field function natural objective evaluation system.
Background
The visual field refers to a space range in which a target can be found when the examined eye (single eye or double eyes) is fixed, and is one of the most important visual functions of human beings; the visual field defect is a very serious visual lesion, brings great harm to human health, and brings great loss to social economy.
The traditional visual field examination uses the average light sensitivity of retina as an index, and is mainly used for realizing early recognition and diagnosis of routine ophthalmic diseases such as glaucoma, macular degeneration and the like. The existing perimeter meters are mainly classified into two types, one is a dynamic perimeter meter (kinetic perimeter), which projects a light spot into the interior of a semi-arc ball, and gradually presents the light spot from the outer periphery to the center of the visual field until the subject can see the light spot. Another is a static perimeter (static perimeter) which works by fixing a spot at a certain position and then gradually changing the intensity of the scintillation spot until it can be seen by the subject.
In operation, the conventional perimeter presents visual stimuli (generally light spots) at different visual field positions, so that a subject can judge whether the presented light spots are seen, and the subjectivity is high. Especially for already impaired fields of vision, a subjective response is still required, which may misestimate the effective field of vision of the subject. For severely impaired fields, subjects often subjectively report no stimulus, but still require subjects to report whether a stimulus is present in the impaired field, which is clearly not a natural measure.
Disclosure of Invention
Therefore, based on the shortcomings of the prior art, it is an object of the present invention to provide a system for natural objective assessment of visual field function.
In order to achieve the above object, the present invention provides a system for natural objective assessment of visual field function, wherein the system comprises: the system comprises a host control unit, a display unit and a human-computer interaction unit; the host control unit comprises a calculation module, a judgment module, an adjustment module and a storage module, and the human-computer interaction unit comprises a receiving module and a feedback module;
the calculation module determines parameters of the sighting target according to the cutoff spatial frequency of the subject, the display unit displays the central fixation point and the sighting target of the parameters determined by the calculation module or the sighting target of the parameters adjusted by the adjustment module to the subject, and the receiving module receives and records corresponding operations made by the subject according to the sighting target; the feedback module feeds back the operation record of the subject to the host control unit, the judging module judges whether the operation record is correct according to the parameters of the sighting target, the adjusting module adjusts the parameters of the sighting target during the next test according to the judging result of the judging module, and the storage module stores the parameters of the sighting target, the operation record and/or the judging result;
preferably: the optotypes are respectively a sample stimulation optotype (sample stimulus), a mask stimulation optotype (mask stimulus) and a test stimulation optotype (test stimulus) according to a display sequence, the optotypes are sinusoidal gratings, points, faces, numbers, pictures, figures, natural stimuli and/or Gabor stimuli, and/or the cut-off spatial frequency (cut-off spatial frequency) is determined according to a contrast sensitivity function (contrast sensitivity function) of a subject, and more preferably, when the contrast is 0.99, the spatial frequency corresponding to the contrast sensitivity function is selected as the cut-off spatial frequency.
Where the measurement field of view may be determined from a conventional perimeter, or from the subject judging the simple presentation of 4 graphs in a given four quadrant.
According to the system for natural and objective assessment of visual field function provided by the invention, the condition that the display unit displays the visual field position of the sighting target comprises the following conditions:
the sample stimulation visual target, the masking stimulation visual target and the test stimulation visual target are all displayed in the ipsilateral visual field of the testee, namely, are displayed on the same side; or
The sample stimulation and test stimulation targets are displayed in the ipsilateral visual field of the subject and the mask stimulation target is displayed in the opposite side visual field of the subject, i.e. presented contralaterally, preferably the sample stimulation and test stimulation targets are in the same position. Wherein the visual field may be a right side visual field, a left side visual field, an intact visual field, or an injured visual field of the subject.
In some embodiments, the ipsilateral presentation can be such that the sample stimulating, masking stimulating, and testing stimulating optotypes are all displayed in the left or right visual field of the subject; the contralateral presentation may display the sample stimulation and test stimulation targets in the left field of the subject and the mask stimulation targets in the right field of the subject, or the contralateral presentation may display the sample stimulation and test stimulation targets in the right field of the subject and the mask stimulation targets in the left field of the subject. In other embodiments, the ipsilateral presentation can be such that the sample stimulating, mask stimulating, and test stimulating optotypes are all displayed in the subject's intact visual field; the contralateral presentation may display the sample stimulus visual target and the test stimulus visual target in an intact visual field of the subject and the mask stimulus visual target in an impaired visual field of the subject, or the contralateral presentation may display the sample stimulus visual target and the test stimulus visual target in an impaired visual field of the subject and the mask stimulus visual target in an intact visual field of the subject.
According to the system for natural and objective assessment of visual field function provided by the invention, the visual target parameters determined by the computing unit or adjusted by the adjusting unit are selected from one or more of the following parameters: the visual target comprises the spatial frequency of the visual targets, the physical strength of the visual targets, the contrast of the visual targets, the shapes of the visual targets, the colors of the visual targets, the number of the visual targets, the orientation of the visual targets, the motion direction of the visual targets, the graphs of the visual targets, the positions of the visual targets, the visual field positions of the visual targets, the display duration of the visual targets and the time interval between every two visual target displays. The display time of the sighting target can be 380 milliseconds, and the time interval between every two sighting targets can be 1500 milliseconds.
According to the system for natural and objective assessment of visual field function provided by the invention, when the determination result of the determination module is correct for three times continuously, the adjustment module adjusts the parameters of the visual target in the next test, and when the determination result of the determination module is wrong, the adjustment module adjusts the parameters of the visual target in the next test; the parameter is preferably the absolute difference in spatial frequency between the sample stimulus visual target and the test stimulus visual target.
In one embodiment, when the determination result of the determination module is correct for three consecutive times, the absolute difference of the spatial frequency between the sample stimulation visual target and the test stimulation visual target displayed by the display unit is reduced relative to the absolute difference of the previous test (i.e. test); when the judgment result of the judgment module is wrong, the absolute difference of the spatial frequency between the sample stimulation visual target and the test stimulation visual target displayed by the display unit is increased relative to the absolute difference of the previous test.
Specifically, the absolute difference of the spatial frequency between the sample stimulation visual target and the test stimulation visual target can be determined according to a 3-1-step method (3-down-1-up stationary method) in the psychophysics, that is, when a subject correctly judges the sequence of the visual targets with higher spatial frequency in the sample stimulation visual target and the masking stimulation visual target for three times continuously, the absolute difference of the spatial frequency between the sample stimulation visual target and the test stimulation visual target of the next test time is reduced by 10% relative to the absolute difference of the spatial frequency of the test time; when the examinee judges the sequence of the sample stimulation optotypes and the optotypes with higher spatial frequencies in the test stimulation optotypes by mistake at any time, the absolute difference of the spatial frequencies between the sample stimulation optotypes and the test stimulation optotypes of the next test time is increased by 10 percent relative to the absolute difference of the spatial frequencies of the test time.
According to the system for natural and objective assessment of visual field function provided by the invention, the receiving module receives and records judgment made by a subject according to the parameters of the sample stimulation visual target and/or the test visual target.
According to the system for natural and objective assessment of visual field function provided by the invention, the receiving module receives and records the operation of a subject for judging the sequence of appearance of the visual target with higher spatial frequency in the sample stimulation visual target and the test stimulation visual target.
According to the system for natural and objective assessment of visual field function provided by the invention, the host control unit further comprises an assessment module, the assessment module assesses the visual field function of the subject according to the parameters of the sighting target, the operation records and/or the judgment result stored by the storage module, and preferably, the visual field function is selected from one or more of the following: contrast sensitivity, spatial frequency discrimination threshold, and impaired field of view range.
The system for natural and objective assessment of visual field function provided by the invention is characterized in that the assessment is carried out by determining the spatial frequency discrimination threshold of the subject under the spatial frequency ratio (MSR) of different masking stimulus visual targets and sample stimulus visual targets. Preferably, the spatial frequency ratio of the masking stimulation visual target to the sample stimulation visual target is 0-2.
The system for natural objective assessment of visual field function provided by the invention is characterized in that the discrimination threshold of the subject is as follows: when the sample and test stimulus targets are displayed in the ipsilateral visual field of the subject and the mask stimulus targets are displayed in the opposite lateral visual field of the subject, the subject has a threshold limit for discrimination of the absolute difference in spatial frequency between the test stimulus targets and the sample stimulus targets.
According to the system for naturally and objectively evaluating the visual field function, provided by the invention, the host control unit is an intelligent device, preferably a computer, a smart phone, a tablet computer, a wearable device and/or a PDA intelligent terminal; the display unit is a display device, preferably a cathode ray tube display, a liquid crystal display, a light emitting diode display or an organic light emitting diode display; and/or the human-computer interaction unit is a wireless keyboard, a wired keyboard, a mouse, a touch pad, an operating rod, a handle and/or a track ball.
The present invention utilizes the effect of presenting a visual masking stimulus in the impaired field on the completion of a specific visual task in the intact field (as compared to a sample stimulus and a test stimulus both presented in the intact field) to assess the function of the impaired field; visual function attributes (such as contrast sensitivity, spatial resolution threshold, etc.) of the impaired field of view can be determined by adjusting attributes such as contrast and spatial frequency of the masking stimulus; the function of the impaired field may also be traversed by changing the location of the masking stimulus in the impaired field. The selected stimulus can be Gabor stimulus, face, number, natural stimulus, picture, point, other graph and other stimuli, and the task can also be other tasks with the cross-visual field masking effect, such as random point motion, face emotion recognition, motion direction recognition, frequency recognition, color recognition, size recognition and the like.
Aiming at the problem that the existing perimeter can not provide natural objective assessment for the damaged visual field, the invention provides a system for natural objective assessment of visual field function for a subject by changing visual masking technology in basic research of visual psychophysics so as to quantitatively assess the residual function level of the damaged visual field, and can be widely popularized to the neuro-ophthalmic clinical diagnosis.
Specifically, the system for natural and objective assessment of visual field function provided by the present invention is shown in fig. 1, and comprises: the system comprises a host control unit, a display unit and a human-computer interaction unit. Wherein, according to a traditional perimeter, or according to the condition that the patient judges the simply presented 4 figures in the given four quadrants, the quadrant in which the visual pattern is presented is determined; the control unit is used for determining individualized measurement sighting target parameters which are most suitable for the testee according to the quantitative analysis result of the personal visual function damage characteristics of the testee; and the display unit is used for presenting the visual graphics (namely the sighting target graphics) on the display unit. The man-machine interaction unit records the data of the testee, feeds the result back to the control unit and sets the parameters of the visual target to be presented next time.
The working flow of the system for naturally and objectively evaluating the visual field function provided by the invention is shown in fig. 2, a sinusoidal grating is used as a test visual target graph, and three visual target graphs are respectively presented in sequence in the test process. The visual target pattern presented for the first time is called sample stimulus, the visual target pattern presented for the second time is called masking stimulus, and the visual target pattern presented for the third time is called test stimulus. Each sighting target graph is presented for 380 milliseconds, and the time interval between every two sighting target graphs is 1500 milliseconds. Prior to visual field testing, the contrast sensitivity function of the subject may be measured to determine the cut-off spatial frequency of the subject, from which the spatial frequencies of the sample stimulus, test stimulus and masking stimulus are selected, and ultimately the masking stimulus-sample stimulus spatial frequency ratio (i.e., the spatial frequency ratio of the masking stimulus visual target and the sample stimulus visual target, which may be denoted as MSR) is determined. After determining the visual field to be measured, the visual field function evaluation is started formally. In the test process, the control unit calculates and controls the visual target graph and the presenting time thereof, and the display unit displays the visual target graph presented at different time points. When the display unit presents the visual target graph, the sample stimulus and the test stimulus are presented in the same visual field position in a matching mode, and the masking stimulus can appear in different visual field positions. The sample stimulus and the test stimulus are presented in the intact field, while the masking stimulus is presented in the damaged field. In the test process, a subject needs to keep staring at the central fixation point of the display unit with both eyes, simultaneously needs to remember the difference of the sample stimulus and the test stimulus on the spatial frequency, and then judges the appearance sequence of the visual target graph with higher spatial frequency in the sample stimulus and the test stimulus in the man-machine interaction unit. The control system judges whether the judgment obtained from the human-computer interaction system is correct or not, timely adjusts the respective spatial frequency of the sample stimulation, the masking stimulation and/or the test stimulation in the next test on line, records and stores the parameters of the visual target stimulation and the reaction obtained in the human-computer interaction of the testee, and then displays a new visual target graph required by the test on the display unit.
The test example of the system for natural and objective assessment of visual field function provided by the invention is shown in fig. 3, wherein the mark 1 in fig. 3 shows that all visual target graphs are presented in the center of the visual field, and a subject needs to see the visual graphs with both eyes and make a judgment; FIG. 3, item 2, shows that both the sample stimulus and the test stimulus are presented on the same side of the field of view, where the field of view is the subject's intact field of view; fig. 3, item 3, shows that the sample stimulus and the test stimulus are present in the intact visual field, while the masking stimulus is present in the impaired visual field. By comparing the results presented ipsilaterally and contralaterally under different stimulus attributes (contrast, spatial frequency and presentation position), the level of residual function of the impaired visual field of the subject can be effectively assessed.
Aiming at the problem that objective evaluation cannot be provided in the traditional perimeter, the suppression coefficient of the masking stimulus to the test stimulus is determined by systematically adjusting the difference between the spatial frequency of the test stimulus and the spatial frequency of the masking stimulus, and finally, the spatial frequency discrimination threshold of the test stimulus is estimated under the suppression condition of the masking stimulus, so that the condition of residual visual function in the damaged visual field is estimated, the degree of the masking stimulus for suppressing the test stimulus is not controlled by the subjectivity of a subject, and the method is an objective psychophysics testing method and can avoid the problem of inaccurate estimation caused by subjective report.
Aiming at the problem that a subject still needs to react to an invisible light spot in the traditional perimeter test, the designed measurement method provided by the invention is that the subject judges a visible test grating without reacting to a masking stimulus, and only needs to watch the masking stimulus. This ensures that the subject naturally responds to the visible stimulus throughout the examination.
Drawings
Embodiments of the invention are described in detail below with reference to the attached drawing figures, wherein:
FIG. 1 shows the structure of a system for natural objective assessment of the visual field function;
FIG. 2 illustrates the workflow of the system for natural objective assessment of the visual field function;
FIG. 3 illustrates the visual target graph example and a single test flow instance;
FIG. 4 shows the test results of a system for natural objective assessment of normal human use of the visual field function;
FIG. 5 shows the mean test results of the subject of example 2 using the system for natural objective assessment of visual field function;
FIG. 6 shows the test results of a system for natural objective assessment of visual field function using one subject in example 2.
Description of reference numerals:
1. all the sighting target graphs are presented in the center of the visual field; 2. the sample stimulus and the test stimulus are both presented on the same side of the field of view, wherein the field of view is an intact field of view of the subject; 3. the sample stimulus and the test stimulus are presented in the intact visual field, while the masking stimulus is presented in the impaired visual field.
Detailed Description
The invention is further illustrated by the following specific examples, which, however, are to be construed as merely illustrative, and not limitative of the remainder of the disclosure in any way whatsoever.
As shown in fig. 1, the present invention provides a system for natural objective assessment of visual field function, wherein the system comprises: the system comprises a host control unit, a display unit and a human-computer interaction unit; the host control unit comprises a calculation module, a judgment module, an adjustment module and a storage module, and the human-computer interaction unit comprises a receiving module and a feedback module;
the calculation module determines parameters of the sighting target according to the cutoff spatial frequency of the subject, the display unit displays the central fixation point and the sighting target of the parameters determined by the calculation module or the sighting target of the parameters adjusted by the adjustment module to the subject, and the receiving module receives and records corresponding operations made by the subject according to the sighting target; the feedback module feeds back an operation record to the host control unit, the judging module judges whether the operation record is correct according to the parameters of the sighting target, the adjusting module adjusts the parameters of the sighting target during the next test according to the judging result of the judging module, and the storage module stores the parameters of the sighting target, the operation record and/or the judging result; the sighting marks are respectively a sample stimulation sighting mark (sample stimulus), a masking stimulation sighting mark (mask stimulus) and a test stimulus (test stimulus) according to the display sequence, and the sighting marks are sinusoidal gratings.
The optotype parameters determined by the calculation unit or adjusted by the adjustment unit are selected from one or more of the following parameters: the visual target comprises the spatial frequency of the visual targets, the physical strength of the visual targets, the contrast of the visual targets, the shapes of the visual targets, the colors of the visual targets, the number of the visual targets, the orientation of the visual targets, the motion direction of the visual targets, the graphs of the visual targets, the positions of the visual targets, the visual field positions of the visual targets, the display duration of the visual targets and the time interval between every two visual target displays.
When measuring, the visual field position of the sighting mark comprises two conditions: ipsilateral and contralateral presentations.
The display unit displays the sample stimulation visual target and the test stimulation visual target which are different in spatial frequency and same in presentation position. The receiving module receives and records the operation of the testee for judging the appearance sequence of the visual targets with higher spatial frequency in the sample stimulation visual targets and the test stimulation visual targets.
When the determination result of the determination module is correct for three times continuously, the adjustment module adjusts the parameters of the optotype in the next test, and when the determination result of the determination module is wrong, the adjustment module adjusts the parameters of the optotype in the next test, wherein the parameters of the optotype are the absolute difference of the spatial frequency between the sample stimulation optotype and the test stimulation optotype. In other words, when the determination result of the determination module is correct for three consecutive times, the absolute difference of the spatial frequency between the sample stimulation visual target and the test stimulation visual target displayed by the display unit is reduced relative to the absolute difference of the previous test; when the judgment result of the judgment module is wrong, the absolute difference of the spatial frequency between the sample stimulation visual target and the test stimulation visual target displayed by the display unit is increased relative to the absolute difference of the previous test.
And (4) until the test is finished, namely the test subject judges all preset test times in the computer control system, the test system is quitted, and the display unit presents a brief test result.
For ease of understanding, specific examples are set forth for further illustration.
Example 1
The system for naturally and objectively evaluating the visual field function provided by the invention is used for measuring the visual field function of a normal person.
A sinusoidal grating with a spatial frequency of 10 degrees per week (cpd) was determined as a masking stimulus based on the measurement field and the cutoff spatial frequency of the subject, and discrimination thresholds were measured for the central, left and right fields when MSR ═ 0, 0.5, 0.6, 1, 0.8, 1.0, 1.25, 1.6, or 2, respectively.
The specific measurement process is as follows:
(1) the display unit presents a central fixation point and successively presents a sample stimulation visual target, a masking stimulation visual target and a test stimulation visual target respectively, wherein the presentation time of each visual target is 380 milliseconds, the time interval between every two visual targets is 1500 milliseconds, the presentation positions of the sample stimulation visual target and the test stimulation visual target are the same but the spatial frequencies are different, the masking stimulation is presented on the opposite side, at the moment, a subject needs to stare at the central fixation point by two eyes all the time, and the difference of the spatial frequencies of the sample stimulation visual target and the test stimulation visual target is memorized;
(2) a subject judges the sequence of the appearance of the visual targets with higher spatial frequency in the sample stimulating visual targets and the test stimulating visual targets on the human-computer interaction unit, and the human-computer interaction unit receives, records and judges the sequence and feeds the sequence back to the control unit;
(3) the judging module judges whether the judgment in the step (2) is correct or not;
(4) when the determination result is correct for three times continuously, the adjusting module adjusts the sighting target parameters to enable the sighting target parameters to be presented as a sample stimulation sighting target and a test stimulation sighting target with a spatial frequency difference value reduced by 10% relative to the previous trial time on the display unit when the next test is carried out, and when the determination result is wrong, the adjusting module adjusts the sighting target parameters to enable the sighting target parameters to be presented as a sample stimulation sighting target and a test sighting target with a spatial frequency difference value increased by 10% relative to the previous trial time on the display unit when the next test is carried out, and at the moment, the storage module stores the sighting target parameters and the determination result of the testee;
(5) obtaining a discrimination threshold limit of the test stimulation targets by the test subjects according to the target parameters and the judgment and judgment results of the test subjects, namely judging the sequence of the test stimulation targets appearing by the test subjects in the step (4), wherein the sequence of the test stimulation targets appearing with higher spatial frequency in the sample stimulation targets and the test stimulation targets is correct if the sequence of the test stimulation targets is the same as the sequence preset in the control system, and wrong if the sequence of the test stimulation targets is different from the sequence preset in the control system, and finally calculating that the absolute difference value of the spatial frequency between the sample stimulation targets and the test stimulation targets is the discrimination threshold limit when the correct response rate is 80%, in other words, when the discrimination threshold intensity is reached, the test subjects have a probability of correctly judging the sequence of the test targets appearing with higher spatial frequency in the sample stimulation targets and the test stimulation targets;
(6) the test subject finishes all preset test times in the control system, quits the test system, and presents a brief result diagram of the test at this time on the display unit.
The test results are shown in fig. 4, where the threshold value measured when the MSR is 0, i.e. when no masking stimulus is present, is not different from the threshold value measured when the MSR is 1. When the MSR deviates from 1, the threshold increases with increasing deviation. Normal persons have similar response patterns in both the central and left and right fields, indicating that the effect is stable.
Example 2
The present implementation measures visual field function of a subject using the system for natural objective assessment of visual field function provided by the present invention.
The subjects were 5 subjects with impaired visual field function.
When MSR is 0, 0.5, 0.6, 1, 0.8, 1.0, 1.25, 1.6 or 2, the discrimination threshold is measured for ipsilateral or contralateral presentation, respectively, of the visual target.
The specific measurement process is as follows:
(1) the display unit presents a central fixation point and successively presents a sample stimulation visual target, a masking stimulation visual target and a testing stimulation visual target respectively, the visual targets are presented on the same side or on the opposite side, wherein the presentation time of each visual target is 380 milliseconds, the time interval between every two visual targets is 1500 milliseconds, the presentation positions of the sample stimulation visual target and the testing stimulation visual target are the same but the spatial frequencies are different, at the moment, a subject needs to stare at the central fixation point by two eyes all the time, and the difference of the spatial frequencies of the sample stimulation visual target and the testing stimulation visual target is remembered;
(2) a subject judges the sequence of the appearance of the visual targets with higher spatial frequency in the sample stimulating visual targets and the test stimulating visual targets on the human-computer interaction unit, and the human-computer interaction unit receives, records and judges the sequence and feeds the sequence back to the control unit;
(3) the judging module judges whether the judgment in the step (2) is correct or not;
(4) when the determination result is correct for three times continuously, the adjusting module adjusts the sighting target parameters to enable the sighting target parameters to be presented as a sample stimulation sighting target and a test stimulation sighting target with a spatial frequency difference reduced by 10% relative to the previous trial time on the display unit in the next test, and when the determination result is wrong, the adjusting module adjusts the sighting target parameters to enable the sighting target parameters to be presented as a sample stimulation sighting target and a test sighting target with a spatial frequency difference increased by 10% relative to the previous trial time on the display unit in the next test, and at the moment, the storage module stores the sighting target parameters and the determination result of the testee;
(5) obtaining a discrimination threshold limit of the test stimulation targets by the test subjects according to the target parameters and the judgment and judgment results of the test subjects, namely judging the sequence of the test stimulation targets appearing by the test subjects in the step (4), wherein the sequence of the test stimulation targets appearing with higher spatial frequency in the sample stimulation targets and the test stimulation targets is correct if the sequence of the test stimulation targets is the same as the sequence preset in the control system, and wrong if the sequence of the test stimulation targets is different from the sequence preset in the control system, and finally calculating that the absolute difference value of the spatial frequency between the sample stimulation targets and the test stimulation targets is the discrimination threshold limit when the correct response rate is 80%, in other words, when the discrimination threshold intensity is reached, the test subjects have a probability of correctly judging the sequence of the test targets appearing with higher spatial frequency in the sample stimulation targets and the test stimulation targets;
(6) the test subject finishes all preset test times in the control system, quits the test system, and presents a brief result diagram of the test at this time on the display unit.
The test results are shown in fig. 5 and 6, where fig. 5 is the average of discrimination thresholds measured by 5 subjects, and fig. 6 is the measurement result of one subject. As can be seen from fig. 5 and 6, when both the masking stimulus and the test stimulus were presented to the subjects in the intact visual field, it can be seen that as the MSR gradually deviated from 1, the threshold value was continuously increased, indicating that all the stimuli were effectively treated in the intact visual field, while when the MSR was 0, the measured threshold value was not statistically different from the threshold value obtained when the MSR was 1, and the results obtained by placing all the stimuli in the intact visual field were in a similar pattern to those obtained by normal persons; in the case of placing the sample stimulus and the test stimulus in the intact visual field and the masking stimulus in the impaired visual field, when the MSR is less than 1, the result obtained when the threshold value is significantly higher than MSR 1 is obtained, which indicates that the impaired visual field performs effective processing on the stimuli at the spatial frequency, and when the MSR is gradually higher than 1, the threshold value linearly increases, but the increase amplitude is not very large, which indicates that the impaired visual field still performs a certain degree of processing on the visual stimuli at the intensity; when MSR is 2, the results are not statistically different from MSR 1, indicating that at this spatial frequency, the impaired field is not able to handle visual stimuli.
Although the present invention has been described to a certain extent, it is apparent that appropriate changes in the respective conditions may be made without departing from the spirit and scope of the present invention. It is to be understood that the invention is not limited to the described embodiments, but is to be accorded the scope consistent with the claims, including equivalents of each element described.
Claims (19)
1. A system for natural objective assessment of visual field function, the system comprising: the system comprises a host control unit, a display unit and a human-computer interaction unit; wherein the content of the first and second substances,
the host control unit comprises a calculation module, a judgment module, an adjustment module and a storage module,
the human-computer interaction unit comprises a receiving module and a feedback module;
the calculation module determines parameters of the sighting target according to the cutoff spatial frequency of the subject, the display unit displays the central fixation point and the sighting target of the parameters determined by the calculation module or the sighting target of the parameters adjusted by the adjustment module to the subject, and the receiving module receives and records corresponding operations made by the subject according to the sighting target; the feedback module feeds back an operation record to the host control unit, the judging module judges whether the operation record is correct according to the parameters of the sighting target, the adjusting module adjusts the parameters of the sighting target during the next test according to the judging result of the judging module, and the storage module stores the parameters of the sighting target, the operation record and/or the judging result; wherein the content of the first and second substances,
the visual targets are respectively a sample stimulation visual target, a masking stimulation visual target and a test stimulation visual target according to the display sequence; and/or
The cut-off spatial frequency is determined from a contrast sensitivity function of the subject.
2. The system for natural objective assessment of visual field function according to claim 1, wherein said visual target is a sinusoidal grating, dots, faces, numbers, pictures, figures, natural stimuli.
3. The system for natural objective assessment of visual field function according to claim 1, wherein the cut-off spatial frequency is selected as the spatial frequency corresponding to the contrast sensitivity function when the contrast is 0.99.
4. The system for natural objective assessment of visual field function according to claim 1, wherein said visual target is a Gabor stimulus.
5. The system for natural objective assessment of visual field function according to claim 1, wherein said display unit displaying the visual field position of said optotype includes the following situations:
the sample stimulation visual target, the masking stimulation visual target and the test stimulation visual target are all displayed in the ipsilateral visual field of the subject; or
The sample stimulation and test stimulation optotypes are displayed in ipsilateral visual fields of the subject and the mask stimulation optotypes are displayed in opposite lateral visual fields of the subject.
6. The system for natural objective assessment of visual field function according to claim 5, wherein said sample stimulating optotype and said test stimulating optotype are displayed in the ipsilateral visual field of the subject, and said sample stimulating optotype and said test stimulating optotype are positioned the same.
7. The system for natural objective assessment of visual field function according to claim 1, wherein the parameters of the optotype determined by said calculation module or adjusted by said adjustment module are selected from one or more of the following parameters: the visual target comprises the spatial frequency of the visual targets, the physical strength of the visual targets, the contrast of the visual targets, the shapes of the visual targets, the colors of the visual targets, the number of the visual targets, the orientation of the visual targets, the motion direction of the visual targets, the graphs of the visual targets, the positions of the visual targets, the visual field positions of the visual targets, the display duration of the visual targets and the time interval between every two visual target displays.
8. The system for natural objective assessment of visual field function according to claim 1, wherein said adjusting module adjusts the parameters of said optotype at the next test when the determination result of said determining module is correct three consecutive times, and adjusts the parameters of said optotype at the next test when the determination result of said determining module is wrong; the parameter is the absolute difference of the spatial frequency between the sample stimulus visual target and the test stimulus visual target.
9. The system for natural objective assessment of visual field function according to claim 1, wherein said receiving module receives and records the judgment made by the subject based on the parameters of said sample stimulus visual target and/or said test visual target.
10. The system for natural objective assessment of visual field function according to claim 1, wherein said receiving module receives and records the operation of the subject in determining the order of appearance of the spatially more frequent targets among the sample stimulus targets and the test stimulus targets.
11. A system for natural objective assessment of visual field function according to claim 1, wherein said host control unit further comprises an assessment module for assessing the visual field function of the subject based on the parameters of said optotypes, said operation records and/or said determination results stored in said storage module.
12. The system for natural objective assessment of visual field function according to claim 11, wherein said visual field function is selected from one or more of the following: contrast sensitivity, spatial frequency discrimination threshold, and impaired field of view range.
13. The system for natural objective assessment of visual field function according to claim 11, wherein said assessment is performed by determining a spatial frequency discrimination threshold for the subject at different spatial frequency ratios of said masking stimulus visual target and sample stimulus visual target.
14. The system for natural objective assessment of visual field function according to claim 13, wherein the ratio of the spatial frequency of said masking stimulus visual target and said sample stimulus visual target is 0-2.
15. A system for natural objective assessment of visual field function according to claim 13, wherein the subject's spatial frequency discrimination threshold is: when the sample and test stimulus visuals are displayed in the ipsilateral visual field of the subject and the mask stimulus visual target is displayed in the opposite visual field of the subject, the subject has a threshold limit for discrimination of the absolute difference in spatial frequency between the test stimulus visual target and the sample stimulus visual target.
16. A system for natural objective assessment of perimetrical function according to any of claims 1 to 15, characterized in that said host control unit is a smart device;
the display unit is display equipment; and/or
The human-computer interaction unit is a wireless keyboard, a wired keyboard, a mouse, a touch pad, an operating rod, a handle and/or a track ball.
17. The system for natural objective assessment of visual field function according to claim 16, wherein said display unit is a cathode ray tube display, a liquid crystal display, a light emitting diode display or an organic electroluminescent diode display.
18. The system for natural objective assessment of visual field function according to claim 16, wherein said smart device is a computer, a smart phone, a wearable device and/or a PDA smart terminal.
19. The system for natural objective assessment of visual field function according to claim 18, wherein said computer is a tablet computer.
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| CN108742501B (en) * | 2018-03-23 | 2020-12-04 | 科飞云视（天津）高新科技有限公司 | Method for detecting spatial frequency perception capability based on grating direction discrimination |
| CN108742499B (en) * | 2018-03-23 | 2020-07-10 | 科飞云视（天津）高新科技有限公司 | Detection method of sinusoidal grating perception capability based on brightness modulation |
| CN108670194B (en) * | 2018-03-23 | 2020-09-04 | 科飞云视（天津）高新科技有限公司 | Detection method for perception capability of contrast-modulated motion sinusoidal grating |
| CN109215435B (en) * | 2018-09-28 | 2020-08-28 | 昆明理工大学 | System and method for testing and training effective visual field capability of old driver |
| CN113380366A (en) * | 2021-08-16 | 2021-09-10 | 中国科学院自动化研究所 | Visual field abnormal data evaluation system |
| CN116035523B (en) * | 2023-03-28 | 2023-06-16 | 之江实验室 | Visual contrast sensitivity detection method and device and electronic equipment |
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