CN110934297A - Choline particle and preparation method and application thereof - Google Patents

Choline particle and preparation method and application thereof Download PDF

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Publication number
CN110934297A
CN110934297A CN201911130614.0A CN201911130614A CN110934297A CN 110934297 A CN110934297 A CN 110934297A CN 201911130614 A CN201911130614 A CN 201911130614A CN 110934297 A CN110934297 A CN 110934297A
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choline
granules
preparation
adhesive
granulator
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冯旭俊
黄丽佳
钟建荣
杨善岩
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Hangzhou Minsheng Health Pharmaceutical Co Ltd
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Hangzhou Minsheng Health Pharmaceutical Co Ltd
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    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A23L33/15—Vitamins
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23P—SHAPING OR WORKING OF FOODSTUFFS, NOT FULLY COVERED BY A SINGLE OTHER SUBCLASS
    • A23P10/00—Shaping or working of foodstuffs characterised by the products
    • A23P10/20—Agglomerating; Granulating; Tabletting
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
    • A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs

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  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Food Science & Technology (AREA)
  • Polymers & Plastics (AREA)
  • Mycology (AREA)
  • Health & Medical Sciences (AREA)
  • Nutrition Science (AREA)
  • Medicinal Preparation (AREA)

Abstract

The invention discloses a choline particle and a preparation method and application thereof, and the choline particle comprises the following preparation steps: the method comprises the following steps: crushing choline and sieving the choline with a sieve of 20-100 meshes; step two: dissolving a first binder in water to obtain a binder solution; step three: and (3) mixing the choline treated in the step one with a second adhesive, putting the mixture into a granulator, and adding the adhesive solution obtained in the step two for granulation to obtain choline granules. The invention adopts the technical scheme that the adhesive is dissolved in water, and then the choline is granulated, and the prepared granules have uniform and moderate grain diameter, good fluidity and difficult moisture absorption; the pressed tablet has smooth surface, small difference of tablet weight, good hardness (good friability) and good disintegration.

Description

Choline particle and preparation method and application thereof
Technical Field
The invention relates to the field of functional foods, in particular to choline granules and a preparation method and application thereof.
Background
Choline is an essential component in human and animal bodies, is generally called as a B-vitamin or vitamin B4, is a low-molecular organic compound necessary for maintaining physiological functions in animal bodies, can be synthesized in animal bodies, but is usually added into feed, and is a vitamin with the largest using amount. It can regulate fat metabolism and transformation in animal body, and prevent fat deposition in liver and kidney and tissue degeneration thereof. Accordingly, many nutritionists have included vitamins. Choline has now become a common additive in human food. The federal law in the united states lists choline as a "generally recognized safe" product; the regulations promulgated in the european union in 1991 list choline as a product that is allowed to be added to infant food. In functional foods, choline granules are commonly used, such as choline bitartrate and choline chloride.
Choline bitartrate and choline chloride are commonly used as nutritional supplements and fat-removing agents, and can promote fat metabolism and prevent the accumulation of fat in the liver. As vitamin products, the vitamin product is widely applied to medicines, health products and food nutrition additives. But both have strong hygroscopicity and care should be taken to prevent moisture absorption during use.
Because of the hygroscopic nature of choline granules, in the solid formulation process, the choline granules are usually granulated with ethanol. The ethanol granulation process has some disadvantages: 1. the explosion-proof requirement of the equipment is high, and the process is complex, so the use cost is increased; 2. more fine powder is obtained after ethanol granulation, the granules are easy to absorb moisture and have poor liquidity; 3. the granules have unsmooth surfaces, large difference of tablet weights and low tablet hardness (poor friability) after tabletting.
Disclosure of Invention
The invention aims to provide choline granules and a preparation method and application thereof. The prepared particles have uniform and moderate particle size, good fluidity and difficult moisture absorption; the pressed tablet has smooth surface, small difference of tablet weight, good hardness (good friability) and good disintegration.
The technical scheme adopted by the invention for solving the technical problems is as follows: a preparation method of choline granules comprises the following preparation steps:
the method comprises the following steps: crushing choline and sieving the choline with a sieve of 20-100 meshes;
step two: dissolving a first binder in water to obtain a binder solution;
step three: and (3) mixing the choline treated in the step one with a second adhesive, putting the mixture into a granulator, and adding the adhesive solution obtained in the step two for granulation to obtain choline granules.
The mesh screen is a screen of mesh number, which is the number of mesh openings in a 1 inch length, and the mesh number of the screen is defined as the mesh number of the screen. For example, a 100 mesh screen refers to a screen where material passes through a 100 mesh screen within 1 inch of the screen.
Preferably, the first binder in the second step is hydroxypropyl methylcellulose; and the second adhesive in the second step is one or more of low-substituted hydroxypropyl cellulose, povidone K30 and copovidone.
Preferably, step three further comprises the steps of:
step 1: mixing 2-6 parts of the choline treated in the first step with 1-3 parts of a second adhesive, and putting the mixture of the choline and the second adhesive into a granulator for mixing;
step 2: adding 0.1-2 parts of adhesive solution into a granulator for granulation to obtain wet granules;
and step 3: and (3) putting the wet granules into a fluidized bed for drying to obtain the choline granules.
Preferably, the mixing conditions in step 1 are as follows: the rotating speed of the stirring paddle of the granulator is 100-140 r/min, and the mixture is mixed for 5-15 min. The granulator is the prior art and can be purchased from the market.
Preferably, the conditions for granulation in step 2: mixing for 5-15 min under the condition that the rotating speed of a stirring paddle of a granulator is 100-140 r/min to obtain a mixed material; and (3) sieving the mixed materials through a sieve with the aperture of 5mm, and granulating by a granulator cutter with the rotating speed of 1000-2000 r/min to obtain wet granules.
Preferably, the conditions for drying in step 3: the air inlet temperature is 60-80 ℃, and the drying is stopped when the moisture of the particles reaches (2 +/-0.5)% to obtain a dried material; and taking out the dried material, and sieving the dried material by using a 15-30-mesh sieve to obtain the choline particles.
Preferably, the second step further comprises dissolving the first binder in water to prepare a binder solution with a concentration of 4% to 8%.
Preferably, the choline is choline bitartrate particles or choline chloride particles.
A choline granule is prepared by the preparation method of the choline granule.
Use of choline granules for the preparation of a solid formulation of a functional food.
Compared with the existing product formula and technology in the market, the invention has the following beneficial effects:
1. the particle fluidity is better; the particles are more uniform, the fine powder is less, and the particle size is moderate; the granules are less hygroscopic; the particle compressibility is better.
2. The preparation method is simple, the production process flow is less, the investment is low, the practicability is higher, and the large-scale production is facilitated.
Drawings
FIG. 1 is a process flow diagram of the present invention.
Detailed Description
The present invention will be further described with reference to the accompanying drawings and embodiments.
As shown in fig. 1
Example 1
1. The choline bitartrate is crushed and sieved by a 20-mesh sieve for later use.
2. Hydroxypropyl methylcellulose was dissolved in water to make a 4% solution.
3. Taking 2 parts of crushed and sieved choline bitartrate, adding 1 part of low-substituted hydroxypropyl cellulose, placing the mixture in a high-speed shearing wet mixing granulator, and mixing for 5min at the speed of 100 r/min; adding 0.1 part of hydroxypropyl methyl cellulose solution, and granulating under the conditions: mixing for 5min at the rotating speed of a stirring paddle of 100 r/min; then the materials are sieved by a sieve with the aperture of 5mm, and are granulated by a granulator cutter with the rotating speed of 1000 r/min.
4. And (3) putting the wet granules into a fluidized bed for drying, wherein the drying conditions are as follows: and (3) stopping drying when the air inlet temperature is 60 ℃ and the moisture of the granules reaches (2 +/-0.5)%, taking out the materials, and sieving the materials by a 15-mesh sieve to obtain dry granules.
Example 2
1. The choline bitartrate is crushed and sieved by a 40-mesh sieve for later use.
2. Hydroxypropyl methylcellulose was dissolved in water to make a 6% solution.
3. Taking 4 parts of crushed and sieved choline bitartrate, adding 2 parts of low-substituted hydroxypropyl cellulose, placing in a high-speed shearing wet mixing granulator, and mixing for 10min at the condition of 120 r/min; adding 1 part of hydroxypropyl methyl cellulose solution, and granulating under the conditions: mixing for 10min at the rotating speed of a stirring paddle of 120 r/min; then the materials are sieved by a sieve with the aperture of 5mm, and are granulated by a granulator cutter with the rotating speed of 1500 r/min.
4. And (3) putting the wet granules into a fluidized bed for drying, wherein the drying conditions are as follows: and (3) stopping drying when the air inlet temperature is 70 ℃ and the moisture of the granules reaches (2 +/-0.5)%, taking out the materials, and sieving the materials by a 20-mesh sieve to obtain dry granules.
Example 3
1. The choline bitartrate is crushed and sieved by a 60-mesh sieve for later use.
2. Hydroxypropyl methylcellulose was dissolved in water to make a 8% solution.
3. Taking 6 parts of crushed and sieved choline bitartrate, adding 3 parts of low-substituted hydroxypropyl cellulose, placing the mixture in a high-speed shearing wet mixing granulator, and mixing for 15min under the condition of 140 r/min; adding 2 parts of hydroxypropyl methyl cellulose solution, and granulating under the conditions: mixing for 15min at the rotating speed of the stirring paddle of 140 r/min; then the materials are sieved by a sieve with the aperture of 5mm and granulated by a granulator cutter with the rotating speed of 2000 r/min.
4. And (3) putting the wet granules into a fluidized bed for drying, wherein the drying conditions are as follows: and (3) stopping drying when the air inlet temperature is 80 ℃, and when the moisture of the granules reaches (2 +/-0.5)%, taking out the materials, and sieving by a 30-mesh sieve to obtain dry granules.
Example 4
1. The choline chloride is crushed and sieved by a 40-mesh sieve for standby.
2. Hydroxypropyl methylcellulose was dissolved in water to make a 6% solution.
3. Taking 4 parts of crushed and sieved choline chloride, adding 2 parts of low-substituted hydroxypropyl cellulose, placing the mixture in a high-speed shearing wet mixing granulator, and mixing for 10min at the condition of 120 r/min; adding 1 part of hydroxypropyl methyl cellulose solution, and granulating under the conditions: mixing for 10min at the rotating speed of a stirring paddle of 120 r/min; then the materials are sieved by a sieve with the aperture of 5mm and granulated by a granulator cutter with the rotating speed of 1500 r/min.
4. And (3) putting the wet granules into a fluidized bed for drying, wherein the drying conditions are as follows: and (3) stopping drying when the air inlet temperature is 70 ℃ and the moisture of the granules reaches (2 +/-0.5)%, taking out the materials, and sieving the materials by a 20-mesh sieve to obtain dry granules.
Example 5
1. The choline bitartrate is crushed and sieved by a 40-mesh sieve for later use.
2. Hydroxypropyl methylcellulose was dissolved in water to make a 6% solution.
3. Taking 4 parts of crushed and sieved choline bitartrate, adding 2 parts of hydroxypropyl cellulose, placing in a high-speed shearing wet mixing granulator, and mixing for 10min at the condition of 120 r/min; adding 1 part of hydroxypropyl methyl cellulose solution, and granulating under the conditions: mixing for 10min at the rotating speed of a stirring paddle of 120 r/min; then the materials are sieved by a sieve with the aperture of 5mm, and are granulated by a granulator cutter with the rotating speed of 1500 r/min.
4. And (3) putting the wet granules into a fluidized bed for drying, wherein the drying conditions are as follows: and (3) stopping drying when the air inlet temperature is 70 ℃ and the moisture of the granules reaches (2 +/-0.5)%, taking out the materials, and sieving the materials by a 20-mesh sieve to obtain dry granules.
Example 6
1. The choline bitartrate is crushed and sieved by a 40-mesh sieve for later use.
2. Hydroxypropyl methylcellulose was dissolved in water to make a 6% solution.
3. Taking 4 parts of crushed and sieved choline bitartrate, adding two parts of povidone K30, placing in a high-speed shearing wet mixing granulator, and mixing for 10min at the condition of 120 r/min; adding 1 part of hydroxypropyl methyl cellulose solution, and granulating under the conditions: mixing for 10min at the rotating speed of a stirring paddle of 120 r/min; then the materials are sieved by a sieve with the aperture of 5mm, and are granulated by a granulator cutter with the rotating speed of 1500 r/min.
4. And (3) putting the wet granules into a fluidized bed for drying, wherein the drying conditions are as follows: and (3) stopping drying when the air inlet temperature is 70 ℃ and the moisture of the granules reaches (2 +/-0.5)%, taking out the materials, and sieving the materials by a 20-mesh sieve to obtain dry granules.
Example 7
1. The choline bitartrate is crushed and sieved by a 40-mesh sieve for later use.
2. Hydroxypropyl methylcellulose was dissolved in water to make a 6% solution.
3. Taking 4 parts of crushed and sieved choline bitartrate, adding 2 parts of copovidone, placing in a high-speed shearing wet mixing granulator, and mixing for 10min at the condition of 120 r/min; adding 1 part of hydroxypropyl methyl cellulose solution, and granulating under the conditions: mixing for 10min at the rotating speed of a stirring paddle of 120 r/min; then the materials are sieved by a sieve with the aperture of 5mm, and are granulated by a granulator cutter with the rotating speed of 1500 r/min.
4. And (3) putting the wet granules into a fluidized bed for drying, wherein the drying conditions are as follows: and (3) stopping drying when the air inlet temperature is 70 ℃ and the moisture of the granules reaches (2 +/-0.5)%, taking out the materials, and sieving the materials by a 20-mesh sieve to obtain dry granules.
Comparative example 1
1. The choline bitartrate is crushed and sieved by a 40-mesh sieve for later use.
2. Polyvinylpyrrolidone was dissolved in water to make a 6% solution.
3. Taking 4 parts of crushed and sieved choline bitartrate, adding 2 parts of low-substituted hydroxypropyl cellulose, placing in a high-speed shearing wet mixing granulator, and mixing for 10min at the condition of 120 r/min; adding 1 part of polyvinylpyrrolidone solution, granulating, wherein the granulating conditions are as follows: mixing for 10min at the rotating speed of a stirring paddle of 120 r/min; then the materials are sieved by a sieve with the aperture of 5mm, and are granulated by a granulator cutter with the rotating speed of 1500 r/min.
4. And (3) putting the wet granules into a fluidized bed for drying, wherein the drying conditions are as follows: and (3) stopping drying when the air inlet temperature is 70 ℃ and the moisture of the granules reaches (2 +/-0.5)%, taking out the materials, and sieving the materials by a 20-mesh sieve to obtain dry granules.
Comparative example 2
1. The choline bitartrate is crushed and sieved by a 40-mesh sieve for later use.
2. Dissolving polyvinylpyrrolidone in 50% ethanol solution to obtain ethanol-water solution with polyvinylpyrrolidone concentration of 6%.
3. Taking 4 parts of crushed and sieved choline bitartrate, adding 2 parts of low-substituted hydroxypropyl cellulose, placing in a high-speed shearing wet mixing granulator, and mixing for 10min at the condition of 120 r/min; adding 1 part of polyvinylpyrrolidone-ethanol-water solution, granulating, wherein the granulating conditions are as follows: mixing for 10min at the rotating speed of a stirring paddle of 120 r/min; then the materials are sieved by a sieve with the aperture of 5mm, and are granulated by a granulator cutter with the rotating speed of 1500 r/min.
4. And (3) putting the wet granules into a fluidized bed for drying, wherein the drying conditions are as follows: and (3) stopping drying when the air inlet temperature is 70 ℃ and the moisture of the granules reaches (2 +/-0.5)%, taking out the materials, and sieving the materials by a 20-mesh sieve to obtain dry granules.
Comparative example 3
1. The choline bitartrate is crushed and sieved by a 40-mesh sieve for later use.
2. Dissolving polyvinylpyrrolidone in 50% ethanol solution to obtain ethanol-water solution with polyvinylpyrrolidone concentration of 6%.
3. Taking 4 parts of crushed and sieved choline bitartrate, adding 2 parts of microcrystalline cellulose, placing in a high-speed shearing wet mixing granulator, and mixing for 10min at the condition of 120 r/min; adding 1 part of polyvinylpyrrolidone-ethanol-water solution, granulating, wherein the granulating conditions are as follows: mixing for 10min at the rotating speed of a stirring paddle of 120 r/min; then the materials are sieved by a sieve with the aperture of 5mm, and are granulated by a granulator cutter with the rotating speed of 1500 r/min.
4. And (3) putting the wet granules into a fluidized bed for drying, wherein the drying conditions are as follows: and (3) stopping drying when the air inlet temperature is 70 ℃ and the moisture of the granules reaches (2 +/-0.5)%, taking out the materials, and sieving by a 20-mesh sieve to obtain dry granules.
And (3) detection:
first, particle flowability measurement
Test method 1
The bulk density was measured according to the method specified in astm d 7481; tap density was measured according to the method specified in GB 5162; the carr coefficient is (tap density-bulk density)/tap density × 100%.
2 results
As shown in table 1, the carr coefficients of the choline particles prepared in examples 1 to 7 are all less than each comparative example and are all less than 16%, which indicates that the mobility of the choline particles prepared in examples is better than that of the comparative examples; wherein the carr factor of the choline granules prepared in both example 2 and example 3 was less than 14%.
Table 1 choline granules flowability measurement results (n-3,
Figure BDA0002278189720000061
)
Figure BDA0002278189720000062
note: evaluation criteria for Carr coefficient: the fluidity of less than or equal to 10 percent is very good, the fluidity of 11 to 15 percent is good, the fluidity of 16 to 20 percent is good, the fluidity of 21 to 25 percent is general, the fluidity of 26 to 31 percent is poor, the fluidity of 32 to 37 percent is very poor, and the fluidity of more than or equal to 38 percent is very poor.
3 conclusion
As can be seen from the test results, the choline granules prepared in the examples of the present invention have better flowability.
Secondly, detecting the particle size distribution of the particles
Test method 1
Selecting 16-mesh (1.18mm), 18-mesh (1.00mm), 20-mesh (0.850mm), 30-mesh (0.6mm), 40-mesh (0.425mm), 60-mesh (0.250mm), 80-mesh (0.180mm) and 100-mesh (0.150mm) screens, installing the screens on a vibrating screen according to the sequence of screen aperture from small to large, weighing about 100g of particles to be tested, precisely weighing, placing the particles on a top screen, vibrating for 5min at the amplitude of 1.0mm, precisely weighing the mass of the particles retained on each screen after the test is finished, and calculating the retention percentage of the particles on each screen.
2 results
From particle size distribution data, the particle sizes of the particles prepared in the embodiments 1 to 7 of the invention are mainly distributed in 30 to 60 meshes, and are all over 80 percent, which is much higher than that of the comparative example.
Table 2 results of particle size distribution measurement (n-3,
Figure BDA0002278189720000071
)
Figure BDA0002278189720000072
3 conclusion
The test result shows that the method provided by the embodiment of the invention has good granulation effect, less generated fine powder and concentrated and distributed particles of 30-60 meshes.
Thirdly, evaluation of moisture absorption of particles (refer to GB/T6102.1)
Test method 1
Accurately weighing a certain mass of sample to be measured, and recording as m0Drying in an oven at 105 + -2 deg.C to constant weight, which is recorded as m1. The moisture regain R is calculated according to the following formula.
Figure BDA0002278189720000073
In the formula:
r-moisture regain,%;
m0-mass before drying of the sample, g;
m1-mass after drying of the sample, g.
2 results
As shown in Table 3, the granules prepared in the examples of the present invention had a moisture regain of not higher than 6%, which was significantly lower than that of the comparative example.
Table 3 moisture regain measurements of different samples (n-5,
Figure BDA0002278189720000081
)
Figure BDA0002278189720000082
3 conclusion
The test results show that the particles prepared by the method have low hygroscopicity and are beneficial to practical application.
Fourth, evaluation of compressibility of the pellet
Test method 1
Taking samples to be tested, respectively adding 2% of magnesium stearate, mixing for 10min at a rotating speed of 20r/min, tabletting by using a 14mm circular punch die, setting the weight of the tablets to be 0.75g, respectively observing the appearance of the tablets after tabletting, and determining the hardness, the disintegration, the friability and the difference of the weight of the tablets.
The hardness method comprises the following steps: taking 10 tablets to be measured, measuring the hardness by using a hardness tester, and taking an average value; the disintegration property was measured according to a method defined in pharmacopoeia of the people's republic of china (2015 edition of the general rules of the four departments); the friability was measured according to the method specified in pharmacopoeia of the people's republic of china (2015 edition of the general rules of the four departments); the difference in tablet weight was measured according to the method defined in pharmacopoeia of the people's republic of china (2015 edition of the general rules of the four parts, "tablets [ weight difference ]").
2 results
After the particles of the examples are tabletted, no sticking and cracking phenomena are found, and the surface is smooth and clean; the comparative example particles had no sticking, slight sticking and cracking, and had a non-smooth surface.
As shown in table 4, the tablet hardness of the granules prepared in examples 1 to 7 was determined to be more than 81N after tabletting, and the friability was not higher than 0.06%, which is significantly better than that of the comparative example, indicating better compressibility; and has better disintegration and smaller tablet weight difference after tabletting.
Table 4 results of evaluation of compressibility of the granules (n 10,
Figure BDA0002278189720000083
)
Figure BDA0002278189720000084
Figure BDA0002278189720000091
3 conclusion
As can be seen from the test results, the granules prepared by the embodiment of the invention have better tabletting effect.
The embodiments are described in a progressive manner in the specification, each embodiment focuses on differences from other embodiments, and the same and similar parts among the embodiments are referred to each other. It should be understood that the terms used in the present specification and the appended claims should not be construed as limited to general and dictionary meanings, but interpreted based on the meanings and concepts corresponding to technical aspects of the present invention on the basis of the principle that the inventor is allowed to define terms appropriately for the best explanation. Accordingly, the description proposed herein is just a preferable example for the purpose of illustrations only, not intended to limit the scope of the invention, so it should be understood that other equivalents and modifications could be made thereto without departing from the spirit and scope of the invention.
The previous description of the disclosed embodiments is provided to enable any person skilled in the art to make or use the present invention. Various modifications to these embodiments will be readily apparent to those skilled in the art, and the generic principles defined herein may be applied to other embodiments without departing from the spirit or scope of the invention. Thus, the present invention is not intended to be limited to the embodiments shown herein but is to be accorded the widest scope consistent with the principles and novel features disclosed herein.

Claims (10)

1. A preparation method of choline granules is characterized by comprising the following steps: the preparation method comprises the following preparation steps:
the method comprises the following steps: crushing choline and sieving the choline with a sieve of 20-100 meshes;
step two: dissolving a first binder in water to obtain a binder solution;
step three: and (3) mixing the choline treated in the step one with a second adhesive, putting the mixture into a granulator, and adding the adhesive solution obtained in the step two for granulation to obtain choline granules.
2. A process for the preparation of choline granules according to claim 1, characterized in that: the first adhesive in the step two is hydroxypropyl methyl cellulose; and the second adhesive in the second step is one or more of low-substituted hydroxypropyl cellulose, povidone K30 and copovidone.
3. A process for the preparation of choline granules according to claim 1 or 2, characterized in that: the third step also comprises the following steps:
step 1: mixing 2-6 parts of the choline treated in the first step with 1-3 parts of a second adhesive, and putting the mixture of the choline and the second adhesive into a granulator for mixing;
step 2: adding 0.1-2 parts of adhesive solution into a granulator for granulation to obtain wet granules;
and step 3: and (3) putting the wet granules into a fluidized bed for drying to obtain the choline granules.
4. A process for the preparation of choline granules according to claim 3, characterized in that: conditions for mixing in step 1: the rotating speed of the stirring paddle of the granulator is 100-140 r/min, and the mixture is mixed for 5-15 min.
5. A process for the preparation of choline granules according to claim 3, characterized in that: granulation conditions in step 2: mixing for 5-15 min under the condition that the rotating speed of a stirring paddle of a granulator is 100-140 r/min to obtain a mixed material; and (3) sieving the mixed materials through a sieve with the aperture of 5mm, and granulating by a granulator cutter with the rotating speed of 1000-2000 r/min to obtain wet granules.
6. A process for the preparation of choline granules according to claim 3, characterized in that: drying conditions in step 3: the air inlet temperature is 60-80 ℃, and the drying is stopped when the moisture of the particles reaches (2 +/-0.5)% to obtain a dried material; and taking out the dried material, and sieving the dried material by using a 15-30-mesh sieve to obtain the choline particles.
7. A process for the preparation of choline granules according to claim 1 or 2 or 4 or 5 or 6, characterized in that: and step two, dissolving the first adhesive in water to prepare an adhesive solution with the concentration of 4-8%.
8. A process for the preparation of choline granules according to claim 7, characterized in that: the choline is choline bitartrate or choline chloride.
9. A choline particle, characterized by: is prepared by the preparation method of the choline granules.
10. Use of choline granules, characterized in that: the choline granules are used for preparing functional food solid preparations.
CN201911130614.0A 2019-11-19 2019-11-19 Choline particle and preparation method and application thereof Pending CN110934297A (en)

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN112655969A (en) * 2021-03-15 2021-04-16 江苏艾兰得营养品有限公司 Choline bitartrate granules, tablets containing same and preparation method
CN113877681A (en) * 2021-09-09 2022-01-04 内蒙古自治区农牧业科学院 Rumen-bypass 5-hydroxytryptamine coating device and coating method
CN114569631A (en) * 2022-02-08 2022-06-03 杭州民生健康药业股份有限公司 Moisture-resistant vitamin mineral tablet and moisture-resistant treatment method thereof

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CN103110588A (en) * 2012-11-14 2013-05-22 江苏江山制药有限公司 Production method of vitamin B6 granules
CN103110515A (en) * 2012-11-14 2013-05-22 江苏江山制药有限公司 Glucosamine potassium sulfate particle production method
KR20160054216A (en) * 2014-11-06 2016-05-16 환인제약 주식회사 Pharmaceutical tablet comprising Choline Alphoscerate and method for manufacturing the same

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CN103110588A (en) * 2012-11-14 2013-05-22 江苏江山制药有限公司 Production method of vitamin B6 granules
CN103110515A (en) * 2012-11-14 2013-05-22 江苏江山制药有限公司 Glucosamine potassium sulfate particle production method
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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN112655969A (en) * 2021-03-15 2021-04-16 江苏艾兰得营养品有限公司 Choline bitartrate granules, tablets containing same and preparation method
CN113877681A (en) * 2021-09-09 2022-01-04 内蒙古自治区农牧业科学院 Rumen-bypass 5-hydroxytryptamine coating device and coating method
CN113877681B (en) * 2021-09-09 2022-11-01 内蒙古自治区农牧业科学院 Rumen-bypass 5-hydroxytryptamine coating device and coating method
CN114569631A (en) * 2022-02-08 2022-06-03 杭州民生健康药业股份有限公司 Moisture-resistant vitamin mineral tablet and moisture-resistant treatment method thereof

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