CN110927085A - Blood sample detection system - Google Patents
Blood sample detection system Download PDFInfo
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- CN110927085A CN110927085A CN201911283082.4A CN201911283082A CN110927085A CN 110927085 A CN110927085 A CN 110927085A CN 201911283082 A CN201911283082 A CN 201911283082A CN 110927085 A CN110927085 A CN 110927085A
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- detection
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- flow channel
- circular groove
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/17—Systems in which incident light is modified in accordance with the properties of the material investigated
- G01N21/25—Colour; Spectral properties, i.e. comparison of effect of material on the light at two or more different wavelengths or wavelength bands
- G01N21/31—Investigating relative effect of material at wavelengths characteristic of specific elements or molecules, e.g. atomic absorption spectrometry
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/01—Arrangements or apparatus for facilitating the optical investigation
Abstract
The invention relates to a blood sample detection system, which comprises a shell and an electrode card; the shell is a box body with an opening on one surface, two bulges are arranged on the outer side of the bottom surface corresponding to the opening, and a through hole is formed in each bulge; the through hole penetrates through the protrusion and the bottom surface; a flow channel from one bulge to the other bulge is arranged on the inner side surface of the bottom surface; a first circular groove part is arranged at the starting end of the flow channel, a second circular groove part is arranged at the ending end of the flow channel, and the diameter of the first circular groove part is larger than the maximum width of the rest part of the flow channel; the first circular groove portion is connected with one of the raised through holes through a flow channel.
Description
Technical Field
The invention relates to a system for detecting a blood sample.
Background
Blood sample testing has a test instrument that is a kit for the test instrument and generally requires a prepared blood sample to be provided. Whereas standard blood samples require bubble-free. Thus, the equipment matched with the detection instrument needs to be capable of providing a blood sample and detecting whether the blood sample has bubbles or not. CN102657903B discloses a bubble monitoring system for blood purification, which can monitor whether a sample is blood or not and perform monitoring whether bubbles exist or not. However, the device is intended for testing only one part of a blood sample in flow, which may harbor bubbles that are not easily detectable in some local tests.
Disclosure of Invention
In view of this, the present invention provides a system for detecting a blood sample, which can provide a blood sample for a detection instrument, and can provide a blood sample flow channel for the detection instrument to detect the blood sample, so as to ensure that the blood sample has no air bubbles.
The specific technical scheme of the invention is as follows:
a blood sample detection system, the system comprising a housing and an electrode card;
the shell is a box body with an opening on one surface, two bulges are arranged on the outer side of the bottom surface corresponding to the opening, and a through hole is formed in each bulge; the through hole penetrates through the protrusion and the bottom surface;
a flow channel from one bulge to the other bulge is arranged on the inner side surface of the bottom surface;
a first circular groove part is arranged at the starting end of the flow channel, a second circular groove part is arranged at the ending end of the flow channel, and the diameter of the first circular groove part is larger than the maximum width of the rest part of the flow channel; the first circular groove part is connected with the through hole of one bulge through a flow channel;
the flow channel comprises a first detection channel, a redistribution channel and a second detection channel; the first detection track is connected to the first circular groove;
pits are arranged on two sides of the first circular groove part; a plurality of pits are uniformly arranged on the two sides of the first detection track; the redistribution trace is connected with the first detection trace;
the second detection channel is connected with the redistribution channel;
pits are uniformly arranged on the two sides of the second detection track;
at least two mounting columns are arranged on the inner side of the shell and matched with the mounting holes on the electrode card;
a plurality of electrodes are arranged on the central axis of the front surface of the electrode card, and a light source and a photoelectric sensor are arranged on two sides of the plurality of electrodes and correspond to the positions of the pits on two sides of each of the first detection channel and the second detection channel; the light sources and the photoelectric sensors are in one-to-one correspondence;
the back surface of the electrode card is provided with a heating copper foil, two rows of electrode contact points are arranged on two sides of the heating copper foil, a control unit is arranged beside one row of electrode contact points, and a resistor is arranged beside the other row of electrode contact points; an electrode contact point is in contact with the electrode;
when the electrode contact point receives current from a detection instrument, the control unit controls the heating copper foil on the electrode card to be heated to a set temperature, and all light sources and the photoelectric sensors on the electrode card are started, at the moment, a blood sample is injected into the through hole from a protrusion on the shell and passes through the first circular groove channel, the redistribution channel and the second detection channel, and the photoelectric sensors can judge whether the blood sample passes through and whether bubbles exist in the blood sample according to received signals when the blood sample passes through the corresponding light sources through the channel due to different absorption rates of the blood sample, common liquid and air;
the electrode card is provided with a mounting hole matched with the mounting column;
the front of electrode card be with the one side of casing contact, have the insulating layer on the front, the insulating layer avoids the electrode.
Further, the flow channel is a groove-shaped flow channel.
Furthermore, the peripheral surface of the bulge is provided with a groove, and a sealing ring can be installed in the groove.
Further, light sources are arranged at positions corresponding to two rows of pits close to the electrode 33, and photoelectric sensors are arranged at positions corresponding to two rows of pits far from the electrode.
Furthermore, a second circular groove part is arranged at the end of the flow channel, the diameter of the second circular groove part is larger than the maximum width of the rest part of the flow channel, and the second circular groove part is connected with the other convex through hole through the flow channel. Pits are also arranged on two sides of the second circular groove part.
Further, first detection way, redistribution way and second detection way parallel arrangement are in the inboard of casing, connect through semi-circular runner between first detection way and the redistribution way, redistribution way with the second detects and also connects through semi-circular runner between the way.
Further, the first and second detection tracks are equal in width, and the redistribution track is slightly larger in width than the first and second detection tracks.
Further, the width of the redistribution trace is 0.3mm greater than the first detection trace.
Through the technical scheme, the blood sample can be detected in the whole flow channel, and the air bubbles hidden in the blood sample can be exposed due to the bent flow channel, so that the detection of the instrument is not influenced.
Drawings
Fig. 1 is an exploded view of the structure of the present invention.
Fig. 2 is a schematic structural diagram of the housing of the present invention.
Fig. 3 is a front structural view of an electrode card of the present invention.
Fig. 4 is a back structural view of the electrode card of the present invention.
FIG. 5 is a schematic view of an insulating layer of the electrode card of the present invention.
Fig. 6 is a schematic view of the present invention after application of an insulating layer.
Fig. 7 is an assembly view of the present invention.
Detailed Description
In order to make the objects, technical solutions and advantages of the embodiments of the present invention clearer, the technical solutions in the embodiments of the present invention will be clearly and completely described below, and it is obvious that the described embodiments are a part of the embodiments of the present invention, but not all of the embodiments. All other embodiments, which can be derived by a person skilled in the art from the embodiments given herein without making any creative effort, shall fall within the protection scope of the present invention.
The terminology used in the embodiments of the invention is for the purpose of describing particular embodiments only and is not intended to be limiting of the invention. As used in the examples of the present invention and the appended claims, the singular forms "a", "an", and "the" are intended to include the plural forms as well, and "a" and "an" generally include at least two, but do not exclude at least one, unless the context clearly dictates otherwise.
It should be understood that the term "and/or" as used herein is merely one type of association that describes an associated object, meaning that three relationships may exist, e.g., a and/or B may mean: a exists alone, A and B exist simultaneously, and B exists alone. In addition, the character "/" herein generally indicates that the former and latter related objects are in an "or" relationship.
It should be understood that although the terms first, second, third, etc. may be used to describe … … in embodiments of the present invention, these … … should not be limited to these terms. These terms are used only to distinguish … …. For example, the first … … can also be referred to as the second … … and similarly the second … … can also be referred to as the first … … without departing from the scope of embodiments of the present invention.
The words "if", as used herein, may be interpreted as "at … …" or "at … …" or "in response to a determination" or "in response to a detection", depending on the context. Similarly, the phrases "if determined" or "if detected (a stated condition or event)" may be interpreted as "when determined" or "in response to a determination" or "when detected (a stated condition or event)" or "in response to a detection (a stated condition or event)", depending on the context.
It is also noted that the terms "comprises," "comprising," or any other variation thereof, are intended to cover a non-exclusive inclusion, such that a good or system that comprises a list of elements does not include only those elements but may include other elements not expressly listed or inherent to such good or system. Without further limitation, an element defined by the phrase "comprising an … …" does not exclude the presence of other like elements in a commodity or system that includes the element.
As shown in fig. 1, the whole detection system comprises a shell 1 and an electrode card 2. The back of the shell 1 is provided with a bulge 3, a through hole is arranged in the bulge 3, the peripheral surface of the bulge 3 is provided with a groove, and a sealing ring can be arranged in the groove. The system for detecting is matched with a detector for use, and the bulge 3 can be inserted into the detector for matching and installation. For the detection of blood samples, no standardized detection products exist at present, and all detection devices are different. The present application aims to design a compact, standardized device capable of detecting bubbles.
As shown in fig. 2, the casing 1 is a box body with an opening on one side, two protrusions 3 are arranged on the outer side of the bottom surface corresponding to the opening, through holes are arranged in the protrusions 3, and the through holes penetrate through the protrusions and the bottom surface.
On the inner side of the bottom surface, a flow channel 14 is arranged from one projection to the other projection, and the flow channel 14 is a groove-shaped flow channel.
A first circular groove 12 is provided at the beginning end of the flow channel 14, and a second circular groove 15 is provided at the end, the diameters of the first and second circular grooves being larger than the maximum width of the rest of the flow channel. The first circular groove part is connected with one of the raised through holes through a flow channel, and the second circular groove part is connected with the other raised through hole through a flow channel. The existence of the first circular groove part can buffer the blood sample, and the condition that the blood sample is insufficient is avoided.
The flow channel includes a first detection channel 13, a redistribution channel, and a second detection channel 16.
The first detection track 13 is connected to the first circular groove portion. Pits 11 are arranged on two sides of the first circular groove part; a plurality of pits are also uniformly arranged on both sides of the first detection track 13.
The redistribution trace connects the first detection trace 13.
The second detection lane 16 connects the redistribution lanes. Pits 11 are uniformly arranged on two sides of the second detection track 16, and pits 11 are also arranged on two sides of the second circular groove.
At least two mounting posts 17 are also provided on the inside of the housing for mounting the electrode card 2.
Preferably, first detection way 13, redistribution way and second detection way parallel arrangement are again the inboard of casing, connect through semi-circular runner between first detection way 13 and the redistribution way, redistribution way with also connect through semi-circular runner between the second detection way.
Preferably, the first and second detection tracks are equal in width, and the redistribution track is slightly larger in width than the first and second detection tracks. Thus, when a blood sample flowing into the channel flow channel from one convex through hole, passing through the first circular groove part and the first detection channel reaches the redistribution channel, the blood sample can be finely redistributed in the redistribution channel under the extrusion of the second detection channel which is narrower than the redistribution channel, and bubbles which cannot be detected in the first detection channel can be conveniently displayed in the redistribution channel. Said slightly larger is not larger than 0.5 mm. In fact, it should not be too large, and if it is too large, bubbles may be increased due to the larger space when the air flows from the first detection channel, but the bubbles may be removed as the flow continues. Applicant sets a diameter increase of 0.5mm and tests several times without finding any increased bubbles, which may preferably be 0.3 mm.
As shown in fig. 3, a plurality of electrodes 33 are disposed on a central axis of the front surface of the electrode card 3, and a light source 31 and a photosensor 32 are disposed on two sides of the plurality of electrodes 33, corresponding to the positions of the pits on two sides of each of the first detection track 13 and the second detection track 16. The light sources 31 and photosensors are shown in a one-to-one correspondence.
Preferably, the light sources 31 are disposed at positions corresponding to two rows of pits close to the electrode 33, and the photosensors are disposed at positions corresponding to two rows of pits far from the electrode 33.
As shown in fig. 4, a heating copper foil 35 is provided on the back surface of the electrode card 3, and two rows of electrode contacts 36 are provided on both sides of the heating copper foil, wherein a memory 34 is provided beside one row of electrode contacts, and a resistor 37 is provided beside the other row of electrode contacts. An electrode contact 35 is in contact with the electrode 33. The electrode card is provided with a mounting hole 38 matched with the mounting column 17. Resistor 37 is preferably a temperature controlled resistor. Of course, the memory may be provided on the instrument instead of the memory.
As shown in fig. 5, the front surface of the electrode card is a surface contacting with the housing, and the front surface has an insulating layer thereon, which avoids the electrodes 33. The insulating layer is a covering insulating layer or a coating insulating layer.
The cover insulating layer or the coating insulating layer has three layers.
When the insulating layer is a coating insulating layer, a coating layer with a thickness of 0.3mm is coated on each place of the front surface, and the three layers are 0.9mm in total.
When the insulating layer is a cover insulating layer, the insulating layer is provided according to the shape of the front surface. Thus, a light source and a photosensor may be included.
As shown in fig. 6, at the electrode 33, three layers of the insulating layers are distributed in a step-rotating manner, so that the outer side of each electrode 33 has three steps. Thus, three layers of point liquid can be realized during point liquid of the re-electrode.
As shown in fig. 7, the mounting holes 38 are aligned with the mounting posts 17, so that the electrode card can be mounted in cooperation with the housing, and the electrode card is integrally located in the interior of the housing.
The operation process of the invention is as follows:
in the system installation channel detection instrument, a sealing ring is in close contact with a clamping position on the instrument, meanwhile, a corresponding thimble on the instrument is connected with an electrode contact point on the back of an electrode card, and then the instrument controls the heating copper foil on the electrode card to be heated to a fixed temperature. At the moment, the blood sample is injected into the through hole from the protrusion on the shell, and meanwhile, the light source and the photoelectric sensor on the electrode card are controlled to be started by the instrument.
If the blood contains air bubbles, when the blood flows through the light source beside the first circular groove part, the photoelectric sensor corresponding to the light source can detect the air bubbles, the control unit on the instrument records the air bubbles, and the counter is increased by 1. The photoelectric sensors on two sides of the first detection channel, including the photoelectric sensors beside the first circular groove part, count N photoelectric sensors, and then, the counter counts N.
And the two sides of the second detection channel comprise N photoelectric sensors beside the second circular groove part.
If no new bubble appears when the channel is redistributed, then every time a photoelectric sensor detects a channel bubble, the counter is decremented by 1.
When the blood sample fills the flow channel between the first and last photosensors and the bubble counter is 0. At this point, no air bubbles are present in the blood, and the instrument turns on the electrodes to detect the blood sample in the redistribution channel.
If new bubbles may occur for various reasons when the channel is redistributed, the counter value is less than 0 when the number of counters is decreased, and the counter value is less than 0 for at least a certain period of time during the blood flow period T even if new bubbles are generated.
Once there is a moment when the counter is less than 0, the counter is controlled to zero and the transport of the blood sample is suspended until the blood in the flow channel is completely removed from the other through hole.
Through the technical scheme, the blood sample can be detected in the whole flow channel, and the air bubbles hidden in the blood sample can be exposed due to the bent flow channel, so that the detection of the instrument is not influenced.
Finally, it should be noted that: the above examples are only intended to illustrate the technical solution of the present invention, but not to limit it; although the present invention has been described in detail with reference to the foregoing embodiments, it will be understood by those of ordinary skill in the art that: the technical solutions described in the foregoing embodiments may still be modified, or some technical features may be equivalently replaced; and such modifications or substitutions do not depart from the spirit and scope of the corresponding technical solutions of the embodiments of the present invention.
Claims (9)
1. A blood sample detection system, the system comprising a housing and an electrode card; the method is characterized in that:
the shell is a box body with an opening on one surface, two bulges are arranged on the outer side of the bottom surface corresponding to the opening, and a through hole is formed in each bulge; the through hole penetrates through the protrusion and the bottom surface;
a flow channel from one bulge to the other bulge is arranged on the inner side surface of the bottom surface;
a first circular groove part is arranged at the starting end of the flow channel, a second circular groove part is arranged at the ending end of the flow channel, and the diameter of the first circular groove part is larger than the maximum width of the rest part of the flow channel; the first circular groove part is connected with the through hole of one bulge through a flow channel;
the flow channel comprises a first detection channel, a redistribution channel and a second detection channel; the first detection track is connected to the first circular groove;
pits are arranged on two sides of the first circular groove part; a plurality of pits are uniformly arranged on the two sides of the first detection track;
the redistribution trace is connected with the first detection trace;
the second detection channel is connected with the redistribution channel;
pits are uniformly arranged on the two sides of the second detection track;
at least two mounting columns are arranged on the inner side of the shell and matched with the mounting holes on the electrode card;
a plurality of electrodes are arranged on the central axis of the front surface of the electrode card, and a light source and a photoelectric sensor are arranged on two sides of the plurality of electrodes and correspond to the positions of the pits on two sides of each of the first detection channel and the second detection channel; the light sources and the photoelectric sensors are in one-to-one correspondence;
the back surface of the electrode card is provided with a heating copper foil, two rows of electrode contact points are arranged on two sides of the heating copper foil, a control unit is arranged beside one row of electrode contact points, and a resistor is arranged beside the other row of electrode contact points; an electrode contact point is in contact with the electrode;
when the electrode contact point receives current from a detection instrument, the control unit controls the heating copper foil on the electrode card to be heated to a set temperature, and all light sources and the photoelectric sensors on the electrode card are started, at the moment, a blood sample is injected into the through hole from a protrusion on the shell and passes through the first circular groove channel, the redistribution channel and the second detection channel, and the photoelectric sensors can judge whether the blood sample passes through and whether bubbles exist in the blood sample according to received signals when the blood sample passes through the corresponding light sources through the channel due to different absorption rates of the blood sample, common liquid and air;
the electrode card is provided with a mounting hole matched with the mounting column;
the front of electrode card be with the one side of casing contact, have the insulating layer on the front, the insulating layer avoids the electrode.
2. The system of claim 1, wherein the flow channel is a slotted flow channel.
3. The system of claim 1, wherein the outer periphery of the protrusion is provided with a groove, and a sealing ring can be mounted in the groove.
4. The system of claim 1, wherein the light sources are disposed at positions corresponding to two rows of pits near the electrode, and the photosensors are disposed at positions corresponding to two rows of pits far from the electrode.
5. The system of claim 1, wherein a second circular groove portion having a diameter greater than the maximum width of the remaining portion of the flow channel is provided at the end of the flow channel, the second circular groove portion being connected with the through hole of the other protrusion through the flow channel; pits are also arranged on two sides of the second circular groove part.
6. The system of claim 1, wherein the first, redistribution and second detection channels are disposed in parallel inside the housing, the first and redistribution channels being connected by a semicircular flow channel, the redistribution channel being connected by a semicircular flow channel to the second detection channel.
7. The system of claim 6, wherein the first and second detection traces are equal in width and the redistribution trace has a width slightly greater than the first and second detection traces.
8. The system of claim 7, wherein the redistribution trace has a width that is 0.3mm greater than the first detection trace.
9. The system of claim 1, wherein at each electrode, the three layers of the insulating layer are stepped such that the outside of each electrode has three steps.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201911283082.4A CN110927085A (en) | 2019-12-13 | 2019-12-13 | Blood sample detection system |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201911283082.4A CN110927085A (en) | 2019-12-13 | 2019-12-13 | Blood sample detection system |
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| Publication Number | Publication Date |
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| CN110927085A true CN110927085A (en) | 2020-03-27 |
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| CN201911283082.4A Pending CN110927085A (en) | 2019-12-13 | 2019-12-13 | Blood sample detection system |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN101052469A (en) * | 2004-09-02 | 2007-10-10 | 霍尼韦尔国际公司 | Method and apparatus for determining one or more operating parameters for a microfluidic circuit |
| CN201744003U (en) * | 2010-07-14 | 2011-02-16 | 汪贤宗 | Transfusion device with function of automatic air discharge |
| CN102958549A (en) * | 2010-06-28 | 2013-03-06 | 霍夫曼-拉罗奇有限公司 | Sensor for use in liquid medicament delivery systems |
| CN105527415A (en) * | 2016-01-17 | 2016-04-27 | 韩照网 | Fast detection device and method for blood physical signs |
| CN207689255U (en) * | 2017-12-29 | 2018-08-03 | 武汉明德生物科技股份有限公司 | Biochemical test card |
| CN109536374A (en) * | 2018-11-27 | 2019-03-29 | 南京先进激光技术研究院 | It is a kind of with avoid bubble generate structure reagent reaction tube |
-
2019
- 2019-12-13 CN CN201911283082.4A patent/CN110927085A/en active Pending
Patent Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101052469A (en) * | 2004-09-02 | 2007-10-10 | 霍尼韦尔国际公司 | Method and apparatus for determining one or more operating parameters for a microfluidic circuit |
| CN102958549A (en) * | 2010-06-28 | 2013-03-06 | 霍夫曼-拉罗奇有限公司 | Sensor for use in liquid medicament delivery systems |
| CN201744003U (en) * | 2010-07-14 | 2011-02-16 | 汪贤宗 | Transfusion device with function of automatic air discharge |
| CN105527415A (en) * | 2016-01-17 | 2016-04-27 | 韩照网 | Fast detection device and method for blood physical signs |
| CN207689255U (en) * | 2017-12-29 | 2018-08-03 | 武汉明德生物科技股份有限公司 | Biochemical test card |
| CN109536374A (en) * | 2018-11-27 | 2019-03-29 | 南京先进激光技术研究院 | It is a kind of with avoid bubble generate structure reagent reaction tube |
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