CN110917921A - Automatic pharmacy powder blending system based on biological detection and working method thereof - Google Patents
Automatic pharmacy powder blending system based on biological detection and working method thereof Download PDFInfo
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- CN110917921A CN110917921A CN201911008358.8A CN201911008358A CN110917921A CN 110917921 A CN110917921 A CN 110917921A CN 201911008358 A CN201911008358 A CN 201911008358A CN 110917921 A CN110917921 A CN 110917921A
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
- B01F27/00—Mixers with rotary stirring devices in fixed receptacles; Kneaders
- B01F27/80—Mixers with rotary stirring devices in fixed receptacles; Kneaders with stirrers rotating about a substantially vertical axis
- B01F27/90—Mixers with rotary stirring devices in fixed receptacles; Kneaders with stirrers rotating about a substantially vertical axis with paddles or arms
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
- B01F27/00—Mixers with rotary stirring devices in fixed receptacles; Kneaders
- B01F27/05—Stirrers
- B01F27/11—Stirrers characterised by the configuration of the stirrers
- B01F27/112—Stirrers characterised by the configuration of the stirrers with arms, paddles, vanes or blades
- B01F27/1125—Stirrers characterised by the configuration of the stirrers with arms, paddles, vanes or blades with vanes or blades extending parallel or oblique to the stirrer axis
- B01F27/11251—Stirrers characterised by the configuration of the stirrers with arms, paddles, vanes or blades with vanes or blades extending parallel or oblique to the stirrer axis having holes in the surface
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
- B01F27/00—Mixers with rotary stirring devices in fixed receptacles; Kneaders
- B01F27/60—Mixers with rotary stirring devices in fixed receptacles; Kneaders with stirrers rotating about a horizontal or inclined axis
- B01F27/70—Mixers with rotary stirring devices in fixed receptacles; Kneaders with stirrers rotating about a horizontal or inclined axis with paddles, blades or arms
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
- B01F33/00—Other mixers; Mixing plants; Combinations of mixers
- B01F33/80—Mixing plants; Combinations of mixers
- B01F33/83—Mixing plants specially adapted for mixing in combination with disintegrating operations
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
- B01F33/00—Other mixers; Mixing plants; Combinations of mixers
- B01F33/80—Mixing plants; Combinations of mixers
- B01F33/836—Mixing plants; Combinations of mixers combining mixing with other treatments
- B01F33/8361—Mixing plants; Combinations of mixers combining mixing with other treatments with disintegrating
- B01F33/83612—Mixing plants; Combinations of mixers combining mixing with other treatments with disintegrating by crushing or breaking
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
- B01F35/00—Accessories for mixers; Auxiliary operations or auxiliary devices; Parts or details of general application
- B01F35/181—Preventing generation of dust or dirt; Sieves; Filters
- B01F35/187—Preventing generation of dust or dirt; Sieves; Filters using filters in mixers, e.g. during venting
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
- B01F35/00—Accessories for mixers; Auxiliary operations or auxiliary devices; Parts or details of general application
- B01F35/20—Measuring; Control or regulation
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
- B01F35/00—Accessories for mixers; Auxiliary operations or auxiliary devices; Parts or details of general application
- B01F35/71—Feed mechanisms
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- Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Apparatus Associated With Microorganisms And Enzymes (AREA)
- Mixers Of The Rotary Stirring Type (AREA)
Abstract
The invention relates to a biological detection-based automatic pharmaceutical powder blending system and a working method thereof, wherein the system comprises a mixing bin and further comprises: a processor; the mixing bin comprises a first-stage feeding hole at the top and a first-stage discharging hole at the bottom, and a plurality of feeding grooves are formed in the first-stage feeding hole; the bottom end of the feed chute is provided with a sliding piece which moves along the sliding chute; the top of the feed chute is provided with a secondary feed inlet, and the bottom of the feed chute is provided with a secondary discharge outlet; the second-stage discharge hole is provided with a second-stage electric bin gate, and the first-stage feed hole is provided with a first-stage electric bin gate; a mixing chamber is arranged in the mixing bin, and a stirring device is arranged in the mixing chamber; the biological monitoring device is arranged at the tail end of the stirring device and outputs the monitored microorganism content to the processor; the tail end of the stirring device is also provided with a current monitoring device, and the current monitoring device outputs a current value to the processor; a micro-current generating device is arranged in the mixing chamber and outputs micro-current to the mixture in the mixing chamber.
Description
Technical Field
The invention relates to the field of biological pharmacy, in particular to a biological detection-based automatic pharmacy distribution and neutralization system and a working method thereof.
Background
Biopharmaceuticals refer to the study of organisms, biological tissues, cells, organs, body fluids, etc., using microbiological, biological, medical, biochemical, etc., results. The product is prepared by comprehensively utilizing the principles and methods of microbiology, chemistry, biochemistry, biotechnology, pharmacy and the like, and is used for prevention, treatment and diagnosis.
The biological pharmaceutical raw materials mainly comprise natural biological materials, including microorganisms, human bodies, animals, plants, marine organisms and the like. With the development of biotechnology, purposely artificially prepared biological raw materials become the main source of the current biopharmaceutical raw materials. Such as animal material prepared by immunization, microorganism or other cell material prepared by changing gene structure, etc. The biological medicine has the features of high pharmacological activity, less toxic side effect and high nutritive value. The biological medicine mainly comprises protein, nucleic acid, saccharide, lipid, etc. The constituent units of the substances are amino acid, nucleotide, monosaccharide, fatty acid and the like, and the substances are not only harmless to human bodies but also important nutrient substances.
Need use mixing arrangement among the bio-pharmaceuticals process, mixing arrangement is used for mixing powder, and current mixing arrangement simply is used for mixing and can not monitor the powder state of mixing in-process, and especially the state monitoring means to the microorganism is single.
Disclosure of Invention
The purpose of the invention is as follows:
aiming at the problems mentioned in the background technology, the invention provides a biological detection-based pharmaceutical distribution automatic equalization system and a working method thereof.
The technical scheme is as follows:
the utility model provides an automatic system that all neutralizes of pharmacy powder based on biological detection, includes and mixes the storehouse, still includes: a processor;
the mixing bin comprises a first-stage feeding hole at the top and a first-stage discharging hole at the bottom, and a plurality of feeding grooves are formed in the first-stage feeding hole; the bottom end of the feeding groove is provided with a sliding piece, and the sliding piece moves along the sliding groove; the top of the feed chute is provided with a secondary feed inlet, and the bottom of the feed chute is provided with a secondary discharge outlet; the second-stage discharge hole is provided with a second-stage electric bin gate, and the first-stage feed hole is provided with a first-stage electric bin gate;
powder is stored in the feeding grooves, and different powder is stored in different feeding grooves; the sliding part is connected with the processor, the processor outputs a moving instruction to the sliding part according to the instruction, and the sliding part moves the specified feeding groove to the position right above the first-stage feeding hole according to the moving instruction; after the designated feeding groove is in place, the sliding part feeds back an in-place signal to the processor, and the processor outputs an opening signal to the first-stage electric bin gate and the corresponding second-stage electric bin gate after acquiring the in-place signal;
a mixing chamber is arranged in the mixing bin, a stirring device is arranged in the mixing chamber, the stirring device is connected with the processor, the processor outputs an opening signal or a closing signal to the stirring device, and the stirring device starts stirring or stops stirring according to the opening signal or the closing signal;
a biological monitoring device is arranged at the tail end of the stirring device and used for detecting the content of microorganisms in the mixture, and the biological monitoring device outputs the monitored content of the microorganisms to the processor;
the tail end of the stirring device is also provided with a current monitoring device, the current monitoring device is used for monitoring the magnitude of micro-current in the mixture, and the current monitoring device outputs a current value to the processor;
and a micro-current generating device is arranged in the mixing chamber and outputs micro-current to the mixture in the mixing chamber.
As a preferred mode of the invention, a temperature control device is arranged between the inner wall of the mixing bin and the outer wall of the mixing chamber, the temperature control device is provided with a plurality of heating wires, and the heating wires are arranged around the outer wall of the mixing chamber;
the temperature control device is connected with the processor, the processor outputs control temperature to the temperature control device, and the temperature control device adjusts the temperature according to the control temperature.
As a preferable mode of the invention, a heat insulation layer is filled between the inner wall of the mixing bin and the outer wall of the mixing chamber, and the heat insulation layer is made of a heat insulation material and is used for heat insulation of the mixing chamber.
As a preferable mode of the invention, the stirring device comprises a stirring shaft and a plurality of stirring paddles, wherein the stirring paddles are respectively arranged around the stirring shaft; after the stirring device is started, the stirring shaft rotates, and the stirring paddle moves along with the stirring shaft;
the stirring paddle is provided with a stirring plane, a through hole penetrating through the rotating plane is formed in the stirring plane, and a rotating device is arranged in the through hole; the rotating device is connected with the processor, and the processor outputs an opening signal or a closing signal to the stirring device and simultaneously synchronously outputs the opening signal or the closing signal to the rotating device.
As a preferable mode of the present invention, the filter screens are disposed on both sides of the through holes, and the filter screens cover the corresponding through holes.
As a preferable mode of the present invention, the present invention further comprises an agitation assisting device, wherein the agitation assisting device comprises a mixer disposed at the bottom of the mixing chamber and a filtering device disposed on the inner wall of the mixing chamber;
the mixer is linked with the stirring device, the mixer is started after the stirring device is started, and the mixer is stopped after the stirring device is stopped;
the filter device is provided with a plurality of filter devices which are uniformly distributed on the inner wall of the mixing bin, and the plane of the screen is vertical to the inner wall of the mixing bin.
As a preferred mode of the invention, a vibration device is arranged at the bottom of the filtering device, the vibration device is connected with the processor, and the vibration device is used for vibrating the filtering device; the processor outputs a starting signal to the vibration device, and the vibration device starts vibration.
The method comprises the following steps:
the processor outputs a starting signal to the stirring device, and the stirring device stirs the mixture in the mixing bin;
the processor outputs a moving instruction to the sliding piece, the sliding piece moves to a specified position according to the moving instruction, and the sliding piece feeds back a position signal to the processor;
the processor acquires the in-place signal, and outputs an opening signal to the first-stage electric bin gate and the corresponding second-stage electric bin gate after acquiring the in-place signal;
and after the powder feeding is finished, the processor outputs closing signals to the first-stage electric bin gate and the corresponding second-stage electric bin gate.
The method comprises the following steps:
the biological monitoring device monitors the content of microorganisms in the mixing bin and outputs the monitored content of the microorganisms to the processor;
the processor compares the real-time microorganism content according to a preset microorganism content threshold value;
if the real-time microorganism content exceeds a preset microorganism content threshold value, the processor outputs a closing signal to the stirring device;
or, the current monitoring device monitors the magnitude of micro-current in the mixture and outputs the current value to the processor;
and the processor compares the preset current value threshold with the real-time current value, and if the preset current value threshold is not consistent with the real-time current value threshold, the processor outputs a closing signal to the stirring device.
The method comprises the following steps:
when the processor outputs a starting signal to the stirring device, the processor also outputs a starting signal to the rotating device;
when the processor outputs a closing signal to the stirring device, the processor also outputs a closing signal to the rotating device.
The invention realizes the following beneficial effects:
automatic feeding is realized through the cooperation of the sliding piece and the sliding groove. The release of micro-current to the mixture determines the mixing state of the powder by monitoring the conductive state of the mixture. The sanitary state of the mixture is judged according to the microbial content of the mixture, and the monitoring of the state of the mixture in the mixed state is improved. Improve agitating unit's stirring efficiency through rotary device, the filter screen sieves the powder, avoids the caking of stirring in-process. The vibrating device is used for vibrating and removing the mixture attached to the screen and eliminating the caking in the mixture.
Drawings
The accompanying drawings, which are incorporated in and constitute a part of this specification, illustrate embodiments consistent with the present disclosure and together with the description, serve to explain the principles of the disclosure.
FIG. 1 is a schematic diagram of an automatic pharmaceutical powder blending system based on biological detection according to the present invention;
FIG. 2 is a schematic diagram of the interior of a mixing bin of the biological detection-based pharmaceutical powder automatic blending system provided by the invention;
FIG. 3 is a schematic diagram of a mixing bin of a second biological detection-based pharmaceutical powder automatic blending system according to the present invention;
FIG. 4 is a schematic view of a stirring paddle of the biological detection-based pharmaceutical powder automatic blending system provided by the invention;
fig. 5 is a schematic diagram of a mixing bin of a third biological detection-based pharmaceutical powder automatic blending system provided by the invention.
Wherein: 1. the device comprises a mixing bin, 11 parts of a mixing chamber, 2 parts of a feeding groove, 3 parts of a sliding groove, 4 parts of a sliding part, 5 parts of a stirring device, 51 parts of a stirring shaft, 52 parts of a stirring paddle, 53 parts of a stirring plane, 54 parts of a through hole, 55 parts of a rotating device, 56 parts of a filter screen, 6 parts of a current monitoring device, 7 parts of an insulating layer, 81 parts of a mixer, 82 parts of a filtering device and 9 parts of a vibrating device.
Detailed Description
The technical solutions in the embodiments of the present invention will be clearly and completely described below with reference to the drawings in the embodiments of the present invention, and it is obvious that the described embodiments are only a part of the embodiments of the present invention, and not all of the embodiments.
Example one
Reference is made to fig. 1-2 for example.
The utility model provides an automatic system that all neutralizes of pharmacy powder based on biological detection, includes and mixes storehouse 1, still includes: a processor.
The sliding chute 3 is a track, the plurality of feeding chutes 2 are sequentially arranged on the sliding chute 3, the sliding parts 4 of the feeding chutes 2 are embedded in the sliding chute 3, and the sliding parts 4 slide along the sliding chute 3. The slide member 4 slides to drive the feed chute 2 to move along the slide chute 3.
The top of feed chute 2 is provided with the second grade feed inlet, the bottom of feed chute 2 is provided with the second grade discharge gate. The second grade discharge gate sets up the electronic door in second grade, the one-level feed inlet is provided with the electronic door in one-level. The corresponding second-stage electric bin gate and the first-stage electric bin gate are opened simultaneously, and the powder in the corresponding feeding groove 2 is released into the mixing bin 1.
Powder is stored in the feeding grooves 2, and different powder is stored in different feeding grooves 2. The sliding part 4 is connected with the processor, the processor outputs a moving instruction to the sliding part 4 according to the instruction, and the sliding part 4 moves the appointed feeding groove 2 to the position right above the first-stage feeding hole according to the moving instruction. After the designated feeding groove 2 is in place, the sliding part 4 feeds back an in-place signal to the processor, and the processor outputs an opening signal to the first-stage electric bin gate and the corresponding second-stage electric bin gate after acquiring the in-place signal.
The processor is stored with the information of the feed chute 2, including the information of the powder stored with the number of the feed chute 2 and corresponding to the feed chute 2. If the powder processor in the corresponding feeding groove 2 needs to be released to output a moving signal to the sliding part 4, wherein the moving signal comprises the information of the appointed feeding groove 2, and the sliding part 4 moves the appointed feeding groove 2 to the first-stage feeding hole according to the moving signal.
A mixing chamber 11 is arranged in the mixing bin 1, a stirring device 5 is arranged in the mixing chamber 11, the stirring device 5 is connected with the processor, the processor outputs an opening signal or a closing signal to the stirring device 5, and the stirring device 5 starts stirring or stops stirring according to the opening signal or the closing signal.
The stirring device 5 is used for mixing the powder in the mixing chamber 11, and the processor controls the stirring of the mixture by the stirring device 5. The powder released from the feed chute 2 to the mixing bin 1 enters the mixing chamber 11 for mixing.
The end of the stirring device 5 is provided with a biological monitoring device, the biological monitoring device is used for detecting the content of microorganisms in the mixture, and the biological monitoring device outputs the monitored content of the microorganisms to the processor.
The biological monitoring device is used to monitor the metabolic products of the microorganisms and thus the content of the microorganisms, for example, to monitor the amount of carbon dioxide in the mixing chamber 11 and thus to determine the amount of the microorganisms. If the content of the microorganisms exceeds the standard in the aseptic operation, the mixture is not qualified, and if the microorganisms are the target objects, the amount of the microorganisms is not qualified, the mixture is not qualified.
The end of the stirring device 5 is also provided with a current monitoring device 6, the current monitoring device 6 is used for monitoring the magnitude of micro-current in the mixture, and the current monitoring device 6 outputs a current value to the processor.
The current monitoring device 6 is used for monitoring the current conducted by the mixture and acquiring the state change of the mixture through the conversion of the conductivity. The electric conductivity of the powder is different under different powder mixing states, and the mixing state of the mixture is judged by monitoring the electric conductivity.
A micro-current generating device is arranged in the mixing chamber 11 and outputs micro-current to the mixture in the mixing chamber 11. The micro-current generating device releases micro-current to the mixture, and the inner wall of the mixing chamber 11 and the devices in the mixing bin 1 are made of non-conducting materials, so that the influence of the micro-current on equipment is avoided.
The processor outputs an opening signal to the stirring device 5, and the stirring device 5 stirs the mixture in the mixing bin 1.
The processor outputs a movement instruction to the sliding part 4, the sliding part 4 moves to a specified position according to the movement instruction, and the sliding part 4 feeds back a position signal to the processor.
The processor acquires the in-place signal, and the processor outputs an opening signal to the first-stage electric bin gate and the corresponding second-stage electric bin gate after acquiring the in-place signal.
And after the powder feeding is finished, the processor outputs closing signals to the first-stage electric bin gate and the corresponding second-stage electric bin gate.
The biological monitoring device monitors the microorganism content in the mixing bin 1 and outputs the monitored microorganism content to the processor.
The processor compares the real-time microbial content according to a preset microbial content threshold.
If the real-time microbial content exceeds the preset microbial content threshold, the processor outputs a closing signal to the stirring device 5.
The preset microbial content threshold is determined according to the setting of a user, and the preset microbial content threshold is different according to different powder materials. The microbial content threshold values of different mixing stages can be determined according to the properties of the added powder.
Alternatively, the current monitoring device 6 monitors the magnitude of the micro-current in the mixture and outputs the current value to the processor.
The processor compares the preset current value threshold with the real-time current value, and if the current value threshold is not consistent with the real-time current value threshold, the processor outputs a closing signal to the stirring device 5.
The preset current value threshold is determined according to the setting of a user, and the preset current value threshold is different according to different powder materials. The current value threshold values of different mixing stages can be determined according to the properties of the added powder.
Example two
Reference is made to fig. 3 as an example.
The present embodiment is substantially the same as the first embodiment described above, except that, as a preferred mode of the present embodiment, a temperature control device is disposed between the inner wall of the mixing bin 1 and the outer wall of the mixing chamber 11, and the temperature control device is a plurality of heating wires disposed around the outer wall of the mixing chamber 11.
The temperature control device is connected with the processor, the processor outputs control temperature to the temperature control device, and the temperature control device adjusts the temperature according to the control temperature.
The processor adjusts the temperature of the temperature control device according to different powder mixing stages.
As a preferable mode of this embodiment, an insulating layer 7 is filled between the inner wall of the mixing bin 1 and the outer wall of the mixing chamber 11, and the insulating layer 7 is made of an insulating material, and the insulating layer 7 is used for insulating the mixing chamber 11. The heat-insulating layer 7 is filled with heat-insulating materials, so that the heat-insulating capability is improved, the temperature control is facilitated,
EXAMPLE III
Reference is made to fig. 4-5 for example.
The present embodiment is substantially the same as the first embodiment, except that, as a preferable mode of the present embodiment, the stirring device 5 includes a stirring shaft 51 and stirring paddles 52, and a plurality of the stirring paddles 52 are respectively disposed around the stirring shaft 51. After the stirring device 5 is started, the stirring shaft 51 rotates, and the stirring paddle 52 moves along with the stirring shaft 51.
The stirring paddle 52 is provided with a stirring plane 53, a through hole 54 penetrating through the rotating plane is formed in the stirring plane 53, and a rotating device 55 is arranged in the through hole 54. The rotating device 55 is connected to the processor, and the processor outputs an on signal or an off signal to the stirring device 5 and simultaneously outputs an on signal or an off signal to the rotating device 55.
A plurality of stirring paddles 52 encircle (mixing) shaft 51 and set up, are provided with rotary device 55 on stirring plane 53 of stirring paddle 52, and rotary device 55 is used for supplementary agitating unit 5 stirring after opening to can smash the caking in the mixture, and carry out more abundant stirring to the mixture.
As a preferable mode of the present embodiment, a filter screen 56 is disposed on both sides of the through hole 54, and the filter screen 56 covers the corresponding through hole 54. The screen 56 screens the mixture.
As a preferable mode of the present embodiment, the mixing device further includes a mixing auxiliary device, and the mixing auxiliary device includes a mixer 81 disposed at the bottom of the mixing bin 1 and a filtering device 82 disposed on the inner wall of the mixing bin 1.
The mixer 81 is a device for mixing at the bottom of the mixing chamber 1, and may be an electric stirrer.
The blender 81 and the stirring device 5 are linked, after the stirring device 5 is started, the blender 81 is started, and after the stirring device 5 is stopped, the blender 81 is stopped.
The filtering devices 82 are provided with a plurality of filtering devices 82, the filtering devices 82 are uniformly distributed on the inner wall of the mixing bin 1, and the plane of the screen is vertical to the inner wall of the mixing bin 1. The filtering devices 82 are distributed along the inner wall of the mixing bin 1, and the filtering devices 82 are used for sieving the mixture and separating the mixture terminal agglomerates.
As a preferable mode of this embodiment, a vibration device 9 is disposed at the bottom of the filtering device 82, the vibration device 9 is connected to the processor, and the vibration device 9 is used for vibrating the filtering device 82. The processor outputs an opening signal to the vibration device 9, and the vibration device 9 starts vibration.
The vibration means 9 is used to crush the agglomerates, and to transmit vibration to the agglomerates to crush the agglomerates, and the vibration means 9 is also used to reduce the adhered mixture on the filtering means 82 by vibration after the mixture is released.
Example four
The present embodiment is substantially the same as the first embodiment, except that, as a preferred mode of the present embodiment, the following steps are included:
the processor outputs an opening signal to the stirring device 5, and the stirring device 5 stirs the mixture in the mixing bin 1.
The processor outputs a movement instruction to the sliding part 4, the sliding part 4 moves to a specified position according to the movement instruction, and the sliding part 4 feeds back a position signal to the processor.
The processor acquires the in-place signal, and the processor outputs an opening signal to the first-stage electric bin gate and the corresponding second-stage electric bin gate after acquiring the in-place signal.
And after the powder feeding is finished, the processor outputs closing signals to the first-stage electric bin gate and the corresponding second-stage electric bin gate.
As a preferable mode of the present embodiment, the method includes the steps of:
the biological monitoring device monitors the microorganism content in the mixing bin 1 and outputs the monitored microorganism content to the processor.
The processor compares the real-time microbial content according to a preset microbial content threshold.
If the real-time microbial content exceeds the preset microbial content threshold, the processor outputs a closing signal to the stirring device 5.
Alternatively, the current monitoring device 6 monitors the magnitude of the micro-current in the mixture and outputs the current value to the processor.
The processor compares the preset current value threshold with the real-time current value, and if the current value threshold is not consistent with the real-time current value threshold, the processor outputs a closing signal to the stirring device 5.
As a preferable mode of the present embodiment, the method includes the steps of:
when the processor outputs an on signal to the stirring device 5, the processor also outputs an on signal to the rotating device 55.
When the processor outputs a shutdown signal to the stirring device 5, the processor also outputs a shutdown signal to the rotating device 55.
The above embodiments are merely illustrative of the technical ideas and features of the present invention, and are intended to enable those skilled in the art to understand the contents of the present invention and implement the present invention, and not to limit the scope of the present invention. All equivalent changes or modifications made according to the spirit of the present invention should be covered within the protection scope of the present invention.
Claims (10)
1. The utility model provides an automatic system that all neutralizes of pharmacy powder based on biological detection, includes mixed storehouse (1), its characterized in that still includes: a processor;
the mixing bin (1) comprises a first-stage feeding hole at the top and a first-stage discharging hole at the bottom, and a plurality of feeding grooves (2) are formed in the first-stage feeding hole; the bottom end of the feeding groove (2) is provided with a sliding piece (4), and the sliding piece (4) moves along the sliding groove (3); a secondary feed inlet is formed in the top of the feed tank (2), and a secondary discharge outlet is formed in the bottom of the feed tank (2); the second-stage discharge hole is provided with a second-stage electric bin gate, and the first-stage feed hole is provided with a first-stage electric bin gate;
powder is stored in the feeding grooves (2), and different powder is stored in different feeding grooves (2); the sliding part (4) is connected with the processor, the processor outputs a moving instruction to the sliding part (4) according to the instruction, and the sliding part (4) moves the specified feeding groove (2) to the position right above the first-stage feeding hole according to the moving instruction; after the designated feeding groove (2) is in place, the sliding part (4) feeds back an in-place signal to the processor, and the processor outputs an opening signal to the first-stage electric bin gate and the corresponding second-stage electric bin gate after acquiring the in-place signal;
a mixing chamber (11) is arranged in the mixing bin (1), a stirring device (5) is arranged in the mixing chamber (11), the stirring device (5) is connected with the processor, the processor outputs an opening signal or a closing signal to the stirring device (5), and the stirring device (5) starts stirring or stops stirring according to the opening signal or the closing signal;
a biological monitoring device is arranged at the tail end of the stirring device (5) and used for detecting the content of microorganisms in the mixture, and the biological monitoring device outputs the monitored content of the microorganisms to the processor;
the tail end of the stirring device (5) is also provided with a current monitoring device (6), the current monitoring device (6) is used for monitoring the magnitude of micro-current in the mixture, and the current monitoring device (6) outputs a current value to the processor;
a micro-current generating device is arranged in the mixing chamber (11), and the micro-current generating device outputs micro-current to the mixture in the mixing chamber (11).
2. The system for automatically homogenizing pharmaceutical powder based on biological detection according to claim 1, wherein a temperature control device is arranged between the inner wall of the mixing bin (1) and the outer wall of the mixing chamber (11), and the temperature control device is a plurality of heating wires which are arranged around the outer wall of the mixing chamber (11);
the temperature control device is connected with the processor, the processor outputs control temperature to the temperature control device, and the temperature control device adjusts the temperature according to the control temperature.
3. The automatic pharmaceutical powder blending system based on biological detection as claimed in claim 2, wherein an insulating layer (7) is filled between the inner wall of the mixing bin (1) and the outer wall of the mixing chamber (11), the insulating layer (7) is made of an insulating material, and the insulating layer (7) is used for insulating the mixing chamber (11).
4. The system for automatically homogenizing pharmaceutical powder based on biological detection according to claim 1, wherein the stirring device (5) comprises a stirring shaft (51) and stirring paddles (52), and a plurality of stirring paddles (52) are respectively arranged around the stirring shaft (51); after the stirring device (5) is started, the stirring shaft (51) rotates, and the stirring paddle (52) moves along with the stirring shaft (51);
the stirring paddle (52) is provided with a stirring plane (53), a through hole (54) penetrating through the rotating plane is formed in the stirring plane (53), and a rotating device (55) is arranged in the through hole (54); the rotating device (55) is connected with the processor, and the processor outputs an opening signal or a closing signal to the stirring device (5) and simultaneously outputs the opening signal or the closing signal to the rotating device (55).
5. Pharmaceutical powder automatic blending system based on biological detection, according to claim 4, characterized in that both sides of said through holes (54) are provided with a screen (56), said screen (56) covering the corresponding through hole (54).
6. The system for automatically homogenizing pharmaceutical powder based on biological detection according to claim 1, characterized by further comprising an agitation assisting device, wherein the agitation assisting device comprises a mixer (81) arranged at the bottom of the mixing bin (1) and a filtering device (82) arranged on the inner wall of the mixing bin (1);
the mixer (81) is linked with the stirring device (5), the mixer (81) is started after the stirring device (5) is started, and the mixer (81) is stopped after the stirring device (5) is stopped;
the filter device (82) is provided with a plurality of filter devices (82), the filter devices (82) are uniformly distributed on the inner wall of the mixing bin (1), and the plane of the screen mesh is perpendicular to the inner wall of the mixing bin (1).
7. The system for automatically homogenizing pharmaceutical powder based on biological detection as claimed in claim 6, characterized in that a vibration device (9) is arranged at the bottom of the filtering device (82), the vibration device (9) is connected with the processor, the vibration device (9) is used for vibrating the filtering device (82); the processor outputs an opening signal to the vibration device (9), and the vibration device (9) opens vibration.
8. The working method of the automatic pharmaceutical powder lot neutralization system based on biological detection according to any one of claims 1-7, characterized by comprising the following steps:
the processor outputs a starting signal to the stirring device (5), and the stirring device (5) stirs the mixture in the mixing bin (1);
the processor outputs a moving instruction to the sliding piece (4), the sliding piece (4) moves to a specified position according to the moving instruction, and the sliding piece (4) feeds back a position signal to the processor;
the processor acquires the in-place signal, and outputs an opening signal to the first-stage electric bin gate and the corresponding second-stage electric bin gate after acquiring the in-place signal;
and after the powder feeding is finished, the processor outputs closing signals to the first-stage electric bin gate and the corresponding second-stage electric bin gate.
9. The working method of the automatic pharmaceutical powder lot neutralization system based on biological detection as claimed in claim 8, characterized by comprising the following steps:
the biological monitoring device monitors the microorganism content in the mixing bin (1) and outputs the monitored microorganism content to the processor;
the processor compares the real-time microorganism content according to a preset microorganism content threshold value;
if the real-time microorganism content exceeds a preset microorganism content threshold value, the processor outputs a closing signal to the stirring device (5);
or the current monitoring device (6) monitors the magnitude of micro-current in the mixture and outputs the current value to the processor;
the processor compares the preset current value threshold with the real-time current value, and if the current value threshold is not consistent with the real-time current value threshold, the processor outputs a closing signal to the stirring device (5).
10. The working method of the automatic pharmaceutical powder lot neutralization system based on biological detection as claimed in claim 9, characterized by comprising the following steps:
when the processor outputs a starting signal to the stirring device (5), the processor also outputs a starting signal to the rotating device (55);
when the processor outputs a closing signal to the stirring device (5), the processor also outputs a closing signal to the rotating device (55).
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| CN201911008358.8A CN110917921A (en) | 2019-10-22 | 2019-10-22 | Automatic pharmacy powder blending system based on biological detection and working method thereof |
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| CN201911008358.8A CN110917921A (en) | 2019-10-22 | 2019-10-22 | Automatic pharmacy powder blending system based on biological detection and working method thereof |
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