CN110917402A - Multifunctional artificial dura mater - Google Patents
Multifunctional artificial dura mater Download PDFInfo
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- CN110917402A CN110917402A CN201911203247.2A CN201911203247A CN110917402A CN 110917402 A CN110917402 A CN 110917402A CN 201911203247 A CN201911203247 A CN 201911203247A CN 110917402 A CN110917402 A CN 110917402A
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- 210000001951 dura mater Anatomy 0.000 title claims abstract description 19
- 239000003814 drug Substances 0.000 claims abstract description 35
- BQCADISMDOOEFD-UHFFFAOYSA-N Silver Chemical compound [Ag] BQCADISMDOOEFD-UHFFFAOYSA-N 0.000 claims abstract description 34
- 102000015336 Nerve Growth Factor Human genes 0.000 claims abstract description 24
- 108010025020 Nerve Growth Factor Proteins 0.000 claims abstract description 24
- 229940053128 nerve growth factor Drugs 0.000 claims abstract description 24
- 230000002439 hemostatic effect Effects 0.000 claims abstract description 19
- 239000000463 material Substances 0.000 claims abstract description 19
- 239000012528 membrane Substances 0.000 claims abstract description 8
- 229940079593 drug Drugs 0.000 claims description 3
- 239000004627 regenerated cellulose Substances 0.000 claims description 2
- 238000005507 spraying Methods 0.000 claims description 2
- 230000000694 effects Effects 0.000 abstract description 15
- 230000001737 promoting effect Effects 0.000 abstract description 8
- 230000006870 function Effects 0.000 abstract description 6
- 230000029663 wound healing Effects 0.000 abstract description 6
- 206010059866 Drug resistance Diseases 0.000 abstract description 4
- 206010052428 Wound Diseases 0.000 abstract description 4
- 208000027418 Wounds and injury Diseases 0.000 abstract description 4
- 230000000844 anti-bacterial effect Effects 0.000 abstract description 4
- 230000000740 bleeding effect Effects 0.000 abstract description 4
- 210000005013 brain tissue Anatomy 0.000 abstract description 4
- 230000003213 activating effect Effects 0.000 abstract description 3
- 230000010261 cell growth Effects 0.000 abstract description 3
- 230000035699 permeability Effects 0.000 abstract description 3
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 abstract description 3
- 230000001954 sterilising effect Effects 0.000 abstract description 2
- 238000004659 sterilization and disinfection Methods 0.000 abstract description 2
- 210000004027 cell Anatomy 0.000 description 6
- 229910052709 silver Inorganic materials 0.000 description 5
- 239000004332 silver Substances 0.000 description 5
- 230000002490 cerebral effect Effects 0.000 description 3
- 210000004292 cytoskeleton Anatomy 0.000 description 3
- 238000005516 engineering process Methods 0.000 description 2
- 230000012010 growth Effects 0.000 description 2
- 210000001519 tissue Anatomy 0.000 description 2
- 241000606153 Chlamydia trachomatis Species 0.000 description 1
- 241000588724 Escherichia coli Species 0.000 description 1
- 241000588653 Neisseria Species 0.000 description 1
- 230000004075 alteration Effects 0.000 description 1
- 229940030225 antihemorrhagics Drugs 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 230000008827 biological function Effects 0.000 description 1
- 210000001175 cerebrospinal fluid Anatomy 0.000 description 1
- 229940038705 chlamydia trachomatis Drugs 0.000 description 1
- 230000018109 developmental process Effects 0.000 description 1
- 230000004069 differentiation Effects 0.000 description 1
- 230000014509 gene expression Effects 0.000 description 1
- 239000002874 hemostatic agent Substances 0.000 description 1
- 230000002401 inhibitory effect Effects 0.000 description 1
- 208000014674 injury Diseases 0.000 description 1
- 230000002147 killing effect Effects 0.000 description 1
- 229910052751 metal Inorganic materials 0.000 description 1
- 239000002184 metal Substances 0.000 description 1
- 238000000034 method Methods 0.000 description 1
- 244000000010 microbial pathogen Species 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000005709 nerve cell growth Effects 0.000 description 1
- 210000002241 neurite Anatomy 0.000 description 1
- 210000002569 neuron Anatomy 0.000 description 1
- 230000035764 nutrition Effects 0.000 description 1
- 235000016709 nutrition Nutrition 0.000 description 1
- 239000002245 particle Substances 0.000 description 1
- 210000002856 peripheral neuron Anatomy 0.000 description 1
- 230000008569 process Effects 0.000 description 1
- 230000008929 regeneration Effects 0.000 description 1
- 238000011069 regeneration method Methods 0.000 description 1
- 230000001105 regulatory effect Effects 0.000 description 1
- 230000008439 repair process Effects 0.000 description 1
- 230000002940 repellent Effects 0.000 description 1
- 239000005871 repellent Substances 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 238000006467 substitution reaction Methods 0.000 description 1
- 230000008733 trauma Effects 0.000 description 1
- 238000004078 waterproofing Methods 0.000 description 1
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- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
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- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/02—Inorganic materials
- A61L27/04—Metals or alloys
- A61L27/047—Other specific metals or alloys not covered by A61L27/042 - A61L27/045 or A61L27/06
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- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
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- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
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- A—HUMAN NECESSITIES
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- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
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- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
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- A61L2300/10—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing inorganic materials
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- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
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- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
- A61L2300/412—Tissue-regenerating or healing or proliferative agents
- A61L2300/414—Growth factors
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- A—HUMAN NECESSITIES
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- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
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- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
- A61L2300/424—Anti-adhesion agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/60—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a special physical form
- A61L2300/606—Coatings
- A61L2300/608—Coatings having two or more layers
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- A—HUMAN NECESSITIES
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- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2430/00—Materials or treatment for tissue regeneration
- A61L2430/32—Materials or treatment for tissue regeneration for nerve reconstruction
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Transplantation (AREA)
- Oral & Maxillofacial Surgery (AREA)
- Medicinal Chemistry (AREA)
- Dermatology (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Heart & Thoracic Surgery (AREA)
- Molecular Biology (AREA)
- Cardiology (AREA)
- Vascular Medicine (AREA)
- Anesthesiology (AREA)
- Hematology (AREA)
- Inorganic Chemistry (AREA)
- Materials For Medical Uses (AREA)
Abstract
The invention discloses a multifunctional artificial dura mater, which comprises a membrane, wherein the membrane is prepared from a cell scaffold layer, a waterproof material layer, a nano-silver dressing, a nerve growth factor layer, an anti-adhesion medicament and a hemostatic medicament, wherein the waterproof material layer has a good waterproof effect, the nano-silver dressing has the effects of strong sterilization effect, no drug resistance, strong permeability and long antibacterial action time, and has the effects of promoting self circulation of tissues around wounds, activating and promoting cell growth and wound healing by combining with the nerve growth factor layer, the anti-adhesion layer has the effect of preventing adhesion with brain tissues, the hemostatic medicament has the hemostatic effect, and various structures are matched with each other, so that the artificial dura mater has various functions of stopping bleeding, promoting wound healing, preventing water and the like.
Description
Technical Field
The invention belongs to the technical field of artificial dura mater, and particularly relates to a multifunctional artificial dura mater.
Background
The cerebral dura mater layer is arranged outside the brain tissue of a human body and has the functions of protecting the brain tissue, preventing cerebrospinal fluid from exosmosis, preventing the cerebral trauma or the damaged cerebral dura mater after an operation from being damaged and needing the repair of the artificial dura mater.
Disclosure of Invention
To solve the problems set forth in the background art described above. The invention provides a multifunctional artificial dura mater, which has the characteristic of diversified functions.
In order to achieve the purpose, the invention provides the following technical scheme: the utility model provides a multi-functional artificial dura mater, includes the diaphragm, the diaphragm includes anti-adhesion medicine, hemostatic medicine, anti-adhesion layer, nerve growth factor layer, nanometer silver dressing, waterproof material layer and cytoskeleton layer, wherein, the inboard on cytoskeleton layer is connected with waterproof material layer, one side that cell cytoskeleton layer was kept away from in waterproof material layer is connected with nanometer silver dressing, one side that waterproof material layer was kept away from in nanometer silver dressing is connected with nerve growth factor layer, one side that nanometer silver dressing was kept away from in nerve growth factor layer is connected with anti-adhesion layer, one side that nerve growth factor layer was kept away from in anti-adhesion layer is connected with anti-adhesion medicine, hemostatic medicine is filled up to anti-adhesion.
Preferably, the hemostatic agent is oxidized regenerated cellulose.
Preferably, the nano-silver dressing comprises gauze and a nano-silver medicament, wherein the interior of the gauze is filled with the nano-silver medicament.
Preferably, the nerve growth factor layer is adhered to the nano-silver dressing by means of spraying.
Compared with the prior art, the invention has the beneficial effects that:
1. the membrane is prepared from a cell scaffold layer, a waterproof material layer, a nano-silver dressing, a nerve growth factor layer, an anti-adhesion medicament and a hemostatic medicament, wherein the waterproof material layer has a good waterproof effect, the nano-silver dressing has the effects of strong sterilization effect, no drug resistance, strong permeability and long antibacterial action time, and has the effects of promoting self circulation of tissues around wounds, activating and promoting cell growth and promoting wound healing by being combined with the nerve growth factor layer, the anti-adhesion layer has the effect of preventing brain tissue from adhering, the hemostatic medicament has the effect of stopping bleeding, and various structures are matched with each other, so that the artificial dura mater has various functions of stopping bleeding, accelerating wound healing, preventing water and the like.
2. The hemostatic medicament is fully fused in the anti-adhesion medicament and is in close contact with the wound, and compared with the prior art, the hemostatic medicament has better hemostatic effect.
Drawings
FIG. 1 is a front view of the present invention;
FIG. 2 is a schematic cross-sectional view of the present invention;
in the figure: 1. a membrane; 11. anti-adhesion drugs; 12. a hemostatic drug; 13. an anti-adhesion layer; 14. a layer of nerve growth factor; 15. nano silver dressing; 16. a layer of water repellent material; 17. a cell scaffold layer.
Detailed Description
The technical solutions in the embodiments of the present invention will be clearly and completely described below with reference to the drawings in the embodiments of the present invention, and it is obvious that the described embodiments are only a part of the embodiments of the present invention, and not all of the embodiments. All other embodiments, which can be derived by a person skilled in the art from the embodiments given herein without making any creative effort, shall fall within the protection scope of the present invention.
Referring to fig. 1-2, the present invention provides the following technical solutions: a multifunctional artificial dura mater comprises a membrane 1, wherein the membrane 1 comprises an anti-adhesion medicament 11, a hemostatic medicament 12, an anti-adhesion layer 13, a nerve growth factor layer 14, a nano-silver dressing 15, a waterproof material layer 16 and a cell scaffold layer 17, wherein the inner side of the cell scaffold layer 17 is connected with the waterproof material layer 16, one side of the waterproof material layer 16, which is far away from the cell scaffold layer 17, is connected with the nano-silver dressing 15, in order that the nano-silver dressing 15 has a better using effect, in the embodiment, preferably, the nano-silver dressing 15 comprises gauze and nano-silver medicaments, wherein the nano-silver medicament is filled in the gauze, one side of the nano-silver dressing 15, which is far away from the waterproof material layer 16, is connected with the nerve growth factor layer 14, in order that the nerve growth factor layer 14 is adhered to the nano-silver dressing 15, in the embodiment, preferably, the nerve growth factor layer 14 is adhered to, an anti-adhesion layer 13 is connected to one side of the nerve growth factor layer 14, which is far away from the nano silver dressing 15, an anti-adhesion medicine 11 is connected to one side of the anti-adhesion layer 13, which is far away from the nerve growth factor layer 14, and a hemostatic medicine 12 is filled in the anti-adhesion medicine 11.
The nerve growth factor layer 14 in the invention is a known technology which is widely applied and used in daily life and has been disclosed, and the working principle is as follows: a nerve cell growth regulating factor with the biological functions of both neuron nutrition and promotion of growth of neurite has important regulation and control functions on the development, differentiation, growth, regeneration and expression of functional characteristics of central and peripheral neurons.
The nano silver dressing 15 in the invention is a known technology which is widely applied to daily life and has been disclosed, and the working principle is as follows: the metal silver simple substance with the particle size of nano grade is mostly about 25 nm, has strong inhibiting and killing effects on dozens of pathogenic microorganisms such as escherichia coli, gonococcus, chlamydia trachomatis and the like, and can not generate drug resistance.
The working principle and the using process of the invention are as follows: when the artificial dura mater is used, the membrane 1 is made of the cell scaffold layer 17, the waterproof material layer 16, the nano-silver dressing 15, the nerve growth factor layer 14, the anti-adhesion layer 13, the anti-adhesion medicine 11 and the hemostatic medicine 12, so that the artificial dura mater has various functions of stopping bleeding (the hemostatic medicine 12 has a hemostatic effect), accelerating wound healing (the nano-silver dressing 15 has the effects of strong bactericidal effect, no drug resistance, strong permeability and long antibacterial action time, is combined with the nerve growth factor layer 14, has the effects of promoting self circulation of tissues around wounds, activating and promoting cell growth and wound healing) and waterproofing (the waterproof material layer 16 has a good waterproof effect), and has good market competitiveness.
Although embodiments of the present invention have been shown and described, it will be appreciated by those skilled in the art that changes, modifications, substitutions and alterations can be made in these embodiments without departing from the principles and spirit of the invention, the scope of which is defined in the appended claims and their equivalents.
Claims (4)
1. The utility model provides a multi-functional artificial dura mater, includes diaphragm (1), its characterized in that: the membrane (1) comprises an anti-adhesion medicament (11), a hemostatic medicament (12), an anti-adhesion layer (13), a nerve growth factor layer (14), a nano silver dressing (15), a waterproof material layer (16) and a cell scaffold layer (17), wherein the inner side of the cell scaffold layer (17) is connected with a waterproof material layer (16), one side of the waterproof material layer (16) far away from the cell scaffold layer (17) is connected with a nano silver dressing (15), one side of the nano silver dressing (15) far away from the waterproof material layer (16) is connected with a nerve growth factor layer (14), one side of the nerve growth factor layer (14) far away from the nano silver dressing (15) is connected with an anti-adhesion layer (13), the side of the anti-adhesion layer (13) far away from the nerve growth factor layer (14) is connected with an anti-adhesion medicament (11), the anti-adhesion medicament (11) is internally filled with a hemostatic medicament (12).
2. The multifunctional artificial dura mater according to claim 1, wherein: the hemostatic drug (12) uses oxidized regenerated cellulose.
3. The multifunctional artificial dura mater according to claim 1, wherein: the nano-silver dressing (15) comprises gauze and a nano-silver medicament, wherein the nano-silver medicament is filled in the gauze.
4. The multifunctional artificial dura mater according to claim 1, wherein: the nerve growth factor layer (14) is adhered to the nano-silver dressing (15) in a spraying mode.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201911203247.2A CN110917402A (en) | 2019-11-29 | 2019-11-29 | Multifunctional artificial dura mater |
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| Application Number | Priority Date | Filing Date | Title |
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| CN201911203247.2A CN110917402A (en) | 2019-11-29 | 2019-11-29 | Multifunctional artificial dura mater |
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| CN110917402A true CN110917402A (en) | 2020-03-27 |
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