CN110903702A

CN110903702A - Antibacterial agent suitable for tipping paper

Info

Publication number: CN110903702A
Application number: CN201911243430.5A
Authority: CN
Inventors: 孙文国; 魏云波; 刘静; 张纪华
Original assignee: YUNNAN PHOENIX PAPER PRODUCTS Co Ltd
Current assignee: YUNNAN PHOENIX PAPER PRODUCTS Co Ltd
Priority date: 2019-12-06
Filing date: 2019-12-06
Publication date: 2020-03-24
Anticipated expiration: 2039-12-06
Also published as: CN110903702B

Abstract

The invention relates to an antibacterial agent suitable for tipping paper, which is characterized by comprising a non-biological component and a biological component; the non-biological component accounts for 0-100% of the total antibacterial agent by mass; the rest is biological components; the non-biological component is a component A, and the component A is polylysine; the biological components are Chinese medicinal materials: one or more of component C, component D, component E and component F. The invention fuses the special Chinese medicinal materials of minority nationality: the Dai medicine makes a certain contribution to protecting national treasure; the biological components of the invention have various formulas, are obvious in a plurality of Chinese medicinal material tests after being researched, and make a certain contribution to the development of the tobacco industry; the non-biological components are protected step by step according to the progressive effect relationship principle, and although the invention only has two non-biological components, the effect is wonderful; the product of the invention is as follows: the tipping paper with the antibacterial function is worth popularizing in the industry.

Description

Antibacterial agent suitable for tipping paper

Technical Field

The invention belongs to the technical field of an antibacterial agent formula for tipping paper; and includes the technical field of tipping paper products containing antimicrobial formulations.

Background

Tipping paper is defined as paper (often cork coloured or opaque white) used to wrap around the outside of a filter to adhere a filter rod to the end of a tobacco rod. Since tipping paper is the area of direct contact with the lips, its printing inks and coatings must meet food safety and hygiene standards. In addition, tipping paper has both certain requirements for water resistance and wet strength. Based on the increasingly stringent environmental protection and health requirements at present, the preparation requirements of the tipping paper become extremely high, and the following four points must be simultaneously achieved: 1) water resistance, 2) wet strength, 3) non-toxic, 4) antibacterial; and the antibacterial property is most important.

The packing and transportation of the tipping paper production process and the contact between the cigarette production process and the smoking of smokers all cause certain pollution to the tipping paper. Therefore, the tipping paper needs to be subjected to strict antibacterial treatment, so that the tipping paper has high antibacterial effect. In the production process of tipping paper, the selected or tested antibacterial agent must simultaneously satisfy three conditions to be effective: 1) the printing ink is not layered, and 2) the antibacterial effect is good; 3) is easily dissolved in alcohol. Therefore, the development of a tipping paper formula which simultaneously satisfies the four-point and antibacterial treatment conditions of tipping paper is a technical problem to be solved. Through search, the formula and the using method of the tipping paper antibacterial agent related to the formula are not found.

Disclosure of Invention

The present invention has been made to solve the above-mentioned problems, and an object of the present invention is to provide an antibacterial agent suitable for tipping paper.

The invention is realized by adopting the following technical scheme.

An antimicrobial agent suitable for tipping paper, the antimicrobial agent comprising a non-biological component and a biological component; the non-biological component accounts for 0-100% of the total antibacterial agent by mass; the rest is biological components; the non-biological component is a component A, and the component A is polylysine; the biological components are Chinese medicinal materials: one or more of component C, component D, component E and component F.

Furthermore, the non-biological component in the antibacterial agent also comprises a component B, wherein the component B is dodecyl dimethyl betaine.

Furthermore, the use parameters of the antibacterial agent in the tipping paper are as follows: respectively adding a certain amount of the component A and a certain amount of the component B into the ink, so that the mass percent of the component A contained in the ink is not less than 30g/L, B and not less than 10%.

Further, the ink of the present invention is such that the content of component A is 50g/L, B in terms of component mass% to 15%.

Further, the C component in the biological components of the antibacterial agent is one or a combination of more of astragalus, sophora flavescens, perilla, polygonum cuspidatum, ash bark, dark plum and clematis root.

Further, the D component in the biological components in the antibacterial agent is one or a combination of more of aloe, sappan wood, rhubarb, mint, common cnidium fruit, oriental wormwood, pyrrosia lingua, dendrobium, ginkgo leaf and evodia rutaecarpa.

Furthermore, the E component in the biological components in the antibacterial agent is one or a combination of more of Doynia delavayi, Docynia delavayi, small red garlic, white lead, and Sichuan pepper (zanthoxylum majus).

Further, the biological component in the antibacterial agent of the present invention includes a combination of the D component and the E component.

Furthermore, the F component in the biological components of the antibacterial agent is one or a combination of several of yam rhizome, rhizoma anemarrhenae, fructus cnidii, clove, dark plum and oriental wormwood.

Further, the preparation method of the component C or the component E comprises the steps of crushing the medicinal materials into powder by a crusher, adding water and alcohol for decoction, wherein the water adding amount is 15-20 times of the mass of the medicinal materials, and the alcohol adding amount is 5-10 times of the mass of the medicinal materials; decocting with slow fire for 3 hr; after the decoction is finished and the liquid medicine is cooled, ultrasonically dispersing the mixed liquid for 30min, then centrifuging at 4000rpm for 10min, and separating the liquid medicine and the medicine residues; soaking the obtained residue in 75% ethanol, and sealing at 4 deg.C; adding 1% chitosan acetic acid solution into the obtained upper layer liquid medicine, stirring at low speed for 15min, flocculating, and standing for 10h (this step can remove harmful heavy metals); after standing, centrifuging the liquid medicine at 4000rpm for 10min, collecting supernatant, concentrating the obtained supernatant under reduced pressure at 50-60 deg.C, and sealing for storage; the preparation method of the component D or the component F comprises the steps of putting the medicinal materials into a 70 ℃ oven, and drying for 3 h; crushing into powder with a crusher, soaking at 75% of normal temperature for 24h, ultrasonically dispersing the mixed solution for 30min, centrifuging at 4000rpm for 10min, and separating the liquid medicine and the dregs; soaking the obtained residue in 75% ethanol, and sealing at 4 deg.C; adding 1% chitosan acetic acid solution into the obtained upper layer liquid medicine, stirring at low speed for 15min, flocculating, and standing for 10 h; after standing, centrifuging the medicinal liquid at 4000rpm for 10min, collecting supernatant, concentrating the supernatant under reduced pressure at 50-60 deg.C, and sealing for storage.

The antibacterial agent of the invention is preferably sprayed when the tipping paper is used.

The invention comprises a tipping paper product containing the antimicrobial agent.

The invention has the beneficial effects that 1) the formula of the invention satisfies three conditions of no layering of printing ink, good antibacterial effect and easy dissolution in alcohol no matter whether the biological component or the non-biological component meets the technical requirement of reaching antibacterial property; 2) the invention expands the antibacterial formula of the tipping paper to two non-biological components and four biological components, but the antibacterial formula of the prior tipping paper is a broad spectrum but basically pure chemical components (non-biological components) and generally has metal ions, but the antibacterial formula containing the metal ions has more or less certain chemical toxicity. The polylysine contained in the formula is a substance generated by microorganisms, and is different from a bacteriostatic agent with pure chemical components in nature; 3) the invention fuses the special Chinese medicinal materials of minority nationality: dai medicine, the ingredients of the Dai medicine screened by the invention have practical and effective excellent efficacy on bacteriostasis, and also make a certain contribution to protecting national treasure; 4) the biological components of the invention have various formulas, are obvious in numerous traditional Chinese medicine experiments after research, have practical and effective excellent efficacy on the antibacterial efficacy, and make certain contribution to the development of the traditional Chinese medicine in the tobacco industry; 5) the non-biological components are protected step by step according to the progressive effect relationship principle, and although the invention only has two non-biological components, the effect is wonderful; 6) the product of the invention is as follows: the tipping paper with the antibacterial function is worth popularizing in the industry.

The invention is further explained below with reference to the drawings and the detailed description.

Drawings

FIG. 1 is a schematic diagram showing the effect of the antibacterial agent of the present invention.

Detailed Description

The technical characteristic test of the invention is briefly described.

A first experimental stage:

first, experimental method and evaluation standard

1. Refer to the national standard GB 15979-2002 of hygienic Standard for Disposable sanitary articles.

2. A certain amount of polylysine was dissolved in distilled water, mixed with ink at a ratio of 1:3 to give polylysine final concentrations of 50g/L and 100g/L, respectively, and applied to 3X 2cm paper sheets, respectively, and then dried to carry out the experiment.

II, experimental results:

the bacteriostasis rate is calculated as X ═ (A-B)/Ax100%

In the formula: x is the bacteriostasis rate, and the unit is percentage (%)

A is the average colony number of the control sample, and the unit is one

B is the average colony number of the tested sample, and the unit is one. The experiment was repeated 3 times.

TABLE 1 inhibition of Staphylococcus aureus by epsilon-polylysine (polylysine 50g/L)

TABLE 2 inhibition of Staphylococcus aureus by epsilon-polylysine (polylysine 100g/L)

TABLE 3 inhibition of E.coli by epsilon-polylysine (polylysine 50g/L)

TABLE 4 inhibition of E.coli by epsilon-polylysine (polylysine 100g/L)

Third, conclusion and description

1. The ink can change the property after being mixed with water and is easy to delaminate.

2. Polylysine has extremely low solubility in alcohol and is slightly soluble in alcohol; the solubility in water is very high, and the water can still dissolve at 400 g/L.

3. The ink contains a large amount of mixed bacteria.

4. In general, compared with staphylococcus aureus, the poly-lysine has an inhibiting effect on escherichia coli, when the concentration is 50g/L, the epsilon-poly-lysine has an inhibiting effect on the escherichia coli, and when the concentration is 100g/L, the inhibiting effect is further enhanced.

Experimental stage two (partially successful experiment):

first, experimental method and evaluation standard

2. Experimental groups: certain amounts of polylysine and dodecyl dimethyl betaine aqueous solutions are respectively added into the ink, so that the ink contains 50g/L of polylysine and 15% of dodecyl dimethyl betaine. The ink was applied to a 3X 2cm piece of paper and the test was carried out after drying.

Control group: the blank ink was applied to a 3X 2cm piece of paper and allowed to dry before the experiment.

II, experimental results:

1. the inhibition condition of the compound ink to escherichia coli is as follows:

TABLE 5 inhibition of E.coli by the formulated inks

Bacteriostasis rate (colibacillus) ═ 100% (left figure 1)

2. The inhibition condition of the compound printing ink to staphylococcus aureus is as follows:

TABLE 6 inhibition of E.coli by the formulated inks

Bacteriostasis rate (staphylococcus aureus) ═ 100% (in figure 1)

Thirdly, conclusion and description:

1. after the polylysine and the dodecyl dimethyl betaine aqueous solution are added into the ink, the ink is not subjected to layered denaturation;

2. from the results, when the content of the polylysine in the ink is 50g/L and the content of the dodecyl dimethyl betaine is 15%, the effect is good, and the antibacterial effect is strong.

The same experimental parameters were omitted:

the bacteriostasis rate of the component C or the component E after the preparation method is as follows:

the bacteriostasis rate (staphylococcus aureus) is 95.5 percent;

the bacteriostasis rate (escherichia coli) is 96.8%;

wherein the component C comprises the following components in parts by weight: 50 parts of clematis root, 5 parts of sophora flavescens, 5 parts of perilla, 10 parts of giant knotweed, 20 parts of astragalus, 20 parts of dark plum and 5 parts of ash bark.

Wherein the component E comprises the following components in parts by weight: 30 parts of arundina graminifolia, 30 parts of small red garlic, 20 parts of docynia delavayi, 10 parts of whiteflower leadword root and 10 parts of large-leaved stinky pepper.

The antibacterial rate of the component D or the component F after the preparation method is used is as follows:

the bacteriostasis rate (staphylococcus aureus) is 96.5 percent;

the bacteriostasis rate (colibacillus) is 94.6 percent;

wherein the component D comprises the following components in parts by weight: 30 parts of aloe, 10 parts of sappan wood, 5 parts of rheum officinale, 3 parts of mint, 5 parts of fructus cnidii, 5 parts of oriental wormwood, 5 parts of pyrrosia lingua, 10 parts of dendrobium, 3 parts of ginkgo leaf and 2 parts of fructus evodiae.

Wherein the component F comprises the following components in parts by weight: 50 parts of yam rhizome, 20 parts of rhizoma anemarrhenae, 10 parts of fructus cnidii, 10 parts of clove, 5 parts of dark plum and 5 parts of oriental wormwood.

The antibacterial rate of the component D and the component E combined by the preparation method respectively is as follows:

the bacteriostasis rate (staphylococcus aureus) is 100 percent;

the bacteriostatic ratio (escherichia coli) is 100% (fig. 1 right).

Wherein the component D comprises the following components in parts by weight: 30 parts of aloe, 10 parts of sappan wood, 5 parts of rheum officinale, 3 parts of mint, 5 parts of fructus cnidii, 5 parts of oriental wormwood, 5 parts of pyrrosia lingua, 10 parts of dendrobium, 3 parts of ginkgo leaf and 2 parts of fructus evodiae; the component E comprises the following components in parts by weight: 30 parts of arundina graminifolia, 30 parts of small red garlic, 20 parts of docynia delavayi, 10 parts of whiteflower leadword root and 10 parts of large-leaved stinky pepper.

The traditional Chinese medicinal materials are only experimental contents of actual parts by weight, and all the traditional Chinese medicinal materials are in the protection scope of the invention on the basis of conforming to the compatibility principle of the traditional Chinese medicines.

The above description is only a part of specific embodiments of the present invention (since the formula of the present invention belongs to the numerical range, the embodiments are not exhaustive, and the protection scope of the present invention is subject to the numerical range and other technical point ranges), and the detailed contents or common knowledge known in the schemes are not described too much. It should be noted that the above-mentioned embodiments do not limit the present invention in any way, and all technical solutions obtained by means of equivalent substitution or equivalent transformation for those skilled in the art are within the protection scope of the present invention. The scope of the claims of the present application shall be determined by the contents of the claims, and the description of the embodiments and the like in the specification shall be used to explain the contents of the claims.

Claims

1. An antimicrobial agent suitable for tipping paper, wherein the antimicrobial agent comprises a non-biological component and a biological component; the non-biological component accounts for 0-100% of the total antibacterial agent by mass; the rest is biological components; the non-biological component is a component A, and the component A is polylysine; the biological components are Chinese medicinal materials: one or more of component C, component D, component E and component F.

2. The antibacterial agent for tipping paper as claimed in claim 1, wherein the non-biological component of the antibacterial agent further comprises a component B, wherein the component B is dodecyl dimethyl betaine.

3. The antibacterial agent for tipping paper according to claim 2, wherein the parameters of the antibacterial agent used in tipping paper are: respectively adding a certain amount of the component A and a certain amount of the component B into the ink, so that the mass percent of the component A contained in the ink is not less than 30g/L, B and not less than 10%.

4. The antibacterial agent for tipping paper according to claim 3, wherein the component A is contained in the ink in an amount of 50g/L, B in an amount of 15% by mass.

5. The antibacterial agent for tipping paper according to claim 1, wherein the C component in the biological components of the antibacterial agent is one or more of radix astragali, radix Sophorae Flavescentis, Perillae herba, rhizoma Polygoni Cuspidati, cortex Fraxini, mume fructus, and radix Clematidis.

6. The antibacterial agent for tipping paper according to claim 1, wherein the D component in the biological components in the antibacterial agent is one or more of aloe, sappan wood, rhubarb, mint, common cnidium fruit, oriental wormwood, pyrrosia lingua, dendrobium nobile, ginkgo leaf and evodia rutaecarpa.

7. The antibacterial agent for tipping paper according to claim 1, wherein the component E in the biological components in the antibacterial agent is one or more of Doynia delavayi, Docynia delavayi, Garlic herb, Plumbago zeylanica, and Zanthoxylum bungeanum Maxim.

8. The antimicrobial agent for tipping paper as claimed in claim 1, wherein the biological component of the antimicrobial agent comprises a combination of component D and component E.

9. The antibacterial agent for tipping paper according to claim 1, wherein the component F in the biological components of the antibacterial agent is one or more of rhizoma Dioscoreae Septemlobae, rhizoma anemarrhenae, fructus Cnidii, flos Caryophylli, mume fructus, and herba Artemisiae Scopariae.

10. The antibacterial agent for tipping paper according to claim 5, wherein the component C or E is prepared by pulverizing the raw materials into powder with a pulverizer, decocting with water and ethanol, wherein the water amount is 15-20 times of the raw materials, and the ethanol amount is 5-10 times of the raw materials; decocting with slow fire for 3 hr; after the decoction is finished and the liquid medicine is cooled, ultrasonically dispersing the mixed liquid for 30min, then centrifuging at 4000rpm for 10min, and separating the liquid medicine and the medicine residues; soaking the obtained residue in 75% ethanol, and sealing at 4 deg.C; adding 1% chitosan acetic acid solution into the obtained upper layer liquid medicine, stirring at low speed for 15min, flocculating, and standing for 10 h; after standing, centrifuging the liquid medicine at 4000rpm for 10min, collecting supernatant, concentrating the obtained supernatant under reduced pressure at 50-60 deg.C, and sealing for storage; the preparation method of the component D or the component F comprises the steps of putting the medicinal materials into a 70 ℃ oven, and drying for 3 h; crushing into powder with a crusher, soaking at 75% of normal temperature for 24h, ultrasonically dispersing the mixed solution for 30min, centrifuging at 4000rpm for 10min, and separating the liquid medicine and the dregs; soaking the obtained residue in 75% ethanol, and sealing at 4 deg.C; adding 1% chitosan acetic acid solution into the obtained upper layer liquid medicine, stirring at low speed for 15min, flocculating, and standing for 10 h; after standing, centrifuging the medicinal liquid at 4000rpm for 10min, collecting supernatant, concentrating the supernatant under reduced pressure at 50-60 deg.C, and sealing for storage.