CN110890795B - Tumor thermal ablation device based on non-contact power supply - Google Patents
Tumor thermal ablation device based on non-contact power supply Download PDFInfo
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- CN110890795B CN110890795B CN201910972750.8A CN201910972750A CN110890795B CN 110890795 B CN110890795 B CN 110890795B CN 201910972750 A CN201910972750 A CN 201910972750A CN 110890795 B CN110890795 B CN 110890795B
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- H—ELECTRICITY
- H02—GENERATION; CONVERSION OR DISTRIBUTION OF ELECTRIC POWER
- H02J—CIRCUIT ARRANGEMENTS OR SYSTEMS FOR SUPPLYING OR DISTRIBUTING ELECTRIC POWER; SYSTEMS FOR STORING ELECTRIC ENERGY
- H02J50/00—Circuit arrangements or systems for wireless supply or distribution of electric power
- H02J50/20—Circuit arrangements or systems for wireless supply or distribution of electric power using microwaves or radio frequency waves
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- H—ELECTRICITY
- H05—ELECTRIC TECHNIQUES NOT OTHERWISE PROVIDED FOR
- H05B—ELECTRIC HEATING; ELECTRIC LIGHT SOURCES NOT OTHERWISE PROVIDED FOR; CIRCUIT ARRANGEMENTS FOR ELECTRIC LIGHT SOURCES, IN GENERAL
- H05B3/00—Ohmic-resistance heating
- H05B3/0019—Circuit arrangements
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- H—ELECTRICITY
- H05—ELECTRIC TECHNIQUES NOT OTHERWISE PROVIDED FOR
- H05B—ELECTRIC HEATING; ELECTRIC LIGHT SOURCES NOT OTHERWISE PROVIDED FOR; CIRCUIT ARRANGEMENTS FOR ELECTRIC LIGHT SOURCES, IN GENERAL
- H05B3/00—Ohmic-resistance heating
- H05B3/0033—Heating devices using lamps
- H05B3/0085—Heating devices using lamps for medical applications
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Abstract
The invention discloses a tumor thermal ablation device based on non-contact power supply. The device includes: the electromagnetic induction device comprises an electromagnetic generation device, a transmitting coil, a receiving coil and an electric heating element; the output end of the electromagnetic generating device is connected with the transmitting coil, and the electromagnetic generating device is used for generating electromagnetic energy and transmitting the electromagnetic energy to the transmitting coil; the receiving coil and the transmitting coil are arranged correspondingly and used for receiving the electromagnetic energy transmitted by the transmitting coil and converting the electromagnetic energy into electric energy; the output end of the receiving coil is connected with the electric heating element; when a tumor thermal ablation treatment is performed, the electrical heating elements are arranged at the tumor area to be treated. The tumor thermal ablation device based on non-contact power supply adopts the non-contact power supply technology, directly guides electric energy to a tumor tissue part, and realizes thermal ablation on the tumor tissue through temperature control heating of the electric heating element; the micro-fluidic chip can realize accurate positioning in a minimally invasive scale, has good conformality, uniform and adjustable thermal field distribution, small wound to a human body and small damage to normal tissues.
Description
Technical Field
The invention relates to the technical field of biomedicine electronics, in particular to a tumor thermal ablation device based on non-contact power supply.
Background
Malignant tumor has the characteristics of high morbidity and high recurrence rate, and becomes one of the major diseases threatening human health. Traditional methods of treating tumors include surgical resection, radiation therapy, and chemotherapy. In recent years, with the rapid development of biomedical engineering technology, the tumor thermal ablation technology successfully realizes the clinical application of tumor treatment, and opens up a new way for tumor treatment.
Tumor thermal ablation is an in-situ inactivation technology which is used for heating tissues to generate biological effects by using a physical method aiming at one or more specific tumor focuses in a certain organ or tissue and directly causing irreversible damage or coagulation necrosis of tumor cells. Generally, microwave or radio frequency technology and other technologies are adopted to generate a heating source, a target tumor and a surrounding normal tissue of 0.5-1 cm are ablated to the maximum degree by taking the tumor as a center, the target tumor and the surrounding normal tissue are heated to an effective treatment temperature range and maintained for a specific time, the molecular structure of tumor cells is changed, the activity of lysosomes is enhanced, and the purposes of killing the tumor cells and treating the tumor are achieved. Compared with the traditional method, the thermal ablation has the advantages of high safety, few complications, conformity, micro-invasion, good repeatability and the like, and is an effective tumor treatment means besides the surgical resection, the radiotherapy and the chemotherapy.
The ablation technology taking radio frequency as a heat source occurs in a current mode, the electrical conductivity and impedance of tissues limit the ablation range, the influence of carbonization, tissue drying and heat sedimentation effects is large, and the formed thermal field is uneven in distribution and poor in controllability. The ablation technology using microwave as a heat source directly transmits energy to a tumor region in a microwave transmission mode, is greatly influenced by the depth of penetrating tissues, is easy to cause thermal damage to normal tissues outside a target region, and is imperfect in equipment and unstable in effect.
Disclosure of Invention
The invention aims to provide a tumor thermal ablation device based on non-contact power supply, so as to improve the uniformity of thermal field distribution and further improve the positioning accuracy of tumor thermal ablation.
In order to achieve the purpose, the invention provides the following scheme:
a non-contact power supply based tumor thermal ablation apparatus comprising: the electromagnetic induction device comprises an electromagnetic generation device, a transmitting coil, a receiving coil and an electric heating element;
the output end of the electromagnetic generating device is connected with the transmitting coil, and the electromagnetic generating device is used for generating electromagnetic energy and transmitting the electromagnetic energy to the transmitting coil; the receiving coil is arranged corresponding to the transmitting coil and used for receiving the electromagnetic energy transmitted by the transmitting coil and converting the electromagnetic energy into electric energy; the output end of the receiving coil is connected with the electric heating element; when tumor thermal ablation treatment is carried out, the electric heating element is arranged at the tumor area to be treated.
Optionally, the electromagnetic generating device includes: a high frequency signal generator and a power driver; the output end of the high-frequency signal generator is connected with the power driver, the output end of the power driver is connected with the transmitting coil, the high-frequency signal generator is used for generating a high-frequency electromagnetic signal with modulation information, and the power generator is used for performing power amplification on the high-frequency electromagnetic signal.
Optionally, the method further includes: the receiving coil is connected with the electric heating element through the rectifying and filtering circuit and the linear voltage stabilizing device; the output end of the receiving coil is connected with the input end of the rectifying and filtering circuit, the output end of the rectifying and filtering circuit is connected with the linear voltage stabilizing device, and the output end of the linear voltage stabilizing device is connected with the electric heating element; the receiving coil is used for converting the electromagnetic energy into high-frequency alternating current electric energy, the rectifying and filtering circuit is used for converting the high-frequency alternating current electric energy into direct current electric energy, and the linear voltage stabilizing device is used for stabilizing the direct current electric energy.
Optionally, the device further comprises a control circuit and a temperature sensor; the receiving coil is connected with the electric heating element through the control circuit, and the temperature sensor is arranged in the tumor area to be treated; the control circuit is used for adjusting the heating parameters of the heating element according to the measurement data of the temperature sensor.
Optionally, the number of the temperature sensors is multiple, and the multiple temperature sensors are dispersedly arranged in the tumor region to be treated.
Optionally, the number of the electric heating elements is multiple, the shape of each electric heating element is adjustable, and the shapes of the electric heating elements are adjusted according to the shape of the tumor area to be treated, so that the heating areas of the electric heating elements are uniformly distributed in the tumor area to be treated.
Optionally, the control circuit includes a multi-point closed-loop control circuit and a microcontroller; the microcontroller is used for receiving the measurement data of the temperature sensors and adjusting the heating parameters of the heating elements through the multi-point closed-loop control circuit by adopting a PID control strategy.
Optionally, the tumor treatment device further comprises a display device, wherein the display device is connected with the output end of the microcontroller and is used for displaying the temperature data of the tumor area to be treated in real time.
According to the specific embodiment provided by the invention, the invention discloses the following technical effects:
(1) the positioning performance is good: when in use, the electric heating element can be accurately placed in a tumor area through a minimally invasive technology;
(2) the conformality is good: parameters such as the number, the distribution density, the length, the arrangement shape and the like of the electric heating elements are adjusted according to the size, the shape and the area of the tumor to adapt to the tumor to be treated, so that the tumor can be well thermally ablated, and the adverse effect on the surrounding normal tissues can be avoided.
(3) The thermal field is uniform and controllable: the multipoint closed-loop control circuit realizes the temperature measurement and control of the tumor area, provides different heating power and heating time for each electric heating element distributed in the tumor tissue to realize the control of the uniformity of the thermal field, and can achieve the effect of sustainable thermal therapy on the tumor;
(4) setting and real-time control heating: the temperature information of the tumor tissue can be sent to an in-vitro display device in real time, the tumor temperature is displayed on the display device, and then the heating system parameters are set in real time through a microcontroller;
(5) safety and convenience are achieved: the micro-invasive technique and the operation traction means are adopted to arrange the tiny heating wire elements, the space induction coupling technique is adopted, the operation is convenient and fast, the transmission efficiency is high, and the heat damage of normal tissues outside the target area can be effectively reduced.
Drawings
In order to more clearly illustrate the embodiments of the present invention or the technical solutions in the prior art, the drawings needed to be used in the embodiments will be briefly described below, and it is obvious that the drawings in the following description are only some embodiments of the present invention, and it is obvious for those skilled in the art to obtain other drawings without inventive exercise.
Fig. 1 is a schematic structural diagram of a tumor thermal ablation apparatus based on non-contact power supply in embodiment 1 of the present invention;
FIG. 2 is a schematic view of a tumor thermal ablation apparatus based on non-contact power supply in embodiment 2 of the present invention;
FIG. 3 is a schematic diagram of the placement of the electrothermal element of the tumor thermal ablation device based on non-contact power supply in the tumor according to embodiment 2 of the present invention;
fig. 4 is a schematic diagram of the placement of the electric heating element of the tumor thermal ablation device based on non-contact power supply in the tumor in embodiment 3 of the invention.
Detailed Description
The technical solutions in the embodiments of the present invention will be clearly and completely described below with reference to the drawings in the embodiments of the present invention, and it is obvious that the described embodiments are only a part of the embodiments of the present invention, and not all of the embodiments. All other embodiments, which can be derived by a person skilled in the art from the embodiments given herein without making any creative effort, shall fall within the protection scope of the present invention.
In order to make the aforementioned objects, features and advantages of the present invention comprehensible, embodiments accompanied with figures are described in further detail below.
Example 1
Fig. 1 is a schematic structural diagram of a tumor thermal ablation apparatus based on non-contact power supply in embodiment 1 of the present invention. As shown in fig. 1, the tumor thermal ablation apparatus based on non-contact power supply in this embodiment includes: the electromagnetic induction device comprises an electromagnetic generation device, a transmitting coil, a receiving coil and an electric heating element; the output end of the electromagnetic generating device is connected with the transmitting coil, and the electromagnetic generating device is used for generating electromagnetic energy and transmitting the electromagnetic energy to the transmitting coil; the receiving coil is arranged corresponding to the transmitting coil and used for receiving the electromagnetic energy transmitted by the transmitting coil and converting the electromagnetic energy into electric energy; the output end of the receiving coil is connected with the electric heating element; when tumor thermal ablation treatment is carried out, the electric heating element is arranged at the tumor area to be treated.
Specifically, the electromagnetic generating device comprises a high-frequency signal generator and a power driver; the output end of the high-frequency signal generator is connected with the power driver, the output end of the power driver is connected with the transmitting coil, the high-frequency signal generator is used for generating a high-frequency electromagnetic signal with modulation information, and the power generator is used for performing power amplification on the high-frequency electromagnetic signal.
The receiving coil is connected with the electric heating element through a rectifying and filtering circuit and a linear voltage stabilizing device; the output end of the receiving coil is connected with the input end of the rectifying and filtering circuit, the output end of the rectifying and filtering circuit is connected with the linear voltage stabilizing device, and the output end of the linear voltage stabilizing device is connected with the electric heating element; the receiving coil is used for converting the electromagnetic energy into high-frequency alternating current electric energy, the rectifying and filtering circuit is used for converting the high-frequency alternating current electric energy into direct current electric energy, and the linear voltage stabilizing device is used for stabilizing the direct current electric energy.
The receiving coil is connected with the electric heating element through a control circuit, and the control circuit comprises a receiving circuit and a microcontroller; the microcontroller is used for receiving the measurement data of the temperature sensors and adjusting the heating parameters of the heating elements by adopting a PID control strategy through a multi-point closed-loop control circuit. The temperature sensor is arranged in the tumor area to be treated; the control circuit is used for adjusting the heating parameters of the heating element according to the measurement data of the temperature sensor.
The number of the temperature sensors is multiple, and the temperature sensors are distributed in the tumor area to be treated. The number of the electric heating elements is multiple, the shape of each electric heating element can be adjusted, and the shapes of the electric heating elements are adjusted according to the shape of a tumor area to be treated, so that the heating areas of the electric heating elements are uniformly distributed in the tumor area to be treated.
The embodiment also comprises a display device, wherein the display device is connected with the output end of the microcontroller through a transmitting circuit and is used for displaying the temperature data of the tumor area to be processed in real time.
Example 2
Fig. 2 is a schematic view of a tumor thermal ablation apparatus based on non-contact power supply in embodiment 2 of the present invention. As shown in fig. 2, the tumor thermal ablation apparatus based on non-contact power supply of the present embodiment employs a non-contact power supply technology, and introduces electric energy directly to the tumor tissue site, and implements thermal ablation on the tumor tissue through temperature-controlled heating by the electric heating element. The tumor thermal ablation device based on non-contact power supply comprises an external energy transmitting part and an internal energy receiving part, wherein the external energy transmitting part comprises a signal generating and power driver 1 and a transmitting coil 2, the signal generating and power driver 1 generates a high-frequency signal with modulation information through a high-frequency signal generator, the power driver amplifies the power of the high-frequency signal to a proper level and then sends the high-frequency signal to the transmitting coil 2, and the transmitting coil 2 transmits electromagnetic energy. Wherein the power driver adopts a push-pull structure.
The internal energy receiving part comprises a receiving coil 3, a rectifying, filtering and voltage stabilizing circuit 4, a microcontroller 5, an electric heating element 6 and a temperature sensor 8. The receiving coil 3 is opposite to the transmitting coil 2 in front, and the larger the overlapping area of the two coils is, the higher the energy transmission efficiency is. The receiving coil 3 converts the electromagnetic energy in the space into high-frequency alternating current electric energy, the high-frequency alternating current electric energy is converted into direct current electric energy through a rectifying and filtering circuit of a rectifying and filtering voltage stabilizing circuit 4, a linear voltage stabilizing device stabilizes the direct current voltage, and then the current is led into an electric heating element 6 arranged in a tumor area 7 through a control circuit and a low-resistance lead. Wherein, the microcontroller 5 belongs to one part of the control circuit, the control circuit controls the heating power, the controlled power transmits the heating energy to the electric heating element 6 through the low-resistance lead, and the electric heating element 6 controls and heats the tumor tissue.
Specifically, the control circuit comprises a multi-point closed-loop control circuit and a microcontroller 5. The multipoint closed-loop control circuit realizes the temperature measurement and control of the tumor area. The multi-point is to perform multi-point temperature sampling on the controlled object, and the closed-loop control is to calculate parameters such as the current temperature, the heat capacity and the like of the controlled object to obtain heating power so as to improve the temperature control precision. The microcontroller 5 can realize the heating temperature control of the tumor region 7, and the temperature control algorithm adopts an intelligent self-tuning PID temperature control algorithm.
In this embodiment, after the electric energy is directly introduced into the tumor region 7, the tumor tissue is thermally ablated by the temperature-controlled heating of the electric heating element 6, and a heating system including a heating temperature, a heating time, and a heating temperature gradient curve for the tumor tissue is set and controlled in real time by the in vivo and in vitro transceiver, the closed-loop control circuit, and the microcontroller 5. The heating system is determined by an executor according to experimental experience in advance, the heating system is transmitted to the multi-point closed-loop controller through the transmitting coil, and the multi-point closed-loop controller executes the set heating system. Such a heating regime enables a controlled temperature heating of only the tumor tissue, while minimizing the thermal influence on the surrounding normal tissue 9, achieving the dual purpose of thermal ablation of the tumor and protection of the normal tissue. Wherein, the heating system which can be set and controlled in real time is to send the temperature information of the tumor tissue to the in-vitro device through the transmitting circuit and display the tumor temperature on the in-vitro device; the microcontroller 5 receives the set heating regime parameters via a receiving circuit.
In the embodiment, the tumor tissue is heated by adopting a multi-point electric heating element, and different areas of the tumor are heated by adopting a plurality of electric heating elements, so that the heating effect is as uniform as possible; the multipoint temperature sensor 8 is adopted for measuring temperature, and the heating power of the electric heating element 6 is controlled according to the target temperature obtained by measuring the temperature.
The high-frequency signal of the embodiment is transmitted to the transmitting coil 2 through the power driver after being generated, the transmitting coil 2 is inductively coupled with the receiving coil 3 implanted under the skin of the surface layer in the body to realize energy transfer, the electromagnetic energy is finally converted into stable direct current electric energy through the rectification filter and the voltage stabilizing circuit 4, and the current is led into the electric heating element 6 arranged in the tumor region 7 through the multi-point closed-loop control circuit, the microcontroller 5 and the low-resistance lead. The heating system including the heating temperature, the heating time and the heating temperature gradient curve of the tumor tissue is set and controlled in real time through the in-vivo and in-vitro transceiver, the closed-loop control circuit and the microcontroller 5. The multi-point closed-loop control circuit measures and controls the temperature of a tumor area, the microcontroller controls the tumor heating temperature, the temperature control algorithm adopts an intelligent self-tuning PID temperature control algorithm, the temperature information of tumor tissues is sent to an in-vitro device through the transmitting circuit, the tumor temperature is displayed on the in-vitro device, and the microcontroller receives and sets heating system parameters through the receiving circuit. As shown in fig. 3, fig. 3 shows that the electric heating elements of the tumor thermal ablation device based on non-contact power supply are placed in the tumor, four electric heating elements are placed in the tumor block at equal intervals to realize multi-point heating of tumor tissues, a multi-point temperature sensor is placed near the heating elements to measure temperature, and the heating power of the electric heating elements is controlled according to the target temperature obtained by measuring the temperature.
Example 3
The implementation process of this embodiment is substantially the same as that of embodiment 2, except that the form of the tumor mass in this embodiment is different from that in embodiment 2, and therefore, the arrangement manner of the heating elements in this embodiment is different from that in embodiment 2. Fig. 4 is a schematic diagram showing placement of electric heating elements of a tumor thermal ablation apparatus based on non-contact power supply in an embodiment 3 of the present invention inside a tumor, as shown in fig. 4, in this embodiment, 1 electric heating element is placed in a tumor block, two electric heating elements horizontally surround the tumor block, two electric heating elements vertically surround the tumor block, so as to realize multipoint heating of tumor tissue, a multipoint temperature sensor is placed near the heating elements to measure temperature, and heating power of the electric heating elements is controlled according to a target temperature obtained by measuring temperature.
The embodiments in the present description are described in a progressive manner, each embodiment focuses on differences from other embodiments, and the same and similar parts among the embodiments are referred to each other.
The principles and embodiments of the present invention have been described herein using specific examples, which are provided only to help understand the method and the core concept of the present invention; meanwhile, for a person skilled in the art, according to the idea of the present invention, the specific embodiments and the application range may be changed. In view of the above, the present disclosure should not be construed as limiting the invention.
Claims (6)
1. A tumor thermal ablation device based on non-contact power supply is characterized by comprising: the electromagnetic induction device comprises an electromagnetic generation device, a transmitting coil, a receiving coil and an electric heating element;
the output end of the electromagnetic generating device is connected with the transmitting coil, and the electromagnetic generating device is used for generating electromagnetic energy and transmitting the electromagnetic energy to the transmitting coil; the receiving coil is arranged corresponding to the transmitting coil and used for receiving the electromagnetic energy transmitted by the transmitting coil and converting the electromagnetic energy into electric energy; the output end of the receiving coil is connected with the electric heating element; when tumor thermal ablation treatment is carried out, the electric heating element is arranged in a tumor area to be treated, the tumor tissue is heated by adopting a multi-point electric heating element, and different areas of the tumor area are heated by adopting a plurality of electric heating elements;
the electromagnetic generating device also comprises a control circuit and a temperature sensor; the receiving coil is connected with the electric heating element through the control circuit, and the temperature sensor is arranged in the tumor area to be treated; the control circuit is used for adjusting the heating parameters of the electric heating element according to the measurement data of the temperature sensor;
the number of the temperature sensors is multiple, and the temperature sensors are distributed in the tumor area to be treated.
2. The non-contact power supply based oncology thermal ablation device according to claim 1, wherein the electromagnetic generating device comprises: a high frequency signal generator and a power driver; the output end of the high-frequency signal generator is connected with the power driver, the output end of the power driver is connected with the transmitting coil, the high-frequency signal generator is used for generating a high-frequency electromagnetic signal with modulation information, and the power driver is used for performing power amplification on the high-frequency electromagnetic signal.
3. The non-contact power supply based oncology thermal ablation device according to claim 1, further comprising: the receiving coil is connected with the electric heating element through the rectifying and filtering circuit and the linear voltage stabilizing device; the output end of the receiving coil is connected with the input end of the rectifying and filtering circuit, the output end of the rectifying and filtering circuit is connected with the linear voltage stabilizing device, and the output end of the linear voltage stabilizing device is connected with the electric heating element; the receiving coil is used for converting the electromagnetic energy into high-frequency alternating current electric energy, the rectifying and filtering circuit is used for converting the high-frequency alternating current electric energy into direct current electric energy, and the linear voltage stabilizing device is used for stabilizing the direct current electric energy.
4. The tumor thermal ablation device based on non-contact power supply according to claim 1, wherein the number of the electric heating elements is plural, and the shape of each electric heating element is adjustable, and the shape of the plural electric heating elements is adjusted according to the shape of the tumor region to be treated, so that the heating areas of the plural electric heating elements are uniformly distributed in the tumor region to be treated.
5. The non-contact power supply based oncology thermal ablation device according to claim 1, wherein the control circuit comprises a multi-point closed loop control circuit and a microcontroller; the microcontroller is used for receiving the measurement data of the temperature sensors and adjusting the heating parameters of the electric heating elements through the multi-point closed-loop control circuit by adopting a PID control strategy.
6. The tumor thermal ablation device based on non-contact power supply according to claim 5, further comprising a display device connected to the output of the microcontroller for displaying the temperature data of the tumor area to be treated in real time.
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