CN105615998B - A kind of atherosclerosis guiding target treatment device - Google Patents

A kind of atherosclerosis guiding target treatment device Download PDF

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Publication number
CN105615998B
CN105615998B CN201610112668.4A CN201610112668A CN105615998B CN 105615998 B CN105615998 B CN 105615998B CN 201610112668 A CN201610112668 A CN 201610112668A CN 105615998 B CN105615998 B CN 105615998B
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China
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radio frequency
treatment
cold medium
microelectrode
control module
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CN201610112668.4A
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Chinese (zh)
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CN105615998A (en
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张爱丽
徐学敏
邹金成
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上海交通大学
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Abstract

The invention provides a kind of atherosclerosis guiding target treatment device, including at least one treatment sacculus and treatment control system, the outer surface for the treatment of sacculus is provided with multiple radio frequency microelectrode arrays and temperature sensor that can work independently, treat the cold medium peripheral passage being internally provided with for accommodating and circulating cold medium of sacculus, control system is treated by controlling cold medium loop control module to adjust the flow velocity of the cold medium in cold medium peripheral passage, to adjust temperature, and the output signal of each radio frequency output port is controlled by RF therapy control module, its output signal can be the same or different, so that radio frequency microelectrode may be at different on off states and different rf frequencies.The present invention is easy to operate, and complexity is low, and noninvasive or minimally invasive targeted therapy can be carried out to atherosclerotic plaque.

Description

A kind of atherosclerosis guiding target treatment device

Technical field

The present invention relates to biomedical engineering field, and in particular to a kind of atherosclerosis guiding target treatment device.

Background technology

Atherosclerosis (Atherosclerosis) harmfulness is big, and the incidence of disease is high, in the field such as medical science and biology one All it has been the emphasis of research since straight.Atherosclerosis can cause the attenuating of arterial elasticity and arterial lumen to narrow, and then trigger Local organization ischemic, myocardial infarction, apoplexy, angina pectoris etc..Atherosclerosis mainly originate from endarterium lipidosis with And the propagation of smooth muscle cell, finally cause inner membrance fibrous thickening, and form atheromatous plaque.

However, at present in most important treatment method, blood vessel is remolded by angioplasty, expands vessel lumen, it is postoperative Reangiostenosis easily occurs, and kills the smooth muscle cell for causing hemadostewnosis rapidly using ablation, can cause endovascular Biological tissue's environment is seriously damaged, and postoperative restenosis incidence is very high.Because the endothelial cell of vascular wall inner membrance has weight The regulatory function wanted, the propagation that the smooth muscle cell of tunicae media vasorum can be adjusted by discharging cell factor;Conventional method due to Mechanical presses, blood vessel is heated or freezed, different degrees of damage can be all caused to vascular endothelial cell.It is to cause blood vessel pipe One of main reason of chamber ISR.

Existing radio frequency and freezing model are used widely in the treatment of clinical major disease.As Cai et al. is utilized Radio frequency penetration effect heating tumour, the tumour at epidermis position is regarded the spheroidal structure of radius very little, electric field and temperature is established with this Degree field model studies its Temperature Distribution;The tumour at different radii different tissues position is considered as thermal conductivity factor perseverance by S.Halal et al. Fixed bulk or annular tissue research heat transfer;And William G and D.E.Fleischer et al. pass through sacculus point using radio frequency The treatment of the disease such as Ventricular Tachycardia and Ba Leiteshi oesophaguses has not been carried out, and this radio frequency sacculus is not suitable for targetedly Atherosclerotic blood vessel internal therapentics;Anderson et al. has considered the factors such as blood vessel, for tumour ermal physics Treatment gives a new scheme, but its scheme model is still established on the basis of large-scale lumps tumour, is not accounted for The parameters such as thermal conductivity factor can be affected by temperature.Conventional ermal physics mode is mainly used in deep tissue as can be seen here, such as The penetration effect heating tumor mass of deep tissue is treated using radio frequency etc..

Swash the essential therapeutic arsenals that optical and radio fequency sacculus is current atherosclerosis disease ermal physics treatment. Geschwind, Ginsburg, Choy and Cumberland etc. are respectively clinically using the spot in laser probe ablation vessels Block, get through the blood vessel of occlusion.Decker and Christensen etc. establish laser heating blood vessel conducting heat model, and with reality Data are tested to compare.

In addition to laser heats blood vessel, Becker etc. is that the blood vessel dilatation art for solving common sacculus treats vascular lesion position Afterwards the middle film and inner membrance of caused blood vessel can mutual stripping problem, be bonded whole piece radio frequency electrical in Common radio frequency balloon surface Pole, treated using radio-frequency energy heats vascular wall, and then to vascular lesion position, this treatment method has used whole ball Capsule surface carries out heating ablation as radio-frequency electrode, so as to be extremely difficult to that conformal targeting is carried out for different size lesions Treatment.Fram etc. in view of radio-frequency electrode is placed on balloon surface and not easily passs through percutaneous surgery conveys lesion locations by sacculus, and Catheter shaft in sacculus arranges radio-frequency electrode, and correspondingly arranges that one group of thermocouple is used for measuring ball near radio-frequency electrode Intracapsular temperature, and physiological saline is filled in radio frequency sacculus, by way of heat transfer, increase is delivered to the heat of vascular wall Amount, this mode employs physiological saline and causes the balloon surface of fixed dimension to be in thermally equivalent, but same heating region is All influence areas of surrounding electric poles, the conformal therapy to different size patches can not be accomplished.

In summary, there is an urgent need to the atherosclerosis guiding target treatment device with better healing effect for this area

The content of the invention

The purpose that the present invention carries just is to provide a kind of atherosclerosis guiding target treatment device, has to atherosclerosis The effect of more preferable.

In the first aspect of the invention, there is provided a kind of atherosclerosis guiding target treatment device, including it is at least one Sacculus and treatment control system are treated, wherein

The outer surface for the treatment of sacculus is provided with multiple radio frequency microelectrode arrays and temperature sensor that can work independently, and treats The cold medium peripheral passage being internally provided with for accommodating and circulating cold medium of sacculus, and

Treatment control system includes cold medium loop control module and RF therapy control module, cold medium loop control mould Block is connected to cold medium peripheral passage by control output end mouth, and RF therapy control module includes radio frequency selection circuit and radio frequency Output port, the micro- electricity for the treatment of radio frequency that RF therapy control module selects to connect on radio frequency output port by radio frequency selection circuit Pole;And

Treat the cold medium that control system is used to control by cold medium loop control module in cold medium peripheral passage Flow velocity, to adjust temperature, and the output signal of each radio frequency output port is controlled by RF therapy control module, it is exported Signal can be the same or different, so that radio frequency microelectrode may be at different on off states and different rf frequencies.

In another preference, output signal refers to the switch controlling signal and rf frequency selection control letter of radio frequency microelectrode Number.

In another preference, treatment control system also include main control module, main control module comprising touch screen and The microcontroller of the touch screen is connected to, main control module selects the corresponding micro- electricity of radio frequency according to size, the shape of atheromatous plaque Conformal targeted therapy, while the power of feedback treating, treatment energy and real-time treatment temperature are extremely carried out to it, according to feedback Treatment power, the corresponding RF therapy control module output radiofrequency signal of energy, temperature control and control respective radio-frequency micro- Electrode works and control cold medium loop module work, so as to reach treatment to atherosclerotic plaque and to blood vessel endothelium Protective effect.

In another preference, treatment control system also includes the RF therapy control module being connected with main control module, For according to the control signal from main control module, on off state and the selection of radio frequency microelectrode to be controlled by radio frequency output port The rf frequency for the treatment of, RF therapy control module include radio frequency frequency selection circuit, and circuit, radio frequency control output occur for radio-frequency power supply Circuit and radio frequency output interface.

In another preference, each radio frequency output port is one-to-one or one-to-many with each radio frequency microelectrode respectively Or many-one connect.

In another preference, treatment control system also includes Feedback of Power circuit, and cold medium circulating controling circuit, Wherein,

Feedback of Power circuit respectively with radio frequency output port, and microcontroller connect, for microcontroller feedback from The power parameter and energy parameter of each radio frequency microelectrode of radio frequency output port collection;

Cold medium circulating controling circuit is connected with microcontroller and cold medium peripheral passage respectively, for according to microcontroller Control signal determined by power parameter, energy parameter, real time temperature of the device from radio frequency microelectrode, is controlled by SAPMAC method medium The flow velocity of cold medium in port controlling cold medium peripheral passage, to adjust temperature, wherein cold medium can be by being back to body Outside, or by the another port of sacculus flow into blood vessel.

In another preference, radio frequency microelectrode is burnt at the surface for the treatment of sacculus in the form of multiple electrodes array.

In another preference, the temperature range of cold medium is -20 DEG C -37 DEG C.

In another preference, the area of each radio frequency microelectrode is identical, or different, and areal extent is 0.01mm2Extremely 1000mm2

In another preference, the operating frequency range of radio frequency microelectrode is optional between 200KHz-200MHz.

In another preference, main control module uses the microprocessor of 32 bit DSPs.

In another preference, comprising at least one treatment sacculus, each radio frequency output port is penetrated with each respectively Frequency microelectrode connects one to one.

In another preference, radio frequency microelectrode is burnt at balloon surface and supravasal micro- electricity by specific process technology Polar conductor is drawn, and then by flexible cable access control system, forms treatment control access.

In another preference, main control module can select corresponding radio frequency micro- according to size, the shape of atheromatous plaque It carries out conformal targeted therapy, while the power and treatment energy of feedback treating to electrode pair, according to the treatment power of feedback with The corresponding RF therapy control module of energy hole exports radiofrequency signal and controls respective radio-frequency microelectrode to work and control Cold medium loop module works, protective effect while so as to reach the treatment to atherosclerotic plaque to blood vessel endothelium.

In another preference, balloon surface the radio frequency microelectrode arrays of multiple particular size specifications is distributed with, be used for According to the corresponding plaque of conformal therapy, and small temperature sensor, for gathering the temperature in therapeutic process in real time Information, also, balloon interior may be equipped with cold medium peripheral passage and be used to protect vascular endothelial tissue, described particular size The radio frequency microelectrode size of specification is in 0.01mm2-1000mm2Between;Here the temperature of cold medium is at -20 DEG C -37 Associated media between DEG C.

In another preference, balloon surface radio frequency microelectrode can be separate when working, and by being burnt at The wire on balloon surface and foley's tube surface is drawn out to the end of foley's tube, then passes through Aviation Connector using flexible cable Access radio frequency and circuit occurs.

In another preference, system can select corresponding conformal radio frequency micro- according to the size, size, shape of vascular plaque Electrode combination, to reach targeted therapy purpose.

In another preference, control module carries radio frequency frequency selection circuit, can be penetrated accordingly according to treatment actual selection Frequency therapeutic frequency, to reach the penetration depth requirement to the treatment of different depth patch;Here radio frequency selection circuit is selectable RF therapy frequency is the frequency between 200KHz-200MHz.

In another preference, the governor circuit of device employs the microprocessor of 32 bit DSPs as master controller, to whole Individual apparatus system carries out programmed therapy control, and the realization for the treatment of algorithm.

In another preference, described device carries out system control using touch screen and shown with visualization, during treatment Selection is opened corresponding therapeutic electrode and treated on screen, and so as to reach targetedly targeted therapy, and real-time display is controlled Corresponding treatment parameter during treatment.

In another preference, the device and system of atherosclerosis targeted therapy of the invention, the therapeutic system Including master control system and targeted therapy sacculus, described treatment balloon surface, which is distributed with, multiple applies treatment of atherosclerosis Radio frequency microelectrode and temperature sensor, and blood vessel endothelium is carried out during for treating real-time guard cold medium circulate it is logical Road.Described master control system includes microprocessor control circuit, touch display circuit, radio frequency and circuit, electrode selection occurs Circuit, cold medium circulating controling circuit;The control system is according to size, size, depth of actual atheromatous plaque to be treated etc. Information, the corresponding conformal radio frequency microelectrode of selection, so as to coordination electrode selection circuit, opens radio frequency microelectrode corresponding to sacculus; It is simultaneously corresponding over the course for the treatment of open, the regulation cold medium circulatory system with real-time guard blood vessel endothelium over the course for the treatment of not It is damaged;And Real-time Feedback treats power and the relevant parameter for the treatment of energy over the course for the treatment of, then system is according to treatment During relevant parameter controlled system with self-regulation the course of work, to realize the targeted therapy of atherosclerosis.

In another preference, the information such as the size of the atherosclerotic plaque in the therapeutic process, size, depth Determination, employ advanced Angiography technology, small blood vessel imaging probe goed deep into internal blood vessel, carried out real-time Internal blood vessel imaging and navigation.

Also include radio-frequency power supply in another preference, in the therapeutic system and module, its therapeutic process occurs with radio frequency In mainly by Programmed control adjust radio frequency source power with reach to corresponding atheromatous plaque ablation with treat purpose.

In another preference, the radio frequency occurs in the design of circuit, has used the radio frequency matching network of multi-frequency Circuit, to reach the requirement for adapting to the atheromatous plaque of different size, size and depth and treating.

In another preference, the cold medium circulatory system, the circulation of described cold medium are further comprises in the therapeutic system System, by main control circuit according to corresponding treatment parameter in therapeutic process, cold medium circulating controling circuit is controlled, so as to control Cold medium flow velocity in the cold medium circulatory system, it is intravascular to treating so as to play to reach the cooling to treating blood vessel endothelium The protective effect of skin.

In another preference, employed in the therapeutic system resistance type touch control screen carry out system control set with it is visual Change man-machine interaction to show.Described resistance type touch control screen is mainly used in setting treatment parameter over the course for the treatment of, lower transmission control system ginseng The information such as associated treatment parameter in number and corresponding control command information, and real-time display therapeutic process;Described touch screen enters Row system controls, and it uses having the advantage that for touch screens easily to carry out operational control over the course for the treatment of.

In another preference, the treatment sacculus in the treatment system, sacculus is goed deep into internal blood vessel before treatment, Then sacculus is enabled to expand using internally saline injection or other associated medias, so as to prop up blood vessel to be treated, So that the treatment microelectrode of balloon surface fully contacts with patch to be treated, so as to reach the purpose of targeted therapy;And sacculus Inside carry cold medium circulation canal, for while radio frequency heating is treated to the cooling down of blood vessel endothelium, to protect blood Endothelial tube tissue is injury-free.

In another preference, described electrode control circuit, mainly microprocessor are sent out according to specific treatment algorithm Go out corresponding control signal, then conformal radio frequency microelectrode corresponding to control, so as to realize the selection to sacculus radio frequency microelectrode Property open, to reach the purpose of conformal targeted therapy.

In another preference, described radio frequency sacculus microelectrode employs specific micro-fluidic process technology, will be specific The electrode of size according to certain specification arranged in balloon surface, then by the wire and foley's tube of balloon surface Radio-frequency power supply interface is accessed by flexible cable after electrode cable extraction, realizes treatment path.

The beneficial effects of the present invention are:Complexity is low, easy to operate, efficiency high, can realize according to Atherosclerosis Change the actual conditions of patch, targeted therapy corresponding to progress.

It should be understood that within the scope of the present invention, above-mentioned each technical characteristic of the invention and have in below (eg embodiment) It can be combined with each other between each technical characteristic of body description, so as to form new or preferable technical scheme.As space is limited, exist This no longer tires out one by one states.

Brief description of the drawings

Fig. 1 is the connection structure diagram of atherosclerosis guiding target treatment device of the present invention;

Fig. 2 is the balloon structure schematic diagram of the preferred embodiment of the present invention;

Fig. 3 is that microelectrode heating changes over time tendency chart in Temperature Distribution caused by expandable prosthetic;

Fig. 4 is influence schematic diagram of the different radio frequency number of electrodes to tissue heating efficiency;

Fig. 5 is 3D temperature profile of the different radio frequency number of electrodes to tissue heating;

Fig. 6 be in sacculus different temperatures cooling water to the influence schematic diagram of radio frequency sacculus heating efficiency;

Fig. 7 is the 3D distribution maps of the lower sacculus heating-up temperature of different temperatures cooling water effect in sacculus.

In the drawings, A:Treat control system, B:Power supply, C:The cold medium circulatory system, D:Flexible cable, E:Ball Capsule, A1:Microcontroller, A2:Touch control display module, A3:Rf frequency selection circuit, A4:Circuit, A5 occur for radio frequency:Electrode is opened Close selection circuit, A6:Power/energy feedback circuit, A7:Radio frequency interface, A8:Cold medium circulating controling circuit, E1:The micro- electricity of radio frequency Pole, E2:Foley's tube, E3:Sacculus.

Embodiment

The present inventor has taken into full account the pass of radio frequency sacculus treatment temperature and treatment time by in-depth study extensively Fasten, employ the model of ermal physics treatment, it is contemplated that the relation of radio-frequency electromagnetic transmission in the tissue and temperature, probe into not With the Temperature Distribution of vascular wall at a temperature of radiofrequency field and balloon surface, and different frequency radiofrequency signal is taken full advantage of to tissue Penetration capacity, devise a kind of atherosclerosis guiding target treatment device and athero- hard for different size, sized arteries Change the treatment sacculus that patch carries out conformal therapy, effectively to carry out targeted therapy to atherosclerotic plaque.

Term

As used herein, term " microprocessor ", " microcontroller " are used interchangeably.

As used herein, term " radio frequency microelectrode switch selection circuit ", " electrode switch selection circuit " are used interchangeably.

As used herein, term " sacculus ", " treatment sacculus " are used interchangeably.

As used herein, term " cold medium circulating controling circuit ", " SAPMAC method control module " are used interchangeably.

As used herein, term " touch screen ", " touch control display module " are used interchangeably.

As used herein, term " main control module ", " master controller " are used interchangeably.

As used herein, term " radio frequency interface ", " radio frequency output port " are used interchangeably.

Device is always broadly described

In the first aspect of the invention, there is provided a kind of atherosclerosis guiding target treatment device, including it is at least one Sacculus and treatment control system are treated, wherein

The outer surface for the treatment of sacculus is provided with multiple radio frequency microelectrode arrays and temperature sensor that can work independently, and treats The cold medium peripheral passage being internally provided with for accommodating and circulating cold medium of sacculus, and

Treatment control system includes cold medium loop control module and RF therapy control module, cold medium loop control mould Block is connected to cold medium peripheral passage by control output end mouth, and RF therapy control module includes radio frequency selection circuit and radio frequency Output port, the radio frequency microelectrode that RF therapy control module selects to connect on radio frequency output port by radio frequency selection circuit; And

Treat the cold medium that control system is used to control by cold medium loop control module in cold medium peripheral passage Flow velocity, to adjust temperature, and the output signal of each radio frequency output port is controlled by RF therapy control module, it is exported Signal can be the same or different, so that radio frequency microelectrode may be at different on off states and different rf frequencies.

In another preference, output signal refers to the switch controlling signal and rf frequency selection control letter of radio frequency microelectrode Number.

In another preference, treatment control system also include main control module, main control module comprising touch screen and Be connected to the microcontroller of the touch screen, main control module select corresponding radio frequency micro- according to the size of atheromatous plaque, shape It carries out conformal targeted therapy, while the power and treatment energy of feedback treating to electrode pair, and gathers in therapeutic process Real time temperature, radio frequency is exported according to the real time temperature of feedback, treatment power RF therapy control module corresponding with energy hole Signal and respective radio-frequency microelectrode is controlled to work and control cold medium loop module work, so as to reach to atherosis spot The treatment of block and the protective effect to blood vessel endothelium.

In another preference, treatment control system also includes the RF therapy control module being connected with main control module, For according to the control signal from main control module, on off state and the selection of radio frequency microelectrode to be controlled by radio frequency output port The rf frequency for the treatment of, RF therapy control module include radio frequency frequency selection circuit, and circuit, radio frequency control output occur for radio-frequency power supply Circuit and radio frequency output interface.

In another preference, each radio frequency output port is one-to-one or one-to-many with each radio frequency microelectrode respectively Or many-one connect.

In another preference, treatment control system also includes Feedback of Power circuit, and cold medium circulating controling circuit, Wherein, Feedback of Power circuit connects with radio frequency output port, and microcontroller respectively, for being fed back to microcontroller from radio frequency The power parameter and energy parameter of each radio frequency microelectrode of output port collection;

Cold medium circulating controling circuit is connected with microcontroller and cold medium peripheral passage respectively, for according to microcontroller Control signal determined by power parameter and energy parameter of the device from radio frequency microelectrode, controlled by SAPMAC method medium control port The flow velocity of cold medium in cold medium peripheral passage, to adjust temperature.

In another preference, radio frequency microelectrode is evenly provided on the surface for the treatment of sacculus.

In another preference, temperature sensor is also distributed with radio frequency balloon surface.

In another preference, the temperature range of cold medium is -20 DEG C -37 DEG C.

In another preference, the area of each radio frequency microelectrode is identical, or different, and areal extent is 0.01mm2Extremely 1000mm2

In another preference, the operating frequency range of radio frequency microelectrode is optional between 200KHz-200MHz.

In another preference, main control module uses the microprocessor of 32 bit DSPs.

It is micro- with each radio frequency respectively comprising three treatment sacculus, each radio frequency output port in another preference Electrode connects one to one.

In another preference, radio frequency microelectrode is burnt at balloon surface and supravasal micro- electricity by specific process technology Polar conductor is drawn, and then by flexible cable access control system, forms treatment control access.

In another preference, main control module can select corresponding radio frequency micro- according to size, the shape of atheromatous plaque It carries out conformal targeted therapy, while the power and treatment energy of feedback treating to electrode pair, according to the treatment power of feedback with The corresponding RF therapy control module of energy hole exports radiofrequency signal and controls respective radio-frequency microelectrode to work and control Cold medium loop module works, so as to reach the treatment to atherosclerotic plaque and the protective effect to blood vessel endothelium.

In another preference, balloon surface the radio frequency microelectrode arrays of multiple particular size specifications is distributed with, be used for According to the corresponding plaque of conformal therapy, also, balloon interior may be equipped with cold medium peripheral passage and be used to protect blood vessel Endothelial tissue, particular size specification radio frequency microelectrode size in 0.01mm2-1000mm2Between;Here cold Associated media of the temperature of medium between -20 DEG C -37 DEG C.

In another preference, balloon surface radio frequency microelectrode can be separate when working, and by being burnt at The wire on balloon surface and foley's tube surface is drawn out to the end of foley's tube, then passes through Aviation Connector using flexible cable Access radio frequency and circuit occurs.

In another preference, it is accordingly conformal radio frequency that system can select according to the size, size, shape of vascular plaque Microelectrode, to reach targeted therapy purpose.

In another preference, control module carries radio frequency frequency selection circuit, can be penetrated accordingly according to treatment actual selection Frequency therapeutic frequency, to reach the penetration depth requirement to the treatment of different depth patch;Here radio frequency selection circuit is selectable RF therapy frequency is the frequency between 200KHz-200MHz.

In another preference, the governor circuit of device employs the microprocessor of 32 bit DSPs as master controller, to whole Individual apparatus system carries out programmed therapy control, and the realization for the treatment of algorithm.

In another preference, device system control carried out using touch screen shown with visualization, in screen during treatment Upper selection is opened corresponding therapeutic electrode and treated, and so as to reach targetedly targeted therapy, and real-time display was treated Corresponding treatment parameter in journey.

It is another object of the present invention to provide a kind of device and system for atherosclerosis targeted therapy, institute Stating therapeutic system includes master control system and targeted therapy sacculus, and described treatment balloon surface is uniformly distributed athero- using artery Conformal the radio frequency microelectrode and temperature sensor of hardening, and the SAPMAC method of real-time guard is carried out during for treating to blood vessel endothelium Path.Described master control system includes microprocessor control circuit, touch display circuit, radio frequency and circuit, electrode choosing occurs Select circuit, SAPMAC method control circuit;The control system is according to letters such as the sizes, size, depth of actual atheromatous plaque to be treated Breath, corresponding conformal radio frequency microelectrode is selected, so as to coordination electrode selection circuit, open radio frequency microelectrode corresponding to sacculus;Together When over the course for the treatment of accordingly open, adjust SAPMAC method system be not damaged over the course for the treatment of with real-time guard blood vessel endothelium Wound;And Real-time Feedback treats power and the relevant parameter for the treatment of energy over the course for the treatment of, then system is according to therapeutic process In relevant parameter regulation and control system the course of work, to realize the targeted therapy of atherosclerosis.

Preferably, the determination of the information such as the size of the atherosclerotic plaque in the therapeutic process, size, depth, Advanced Angiography technology is employed, small blood vessel imaging probe is goed deep into internal blood vessel, carries out real-time blood vessel Internal imaging and navigation.

Further, radio-frequency power supply and radio frequency are also included in the therapeutic system and occurs module, it is main in its therapeutic process It is that purpose of the power of radio frequency source to reach the ablation to corresponding atheromatous plaque with treat is adjusted by Programmed control.

Further, the radio frequency occurs in the design of circuit, has used the radio frequency matching network circuit of multi-frequency, with Reach the requirement for the atheromatous plaque treatment for adapting to different size, size and depth.

Further, the cold medium circulatory system is further comprises in the therapeutic system, the described cold medium circulatory system, is led to Main control circuit is crossed according to corresponding treatment parameter in therapeutic process, SAPMAC method control circuit is controlled, so as to control cooling cycle system In cold medium flow velocity, with reach to treat blood vessel endothelium cooling, so as to play to treat blood vessel endothelium protective effect.

Further, resistance type touch control screen progress system control is employed in the therapeutic system to set and visualize man-machine Interaction display.Described resistance type touch control screen is mainly used in setting treatment parameter over the course for the treatment of, lower biography control parameter and phase Answer the information such as associated treatment parameter in control command information, and real-time display therapeutic process;Described touch screen carries out system Control, it uses having the advantage that for touch screens easily to carry out operational control over the course for the treatment of.

Further, the treatment sacculus in the treatment system, gos deep into internal blood vessel by sacculus before treatment, then makes Sacculus is enabled to expand with internally saline injection or particular medium, so as to prop up blood vessel to be treated so that sacculus table The treatment microelectrode in face fully contacts with patch to be treated, so as to reach the purpose of targeted therapy;And balloon interior is with cold Medium circulation passage, for while radio frequency heating is treated to the cooling down of blood vessel endothelium, to protect vascular endothelial tissue It is injury-free.

Further, described electrode control circuit, mainly microprocessor are sent accordingly according to specific treatment algorithm Control signal, then control corresponding to conformal radio frequency microelectrode, sacculus radio frequency microelectrode is selectively unlocked so as to realize, To reach the purpose of conformal targeted therapy.

Further, described radio frequency sacculus microelectrode employs specific micro-fluidic process technology, by specific dimensions Electrode in balloon surface, is then led according to certain specification arranged by the electrode on the wire and foley's tube of balloon surface Radio-frequency power supply interface is accessed by flexible cable after line extraction, realizes treatment path.

Main advantages of the present invention include:

1) it is easy to operate;

2) complexity of design is low;

3) significantly more efficient conformal targeted therapy can be carried out to different size atherosclerosis plate.

4) protection while treatment of atherosclerosis can be realized to endothelial tissue.

With reference to specific embodiment, the present invention is expanded on further.It should be understood that these embodiments are merely to illustrate the present invention Rather than limitation the scope of the present invention.The experimental method of unreceipted actual conditions in the following example, generally according to conventional strip Part or according to the condition proposed by manufacturer.Unless otherwise indicated, otherwise percentage and number are percentage by weight and weight Number.

Embodiment 1:Atherosclerosis guiding target treatment device No.1

The connection figure of the present embodiment atherosclerosis guiding target treatment device is referring to Fig. 1, described device is mainly profit Concrete condition with atherosclerosis targeted therapy control system according to atheromatous plaque, control the radiofrequency signals of corresponding frequencies with The conformal radio frequency microelectrode on sacculus is opened, so as to reach the therapeutic action to atherosclerotic plaque.

Structure

Shown in accompanying drawing 1, described device includes treatment control system A, power supply B, cold medium circulatory system C, flexible electrical Cable D, balloon-system E, wherein, treatment control system is by microcontroller A1, touch control display module A2, rf frequency selection circuit A3, radio frequency occur circuit A4, electrode switch selection circuit A5, power/energy feedback circuit A6, radio frequency interface A7, cold medium and followed Loop control circuit A8 etc. is formed.

Wherein, circuit A4 occurs for rf frequency selection circuit A3, radio frequency, electrode switch selection circuit A5 constitutes above-mentioned penetrate Frequency treatment control module.Microcontroller A1, touch control display module A2 constitute above-mentioned main control module.

As shown in Fig. 2 treatment radio frequency microelectrode E1 is distributed with according to specific standard requirement on sacculus E3, described radio frequency is micro- Electrode E1 is to be burnt at balloon surface by specific process technology to draw with supravasal microelectrode lead, then passes through flexible electrical Cable D access treatment control system A, form treatment control access.

As shown in figure 1, the treatment control system A of the atherosclerosis guiding target treatment device of the present embodiment is mainly used for The power conformal radio frequency microelectrode corresponding to energy and selection of radio frequency, and the control cold medium circulatory system are controlled, so as to reach To the targeted therapy of atherosclerotic plaque.

Operation principle

In the course of work of the atherosclerosis guiding target treatment device of the present embodiment, according to the shape of corresponding patch, Volume, size, by conformal radio frequency microelectrode E3 corresponding to touch screen A2 selections, and selection respective radio-frequency frequency (selection Frequency is according to specific Therapeutic selection, frequency range 230KHz~20MHz), and treatment parameter is set (such as treatment work( Rate, treatment energy, the frequency of selection, therapeutic electrode selection, treatment temperature), then issue an order and give microprocessor A1, make its control With radio frequency the corresponding radiofrequency signal of circuit A4 generations, and control microelectrode switch selection occur for rf frequency selection circuit A3 processed Circuit A5, corresponding electrod-array, while power and energy in Real-time Feedback therapeutic process are opened, then controlling according to feedback Cold Jie of circuit A4 and cold medium circulating controling circuit A8 controls occurs for the further adjustment control radio frequency of parameter for treating power and energy Matter circulatory system C, so as to reach the treatment to atheromatous plaque and the protective effect of blood vessel endothelium.

As shown in figure 1, the cold medium circulatory system C of the atherosclerosis guiding target treatment device mainly passes through treatment Control system A sends modulated signal, controls the rotating speed of peristaltic pump, intravascular to treating so as to reach to control cold medium flow velocity The cooling protection effect of skin.

Radio frequency microelectrode E1

As shown in Fig. 2 described atherosclerosis targeted therapy balloon-system E, mainly includes sacculus E3, radio frequency is micro- Electrode array E 1, foley's tube E2 etc., radio frequency microelectrode array E1 is to employ specific processing technology, according to certain specification Arrangement, be burnt on treatment radio frequency sacculus, and the work of each microelectrode be it is separate, over the course for the treatment of can root Targeting conformal therapy is carried out according to sacculus microelectrode corresponding to the selection of corresponding Patch size.

Radio frequency microelectrode array E1 is mainly to be drawn by the wire on sacculus E3 surfaces and conduit E2 surfaces, then, Treatment control system A is accessed by flexible cable D, treatment path is formed, the cold medium circulatory system is carried inside foley's tube E2, For, so as to adjust the temperature of balloon surface, can be reached by adjusting the flow velocity of the cold medium circulatory system over the course for the treatment of The temperature of blood vessel endothelium is reduced, so as to ensure that therapeutic process Vascular Endothelial is injury-free.

Embodiment 2:Atherosclerosis guiding target treatment device No.2

The connection figure of the present embodiment atherosclerosis guiding target treatment device is referring to Fig. 1, described device is mainly profit Concrete condition with atherosclerosis targeted therapy control system according to atheromatous plaque, control the radiofrequency signals of corresponding frequencies with The conformal radio frequency microelectrode on sacculus is opened, so as to reach the therapeutic action to atherosclerotic plaque.Described device includes Treat control system A, power supply B, cold medium circulatory system C, flexible cable D, sacculus E, wherein, treatment control system be by Circuit A4, electrode switch selection circuit occur for microcontroller A1, touch control display module A2, rf frequency selection circuit A3, radio frequency A5, power/energy feedback circuit A6, radio frequency interface A7, cold medium circulating controling circuit A8 etc. are formed, and wherein A3, A4, A5 are formed RF therapy control described above.Treatment radio frequency microelectrode is distributed with according to specific standard requirement on described sacculus E, it is described Radio frequency microelectrode be to be burnt at balloon surface and supravasal microelectrode lead by specific process technology to draw, then pass through Flexible cable D access control systems, form treatment control access.

As shown in figure 1, the treatment control system A of the atherosclerosis guiding target treatment device is mainly used for control and penetrated The power of frequency conformal radio frequency microelectrode corresponding to energy and selection, and the control cold medium circulatory system, so as to reach to artery The targeted therapy of atherosclerotic plaque.It according to the shape, volume, size of corresponding patch, passes through touch screen in the course of the work Conformal radio frequency microelectrode corresponding to A2 selections, and selection respective radio-frequency frequency, and treatment parameter is set, then issue an order It is set to control rf frequency selection circuit A3 that the corresponding radiofrequency signal of circuit A4 generations occurs with radio frequency to microprocessor A1, and Microelectrode switch selection circuit A5 is controlled, opens corresponding electrod-array, while power and energy in Real-time Feedback therapeutic process Amount, circuit A4 is then occurred according to the further adjustment control radio frequency of parameter of the treatment power and energy of feedback and circulated with cold medium Control circuit A8 controls the cold medium circulatory system, so as to reach the treatment to atheromatous plaque and the protective effect of blood vessel endothelium.

As shown in figure 1, the cold medium circulatory system C of the atherosclerosis guiding target treatment device mainly passes through control System sends modulated signal, controls the rotating speed of peristaltic pump, to control cold medium flow velocity, so as to reach the drop to treating blood vessel endothelium Warm protective effect, wherein cold medium can be external by being back to, or are flowed into by the another port of sacculus in blood vessel.

As shown in Fig. 2 described atherosclerosis targeted therapy sacculus E, mainly includes sacculus E3, radio frequency microelectrode Array E1, foley's tube E2 etc., described radio frequency microelectrode E1 is to employ specific processing technology, is arranged according to certain specification Cloth, be burnt on treatment radio frequency sacculus, and the work of each microelectrode be it is separate, over the course for the treatment of can basis Sacculus microelectrode corresponding to corresponding Patch size selection carries out targeting conformal therapy;Described electrode mainly passes through sacculus table Wire on face and catheter surface is drawn, and then, is being accessed instrument by flexible cable, is being formed treatment path, described sacculus Catheter interior carries the cold medium circulatory system, for over the course for the treatment of can by adjusting the flow velocity of the cold medium circulatory system, So as to adjust the temperature of balloon surface, the temperature for reducing blood vessel endothelium is reached, so as to ensure that therapeutic process Vascular Endothelial It is injury-free.

Embodiment 3:Atherosclerosis guiding target treatment device No.3

A kind of atherosclerosis guiding target treatment device, described device include:Control system is treated, power supply is cold to follow Loop system, flexible cable, treat sacculus;Described treatment control system includes microcontroller, touch control display module, rf frequency Circuit, electrode switch selection circuit, power/energy feedback circuit, radio frequency interface, cold medium circulation occur for selection circuit, radio frequency Control circuit etc..

Described treatment sacculus in the course of the work, is deep into internal blood vessel to be treated, then injects and gives birth to balloon interior Salt solution is managed, so as to be that whole sacculus is in and props up state, and then enables the electrode on sacculus effectively to touch treatment blood Pipe patch is treated.

Described treatment control system mainly controls radio frequency that circuit occurs, and radio frequency microelectrode switch selection circuit is to sacculus On corresponding treatment electrode send radiofrequency signal, with the treatment to atherosclerotic plaque, at the same therapeutic process control it is cold Cooling processing of the medium circulation system to blood vessel endothelium, is unlikely to because for the treatment of so as to reach the protection of therapeutic process Vascular Endothelial And damage, and over the course for the treatment of can Real-time Feedback treat parameter accordingly, for the feedback parameter in therapeutic process with The output of regulation circuit in real time.And real-time display it can treat information on touch screen.

Present invention is disclosed a kind of atherosclerosis guiding target treatment device, the specific implementation of described therapeutic system is included such as Lower step:

Step S1:Real time imagery and navigation are carried out using Angiography technology in the present invention, observation measurement is to be treated The information such as the size of vascular plaque, size, depth, according to the information of detection, judge therapeutic scheme, are treated.

Step S2:By the sacculus for not being filled with liquid according to angiographic imaging information navigation, it is intravascular to be deep into treatment Portion, after reaching relevant position, to treatment balloon interior saline injection or associated media, prop up it so that sacculus Internal electrode can be adequately exposed to treat patch, to reach the purpose for the treatment of

Step S3:The blood vessel specifying information fed back according to imaging system in art, judge to open the corresponding conformal micro- electricity of radio frequency Pole, and select corresponding therapeutic frequency to reach effective treatment;Then, relevant work electrode is selected with penetrating by touch screen Frequent rate, promote microprocessor control related circuit work, reach the treatment to atherosclerotic plaque.

Step S4:Over the course for the treatment of, collection balloon surface temperature, treatment power are related to treatment energy etc. in real time joins Number, then system control the co-ordination of whole system according to relevant parameter as feedback adjustment signal, and in therapeutic process Control the flow velocity of the cold medium circulatory system.With the cooling to endangium, so as to play the protective effect to endangium.

The beneficial effects of the present invention are do not disclose controlling for a kind of atherosclerosis guiding target treatment device and system tightly Treatment method, while also used the invention device bionical thing tissue glue to carry out simulation treatment test, used in test process Thermal infrared imager for FLIR companies of the U.S. produce (FLIR Systems, Inc.Wilsonville, US) treated in real time The distribution tests in temperature field.Microelectrode heating is tested respectively changes over time tendency chart in Temperature Distribution caused by expandable prosthetic Such as Fig. 3 (heating time period of every width figure is 20s);Different radio frequency number of electrodes (six electrodes and five electrodes) heats energy to tissue The influence of power such as Fig. 4 is (left:Six electrodes, it is right:Five electrodes), 3D Temperature Distributions such as Fig. 5 caused by its correspondence;And contrast test Identical electrodes balloon interior added by cooling water circulation passageway 16 DEG C, 12 DEG C, after 35 DEG C of aqueous water treatment 50s, control Treat the temperature field of tissue inner membrance and thermo parameters method such as Fig. 6 (left sides for the treatment of tissue:16 DEG C of cooling waters are passed through, in:Be passed through 12 DEG C it is cold But water, it is right:It is passed through 35 DEG C of the aqueous water close with body temperature), 3D Temperature Distributions such as Fig. 7 caused by its correspondence.

In summary, a kind of atherosclerosis guiding target treatment device provided by the invention, one kind is not only provided and is applied to The instrument and equipment of the treatment of atherosclerosis, also provide therapeutic process in treatment method, simultaneously for its principle can Row is tested.It is one simple to operation, high efficiency, the treatment medical instrument of low complex degree, can realizes selective The thorough treatment to atherosclerosis disease, and can over the course for the treatment of to effectively tissue protect, solve The associated treatment problem of atherosclerotic plaque.

In summary, a kind of atherosclerosis guiding target treatment device provided by the invention, one kind is not only provided and is applied to The instrument and equipment of the treatment of atherosclerosis, also provide therapeutic process in treatment method, simultaneously for its principle can Row is tested.It is one simple to operation, high efficiency, the treatment medical instrument of low complex degree, can realizes selective The thorough treatment to atherosclerosis disease, and can over the course for the treatment of to effectively tissue protect, solve The associated treatment problem of atherosclerotic plaque.

Test case

Applicant has used above-mentioned atherosclerosis guiding target treatment device bionical thing tissue glue to carry out simulation treatment and surveyed Examination, the thermal infrared imager used in test process for the production of FLIR companies of the U.S. (FLIR Systems, Inc.Wilsonville, US the distribution tests of real-time treatment temperature field) are carried out.

Microelectrode heating changes over time tendency chart such as Fig. 3 (heating of every width figure in Temperature Distribution caused by expandable prosthetic Time interval is 20s) shown in, propulsion over time, the effect of sacculus heating is more and more significant, and the temperature of expandable prosthetic rises It is also apparent from.

Differentiate with right side on the left of Fig. 4 under the conditions of being 6 radio frequency microelectrodes and 5 radio frequency microelectrodes, to organizing heating efficiency Influence, (heating region that different amounts of microelectrode can reach different).Also, Fig. 5 shows corresponding generation under above-mentioned condition 3D Temperature Distributions.The reduction of multi-pair electrodes temperature " point effect " so that the form deviation of the Temperature Distribution around multi-electrode In " area is big and peak value is small ".

Left, center, right in Fig. 6 are that identical radio frequency microelectrode is added in balloon interior by cooling water circulation passageway respectively 16 DEG C, 12 DEG C, after 35 DEG C of aqueous water treatment 50s, treat the temperature field of tissue inner membrance and the thermo parameters method for the treatment of tissue, (temperature of cooling medium influences very big on the Temperature Distribution of radio frequency expandable prosthetic in sacculus).Also, Fig. 7 shows above-mentioned condition 3D Temperature Distributions caused by lower correspondence, illustrate that influence of the balloon interior cooling medium to treatment results is most important.

All it is incorporated as referring in this application in all documents that the present invention refers to, it is independent just as each document It is incorporated as with reference to such.In addition, it is to be understood that after the above-mentioned instruction content of the present invention has been read, those skilled in the art can To be made various changes or modifications to the present invention, these equivalent form of values equally fall within the model that the application appended claims are limited Enclose.

Claims (9)

1. a kind of atherosclerosis guiding target treatment device, it is characterised in that controlled including at least one treatment sacculus and treatment System, wherein
The outer surface of the treatment sacculus is provided with multiple radio frequency microelectrode arrays and temperature sensor that can work independently, described The cold medium peripheral passage being internally provided with for accommodating and circulating cold medium of sacculus is treated, and
The treatment control system includes cold medium loop control module and RF therapy control module, the cold medium circulation control Molding block is connected to the cold medium peripheral passage by control output end mouth, and the RF therapy control module is selected comprising radio frequency Circuit and radio frequency output port are selected, the RF therapy control module opens the radio frequency by radio frequency selection circuit selection The radio frequency microelectrode combination connected on output port;And
The treatment control system is used to control in the cold medium peripheral passage by the cold medium loop control module The flow velocity of cold medium, to adjust temperature, and each described radio frequency output port is controlled by the RF therapy control module Output signal, its output signal is identical or different, so that the radio frequency microelectrode is in different on off states And different rf frequencies, so as to reach conformal targeted therapy purpose.
2. atherosclerosis guiding target treatment device as claimed in claim 1, it is characterised in that the output signal refers to described Switch controlling signal and rf frequency the selection control signal of radio frequency microelectrode.
3. atherosclerosis guiding target treatment device as claimed in claim 1, it is characterised in that the treatment control system is also Comprising main control module, the main control module includes touch screen and is connected to the microcontroller of the touch screen, described master Control module selects corresponding radio frequency microelectrode to carry out conformal targeted therapy to it according to size, the shape of atheromatous plaque, together When feedback treating power, treatment energy and treatment temperature, it is corresponding according to the treatment power, energy and temperature control of feedback RF therapy control module exports radiofrequency signal and controls respective radio-frequency microelectrode to work and control cold medium loop control Module works, so as to reach the treatment to atherosclerotic plaque and the protective effect to blood vessel endothelium.
4. atherosclerosis guiding target treatment device as claimed in claim 3, it is characterised in that the RF therapy controls mould Block is connected with main control module, for according to the control signal from the main control module, passing through the radio frequency output port The on off state of the radio frequency microelectrode and the rf frequency of selection treatment, the RF therapy control module is controlled to include radio frequency Circuit, radio frequency control output circuit and radio frequency output port occur for frequency selection circuit, radio-frequency power supply.
5. atherosclerosis guiding target treatment device as claimed in claim 1, it is characterised in that each described radio frequency output Port respectively with radio frequency microelectrode each described is one-to-one or one-to-many or many-one be connected.
6. atherosclerosis guiding target treatment device as claimed in claim 4, it is characterised in that the treatment control system is also Comprising Feedback of Power circuit, and cold medium circulating controling circuit, wherein,
The Feedback of Power circuit is connected with the radio frequency output port and the microcontroller respectively, for the micro-control The power parameter and energy parameter of each the radio frequency microelectrode of the device feedback processed from radio frequency output port collection;
The cold medium circulating controling circuit is connected with the microcontroller and the cold medium peripheral passage respectively, for root Believe according to being controlled determined by power parameter, energy parameter and real time temperature data of the microcontroller from the radio frequency microelectrode Number, by the flow velocity of the cold medium in cold medium peripheral passage described in cold medium loop control port controlling, to adjust temperature.
7. atherosclerosis guiding target treatment device as claimed in claim 1, it is characterised in that the temperature model of the cold medium Enclose is -20 DEG C -37 DEG C.
8. atherosclerosis guiding target treatment device as claimed in claim 1, it is characterised in that the micro- electricity of each radio frequency The area of pole is identical or different, and areal extent is 0.01mm2To 1000mm2
9. atherosclerosis guiding target treatment device as claimed in claim 1, it is characterised in that the work of the radio frequency microelectrode Working frequency scope is 200KHz-200MHz optional.
CN201610112668.4A 2016-02-29 2016-02-29 A kind of atherosclerosis guiding target treatment device CN105615998B (en)

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Citations (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6036689A (en) * 1998-09-24 2000-03-14 Tu; Lily Chen Ablation device for treating atherosclerotic tissues
CN1593353A (en) * 2004-06-17 2005-03-16 上海交通大学 Water-cooled radio frequency system for tumour extinguishing
CN1961987A (en) * 2005-11-08 2007-05-16 中国科学院理化技术研究所 Pole plate array heating device for general or local tumor thermotherapy
CN103068330A (en) * 2010-04-09 2013-04-24 Vessix血管股份有限公司 Power generating and control apparatus for the treatment of tissue
CN203400205U (en) * 2013-06-21 2014-01-22 深圳市君安康医疗器械有限公司 High-frequency tumor ablation system
CN103987336A (en) * 2011-09-14 2014-08-13 波士顿科学西美德公司 Ablation device with multiple ablation modes
CN104587598A (en) * 2015-01-29 2015-05-06 苏州长易电子科技有限公司 Non-invasive low-energy RF (Radio Frequency) diagnostic equipment
CN104783890A (en) * 2015-04-14 2015-07-22 上海交通大学 Melanoma cold and hot therapy device
CN204655099U (en) * 2015-04-14 2015-09-23 常承忠 A radio frequency melts electrode for treating freezing sacculus in area of high blood pressure

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6796980B2 (en) * 2001-11-21 2004-09-28 Cardiac Pacemakers, Inc. System and method for validating and troubleshooting ablation system set-up
CA2938411C (en) * 2003-09-12 2019-03-05 Minnow Medical, Llc Selectable eccentric remodeling and/or ablation of atherosclerotic material
US20120232549A1 (en) * 2011-03-09 2012-09-13 Vivant Medical, Inc. Systems for thermal-feedback-controlled rate of fluid flow to fluid-cooled antenna assembly and methods of directing energy to tissue using same

Patent Citations (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6036689A (en) * 1998-09-24 2000-03-14 Tu; Lily Chen Ablation device for treating atherosclerotic tissues
CN1593353A (en) * 2004-06-17 2005-03-16 上海交通大学 Water-cooled radio frequency system for tumour extinguishing
CN1961987A (en) * 2005-11-08 2007-05-16 中国科学院理化技术研究所 Pole plate array heating device for general or local tumor thermotherapy
CN103068330A (en) * 2010-04-09 2013-04-24 Vessix血管股份有限公司 Power generating and control apparatus for the treatment of tissue
CN103987336A (en) * 2011-09-14 2014-08-13 波士顿科学西美德公司 Ablation device with multiple ablation modes
CN203400205U (en) * 2013-06-21 2014-01-22 深圳市君安康医疗器械有限公司 High-frequency tumor ablation system
CN104587598A (en) * 2015-01-29 2015-05-06 苏州长易电子科技有限公司 Non-invasive low-energy RF (Radio Frequency) diagnostic equipment
CN104783890A (en) * 2015-04-14 2015-07-22 上海交通大学 Melanoma cold and hot therapy device
CN204655099U (en) * 2015-04-14 2015-09-23 常承忠 A radio frequency melts electrode for treating freezing sacculus in area of high blood pressure

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