CN110882445A

CN110882445A - Micro-drug delivery device

Info

Publication number: CN110882445A
Application number: CN201911264584.2A
Authority: CN
Inventors: 曹华; 秦建; 刘强
Original assignee: WUXI DINGDIAN MEDICAL DEVICE CO Ltd
Current assignee: WUXI DINGDIAN MEDICAL DEVICE CO Ltd
Priority date: 2019-12-11
Filing date: 2019-12-11
Publication date: 2020-03-17

Abstract

The invention discloses a micro-drug delivery device, which comprises a drug storage cavity and a first cavity, wherein the drug storage cavity and the first cavity are formed by separating a first piston; the micro-drug delivery device is characterized by further comprising a second cavity communicated to the first cavity in a one-way mode, damping media are filled in the first cavity and the second cavity, a driving damping mechanism is arranged on one side of the second cavity and drives the damping media in the second cavity to flow into the first cavity, and then the first piston is driven to move towards the drug storage cavity, so that micro-drug delivery is achieved. The micro-drug delivery device provided by the invention adopts a pure mechanical structure, has a simple structure and is low in manufacturing and using cost; and the micro-drug delivery device with a pure mechanical structure is safe and reliable to use.

Description

Micro-drug delivery device

Technical Field

The invention belongs to the field of drug infusion devices, and particularly relates to a micro-drug delivery device.

Background

Diabetes is a metabolic disease characterized by hyperglycemia. Some diabetics need to wear insulin infusion devices for treatment. An insulin pump is common in the wearable insulin infusion device at present. The large number and continued high speed increase of diabetics today, insulin pumps have many advantages, not requiring multiple daily injections; the dosage of insulin before meal is reduced, the overlapping effect of large dose of short-acting insulin and medium-acting insulin in the body after injection is avoided, and the occurrence of hypoglycemia is reduced. Insulin pumps are therefore accepted by an increasing number of diabetics.

Insulin pump manufacturers currently on the market are mainly force in Medtronics, Animas, instlet and ross in germany (Rothe), among others. However, the infusion drive systems of insulin pumps produced by these companies are mainly powered by miniature electric motors, which use a gear system to amplify the torque and eventually push the piston of the insulin cartridge to achieve the infusion of the drug. In addition, these insulin pumps typically comprise a reusable portion and a consumable portion (i.e., a non-reusable portion). This results in the need to continually replace disposable consumables during the use of the insulin pump, which increases the cost of the therapy. In addition, insulin pumps that rely on motors and electronics are susceptible to damage.

Disclosure of Invention

In order to solve the problems, the invention provides a micro-drug delivery device with a pure mechanical structure, which has simple structure and lower manufacturing and using cost, and is safe and reliable to use.

According to one aspect of the present invention, there is provided a micro drug delivery device for the delivery of a micro amount of a fluid drug, comprising a drug storage chamber and a first chamber body formed separated by a first piston. The drug storage cavity is connected with an infusion device. The micro-drug delivery device also comprises a second cavity communicated to the first cavity in a unidirectional way. Damping media are filled in the first cavity and the second cavity, a driving damping mechanism is arranged on one side of the second cavity and drives the damping media in the second cavity to flow into the first cavity, and then the first piston is driven to move towards the medicine storage cavity, so that micro-dose administration is realized. The micro-drug delivery device adopts a pure mechanical structure, has a simple structure and is low in manufacturing and using cost.

In some embodiments, the driving damping mechanism sequentially comprises an excitation switch, a pre-compressed elastic material and a second piston, the second piston is arranged at one end of the second cavity, the excitation switch is turned on, the pre-compressed elastic material transmits elastic pressure to the second piston, the second piston drives the damping medium in the second cavity to flow into the first cavity, and then the first piston is driven to move towards the medicine storage cavity, so that micro-dose administration is realized. The driving damping mechanism is in a pure mechanical structure, and is safe and reliable to use.

In some embodiments, the driving damping mechanism comprises a pressurizing member, an elastic material and a third piston in sequence, the third piston is arranged at one end of the second cavity, pressure is applied to the elastic material through the pressurizing member, the elastic material transmits the pressure to the third piston, and the third piston drives the damping medium in the second cavity to flow into the first cavity.

In some embodiments, the second cavity comprises a left cavity and a right cavity, the left cavity and the right cavity are respectively communicated with the first cavity in a unidirectional mode, and damping media are respectively filled in the left cavity and the right cavity; the driving damping mechanism comprises a first driving damping mechanism and a second driving damping mechanism, the first driving damping mechanism sequentially comprises an excitation switch, a pre-compressed elastic material and a second piston, the second piston is arranged at one end of the left cavity, the excitation switch is opened, the pre-compressed elastic material transmits elastic pressure to the second piston, and the second piston drives the damping medium in the left cavity to flow into the first cavity; the second driving damping mechanism comprises a pressurizing piece, an elastic material and a third piston in sequence, the third piston is arranged at one end of the right cavity, the pressurizing piece applies pressure to the elastic material, the elastic material transmits the pressure to the third piston, and the damping medium in the right cavity of the third piston is driven to flow into the first cavity. The drive damping mechanism adopts a pure mechanical structure, and is low in manufacturing and using cost.

In some embodiments, the pre-compressed resilient material is a pre-compressed spring.

In some embodiments, the resilient material is a spring.

In some embodiments, the activation switch is a push button switch, which is simple in construction, low in cost to manufacture and use, and mechanically safe and reliable to use.

In some embodiments, the pressure member is a pressure bar that abuts an end of the resilient material to facilitate the application of pressure to the resilient material.

In some embodiments, the second cavity is connected to the first cavity through a one-way check valve, which ensures one-way circulation of the damping medium.

In some embodiments, the left cavity and the right cavity are respectively connected with the first cavity through one-way check valves, so that one-way circulation of the damping medium is ensured.

Compared with the prior art, the invention has the following beneficial effects:

the micro-drug delivery device provided by the invention adopts a pure mechanical structure, has a simple structure and is low in manufacturing and using cost; and the micro-drug delivery device with a pure mechanical structure is safe and reliable to use.

Drawings

FIG. 1 is a schematic structural diagram of a first embodiment of the present invention;

FIG. 2 is a schematic representation of the invention in the post-administration state of FIG. 1;

FIG. 3 is a schematic structural diagram of a second embodiment of the present invention;

FIG. 4 is a schematic representation of the invention in the post-administration condition of FIG. 3;

FIG. 5 is a schematic structural diagram of a third embodiment of the present invention;

FIG. 6 is a schematic view of the state of FIG. 5 of the present invention;

fig. 7 is a state diagram of fig. 6 of the present invention.

Detailed Description

The present invention will be further described with reference to the following embodiments.

The clinical diagnosis of diabetes can be divided into type 1 diabetes and type 2 diabetes, also known as non-insulin dependent diabetes, the general population being adults, especially obese, whose condition can lead to wasting, possible causes include insulin resistance, which makes the body unable to use insulin effectively, a reduction in insulin secretion, which is not satisfactory for the body, early stage type 2 diabetes patients can be controlled by improving lifestyle (e.g., healthy diet, exercise in good quantity, safe weight loss, smoking cessation, avoidance of second-hand smoke, etc.), or even cured diabetes, most type 2 diabetes patients can help control body blood glucose levels by oral administration of hypoglycemic agents or by phased injection of insulin, type 1 diabetes, also known as insulin dependent diabetes, the condition of the patient usually occurring in children or adolescents, is a disease inherited from the congenital family, type 1 diabetes is an autoimmune disease, the body's immune system attacks β cells producing insulin in vivo, which ultimately results in the inability to produce insulin in vivo, such patients need to inject insulin to control blood glucose levels in vivo, type 1 diabetes typically requires 24 hours of electronic insulin pumps to treat type 1 diabetes.

The invention discloses a micro-drug delivery device for micro-fluid drug delivery, which comprises a drug storage cavity 2 and a first cavity 3 which are formed by a first piston 1 in a separating way. The drug storage chamber 2 is connected to an infusion device 4. The medicine storage cavity 2 is filled with fluid medicine in advance, and aiming at diabetics, insulin is filled in the medicine storage cavity 2 in advance. The micro drug delivery device further comprises a second chamber 6 which is in one-way communication with the first chamber 3. Damping media are filled in the first cavity 3 and the second cavity 6, a driving damping mechanism 5 is arranged on one side of the second cavity 6, the driving damping mechanism 5 drives the damping media in the second cavity 6 to flow into the first cavity 3, and then the first piston 1 is driven to move towards the medicine storage cavity 2, and micro-dose administration is achieved. The different structural arrangements of the drive damping mechanism 5 can realize slow small-dose administration and also realize quantitative administration of single large dose.

The driving damping mechanisms 5 in the invention all depend on a pure mechanical structure, have simple structure and are safe and reliable to use. Several embodiments of the drive damping mechanism 5 will be described below.

Example one

As shown in fig. 1, the drive damping mechanism 5 in this embodiment comprises, in order, an excitation switch, a pre-compressed elastic material 51 and a second piston 52, the second piston 52 being provided at one end of the second chamber 6. And when the excitation switch is turned on, the precompressed elastic material 51 transmits elastic force to the second piston 52, the second piston 52 drives the damping medium in the second cavity 6 to flow into the first cavity 3, and then the first piston 1 is driven to move towards the medicine storage cavity 2, so that micro-dose administration is realized.

In this embodiment, the trigger switch is a push button switch. The push button switch in this embodiment is of a rotary type. The push button switch comprises a nut 53 and a fixing rod 54, with a pre-compressed resilient material 51 provided between the nut 53 and the second piston 52. The fixing rod 54 has one end passing through the nut 53 and the pre-compressed elastic material 51 and is detachably coupled to the second piston 52. Specifically, the fixing rod 54 is screwed to the second piston 52. In specific operation, only the fixing rod 54 needs to be rotated to separate the end of the fixing rod 54 from the second piston 52, and then the pre-compressed elastic material 51 releases elastic potential energy to push the second piston 52, so that the second piston 52 drives the damping medium in the second chamber 6 to flow into the first chamber 3. The first piston 1 moves towards the medicine storage cavity 2 under the pushing of the damping medium in the first cavity 3, so that the liquid medicine in the medicine storage cavity 2 is delivered to a patient through the infusion device 4; the state after administration is schematically shown in fig. 2. Further, a structure capable of realizing the same or similar functions as the push button switch, or other variations and modifications without departing from the scope of the inventive concept of the present embodiment should also be construed as the scope of protection of the present embodiment.

In this embodiment, the pre-compressed elastic material 51 may be a pre-compressed elastic member, such as a pre-compressed spring; such pre-compressed resilient material 51 is relatively inexpensive to manufacture and use. The second cavity 6 is connected with the first cavity 3 through a one-way check valve 7, and one-way circulation of damping media is guaranteed. The one-way check valve 7 can adopt a valve body which can realize one-way circulation of damping medium and does not flow back, such as a capillary one-way valve, and the like, thereby ensuring that the trace administration device can be used safely and reliably.

With the micro drug delivery device driving the damping mechanism 5 disclosed in this embodiment, a sustained slow infusion of a small dose of the fluid drug, i.e., insulin, can be achieved.

Example two

As shown in fig. 3, the drive damping mechanism 5 in this embodiment includes a pressurizing member 55, an elastic material 56, and a third piston 57 in this order, and the third piston 57 is provided at one end of the second chamber 6. The elastic material 56 is applied with pressure by the pressurizing member 55, the elastic material 56 transmits the pressure to the third piston 57, and the third piston 57 drives the damping medium in the second chamber 6 to flow into the first chamber 3; the state after administration is schematically shown in fig. 4.

In this embodiment, the elastic material 56 may be a spring, which is relatively inexpensive to manufacture and use. The second cavity 6 is connected with the first cavity 3 through a one-way check valve 7, and one-way circulation of damping media is guaranteed. The one-way check valve 7 can adopt a valve body which can realize one-way circulation of damping medium and does not flow back, such as a capillary one-way valve, and the like, thereby ensuring that the trace administration device can be used safely and reliably.

With the micro drug delivery device driving the damping mechanism 5 disclosed in the present embodiment, it is possible to achieve a single injection of a relatively large dose of fluid drug, i.e., insulin.

EXAMPLE III

As shown in fig. 5, in the present embodiment, the second cavity 6 includes a left cavity 61 and a right cavity 62, and the left cavity 61 and the right cavity 62 are respectively communicated to the first cavity 3 in a unidirectional manner. The left cavity 61 and the right cavity 62 are filled with damping media, respectively. The drive damping mechanism 5 includes a first drive damping mechanism and a second drive damping mechanism. The first driving damping mechanism uses the driving damping mechanism of the first embodiment, which sequentially includes the excitation switch, the pre-compressed elastic material 51 and the second piston 52, the second piston 52 is disposed at one end of the left cavity 61, the excitation switch is turned on, the pre-compressed elastic material 51 transmits the elastic force to the second piston 52, and the second piston 52 drives the damping medium in the left cavity 61 to flow into the first cavity 3. The second drive damping mechanism uses the drive damping mechanism of the second embodiment, which includes the pressurizing member 55, the elastic material 56, and the third piston 57 in this order, the third piston 57 is disposed at one end of the right chamber 62, the pressurizing member 55 applies pressure to the elastic material 56, the elastic material 56 transmits the pressure to the third piston 57, and the third piston 57 drives the damping medium in the right chamber 62 to flow into the first chamber 3. A schematic view of a micro-drug delivery device employing a first driving damping mechanism after drug delivery is shown in FIG. 6, and a schematic view of a micro-drug delivery device employing a second driving damping mechanism after drug delivery is shown in FIG. 7.

The pressing member 55 in this embodiment is a pressing bar. The pressure bar abuts one end of the elastomeric material 56 to facilitate the application of pressure to the elastomeric material 56.

In this embodiment, the left cavity 61 and the right cavity 62 are respectively connected to the first cavity 3 through the one-way check valve 7, so as to ensure the one-way circulation of the damping medium. The one-way check valve 7 can adopt a valve body which can realize one-way circulation of damping medium and does not flow back, such as a capillary one-way valve, and the like, thereby ensuring that the trace drug delivery device can be used safely and reliably.

The drive damping mechanism 5 in this embodiment combines the two drive damping mechanisms 5 of the first and second embodiments, so that the entire micro drug delivery device can achieve both a sustained slow infusion of a small dose of insulin and a slow infusion of a disposable large dose of insulin.

In this embodiment, the trigger switch is a push button switch. The push button switch in this embodiment is of a rotary type. The push button switch comprises a nut 53 and a fixing rod 54, with a pre-compressed resilient material 51 provided between the nut 53 and the second piston 52. The fixing rod 54 has one end passing through the nut 53 and the pre-compressed elastic material 51 and is detachably coupled to the second piston 52. Specifically, the fixing rod 54 is screwed to the second piston 52. In specific operation, only the fixing rod 54 needs to be rotated to separate the end of the fixing rod 54 from the second piston 52, and then the pre-compressed elastic material 51 releases elastic potential energy to push the second piston 52, so that the second piston 52 drives the damping medium in the second chamber 6 to flow into the first chamber 3. The first piston 1 moves towards the drug storage chamber 2 under the pushing of the damping medium in the first cavity 3, so that the fluid drug in the drug storage chamber 2 is administered to the patient through the infusion device 4. Further, a structure capable of realizing the same or similar functions as the push button switch, or other variations and modifications without departing from the scope of the inventive concept of the present embodiment should also be construed as the scope of protection of the present embodiment.

The micro-drug delivery device provided by the invention adopts a pure mechanical structure, has a simple integral structure and is low in manufacturing and using cost; and the micro-drug delivery device with a pure mechanical structure is safe and reliable to use.

The foregoing is only a few embodiments of the present invention, and it should be noted that other variations and modifications could be made by those skilled in the art without departing from the inventive concept of the present invention, which falls within the scope of the appended claims.

Claims

1. The micro-administration device is used for administration of micro-fluid medicines and is characterized by comprising a medicine storage cavity and a first cavity which are formed by separating a first piston, wherein the medicine storage cavity is connected with an infusion device; the micro-drug delivery device is characterized by further comprising a second cavity communicated to the first cavity in a one-way mode, damping media are filled in the first cavity and the second cavity, a driving damping mechanism is arranged on one side of the second cavity and drives the damping media in the second cavity to flow into the first cavity, and then the first piston is driven to move towards the drug storage cavity, so that micro-drug delivery is achieved.

2. The device of claim 1, wherein the actuating damping mechanism comprises, in order, an activation switch, a pre-compressed resilient material, and a second piston disposed at an end of the second chamber, wherein opening the activation switch causes the pre-compressed resilient material to transmit a biasing force to the second piston, and wherein the second piston drives the damping medium in the second chamber into the first chamber.

3. The device of claim 1, wherein the actuating damping mechanism comprises a pressure member, an elastic material, and a third piston in sequence, the third piston is disposed at one end of the second chamber, the pressure member applies pressure to the elastic material, the elastic material transmits the pressure to the third piston, and the third piston drives the damping medium in the second chamber to flow into the first chamber.

4. The micro drug delivery device of claim 1, wherein the second chamber comprises a left chamber and a right chamber, the left chamber and the right chamber are respectively communicated with the first chamber in a unidirectional manner, and the left chamber and the right chamber are respectively filled with damping media; the driving damping mechanism comprises a first driving damping mechanism and a second driving damping mechanism, the first driving damping mechanism sequentially comprises an excitation switch, a pre-compressed elastic material and a second piston, the second piston is arranged at one end of the left cavity, the excitation switch is opened, the pre-compressed elastic material transmits elastic pressure to the second piston, and the second piston drives the damping medium in the left cavity to flow into the first cavity; the second driving damping mechanism comprises a pressurizing piece, an elastic material and a third piston in sequence, the third piston is arranged at one end of the right cavity, the pressurizing piece applies pressure to the elastic material, the elastic material transmits the pressure to the third piston, and the damping medium in the right cavity of the third piston is driven to flow into the first cavity.

5. The micro drug delivery device of claim 2 or 4, wherein the pre-compressed resilient material is a pre-compressed spring.

6. The micro drug delivery device of claim 3 or 4, wherein the resilient material is a spring.

7. The micro drug delivery device of claim 2 or 4, wherein the activation switch is a push button switch.

8. The micro drug delivery device of claim 6, wherein the pressure member is a pressure bar that abuts an end of the resilient material.

9. The micro drug delivery device of claim 1, wherein the second chamber is connected to the first chamber by a one-way check valve.

10. The micro drug delivery device of claim 4, wherein the left and right chambers are each connected to the first chamber by a one-way check valve.