CN110859596A - Miniature gas-sensitive electronic capsule for detecting gas in human gastrointestinal tract - Google Patents

Miniature gas-sensitive electronic capsule for detecting gas in human gastrointestinal tract Download PDF

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CN110859596A
CN110859596A CN201911112567.7A CN201911112567A CN110859596A CN 110859596 A CN110859596 A CN 110859596A CN 201911112567 A CN201911112567 A CN 201911112567A CN 110859596 A CN110859596 A CN 110859596A
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gas
gastrointestinal tract
pull
module
capsule
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CN201911112567.7A
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Chinese (zh)
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余隽
朱思鹏
黄正兴
唐祯安
李晓干
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Dalian University of Technology
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Dalian University of Technology
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    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/0004Gaseous mixtures, e.g. polluted air
    • G01N33/0009General constructional details of gas analysers, e.g. portable test equipment
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00Measuring for diagnostic purposes; Identification of persons
    • A61B5/0002Remote monitoring of patients using telemetry, e.g. transmission of vital signals via a communication network
    • A61B5/0004Remote monitoring of patients using telemetry, e.g. transmission of vital signals via a communication network characterised by the type of physiological signal transmitted
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00Measuring for diagnostic purposes; Identification of persons
    • A61B5/42Detecting, measuring or recording for evaluating the gastrointestinal, the endocrine or the exocrine systems
    • A61B5/4222Evaluating particular parts, e.g. particular organs
    • A61B5/4238Evaluating particular parts, e.g. particular organs stomach
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00Measuring for diagnostic purposes; Identification of persons
    • A61B5/42Detecting, measuring or recording for evaluating the gastrointestinal, the endocrine or the exocrine systems
    • A61B5/4222Evaluating particular parts, e.g. particular organs
    • A61B5/4255Intestines, colon or appendix
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00Measuring for diagnostic purposes; Identification of persons
    • A61B5/68Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient
    • A61B5/6846Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient specially adapted to be brought in contact with an internal body part, i.e. invasive
    • A61B5/6847Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient specially adapted to be brought in contact with an internal body part, i.e. invasive mounted on an invasive device
    • A61B5/6861Capsules, e.g. for swallowing or implanting
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00Measuring for diagnostic purposes; Identification of persons
    • A61B5/68Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient
    • A61B5/6846Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient specially adapted to be brought in contact with an internal body part, i.e. invasive
    • A61B5/6867Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient specially adapted to be brought in contact with an internal body part, i.e. invasive specially adapted to be attached or implanted in a specific body part
    • A61B5/6871Stomach
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00Measuring for diagnostic purposes; Identification of persons
    • A61B5/68Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient
    • A61B5/6846Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient specially adapted to be brought in contact with an internal body part, i.e. invasive
    • A61B5/6867Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient specially adapted to be brought in contact with an internal body part, i.e. invasive specially adapted to be attached or implanted in a specific body part
    • A61B5/6873Intestine

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Veterinary Medicine (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Medical Informatics (AREA)
  • Molecular Biology (AREA)
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  • Animal Behavior & Ethology (AREA)
  • Biomedical Technology (AREA)
  • Public Health (AREA)
  • Biophysics (AREA)
  • Physiology (AREA)
  • Chemical & Material Sciences (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Endocrinology (AREA)
  • Computer Networks & Wireless Communication (AREA)
  • Combustion & Propulsion (AREA)
  • Food Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Immunology (AREA)
  • Investigating Or Analyzing Materials By The Use Of Electric Means (AREA)

Abstract

The invention relates to the field of biomedical signal detection, and particularly discloses a miniature gas-sensitive electronic capsule for detecting gas in human gastrointestinal tract, wherein the sensor is designed in a chip-level array manner, four micro-hotplate type gas sensors are integrated on a single chip, and the four sensors are coated with different gas-sensitive materials, so that the selectivity and the sensitivity of the capsule to different gases in the human gastrointestinal tract can be improved; the inside wireless transceiver module that contains of capsule, this module adopt bluetooth communication technology, and the patient's cell-phone can be connected with gas-sensitive capsule through installing special APP, accepts the interior gaseous information of gastrointestinal tract that the capsule sent, can save external special receiver, and reduce cost alleviates the patient and wears the burden. The invention has the advantages of high accuracy, low cost and convenient use, and can accurately reflect the gas information in the gastrointestinal tract of the human body in real time.

Description

Miniature gas-sensitive electronic capsule for detecting gas in human gastrointestinal tract
Technical Field
The invention belongs to the technical field of biomedical signal detection, and particularly relates to a miniature gas-sensitive electronic capsule for detecting gas in human gastrointestinal tract.
Background
Ingestible sensors are powerful tools for monitoring human health, which can be directly immersed in the intestinal tract to obtain information from the human gastrointestinal tract. However, the area of ingestible sensors remains a relatively underdeveloped technology area. An ingestible gas-sensitive capsule currently used for gas detection in the human gastrointestinal tract is from the 2018 article "Ahumpilot ternary of ingestilbe electronic capsules capable of sensing differential gases in the gut". However, the micro gas-sensitive capsule involved in the method adopts a single sensor, and the selectivity and the sensitivity of the micro gas-sensitive capsule to different gases are controlled only by adjusting the working temperature of the sensor, so that the method faces to the complicated gas environment of the gastrointestinal tract, and the amount of detectable gas information is small; meanwhile, the device for receiving the gastrointestinal tract gas information is a special receiver, which needs to be worn by the patient all the time during the detection, thus increasing the wearing burden of the patient and increasing the cost.
Disclosure of Invention
To the above-mentioned problem that prior art exists, the application provides a miniature gas sensitive electronic capsule for human gastrointestinal tract gas detection, and it has the accuracy height, low cost, uses convenient advantage, can accurately react human gastrointestinal tract interior gas information in real time.
In order to achieve the purpose, the technical scheme of the application is as follows: a micro gas-sensitive electronic capsule for detecting gas in human gastrointestinal tract comprises a shell, wherein a gas exchange hole is arranged in the middle of one end of the shell, and is covered by a water-proof breathable film, so that dissolved gas can be rapidly diffused, liquid can be effectively blocked, and the micro gas-sensitive electronic capsule is used for exchanging gas between the inside of the shell and the outside; a sensor module and a data processing module are arranged in the shell;
the sensor module comprises a micro-hotplate array type gas sensing structure U1, a voltage stabilizing module U2, a pull-up resistor R1, a pull-up resistor R2, a bypass capacitor C1, a filter capacitor C2 and a filter capacitor C3; the micro-hotplate array type gas sensing structure U1 comprises four micro-hotplate type gas sensors integrated on a single chip and used for collecting gas information and outputting signals; a power end pin VDD of the micro-hotplate array type gas sensing structure U1 is connected with a bypass capacitor C1 and used for eliminating high-frequency noise in a circuit, a communication end SCL and an SDA are respectively connected with a pull-up resistor R1 and a pull-up resistor R2, and the communication end SCL and the SDA are in data transmission with a data processing module; an input power supply end pin VIN of the voltage stabilizing module U2 is connected with a filter capacitor C2, so that input ripples are suppressed; output power supply end pin VOUT of voltage stabilizing module U2 is connected with filter capacitor C3, and the ripple that produces after the suppression stabiliser carries out voltage conversion guarantees that the voltage curve of output is smooth, and voltage stabilizing module U2 is used for providing stable 1.8V voltage.
The data processing module comprises a processor U3, a Bluetooth module U4, a voltage stabilizing module U5, a passive crystal oscillator YC1, a filter capacitor C4, a filter capacitor C5, a capacitor C6, a capacitor C7, a pull-up resistor R5, a pull-down resistor R4 and a pull-down resistor R3, wherein the processor U3 is connected with the passive crystal oscillator YC1, and the passive crystal oscillator YC1 is also respectively connected with the capacitor C6 and the capacitor C7 to provide a clock signal for the STM32 processor U3; the pull-down resistor R4 and the pull-down resistor R3 are respectively connected with the PB2 end and the BOOT0 end of the processor U3, so that the protection effect is achieved, and the current is prevented from being overlarge; the pull-up resistor R5 and the filter capacitor C4 are connected in parallel and then connected with an RSET end of the processor U3, an input power supply terminal pin VIN of the voltage stabilizing module U5 is connected with the filter capacitor C5, and an output power supply terminal pin VOUT is connected with the filter capacitor C3;
the sensor module is connected with the data processing module through four leads, and sends data acquired by each sensor to the processor U3 for processing; the RX end and the TX end of the Bluetooth module U4 are connected with the PA10 end and the PA9 end of the processor U3, and data received by the processor U3 are sent to an external mobile phone end.
Furthermore, the four micro-hotplate type gas sensors are respectively coated with different gas-sensitive materials, so that the selectivity and the sensitivity of the capsule to different gases in the gastrointestinal tract of a human body can be improved.
Furthermore, the shell is cylindrical, is made of medical high polymer material polyethylene, is acid-resistant and corrosion-resistant, and is safe to a human body.
Further, the sensor module is arranged on a circular circuit board inside the shell.
Further, the diameter of the sensor module is 9mm, and the thickness of the sensor module is 2 mm; the size of the data processing module is 14mm multiplied by 9mm multiplied by 2 mm; the diameter of the shell is 9.8mm, the length is 26mm, and the thickness is 0.4 mm.
Further, the gas exchange holes are circular holes with a diameter of 2 mm.
Due to the adoption of the technical scheme, the invention can obtain the following technical effects:
(1) because the micro-hotplate gas sensor adopts a chip-level array design, four gas sensors are integrated on a single chip, and the selectivity and the sensitivity of the design to different gases are far higher than those of the existing design adopting a single sensor, the gas-sensitive capsule has high accuracy in acquiring the gas information of the gastrointestinal tract.
(2) The gas-sensitive capsule is directly connected with the mobile phone by using the Bluetooth communication technology, so that an external special receiver can be omitted, the production cost is reduced, and the wearing burden of a patient is lightened.
(3) The microcapsule has low cost and is suitable for wide clinical application.
Drawings
FIG. 1 is a side view of a miniature gas-sensitive electronic capsule of the present application;
FIG. 2 is a top view of a miniature gas-sensitive electronic capsule of the present application;
FIG. 3 is a front view of a miniature gas-sensitive electronic capsule of the present application;
FIG. 4 is a schematic diagram of a micro-hotplate array gas sensor configuration;
FIG. 5 is a schematic diagram of a front side structure of a sensor module circuit board;
FIG. 6 is a schematic diagram of a reverse structure of a sensor module circuit board;
FIG. 7 is a schematic diagram of a front side structure of a circuit board of the data processing module;
FIG. 8 is a schematic diagram of a reverse side of a circuit board of the data processing module;
the sequence numbers in the figures illustrate: 1, a shell; 2, a bonding pad; 3, a water-proof and air-permeable film; 4 gas exchange holes; 5, a circular circuit board; 6 data processing module circuit board; 7, a button cell; 8 gas sensor a; 9 gas sensor b; 10 gas sensor c; 11 gas sensor d.
Detailed Description
The embodiments of the present invention are implemented on the premise of the technical solution of the present invention, and detailed embodiments and specific operation procedures are given, but the scope of the present invention is not limited to the following embodiments.
Example 1
As shown in fig. 1, 2 and 3, the micro gas-sensitive capsule for gastrointestinal gas detection comprises a shell, wherein the shell is made of medical high polymer material polyethylene, is acid-resistant, corrosion-resistant and safe to human body, and has a diameter of 9.8mm and a height of 26 mm; the top of the shell is provided with an opening with the diameter of 2mm, and the opening is covered by a water-proof and breathable film, so that dissolved gas can be rapidly diffused, liquid can be effectively blocked, and the gas exchange between the interior of the capsule and the outside can be realized; a sensor module, a data processing module and a button battery are arranged in the shell;
the sensor module comprises a micro-hotplate array type gas sensing structure U1, a peripheral circuit and a circular circuit board, wherein the diameter of the circular circuit board is 9mm, and the thickness of the circular circuit board is 2 mm; the data processing module comprises an STM32 processor U3, a Bluetooth module U4, a peripheral circuit and a data processing module circuit board, wherein the circuit board is rectangular and has the size of 14mm multiplied by 9mm multiplied by 2 mm; the battery adopts a silver oxide button battery, has small volume and high safety, has a diameter of 7.9mm and a thickness of 2.6mm, and needs 3 sections.
As shown in fig. 4, the micro-hotplate array gas sensing structure U1 adopts an array design, and a single chip includes four sensors, namely a gas sensor a, a gas sensor b, a gas sensor c, and a gas sensor d, which are coated with different gas-sensitive materials, and have different selectivity and sensitivity to different gases, so that gas-sensitive signals of a plurality of gases can be simultaneously collected. The chip is square in shape and has a size of 2mm × 2 mm.
As shown in fig. 5 and 6, the gas sensor and the peripheral circuit are disposed on both sides of a circular circuit board. The sensor module comprises a gas information acquisition module and a power supply module, and four bonding pads on the back of the circuit board are respectively a power supply, a ground and a signal transmission end and are connected with the corresponding bonding pads of the data processing module through four wires. The power supply adopts a 3.3v direct current power supply for power supply. The core of the gas information acquisition module is a micro-hotplate array type gas sensor U1, the device adopts a chip-level array design, four sensors are integrated on a single chip, the sensors can acquire gas-sensitive information with ppb level of concentration, the sampling frequency can reach 40Hz at most, and the gas information in the gastrointestinal tract can be accurately acquired. The micro-hotplate array type gas sensing structure U1 is connected with a bypass capacitor C1 at a power supply end and used for eliminating high-frequency noise in a circuit; the power module core is voltage stabilizing chip U2, and input voltage is 3.3V, and output voltage is 1.8V, and voltage stabilizing module U2's input power end pin VIN is connected with filter capacitor C2, suppresses the input ripple, and output power end pin VOUT is connected with filter capacitor C3, suppresses the ripple that the stabiliser produced after carrying out the voltage conversion, guarantees that the voltage curve of output is smooth, and voltage stabilizing module U2 is used for providing stable 1.8V voltage.
As shown in fig. 7 and 8, the circuits of the signal processing module are arranged on both sides of the circuit board, and the power supply is supplied by three silver oxide button batteries in series, and the voltage is 4.5V. The signal processing module comprises a processor, a Bluetooth communication module and a power module. The processor is an STM32 processor U3, the processor adopts a Cortex-M3 kernel of ARM company, supports UART, I2C and other communication protocols, meets the communication requirements of the capsule, adopts VFQFPN packaging, is small in size and is suitable for miniaturization design. The passive crystal oscillator YC1 is connected with a capacitor C6 and a capacitor C7 and provides a clock signal for an STM32 processor U3; the pull-down resistor R4 and the pull-down resistor R3 are respectively connected with the PB2 end and the BOOT0\ end of the STM32 processor U3 to play a role in limiting current; the pull-up resistor R5 is connected in parallel with the capacitor C4 and then connected to the RSET terminal of the processor U3, thereby preventing the processor U3 from resetting due to voltage fluctuations. The size of the Bluetooth module U4 structure is 9.7mm multiplied by 6.5mm, an onboard antenna is adopted, the data transmission distance is about 15m, and the special APP for the mobile phone installation of the patient can be linked with the capsule to transmit data; the RX end and the TX end of the Bluetooth module U4 are connected with the PA10 end and the PA9 end of the STM32 processor U3, a UART serial port communication protocol is adopted, and data received by the STM32 processor U3 are sent to the mobile phone APP to be received. The power module core is voltage stabilizing chip U5, and input voltage is 4.5V, and output voltage is 3.3V, and voltage stabilizing module U5's input power end pin VIN is connected with filter capacitor C5, restraines the input ripple, and output power end pin VOUT is connected with filter capacitor C3, guarantees that the voltage curve of output is smooth, and voltage stabilizing module U5 is used for providing stable 3.3V voltage.
The invention is based on the micro-hotplate array gas sensor technology, the gas sensor adopts an array design, four micro-hotplate gas sensors are integrated on a single chip, the four sensors are coated with different gas-sensitive materials, and the selectivity and the sensitivity of the design on different gases are far higher than those of the existing design; the patient's cell-phone can be connected with the quick capsule of gas through the special APP of installation, accepts the interior gas information of intestines and stomach that the capsule sent, and this kind of design does not need dedicated receiver, can alleviate the patient and wear burden, reduce cost.
The above description is only a preferred embodiment of the present invention and is not intended to limit the present invention, it should be noted that, for those skilled in the art, many modifications and variations can be made without departing from the technical principle of the present invention, and these modifications and variations should also be regarded as the protection scope of the present invention.

Claims (6)

1. A micro gas-sensitive electronic capsule for detecting gas in human gastrointestinal tract is characterized by comprising a shell, wherein the middle part of one end of the shell is provided with a gas exchange hole which is covered by a water-proof and breathable film; a sensor module and a data processing module are arranged in the shell;
the sensor module comprises a micro-hotplate array type gas sensing structure U1, a voltage stabilizing module U2, a pull-up resistor R1, a pull-up resistor R2, a bypass capacitor C1, a filter capacitor C2 and a filter capacitor C3; the micro-hotplate array type gas sensing structure U1 comprises four micro-hotplate type gas sensors integrated on a single chip and used for collecting gas information and outputting signals; a power end pin VDD of the micro-hotplate array type gas sensing structure U1 is connected with a bypass capacitor C1, communication ends SCL and SDA are respectively connected with a pull-up resistor R1 and a pull-up resistor R2, and the communication ends SCL and SDA and a data processing module perform data transmission; an input power supply terminal pin VIN of the voltage stabilizing module U2 is connected with the filter capacitor C2, and an output power supply terminal pin VOUT of the voltage stabilizing module U2 is connected with the filter capacitor C3;
the data processing module comprises a processor U3, a Bluetooth module U4, a voltage stabilizing module U5, a passive crystal oscillator YC1, a filter capacitor C4, a filter capacitor C5, a capacitor C6, a capacitor C7, a pull-up resistor R5, a pull-down resistor R4 and a pull-down resistor R3, wherein the processor U3 is connected with the passive crystal oscillator YC1, the passive crystal oscillator YC1 is also connected with the capacitor C6 and the capacitor C7 respectively, the pull-down resistor R4 and the pull-down resistor R3 are connected with a PB2 end and a BOOT0 end of the processor U3 respectively, the pull-up resistor R5 and the filter capacitor C4 are connected in parallel and then connected with an RSET end of the processor U3, an input power supply terminal pin of the voltage stabilizing module U5 is connected with the filter capacitor C VIN 5, and an output power supply terminal is connected with a filter capacitor C3 VOUT;
the sensor module is connected with the data processing module through four leads, and sends data acquired by each sensor to the processor U3 for processing; the RX end and the TX end of the Bluetooth module U4 are connected with the PA10 end and the PA9 end of the processor U3, and data received by the processor U3 are sent to an external mobile phone end.
2. The miniature gas-sensitive electronic capsule for gas detection in the gastrointestinal tract of a human body according to claim 1, wherein four micro hot plate gas sensors are coated with different gas-sensitive materials respectively.
3. The miniature gas-sensitive electronic capsule for gas detection in the gastrointestinal tract of a human body according to claim 1, wherein the shell is cylindrical and made of medical high polymer material polyethylene.
4. The miniature gas-sensitive electronic capsule for gas detection in the gastrointestinal tract of a human body according to claim 1, wherein the sensor module is disposed on a circular circuit board inside the housing.
5. The miniature gas-sensitive electronic capsule for gas detection in the gastrointestinal tract of a human body according to claim 1, wherein the sensor module has a diameter of 9mm and a thickness of 2 mm; the size of the data processing module is 14mm multiplied by 9mm multiplied by 2 mm; the diameter of the shell is 9.8mm, the length is 26mm, and the thickness is 0.4 mm.
6. The miniature gas-sensitive electronic capsule for gas detection in the gastrointestinal tract of a human body according to claim 1, wherein the gas exchange hole is a circular hole with a diameter of 2 mm.
CN201911112567.7A 2019-11-14 2019-11-14 Miniature gas-sensitive electronic capsule for detecting gas in human gastrointestinal tract Pending CN110859596A (en)

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Publication number Priority date Publication date Assignee Title
CN113063901A (en) * 2021-04-06 2021-07-02 哈尔滨理工大学 Device for monitoring hydrogen concentration inside oil-immersed bushing on line

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Application publication date: 20200306