CN1108535A - 心脏基础液及其制备工艺 - Google Patents

心脏基础液及其制备工艺 Download PDF

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CN1108535A
CN1108535A CN 94116227 CN94116227A CN1108535A CN 1108535 A CN1108535 A CN 1108535A CN 94116227 CN94116227 CN 94116227 CN 94116227 A CN94116227 A CN 94116227A CN 1108535 A CN1108535 A CN 1108535A
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potassium
injection
acid
basal liquid
dihydrogen phosphate
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CN 94116227
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郑企琨
谭光强
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GUANGZHOU CITY RED CROSS HOSPITAL
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GUANGZHOU CITY RED CROSS HOSPITAL
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Priority to CN 94116227 priority Critical patent/CN1108535A/zh
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Abstract

本发明涉及一种用于人体电解质的补充，并参与 心肌细胞能量代谢的注射液及制备工艺。其成分含 有醋酸钾、磷酸二氢钾、氢氧化钾、氧化镁、L-门冬氨 酸、L-苹果酸、山梨醇，以注射用水溶解。该产品能 有效地提高细胞内的钾镁离子量，对心肌有正性肌力 的作用，改善休克后的内环境，稳定血压，有利尿作 用，且有稳定细胞膜的作用，加强重碳酸盐的重吸收， 调节pH。

Description

本发明涉及一种用于人体电解质的补充，并参与心肌细胞能量代谢的注射液及其制备工艺。
目前临床所使用的基础液有GIK（含10%葡萄糖500ml，10%KCL22.5ml，普通胰岛素12IU）和1，6-二磷酸果糖（FDP）。GIK液是通过加强糖原合成的作用，使细胞外钾进入细胞内，糖原分解成丙酮酸，进入三梭酸循环，产生能量。组织缺氧时会对这一机制产生影响。内源性的FDP的葡萄糖氧化的中间产物，外源性的FDP不能进入细胞膜，而主要通过激活磷酸果糖激酶（PFK）的活性，抑制葡萄糖的无氧酵解，加快三梭酸循环的反应速度。PFK的活性与pH，和细胞外的钙离子水平有关，是一种条件型的酶。因此，在缺氧和酸中毒的情况下，这一机制也会受到抑制。
本发明的目的在于提供一种可有效提高细胞内的钾镁离子含量，对心肌有正性肌力作用的心脏基础液及其制备工艺。
本发明的组成及各成分的含量为：醋酸钾1.472g、磷酸二氢钾1.361g、氢氧化钾1.964g、氧化镁0.705g、L-门冬氨酸4.991g、L-苹果酸2.700g、山梨醇50.00g、注射用水900ml，共制成1000ml。其制备工艺为：称取上述含量之醋酸钾、磷酸二氢钾、氧化镁、L-门冬氨酸、L-萍果酸，依顺序溶于900ml注射用水，加热至70℃，搅拌，使完全溶解;再加入山梨醇、氢氧化钾，继续搅拌至溶解，按配制量加0.03%活性碳，搅匀，过滤，滤液添加注射用水使成全量1000ml，趁热滤过至澄明，灌封，以115℃热压灭菌30分钟即得。
下面结合实施例对本发明作详细描述。
称取醋酸钾1.427g、磷酸二氢钾1.361g、氧化镁0.705g、L-门冬氨酸4.991g、L-苹果酸2.700g，依顺序溶于900ml注射用水，加热至70℃，搅拌，使完全溶解。再加入山梨醇50.00g，氢氧化钾1.964g，继续搅拌至溶解。按配制量加0.03%活性碳，搅匀，过滤。滤液添加注射用水使成全量1000ml，趁热滤过至澄明，灌封，以115℃热压灭菌30分钟，制得规格250ml/瓶或500ml/瓶之产品。
基础液对提高细胞内的钾镁水平的作用机制是多方面的。苹果酸有稳定细胞膜的作用。门冬氨酸可作为载体，将细胞外的钾镁转移到细胞内，或腺粒体内。在缺氧不严重的情况下，这一机制不受影响。门冬氨酸参与苹果酸-门冬酸酸穿梭反应，加快处理还原型辅酶（NADH）转化为还原型辅助酶的过程，使丙酸酸还原成乳酸的过程受到抑制，有利于三梭酸循环的进行。在缺氧时，萍果酸是腺粒体内ATP的重要来源之一。苹果酸还可以使肾小球对重碳酸盐的重吸收增加，促进肝脏对血氨的代谢反应速度，使pH升高，处理酸中毒的能力加强。
本发明的优点：
（一）使用有机钾盐和体内镁的正常结合形式补充钾镁，含有门冬氨酸，可以作为钾镁离子的载体，将钾镁向细胞内转移，有效提高细胞内的钾镁离子含量，对心肌有正性肌力的作用，改善休克后的内环境，稳定血压，有利尿作用。
（二）有稳定细胞膜的作用，加强重碳酸盐的重吸收，调节pH。
（三）在补充细胞内电解质的同时，参与细胞内能量代谢。

Claims (2)

1、一种心脏基础液，其特征在于它的组成及各成分的含量为：醋酸钾1.472g、磷酸二氢钾1.361g、氢氧化钾1.964g、氧化镁0.705g、L-门冬氨酸4.991g、L-苹果酸2.700g、山梨醇50.00g、注射用水900ml，共制成1000ml。
2、一种心脏基础液的制备工艺，其特征在于：称取上述含量之醋酸钾、磷酸二氢钾、氧化镁、L-门冬氨酸、L-萍果酸，依顺序溶于900ml注射用水，加热至70℃，搅拌，使完全溶解;再加入山梨醇、氢氧化钾，继续搅拌至溶解，按配制量加0.03%活性碳，搅匀，过滤，滤液添加注射用水使成全量1000ml，趁热滤过至澄明，灌封，以115℃热压灭菌30分钟即得。
CN 94116227 1994-09-20 1994-09-20 心脏基础液及其制备工艺 Pending CN1108535A (zh)

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CN 94116227 CN1108535A (zh) 1994-09-20 1994-09-20 心脏基础液及其制备工艺

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Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1090483C (zh) * 1997-07-31 2002-09-11 谢理峰 钾镁缓释片及生产方法
CN107468705A (zh) * 2017-09-01 2017-12-15 济南康和医药科技有限公司 一种复方电解质葡萄糖注射液及其制备方法

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1090483C (zh) * 1997-07-31 2002-09-11 谢理峰 钾镁缓释片及生产方法
CN107468705A (zh) * 2017-09-01 2017-12-15 济南康和医药科技有限公司 一种复方电解质葡萄糖注射液及其制备方法

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