CN110845127A - Ampoule wire drawing packaging system and fusion sealing method - Google Patents
Ampoule wire drawing packaging system and fusion sealing method Download PDFInfo
- Publication number
- CN110845127A CN110845127A CN201911255553.0A CN201911255553A CN110845127A CN 110845127 A CN110845127 A CN 110845127A CN 201911255553 A CN201911255553 A CN 201911255553A CN 110845127 A CN110845127 A CN 110845127A
- Authority
- CN
- China
- Prior art keywords
- ampoule
- vacuum
- bottle
- packaging machine
- wire drawing
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 239000003708 ampul Substances 0.000 title claims abstract description 73
- 238000004806 packaging method and process Methods 0.000 title claims abstract description 37
- 238000005491 wire drawing Methods 0.000 title claims abstract description 31
- 238000007789 sealing Methods 0.000 title claims abstract description 29
- 238000000034 method Methods 0.000 title claims abstract description 13
- 230000004927 fusion Effects 0.000 title abstract description 9
- 239000011521 glass Substances 0.000 claims abstract description 14
- 239000011261 inert gas Substances 0.000 claims abstract description 11
- 238000002844 melting Methods 0.000 claims abstract description 6
- 230000008018 melting Effects 0.000 claims abstract description 6
- 239000012472 biological sample Substances 0.000 claims abstract description 4
- 238000005086 pumping Methods 0.000 claims description 6
- 238000010438 heat treatment Methods 0.000 claims description 5
- 230000007547 defect Effects 0.000 abstract description 3
- 230000009286 beneficial effect Effects 0.000 abstract description 2
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 description 16
- 229910052757 nitrogen Inorganic materials 0.000 description 8
- 239000000523 sample Substances 0.000 description 5
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 description 4
- 239000001301 oxygen Substances 0.000 description 4
- 229910052760 oxygen Inorganic materials 0.000 description 4
- 239000003814 drug Substances 0.000 description 3
- 239000007789 gas Substances 0.000 description 3
- 239000001307 helium Substances 0.000 description 3
- 229910052734 helium Inorganic materials 0.000 description 3
- SWQJXJOGLNCZEY-UHFFFAOYSA-N helium atom Chemical compound [He] SWQJXJOGLNCZEY-UHFFFAOYSA-N 0.000 description 3
- 238000004321 preservation Methods 0.000 description 3
- 239000000126 substance Substances 0.000 description 3
- 238000003860 storage Methods 0.000 description 2
- 206010021143 Hypoxia Diseases 0.000 description 1
- 230000015556 catabolic process Effects 0.000 description 1
- 238000006731 degradation reaction Methods 0.000 description 1
- 238000010586 diagram Methods 0.000 description 1
- 229940079593 drug Drugs 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 230000001146 hypoxic effect Effects 0.000 description 1
- 238000009776 industrial production Methods 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 230000003647 oxidation Effects 0.000 description 1
- 238000007254 oxidation reaction Methods 0.000 description 1
- 102000004169 proteins and genes Human genes 0.000 description 1
- 108090000623 proteins and genes Proteins 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C03—GLASS; MINERAL OR SLAG WOOL
- C03B—MANUFACTURE, SHAPING, OR SUPPLEMENTARY PROCESSES
- C03B23/00—Re-forming shaped glass
- C03B23/18—Re-forming and sealing ampoules
Abstract
The invention discloses an ampoule wire drawing packaging system which comprises a vacuum inflation box and an ampoule wire drawing packaging machine, wherein an ampoule bottle is placed in the vacuum inflation box, an opening is formed in the top end of a bottle body of the ampoule bottle, and a glass plug is arranged in the opening. The wire drawing and melt sealing method specifically comprises the following steps: placing the ampoule bottle body filled with the biological sample in a vacuum inflation box; repeatedly and circularly vacuumizing and filling inert gas until the inert gas pressure is balanced with the outside of the box body, and placing the glass plug into the opening of the ampoule bottle; the ampoule bottle is placed in an ampoule wire-drawing packaging machine, flame heats the lower edge of the bottle plug until the ampoule bottle neck is melted, and the wire-drawing packaging machine draws and seals the bottle neck at the upper end of a melting point together with the glass plug. The invention has the beneficial effects that: the method overcomes the technical defect that the common wire drawing packaging machine can not achieve anaerobic packaging, and has the characteristics of large operation batch, high efficiency, simple and convenient operation and good fusion sealing quality.
Description
Technical Field
The invention relates to an ampoule wire drawing packaging system and a fusion sealing method.
Background
Many biochemicals, pharmaceuticals and biological and chemical samples are unstable due to their susceptibility to oxidation and need to be stored in anaerobic or hypoxic environments, such as human genomic DNA storage samples, active proteins, pharmaceuticals, etc., which are typically stored in oxygen-tight seals. The nitrogen-filled wire drawing filling and sealing machine commonly used in the current industrial production can reduce the oxygen content in the ampoule bottle to 12-15 percent and can not meet the requirement of no oxygen. Although the chinese patent 200910073695.5 discloses that the designed vacuum ampoule sealing machine can reach a vacuum state, it is only suitable for small-scale application in laboratories and is not suitable for industrial mass production.
Disclosure of Invention
The invention aims to overcome the technical defects and provides an ampoule wire drawing packaging system and a fusion sealing method.
In order to achieve the purpose of the invention, the invention adopts the technical scheme that: the utility model provides an ampoule wire drawing packaging system, includes vacuum inflation case, ampoule wire drawing packaging machine, place the ampoule in the vacuum inflation case, the bottle top of ampoule is equipped with the opening, is equipped with the glass stopper in the opening, be equipped with vacuum valve and admission valve on the vacuum inflation case, the vacuum valve is used for connecting the aspiration pump, and the admission valve is used for connecting the inert gas holding vessel, vacuum inflation incasement fixed be equipped with be used for to the stopper controller that falls who places the glass stopper in the ampoule top opening, the ampoule after the stoppering is in melt-seal in the ampoule wire drawing packaging machine.
The wire drawing and sealing method of the ampoule wire drawing and sealing system specifically comprises the following steps:
a. placing the ampoule bottle body filled with the biological sample in a vacuum inflation box;
b. sealing the door of the vacuum inflation box, pumping air to vacuum, closing the vacuum valve, then filling inert gas to 0-2% vacuum degree, repeatedly pumping vacuum and filling inert gas, circulating for several times, filling inert gas to balance with the outside of the box body, and closing the air pumping and inlet valves;
c. operating a plug falling controller to place the glass plug into the opening of the ampoule bottle;
d. taking out the ampoule bottle from the vacuum inflation box, placing the ampoule bottle in a common ampoule bottle drawing and packaging machine, heating the lower edge of the bottle plug by flame until the ampoule bottle neck is melted, drawing and sealing the bottle neck at the upper end of a melting point together with the glass plug by the drawing and packaging machine to finish sealing.
The invention has the beneficial effects that: the ampoule drawing packaging system and the ampoule fusing packaging method can be used for biological samples, easily-oxidized chemicals, biochemical products, medicines and various oxygen-sensitive biological and chemical substances which are required to be isolated from air and stored in an oxygen-free state; the invention overcomes the technical defect that the common wire drawing packaging machine can not achieve anaerobic packaging, and has the characteristics of large operation batch, high efficiency, simple and convenient operation and good fusion sealing quality.
Drawings
Fig. 1 is a schematic structural diagram of an ampoule drawing packaging system according to the present invention.
As shown in the figure: 1. the device comprises a vacuum inflation box, 2, an ampoule bottle, 3, a glass plug, 4, a vacuum valve, 5, an air inlet valve, 6 and a plug falling controller.
Detailed Description
The technical solutions of the present invention will be described clearly and completely with reference to the following embodiments of the present invention, and it should be understood that the described embodiments are only a part of the embodiments of the present invention, and not all of the embodiments. All other embodiments, which can be derived by a person skilled in the art from the embodiments given herein without making any creative effort, shall fall within the protection scope of the present invention.
The utility model provides an ampoule wire drawing packaging system, includes vacuum inflation case 1, ampoule wire drawing packaging machine, place ampoule 2 in the vacuum inflation case 1, ampoule 2's bottle top is equipped with the opening, is equipped with glass stopper 3 in the opening, be equipped with vacuum valve 4 and admission valve 5 on the vacuum inflation case 1, vacuum valve 4 is used for connecting the vacuum aspiration pump, and admission valve 5 is used for connecting the inert gas holding vessel, 1 internal fixation of vacuum inflation case is equipped with and is used for to 2 top openings of ampoule place glass stopper 3 fall and fill in controller 6, fill in ampoule 2 after filling in melt-seal in the ampoule wire drawing packaging machine.
Example 1:
the fusion sealing method of the ampoule drawing packaging system specifically comprises the following steps:
a. placing the ampoule bottle body filled with the dried human genome DNA preservation sample in a vacuum inflation box;
b. closing the box door, vacuumizing to 90-95% vacuum degree, closing the vacuum valve, then filling nitrogen to 0-2% vacuum degree, repeatedly vacuumizing and filling nitrogen for 5 times, after 5 times of circulation, filling nitrogen to balance the pressure outside the box body, and closing the air suction and inlet valve;
c. operating the dropping plug controller to put the ampoule bottle plug;
d. taking out the ampoule bottle from the vacuum inflation box, placing a common ampoule wire-drawing packaging machine, heating the lower edge position of the bottle plug by flame until the ampoule bottle neck is melted, and drawing and sealing the bottle neck at the upper end of a melting point together with the bottle plug by the wire-drawing packaging machine to finish sealing.
Example 2:
the fusion sealing method of the ampoule drawing packaging system specifically comprises the following steps:
a. placing the ampoule bottle body filled with the dried human genome DNA preservation sample in a vacuum inflation box;
b. sealing the box door, vacuumizing to 90-95% vacuum degree, closing the vacuum valve, then filling helium gas to 0-2% vacuum degree, repeatedly vacuumizing and filling helium gas for 5 times, after 5 times of circulation, filling helium gas to balance with the outside of the box body, and closing the air suction and inlet valve;
c. operating the dropping plug controller to put the ampoule bottle plug;
d. taking out the ampoule bottle from the vacuum inflation box, placing a common ampoule wire-drawing packaging machine, heating the lower edge position of the bottle plug by flame until the ampoule bottle neck is melted, and drawing and sealing the bottle neck at the upper end of a melting point together with the bottle plug by the wire-drawing packaging machine to finish sealing.
Example 3:
the fusion sealing method of the ampoule drawing packaging system specifically comprises the following steps:
a. placing the ampoule bottle body filled with the dried human genome DNA preservation sample in a vacuum inflation box;
b. closing the box door, vacuumizing to 70-90% of vacuum degree, closing the vacuum valve, then filling nitrogen to 0-2% of vacuum degree, repeatedly vacuumizing and filling nitrogen for 7 times, after 7 times of circulation, filling nitrogen until the pressure is balanced with the outside of the box body, and closing the air suction and inlet valve;
c. operating the dropping plug controller to put the ampoule bottle plug;
d. taking out the ampoule bottle from the vacuum inflation box, placing a common ampoule wire-drawing packaging machine, heating the lower edge position of the bottle plug by flame until the ampoule bottle neck is melted, and drawing and sealing the bottle neck at the upper end of a melting point together with the bottle plug by the wire-drawing packaging machine to finish sealing.
The effect is as follows: the embodiment can reduce the oxygen content in the ampoule bottle to be less than 1 percent, and the degradation rate of the human genome DNA storage sample to be one third of that of a sample prepared by a nitrogen-filled wire drawing filling and sealing machine.
The present invention and the embodiments thereof have been described above, but the description is not limited to the embodiments, but only one of the embodiments of the present invention, and the actual embodiments are not limited thereto. In summary, those skilled in the art should appreciate that they can readily use the disclosed conception and specific embodiments as a basis for designing or modifying other structures for carrying out the same purposes of the present invention without departing from the spirit and scope of the invention as defined by the appended claims.
Claims (2)
1. The utility model provides an ampoule wire drawing packaging system, includes vacuum inflation case, ampoule wire drawing packaging machine, its characterized in that: place the ampoule in the vacuum inflation box, the bottle top of ampoule is equipped with the opening, is equipped with the glass stopper in the opening, be equipped with vacuum valve and admission valve on the vacuum inflation box, the vacuum valve is used for connecting the aspiration pump, and the admission valve is used for connecting the inert gas holding vessel, vacuum inflation box internal fixation is equipped with and is used for to placing the stopper controller that falls of glass stopper in the ampoule top opening, and the ampoule after filling in is in melt-seal in the ampoule wire drawing packaging machine.
2. A wire-drawing and sealing method for an ampoule is characterized by comprising the following steps: the method specifically comprises the following steps:
a. placing the ampoule bottle body filled with the biological sample in a vacuum inflation box;
b. sealing the door of the vacuum inflation box, pumping air to vacuum, closing the vacuum valve, then filling inert gas to 0-2% vacuum degree, repeatedly pumping vacuum and filling inert gas, circulating for several times, filling inert gas to balance with the outside of the box body, and closing the air pumping and inlet valves;
c. operating a plug falling controller to place the glass plug into the opening of the ampoule bottle;
d. taking out the ampoule bottle from the vacuum inflation box, placing the ampoule bottle in a common ampoule bottle drawing and packaging machine, heating the lower edge of the bottle plug by flame until the ampoule bottle neck is melted, drawing and sealing the bottle neck at the upper end of a melting point together with the glass plug by the drawing and packaging machine to finish sealing.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201911255553.0A CN110845127A (en) | 2019-12-10 | 2019-12-10 | Ampoule wire drawing packaging system and fusion sealing method |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201911255553.0A CN110845127A (en) | 2019-12-10 | 2019-12-10 | Ampoule wire drawing packaging system and fusion sealing method |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN110845127A true CN110845127A (en) | 2020-02-28 |
Family
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201911255553.0A Pending CN110845127A (en) | 2019-12-10 | 2019-12-10 | Ampoule wire drawing packaging system and fusion sealing method |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN110845127A (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN112722356A (en) * | 2020-12-22 | 2021-04-30 | 宋清云 | Ampoule seals all-in-one by melting |
Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR999411A (en) * | 1952-01-30 | |||
| DE1966127A1 (en) * | 1968-12-27 | 1971-09-23 | Merieux Inst | Ampoule for lyophilic plug shaped products |
| CN205419749U (en) * | 2016-03-14 | 2016-08-03 | 江西傲新生物科技有限公司 | Ampoule wire drawing filling and sealing machine |
| CN110065658A (en) * | 2019-03-27 | 2019-07-30 | 上海璟皓机械科技有限公司 | A kind of plastic ampoule bottle filling and sealing all-in-one machine and filling and sealing method |
| CN209322719U (en) * | 2018-09-13 | 2019-08-30 | 武汉久安药业有限公司 | A kind of wire drawing potting machine fire plate cooling device |
-
2019
- 2019-12-10 CN CN201911255553.0A patent/CN110845127A/en active Pending
Patent Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR999411A (en) * | 1952-01-30 | |||
| DE1966127A1 (en) * | 1968-12-27 | 1971-09-23 | Merieux Inst | Ampoule for lyophilic plug shaped products |
| CN205419749U (en) * | 2016-03-14 | 2016-08-03 | 江西傲新生物科技有限公司 | Ampoule wire drawing filling and sealing machine |
| CN209322719U (en) * | 2018-09-13 | 2019-08-30 | 武汉久安药业有限公司 | A kind of wire drawing potting machine fire plate cooling device |
| CN110065658A (en) * | 2019-03-27 | 2019-07-30 | 上海璟皓机械科技有限公司 | A kind of plastic ampoule bottle filling and sealing all-in-one machine and filling and sealing method |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN112722356A (en) * | 2020-12-22 | 2021-04-30 | 宋清云 | Ampoule seals all-in-one by melting |
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| PB01 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| RJ01 | Rejection of invention patent application after publication |
Application publication date: 20200228 |
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| RJ01 | Rejection of invention patent application after publication |